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American Journal of Respiratory and Critical Care Medicine

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https://www.readbyqxmd.com/read/28737971/fluticasone-furoate-vilanterol-and-lung-function-decline-in-patients-with-moderate-copd-and-heightened-cardiovascular-risk
#1
Peter M A Calverley, Julie A Anderson, Robert D Brook, Courtney Crim, Natacha Gallot, Sally Kilbride, Fernando Martinez, Julie Yates, David E Newby, Jørgen Vestbo, Robert Wise, Bartolome R Celli
RATIONALE: Many patients with chronic obstructive pulmonary disease (COPD) have an accelerated loss of lung function. It is unclear whether drug treatment can modify this in moderately severe disease. OBJECTIVES: In a pre-specified analysis of the key secondary outcome in the Study to Understand Mortality and MorbidITy (SUMMIT), we investigated whether the inhaled corticosteroid fluticasone furoate 100 μg (FF), the long-acting beta-agonist vilanterol 25 µg (VI) or the combination (FF/VI) modified the rate of decline in FEV1 compared with placebo...
July 24, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28737960/optimization-and-interpretation-of-serial-quantiferon-testing-to-measure-acquisition-of-m-tuberculosis-infection
#2
Elisa Nemes, Virginie Rozot, Hennie Geldenhuys, Nicole Bilek, Simbarashe Mabwe, Deborah Abrahams, Lebohang Makhethe, Mzwandile Erasmus, Alana Keyser, Asma Toefy, Yolundi Cloete, Frances Ratangee, Thomas Blauenfeldt, Morten Ruhwald, Gerhard Walzl, Bronwyn Smith, Andre G Loxton, Willem A Hanekom, Jason R Andrews, Maria D Lempicki, Ruth Ellis, Ann M Ginsberg, Mark Hatherill, Thomas J Scriba
RATIONALE: Conversion from a negative to positive QuantiFERON-TB test is indicative of Mycobacterium tuberculosis (M.tb) infection, which predisposes to tuberculosis disease. Interpretation of serial tests is confounded by immunological and technical variability. OBJECTIVES: To improve consistency of serial QuantiFERON-TB testing algorithms and provide a data-driven definition of conversion. METHODS: Sources of QuantiFERON-TB variability were assessed and optimal procedures identified...
July 24, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28731387/a-comparative-analysis-of-pulmonary-and-critical-care-medicine-guideline-development-methodologies
#3
Noah C Schoenberg, Alan F Barker, John Bernardo, Robin R Deterding, Jerrold J Ellner, Dean R Hess, Neil R MacIntyre, Fernando J Martinez, Kevin C Wilson
BACKGROUND: The Institute of Medicine (IOM) standards for guideline development have had unintended negative consequences. A more efficient approach is desirable. OBJECTIVE: To determine whether a modified Delphi process early during guideline development discriminates recommendations that should be informed by a systematic review from those that can be based upon expert consensus. METHODS: The same questions addressed by IOM-compliant pulmonary or critical care guidelines were addressed by expert panels using a modified Delphi process, the Convergence of Opinion on Recommendations and Evidence (CORE) process...
July 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28731363/fifty-years-of-research-in-ards-ards-how-it-all-began
#4
Bernard E Levine
No abstract text is available yet for this article.
July 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28731360/communications-between-pulmonary-airways-and-blood-vessels-a-new-mechanism
#5
Stephen H Loring
No abstract text is available yet for this article.
July 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28731358/toward-early-identification-of-clinically-relevant-interstitial-lung-disease
#6
Margaret L Salisbury, David A Lynch
No abstract text is available yet for this article.
July 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28727491/impact-of-point-of-care-xpert-mtb-rif-on-tuberculosis-treatment-initiation-a-cluster-randomised-trial
#7
Richard J Lessells, Graham S Cooke, Nuala McGrath, Mark P Nicol, Marie-Louise Newell, Peter Godfrey-Faussett
RATIONALE: Point-of-care (POC) diagnostics have potential to reduce pre-treatment loss to follow-up and delays to initiation of appropriate TB treatment. OBJECTIVE: To evaluate the effect of a POC diagnostic strategy on initiation of appropriate TB treatment. METHODS: A cluster randomised trial of adults with cough who were HIV positive and/or at high risk of drug-resistant TB. Two-week time blocks were randomised to two strategies (i) Xpert performed at district hospital laboratory (ii) POC Xpert performed at primary health care clinic...
July 20, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28726501/cigarette-smoke-is-an-endothelial-cell-toxin
#8
Norbert F Voelkel
No abstract text is available yet for this article.
July 20, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28726487/sensitive-windows-for-in-utero-exposures-and-asthma-development-layers-of-complexity
#9
Cindy T McEvoy, Byung S Park, Eliot R Spindel
No abstract text is available yet for this article.
July 20, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28726486/reply-to-cigarette-smoke-is-an-endothelial-cell-toxin
#10
Francesca Polverino, Bartolome R Celli, Caroline A Owen
No abstract text is available yet for this article.
July 20, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28723315/pneumonia-and-the-risk-of-cardiovascular-death-time-to-change-our-strategy
#11
Tobias Welte, Mathias Pletz
No abstract text is available yet for this article.
July 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28723313/time-for-an-international-consensus-on-hypersensitivity-pneumonitis-a-call-to-arms
#12
Philip L Molyneaux, Toby M Maher
No abstract text is available yet for this article.
July 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28723257/reply-to-capturetm%C3%A2-a-screening-tool-for-copd-or-obstructive-airways-disease
#13
Fernando J Martinez, MeiLan Han, Nancy Leidy, Barry Make, David M Mannino, Stephen I Rennard, Byron M Thomashow, Barbara P Yawn
No abstract text is available yet for this article.
July 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28723247/-capture-tm-%C3%A2-a-screening-tool-for-copd-or-obstructive-airways-disease
#14
Jyoti Deepak Londhe, Komalkirti Apte, Monica Sumit Barne, Sundeep Salvi
No abstract text is available yet for this article.
July 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28722466/assessing-the-generalizability-of-the-national-lung-screening-trial-comparison-of-stage-1-patients
#15
Nichole T Tanner, Lin Dai, Brett C Bade, Mulugeta Gebregziabher, Gerard A Silvestri
RATIONALE: The findings of the National Lung Screening Trial (NLST) is the basis for screening high risk individuals based on age and smoking history. While screening is covered for eligible Medicare beneficiaries, the generalizability of the NLST in the elderly population has been questioned. OBJECTIVE: Compare outcomes of patients diagnosed with stage 1 non-small cell lung cancer(NSCLC) in the NLST to a nationally representative cohort of elderly patients Methods: Analysis of SEER-Medicare and NLST datasets for stage 1 patients ages 65-74 Measurements and Main Results: Lung cancer-specific mortality, all-cause mortality, and 30-60-90 day treatment mortality were measured...
July 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28719759/airway-closure-could-be-confirmed-by-electrical-impedance-tomography
#16
Xiu-Mei Sun, Guang-Qiang Chen, Yi-Min Zhou, Yan-Lin Yang, Jian-Xin Zhou
No abstract text is available yet for this article.
July 18, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28719757/the-plasma-concentration-of-muc5b-is-associated-with-clinical-outcomes-in-paraquat-poisoned-patients
#17
Andrew A Monte, Hao Sun, Anna Malin Rapp-Olsson, Fahim Mohamed, Indika Gawarammana, Nicholas A Buckley, Christopher M Evans, Ivana V Yang, David A Schwartz
No abstract text is available yet for this article.
July 18, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28715258/reply-from-the-authors-of-eligibility-for-the-shorter-mdr-tb-regimen-ambiguities-in-the-who-recommendations
#18
Francis Varaine, Lorenzo Guglielmetti, Carole D Mitnick
No abstract text is available yet for this article.
July 17, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28715229/reply-from-the-authors-of-limited-benefit-of-the-new-shorter-mdr-tb-regimen-in-europe
#19
Frank van Leth, Gunar Guenther, Harald Hoffmann, Christoph Lange
No abstract text is available yet for this article.
July 17, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28665681/benefit-of-the-shorter-mdr-tb-treatment-regimen-in-california-and-modified-eligibility-criteria
#20
Pennan M Barry, Phil Lowenthal, Lisa True, Leslie Henry, Gayle Schack, Kristen Wendorf, Jennifer Flood, Neha Shah
No abstract text is available yet for this article.
July 17, 2017: American Journal of Respiratory and Critical Care Medicine
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