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American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions

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https://www.readbyqxmd.com/read/30417231/long-term-effects-of-bosentan-on-cardiovascular-events-in-hispanic-patients-with-intermittent-claudication-four-year-follow-up-of-the-clau-trial-the-clau-randomized-trial-long-term-outcome
#1
Joaquin De Haro, Silvia Bleda, Carmen Gonzalez-Hidalgo, Ignacio Michel, Francisco Acin
INTRODUCTION: The Clinical and Endothelial Function Assessment after Endothelin Receptor Antagonist (CLAU) trial demonstrated the effect of bosentan on the endothelial function, inflammatory status and claudication distance in Hispanic patients with incipient peripheral arterial disease (PAD). Our aim was to assess the protective effect on cardiovascular events of bosentan versus conventional anti-atherosclerosis therapy. METHODS: CLAU included 56 patients with intermittent claudication, randomized 1:1 to receive bosentan for 12 weeks (n = 27) or placebo (n = 29), associating the best medical treatment...
November 12, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/30414088/optimal-medical-therapy-prescribing-patterns-and-disparities-identified-in-patients-with-acute-coronary-syndromes-at-an-academic-medical-center-in-an-area-with-high-coronary-heart-disease-related-mortality
#2
Ashley N Fox, Grant H Skrepnek, Jamie L Miller, Nicholas C Schwier, Toni L Ripley
BACKGROUND: Coronary heart disease (CHD)-related mortality is high in the southern United States. A five-drug pharmacotherapy regimen for acute coronary syndromes (ACS), defined as optimal medical therapy (OMT), can decrease CHD-related mortality. Studies have indicated that OMT is prescribed 50-60% of the time. Assessment of prescribing could provide insight into the potential etiology of disparate mortality. OBJECTIVE: The aim was to evaluate prescribing of OMT at discharge in patients presenting with an ACS event at an academic medical center and identify patients at risk of not receiving OMT...
November 10, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/30406915/assessment-of-non-vitamin-k-oral-anticoagulants-use-in-a-tertiary-care-center-in-the-usa-a-chart-review-of-909-patients
#3
Marwan Sheikh-Taha, Mary E Deeb
BACKGROUND: Non-vitamin K oral anticoagulants (NOACs) have emerged as an attractive alternative to vitamin K antagonists for various thromboembolic indications. However, prescribed NOAC doses are often inconsistent with drug labeling and prescribers might not consider the potential risks associated with concomitant use of other drugs, which can compromise NOACs' safety and effectiveness. METHODS: A retrospective chart review was conducted in a tertiary care center in USA over a 4-month period...
November 8, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/30353444/morphine-and-ticagrelor-interaction-in-primary-percutaneous-coronary-intervention-in-st-segment-elevation-myocardial-infarction-atlantic-morphine
#4
Frédéric Lapostolle, Arnoud W Van't Hof, Christian W Hamm, Olivier Stibbe, Patrick Ecollan, Jean-Philippe Collet, Johanne Silvain, Jens Flensted Lassen, Wim M J M Heutz, Leonardo Bolognese, Warren J Cantor, Angel Cequier, Mohamed Chettibi, Shaun G Goodman, Christopher J Hammett, Kurt Huber, Magnus Janzon, Béla Merkely, Robert F Storey, Jur Ten Berg, Uwe Zeymer, Muriel Licour, Anne Tsatsaris, Gilles Montalescot
BACKGROUND: Morphine adversely impacts the action of oral adenosine diphosphate (ADP)-receptor blockers in ST-segment elevation myocardial infarction (STEMI) patients, and is possibly associated with differing patient characteristics. This retrospective analysis investigated whether interaction between morphine use and pre-percutaneous coronary intervention (pre-PCI) ST-segment elevation resolution in STEMI patients in the ATLANTIC study was associated with differences in patient characteristics and management...
October 23, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/30345485/potential-uses-of-sacubitril-valsartan-need-for-data-on-efficacy-and-safety
#5
Fabien Huet, Mariama Akodad, Eran Kalmanovitch, Jerome Adda, Audrey Agullo, Pascal Batistella, Camille Roubille, François Roubille
Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers have been the cornerstone for the treatment of heart failure (HF) with reduced ejection fraction for decades. According to recent and promising studies, sacubitril/valsartan (SV) might be efficient in alternative indications in the area of HF with preserved left ventricular ejection fraction, chronic kidney disease, and so on. This review briefly summarizes these promising therapeutic options regarding SV and the potential limits and pitfalls for its use in routine practice (due to cognitive uncertainties)...
October 22, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/30255477/statin-use-and-gastrointestinal-hemorrhage-a-large-retrospective-cohort-study
#6
Ashley I Martinez, Patricia R Freeman, Daniela C Moga
BACKGROUND: Nearly 70% of Americans with cardiovascular disease use statins, which have documented bleeding effects independent of their cholesterol-lowering activities. However, the literature is conflicting regarding the association between statin use and gastrointestinal hemorrhage. OBJECTIVES: The aim of this study was to investigate the risk of gastrointestinal hemorrhage in statin users. METHODS: In this retrospective cohort study, data from the Truven Health MarketScan® Research Database (2009-2015) were used to investigate the risk of gastrointestinal hemorrhage amongst statin users aged 30-65 years at the initial prescription claim...
September 26, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/30255476/short-term-effects-of-tolvaptan-in-tricuspid-insufficiency-combined-with-left-heart-valve-replacement-caused-volume-overload-patients-results-of-a-prospective-pilot-study
#7
Fang Yuan, Zhangmin Wu, Li Jiang, Jun Zhou, Lei Xu, Hua Liu, Lan Ma, Zhenzhou Zhai, Junjie Zhang
OBJECTIVES: Our objective was to explore the effects of tolvaptan as a new therapeutic approach in patients with right heart failure with tricuspid insufficiency (TI). METHODS: This prospective, multicenter, non-randomized controlled pilot study enrolled patients (N = 40) with TI from the Shanghai Chest Hospital and Shanghai Tongren Hospital who fulfilled inclusion criteria between March 2015 and June 2016. Participants were assigned to receive either tolvaptan combined with torasemide (n = 20) or torasemide monotherapy (n = 20; control group)...
September 25, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/30229525/a-meta-analysis-of-the-effect-of-pcsk9-monoclonal-antibodies-on-circulating-lipoprotein-a-levels
#8
Ye-Xuan Cao, Hui-Hui Liu, Sha Li, Jian-Jun Li
BACKGROUND: Lipoprotein (a) [Lp(a)] is an atherogenic lipoprotein. While no effective therapy for Lp(a) is currently available, recently, several pooled analyses with small sample sizes have suggested that proprotein convertase subtilisin/kexin type 9 monoclonal antibodies (PCSK9-mAbs) could reduce circulating Lp(a) levels. This meta-analysis was performed to comprehensively investigate the efficacy of PCSK9-mAbs with respect to serum Lp(a) concentrations. METHODS: PubMed, MEDLINE, Embase, ClinicalTrials...
September 19, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/30203330/idarucizumab-for-reversal-of-dabigatran-single-center-real-world-experience
#9
Marwan Sheikh-Taha
BACKGROUND: Idarucizumab is used to reverse the effects of dabigatran. Information on the use of idarucizumab in the clinical setting remains very limited. OBJECTIVE: The objective of this study was to describe clinical experience with idarucizumab in a large medical teaching center in the USA. METHODS: Patients who received idarucizumab to reverse the effects of dabigatran between 1 January 2016 and 30 June 2018 were studied. In patients with major bleeding, the efficacy of idarucizumab was assessed using criteria of the International Society of Thrombosis and Hemostasis Scientific and Standardization Subcommittee...
September 11, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/30182350/efficacy-and-safety-of-the-use-of-non-vitamin-k-antagonist-oral-anticoagulants-in-patients-with-ischemic-heart-disease-a-meta-analysis-of-phase-iii-randomized-trials
#10
REVIEW
Linghua Fu, Wengen Zhu, Lin Huang, Jinzhu Hu, Jianyong Ma, Gregory Y H Lip, Kui Hong
BACKGROUND: There are conflicting published data on non-vitamin K antagonist oral anticoagulants (NOACs), with varying evidence of benefit or harm in acute coronary syndrome (ACS) and non-ACS cohorts. To explore the efficacy and safety of NOAC use in patients with ischemic heart disease (IHD), we conducted a meta-analysis of phase III randomized controlled trials (RCTs). METHODS: We systematically searched the Cochrane Library, PubMed, and Embase databases. A random-effect model was selected to pool the effect measurement estimates (hazard ratios [HRs] and 95% confidence intervals [CIs])...
September 4, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/30155718/the-effect-of-bromodomain-and-extra-terminal-inhibitor-apabetalone-on-attenuated-coronary-atherosclerotic-plaque-insights-from-the-assure-trial
#11
Daisuke Shishikura, Yu Kataoka, Satoshi Honda, Kohei Takata, Susan W Kim, Jordan Andrews, Peter J Psaltis, Michael Sweeney, Ewelina Kulikowski, Jan Johansson, Norman C W Wong, Stephen J Nicholls
BACKGROUND: Apabetalone is a selective bromodomain and extra-terminal (BET) inhibitor which modulates lipid and inflammatory pathways implicated in atherosclerosis. The impact of apabetalone on attenuated coronary atherosclerotic plaque (AP), a measure of vulnerability, is unknown. METHODS: The ApoA-1 Synthesis Stimulation and intravascular Ultrasound for coronary atheroma Regression Evaluation (ASSURE; NCT01067820) study employed serial intravascular ultrasound (IVUS) measures of coronary atheroma in 281 patients treated with apabetalone or placebo for 26 weeks...
August 28, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/30144017/biomarkers-of-thrombosis-in-st-segment-elevation-myocardial-infarction-a-substudy-of-the-atoll-trial-comparing-enoxaparin-versus-unfractionated-heparin
#12
Johanne Silvain, Stephen A O'Connor, Yan Yan, Mathieu Kerneis, Marie Hauguel-Moreau, Michel Zeitouni, Pavel Overtchouk, Annick Ankri, Delphine Brugier, Eric Vicaut, Patrick Ecollan, Sophie Galier, Jean-Philippe Collet, Gilles Montalescot
BACKGROUND: The aim was to compare the peri-procedural biomarkers of coagulation and platelet activation in patients randomly allocated to intravenous enoxaparin or unfractionated heparin (UFH) in the ATOLL randomized trial (NCT00718471). METHODS AND RESULTS: A total of 129 patients (n = 58 enoxaparin and n = 71 UFH) admitted for ST-segment elevation myocardial infarction (STEMI) treated by percutaneous coronary intervention (PCI) were included in this substudy of the ATOLL trial...
August 25, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/30144016/fda-approval-of-angiotensin-ii-for-the-treatment-of-hypotension-in-adults-with-distributive-shock
#13
Fortunato Senatore, Gowraganahalli Jagadeesh, Martin Rose, Venkateswaran C Pillai, Sudharshan Hariharan, Ququan Liu, McDowell Tzu-Yun, Mohan K Sapru, Mary Ross Southworth, Norman Stockbridge
Distributive shock is a subset of shock marked by decreased systemic vascular resistance, organ hypoperfusion and altered oxygen extraction. Despite the use of intravenous fluids and either higher dose of catecholamines or other additional exogenous vasopressors to maintain blood pressure in the target range, the rate of mortality remains higher in patients with septic shock. Therefore, there is clearly an unmet need for additional safe and effective treatments. The use of angiotensin II to raise the mean arterial pressure (MAP) could provide additional therapy and the opportunity to evaluate a catecholamine-sparing effect by decreasing the dose of concomitant catecholamines while maintaining a target MAP...
August 25, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/30144015/healthcare-utilization-and-expenditures-in-working-age-adults-with-atrial-fibrillation-the-effect-of-switching-from-warfarin-to-non-vitamin-k-oral-anticoagulants
#14
Xue Feng, Usha Sambamoorthi, Kim Innes, Traci LeMasters, Gregory Castelli, Nilanjana Dwibedi, Xi Tan
OBJECTIVE: Our objective was to evaluate the association between switching from warfarin to non-vitamin K oral anticoagulants (NOACs) and potential drug-drug interactions (DDIs), healthcare utilization, and expenditures in working-age adults with atrial fibrillation (AF). METHODS: We conducted a retrospective cohort study using data from 2010 to 2015 for patients who switched from warfarin to NOACs (switchers) and those who continued to receive warfarin (non-switchers)...
August 25, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/30132141/early-and-late-stent-thrombosis-in-patients-with-versus-without-diabetes-mellitus-following-percutaneous-coronary-intervention-with-drug-eluting-stents-a-systematic-review-and-meta-analysis
#15
Jun Yuan, Guang Ma Xu
BACKGROUND: Nowadays, drug-eluting stents (DES) are most commonly used compared with bare metal stents (BMS) since the former are associated with significantly lower rates of revascularization following percutaneous coronary intervention (PCI). However, unpredictable in-stent thrombosis is a major concern with DES, especially in patients with diabetes mellitus. OBJECTIVE: In this analysis, we aimed to systematically compare early and late stent thrombosis in patients with versus without diabetes mellitus following PCI with DES...
August 22, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/30132140/patients-priorities-for-oral-anticoagulation-therapy-in-non-valvular-atrial-fibrillation-a-multi-criteria-decision-analysis
#16
Marieke G M Weernink, Melissa C W Vaanholt, Catharina G M Groothuis-Oudshoorn, Clemens von Birgelen, Maarten J IJzerman, Janine A van Til
INTRODUCTION: Effectiveness of oral anticoagulants (OACs) is critically dependent on patients' adherence to intake regimens. We studied the relative impact of attributes related to effectiveness, safety, convenience, and costs on the value of OAC therapy from the perspective of patients with non-valvular atrial fibrillation. METHODS: Four attributes were identified by literature review and expert interviews: effectiveness (risk of ischemic stroke), safety (risk of major bleeding, minor bleeding, gastrointestinal complaints), convenience (intake frequency, diet restrictions, international normalized ratio [INR] blood monitoring, pill type/intake instructions), and out-of-pocket costs...
August 22, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29971596/association-between-high-dose-spironolactone-and-decongestion-in-patients-with-acute-heart-failure-an-observational-retrospective-study
#17
Chris J Kapelios, Maria Bonou, Paraskevi Vogiatzi, George Tzanis, Polyxeni Mantzouratou, Lars H Lund, John Barbetseas
BACKGROUND: Acute congestive heart failure (ACHF) is a state of severe, secondary hyperaldosteronism. Relief of congestion has prognostic implications. Our aim was to assess associations between high-dose spironolactone and (1) decongestion and (2) safety in patients with ACHF. METHODS: The charts of 20 patients who were hospitalized with ACHF and received high doses of spironolactone (75-300 mg daily, group A) on top of standard of care (SOC) treatment were retrospectively studied and compared with the ones of 20 matched patients who received SOC treatment alone (group B)...
October 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29948822/efficacy-and-safety-of-intravenous-tenecteplase-bolus-in-acute-ischemic-stroke-results-of-two-open-label-multicenter-trials
#18
Tirppur C R Ramakrishnan, Somasundaram Kumaravelu, Sunil K Narayan, Sai S Buddha, Ch Murali, Palakkapparampil H A Majeed, Salvadeeswaran Meenakshi-Sundaram, Rustom S Wadia, Vikram Sharma, Indraneel Basu, Pamidimukkala Vijaya, Kizhakkaniyakath A Salam, Shahid Barmare, Zubin Vaid, K K Nirmal Raj, Pandurang R Wattamwar, Konbappan Asokan, Vijaykumar Dhonge, Shankara Nellikunja, Deepak Namjoshi, Rangasetty Srinivasa, Deepak S Laddhad, Shirish D Deshpande, Balakrishnan Raghunath, Jayantee Kalita, Mritunjai Kumar, Usha K Misra, Methil Pradeep
BACKGROUND: Tenecteplase (TNK-tPA) is a promising third-generation plasminogen activator, because of its greater fibrin specificity and longer half-life than alteplase. There is a paucity of studies on intravenous thrombolysis using TNK-tPA in developing countries. The present study has been undertaken to compare the efficacy and safety of TNK-tPA with alteplase. METHODS: Two studies were conducted. Study I was an open-label, randomized study in which two doses of TNK-tPA (0...
October 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29845546/treatment-with-mannitol-is-associated-with-increased-risk-for-in-hospital-mortality-in-patients-with-acute-ischemic-stroke-and-cerebral-edema
#19
Marianthi Papagianni, Konstantinos Tziomalos, Stavroula Kostaki, Stella-Maria Angelopoulou, Konstantinos Christou, Stella D Bouziana, Maria Vergou, Triantafyllos Didangelos, Christos Savopoulos, Apostolos I Hatzitolios
BACKGROUND: Current guidelines state that osmotic therapy is reasonable in patients with clinical deterioration from cerebral infarction-related cerebral edema. However, there are limited data on the safety and efficacy of this therapy. We aimed to evaluate the effect of mannitol on the outcome of ischemic stroke-related cerebral edema. METHODS AND RESULTS: We prospectively studied 922 consecutive patients admitted with acute ischemic stroke. Patients who showed space-occupying brain edema with tissue shifts compressing the midline structures received mannitol...
October 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29633091/vitamins-for-prevention-of-contrast-induced-acute-kidney-injury-a-systematic-review-and-trial-sequential-analysis
#20
REVIEW
Yongxing Xu, Xinming Zheng, Boran Liang, Jianjun Gao, Zhaoyan Gu
BACKGROUND: To date, universally accepted preventive measures for contrast-induced acute kidney injury (CI-AKI) do not exist, and they warrant further research. OBJECTIVE: The purpose of this study was to evaluate the efficacy of vitamins, including vitamin C and E, for prevention of CI-AKI. METHODS: We electronically searched the MEDLINE, EMBASE, and Cochrane databases. The outcome of interest was the incidence of CI-AKI. RESULTS: A total of 19 studies were included in this meta-analysis...
October 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
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