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Journal of Natural Products

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https://www.readbyqxmd.com/read/28099011/montagnuphilones-a-g-azaphilones-from-montagnulaceae-sp-dm0194-a-fungal-endophyte-of-submerged-roots-of-persicaria-amphibia
#1
Jian-Guang Luo, Ya-Ming Xu, Dustin C Sandberg, A Elizabeth Arnold, A A Leslie Gunatilaka
Seven azaphilones, montagnuphilones A-G (1-7), together with previously known azaphilones 8-11, were encountered in Montagnulaceae sp. DM0194, an endophytic fungus isolated from submerged roots of Persicaria amphibia. The structures of 1-7 were elucidated on the basis of their MS and NMR spectroscopic analysis. Compounds 1-8 were evaluated for their cytotoxicity and ability to inhibit nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophage cells. Among these, none were found to be cytotoxic to RAW264...
January 18, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28099006/constituents-of-the-rhizomes-of-boesenbergia-pandurata-and-their-antiausterity-activities-against-the-panc-1-human-pancreatic-cancer-line
#2
Nhan Trung Nguyen, Mai Thanh Thi Nguyen, Hai Xuan Nguyen, Phu Hoang Dang, Dya Fita Dibwe, Hiroyasu Esumi, Suresh Awale
Human pancreatic cancer cell lines have a remarkable tolerance to nutrition starvation, which enables them to survive under a tumor microenvironment. The search for agents that preferentially inhibit the survival of cancer cells under low nutrient conditions represents a novel antiausterity strategy in anticancer drug discovery. In this investigation, a methanol extract of the rhizomes of Boesenbergia pandurata showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient-deprived conditions, with a PC50 value of 6...
January 18, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28099005/complementarity-of-dft-calculations-nmr-anisotropy-and-ecd-for-the-configurational-analysis-of-brevipolides-k-o-from-hyptis-brevipes
#3
G Alejandra Suárez-Ortiz, Carlos M Cerda-García-Rojas, Mabel Fragoso-Serrano, Rogelio Pereda-Miranda
Brevipolides K-O (1-5), five new cytotoxic 6-(6'-cinnamoyloxy-2',5'-epoxy-1'-hydroxyheptyl)-5,6-dihydro-2H-pyran-2-ones (IC50 values against six cancer cell lines, 1.7-10 μM), were purified by recycling HPLC from Hyptis brevipes. The structures, containing a distinctive tetrahydrofuran ring, were established by comprehensive quantum mechanical calculations and experimental spectroscopic analysis of their NMR and ECD data. Detailed analysis of the experimental NMR (1)H-(1)H vicinal coupling constants in comparison with the corresponding DFT-calculated values at the B3LYP/DGDZVP level confirmed the absolute configuration of 3 and revealed its conformational preferences, which were further strengthened by NOESY correlations...
January 18, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28099003/-neocaryachine-an-antiproliferative-pavine-alkaloid-from-cryptocarya-laevigata-induces-dna-double-strand-breaks
#4
Yuki Suzuki, Yohei Saito, Masuo Goto, David J Newman, Barry R O'Keefe, Kuo-Hsiung Lee, Kyoko Nakagawa-Goto
Twelve benzylisoquinoline alkaloids, including pavine and phenanthroindolizidine types, were isolated from a MeOH/CH2Cl2 extract of Cryptocarya laevigata (stem bark) through bioactivity-guided fractionation for antitumor effects. Selected compounds were evaluated for antiproliferative activity against five human tumor cell lines, including a multidrug-resistant subline. Since more common 2,3,8,9-tetrasubstituted pavine alkaloids, such as crychine (3), exhibit very mild or no cytotoxicity, this compound type has not been well investigated for antitumor activity...
January 18, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28098996/ulapualides-c-e-isolated-from-a-hawaiian-hexabranchus-sanguineus-egg-mass
#5
Stephen M Parrish, Wesley Yoshida, Baojun Yang, Philip G Williams
Three new ulapualides (3-5) were isolated from egg masses of the nudibranch Hexabranchus sanguineus. The structures of 3-5 were deduced by analyses of physical and spectroscopic data in comparisons with ulapualides A (1) and B (2). Ulapualide C demonstrated submicromolar cytotoxicity against select NCI cell lines (768-0, DU-145, MDA-MB-231, and A549) with the most potent activity against MDA-MB-231 cells (IC50 0.58 μM). Ulapualides A (1) and B (2) were 2- to 4-fold more potent than 3.
January 18, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28098995/a-chemometrics-approach-to-the-investigation-of-the-intraspecific-variability-of-the-volatile-oil-of-eupatorium-tremulum-from-southern-brazil
#6
Tiago J T de Souza, Sérgio A L Bordignon, Miriam A Apel
Eupatorium tremulum is a South American shrub reported to cause cattle digestive intoxication, of which the volatile oil, mainly composed by bisabolane- and amorphane-type sesquiterpenoids, exhibits high quantitative variability. This report describes the application of chemometric tools for the identification of volatile compounds that characterize phenophasical changes in the plant. Preblooming, blooming, and postblooming specimens were paired-sampled and submitted to hydrodistillation and GC-MS analysis...
January 18, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28093915/oscarellin-an-anthranilic-acid-derivative-from-a-philippine-sponge-oscarella-stillans-as-an-inhibitor-of-inflammatory-cytokines-in-macrophages
#7
Ii-Seul Kwon, Jong Hwan Kwak, Suhkneung Pyo, Hee-Weon Lee, AeRyon Kim, Francis J Schmitz
A new anthranilic acid derivative (1) was isolated from a Philippine sponge, Oscarella stillans (Bergquist and Kelly). The structure of compound 1, named oscarellin, was determined as 2-amino-3-(3'-aminopropoxy)benzoic acid from spectroscopic data and confirmed by synthesis. We examined the immunomodulating effect of compound 1 and its mechanism in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Our data indicated that the expression of tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 were significantly reduced by the pretreatment of 1 (0...
January 17, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28093914/semisynthesis-of-rutamarin-derivatives-and-their-inhibitory-activity-on-epstein-barr-virus-lytic-replication
#8
Yongsheng Lin, Qian Wang, Qiong Gu, Hongao Zhang, Cheng Jiang, Jiayuan Hu, Yan Wang, Yuan Yan, Jun Xu
(+)-Rutamarin inhibits EBV lytic DNA replication with an IC50 of 7.0 μM. (-)-Chalepin, a (-)-rutamarin derivative, was isolated from the whole plant of Ruta graveolens and used as a precursor of (-)-rutamarin. Altogether, 28 (-)-rutamarin derivatives were synthesized starting from (-)-chalepin. Of these, 16 compounds (2a-e, 3b-e, 3g, 4f, 4k, 4m-p) were found to be more potent against EBV lytic DNA replication than (-)-chalepin. Compounds 4m, 4n, and 4p exhibited IC50 values of 1.5, 0.32, and 0.83 μM and showed selectivity index values (SI) of 801, 211, and >120, respectively...
January 17, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28085276/enantiodivergence-in-the-biosynthesis-of-bromotyrosine-alkaloids-from-sponges
#9
Kavita Ragini, Jane Fromont, Andrew M Piggott, Peter Karuso
The isolation of bromotyrosine alkaloids, some of which are enantiomers of previously isolated compounds, has highlighted a possible enantiodivergence in their biosynthesis. Two new (1, 2) and six known bromotyrosine alkaloids (4-9), and the enantiomer (10) of a known compound, have been isolated from a Western Australian marine sponge, Pseudoceratina cf. verrucosa. The compounds inhibited the growth of multidrug-resistant and methicillin-resistant Staphylococcus aureus with comparable activity to vancomycin...
January 13, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28080060/pharmacokinetics-of-the-individual-major-components-of-polymyxin-b-and-colistin-in-rats
#10
Sivashangarie Sivanesan, Kade Roberts, Jiping Wang, Soon-Ee Chea, Philip E Thompson, Jian Li, Roger L Nation, Tony Velkov
The pharmacokinetics of polymyxin B1, polymyxin B2, colistin A, and colistin B were investigated in a rat model following intravenous administration (0.8 mg/kg) of each individual component. Plasma and urine concentrations were determined by LC-MS/MS, and plasma protein binding was measured by ultracentrifugation. Total and unbound pharmacokinetic parameters for each component were calculated using noncompartmental analysis. All of the polymyxin components had a similar clearance, volume of distribution, elimination half-life, and urinary recovery...
January 12, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28079378/dibenzofurans-and-pseudodepsidones-from-the-lichen-stereocaulon-paschale-collected-in-northern-quebec
#11
Claudia Carpentier, Emerson Ferreira Queiroz, Laurence Marcourt, Jean-Luc Wolfender, Jabrane Azelmat, Daniel Grenier, Stéphane Boudreau, Normand Voyer
Chemical investigation of the methanol extract of the lichen Stereocaulon paschale collected in Nunavik, Canada, led to the isolation and identification of two new dibenzofurans (1 and 3) and 11 known lichen metabolites. The structures of the new compounds were established by analysis of 1D and 2D NMR spectroscopic and high-resolution mass spectrometric data. Herein, the first isolation of ascomatic acid dibenzofuran derivatives (1-3) from a whole lichen organism is reported. In addition, some of the isolated metabolites showed antibacterial activity against the oral pathogens Porphyromonas gingivalis and Streptococcus mutans...
January 12, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28079377/review-of-microbiol-ecology-microbiol-ecology-edited-by-l-l-barton-and-d-e-northup-wiley-blackwell-hoboken-nj-usa-2011-440-pp-116-95-hardcover-isbn-978-0-470-04817-7
#12
https://www.readbyqxmd.com/read/28075584/review-of-medicinal-and-aromatic-plants-industrial-profiles-volume-48-sesame-the-genus-sesamum-medicinal-and-aromatic-plants-industrial-profiles-volume-48-sesame-the-genus-sesamum-edited-by-d-bedigian-missouri-botanical-garden-st-louis-missouri-crc-press-taylor
#13
https://www.readbyqxmd.com/read/28075580/antibacterial-and-cytotoxic-phenolic-metabolites-from-the-fruits-of-amorpha-fruticosa
#14
Rini Muharini, Adriana Díaz, Weaam Ebrahim, Attila Mándi, Tibor Kurtán, Nidja Rehberg, Rainer Kalscheuer, Rudolf Hartmann, Raha S Orfali, Wenhan Lin, Zhen Liu, Peter Proksch
Fourteen new natural products, namely, 2-[(Z)-styryl]-5-geranylresorcin-1-carboxylic acid (1), amorfrutin D (2), 4-O-demethylamorfrutin D (3), 8-geranyl-3,5,7-trihydroxyflavanone (4), 8-geranyl-5,7,3'-trihydroxy-4'-methoxyisoflavone (5), 6-geranyl-5,7,3'-trihydroxy-4'-methoxyisoflavone (6), 8-geranyl-7,3'-dihydroxy-4'-methoxyisoflavone (7), 3-O-demethyldalbinol (8), 6a,12a-dehydro-3-O-demethylamorphigenin (9), (6aR,12aR,5'R)-amorphigenin (10), amorphispironones B and C (11 and 12), resokaempferol 3-O-β-d-glucopyranosyl-(1→2)-β-d-glucopyranoside-7-O-α-l-rhamnopyranoside (13), and daidzein 7-O-β-d-glucopyranosyl-(1→2)-β-d-glucopyranoside (14), together with 40 known compounds, were isolated from the fruits of Amorpha fruticosa...
January 11, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28068085/cyclocurcumin-an-antivasoconstrictive-constituent-of-curcuma-longa-turmeric
#15
Keunyoung Kim, Jung-Jun Kim, Yeryeon Jung, Ji-Yoon Noh, Ahmed Shah Syed, Chul Young Kim, Moo-Yeol Lee, Kyung-Min Lim, Ok-Nam Bae, Jin-Ho Chung
Despite the increasing attention on the therapeutic potential of Curcuma longa (turmeric), the biological activities of curcuminoids other than curcumin are not well understood. Here, we investigated antivasoconstrictive activities of C. longa extract and its ingredients using freshly isolated rat aortic rings. C. longa extract significantly suppressed agonist-stimulated vasoconstriction, and cyclocurcumin was found to be the most potent (IC50 against phenylephrine-induced vasoconstriction: 14.9 ± 1.0 μM) among the 10 tested ingredients including four curcuminoids...
January 9, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28067513/evolution-of-quantitative-measures-in-nmr-quantum-mechanical-qhnmr-advances-chemical-standardization-of-a-red-clover-trifolium-pratense-extract
#16
Rasika S Phansalkar, Charlotte Simmler, Jonathan Bisson, Shao-Nong Chen, David C Lankin, James B McAlpine, Matthias Niemitz, Guido F Pauli
Chemical standardization, along with morphological and DNA analysis ensures the authenticity and advances the integrity evaluation of botanical preparations. Achievement of a more comprehensive, metabolomic standardization requires simultaneous quantitation of multiple marker compounds. Employing quantitative (1)H NMR (qHNMR), this study determined the total isoflavone content (TIfCo; 34.5-36.5% w/w) via multimarker standardization and assessed the stability of a 10-year-old isoflavone-enriched red clover extract (RCE)...
January 9, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28060505/%C3%AE-glucosidase-inhibitors-from-malbranchea-flavorosea
#17
Brisa Verastegui-Omaña, Daniela Rebollar-Ramos, Araceli Pérez-Vásquez, Ana Laura Martínez, Abraham Madariaga-Mazón, Laura Flores-Bocanegra, Rachel Mata
From an extract prepared from the grain-based culture of Malbranchea flavorosea two new polyketides, namely, 8-chloroxylarinol A (1) and flavoroseoside (2), along with the known compounds xylarinol A (3), xylarinol B (4), massarigenins B and C (5 and 6), and clavatol (7), were isolated. The structures of 1 and 2 were elucidated using spectroscopic methods and corroborated by single-crystal X-ray diffraction analysis. In the case of compound 2 the absolute configuration at the stereogenic centers was established according to the method of Flack...
January 6, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28058837/talarazines-a-e-noncytotoxic-iron-iii-chelators-from-an-australian-mud-dauber-wasp-associated-fungus-talaromyces-sp-cmb-w045
#18
Pabasara Kalansuriya, Michelle Quezada, Breno P Espósito, Robert J Capon
Chemical analysis of an Australian mud dauber wasp-associated fungus, Talaromyces sp. (CMB-W045), yielded five new coprogen siderophores, talarazines A-E (1-5), together with dimerumic acid (6), desferricoprogen (7), and elutherazine B (8). Structures inclusive of absolute configuration were assigned on the basis of detailed spectroscopic analysis and application of the C3 Marfey's method. We report on the noncytotoxic Fe(III) chelation properties of 1-8 and demonstrate that biosynthesis is regulated by available Fe(III) in culture media...
January 6, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28055219/integrating-molecular-networking-and-biological-assays-to-target-the-isolation-of-a-cytotoxic-cyclic-octapeptide-samoamide-a-from-an-american-samoan-marine-cyanobacterium
#19
C Benjamin Naman, Ramandeep Rattan, Svetlana E Nikoulina, John Lee, Bailey W Miller, Nathan A Moss, Lorene Armstrong, Paul D Boudreau, Hosana M Debonsi, Frederick A Valeriote, Pieter C Dorrestein, William H Gerwick
Integrating LC-MS/MS molecular networking and bioassay-guided fractionation enabled the targeted isolation of a new and bioactive cyclic octapeptide, samoamide A (1), from a sample of cf. Symploca sp. collected in American Samoa. The structure of 1 was established by detailed 1D and 2D NMR experiments, HRESIMS data, and chemical degradation/chromatographic (e.g., Marfey's analysis) studies. Pure compound 1 was shown to have in vitro cytotoxic activity against several human cancer cell lines in both traditional cell culture and zone inhibition bioassays...
January 5, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28055210/bioactive-constituents-from-the-termite-nest-derived-medicinal-fungus-xylaria-nigripes
#20
Jung-Chun Chang, George Hsiao, Ruo-Kai Lin, Yueh-Hsiung Kuo, Yu-Min Ju, Tzong-Huei Lee
Six new eremophilane-type sesquiterpenes, namely, nigriterpenes A-F (1-6), and one new phenolic compound, named 2-hydroxymethyl-3-pentylphenol (7), along with fomannoxin alcohol, 3-butyl-7-hydroxyphthalide, scytalone, and fomannoxin were isolated from the ethyl acetate extracts of the fermented broths of termite nest-derived Xylaria nigripes, which has long been used as a traditional Chinese medicine for treating insomnia and depression. Their structures were elucidated on the basis of spectroscopic data analysis and compared with the literature...
January 5, 2017: Journal of Natural Products
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