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Circulation

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https://www.readbyqxmd.com/read/30372145/letter-by-rodr%C3%A3-guez-et-al-regarding-article-cardiac-arrest-with-st-segment-elevation-in-v1-and-v2-differential-diagnosis
#1
LETTER
Alberto Rodríguez, Andrés Carrillo, Miquel Fiol
No abstract text is available yet for this article.
October 30, 2018: Circulation
https://www.readbyqxmd.com/read/30372144/thrombogenic-and-arrhythmogenic-roles-of-the-left-atrial-appendage-in-atrial-fibrillation
#2
Luigi Di Biase, Andrea Natale, Jorge Romero
Understanding the anatomy, physiology, and arrhythmogenic and thrombogenic roles of the left atrial appendage (LAA) has become very important. The potential deleterious effects of this chamber in patients with atrial fibrillation have led to the development of specific treatments for this structure. It has been established that the LAA is the area where the vast majority of thrombi in nonvalvular atrial fibrillation are formed and that some LAA morphologies may actually facilitate thrombi formation and risk stratification for thromboembolic events in patients with low CHA2 DS2 -VASc scores...
October 30, 2018: Circulation
https://www.readbyqxmd.com/read/30372143/letter-by-madias-regarding-article-cardiac-arrest-with-st-segment-elevation-in-v1-and-v2-differential-diagnosis
#3
LETTER
John E Madias
No abstract text is available yet for this article.
October 30, 2018: Circulation
https://www.readbyqxmd.com/read/30372142/response-by-arroyo-rivera-et-al-to-letters-regarding-article-cardiac-arrest-with-st-segment-elevation-in-v1-and-v2-differential-diagnosis
#4
LETTER
Belén Arroyo Rivera, Pepa Sánchez-Borque, Miguel Orejas, Álvaro Aceña, Jose Tuñón
No abstract text is available yet for this article.
October 30, 2018: Circulation
https://www.readbyqxmd.com/read/30372141/brain-derived-neurotrophic-factor-improves-limited-exercise-capacity-in-mice-with-heart-failure
#5
LETTER
Junichi Matsumoto, Shingo Takada, Shintaro Kinugawa, Takaaki Furihata, Hideo Nambu, Naoya Kakutani, Masaya Tsuda, Arata Fukushima, Takashi Yokota, Shinya Tanaka, Hidehisa Takahashi, Masashi Watanabe, Shigetsugu Hatakeyama, Masaki Matsumoto, Keiichi I Nakayama, Yutaro Otsuka, Hisataka Sabe, Hiroyuki Tsutsui, Toshihisa Anzai
No abstract text is available yet for this article.
October 30, 2018: Circulation
https://www.readbyqxmd.com/read/30372140/evaluation-of-a-novel-rule-out-myocardial-infarction-protocol-incorporating-high-sensitivity-troponin-t-in-a-us-hospital
#6
LETTER
Rebecca Vigen, Patricia Kutscher, Fernabelle Fernandez, Amy Yu, Bryan Bertulfo, Ibrahim A Hashim, Kyle Molberg, Deborah B Diercks, Jeffery C Metzger, Jose Soto, Dergham Alzubaidy, Lorie Thibodeaux, Jose A Joglar, James A de Lemos, Sandeep R Das
No abstract text is available yet for this article.
October 30, 2018: Circulation
https://www.readbyqxmd.com/read/30372139/not-too-little-and-not-too-late
#7
EDITORIAL
João L Cavalcante, Paul Sorajja
No abstract text is available yet for this article.
October 30, 2018: Circulation
https://www.readbyqxmd.com/read/30372138/inhibit-a-phosphodiesterase-to-treat-heart-failure
#8
EDITORIAL
Jérôme Leroy, Rodolphe Fischmeister
No abstract text is available yet for this article.
October 30, 2018: Circulation
https://www.readbyqxmd.com/read/30372137/highlights-from-the-circulation-family-of-journals
#9
(no author information available yet)
No abstract text is available yet for this article.
October 30, 2018: Circulation
https://www.readbyqxmd.com/read/30372136/simultaneous-recording-of-the-p-wave-during-atrial-fibrillation
#10
Atsuhiko Yagishita, Masahiko Goya, Kenzo Hirao
No abstract text is available yet for this article.
October 30, 2018: Circulation
https://www.readbyqxmd.com/read/30372135/letter-by-gottschalk-et-al-regarding-article-cardiac-arrest-with-st-segment-elevation-in-v1-and-v2-differential-diagnosis
#11
LETTER
Byron H Gottschalk, Javier Garcia-Niebla, Adrian Baranchuk
No abstract text is available yet for this article.
October 30, 2018: Circulation
https://www.readbyqxmd.com/read/30372134/management-of-pharyngitis
#12
Jonathan Berkley
No abstract text is available yet for this article.
October 30, 2018: Circulation
https://www.readbyqxmd.com/read/30372133/heart-spleen-brain
#13
Daniela Carnevale, Giuseppe Lembo
No abstract text is available yet for this article.
October 30, 2018: Circulation
https://www.readbyqxmd.com/read/30030415/acute-enhancement-of-cardiac-function-by-phosphodiesterase-type-1-inhibition
#14
Toru Hashimoto, Grace E Kim, Richard S Tunin, Tolulope Adesiyun, Steven Hsu, Ryo Nakagawa, Guangshuo Zhu, Jennifer J O'Brien, Joseph P Hendrick, Robert E Davis, Wei Yao, David Beard, Helen R Hoxie, Lawrence P Wennogle, Dong I Lee, David A Kass
BACKGROUND: Phosphodiesterase type-1 (PDE1) hydrolyzes cAMP and cGMP and is constitutively expressed in the heart, although cardiac effects from its acute inhibition in vivo are largely unknown. Existing data are limited to rodents expressing mostly the cGMP-favoring PDE1A isoform. Human heart predominantly expresses PDE1C with balanced selectivity for cAMP and cGMP. Here, we determined the acute effects of PDE1 inhibition in PDE1C-expressing mammals, dogs, and rabbits, in normal and failing hearts, and explored its regulatory pathways...
October 30, 2018: Circulation
https://www.readbyqxmd.com/read/30018169/higher-aortic-stiffness-is-related-to-lower-cerebral-blood-flow-and-preserved-cerebrovascular-reactivity-in-older-adults
#15
Angela L Jefferson, Francis E Cambronero, Dandan Liu, Elizabeth E Moore, Jacquelyn E Neal, James G Terry, Sangeeta Nair, Kimberly R Pechman, Swati Rane, L Taylor Davis, Katherine A Gifford, Timothy J Hohman, Susan P Bell, Thomas J Wang, Joshua A Beckman, John Jeffrey Carr
BACKGROUND: Mechanisms underlying the association between age-related arterial stiffening and poor brain health remain elusive. Cerebral blood flow (CBF) homeostasis may be implicated. This study evaluates how aortic stiffening relates to resting CBF and cerebrovascular reactivity (CVR) in older adults. METHODS: Vanderbilt Memory & Aging Project participants free of clinical dementia, stroke, and heart failure were studied, including older adults with normal cognition (n=155; age, 72±7 years; 59% male) or mild cognitive impairment (n=115; age, 73±7 years; 57% male)...
October 30, 2018: Circulation
https://www.readbyqxmd.com/read/30002099/myocardial-scar-and-mortality-in-severe-aortic-stenosis
#16
Tarique A Musa, Thomas A Treibel, Vassiliou S Vassiliou, Gabriella Captur, Anvesha Singh, Calvin Chin, Laura E Dobson, Silvia Pica, Margaret Loudon, Tamir Malley, Marzia Rigolli, James R J Foley, Petra Bijsterveld, Graham R Law, Marc R Dweck, Saul G Myerson, Gerry P McCann, Sanjay K Prasad, James C Moon, John P Greenwood
BACKGROUND: Aortic valve replacement (AVR) for aortic stenosis is timed primarily on the development of symptoms, but late surgery can result in irreversible myocardial dysfunction and additional risk. The aim of this study was to determine whether the presence of focal myocardial scar preoperatively was associated with long-term mortality. METHODS: In a longitudinal observational outcome study, survival analysis was performed in patients with severe aortic stenosis listed for valve intervention at 6 UK cardiothoracic centers...
October 30, 2018: Circulation
https://www.readbyqxmd.com/read/29967197/linking-endogenous-factor-xa-activity-a-biologically-relevant-pharmacodynamic-marker-to-edoxaban-plasma-concentrations-and-clinical-outcomes-in-the-engage-af-timi-48-trial
#17
Ophelia Q P Yin, Elliott M Antman, Eugene Braunwald, Michele F Mercuri, Raymond Miller, David Morrow, Christian T Ruff, Kenneth Truitt, Jeffrey I Weitz, Robert P Giugliano
BACKGROUND: We previously reported exogenous antifactor Xa (FXa) activity as a pharmacokinetic surrogate marker for edoxaban plasma concentrations. Inhibition of endogenous FXa activity is a more biologically relevant pharmacodynamic measure of edoxaban activity. Here we describe the value of endogenous FXa activity as a pharmacodynamic marker linking edoxaban concentrations and clinical outcomes in the ENGAGE AF-TIMI 48 trial (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction Study 48)...
October 30, 2018: Circulation
https://www.readbyqxmd.com/read/29967195/il-interleukin-10-stat3-galectin-3-axis-is-essential-for-osteopontin-producing-reparative-macrophage-polarization-after-myocardial-infarction
#18
Kohsuke Shirakawa, Jin Endo, Masaharu Kataoka, Yoshinori Katsumata, Naohiro Yoshida, Tsunehisa Yamamoto, Sarasa Isobe, Hidenori Moriyama, Shinichi Goto, Hiroki Kitakata, Takahiro Hiraide, Keiichi Fukuda, Motoaki Sano
BACKGROUND: Both osteopontin (OPN) and galectin-3 have been implicated in phagocytic clearance of dead cells and reparative fibrosis during wound healing. CD206+ macrophages are involved in tissue repair through phagocytosis and fibrosis after myocardial infarction (MI). However, the relationship among OPN, galectin-3, and macrophage polarization in the context of MI remains unclear. METHODS: The time course of Spp1 (encoding OPN) expression in the heart after MI showed a strong activation of Spp1 on day 3 after MI...
October 30, 2018: Circulation
https://www.readbyqxmd.com/read/29871977/multiprotein-complex-with-trpc-transient-receptor-potential-canonical-channel-pde1c-phosphodiesterase-1c-and-a2r-adenosine-a2-receptor-plays-a-critical-role-in-regulating-cardiomyocyte-camp-and-survival
#19
Yishuai Zhang, Walter Knight, Si Chen, Amy Mohan, Chen Yan
BACKGROUND: cAMP plays a critical role in regulating cardiomyocyte survival. Various cAMP signaling pathways behave distinctly or in opposition. We have previously reported that activation of cAMP hydrolysis by cyclic nucleotide phosphodiesterase 1C (PDE1C) promotes cardiomyocytes death/apoptosis, yet the underlying molecular mechanism remains unknown. In this study, we aimed to identify the specific cAMP signaling pathway modulated by PDE1C and determine the mechanism by which Ca2+ /calmodulin-stimulated PDE1C is activated...
October 30, 2018: Circulation
https://www.readbyqxmd.com/read/29807933/healthcare-resource-use-and-cost-implications-in-the-momentum-3-long-term-outcome-study
#20
Mandeep R Mehra, Christopher Salerno, Joseph C Cleveland, Sean Pinney, Melana Yuzefpolskaya, Carmelo A Milano, Akinobu Itoh, Daniel J Goldstein, Nir Uriel, Sanjeev Gulati, Francis D Pagani, Ranjit John, Robert Adamson, Roberta Bogaev, Vinay Thohan, Joyce Chuang, Poornima Sood, Scott Goates, Scott C Silvestry
BACKGROUND: The MOMENTUM 3 trial compares the centrifugal HeartMate 3 (HM3) with the axial HeartMate II (HMII) continuous-flow left ventricular assist system in patients with advanced heart failure, irrespective of the intended goal of therapy. The trial's 2-year clinical outcome (n=366) demonstrated superiority of the HM3 for the primary end point (survival free of a disabling stroke or reoperation to replace or remove a malfunctioning pump). This analysis evaluates health resource use and cost implications of the observed differences between the 2 devices while patients were enrolled in the trial...
October 30, 2018: Circulation
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