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American Journal of Respiratory and Critical Care Medicine

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https://www.readbyqxmd.com/read/28441043/hydro-pneumothorax-from-a-ruptured-coccidioides-cavity
#1
Charles W Lanks
No abstract text is available yet for this article.
April 25, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28441027/cardiac-morphometry-on-computed-tomography-and-exacerbation-reduction-with-%C3%AE-blocker-therapy-in-copd
#2
Surya P Bhatt, Gonzalo Vegas-Sánchez-Ferrero, Farbod N Rahaghi, Erick S MacLean, German Gonzalez-Serrano, Carolyn E Come, Gregory L Kinney, John E Hokanson, Matthew J Budoff, Michael J Cuttica, J Michael Wells, Raúl San José Estépar, George R Washko
No abstract text is available yet for this article.
April 25, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28430547/enhancing-insights-into-pulmonary-vascular-disease-pvd-through-a-precision-medicine-approach-a-joint-nhlbi-cmref-workshop-report
#3
John H Newman, Stuart Rich, Steven H Abman, John H Alexander, John Barnard, Gerald J Beck, Raymond L Benza, Todd M Bull, Stephen Y Chan, Hyung J Chun, Declan Doogan, Jocelyn Dupuis, Serpil C Erzurum, Robert P Frantz, Mark Geraci, Hunter Gillies, Mark Gladwin, Michael P Gray, Anna R Hemnes, Roy S Herbst, Adrian F Hernandez, Nicholas S Hill, Evelyn M Horn, Kendall Hunter, Zhi-Cheng Jing, Roger Johns, Sanjay Kaul, Steven M Kawut, Tim Lahm, Jane A Leopold, Greg D Lewis, Stephen C Mathai, Vallerie V McLaughlin, Evangelos D Michelakis, Steven D Nathan, William Nichols, Grier Page, Marlene Rabinovitch, Jonathan Rich, Franz Rischard, Sharon Rounds, Sanjiv J Shah, Victor F Tapson, Naomi Lowy, Norman Stockbridge, Gail Weinmann, Lei Xiao
The Division of Lung Diseases of the National Heart, Lung and Blood Institute, (NHLBI) and the Cardiovascular Medical Education and Research Fund (CMREF), held a workshop to discuss to leverage of the anticipated scientific output from the recently launched "Redefining Pulmonary Hypertension (PH) through Pulmonary Vascular Disease Phenomics" (PVDOMICS) program. PVDOMICS is a protocol driven network to analyze PH patient populations to define novel pulmonary vascular disease (PVD) phenotypes. Basic, translational and clinical investigators, patient advocacy organizations, regulatory agencies, and pharmaceutical industry experts discussed the application of precision medicine to PVD clinical trials...
April 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28423284/controlled-clinical-trials-and-real-life-experience-with-pulmonary-rehabilitation
#4
Gayathri Sathiyamoorthy, Christopher Lau, Scott Marlow, Umur Hatipoğlu
No abstract text is available yet for this article.
April 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28423283/reply-to-controlled-clinical-trials-and-real-life-experience-with-pulmonary-rehabilitation
#5
Maria-Rosa Güell, Bartolome Celli
No abstract text is available yet for this article.
April 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28422515/allergen-induced-increases-in-sputum-levels-of-group-2-innate-lymphoid-cells-in-asthmatic-subjects
#6
Ruchong Chen, Steven G Smith, Brittany Salter, Amani El-Gammal, John Paul Oliveria, Caitlin Obminski, Rick Watson, Paul M O'Byrne, Gail M Gauvreau, Roma Sehmi
RATIONALE: Group 2 innate lymphoid cells (ILC2), a major source of type 2 cytokines, initiate eosinophilic inflammatory responses in murine models of asthma. OBJECTIVES: Investigate the role of ILC2 in allergen-induced airway eosinophilic responses in atopic asthmatics. METHODS: Using a diluent-controlled allergen challenge cross-over study, where all subjects (n=10) developed allergen-induced early and late responses , airway eosinophilia and increased methacholine airway responsiveness, bone marrow, blood and sputum samples were collected pre- and post-inhalation challenge...
April 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28422514/vitamin-c-prevents-offspring-dna-methylation-changes-associated-with-maternal-smoking-in-pregnancy
#7
Lyndsey E Shorey-Kendrick, Cindy T McEvoy, Betsy Ferguson, Julja Burchard, Byung S Park, Lina Gao, Brittany H Vuylsteke, Kristin F Milner, Cynthia D Morris, Eliot R Spindel
BACKGROUND: Infants whose mothers smoked during pregnancy demonstrate lifelong decreases in pulmonary function. DNA methylation changes associated with maternal smoking during pregnancy have been described in placenta and cord blood at delivery, in fetal lung, and in buccal epithelium and blood during childhood. We recently demonstrated in a randomized clinical trial (NCT00632476) that vitamin C supplementation to pregnant smokers can lessen the impact of maternal smoking on offspring pulmonary function and decrease the incidence of wheeze at one year of age...
April 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28418699/candida-endocarditis-presenting-as-acute-myocardial-infarction
#8
Anirudh Aron, Upasna Manchanda-Aron, Amado X Freire
No abstract text is available yet for this article.
April 18, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28418697/a-two-biomarker-model-predicts-mortality-in-the-critically-ill-with-sepsis
#9
Carmen Mikacenic, Brenda L Price, Susanna Harju-Baker, D Shane O'Mahony, Cassianne Robinson-Cohen, Frank Radella, William O Hahn, Ronit Katz, David C Christiani, Jonathan Himmelfarb, W Conrad Liles, Mark M Wurfel
RATIONALE: Improving the prospective identification of patients with the systemic inflammatory response syndrome (SIRS) and sepsis at low for organ dysfunction and death is a major clinical challenge. OBJECTIVE: To develop and validate a multi-biomarker based prediction model for 28-day mortality in critically ill patients with SIRS and sepsis. METHODS: The derivation cohort (n=888) and internal test cohort (n=278) were from a prospective study of critically ill intensive care unit (ICU) patients meeting 2 of 4 SIRS criteria at an academic medical center for whom plasma was obtained within 24 hours...
April 18, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28414524/a-standardized-diagnostic-ontology-for-fibrotic-interstitial-lung-disease-an-international-working-group-perspective
#10
Christopher J Ryerson, Tamera J Corte, Joyce S Lee, Luca Richeldi, Simon L F Walsh, Jeffrey L Myers, Juergen Behr, Vincent Cottin, Sonye K Danoff, Kevin R Flaherty, David J Lederer, David A Lynch, Fernando J Martinez, Ganesh Raghu, William D Travis, Zarir Udwadia, Athol U Wells, Harold R Collard
Diagnosing fibrotic interstitial lung disease (ILD) requires multidisciplinary integration of clinical, radiological, and pathological features with assignment of a consensus classification. The current approach lacks a standardized ontology and therefore results in diagnostic heterogeneity. The objectives of this international working group perspective are to describe limitations of the current approach to fibrotic ILD diagnosis and to develop an ontological framework for standardizing the diagnostic classification...
April 17, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28414520/rare-genetic-variants-in-parn-are-associated-with-pulmonary-fibrosis-in-families
#11
Jonathan A Kropski, Sara Reiss, Cheryl Markin, Kevin K Brown, David A Schwartz, Marvin I Schwarz, James E Loyd, John A Phillips Iii, Timothy S Blackwell, Joy D Cogan
No abstract text is available yet for this article.
April 17, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28410569/phenotypes-of-rapid-cystic-fibrosis-lung-disease-progression-during-adolescence-and-young-adulthood
#12
Rhonda D Szczesniak, Dan Li, Weiji Su, Cole Brokamp, John Pestian, Michael Seid, John P Clancy
RATIONALE: Individuals with cystic fibrosis are at risk for prolonged drops in lung function, clinically termed rapid decline, during discreet periods of the disease. OBJECTIVES: To identify phenotypes of rapid pulmonary decline and determine how these phenotypes are related to patient characteristics. METHODS: A longitudinal cohort study of cystic fibrosis patients aged 6-21 years was conducted using the Cystic Fibrosis Foundation Patient Registry...
April 14, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28410559/the-irony-of-iron-overload-and-iron-deficiency-in-chronic-obstructive-pulmonary-disease
#13
Suzanne M Cloonan, Sharon Mumby, Ian M Adcock, Augustine M K Choi, Kian Fan Chung, Gregory J Quinlan
Chronic obstructive pulmonary disease (COPD) is a debilitating inflammatory lung disease associated with cigarette smoking and is third leading cause of death worldwide. With the recent emergence of genome wide association studies (GWAS), the identification of multiple COPD susceptibility genes has enhanced and expanded our understanding of the pathogenic mechanisms associated with this debilitating lung disease. An example of such a pathogenic mechanism is the role of iron metabolism in the onset and progression of COPD...
April 14, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28406724/fifty-years-of-research-in-ards-gas-exchange-in-acute-respiratory-distress-syndrome
#14
Peter Radermacher, Salvatore Maurizio Maggiore, Alain Mercat
The acute respiratory distress syndrome (ARDS) is characterized by severe impairment of gas exchange. Hypoxemia is mainly due to intrapulmonary shunt, while increased alveolar dead space explains the alteration of CO2 clearance. Assessment of the severity of gas exchange impairment is a requisite for the characterization of the syndrome and the evaluation of its severity. Confounding factors linked to hemodynamic status can greatly influence the relationship between the severity of lung injury and the degree of hypoxemia and/or the effects of ventilator settings on gas exchange...
April 13, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28406712/reply-to-next-step-to-understand-subphenotypes-of-acute-respiratory-distress-syndrome
#15
Carolyn S Calfee, Kevin Delucchi, Katie R Famous
No abstract text is available yet for this article.
April 13, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28406711/next-step-to-understand-subphenotypes-of-acute-respiratory-distress-syndrome
#16
Tatsutoshi Shimatani, Shinichiro Ohshimo, Nobuaki Shime
No abstract text is available yet for this article.
April 13, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28399379/physiology-of-arousal-in-osa-and-potential-impacts-for-sedative-treatment
#17
Amy S Jordan, Fergal J O'Donoghue, Jennifer M Cori, John Trinder
Treatment options for patients with obstructive sleep apnea (OSA) intolerant of continuous positive airway pressure (CPAP) are limited. Thus, new therapies are sought. Recently, there has been interest in using sedatives to delay arousal from sleep, allowing upper airway dilator muscle recruitment sufficient to re-open the airway while maintaining sleep. In this review the rationale for sedative use and prior sedative studies in OSA are presented, along with a description of six factors that may determine sedative treatment success...
April 11, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28398067/kaposiform-lymphangiomatosis-with-human-papilloma-virus-infection
#18
Elżbieta Radzikowska, Katarzyna Błasińska-Przerwa, Małgorzata Szołkowska, Agnieszka Miąsko, Włodzimierz Kupis, Elżbieta Wiatr
No abstract text is available yet for this article.
April 11, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28387538/the-voice-of-surrogate-decision-makers-family-responses-to-prognostic-information-in-chronic-critical-illness
#19
Judith E Nelson, Laura C Hanson, Kristine L Keller, Shannon S Carson, Christopher E Cox, James A Tulsky, Douglas B White, Emily J Chai, Stefanie P Weiss, Marion Danis
RATIONALE: Information from clinicians about the expected course of the patient's illness is relevant and important for decision-making by surrogates for chronically critically ill patients on mechanical ventilation. OBJECTIVE: Observe how surrogates of chronically critically ill patients respond to information about prognosis from palliative care clinicians. METHODS: Qualitative analysis of a consecutive sample of audio-recorded meetings from a larger, multisite, randomized trial of structured informational and supportive meetings led by a palliative care physician and nurse practitioner for surrogates of patients in Medical Intensive Care Units with chronic critical illness (i...
April 7, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28387526/influenza-associated-aspergillosis-in-critically-ill-patients
#20
Frank L van de Veerdonk, Eva Kolwijck, Pieter P A Lestrade, Caspar J Hodiamont, Bart J A Rijnders, Judith van Paassen, Pieter-Jan Haas, Claudy Oliveira Dos Santos, Greetje A Kampinga, Dennis C J J Bergmans, Karin van Dijk, Anton F J de Haan, Jaap van Dissel, Hans G van der Hoeven, Paul E Verweij
No abstract text is available yet for this article.
April 7, 2017: American Journal of Respiratory and Critical Care Medicine
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