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American Journal of Respiratory and Critical Care Medicine

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https://www.readbyqxmd.com/read/28339287/rapid-radiologic-progression-of-silicosis
#1
Kazuo Tsuchiya, Mikio Toyoshima, Norimichi Akiyama, Masato Kono, Yutaro Nakamura, Kazuhito Funai, Satoshi Baba, Haruhiko Sugimura, Hitomi Kanayama, Takafumi Suda
No abstract text is available yet for this article.
March 24, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28328243/factors-associated-with-bleeding-and-thrombosis-in-children-receiving-extracorporeal-membrane-oxygenation-ecmo
#2
Heidi J Dalton, Ron Reeder, Pamela Garcia-Filion, Richard Holubkov, Robert A Berg, Athena Zuppa, Frank W Moler, Thomas Shanley, Murray M Pollack, Christopher Newth, John Berger, David Wessel, Joseph Carcillo, Michael Bell, Sabrina Heidemann, Kathleen L Meert, Richard Harrison, Allan Doctor, Robert F Tamburro, J Michael Dean, Tammara Jenkins, Carol Nicholson
RATIONALE: Extracorporeal membrane oxygenation (ECMO) is employed for respiratory and cardiac failure in children but is complicated by bleeding and thrombosis. OBJECTIVES: (1) Measure the incidence of bleeding (blood loss requiring transfusion or intracranial hemorrhage) and thrombosis during ECMO support; (2) identify factors associated with these complications; and (3) determine the impact of these complications on patient outcome. METHODS: Prospective, observational cohort study in pediatric, cardiac, and neonatal intensive care units in eight hospitals from December 2012 to September 2014...
March 22, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28328237/magnetic-resonance-imaging-in-the-prognostic-evaluation-of-patients-with-pulmonary-arterial-hypertension
#3
Andrew J Swift, Dave Capener, Chris Johns, Neil Hamilton, Alex Rothman, Charlie Elliot, Robin Condliffe, Athanasios Charalampopoulos, Smitha Rajaram, Allan Lawrie, Michael J Campbell, Jim M Wild, David G Kiely
RATIONALE: Prognostication is important when counselling patients and defining treatment strategies in pulmonary arterial hypertension (PAH). OBJECTIVE: To determine the value of MRI metrics for prediction of mortality in PAH. METHODS: Consecutive patients with PAH undergoing MRI were identified from the ASPIRE-Pulmonary-Hypertension-Registry. MEASUREMENTS AND MAIN RESULTS: During the follow-up period of 42 (range 17-142) months 576 patients were studied and 221 (38%) died...
March 22, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28324661/improved-risk-stratification-in-pediatric-septic-shock-using-both-protein-and-mrna-biomarkers-persevere-xp
#4
Hector R Wong, Natalie Z Cvijanovich, Nick Anas, Geoffrey L Allen, Neal J Thomas, Michael T Bigham, Scott L Weiss, Julie C Fitzgerald, Paul A Checchia, Keith Meyer, Michael Quasney, Mark Hall, Rainer Gedeit, Robert J Freishtat, Jeffrey Nowak, Shekhar S Raj, Shira Gertz, Jocelyn R Grunwell, Christopher J Lindsell
RATIONALE: We previously derived and validated the Pediatric Sepsis Biomarker Risk Model (PERSEVERE) to estimate baseline mortality risk in children with septic shock. The PERSEVERE biomarkers are serum proteins, selected from among the proteins directly related to 80 mortality risk assessment genes. The initial approach to selecting the PERSEVERE biomarkers left 68 genes unconsidered. OBJECTIVE: Determine if the 68 previously unconsidered genes can improve upon the performance of PERSEVERE and provide biological information regarding the pathophysiology of septic shock...
March 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28323453/tuberculosis-treatment-outcomes-in-europe-based-on-treatment-completion-not-cure
#5
Martin J Dedicoat, Gunar Günther, Valeriu Crudu, Raquel Duarte, Gina Gualano, Cecile Magis-Escurra, Rudolf Rumetshofer, Alena Skrahina, Victor Spinu, Simon Tiberi, Piret Viiklepp, Frank van Leth, Christoph Lange
No abstract text is available yet for this article.
March 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28323433/increased-cd13-expression-in-acute-myeloid-leukemia-associated-early-acute-hypoxic-respiratory-failure
#6
Coursen Schneider, Michael Bayerl, Cinda Boyer, Ruchi Desai, David Claxton, Andry Van de Louw
No abstract text is available yet for this article.
March 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28306336/fifty-years-of-research-in-ards-cell-based-therapy-for-ards-biology-and-potential-therapeutic-value
#7
John G Laffey, Michael A Matthay
Based on several pre-clinical studies, cell-based therapy has emerged as a potential new therapeutic for ARDS. Of the various cell-based therapy options, mesenchymal stromal cells (MSCs) from bone marrow, adipose tissue and umbilical cord have the most experimental data to support their potential efficacy for lung injury from both infectious and non-infectious causes. Mechanistically, MSCs exert their beneficial effects by release of paracrine factors, microvesicles, and transfer of mitochondria, all of which have anti-inflammatory and pro-resolving effects on injured lung endothelium and alveolar epithelium, including enhancing the resolution of pulmonary edema by upregulating sodium-dependent alveolar fluid clearance...
March 17, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28306327/fifty-years-of-research-in-ards-respiratory-mechanics-in-acute-respiratory-distress-syndrome
#8
William R Henderson, Lu Chen, Marcelo B P Amato, Laurent J Brochard
Acute respiratory distress syndrome is a multifactorial lung injury that continues to be associated with high levels of morbidity and mortality. Mechanical ventilation, while lifesaving, is associated with new iatrogenic injury. Current best practice involves the use of small tidal volumes, low plateau and driving pressures, and high levels of positive end expiratory pressure. Collectively, these interventions are termed "lung protective ventilation". Recent investigations suggest that individualized measurements of pulmonary mechanical variables rather than population based ventilation prescriptions may be used to set the ventilator with the potential to improve outcomes beyond those achieved with standard lung protective ventilation...
March 17, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28306326/classification-of-airflow-limitation-based-on-z-score-underestimates-mortality-in-patients-with-chronic-obstructive-pulmonary-disease
#9
Elena Tejero, Eva Prats, Raquel Casitas, Raúl Galera, Paloma Pardo, Adelaida Gavilán, Elisabet Martínez-Cerón, Carolina Cubillos-Zapata, Luis Del Peso, Francisco García-Río
RATIONALE: Global Lung Function Initiative recommends reporting lung function measures as z-score, and a classification of airflow limitation (AL) based on this parameter has recently been proposed. OBJECTIVE: To evaluate the prognostic capacity of the AL classifications based on z-score or percentage predicted in patients with chronic obstructive pulmonary disease (COPD). METHODS: A cohort of 2614 COPD patients recruited outside the hospital setting was examined after 57±13 months of follow-up, totalling 10,322 person-years...
March 17, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28306325/diffuse-subcutaneous-emphysema-following-tracheal-perforation
#10
Andrew Keenan, William Browne, Maneesh Bhargava
No abstract text is available yet for this article.
March 17, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28306322/recommended-reading-from-rutgers-robert-wood-johnson-medical-school-pulmonary-and-critical-care-medicine-fellows
#11
Sabiha Hussain, Sugeet Jagpal, Saqib H Baig, Edward K Len, Pallak Agarwal
No abstract text is available yet for this article.
March 17, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28306321/eosinophilia-frequent-exacerbations-and-steroid-response-in-chronic-obstructive-pulmonary-disease
#12
Peter M A Calverley, Kay Tetzlaff, Claus Vogelmeier, Leonardo M Fabbri, Helgo Magnussen, Emiel F M Wouters, William Mezzanotte, Bernd Disse, Helen Finnigan, Guus Asijee, Christoph Hallmann, Henrik Watz
No abstract text is available yet for this article.
March 17, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28296428/effect-of-cpap-therapy-on-the-cardiovascular-outcomes-in-patients-with-nonsleepy-obstructive-sleep-apnea
#13
Tomoyuki Kawada
No abstract text is available yet for this article.
March 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28296427/reply-to-effect-of-cpap-therapy-on-the-cardiovascular-outcomes-in-patients-with-nonsleepy-obstructive-sleep-apnea
#14
Yüksel Peker, Karl Wegscheider, Christine Eulenburg
No abstract text is available yet for this article.
March 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28288287/airway-necrosis-and-barotrauma-after-ecstasy-mdma-inhalation
#15
Evi Van den Kerckhove, Laurence Roosens, Vasiliki Siozopoulou, Walter Verbrugghe, Jelle Aerts, Jef Huyskens, Hannelore Raemen, Philippe G Jorens
No abstract text is available yet for this article.
March 13, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28288286/recommended-reading-from-the-newyork-presbyterian-hospital-weill-cornell-medicine-pulmonary-and-critical-care-medicine-fellows
#16
Kevin C Ma, Daniel S Jones, David R Price, Meredith L Turetz
No abstract text is available yet for this article.
March 13, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28288285/reply-to-official-ats-jrs-clinical-practice-guidelines-lymphangioleiomyomatosis-diagnosis-and-management
#17
Francis X McCormack, Nishant Gupta, Geraldine Finlay, Lisa R Young, Simon Johnson, Vincent Cottin, Kevin Wilson, Joel Moss
No abstract text is available yet for this article.
March 13, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28288282/official-ats-jrs-clinical-practice-guidelines-lymphangioleiomyomatosis-diagnosis-and-management
#18
Sergio Harari, Roberto Cassandro, Olga Torre
No abstract text is available yet for this article.
March 13, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28282501/preventing-severe-asthma-exacerbations-in-children-a-randomised-trial-of-mite-impermeable-bedcovers
#19
Clare S Murray, Phil Foden, Helen Sumner, Elizabeth Shepley, Adnan Custovic, Angela Simpson
RATIONALE: Allergen exposure in sensitised asthmatics interacts with viruses in increasing the risk of asthma exacerbation. OBJECTIVES: To evaluate the use of house dust mite impermeable bedding on severe asthma exacerbations in children. METHODS: We randomized mite-sensitised asthmatic children (3-17 years), following an emergency hospital attendance with an asthma exacerbation, to receive mite-impermeable (Active) or control (Placebo) bed encasings...
March 10, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28278391/blood-eosinophils-and-response-to-maintenance-copd-treatment-data-from-the-flame-trial
#20
Nicolas Roche, Kenneth R Chapman, Claus F Vogelmeier, Felix J F Herth, Chau Thach, Robert Fogel, Petter Olsson, Francesco Patalano, Donald Banerji, Jadwiga A Wedzicha
RATIONALE: Post-hoc analyses suggest that blood eosinophils have potential as a predictive biomarker of inhaled corticosteroid efficacy in the management of chronic obstructive pulmonary disease. OBJECTIVES: We prospectively investigated the value of blood eosinophils as a predictor of responsiveness to an inhaled corticosteroid/long-acting β2-agonist combination versus a long-acting β2-agonist/long-acting muscarinic antagonist combination for exacerbation prevention...
March 9, 2017: American Journal of Respiratory and Critical Care Medicine
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