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American Journal of Respiratory and Critical Care Medicine

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https://www.readbyqxmd.com/read/29161116/corticosteroid-therapy-for-critically-ill-patients-with-the-middle-east-respiratory-syndrome
#1
Yaseen M Arabi, Yasser Mandourah, Fahad Al-Hameed, Anees A Sindi, Ghaleb A Al Mekhlafi, Mohamed A Hussein, Jesna Jose, Ruxandra Pinto, Awad Al-Omari, Ayman Kharaba, Abdullah Almotairi, Kasim Al Khatib, Basem Alraddadi, Sarah Shalhoub, Ahmed Abdulmomen, Ismael Qushmaq, Ahmed Mady, Othman Solaiman, Abdulsalam M Al-Aithan, Rajaa Al-Raddadi, Ahmed Ragab, Hanan H Balkhy, Abdulrahman Al Harthy, Ahmad M Deeb, Hanan Al Mutairi, Abdulaziz Al-Dawood, Laura Merson, Frederick G Hayden, Robert A Fowler
RATIONALE: Corticosteroid therapy is commonly used among critically ill patients with the Middle East Respiratory Syndrome (MERS), but its impact on outcomes is uncertain. Analyses of observational studies often do not account for patients' clinical condition at the time of corticosteroid therapy initiation. OBJECTIVES: To investigate the association of corticosteroid therapy on mortality and on MERS coronavirus RNA clearance in critically ill patients with MERS...
November 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29161093/b-cells-producing-type-i-interferon-modulate-macrophage-polarization-in-tuberculosis
#2
Alan Bénard, Imme Sakwa, Pablo Schierloh, André Colom, Ingrid Mercier, Ludovic Tailleux, Luc Jouneau, Pierre Boudinot, Talal Al-Saati, Roland Lang, Jan Rehwinkel, Andre G Loxton, Stefan He Kaufmann, Véronique Anton-Leberre, Anne O'Garra, Maria Del Carmen Sasiain, Brigitte Gicquel, Simon Fillatreau, Olivier Neyrolles, Denis Hudrisier
RATIONALE: In addition to their well-known function as antibody-producing cells, B lymphocytes can markedly influence the course of infectious or non-infectious diseases via antibody-independent mechanisms. In tuberculosis, B cells accumulate in lungs, yet their functional contribution to the host response remains poorly understood. OBJECTIVES: To document the role of B cells in tuberculosis in an unbiased manner. METHODS: We generated the transcriptome of B cells isolated from Mycobacterium tuberculosis (Mtb)-infected mice, and validated the identified key pathways using in vitro and in vivo assays...
November 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29161057/e-cigarettes-mucus-measurements-make-marks
#3
Christopher M Evans, Burton F Dickey, David A Schwartz
No abstract text is available yet for this article.
November 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29160730/reply-to-exosome-treatment-of-bronchopulmonary-dysplasia-how-pure-should-your-exosome-preparation-be
#4
S Alex Mitsialis, Gareth R Willis, Angeles Fernandez-Gonzalez, Stella Kourembanas
No abstract text is available yet for this article.
November 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29160726/gene-environment-interactions-associated-with-the-severity-of-acute-asthma-exacerbation-in-children
#5
David B Kantor, Wanda Phipatanakul, Joel N Hirschhorn
No abstract text is available yet for this article.
November 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29160724/exosome-treatment-of-bronchopulmonary-dysplasia-how-pure-should-your-exosome-preparation-be
#6
Maurizio Muraca, Patrizia Zaramella, Andrea Porzionato, Eugenio Baraldi
No abstract text is available yet for this article.
November 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29155600/recommended-reading-from-boston-university-school-of-medicine-pulmonary-and-critical-care-medicine-fellows
#7
Eric D Abston, Stephanie M Hon, Andrew Berical, Christine L Reardon
No abstract text is available yet for this article.
November 20, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29155599/recombinant-fragment-of-human-surfactant-protein-d-a-hierarchical-regulator-of-pulmonary-hypersensitivity
#8
Taruna Madan
No abstract text is available yet for this article.
November 20, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29144885/systemic-and-airway-inflammation-after-exposure-to-fumes-from-military-small-arms
#9
Liv I B Sikkeland, Anne K Borander, Øyvind A Voie, Hans C D Aass, Reidun Øvstebø, Pål Aukrust, Kjetil Longva, Neil E Alexis, Johny Kongerud, Thor Ueland
No abstract text is available yet for this article.
November 16, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29144158/glycosylation-repurposes-alpha-1-antitrypsin-for-resolution-of-community-acquired-pneumonia
#10
Cormac McCarthy, Danielle M Dunlea, Radka Saldova, Michael Henry, Paula Meleady, Oliver J McElvaney, Brian Marsh, Pauline M Rudd, Emer P Reeves, Noel G McElvaney
No abstract text is available yet for this article.
November 16, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29141154/obstructive-sleep-apnea-and-cardiovascular-disease-rem-sleep-matters
#11
Babak Mokhlesi, Andrew W Varga
No abstract text is available yet for this article.
November 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29140725/reply-to-the-significance-of-eosinophilic-inflammation-in-copd
#12
Nicolas Roche, Kenneth R Chapman, Claus F Vogelmeier, Felix J F Herth, Chau Thach, Robert Fogel, Petter Olsson, Francesco Patalano, Donald Banerji, Jadwiga A Wedzicha
No abstract text is available yet for this article.
November 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29140724/the-significance-of-eosinophilic-inflammation-in-copd
#13
Christopher B Cooper, Guy Brusselle, Steven J Pascoe, Ian D Pavord
No abstract text is available yet for this article.
November 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29131651/increased-echocardiographic-pulmonary-pressure-in-hiv-infected-and-uninfected-individuals-in-the-veterans-aging-cohort-study
#14
Evan L Brittain, Meredith S Duncan, Joyce Chang, Olga V Patterson, Scott L DuVall, Cynthia A Brandt, Kaku A So-Armah, Matthew Goetz, Kathleen Akgun, Kristina Crothers, Courtney Zola, Joon Kim, Cynthia Gibert, Margaret Pisani, Alison Morris, Priscilla Hsue, Hilary A Tindle, Amy Justice, Matthew Freiberg
BACKGROUND: The epidemiology and prognostic impact of increased pulmonary pressure among HIV-infected individuals in the antiretroviral therapy era is not well described. METHODS: This study evaluated 8,296 veterans referred for echocardiography with reported pulmonary artery systolic pressure (PASP) estimates from the Veterans Aging Cohort study, an observational cohort of HIV-infected and uninfected veterans matched by age, sex, race/ethnicity, and clinical site...
November 13, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29125327/obstructive-sleep-apnea-severity-affects-amyloid-burden-in-cognitively-normal-elderly-a-longitudinal-study
#15
Ram A Sharma, Andrew W Varga, Omonigho M Bubu, Elizabeth Pirraglia, Korey Kam, Ankit Parekh, Margaret Wohlleber, Margo D Miller, Andreia Andrade, Clifton Lewis, Samuel Tweardy, Maja Buj, Po L Yau, Reem Sadda, Lisa Mosconi, Yi Li, Tracy Butler, Lidia Glodzik, Els Fieremans, James S Babb, Kaj Blennow, Henrik Zetterberg, Shou E Lu, Sandra G Badia, Sergio Romero, Ivana Rosenzweig, Nadia Gosselin, Girardin Jean-Louis, David M Rapoport, Mony J de Leon, Indu Ayappa, Ricardo S Osorio
RATIONALE: Recent evidence suggests that Obstructive Sleep Apnea (OSA) may be a risk factor for developing Mild Cognitive Impairment and Alzheimer's disease. However, how sleep apnea affects longitudinal risk for Alzheimer's disease is less well understood. OBJECTIVE: To test the hypothesis that there is an association between severity of OSA and longitudinal increase in amyloid burden in cognitively normal elderly. METHODS: Data was derived from a 2-year prospective longitudinal study that sampled community-dwelling healthy cognitively normal elderly...
November 10, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29125306/unilateral-acute-respiratory-distress-syndrome-with-contralateral-pulmonary-artery-agenesis
#16
Chetan Pasrija, Zachary N Kon, Jean Jeudy, Pablo G Sanchez
No abstract text is available yet for this article.
November 10, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29121479/cdhr3-genetics-and-rhinovirus-c-respiratory-illnesses
#17
Klaus Bønnelykke, Amaziah T Coleman, Michael D Evans, Jonathan Thorsen, Johannes Waage, Nadja H Vissing, Christian J Carlsson, Jakob Stokholm, Bo L Chawes, Leon E Jessen, Thea K Fischer, Yury A Bochkov, Carole Ober, Robert F Lemanske, Daniel J Jackson, James E Gern, Hans Bisgaard
Background Experimental evidence suggests that CDHR3 is a receptor for rhinovirus-C (RV-C), and a missense variant in this gene (rs6967330) is associated with childhood asthma with severe exacerbations. Objective To determine whether rs6967330 influences RV-C infections and illnesses in early childhood. Methods We studied associations between rs6967330 and respiratory infections and illnesses in the COPSAC2010 and COAST birth cohorts, where respiratory infections were monitored prospectively for the first 3 years of life...
November 9, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29120664/sequestering-damps-in-critical-illness-a-novel-homeostatic-role-for-the-erythrocyte
#18
Joseph A Hippensteel, Eric P Schmidt
No abstract text is available yet for this article.
November 9, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29120663/interferon-stimulated-genes-and-non-t2-inflammation-new-pathway-or-red-herring
#19
Sunita Sharma, Fernando Holguin
No abstract text is available yet for this article.
November 9, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29112823/obstructive-sleep-apnea-during-rapid-eye-movement-sleep-and-cardiovascular-disease
#20
R Nisha Aurora, Ciprian Crainiceanu, Daniel J Gottlieb, Ji Soo Kim, Naresh M Punjabi
BACKGROUND: Obstructive sleep apnea (OSA) during rapid eye movement (REM) sleep is a common disorder. Data on whether OSA that occurs predominantly during REM sleep is associated with health outcomes are limited. The present study examined the association between OSA during REM sleep and a composite cardiovascular endpoint in a community sample with and without prevalent cardiovascular disease. METHODOLOGY: Full montage home polysomnography was conducted as part of the Sleep Heart Health Study...
November 7, 2017: American Journal of Respiratory and Critical Care Medicine
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