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American Journal of Respiratory and Critical Care Medicine

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https://www.readbyqxmd.com/read/29782808/mortality-in-cpap-treated-patients-at-the-population-level
#1
Jordi de Batlle, Sandra Bertran, Cecilia Turino, Joan Escarrabill, Manuel Sánchez-de-la-Torre, Holger Woehrle, Ferran Barbé
No abstract text is available yet for this article.
May 21, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29782807/bronchial-impaction-of-arterial-coil
#2
Seung Yong Park, Myoung Ja Chung, Kum Ju Chae, Heung Bum Lee, Seoung Ju Park
No abstract text is available yet for this article.
May 21, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29782179/early-intravascular-events-are-associated-with-development-of-ards
#3
Raja-Elie E Abdulnour, Tina Gunderson, Ioanna Barkas, Jack Y Timmons, Cindy Barnig, Michelle Gong, Daryl J Kor, Ognjen Gajic, Daniel Talmor, Rickey E Carter, Bruce D Levy
RATIONALE: The acute respiratory distress syndrome (ARDS) is a devastating illness with limited therapeutic options. A better understanding of early biochemical and immunological events in ARDS could inform the development of new preventive and treatment strategies. OBJECTIVE: To determine select peripheral blood lipid mediator and leukocyte responses in patients at-risk for ARDS. METHODS: Patients at risk for ARDS were randomized as part of a multicenter, double-blind clinical trial of aspirin versus placebo (LIPS-A; NCT01504867)...
May 21, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29782178/early-returns-in-vascular-inflammation-in-ards
#4
Elizabeth A Middleton, Guy A Zimmerman
No abstract text is available yet for this article.
May 21, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29779416/long-term-triple-therapy-de-escalation-to-indacaterol-glycopyrronium-in-copd-patients-sunset-a-randomized-double-blind-triple-dummy-clinical-trial
#5
Kenneth R Chapman, John R Hurst, Stefan-Marian Frent, Michael Larbig, Robert Fogel, Tadhg Guerin, Donald Banerji, Francesco Patalano, Pankaj Goyal, Pascal Pfister, Konstantinos Kostikas, Jadwiga A Wedzicha
RATIONALE: There are no studies on ICS withdrawal in patients on long-term triple therapy in the absence of frequent exacerbations. OBJECTIVE: To evaluate the efficacy and safety of the direct de-escalation from long-term triple therapy to indacaterol/glycopyrronium in non-frequently exacerbating COPD patients. METHODS: This 26-week, randomized, double-blind, triple-dummy study assessed the direct change from long-term triple therapy to indacaterol/glycopyrronium (110/50μg once daily) or continuation of triple therapy (tiotropium 18μg once daily plus combination of salmeterol/fluticasone propionate [50/500μg] twice daily) in non-frequently exacerbating patients with moderate-to-severe COPD...
May 20, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29775087/does-armodafinil-improve-driving-task-performance-and-weight-loss-in-sleep-apnea-a-randomized-trial
#6
Julia Louise Chapman, Elizabeth Anne Cayanan, Camilla Miranda Hoyos, Yasmina Serinel, Maria Comas, Brendon John Yee, Keith Keat Huat Wong, Ronald Robert Grunstein, Nathaniel Stuart Marshall
RATIONALE Obstructive sleep apnea (OSA) patients unable to tolerate standard treatments have few alternatives. They may benefit from weight loss, but the major symptom of daytime performance impairment may remain during weight loss programs. OBJECTIVES We hypothesized that wakefulness-promoter armodafinil would improve driving task performance over placebo in patients undergoing weight loss. METHODS Placebo-controlled, double-blind, randomized trial of Armodafinil vs Placebo daily for 6 months in patients who were also randomized to one of two diets for six months with follow-up at one year in overweight, adult, OSA patients who had rejected standard treatment and suffered daytime sleepiness...
May 18, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29768034/staphylococcus-aureus-induces-mucosal-type-2-immune-response-via-epithelial-cell-derived-cytokines
#7
Feng Lan, Nan Zhang, Gabriele Holtappels, Natalie De Ruyck, Olga Krysko, Koen Van Crombruggen, Harald Braun, Sebastian L Johnston, Nikos G Papadopoulos, Luo Zhang, Claus Bachert
RATIONALE: Chronic rhinosinusitis with nasal polyps is characterized by a T helper cell 2-skewed upper airway inflammation. Mucosal Staphylococcus aureus colonization is found in the majority of nasal polyps patients. Staphylococcus aureus is known to induce type 2 cytokine release via enterotoxins. OBJECTIVES: We investigated the impact of non-enterotoxin producing Staphylococcus aureus on type 2 cytokine release. METHODS: Thymic stromal lymphopoietin, interleukin-33 and type 2 cytokines were assessed in a human mucosal tissue model upon Staphylococcus aureus infection...
May 16, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29768025/the-post-injury-inflammatory-state-and-the-bone-marrow-response-to-anemia
#8
Tyler J Loftus, Juan C Mira, Elizabeth S Miller, Kolenkode B Kannan, Jessica M Plazas, Daniel Delitto, Julie A Stortz, Jennifer E Hagen, Hari K Parvataneni, Kalia K Sadasivan, Scott C Brakenridge, Frederick A Moore, Lyle L Moldawer, Philip A Efron, Alicia M Mohr
RATIONALE: The pathophysiology of persistent injury-associated anemia is incompletely understood, and human data are sparse. OBJECTIVE: To translate pre-clinical findings by characterizing injury-associated anemia among critically ill trauma patients. This study compared elective hip repair patients with an acute stress response to severely injured trauma patients with a prolonged stress response and evaluated the bone marrow response to anemia. METHODS: A translational prospective observational cohort study comparing severely injured, blunt trauma patients who had operative fixation of a hip or femur fracture (n=17) with elective hip repair patients (n=22) and healthy donors (n=8)...
May 16, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29768023/nk-cell-looks-like-a-sniper-but-is-part-of-the-team
#9
Marina Saetta, Graziella Turato, Manuel G Cosio
No abstract text is available yet for this article.
May 16, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29763573/a-cross-sectional-assessment-of-rhinitis-symptoms-and-nasal-patency-in-relation-to-welding-exposure
#10
Mahsa Taghiakbari, Roberto Castano, Alfi Afadiyanti Parfi, Meshack Achore, Mariam El-Zein, Mounia Senhaji Rhazi, Denyse Gautrin, Eva Suarthana
No abstract text is available yet for this article.
May 15, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29763572/determinants-of-response-to-roflumilast-in-severe-copd-pooled-analysis-of-two-randomized-trials
#11
Fernando J Martinez, Klaus F Rabe, Peter M A Calverley, Leonardo M Fabbri, Sanjay Sethi, Emilio Pizzichini, Andrew McIvor, Antonio Anzueto, Vijay K T Alagappan, Shahid Siddiqui, Colin Reisner, Sofia Zetterstrand, Jonas Román, Debasree Purkayastha, Nitin Bagul, Stephen I Rennard
RATIONALE: Roflumilast reduces exacerbations in patients with severe chronic obstructive pulmonary disease associated with chronic bronchitis and a history of exacerbations. Further characterization of patients most likely to benefit is warranted. OBJECTIVES: Define characteristics that most robustly identify patients who derive greatest exacerbation risk reduction with roflumilast. METHODS: Predefined, pooled analyses of REACT (NCT01329029) and RE2 SPOND (NCT01443845) multicenter, randomized, double-blind, placebo-controlled studies...
May 15, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29763359/are-sleep-alterations-the-cause-of-icu-delirium
#12
Arnaud W Thille, Faustine Reynaud, Damien Marie, Stéphanie Barrau, Ludivine Rousseau, Christophe Rault, Xavier Drouot
No abstract text is available yet for this article.
May 15, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29763340/reply-to-are-sleep-alterations-the-cause-of-icu-delirium
#13
Yoanna Skrobik, John W Devlin
No abstract text is available yet for this article.
May 15, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29763335/nintedanib-in-severe-pulmonary-arterial-hypertension
#14
Manuel J Richter, Jan Ewert, Friedrich Grimminger, Hossein Ardeschir Ghofrani, Baktybek Kojonazarov, Aleksandar Petrovic, Werner Seeger, Ralph T Schermuly, Khodr Tello, Henning Gall
No abstract text is available yet for this article.
May 15, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29758168/increasing-physical-activity-in-copd-one-step-at-a-time
#15
Denis E O'Donnell
No abstract text is available yet for this article.
May 14, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29758167/myeloid-regulatory-cells-new-and-exciting-players-in-the-immunology-of-lung-cancer
#16
Zvi G Fridlender
No abstract text is available yet for this article.
May 14, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29758165/interferon-%C3%AE-ifn%C3%AE-a-driver-of-cough-hypersensitivity-pathways-in-chronic-cough
#17
Kian Fan Chung
No abstract text is available yet for this article.
May 14, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29757681/lung-resident-mesenchymal-stromal-cells-reveal-transcriptional-dynamics-of-lung-development-in-preterm-infants
#18
Ruggero Spadafora, Junjie Lu, Radhika S Khetani, Cheng Zhang, Aimee Iberg, Hu Li, Yang Shi, Paul Lerou
No abstract text is available yet for this article.
May 14, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29757660/airway-pressure-release-ventilation-aprv-a-therapy-in-search-of-a-disease
#19
Shekhar Venkataraman, John P Kinsella
No abstract text is available yet for this article.
May 14, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29756994/new-insights-into-complicated-grief-in-bereaved-family-members-approached-for-organ-donation
#20
James Downar
No abstract text is available yet for this article.
May 14, 2018: American Journal of Respiratory and Critical Care Medicine
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