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JAMA: the Journal of the American Medical Association

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https://www.readbyqxmd.com/read/27923072/revised-cioms-international-ethical-guidelines-for-health-related-research-involving-humans
#1
Johannes J M van Delden, Rieke van der Graaf
No abstract text is available yet for this article.
December 6, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27918795/scientific-evidence-and-financial-obligations-to-ensure-access-to-biosimilars-for-cancer-treatment
#2
Howard Bauchner, Phil B Fontanarosa, Robert M Golub
No abstract text is available yet for this article.
December 1, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27918782/biosimilar-therapy-for-erbb2-her2-positive-breast-cancer-close-enough
#3
Harold J Burstein, Deborah Schrag
No abstract text is available yet for this article.
December 1, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27918780/effect-of-a-proposed-trastuzumab-biosimilar-compared-with-trastuzumab-on-overall-response-rate-in-patients-with-erbb2-her2-positive-metastatic-breast-cancer-a-randomized-clinical-trial
#4
Hope S Rugo, Abhijit Barve, Cornelius F Waller, Miguel Hernandez-Bronchud, Jay Herson, Jinyu Yuan, Rajiv Sharma, Mark Baczkowski, Mudgal Kothekar, Subramanian Loganathan, Alexey Manikhas, Igor Bondarenko, Guzel Mukhametshina, Gia Nemsadze, Joseph D Parra, Maria Luisa T Abesamis-Tiambeng, Kakhaber Baramidze, Charuwan Akewanlop, Ihor Vynnychenko, Virote Sriuranpong, Gopichand Mamillapalli, Sirshendu Ray, Eduardo P Yanez Ruiz, Eduardo Pennella
Importance: Treatment with the anti-ERBB2 humanized monoclonal antibody trastuzumab and chemotherapy significantly improves outcome in patients with ERBB2 (HER2)-positive metastatic breast cancer; a clinically effective biosimilar may help increase access to this therapy. Objective: To compare the overall response rate and assess the safety of a proposed trastuzumab biosimilar plus a taxane or trastuzumab plus a taxane in patients without prior treatment for ERBB2-positive metastatic breast cancer...
December 1, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27898977/artificial-intelligence-with-deep-learning-technology-looks-into-diabetic-retinopathy-screening
#5
Tien Yin Wong, Neil M Bressler
No abstract text is available yet for this article.
November 29, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27898976/development-and-validation-of-a-deep-learning-algorithm-for-detection-of-diabetic-retinopathy-in-retinal-fundus-photographs
#6
Varun Gulshan, Lily Peng, Marc Coram, Martin C Stumpe, Derek Wu, Arunachalam Narayanaswamy, Subhashini Venugopalan, Kasumi Widner, Tom Madams, Jorge Cuadros, Ramasamy Kim, Rajiv Raman, Philip C Nelson, Jessica L Mega, Dale R Webster
Importance: Deep learning is a family of computational methods that allow an algorithm to program itself by learning from a large set of examples that demonstrate the desired behavior, removing the need to specify rules explicitly. Application of these methods to medical imaging requires further assessment and validation. Objective: To apply deep learning to create an algorithm for automated detection of diabetic retinopathy and diabetic macular edema in retinal fundus photographs...
November 29, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27898975/adapting-to-artificial-intelligence-radiologists-and-pathologists-as-information-specialists
#7
Saurabh Jha, Eric J Topol
No abstract text is available yet for this article.
November 29, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27898974/translating-artificial-intelligence-into-clinical-care
#8
Andrew L Beam, Isaac S Kohane
No abstract text is available yet for this article.
November 29, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27893882/the-future-of-the-aca-and-health-care-policy-in-the-united-states
#9
Gail R Wilensky
No abstract text is available yet for this article.
November 28, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27893878/the-affordable-care-act-moving-forward-in-the-coming-years
#10
Lawrence O Gostin, David A Hyman, Peter D Jacobson
No abstract text is available yet for this article.
November 28, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27893074/the-nurses-health-study-takes-fresh-aim-at-breast-cancer-as-it-heads-into-decade-five
#11
Jennifer Abbasi
No abstract text is available yet for this article.
November 23, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27893068/immunogenicity-of-the-9-valent-hpv-vaccine-using-2-dose-regimens-in-girls-and-boys-vs-a-3-dose-regimen-in-women
#12
Ole-Erik Iversen, Maria Jose Miranda, Angels Ulied, Terje Soerdal, Erica Lazarus, Kulkanya Chokephaibulkit, Stan L Block, Ales Skrivanek, Abdul Ghani Nur Azurah, Siew Moy Fong, Vladimir Dvorak, Kyung-Hyo Kim, Ramon M Cestero, Matitiahu Berkovitch, Mehmet Ceyhan, Misoo C Ellison, Michael A Ritter, Shuai S Yuan, Mark J DiNubile, Alfred J Saah, Alain Luxembourg
Importance: Human papillomavirus (HPV) infections cause anogenital cancers and warts. The 9-valent HPV vaccine provides protection against 7 high-risk types of HPV responsible for 90% of cervical cancers and 2 other HPV types accounting for 90% of genital warts. Objective: To determine whether HPV type-specific antibody responses would be noninferior among girls and boys aged 9 to 14 years after receiving 2 doses of the 9-valent HPV vaccine compared with adolescent girls and young women aged 16 to 26 years receiving 3 doses...
November 21, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27893046/two-vs-three-doses-of-human-papillomavirus-vaccine-new-policy-for-the-second-decade-of-the-vaccination-program
#13
Lauri E Markowitz, Elissa Meites, Elizabeth R Unger
No abstract text is available yet for this article.
November 21, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27854372/surgeon-general-s-report-on-alcohol-drugs-and-health
#14
Vivek H Murthy
No abstract text is available yet for this article.
November 17, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27846344/effect-of-evolocumab-on-progression-of-coronary-disease-in-statin-treated-patients-the-glagov-randomized-clinical-trial
#15
Stephen J Nicholls, Rishi Puri, Todd Anderson, Christie M Ballantyne, Leslie Cho, John J P Kastelein, Wolfgang Koenig, Ransi Somaratne, Helina Kassahun, Jingyuan Yang, Scott M Wasserman, Robert Scott, Imre Ungi, Jakub Podolec, Antonius Oude Ophuis, Jan H Cornel, Marilyn Borgman, Danielle M Brennan, Steven E Nissen
Importance: Reducing levels of low-density lipoprotein cholesterol (LDL-C) with intensive statin therapy reduces progression of coronary atherosclerosis in proportion to achieved LDL-C levels. Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors produce incremental LDL-C lowering in statin-treated patients; however, the effects of these drugs on coronary atherosclerosis have not been evaluated. Objective: To determine the effects of PCSK9 inhibition with evolocumab on progression of coronary atherosclerosis in statin-treated patients...
November 15, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27837602/effect-of-a-multicomponent-behavioral-intervention-in-adults-impaired-by-psychological-distress-in-a-conflict-affected-area-of-pakistan-a-randomized-clinical-trial
#16
Atif Rahman, Syed Usman Hamdani, Naila Riaz Awan, Richard A Bryant, Katie S Dawson, Muhammad Firaz Khan, Mian Mukhtar-Ul-Haq Azeemi, Parveen Akhtar, Huma Nazir, Anna Chiumento, Marit Sijbrandij, Duolao Wang, Saeed Farooq, Mark van Ommeren
Importance: The mental health consequences of conflict and violence are wide-ranging and pervasive. Scalable interventions to address a range of mental health problems are needed. Objective: To test the effectiveness of a multicomponent behavioral intervention delivered by lay health workers to adults with psychological distress in primary care settings. Design, Setting, and Participants: A randomized clinical trial was conducted from November 1, 2014, through January 28, 2016, in 3 primary care centers in Peshawar, Pakistan, that included 346 adult primary care attendees with high levels of both psychological distress and functional impairment according to the 12-item General Health Questionnaire and the World Health Organization Disability Assessment Schedule 2...
November 12, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27835709/trend-in-ventilator-associated-pneumonia-rates-between-2005-and-2013
#17
Mark L Metersky, Yun Wang, Michael Klompas, Sheila Eckenrode, Anila Bakullari, Noel Eldridge
No abstract text is available yet for this article.
November 11, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27829076/do-apollo-astronaut-deaths-shine-a-light-on-deep-space-radiation-and-cardiovascular-disease
#18
Jennifer Abbasi
No abstract text is available yet for this article.
November 9, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27820637/knowing-when-and-how-to-use-medical-products-a-shared-responsibility-for-the-fda-and-cms
#19
Robert M Califf, Rachel E Sherman, Andrew Slavitt
No abstract text is available yet for this article.
November 7, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27812693/increase-in-us-suicide-rates-and-the-critical-decline-in-psychiatric-beds
#20
Tarun Bastiampillai, Steven S Sharfstein, Stephen Allison
No abstract text is available yet for this article.
November 3, 2016: JAMA: the Journal of the American Medical Association
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