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American Journal of Respiratory and Critical Care Medicine

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https://www.readbyqxmd.com/read/28644040/hypoxic-pulmonary-vasoconstriction-does-not-explain-all-regional-perfusion-redistribution-in-asthma
#1
Vanessa J Kelly, Kathryn A Hibbert, Puja Kohli, Mamary Kone, Elliot E Greenblatt, Jose G Venegas, Tilo Winkler, R Scott Harris
RATIONALE: Regional hypoventilation in bronchoconstricted asthmatics is spatially associated with reduced perfusion, which is proposed to result from Hypoxic Pulmonary Vasoconstriction (HPV). Our study aimed to determine the role of HPV in the regional perfusion redistribution in bronchoconstricted asthmatics. METHODS: Eight asthmatics completed PET-CT lung imaging at baseline and after bronchoconstriction, breathing either Room Air or 80% Oxygen (80%O2, separate days)...
June 23, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28644036/examining-the-effect-of-residual-amikacin-on-sputum-culture-for-nontuberculous-mycobacteria
#2
Gina Eagle, Karen Brown, R Andres Floto
No abstract text is available yet for this article.
June 23, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28640654/reply-to-epithelial-mesenchymal-transition-emt-a-necessary-new-therapeutic-target-in-copd
#3
Jing Yang, Renat Shaykhiev
No abstract text is available yet for this article.
June 22, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28640653/epithelial-mesenchymal-transition-emt-a-necessary-new-therapeutic-target-in-copd
#4
Sukhwinder Singh Sohal, Mathew Suji Eapen, Chris Ward, Eugene Haydn Walters
No abstract text is available yet for this article.
June 22, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28640650/exposure-interaction-a-life-long-phenomenon-with-relevance-to-chronic-obstructive-pulmonary-disease
#5
Jørgen Vestbo, Peter Lange
No abstract text is available yet for this article.
June 22, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28640649/asthma-attacks-in-children-does-blocking-ige-reduce-rhinoviral-infections
#6
Sejal Saglani, Andrew Bush
No abstract text is available yet for this article.
June 22, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28640648/extracellular-vesicle-transfer-from-mesenchymal-stromal-cells-modulates-macrophage-function-in-acute-lung-injury-basic-science-and-clinical-implications
#7
Michael A Matthay
No abstract text is available yet for this article.
June 22, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28640643/osa-and-diabetic-mellitus-seeing-beyond-glycemic-control
#8
Mary S M Ip, David Wong
No abstract text is available yet for this article.
June 22, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28636425/ats-nhlbi-asthma-copd-overlap-aco-workshop-report
#9
Prescott G Woodruff, Maarten van den Berge, Richard C Boucher, Christopher Brightling, Esteban G Burchard, Stephanie A Christenson, MeiLan K Han, Michael J Holtzman, Monica Kraft, David A Lynch, Fernando D Martinez, Helen K Reddel, Don D Sin, George R Washko, Sally E Wenzel, Antonello Punturieri, Michelle M Freemer, Robert A Wise
Asthma and COPD are highly prevalent chronic obstructive lung diseases with an associated high burden of disease. Asthma, which is often allergic in origin, frequently begins in infancy or childhood with variable airflow obstruction and intermittent wheezing, cough, and dyspnea. Patients with COPD, in contrast, are usually current or former smokers who present after the age of 40 years with symptoms (often persistent), including dyspnea and a productive cough. Based on age and smoking history, it is often easy to distinguish between asthma and COPD...
June 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28636407/pulmonary-endpoints-in-duchenne-muscular-dystrophy-a-workshop-summary
#10
Jonathan Finder, Oscar Henry Mayer, Daniel Sheehan, Hemant Sawnani, R Ted Abresch, Joshua Benditt, David J Birnkrant, Tina Duong, Erik Henricson, Kathi Kinnett, Craig M McDonald, Anne M Connolly
Development of novel therapeutics for treatment of Duchenne muscular dystrophy (DMD) has led to clinical trials that include pulmonary endpoints that allow assessment of respiratory muscle status, especially in non-ambulatory subjects. Parent Project Muscular Dystrophy (PPMD) convened a workshop in Bethesda, MD from April 14-15, 2016 to summarize published respiratory data in DMD and give guidance to clinical researchers assessing the effect of interventions on pulmonary outcomes in DMD.
June 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28636405/conventional-polysomnography-is-not-necessary-for-the-management-of-most-patients-with-suspected-obstructive-sleep-apnea
#11
Jaime Corral, Maria-Ángeles Sánchez-Quiroga, Carmen Carmona-Bernal, Ángeles Sánchez-Armengol, Alicia Sánchez-de-la-Torre, Joaquín Durán-Cantolla, Carlos J Egea, Neus Salord, Carmen Monasterio, Joaquín Terán, M Luz Alonso-Alvarez, Jesús Muñoz-Méndez, Eva M Arias, Marta Cabello, Josep M Montserrat, Mónica De la Peña, José C Serrano, Ferran Barbe, Juan F Masa
RATIONALE: Home respiratory polygraphy may be a simpler alternative to in-laboratory polysomnography for the management of more symptomatic obstructive sleep apnea patients, but its effectiveness has not been evaluated across a broad clinical spectrum. OBJECTIVE: To compare the long-term effectiveness (6 months) of home respiratory polygraphy and polysomnography management protocols in patients with intermediate to high sleep apnea suspicion (most patients requiring a sleep study)...
June 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28636403/applying-precision-medicine-to-trial-design-using-physiology-extracorporeal-co2-removal-for-ards
#12
Ewan C Goligher, Marcelo B P Amato, Arthur S Slutsky
In clinical trials of therapies for ARDS, the average treatment effect in the study population may be attenuated because individual patient responses vary widely. This inflates sample size requirements and increases the cost and difficulty of conducting successful clinical trials. One solution is to enrich the study population with patients most likely to benefit based on predicted patient response to treatment (predictive enrichment). In this perspective, we apply the precision medicine paradigm to the emerging use of extracorporeal CO2 removal (ECCO2R) for ultra-protective ventilation in ARDS...
June 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28628389/an-ounce-of-prevention%C3%A2-will-this-be-the-future-for-ipf
#13
Joyce S Lee
No abstract text is available yet for this article.
June 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28628377/environmental-effects-of-intensive-livestock-farming
#14
Torben Sigsgaard, John Balmes
No abstract text is available yet for this article.
June 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28628375/integrating-microbiome-and-metabolome-data-to-understand-infectious-airway-disease
#15
Robert A Quinn
n/a.
June 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28628339/picornavectors
#16
James E Gern
No abstract text is available yet for this article.
June 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28614669/severe-pneumococcal-pneumonia-causes-acute-cardiac-toxicity-and-subsequent-cardiac-remodeling
#17
Luis F Reyes, Marcos I Restrepo, Cecilia A Hinojosa, Nilam J Soni, Antonio Anzueto, Bettina L Babu, Norberto Gonzalez-Juarbe, Alejandro H Rodriguez, Alejandro Jimenez, James D Chalmers, Stefano Aliberti, Oriol Sibila, Vicki T Winter, Jacqueline J Coalson, Luis D Giavedoni, Charles S Dela Cruz, Grant W Waterer, Martin Witzenrath, Norbert Suttorp, Peter H Dube, Carlos J Orihuela
RATIONALE: Up to one-third of the patients hospitalized with pneumococcal pneumonia experience major adverse cardiac events (MACE) during or after pneumonia. In mice, Streptococcus pneumoniae can invade the myocardium, induce cardiomyocyte death, and disrupt cardiac function following bacteremia, but it is unknown whether the same occurs in humans with severe pneumonia. OBJECTIVE: We sought to determine whether S. pneumoniae can 1) translocate the heart, 2) induce cardiomyocyte death, 3) cause MACE, and 4) induce cardiac scar formation post-antibiotic treatment during severe pneumonia using a non-human primates (NHP) model...
June 14, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28614668/cryptic-micro-heteroresistance-explains-m-tuberculosis-phenotypic-resistance
#18
John Z Metcalfe, Elizabeth Streicher, Grant Theron, Rebecca E Colman, Christopher Allender, Darrin Lemmer, Rob Warren, David M Engelthaler
BACKGROUND: Minority resistant M. tuberculosis subpopulations can be associated with phenotypic resistance, but are poorly detected by Sanger sequencing or commercial molecular diagnostic assays. The role of targeted next generation sequencing (NGS) in resolving these minor variant subpopulations is unclear. METHODS: We utilized Single Molecule-Overlapping Reads (SMOR), a targeted NGS approach that dramatically reduces sequencing error, to analyze primary cultured isolates phenotypically resistant to rifampin, fluoroquinolones, or aminoglycosides, but for which Sanger sequencing found no resistance-associated variants (RAVs) within respective resistance determining regions (RDRs) (Study Group)...
June 14, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28613924/spirometry-reference-equations-from-the-hispanic-community-health-study-study-of-latinos-hchs-sol
#19
Lisa LaVange, Sonia M Davis, John Hankinson, Paul Enright, Rebbecca Wilson, R Graham Barr, Thomas K Aldrich, Ravi Kalhan, Hector Lemus, Ai Ni, Lewis J Smith, Gregory A Talavera
RATIONALE: Accurate reference values for spirometry are important, as the results are used for diagnosing common chronic lung diseases such as asthma and chronic obstructive pulmonary disease, estimating physiological impairment, and predicting all-cause mortality. Reference equations have been established for Mexican Americans but not for other Hispanic/Latino backgrounds. OBJECTIVES: To develop spirometry reference equations for adult Hispanic/Latino background groups in the United States...
June 14, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28613921/high-attenuation-areas-on-chest-ct-and-clinical-respiratory-outcomes-in-community-dwelling-adults
#20
Anna J Podolanczuk, Elizabeth C Oelsner, R Graham Barr, Elana J Bernstein, Eric A Hoffman, Imaani J Easthausen, Karen Hinckley Stukovsky, Arindam RoyChoudhury, Erin D Michos, Ganesh Raghu, Steven M Kawut, David J Lederer
RATIONALE: Areas of increased lung attenuation on computed tomography are associated with all-cause mortality in the general population. It is uncertain whether this association is attributable to interstitial lung disease (ILD). OBJECTIVES: To determine whether high attenuation areas are associated with the risk of ILD hospitalization and mortality in the general population. METHODS: We performed a cohort study of 6,808 adults aged 45-84 sampled from six communities in the United States...
June 14, 2017: American Journal of Respiratory and Critical Care Medicine
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