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https://www.readbyqxmd.com/read/29961641/the-how-a-message-for-the-un-high-level-meeting-on-ncds
#1
LETTER
(no author information available yet)
No abstract text is available yet for this article.
June 28, 2018: Lancet
https://www.readbyqxmd.com/read/29961640/efficacy-and-safety-of-continuing-versus-withdrawing-adalimumab-therapy-in-maintaining-remission-in-patients-with-non-radiographic-axial-spondyloarthritis-ability-3-a-multicentre-randomised-double-blind-study
#2
Robert Landewé, Joachim Sieper, Philip Mease, Robert D Inman, Robert G Lambert, Atul Deodhar, Helena Marzo-Ortega, Marina Magrey, Uta Kiltz, Xin Wang, Mei Li, Sheng Zhong, Nael M Mostafa, Apinya Lertratanakul, Aileen L Pangan, Jaclyn K Anderson
BACKGROUND: Success of treatment withdrawal in patients with non-radiographic axial spondyloarthritis who are in remission remains unknown. The ABILITY-3 study explored the ability to withdraw adalimumab treatment in patients with non-radiographic axial spondyloarthritis who achieved sustained clinical remission after open-label treatment with adalimumab. METHODS: ABILITY-3 was a multicentre, two-period study done in 107 sites in 20 countries. We enrolled adult patients (≥18 years) diagnosed with non-radiographic axial spondyloarthritis, fulfilling Assessment of SpondyloArthritis international Society classification criteria but not the modified New York radiologic criterion, who had objective evidence of active inflammation, active disease, and inadequate response to at least two non-steroidal anti-inflammatory drugs...
June 28, 2018: Lancet
https://www.readbyqxmd.com/read/29961639/on-the-road-to-universal-health-care-in-indonesia-1990-2016-a-systematic-analysis-for-the-global-burden-of-disease-study-2016
#3
Nafsiah Mboi, Indra Murty Surbakti, Indang Trihandini, Iqbal Elyazar, Karen Houston Smith, Pungkas Bahjuri Ali, Soewarta Kosen, Kristin Flemons, Sarah E Ray, Jackie Cao, Scott D Glenn, Molly K Miller-Petrie, Meghan D Mooney, Jeffrey L Ried, Dina Nur Anggraini Ningrum, Fachmi Idris, Kemal N Siregar, Pandu Harimurti, Robert S Bernstein, Tikki Pangestu, Yuwono Sidharta, Mohsen Naghavi, Christopher J L Murray, Simon I Hay
BACKGROUND: As Indonesia moves to provide health coverage for all citizens, understanding patterns of morbidity and mortality is important to allocate resources and address inequality. The Global Burden of Disease 2016 study (GBD 2016) estimates sources of early death and disability, which can inform policies to improve health care. METHODS: We used GBD 2016 results for cause-specific deaths, years of life lost, years lived with disability, disability-adjusted life-years (DALYs), life expectancy at birth, healthy life expectancy, and risk factors for 333 causes in Indonesia and in seven comparator countries...
June 28, 2018: Lancet
https://www.readbyqxmd.com/read/29961638/management-of-multimorbidity-using-a-patient-centred-care-model-a-pragmatic-cluster-randomised-trial-of-the-3d-approach
#4
Chris Salisbury, Mei-See Man, Peter Bower, Bruce Guthrie, Katherine Chaplin, Daisy M Gaunt, Sara Brookes, Bridie Fitzpatrick, Caroline Gardner, Sandra Hollinghurst, Victoria Lee, John McLeod, Cindy Mann, Keith R Moffat, Stewart W Mercer
BACKGROUND: The management of people with multiple chronic conditions challenges health-care systems designed around single conditions. There is international consensus that care for multimorbidity should be patient-centred, focus on quality of life, and promote self-management towards agreed goals. However, there is little evidence about the effectiveness of this approach. Our hypothesis was that the patient-centred, so-called 3D approach (based on dimensions of health, depression, and drugs) for patients with multimorbidity would improve their health-related quality of life, which is the ultimate aim of the 3D intervention...
June 28, 2018: Lancet
https://www.readbyqxmd.com/read/29961637/discontinuing-tumour-necrosis-factor-inhibitors-in-non-radiographic-axial-spondyloarthritis
#5
Jürgen Braun
No abstract text is available yet for this article.
June 28, 2018: Lancet
https://www.readbyqxmd.com/read/29961636/reducing-ncds-globally-the-under-recognised-role-of-environmental-risk-factors
#6
LETTER
Rajiv Chowdhury, Rian Lawrence, Kim van Daalen, Sarah Hawkes, Joerg Feldmann
No abstract text is available yet for this article.
June 28, 2018: Lancet
https://www.readbyqxmd.com/read/29961635/patient-centred-care-for-multimorbidity-an-end-in-itself
#7
Christopher Dowrick
No abstract text is available yet for this article.
June 28, 2018: Lancet
https://www.readbyqxmd.com/read/29954587/preventing-rural-to-urban-spread-of-ebola-lessons-from-liberia
#8
LETTER
Mosoka P Fallah, Laura A Skrip, Jonathan Enders
No abstract text is available yet for this article.
June 25, 2018: Lancet
https://www.readbyqxmd.com/read/29945728/agonism-of-receptors-in-the-gut-pancreas-axis-in-type-2-diabetes-are-two-better-than-one
#9
Christopher K Rayner, Michael Horowitz
No abstract text is available yet for this article.
June 22, 2018: Lancet
https://www.readbyqxmd.com/read/29945727/medi0382-a-glp-1-and-glucagon-receptor-dual-agonist-in-obese-or-overweight-patients-with-type-2-diabetes-a-randomised-controlled-double-blind-ascending-dose-and-phase-2a-study
#10
Philip Ambery, Victoria E Parker, Michael Stumvoll, Maximilian G Posch, Tim Heise, Leona Plum-Moerschel, Lan-Feng Tsai, Darren Robertson, Meena Jain, Marcella Petrone, Cristina Rondinone, Boaz Hirshberg, Lutz Jermutus
BACKGROUND: Weight loss is often key in the management of obese or overweight patients with type 2 diabetes, yet few treatments for diabetes achieve clinically meaningful weight loss. We aimed to assess the efficacy, tolerability, and safety of treatment with MEDI0382, a balanced glucagon-like peptide-1 and glucagon receptor dual agonist developed to provide glycaemic control and weight loss, in patients with type 2 diabetes. METHODS: This randomised, placebo-controlled, double-blind, combined multiple-ascending dose (MAD) and phase 2a study was done at 11 study sites (hospitals and contract research organisations) in Germany...
June 22, 2018: Lancet
https://www.readbyqxmd.com/read/29937195/personalised-perioperative-care-by-e-health-after-intermediate-grade-abdominal-surgery-a-multicentre-single-blind-randomised-placebo-controlled-trial
#11
Eva van der Meij, Johannes R Anema, Wouter K G Leclercq, Marlies Y Bongers, Esther C J Consten, Steven E Schraffordt Koops, Peter M van de Ven, Caroline B Terwee, Johanna M van Dongen, Frederieke G Schaafsma, Wilhelmus J H J Meijerink, Hendrik J Bonjer, Judith A F Huirne
BACKGROUND: Instructing and guiding patients after surgery is essential for successful recovery. However, the time that health-care professionals can spend with their patients postoperatively has been reduced because of efficiency-driven, shortened hospital stays. We evaluated the effect of a personalised e-health-care programme on return to normal activities after surgery. METHODS: A multicentre, single-blind, randomised controlled trial was done at seven teaching hospitals in the Netherlands...
June 21, 2018: Lancet
https://www.readbyqxmd.com/read/29937194/personalised-recovery-after-general-and-gynaecologic-surgery
#12
Shuyan Wei, Lillian S Kao
No abstract text is available yet for this article.
June 21, 2018: Lancet
https://www.readbyqxmd.com/read/29937193/police-killings-and-their-spillover-effects-on-the-mental-health-of-black-americans-a-population-based-quasi-experimental-study
#13
Jacob Bor, Atheendar S Venkataramani, David R Williams, Alexander C Tsai
BACKGROUND: Police kill more than 300 black Americans-at least a quarter of them unarmed-each year in the USA. These events might have spillover effects on the mental health of people not directly affected. METHODS: In this population-based, quasi-experimental study, we combined novel data on police killings with individual-level data from the nationally representative 2013-15 US Behavioral Risk Factor Surveillance System (BRFSS) to estimate the causal impact of police killings of unarmed black Americans on self-reported mental health of other black American adults in the US general population...
June 21, 2018: Lancet
https://www.readbyqxmd.com/read/29937192/sepsis-and-septic-shock
#14
REVIEW
Maurizio Cecconi, Laura Evans, Mitchell Levy, Andrew Rhodes
Sepsis is a common condition that is associated with unacceptably high mortality and, for many of those who survive, long-term morbidity. Increased awareness of the condition resulting from ongoing campaigns and the evidence arising from research in the past 10 years have increased understanding of this problem among clinicians and lay people, and have led to improved outcomes. The World Health Assembly and WHO made sepsis a global health priority in 2017 and have adopted a resolution to improve the prevention, diagnosis, and management of sepsis...
June 21, 2018: Lancet
https://www.readbyqxmd.com/read/29937191/police-violence-and-the-built-harm-of-structural-racism
#15
Rhea W Boyd
No abstract text is available yet for this article.
June 21, 2018: Lancet
https://www.readbyqxmd.com/read/29914731/transparency-and-accountability-in-astrazeneca-s-access-to-health-care-programmes
#16
LETTER
Katarina Ageborg
No abstract text is available yet for this article.
June 15, 2018: Lancet
https://www.readbyqxmd.com/read/29910042/belimumab-in-kidney-transplantation-an-experimental-medicine-randomised-placebo-controlled-phase-2-trial
#17
Gemma D Banham, Shaun M Flint, Nicholas Torpey, Paul A Lyons, Don N Shanahan, Adele Gibson, Christopher J E Watson, Ann-Marie O'Sullivan, Joseph A Chadwick, Katie E Foster, Rachel B Jones, Luke R Devey, Anna Richards, Lars-Peter Erwig, Caroline O Savage, Kenneth G C Smith, Robert B Henderson, Menna R Clatworthy
BACKGROUND: B cells produce alloantibodies and activate alloreactive T cells, negatively affecting kidney transplant survival. By contrast, regulatory B cells are associated with transplant tolerance. Immunotherapies are needed that inhibit B-cell effector function, including antibody secretion, while sparing regulators and minimising infection risk. B lymphocyte stimulator (BLyS) is a cytokine that promotes B-cell activation and has not previously been targeted in kidney transplant recipients...
June 14, 2018: Lancet
https://www.readbyqxmd.com/read/29910041/immunological-investigations-empower-transplant-drug-trials
#18
Edward K Geissler, James A Hutchinson
No abstract text is available yet for this article.
June 14, 2018: Lancet
https://www.readbyqxmd.com/read/29910040/sodium-bicarbonate-therapy-for-patients-with-severe-metabolic-acidaemia-in-the-intensive-care-unit-bicar-icu-a-multicentre-open-label-randomised-controlled-phase-3-trial
#19
Samir Jaber, Catherine Paugam, Emmanuel Futier, Jean-Yves Lefrant, Sigismond Lasocki, Thomas Lescot, Julien Pottecher, Alexandre Demoule, Martine Ferrandière, Karim Asehnoune, Jean Dellamonica, Lionel Velly, Paër-Sélim Abback, Audrey de Jong, Vincent Brunot, Fouad Belafia, Antoine Roquilly, Gérald Chanques, Laurent Muller, Jean-Michel Constantin, Helena Bertet, Kada Klouche, Nicolas Molinari, Boris Jung
BACKGROUND: Acute acidaemia is frequently observed during critical illness. Sodium bicarbonate infusion for the treatment of severe metabolic acidaemia is a possible treatment option but remains controversial, as no studies to date have examined its effect on clinical outcomes. Therefore, we aimed to evaluate whether sodium bicarbonate infusion would improve these outcomes in critically ill patients. METHODS: We did a multicentre, open-label, randomised controlled, phase 3 trial...
June 14, 2018: Lancet
https://www.readbyqxmd.com/read/29910039/sodium-bicarbonate-for-severe-metabolic-acidaemia
#20
Jeffrey A Kraut, Nicolaos E Madias
No abstract text is available yet for this article.
June 14, 2018: Lancet
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