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European Journal of Medical Research

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https://www.readbyqxmd.com/read/29145895/comparative-analysis-of-high-sensitivity-cardiac-troponin-i-and-t-for-their-association-with-coronary-computed-tomography-assessed-calcium-scoring-represented-by-the-agatston-score
#1
Jonas Rusnak, Michael Behnes, Thomas Henzler, Nadine Reckord, Nils Vogler, Mathias Meyer, Ursula Hoffmann, Michele Natale, Julia Hoffmann, Sonja Hamed, Kathrin Weidner, Siegfried Lang, Agnibh Mukherji, Holger Haubenreisser, Stefan O Schoenberg, Martin Borggrefe, Thomas Bertsch, Ibrahim Akin
BACKGROUND: This study evaluates the association between high-sensitivity cardiac troponin I (hs-cTnI) and T (hs-cTnT) and coronary calcium concentration (CAC) detected by coronary computed tomography (CCT) and evaluated with the Agatston score in patients with suspected coronary artery disease (CAD). METHODS: Patients undergoing CCT during routine clinical care were enrolled prospectively. CCT was indicated for patients with a low to intermediate pretest probability for CAD...
November 16, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/29141690/resternotomy-does-not-adversely-affect-outcome-after-left-ventricular-assist-device-implantation
#2
Maria Papathanasiou, Loukas Tsourelis, Nikolaus Pizanis, Achim Koch, Markus Kamler, Tienush Rassaf, Peter Luedike
BACKGROUND: Resternotomy in cardiac surgery is considered a risk factor for postoperative complications. Previous studies have demonstrated an ambiguous relationship between resternotomy and clinical outcomes. Registry data from a mixed population of durable circulatory support devices suggest that history of cardiac surgery is a risk factor for mortality. Our study investigates the prognostic significance of resternotomy in a homogenous cohort of left ventricular assist device (LVAD) recipients...
November 15, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/29122013/suppression-of-methylmercury-induced-mip-2-expression-by-n-acetyl-l-cysteine-in-murine-raw264-7-macrophage-cell-line
#3
Juliet David, Athira Nandakumar, Muflihatul Muniroh, Suminori Akiba, Megumi Yamamoto, Chihaya Koriyama
BACKGROUND: The aim of this study is to examine the inflammatory-cytokine expressions in the presence of non-cytotoxic dose of methylmercury (MeHg) in murine macrophages, which is suspected to play an important role in brain damage caused by MeHg exposure. We focused on murine macrophage inflammatory protein-2 (MIP-2), keratinocyte chemoattractant (KC), and monocyte chemoattractant protein-5 (MCP-5). MIP-2 and KC are murine functional homologues of human IL-8 and MCP-5 for human MCP-1...
November 9, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/29084612/long-term-outcome-in-324-polytrauma-patients-what-factors-are-associated-with-posttraumatic-stress-disorder-and-depressive-disorder-symptoms
#4
Lisa Falkenberg, Christian Zeckey, Philipp Mommsen, Marcel Winkelmann, Boris A Zelle, Martin Panzica, Hans-Christoph Pape, Christian Krettek, Christian Probst
BACKGROUND: Physical impairment is well-known to last for many years after a severe injury, and there is a high impact on the quality of the survivor's life. The purpose of this study was to examine if this is also true for psychological impairment with symptoms of posttraumatic stress disorder or depression after polytrauma. DESIGN: Retrospective cohort outcome study. SETTING: Level I trauma centre. POPULATION: 637 polytrauma trauma patients who were treated at our Level I trauma centre between 1973 and 1990...
October 30, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/29070064/the-effects-of-body-weight-loss-and-gain-on-arterial-hypertension-control-an-observational-prospective-study
#5
Peter Sabaka, Andrej Dukat, Jan Gajdosik, Matej Bendzala, Martin Caprnda, Fedor Simko
BACKGROUND: Body weight changes are associated with significant variations in blood pressure (BP). Body mass modifications may, therefore, influence hypertension control in primary care. METHODS: Patients with a history of essential arterial hypertension were observed for 12 months. Anthropometric data and clinical BP were evaluated at the time of the recruitment and after 12 months of follow-up. The association between (body mass index) BMI change and BP control was analyzed by logistic regression...
October 25, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/29047400/observation-of-the-influences-of-diosgenin-on-aging-ovarian-reserve-and-function-in-a-mouse-model
#6
Mingjie Shen, Cong Qi, Yan-Ping Kuang, Yang Yang, Qi-Feng Lyu, Hui Long, Zhi-Guang Yan, Ying-Yu Lu
BACKGROUND: The aim of this study was to investigate the impact of diosgenin, an important monomer of sapogenins in yams, on ovarian reserve in a natural aging mice model. STUDY DESIGN: This randomized controlled trial included 60 9-month-old C57 naturally aging female mice. Twenty-one mice were assigned to the dio group and were fed a single dose of diosgenin (200 mg/kg/day) suspended in 0.3% CMC. Twenty mice were assigned to the DHEA group and were fed a single dose of DHEA (1...
October 18, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/29020986/colorectal-cancer-infiltrating-t-lymphocytes-display-a-distinct-chemokine-receptor-expression-profile
#7
Ann-Britt Löfroos, Mohammad Kadivar, Sabina Resic Lindehammer, Jan Marsal
BACKGROUND: T lymphocytes exert important homeostatic functions in the healthy intestinal mucosa, whereas in case of colorectal cancer (CRC), infiltration of T lymphocytes into the tumor is crucial for an effective anti-tumor immune response. In both situations, the recruitment mechanisms of T lymphocytes into the tissues are essential for the immunological functions deciding the outcome. The recruitment of T lymphocytes is largely dependent on their expression of various chemokine receptors...
October 11, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/29020984/fully-digital-data-processing-during-cardiovascular-implantable-electronic-device-follow-up-in-a-high-volume-tertiary-center
#8
Ingo Staudacher, Asha Roy Nalpathamkalam, Lorenz Uhlmann, Claudius Illg, Sebastian Seehausen, Mohammadreza Akhavanpoor, Anke Buchauer, Nicolas Geis, Patrick Lugenbiel, Patrick A Schweizer, Panagiotis Xynogalos, Maura M Zylla, Eberhard Scholz, Edgar Zitron, Hugo A Katus, Dierk Thomas
BACKGROUND: Increasing numbers of patients with cardiovascular implantable electronic devices (CIEDs) and limited follow-up capacities highlight unmet challenges in clinical electrophysiology. Integrated software (MediConnect(®)) enabling fully digital processing of device interrogation data has been commercially developed to facilitate follow-up visits. We sought to assess feasibility of fully digital data processing (FDDP) during ambulatory device follow-up in a high-volume tertiary hospital to provide guidance for future users of FDDP software...
October 11, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/29020977/platelet-rich-plasma-stimulates-angiogenesis-in-mice-which-may-promote-hair-growth
#9
Hanxiao Cheng, Jufang Zhang, Jinsheng Li, Ming Jia, Yuyan Wang, Haiyan Shen
BACKGROUND: Platelet-rich plasma (PRP) is an autologous concentration of human platelets in plasma. In this paper, we aimed to investigate the effect of PRP on hair growth. METHODS: Platelet-rich plasma and platelet-poor plasma were prepared by sterile centrifugation and injected into shaved dorsal skin of mice (n = 10). Saline injection was used in the control group. The length of randomly plucked hairs was measured at 8, 13, 18 days after PRP injection. Histological examination was preformed to observe the histologic changes of skins...
October 11, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28978339/high-sensitivity-troponin-t-and-i-reflect-mitral-annular-plane-systolic-excursion-being-assessed-by-cardiac-magnetic-resonance-imaging
#10
Michèle Natale, Michael Behnes, Seung-Hyun Kim, Julia Hoffmann, Nadine Reckord, Ursula Hoffmann, Johannes Budjan, Siegfried Lang, Martin Borggrefe, Theano Papavassiliu, Thomas Bertsch, Ibrahim Akin
PURPOSE: This study aims to evaluate the association between high sensitivity troponins (hsTn) and mitral annular plane systolic excursion (MAPSE) in patients undergoing cardiac magnetic resonance imaging (cMRI). METHODS: Patients undergoing cMRI were prospectively enrolled. Patients with right ventricular dysfunction (< 50%) were excluded. Blood samples for measurements of hsTn and amino-terminal pro-brain natriuretic peptide (NT-proBNP) were collected at the time of cMRI...
October 4, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28974249/erratum-to-cytokine-and-human-leukocyte-antigen-hla-profile-for-graft-versus-host-disease-gvhd-after-organ-transplantation
#11
Xinhua Chen, Xueqin Meng, Yuning Xu, Haiyang Xie, Shengyong Yin, Hongchun Li, Liming Wu, Shusen Zheng
Following publication of the original article [1], the authors requested a correction in the presentation of their institutions as they appear on the Web of Science. Specifically, it should be emphasized that the institutions belong to Zhejiang University. The correct presentation of affiliations is given in this erratum.
October 3, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28962650/developing-a-risk-prediction-model-for-breast-cancer-a-statistical-utility-to-determine-affinity-of-neoplasm-sudan-ca-breast
#12
Alaaddin M Salih, Dafallah M Alam-Elhuda, Musab M Alfaki, Adil E Yousif, Momin M Nouradyem
BACKGROUND: Breast cancer risk prediction models are widely used in clinical settings. Although most of the well-known models were designed based on data collected from western population, yet they have been utilized for surveillance purposes in many limited-resource countries. Given the genetic variations in risk factors that exist between different races, we therefore aimed to develop and validate a tool for breast cancer risk assessment among Sudanese women. METHODS: Using cross-sectional design, 153 subjects were eligible to participate in our study...
September 29, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28962640/trunk-and-craniofacial-asymmetry-are-not-associated-in-the-general-population-a-cross-sectional-study-of-1029-adolescents
#13
Chiara Arienti, Jorge Hugo Villafañe, Sabrina Donzelli, Fabio Zaina, Riccardo Buraschi, Stefano Negrini
BACKGROUND: The literature did not show clearly if a correlation between trunk and facial asymmetry exists. The aim of this study was to verify the association between trunk and facial asymmetries, and trunk and facial sagittal configuration in adolescents. METHODS: This is a cross-sectional screening study. It was carried out in a small town in Northern Italy, from February to April 2014. Healthy children met the inclusion criteria. Exclusion criteria were subjects with physical and cognitive disability, genetic disease, and polymorphism...
September 29, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28938917/clinical-and-biometrical-12-month-follow-up-in-patients-after-reconstruction-of-the-sural-nerve-biopsy-defect-by-the-collagen-based-nerve-guide-neuromaix
#14
Ahmet Bozkurt, Kristl G Claeys, Simone Schrading, Jana V Rödler, Haktan Altinova, Jörg B Schulz, Joachim Weis, Norbert Pallua, Sabien G A van Neerven
Many new strategies for the reconstruction of peripheral nerve injuries have been explored for their effectiveness in supporting nerve regeneration. However only a few of these materials were actually clinically evaluated and approved for human use. This open, mono-center, non-randomized clinical study summarizes the 12-month follow-up of patients receiving reconstruction of the sural nerve biopsy defect by the collagen-based nerve guide Neuromaix. Neuromaix was implanted as a micro-structured, two-component scaffold bridging 20-40 mm nerve defects after sural nerve biopsy in twenty patients (eighteen evaluated, two lost in follow-up)...
September 22, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28931437/acute-reverse-annular-remodeling-during-mitraclip-%C3%A2-therapy-predicts-improved-clinical-outcome-in-heart-failure-patients-a-3d-echocardiography-study
#15
Theresa Herbrand, Silke Eschenhagen, Tobias Zeus, Eva Kehmeier, Katharina Hellhammer, Verena Veulemans, Malte Kelm, Jan Balzer
BACKGROUND: Transcatheter mitral valve repair (TMVR) has been shown to have acute effects on mitral valve geometry in patients with functional mitral regurgitation (FMR). This study investigates the impact of MitraClip(®) therapy-induced annular remodeling on clinical outcome and mitral regurgitation in heart failure patients. METHODS: TMVR was performed successfully in 45 patients with FMR. In this study, mitral valve datasets were obtained before and directly after MitraClip(®) implantation using three-dimensional (3D) transesophageal echocardiography, and were analyzed offline retrospectively using dedicated 3D reconstruction software...
September 20, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28927464/cervical-cancer-screening-behavior-and-associated-factors-among-women-of-ugrachandi-nala-kavre-nepal
#16
Radha Acharya Pandey, Era Karmacharya
BACKGROUND: Cervical cancer in Nepal ranks as the first most frequent cancer among women. Primary prevention measures, such as prophylactic vaccines against high risk HPV, are now available. Over time, vaccination will decrease the prevalence of the disease among younger women; however, screening will still be needed. The objective of the study was to assess the cervical cancer screening behavior and its associated factors among women of Nala Village Development Committee (VDC), Kavre...
September 19, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28886732/optimized-protocol-for-whole-organ-decellularization
#17
A Schmitt, R Csiki, A Tron, B Saldamli, J Tübel, K Florian, S Siebenlist, E Balmayor, R Burgkart
BACKGROUND: The idea of tissue decellularization to gain matrices for tissue engineering is promising. The aim of the present study is to establish a safe and reproducible protocol for solid tissue decellularization that prevents the architecture of the matrix with the inherent vascular network. METHODS: The study was performed in rat kidneys which were decellularized by a SDS-based perfusion protocol. Perfusion time and SDS concentration were systematically changed to obtain the shortest and most gentle protocol that leads to complete decellularization...
September 8, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28854966/using-automated-texture-features-to-determine-the-probability-for-masking-of-a-tumor-on-mammography-but-not-ultrasound
#18
Lothar Häberle, Carolin C Hack, Katharina Heusinger, Florian Wagner, Sebastian M Jud, Michael Uder, Matthias W Beckmann, Rüdiger Schulz-Wendtland, Thomas Wittenberg, Peter A Fasching
BACKGROUND: Tumors in radiologically dense breast were overlooked on mammograms more often than tumors in low-density breasts. A fast reproducible and automated method of assessing percentage mammographic density (PMD) would be desirable to support decisions whether ultrasonography should be provided for women in addition to mammography in diagnostic mammography units. PMD assessment has still not been included in clinical routine work, as there are issues of interobserver variability and the procedure is quite time consuming...
August 30, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28830502/relationship-between-gnas1-t393c-polymorphism-and-aseptic-loosening-after-total-hip-arthroplasty
#19
Patrick Stelmach, Max D Kauther, Lena Fuest, Gina Kurscheid, Thorsten Gehrke, Stefanie Klenke, Marcus Jäger, Christian Wedemeyer, Hagen S Bachmann
BACKGROUND: Aseptic loosening is a main cause for revision surgery after total hip arthroplasty (THA) and there is no reliable marker for the early detection of patients at high risk. This study has been performed to validate association of the T393C polymorphism (rs7121) in the GNAS1 gene, encoding for the alpha-subunit of heterotrimeric G-protein Gs, with risk for and time to aseptic loosening after THA, which has been demonstrated in our previous study. METHODS: 231 patients with primary THA and 234 patients suffering from aseptic loosening were genotyped for dependency on GNAS1 genotypes and analyzed...
August 23, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28807013/microneedle-physical-contact-as-a-therapeutic-for-abnormal-scars
#20
David C Yeo, Elizabeth R Balmayor, Jan-Thorsten Schantz, Chenjie Xu
BACKGROUND: Abnormal (keloid and hypertrophic) scars are a significant affliction with no satisfactory single modality therapy to-date. Available options are often ineffective, painful, potentially hazardous, and require healthcare personnel involvement. Herein a self-administered microneedle device based on drug-free physical contact for inhibiting abnormal scars is reported. Its therapeutic activity through microneedle contact eliminates hazards associated with toxic anti-scarring drugs while self-treatment enables administration flexibility...
August 14, 2017: European Journal of Medical Research
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