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American Journal of Respiratory and Critical Care Medicine

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https://www.readbyqxmd.com/read/28926296/randomised-controlled-trial-of-urokinase-versus-placebo-for-non-draining-malignant-pleural-effusion
#1
Eleanor K Mishra, Amelia O Clive, Genevieve H Wills, Helen E Davies, Andrew E Stanton, Mohamed Al-Aloul, Alan Hart-Thomas, Justin Pepperell, Matthew Evison, Tarek Saba, Richard Neil Harrison, Anur Guhan, Matthew E Callister, Ramamurthy Sathyamurthy, Sunita Rehal, John P Corcoran, Robert Hallifax, Ioannis Psallidas, Nicky Russell, Rachel Shaw, Melissa Dobson, John M Wrightson, Alex West, Y C Gary Lee, Andrew J Nunn, Robert F Miller, Nick A Maskell, Najib M Rahman
RATIONALE: Patients with malignant pleural effusion (MPE) experience breathlessness, which is treated by drainage and pleurodesis. Incomplete drainage results in residual dyspnea and pleurodesis failure. Intrapleural fibrinolytics lyse septations within pleural fluid, improving drainage. OBJECTIVES: To assess the effects of intrapleural urokinase on dyspnea and pleurodesis success in patients with non-draining malignant effusion. METHODS: Prospective double blind randomised trial; patients with non-draining effusion were randomly allocated 1:1 to intrapleural urokinase (100,000 IU three doses 12 hourly) or matched placebo...
September 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28926283/more-options-for-treating-severe-hyperinflation-in-advanced-emphysema
#2
Gerard Criner
No abstract text is available yet for this article.
September 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28926280/mepolizumab-attenuates-airway-eosinophil-numbers-but-not-their-functional-phenotype-in-asthma
#3
Gail M Gauvreau, Roma Sehmi
No abstract text is available yet for this article.
September 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28926279/telemedicine-a-key-tool-for-improving-cpap-adherence-in-sleep-apnea-patients
#4
Ramon Farré, Daniel Navajas, Josep M Montserrat
No abstract text is available yet for this article.
September 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28925740/household-air-pollution-is-associated-with-altered-cardiac-function-among-women-in-kenya
#5
Anubha Agarwal, Kipruto Kirwa, Melissa N Eliot, Fawaz Alenezi, Diana Menya, Sumeet S Mitter, Eric J Velazquez, Rajesh Vedanthan, Gregory A Wellenius, Gerald S Bloomfield
No abstract text is available yet for this article.
September 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28925717/reply-to-low-lung-function-in-young-adult-life-is-associated-with-early-mortality
#6
Monica M Vasquez, Muhan Zhou, Chengcheng Hu, Fernando D Martinez, Stefano Guerra
No abstract text is available yet for this article.
September 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28925714/low-lung-function-in-young-adult-life-is-associated-with-early-mortality
#7
Andrew Bush
No abstract text is available yet for this article.
September 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28915080/weight-adjusted-intravenous-reslizumab-in-severe-asthma-with-inadequate-response-to-fixed-dose-subcutaneous-mepolizumab
#8
Manali Mukherjee, Fernando Aleman Paramo, Melanie Kjarsgaard, Brittany Salter, Gayatri Nair, Nicola LaVigne, Katherine Radford, Roma Sehmi, Parameswaran Nair
BACKGROUND: Clinical benefits of fixed-dose 100 mg subcutaneous (SC) mepolizumab in prednisone-dependent patients are modest when sputum eosinophilia is not adequately controlled. This study compared treatment response of weight-adjusted intravenous (IV) Reslizumab in patients previously treated with 100 mg SC Mepolizumab. METHOD: 10 prednisone-dependent asthmatics (sputum eosinophils >3% and blood eosinophils > 300cells/μL), who had previously received Mepolizumab (100 mg SC Q4W) for at least 1 year, received two infusions of placebo (Q4W) followed by 4 infusions of 3...
September 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28915062/a-recombinant-fragment-of-human-surfactant-protein-d-suppresses-basophil-activation-th2-and-b-cell-responses-in-grass-pollen-induced-allergic-inflammation
#9
Asif S Qaseem, Iesha Singh, Ansar A Pathan, Janice A Layhadi, Rebecca Parkin, Fedina Alexandra, Stephen R Durham, Uday Kishore, Mohamed H Shamji
RATIONALE: rfhSP-D has been shown to suppress house dust mite and Aspergillus fumigatus-induced allergic inflammation in murine models. OBJECTIVES: We sought to elucidate the effect of rfhSP-D on FcεRI and CD23-mediated grass pollen induced allergic inflammatory responses. METHODS: rfhSP-D, containing homotrimeric neck and lectin domains, was expressed in Escherichia coli BL21 (λDE3) pLysS. PBMCs and sera were obtained from grass pollen allergic individuals (n=27)...
September 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28910144/ask1-inhibition-halts-disease-progression-in-preclinical-models-of-pulmonary-arterial-hypertension
#10
Grant R Budas, Mario Boehm, Baktybek Kojonazarov, Gayathri Viswanathan, Xia Tian, Swathi Veeroju, Tatyana Novoyatleva, Friedrich Grimminger, Ford Hinojosa-Kirschenbaum, Hossein A Ghofrani, Norbert Weissmann, Werner Seeger, John T Liles, Ralph T Schermuly
RATIONALE Progression of pulmonary arterial hypertension (PAH) is associated with pathologic remodeling of the pulmonary vasculature and the right ventricle (RV). Oxidative stress drives the remodeling process through activation of mitogenactivated protein kinases (MAPKs) which stimulate apoptosis, inflammation and fibrosis. OBJECTIVES We investigated whether pharmacological inhibition of the redoxsensitive apical MAPK Apoptosis Signal-Regulating Kinase 1 (ASK1) can halt the progression of pulmonary vascular and RV remodeling...
September 14, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28910137/the-role-of-s1pr3-in-protection-from-bacterial-sepsis
#11
Barry S Shea, Steven M Opal
No abstract text is available yet for this article.
September 14, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28910134/eosinophilic-and-non-eosinophilic-asthma
#12
Tara F Carr, Amir A Zeki, Monica Kraft
Asthma can be subdivided into eosinophilic or non-eosinophilic phenotypes based on the inflammatory cellular patterns seen in sputum, blood, and airway tissue compartments. However, this level of stratification does not always produce robust clinical phenotypes as there is considerable overlap across these phenotypes when viewed from the perspective of "eosinophilia". Multiple proposed subphenotypes of asthma have instead been described within both the eosinophilic and non-eosinophilic groups. An endotype is the mechanism driving a subphenotype including those associated with eosinophilia such as early-onset allergic asthma, with and without obesity, aspirin sensitive asthma and late-onset eosinophilic asthma, allergic bronchopulmonary mycosis, and exercise-induced asthma...
September 14, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28910131/lung-tissue-injury-as-atypical-response-to-nivolumab-in-nsclc
#13
Cristiano Rampinelli, Gianluca Spitaleri, Antonio Passaro, Alessia Pochesci, Eleonora Ancona, Filippo De Marinis
No abstract text is available yet for this article.
September 14, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28902529/evaluation-of-the-2016-infectious-diseases-society-of-america-american-thoracic-society-guideline-criteria-for-risk-of-multi-drug-resistant-pathogens-in-hospital-acquired-and-ventilator-associated-pneumonia-patients-in-the-intensive-care-unit
#14
Pervin Korkmaz Ekren, Otavio T Ranzani, Adrian Ceccato, Gianluigi Li Bassi, Eva Muñoz Conejero, Miquel Ferrer, Michael S Niederman, Antoni Torres
No abstract text is available yet for this article.
September 13, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28895752/airflow-obstruction-and-use-of-solid-fuels-for-cooking-or-heating-bold-results
#15
André F S Amaral, Jaymini Patel, Bernet S Kato, Daniel O Obaseki, Hervé Lawin, Wan C Tan, Sanjay K Juvekar, Imed Harrabi, Michael Studnicka, Emiel F M Wouters, Li-Cher Loh, Eric D Bateman, Kevin Mortimer, A Sonia Buist, Peter G J Burney
RATIONALE: Evidence supporting the association of COPD or airflow obstruction with use of solid fuels is conflicting and inconsistent. OBJECTIVE: To assess the association of airflow obstruction with self-reported use of solid fuels for cooking or heating. METHODS: We analysed 18,554 adults from the BOLD study, who had provided acceptable post-bronchodilator spirometry measurements and information on use of solid fuels. The association of airflow obstruction with use of solid fuels for cooking or heating was assessed by sex, within each site, using regression analysis...
September 12, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28892454/disease-staging-and-prognosis-in-smokers-using-deep-learning-in-chest-computed-tomography
#16
Germán González, Samuel Y Ash, Gonzalo Vegas Sanchez-Ferrero, Jorge Onieva Onieva, Farbod N Rahaghi, James C Ross, Alejandro Díaz, Raúl San José Estépar, George R Washko
RATIONALE: Deep learning is a powerful tool that may allow for improved outcome prediction. OBJECTIVES: To determine if deep learning, specifically convolutional neural network (CNN) analysis, could detect and stage chronic obstructive pulmonary disease (COPD) and predict acute respiratory disease events (ARD) and mortality in smokers. METHODS: A CNN was trained using CT scans from 7,983 COPDGene participants and evaluated using 1000 non-overlapping COPDGene participants and 1,672 ECLIPSE participants...
September 11, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28892403/plexiform-vasculopathy-in-chronic-thromboembolic-pulmonary-hypertension
#17
Maximilian Ackermann, Andreas Gaumann, Steven J Mentzer, Jan B Hinrichs, Gregor Warnecke, Marius M Hoeper, Peter Braubach, Mark Kuehnel, Lavinia Maegel, Danny Jonigk
No abstract text is available yet for this article.
September 11, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28892401/pulmonary-cryptococcus-presenting-as-a-solitary-pulmonary-nodule
#18
Sivakumar Sudhakaran, Lara Bashoura, John Stewart, Diwakar D Balachandran, Saadia A Faiz
No abstract text is available yet for this article.
September 11, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28891674/reply-to-sepsis-3-in-community-acquired-pneumonia-how-reliable-is-it
#19
Otavio T Ranzani, Antoni Torres
No abstract text is available yet for this article.
September 11, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28891672/sepsis-3-in-community-acquired-pneumonia-how-reliable-is-it
#20
Karolina Akinosoglou, Charalambos Gogos
No abstract text is available yet for this article.
September 11, 2017: American Journal of Respiratory and Critical Care Medicine
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