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American Journal of Respiratory and Critical Care Medicine

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https://www.readbyqxmd.com/read/30409023/preventative-inhalation-of-hypertonic-saline-in-infants-with-cystic-fibrosis-presis-a-randomized-double-blind-controlled-study
#1
Mirjam Stahl, Mark O Wielpütz, Isabell Ricklefs, Christian Dopfer, Sandra Barth, Anne Schlegtendal, Simon Y Graeber, Olaf Sommerburg, Gesa Diekmann, Johannes Hüsing, Cordula Koerner-Rettberg, Lutz Nährlich, Anna-Maria Dittrich, Matthias V Kopp, Marcus A Mall
RATIONALE: Cystic fibrosis (CF) lung disease starts in early infancy suggesting that preventive treatment may be most beneficial. Lung clearance index (LCI) and chest magnetic resonance imaging (MRI) have emerged as promising endpoints of early CF lung disease, however, randomized controlled trials testing the safety and efficacy of preventive therapies in infants with CF are lacking. OBJECTIVES: To determine feasibility, safety and efficacy of preventive inhalation with hypertonic saline (HS) compared to isotonic saline (IS) in infants with CF including LCI and MRI as outcome measures...
November 9, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30407846/pulmonary-function-from-genome-wide-association-studies-to-genome-wide-interaction-studies
#2
David C Christiani
No abstract text is available yet for this article.
November 8, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30407844/transcriptome-analysis-of-sputum-cells-the-modern-art-of-assessing-inflammation
#3
Christian Taube, Sebastian Reuter
No abstract text is available yet for this article.
November 8, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30407843/new-biologics-for-severe-asthma-what-patients-what-agents-what-results-at-what-cost
#4
Klaus F Rabe
No abstract text is available yet for this article.
November 8, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30407842/congenital-vertical-tracheal-septum-misdiagnosed-as-laryngomalacia
#5
Karl Reiter, Johanna Kramer, Matthias Griese, Birgit Kammer
No abstract text is available yet for this article.
November 8, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30407838/balanced-crystalloid-solutions
#6
Matthew W Semler, John A Kellum
Intravenous fluid therapy is the most common intervention received by acutely ill patients. Historically, saline (0.9% sodium chloride) has been the most frequently administered intravenous fluid, especially in North America. Balanced crystalloid solutions (e.g., lactated Ringer's, Plasma-Lyte) are an increasingly used alternative to saline. Balanced crystalloids have a sodium, potassium, and chloride content closer to that of extra-cellular fluid and, when given intravenously, have fewer adverse effects on acid-base balance...
November 8, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30398927/multidimensional-assessment-of-the-host-response-in-mechanically-ventilated-patients-with-suspected-pneumonia
#7
James M Walter, Ziyou Ren, Tyrone Yacoub, Paul A Reyfman, Raj D Shah, Hiam Abdala-Valencia, Kiwon Nam, Vince K Morgan, Kishore R Anekalla, Nikita Joshi, Alexandra C McQuattie-Pimentel, Ching-I Chen, Monica Chi, SeungHye Han, Francisco J Gonzalez-Gonzalez, Saul Soberanes, Raul P Aillon, Satoshi Watanabe, Kinola J N Williams, Ziyan Lu, Joseph Paonessa, Peter Hountras, Madonna Breganio, Nicole Borkowski, Helen K Donnelly, Jonathan P Allen, Luis A Amaral, Ankit Bharat, Alexander V Misharin, Neda Bagheri, Alan R Hauser, G R Scott Budinger, Richard G Wunderink
RATIONALE: The identification of informative elements of the host response to infection may improve the diagnosis and management of bacterial pneumonia. OBJECTIVE: To determine whether the absence of alveolar neutrophilia can exclude bacterial pneumonia in critically ill patients with suspected infection and to test whether signatures of bacterial pneumonia can be identified in the alveolar macrophage transcriptome. METHODS: We determined the test characteristics of alveolar neutrophilia for the diagnosis of bacterial pneumonia in 3 cohorts of mechanically ventilated patients...
November 6, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30398910/high-peep-only-a-dam-against-edema-formation-probably-not-again
#8
Alessandro Santini, Giacomo E Iapichino, Alessandro Protti
No abstract text is available yet for this article.
November 6, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30398896/precision-medicine-in-acute-kidney-injury-a-promising-future
#9
Jennifer A Schaub, Michael Heung
No abstract text is available yet for this article.
November 6, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30398892/reply-to-high-peep-only-a-dam-against-edema-formation-probably-not-again
#10
Bhushan H Katira, Wolfgang M Kuebler, Kim A Connelly, Brian P Kavanagh
No abstract text is available yet for this article.
November 6, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30395729/pharmacologic-exhaustion-of-suppressor-cells-with-tasquinimod-enhances-bacterial-clearance-during-tb
#11
Shashank Gupta, Stefanie Krug, Supriya Pokkali, Tomas Leanderson, John T Isaacs, Geetha Srikrishna, William R Bishai
No abstract text is available yet for this article.
November 5, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30395723/pulmonary-vascular-disease-in-premature-infants-early-predictive-models-of-late-respiratory-morbidity
#12
Philip T Levy, Roberta L Keller
No abstract text is available yet for this article.
November 5, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30395720/letting-it-all-out-neutrophils-in-early-cf-airway-inflammation
#13
Lucy Perrem, Felix Ratjen
No abstract text is available yet for this article.
November 5, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30395486/the-combination-of-atomoxetine-and-oxybutynin-greatly-reduces-obstructive-sleep-apnea-severity-a-randomized-placebo-controlled-double-blind-crossover-trial
#14
Luigi Taranto-Montemurro, Ludovico Messineo, Scott A Sands, Ali Azarbarzin, Melania Marques, Bradley A Edwards, Danny J Eckert, David P White, Andrew Wellman
RATIONALE: There is currently no effective pharmacological treatment for obstructive sleep apnea (OSA). Recent investigations indicate that drugs with noradrenergic and antimuscarinic effects improve genioglossus muscle activity and upper airway patency during sleep. OBJECTIVES: We aimed to determine the effects of the combination of a norepinephrine reuptake inhibitor (atomoxetine) and an antimuscarinic (oxybutynin) on OSA severity (apnea-hypopnea index, AHI; primary outcome) and genioglossus responsiveness (secondary outcome) in people with OSA...
November 5, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30384774/rural-residence-and-poverty-are-independent-risk-factors-for-copd-in-the-united-states
#15
Sarath Raju, Corinne A Keet, Laura M Paulin, Elizabeth C Matsui, Roger D Peng, Nadia N Hansel, Meredith C McCormack
RATIONALE: In developing countries, poor and rural areas have a high burden of Chronic Obstructive Pulmonary Disease(COPD), with environmental pollutants and the indoor burning of biomass implicated as potential causal exposures. Less is known about the prevalence of COPD in the United States with respect to urban-rural distribution, poverty, and factors that uniquely contribute to COPD amongst never-smokers. OBJECTIVES: To understand the impact of urban-rural status, poverty and other community factors on COPD prevalence nationwide and amongst never-smokers...
November 2, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30383410/ezrin-in-asthma-a-first-step-to-early-biomarkers-of-airway-epithelial-dysfunction
#16
Qun Wu, Oliver Eickelberg
No abstract text is available yet for this article.
November 1, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30383401/unusual-cause-of-severe-airflow-limitation-in-a-patient-with-eisenmenger-s-syndrome
#17
Brandon Nokes, Eric A Jensen, Rodrigo Cartin-Ceba
No abstract text is available yet for this article.
November 1, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30383400/can-a-physiologic-insight-resuscitate-research-in-cpr
#18
Damon C Scales, Brian P Kavanagh
No abstract text is available yet for this article.
November 1, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30383395/bmp9-morphs-into-a-potential-player-in-portopulmonary-hypertension
#19
Mark Toshner
No abstract text is available yet for this article.
November 1, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30376357/reply-to-the-diagnostic-failures-in-asthma
#20
Shawn D Aaron
No abstract text is available yet for this article.
October 30, 2018: American Journal of Respiratory and Critical Care Medicine
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