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American Journal of Respiratory and Critical Care Medicine

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https://www.readbyqxmd.com/read/30641028/protein-phosphatase-2a-reduces-cigarette-smoke-induced-cathepsin-s-and-loss-of-lung-function
#1
Declan F Doherty, Sridesh Nath, Justin Poon, Robert F Foronjy, Michael Ohlmeyer, Abdoulaye J Dabo, Matthias Salathe, Mark Birrell, Maria Belvisi, Nathalie Baumlin, Michael D Kim, Sinéad Weldon, Clifford Taggart, Patrick Geraghty
RATIONALE: Cathepsin S (CTSS) is a cysteine protease that is observed at higher concentrations in bronchoalveolar lavage fluid and plasma of chronic obstructive pulmonary disease (COPD) subjects. OBJECTIVES: The objective of this study was to investigate whether CTSS is involved in the pathogenesis of cigarette smoke-induced COPD and determine whether targeting upstream signaling could prevent the disease. METHODS: CTSS expression was investigated in animal and human tissue and cell models of COPD...
January 14, 2019: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30641027/effect-of-indacaterol-glycopyrronium-on-pulmonary-perfusion-and-ventilation-in-hyperinflated-copd-patients-claim-a-double-blind-randomised-crossover-trial
#2
Jens Vogel-Claussen, Christian-Olaf Schönfeld, Till F Kaireit, Andreas Voskrebenzev, Christoph P Czerner, Julius Renne, Hanns-Christian Tillmann, Korbinian Berschneider, Simone Hiltl, Johann Bauersachs, Tobias Welte, Jens M Hohlfeld
RATIONALE: In the CLAIM study, dual bronchodilation with indacaterol/glycopyrronium (IND/GLY) significantly reduced hyperinflation, which translated into improved cardiac function, measured by left ventricular end-diastolic volume and cardiac output. Pulmonary microvascular blood flow (PMBF) is reduced in COPD; however, the effect of reduced lung hyperinflation on PMBF remains unknown. OBJECTIVES: To determine the effect of lung deflation with IND/GLY on PMBF and regional pulmonary ventilation using magnetic resonance imaging (MRI) in hyperinflated patients with COPD...
January 14, 2019: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30640509/pc20-vs-pd20-why-change-a-scientifically-well-established-and-clinically-relevant-test
#3
Israel Amirav, Michael T Newhouse
No abstract text is available yet for this article.
January 14, 2019: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30640508/reply-to-pc20-vs-pd20-why-change-a-scientifically-well-established-and-clinically-relevant-test
#4
David Kaminsky, Allan Coates, Bruce Culver, Donald Cockcroft, Teal Hallstrand, Jeffrey Haynes, Neil MacIntyre, Jack Wanger
No abstract text is available yet for this article.
January 14, 2019: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30633554/reply-to-deconvoluting-copd-are-b-cells-the-frontrunners
#5
Maha Zohra Ladjemi, Pierre Régis Burgel, Charles Pilette
No abstract text is available yet for this article.
January 11, 2019: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30633537/deconvoluting-copd-are-b-cells-the-frontrunners
#6
Francesca Polverino
No abstract text is available yet for this article.
January 11, 2019: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30630339/body-composition-in-childhood-is-the-window-for-influencing-lung-function-still-open
#7
Sadasivam Suresh, Peter Sly
No abstract text is available yet for this article.
January 11, 2019: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30630337/childhood-body-composition-trajectories-and-adolescent-lung-function-findings-from-the-alspac-study
#8
Gabriela P Peralta, Elaine Fuertes, Raquel Granell, Osama Mahmoud, Célina Roda, Ignasi Serra, Deborah Jarvis, John Henderson, Judith Garcia-Aymerich
RATIONALE: Body composition changes throughout life may explain the inconsistent associations reported between body mass index (BMI) and lung function in children. OBJECTIVES: To assess the associations of body weight and composition trajectories from 7 to 15 years with lung function at 15 years and lung function growth between 8 and 15 years. METHODS: Sex-specific BMI, lean body mass index (LBMI) and fat mass index (FMI) trajectories were developed using Group-Based Trajectory Modeling on data collected at least twice between 7 and 15 years from 6,964 children (49% boys) in the UK Avon Longitudinal Study of Parents and Children birth cohort...
January 11, 2019: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30625278/aetiology-and-risk-factors-for-mortality-in-an-adult-community-acquired-pneumonia-cohort-in-malawi
#9
Stephen J Aston, Antonia Ho, Hannah Jary, Jacqueline Huwa, Tamara Mitchell, Sarah Ibitoye, Simon Greenwood, Elizabeth Joekes, Arthur Daire, Jane Mallewa, Dean Everett, Mulinda Nyirenda, Brian Faragher, Henry C Mwandumba, Robert S Heyderman, Stephen B Gordon
RATIONALE: In the context of rapid antiretroviral therapy (ART) rollout and an increasing burden of non-communicable diseases, there are few contemporary data describing the aetiology and outcome of community-acquired pneumonia (CAP) in sub-Saharan Africa. OBJECTIVES: To describe the current aetiology of CAP in Malawi and identify risk factors for mortality. METHODS: We conducted a prospective observational study of adults hospitalised with CAP to a teaching hospital in Blantyre, Malawi...
January 9, 2019: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30624965/telomere-shortening-behind-the-harm-of-immunosuppressive-therapy-in-idiopathic-pulmonary-fibrosis
#10
Maria Molina-Molina
No abstract text is available yet for this article.
January 9, 2019: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30624956/long-term-outcome-after-prolonged-mechanical-ventilation-a-long-term-acute-care-hospital-study
#11
Amal Jubran, Brydon Jb Grant, Lisa A Duffner, Eileen G Collins, Dorothy M Lanuza, Leslie A Hoffman, Martin J Tobin
RATIONALE: Patients managed at a long-term acute-care hospital (LTACH) for weaning from prolonged mechanical ventilation are at risk for profound muscle weakness and disability. OBJECTIVES: To investigate effects of prolonged ventilation on survival, muscle function and its impact on quality of life at six and twelve months after LTACH discharge. METHODS: Prospective, longitudinal study conducted in 315 patients being weaned from prolonged ventilation at an LTACH...
January 9, 2019: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30608866/electronic-vs-combustible-cigarette-effects-on-inflammasome-component-release-into-human-lung
#12
MuChun Tsai, Min-Ae Song, Christian McAndrew, Theodore M Brasky, Jo L Freudenheim, Ewy Mathé, Joseph McElroy, Sarah A Reisinger, Peter G Shields, Mark D Wewers
No abstract text is available yet for this article.
January 4, 2019: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30608865/is-myocardial-fibrosis-impairing-right-heart-function
#13
Harm Jan Bogaard, Norbert F Voelkel
No abstract text is available yet for this article.
January 4, 2019: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30608863/mechanical-ventilation-during-extracorporal-support-the-relevance-of-tidal-volume
#14
Markus Kredel, Christopher Lotz, Caroline Rolfes, Ralf Muellenbach
No abstract text is available yet for this article.
January 4, 2019: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30608862/reply-to-mechanical-ventilation-during-extracorporal-support-the-relevance-of-tidal-volume
#15
Joaquin Araos, Alejandro Bruhn
No abstract text is available yet for this article.
January 4, 2019: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30605350/comparison-of-physiological-performance-of-four-adaptive-servo-ventilation-devices-in-patients-with-complex-sleep-apnea
#16
James Knitter, Omavi F Bailey, Chithra Poongkunran, Aylene Flores Martinez, Linka Martinez, Ume Kobayashi, Daniel Combs, Richard Lane, Wojciech Zareba, Sairam Parthasarathy
No abstract text is available yet for this article.
January 3, 2019: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30605346/airway-pressure-monitoring-may-improve-small-airway-flow-hemodynamics-and-tissue-oxygenation
#17
Athanasios Chalkias, Theodoros Xanthos
No abstract text is available yet for this article.
January 3, 2019: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30605345/reply-to-airway-pressure-monitoring-may-improve-small-airway-flow-hemodynamics-and-tissue-oxygenation
#18
Domenico L Grieco, Laurent Brochard, Jean-Christophe M Richard
No abstract text is available yet for this article.
January 3, 2019: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30592902/copd-biomarkers-and-their-interpretation
#19
Robert A Stockley, David M G Halpin, Bartolome R Celli, Dave Singh
The pathology and impact of COPD results from an abnormal inflammatory process resulting in tissue damage with ineffective repair in response to toxic inhalants (especially cigarette smoke). Identification of mechanisms provides the opportunity to develop new therapies and a personalised approach to management. The collection of multiple genetic and detailed biochemical data from small and large patient cohorts has led to an explosion of studies investigating biomarkers, to achieve these aims. Despite widespread enthusiasm and many statistically significant associations, the interpretation of COPD biomarker results requires thought and leaves many questions unanswered...
December 28, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30592637/smooth-muscle-cells-a-novel-site-of-p-selectin-expression-with-pathophysiological-and-therapeutic-relevance-in-pulmonary-hypertension
#20
Prithu Sundd, Wolfgang M Kuebler
No abstract text is available yet for this article.
December 28, 2018: American Journal of Respiratory and Critical Care Medicine
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