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Evolution-Based Discovery of Polyketide Acylated Valine from a Cytochalasin-Like Gene Cluster in Simplicillium lamelliciola HDN13430.
Journal of Natural Products 2024 March 7
Utilizing a gene evolution-oriented approach for gene cluster mining, a cryptic cytochalasin-like gene cluster ( sla ) in Antarctic-derived Simplicillium lamelliciola HDN13430 was identified. Compared with the canonical cytochalasin biosynthetic gene clusters (BGCs), the sla gene cluster lacks the key α,β-hydrolase gene. Heterologous expression of the sla gene cluster led to the discovery of a new compound, slamysin ( 1 ), characterized by an N -acylated amino acid structure and demonstrating weak anti- Bacillus cereus activity. These findings underscore the potential of genetic evolution in uncovering novel compounds and indicating specific adaptive evolution within specialized habitats.
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