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European Journal of Medical Research

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https://www.readbyqxmd.com/read/28057086/diagnostic-value-of-microrna-143-in-predicting-in-stent-restenosis-for-patients-with-lower-extremity-arterial-occlusive-disease
#1
Zhi-Hai Yu, Hai-Tao Wang, Can Tu
PURPOSE: This study was conducted to explore the diagnostic value of microRNA-143 (miRNA-143) in predicting in-stent restenosis (ISR) of lower extremity arterial occlusive disease (LEAOD). METHODS: From February 2012 to March 2015, 165 patients (112 males and 53 females) with LEAOD undergoing interventional treatment were enrolled in this study. Serum miRNA-143 expression was detected using quantitative real-time polymerase chain reaction (qRT-PCR). Patients were assigned into the restenosis and non-restenosis groups according to routine surveillance postoperative angiography...
January 5, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28049543/the-level-of-free-circulating-mitochondrial-dna-in-blood-as-predictor-of-death-in-case-of-acute-coronary-syndrome
#2
Nikolay P Sudakov, Konstantin A Apartsin, Svetlana A Lepekhova, Sergey B Nikiforov, Alexander I Katyshev, Galina I Lifshits, Anna V Vybivantseva, Yuri M Konstantinov
BACKGROUND: The efficacy of treating acute myocardial ischemic damages depends, to a large extent, on the development of technologies for predicting their course and outcome. The aim of this paper was to explore whether it would be possible to consider the content of free circulating mitochondrial DNA as a danger-associated molecular pattern for assessing the probability of death from myocardial infarction. METHODS: We have analyzed the clinical outcomes based on discharge summaries and autopsy reports obtained in the course of the PROTOCOL observational trial...
January 3, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/27832813/the-need-for-maximal-sterile-barrier-precaution-in-routine-interventional-coronary-procedures-microbiology-analysis
#3
Avi Peretz, Fabio Kuzniec, Diab Ganem, Nabeeh Salman, Dahud Qarawani, Offer Amir
BACKGROUND: Maximal sterile barrier precautions (MSBP) including head coverings and face masks are advocated for use in invasive procedures, including coronary interventions. The rationale for MSBP assumes it is an obligatory measure for infection prevention. However, in many coronary catheterization laboratories, head coverings/face masks are not used in daily practice. This study prospectively evaluated the potential hazards of not routinely using head coverings/face masks in routine coronary interventions...
November 10, 2016: European Journal of Medical Research
https://www.readbyqxmd.com/read/27809933/is-it-time-to-rebalance-the-case-mix-a-portfolio-analysis-of-direct-catheterization-laboratory-costs-over-a-5-year-period
#4
Gunnar Plehn, Thomas Butz, Petra Maagh, Ahmet Oernek, Axel Meissner, Natalie Plehn
BACKGROUND: Cardiac catheterization laboratories (CLL) have continued to function as profit centers for hospitals. Due to a high percentage of material and labor costs, they are natural targets for process improvement. Our study applied a contribution margin (CBM) concept to evaluate costs and cost dynamics over a 5-year period. METHODS: We retrospectively analyzed all procedures performed at a tertiary heart center between 2007 and 2011. Total variable costs, including labor time, material, and maintenance-expenses, were allocated at a global as well as a procedural level...
November 3, 2016: European Journal of Medical Research
https://www.readbyqxmd.com/read/27802829/detection-of-blood-aspiration-in-deadly-head-gunshots-comparing-postmortem-computed-tomography-pmct-and-autopsy
#5
E Scaparra, O Peschel, C Kirchhoff, M Reiser, S M Kirchhoff
BACKGROUND: The aim of our study was to analyze the reliability of postmortem computed tomography (PMCT) versus autopsy in detecting signs of blood aspiration in a distinct group of patients following deadly head, mouth or floor of mouth gunshot injuries. METHODS: In this study, in 41 cases PMCT was compared to autopsy reports, the gold standard of postmortem exams, regarding detection of blood aspiration. PMCT was evaluated for the presence and level of typical signs of blood aspiration in the major airways and lung using a semi-quantitative scale ranging from level 0 (no aspiration) to 3 (significant aspiration) also taking density values of the described potential aspiratory changes into account...
November 1, 2016: European Journal of Medical Research
https://www.readbyqxmd.com/read/27784330/c5ar-inhibition-in-the-early-inflammatory-phase-does-not-affect-bone-regeneration-in-a-model-of-uneventful-fracture-healing
#6
Christian Ehrnthaller, Markus Huber-Lang, Anna Kovtun, Anna Elise Rapp, Julia Kemmler, Florian Gebhard, Anita Ignatius
BACKGROUND: Recent studies were able to demonstrate involvement of the complement cascade in bone biology. Further studies analyzed the role of complement in traumatic injuries and demonstrated negative effects after excessive systemic activation of the inflammatory response with early abrogation of complement activation after application of a C5aR-antagonist exerting beneficial effects upon bone regeneration. In contrast, own fracture healing experiments with complement-deficient animals implied a crucial role of the complement cascade for sufficient fracture healing...
October 26, 2016: European Journal of Medical Research
https://www.readbyqxmd.com/read/27769294/incidence-of-left-atrial-abnormalities-under-treatment-with-dabigatran-rivaroxaban-and-vitamin-k-antagonists
#7
Stefan Reers, Tolga Agdirlioglu, Michael Kellner, Matthias Borowski, Holger Thiele, Johannes Waltenberger, Michael Reppel
BACKGROUND: Non-vitamin K antagonist oral anticoagulants (NOACs) such as dabigatran or rivaroxaban are alternatives to vitamin K antagonists (VKAs) for prevention of stroke and systemic embolism in patients with atrial fibrillation (AF) and atrial flutter (AFL). Incidences of risk factors for left atrium (LA) and left atrial appendage (LAA) thrombus formation, such as dense spontaneous echo contrast (SEC), low LAA velocity (LAAV) <20 cm/s under treatment with dabigatran and rivaroxaban in comparison with VKAs are unknown...
October 21, 2016: European Journal of Medical Research
https://www.readbyqxmd.com/read/27737718/resuscitation-with-polymeric-plasma-substitutes-is-permissive-for-systemic-inflammatory-response-syndrome-and-sepsis-in-multiply-injured-patients-a-retrospective-cohort-study
#8
Kai Sprengel, Hanspeter Simmen, Clément M L Werner, Simon Sulser, Michael Plecko, Catharina Keller, Ladislav Mica
OBJECTIVE: Multiple trauma is often accompanied by systemic inflammatory response syndrome (SIRS). The aim of this study was to investigate the impact of polymeric plasma substitutes on the development of SIRS or sepsis. METHODS: We included 2969 patients aged ≥16 years with an Injury Severity Score (ISS) >16 in this study. The sample was subdivided into three groups: patients who did not receive colloids and those who received <5L colloids and >5L colloids within the first 48 h...
October 13, 2016: European Journal of Medical Research
https://www.readbyqxmd.com/read/27737712/long-term-disease-free-survival-with-multimodal-therapy-in-small-cell-bladder-cancer
#9
Isabel Heidegger, Gennadi Tulchiner, Georg Schäfer, Wolfgang Horninger, Renate Pichler
BACKGROUND: Small cell bladder cancer (SCBC) is an aggressive subtype accounting for less than 1 % of all bladder malignancies associated with rapid progression, early metastases formation and high mortality rates. CASE PRESENTATION: We present an unusual long term disease free survival of a 60 year-old man who was diagnosed with SCBC two and a half years ago. He underwent four cycles of cisplatin/etoposide chemotherapy as well as a prophylactic whole-brain radiotherapy followed by a radical cystoprostatectomy and ileal neobladder with extended pelvic lymphadenectomy...
October 13, 2016: European Journal of Medical Research
https://www.readbyqxmd.com/read/27729070/cytokine-and-human-leukocyte-antigen-hla-profile-for-graft-versus-host-disease-gvhd-after-organ-transplantation
#10
Xinhua Chen, Xueqin Meng, Yuning Xu, Haiyang Xie, Shengyong Yin, Hongchun Li, Liming Wu, Shusen Zheng
BACKGROUND: Graft-versus-host disease (GVHD) after liver and kidney transplantation has high mortality and causes diagnostic challenges. This study aims to describe the cytokine and human leukocyte antigen (HLA) profile in the GVHD after liver and kidney transplantation. METHODS: A high-throughput detection kit was applied and altogether 18 different cytokines were tested simultaneously. GVHD patients included 23 post-liver transplantation patients; 22 post-renal transplantation patients; The control patients include 22 hepatocellular carcinoma (HCC) patients without transplantation and 20 healthy controls...
October 12, 2016: European Journal of Medical Research
https://www.readbyqxmd.com/read/27716419/the-impact-of-mild-induced-hypothermia-on-the-rate-of-transfusion-and-the-mortality-in-severely-injured-patients-a-retrospective-multi-centre-study
#11
Kai Oliver Jensen, Leonhard Held, Andrea Kraus, Frank Hildebrand, Philipp Mommsen, Ladislav Mica, Guido A Wanner, Peter Steiger, Rudolf M Moos, Hans-Peter Simmen, Kai Sprengel
BACKGROUND: Although under discussion, induced hypothermia (IH) is an established therapy for patients with cardiac arrest or traumatic brain injuries. The influences on coagulopathy and bleeding tendency in severely injured patients (SIP) with concomitant traumatic brain injury are most widely unclear. Therefore, the aim of this study was to quantify the effect of mild IH in SIP with concomitant severe traumatic brain injuries on transfusion rate and mortality. METHODS: In this retrospective multi-centre study, SIP from three European level-1 trauma centres with an ISS ≥16 between 2009 and 2011 were included...
October 6, 2016: European Journal of Medical Research
https://www.readbyqxmd.com/read/27687142/pseudoaneurysm-of-the-anterior-tibial-artery-after-interlocking-tibial-nailing-an-unexpected-complication
#12
F Greve, M Crönlein, M Beirer, C Kirchhoff, P Biberthaler, K F Braun
Anterior tibial pseudoaneurysm is a rare complication after interlocking screw insertion in tibial nailing. We present the case of a 28-year-old male patient with this complication with a 6-week delay after tibial nailing of a right tibial fracture type 42-A1 of the Association for the Study of Internal Fixation (AO/ASIF) classification. On presentation to our emergency department, the patient's complaints were solemnly intermittent pain and occasional swelling of his proximal lower leg. Deep vein thrombosis, compartment syndrome, and implant dislocation were ruled out, and the patient was discharged after his symptoms improved without further intervention...
September 29, 2016: European Journal of Medical Research
https://www.readbyqxmd.com/read/27634174/unplanned-readmissions-in-younger-and-older-adult-patients-the-role-of-healthcare-related-adverse-events
#13
Fabienne J H Magdelijns, Larissa Schepers, Evelien Pijpers, Coen D A Stehouwer, Patricia M Stassen
BACKGROUND: Readmissions are a burden for patients and increase healthcare costs. In Europe, factors associated with readmissions have not yet been extensively investigated. This study aimed to discover factors associated with readmissions in both young and older adult internal medicine patients. Furthermore, we explored the role of healthcare-related adverse events (AEs) in readmissions. METHODS: All patients admitted through the emergency department to the internal medicine department in the last 2 weeks of each month (2011) were included...
September 15, 2016: European Journal of Medical Research
https://www.readbyqxmd.com/read/27582129/safety-of-outpatient-anterior-cervical-discectomy-and-fusion-a-systematic-review-and-meta-analysis
#14
Dexiang Ban, Yang Liu, Taiwei Cao, Shiqing Feng
BACKGROUND: Anterior cervical discectomy and fusion (ACDF) is one of the most prevalent spine surgeries and neurosurgical procedures performed to treat a variety of disorders in the cervical spine. Over the last several years, ACDF has been done in the outpatient setting for less invasive approaches and exposures, as well as modified anesthetic and pain management techniques. Despite the fact that it may be innocuous in other parts of the body, complications in the spine can literally be fatal...
August 31, 2016: European Journal of Medical Research
https://www.readbyqxmd.com/read/27558267/molecular-analysis-of-the-ctsk-gene-in-a-cohort-of-33-brazilian-families-with-pycnodysostosis-from-a-cluster-in-a-brazilian-northeast-region
#15
Thaís Fenz Araujo, Erlane Marques Ribeiro, Anderson Pontes Arruda, Carolina Araujo Moreno, Paula Frassinetti Vasconcelos de Medeiros, Renata Moldenhauer Minillo, Débora Gusmão Melo, Chong Ae Kim, Maria Juliana Rodovalho Doriqui, Têmis Maria Felix, Rodrigo Ambrosio Fock, Denise Pontes Cavalcanti
BACKGROUND: Pycnodysostosis is an autosomal recessive skeletal dysplasia, the prevalence of which is estimated to be low (1 per million). Nevertheless, in recent years we have found 27 affected individuals from 22 families in Ceará State, a region of the Brazilian Northeast, giving a local prevalence of 3 per million. This local prevalence associated with a high parental consanguinity, suggesting a possible founder effect, prompted us to perform a molecular investigation of these families to test this hypothesis...
August 24, 2016: European Journal of Medical Research
https://www.readbyqxmd.com/read/27514645/waiting-time-for-radiation-therapy-after-breast-conserving-surgery-in-early-breast-cancer-a-retrospective-analysis-of-local-relapse-and-distant-metastases-in-615-patients
#16
Raffaella Caponio, Maria Paola Ciliberti, Giusi Graziano, Rocco Necchia, Giovanni Scognamillo, Antonio Pascali, Sabino Bonaduce, Anna Milella, Gabriele Matichecchia, Cristian Cristofaro, Davide Di Fatta, Pasquale Tamborra, Marco Lioce
BACKGROUND: Postoperative radiotherapy after breast-conserving surgery (BCS) is the standard in the management of breast cancer. The optimal timing for starting postoperative radiation therapy has not yet been well defined. In this study, we aimed to evaluate if the time interval between BCS and postoperative radiotherapy is related to the incidence of local and distant relapse in women with early node-negative breast cancer not receiving chemotherapy. METHODS: We retrospectively analyzed clinical data concerning 615 women treated from 1984 to 2010, divided into three groups according to the timing of radiotherapy: ≤60, 61-120, and >120 days...
August 11, 2016: European Journal of Medical Research
https://www.readbyqxmd.com/read/27411303/stem-cell-procedures-in-arthroscopic-surgery
#17
REVIEW
Felix Dyrna, Elmar Herbst, Alexander Hoberman, Andreas B Imhoff, Andreas Schmitt
The stem cell as the building block necessary for tissue reparation and homeostasis plays a major role in regenerative medicine. Their unique property of being pluripotent, able to control immune process and even secrete a whole army of anabolic mediators, draws interest. While new arthroscopic procedures and techniques involving stem cells have been established over the last decade with improved outcomes, failures and dissatisfaction still occur. Therefore, there is increasing interest in ways to improve the healing response...
July 13, 2016: European Journal of Medical Research
https://www.readbyqxmd.com/read/27406233/evaluation-and-clinical-significance-of-cyclin-dependent-kinase5-expression-in-cervical-lesions-a-clinical-research-study-in-guangxi-china
#18
Deng-Hua Pan, Mei-Lin Zhu, Xiao-Miao Lin, Xing-Gu Lin, Rong-Quan He, Yan-Xin Ling, Shi-Tao Su, Madushi Mihiranganee Wickramaarachchi, Yi-Wu Dang, Kang-Lai Wei, Gang Chen
BACKGROUND: Studies have been reported that cyclin-dependent kinase5 (CDK5) was associated with the development of several cancers. However, the relationship between CDK5 level and clinicopathological factors is still poorly understood in cervical diseases. The aim of the current study was to investigate the expression of CDK5 and its clinical significance in variant cervical lesions. METHODS: Immunohistochemistry (IHC) was used to detect CDK5 expression in 54 cases of chronic cervicitis, 42 cases of condyloma acuminate (CA), 38 cases of carcinoma in situ, and 360 cases of cervical cancers [adenocarcinoma, n = 63; squamous cell carcinoma (SCC), n = 263; adenosquamous carcinoma, n = 34]...
July 12, 2016: European Journal of Medical Research
https://www.readbyqxmd.com/read/27364344/modified-hughes-procedure-for-reconstruction-of-large-full-thickness-lower-eyelid-defects-following-tumor-resection
#19
Ahmed M Hishmi, Konrad R Koch, Mario Matthaei, Edwin Bölke, Claus Cursiefen, Ludwig M Heindl
BACKGROUND: Tarsoconjunctival flap advancement, or the Hughes procedure, is among the techniques of choice for reconstructing full-thickness lower eyelid defects so as to restore normal anatomy and function with the best possible cosmetic outcome. The purpose of this study is to report the outcome of a series of patients treated with a modified Hughes procedure following malignant tumor removal. METHODS: This retrospective study included 45 consecutive cases of modified Hughes procedures performed between January 2013 and October 2015...
June 30, 2016: European Journal of Medical Research
https://www.readbyqxmd.com/read/27342975/hdac-inhibition-activates-the-apoptosome-via-apaf1-upregulation-in-hepatocellular-carcinoma
#20
Reena Buurman, Maria Sandbothe, Brigitte Schlegelberger, Britta Skawran
BACKGROUND: Histone deacetylation, a common hallmark in malignant tumors, strongly alters the transcription of genes involved in the control of proliferation, cell survival, differentiation and genetic stability. We have previously shown that HDAC1, HDAC2, and HDAC3 (HDAC1-3) genes encoding histone deacetylases 1-3 are upregulated in primary human hepatocellular carcinoma (HCC). The aim of this study was to characterize the functional effects of HDAC1-3 downregulation and to identify functionally important target genes of histone deacetylation in HCC...
June 24, 2016: European Journal of Medical Research
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