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European Journal of Medical Research

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https://www.readbyqxmd.com/read/30606260/cardio-oncology-need-for-novel-structures
#1
EDITORIAL
Lars Michel, Tienush Rassaf
Cancer and cardiovascular diseases are the main causes for morbidity and mortality in modern society. In the United States of America (USA), over 1.7 million new cancer cases will presumably be observed in 2018. Progress in cancer treatment has greatly improved survival and it is estimated that 15.5 million cancer survivors currently live in the USA. The number of cancer survivors is expected to increase by 68% until 2040. Moreover, the portion of cancer survivors at the age of 65 years or older will increase from 62% to approximately 73% in 2040 which in turn enhances comorbidities in cancer survivors...
January 3, 2019: European Journal of Medical Research
https://www.readbyqxmd.com/read/30587237/association-between-bisphenol-a-diglycidyl-ether-specific-igg-in-serum-and-food-sensitization-in-young-children
#2
Mayumi Tsuji, Chihaya Koriyama, Yasuhiro Ishihara, Christoph F A Vogel, Toshihiro Kawamoto
BACKGROUND: Recent studies have reported that endocrine-disrupting compound (EDC) exposure is related to food sensitization. Bisphenol A diglycidyl ether (BADGE) is one of the most widespread EDCs and its biological effects are considered to be greater on children than on adults. This study investigated the relationship between serum BADGE-specific immunoglobulin G (IgG) concentrations and food sensitization in young children by measuring food-specific IgE levels. METHODS: In total, 98 young children (59 boys and 39 girls; median age: 7 months; 25th and 75th percentile ages: 6 and 8 months, respectively) were enrolled...
December 26, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/30585140/occlusive-dressing-induced-secretomes-influence-the-migration-and-proliferation-of-mesenchymal-stem-cells-and-fibroblasts-differently
#3
Michael K Cerny, Ursula Hopfner, Manuela Kirsch, Elisabeth-Maria Haas, Fan Wu, Riccardo Giunta, Hans-Guenther Machens, Dominik Duscher, Holger Erne, Arndt F Schilling
BACKGROUND: Fingertip injuries treated with occlusive dressings (ODs) lead to nearly scar-free, functionally, and aesthetically pleasing results. We hypothesized that paracrine factors in the wound fluid (secretome) may influence migration and proliferation of mesenchymal stem cells (MSCs) and fibroblasts and modulate the wound-healing process. METHODS: We could collect wound fluid samples from 4 fingertip injuries and 7 split skin donor sites at the 5th day during dressing change...
December 26, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/30526681/noise-insertion-in-ct-for-cocaine-body-packing-where-is-the-limit-of-extensive-dose-reduction
#4
Joel Aissa, Edwin Bölke, Lino M Sawicki, Elisabeth Appel, Christoph Thomas, Philipp Heusch, Martin Sedlmair, Karl Krzymyk, Patric Kröpil, Gerald Antoch, Johannes Boos
BACKGROUND: To evaluate the detection rate and image quality in CT-body-packer-screening at different radiation-dose levels and to determine a dose threshold that enables a reliable detection of incorporated body packs and incidental findings with a maximum of dose saving. MATERIALS AND METHODS: We retrospectively included 27 individuals who underwent an abdominal CT with automated exposure control due to suspected body packing. CT images were reconstructed at different radiation-dose levels of 50%, 10, 5% and 1% using iterative reconstructions...
December 7, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/30446006/transcanalicular-laser-dacryocystorhinostomy-for-acquired-nasolacrimal-duct-obstruction-an-audit-of-104-patients
#5
Joel M Mor, Mario Matthaei, Holger Schrumpf, Konrad R Koch, Edwin Bölke, Ludwig M Heindl
PURPOSE: External dacryocystorhinostomy (DCR) is considered as the gold standard in the treatment of acquired nasolacrimal duct obstruction. However, many advances have been made towards the development of modern minimally invasive therapies. These new techniques were proven less harmful to the patients' skin and medial palpebral structures with their palpebral-canalicular pump mechanism. Options include endonasal and transcanalicular procedures. Here, we report on our 2-year experience with the surgical technique, results and complications of transcanalicular laser-assisted DCR...
November 16, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/30414615/the-effect-of-statin-treatment-on-circulating-coenzyme-q10-concentrations-an-updated-meta-analysis-of-randomized-controlled-trials
#6
REVIEW
Hua Qu, Yan-Yan Meng, Hua Chai, Fang Liang, Jia-Yi Zhang, Zhu-Ye Gao, Da-Zhuo Shi
BACKGROUND: The effect of statin treatment on circulating coenzyme Q10 (CoQ10) has been studied in numerous randomized controlled trails (RCTs). However, whether statin treatment decreases circulating CoQ10 is still controversial. METHODS: PubMed, EMBASE, and the Cochrane Library were searched to identify RCTs to investigate the effect of statin treatment on circulating CoQ10. We calculated the pooled standard mean difference (SMD) using a fixed effect model or random effect model to assess the effect of statin treatment on circulating CoQ10...
November 10, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/30413175/early-endothelial-progenitor-cells-and-vascular-stiffness-in-psoriasis-and-psoriatic-arthritis
#7
D Patschan, N Sugiarto, E Henze, R Mößner, J Mohr, G A Müller, S Patschan
BACKGROUND: Both psoriasis (Ps) and psoriasis arthritis (PsA) have been associated with increased cardiovascular risk. Also, both are characterized by increased neovascularization. Endothelial progenitor cells (EPCs) have been implicated in promoting vascular repair in ischemic diseases. The aim of the study was to correlate the EPC system with CV risk factors and with parameters of vascular stiffness in Ps and PsA. METHODS: Twenty-six healthy subjects, 30 patients with Ps, and 31 patients PsA were included in the study...
November 9, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/30390707/microrna-profiling-of-diabetic-atherosclerosis-in-a-rat-model
#8
Yuejin Li, Le Xiao, Jinyuan Li, Ping Sun, Lei Shang, Jian Zhang, Quan Zhao, Yiming Ouyang, Linhai Li, Kunmei Gong
OBJECTIVE: The incidence of diabetic atherosclerosis (DA) is increasing worldwide. The study aim was to identify differentially expressed microRNAs (DE-miRs) potentially associated with the initiation and/or progression of DA, thereby yielding new insights into this disease. METHODS: Matched iliac artery tissue samples were isolated from 6 male rats with or without DA. The Affymetrix GeneChip microRNA 4.0 Array was used to detect miRs. Differential expression between atherosclerotic group and non-atherosclerotic group samples was analyzed using the Gene-Cloud of Biotechnology Information platform...
November 3, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/30382881/skarzynski-tinnitus-scale-validation-of-a-brief-and-robust-tool-for-assessing-tinnitus-in-a-clinical-population
#9
Henryk Skarżyński, Elżbieta Gos, Danuta Raj-Koziak, Piotr H Skarżyński
BACKGROUND: Many tinnitus scales are available, but all of them have certain limitations. The aim of the current study was to present a psychometric data of a new brief and reliable questionnaire that could be conveniently used for evaluating tinnitus complaint in adults (either with normal or impaired hearing)-Skarzynski Tinnitus Scale (STS). METHODS: The study included 125 participants with at least 1 month of tinnitus duration. All participants were asked to complete the STS, Tinnitus and Hearing Survey (THS), Tinnitus Functional Index (TFI), Tinnitus Handicap Inventory (THI), and Beck Depression Inventory...
November 1, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/30355363/treatment-of-onychomycosis-using-a-1064-nm-diode-laser-with-or-without-topical-antifungal-therapy-a-single-center-retrospective-analysis-in-56-patients
#10
G C Weber, P Firouzi, A M Baran, E Bölke, H Schrumpf, B A Buhren, B Homey, P A Gerber
BACKGROUND: Currently available treatment options for onychomycosis such as topical and systemic antifungals are often of limited efficacy, difficult to administer or associated with relevant side effects. Non-ablative laser therapy is proposed to represent a safe alternative without the disadvantages of drugs. Yet, to date, the efficacy of laser therapy for onychomycosis is discussed controversially. Against this background, we performed a systematic retrospective analysis of our clinical experience of 4 years of onychomycosis treatment applying a long-pulsed 1...
October 24, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/30355362/a-phase-i-ii-controlled-randomized-trial-using-a-promising-novel-cell-free-formulation-for-articular-cartilage-regeneration-as-treatment-of-severe-osteoarthritis-of-the-knee
#11
Ivan Delgado-Enciso, Juan Paz-Garcia, Jose Valtierra-Alvarez, Jorge Preciado-Ramirez, Roman Almeida-Trinidad, Jose Guzman-Esquivel, Martha A Mendoza-Hernandez, Alberto Garcia-Vega, Alejandro D Soriano-Hernandez, Jose L Cortes-Bazan, Hector R Galvan-Salazar, Ariana Cabrera-Licona, Iram P Rodriguez-Sanchez, Margarita L Martinez-Fierro, Josuel Delgado-Enciso, Brenda Paz-Michel
BACKGROUND: A promising novel cell-free bioactive formulation for articular cartilage regeneration, called BIOF2, has recently been tested in pre-clinical trials. The aim of the present study was to evaluate the efficacy and safety of BIOF2 for intra-articular application in patients with severe osteoarthritis of the knee. METHODS: A prospective, randomized, 3-arm, parallel group clinical trial was conducted. It included 24 patients with severe osteoarthritis of the knee (WOMAC score 65...
October 24, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/30352632/frequency-of-atrial-thrombus-formation-in-patients-with-atrial-fibrillation-under-treatment-with-non-vitamin-k-oral-anticoagulants-in-comparison-to-vitamin-k-antagonists-a-systematic-review-and-meta-analysis
#12
REVIEW
Stefan Reers, Georg Karanatsios, Matthias Borowski, Michael Kellner, Michael Reppel, Johannes Waltenberger
BACKGROUND: To assess the frequency of left atrium/left atrial appendage (LA/LAA) thrombus under treatment with non-vitamin K oral anticoagulants (NOACs) in comparison with vitamin K antagonists (VKAs) in patients with non-valvular atrial fibrillation (AF). METHODS: PubMed, Web of Science™, EMBASE and the Cochrane Library databases were searched for studies comparing NOACs with VKAs in AF patients who underwent diagnostic transoesophageal echocardiography (TEE)...
October 23, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/30352629/donor-liver-quality-after-hypovolemic-shock-and-venous-systemic-oxygen-persufflation-in-an-experimental-animal-model
#13
Azin Jafari, Hanno Matthaei, Vittorio Branchi, Edwin Bölke, Rene H Tolba, Jörg C Kalff, Steffen Manekeller
BACKGROUND: The ever growing demand for liver transplantation inevitably necessitates an expansion of the donor pool. Utilization of "shock organs" is considered suboptimal to date while the associated outcome has hardly been investigated. MATERIALS AND METHODS: Male Wistar rats underwent a period of 30 min of hypovolemic shock. After 24 h livers were explanted and prior to reperfusion underwent either 18 h of cold storage (CS; N = 6) or 17 h of CS followed by 60 min venous systemic oxygen persufflation (VSOP; N = 6)...
October 23, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/30352622/analysis-of-the-bony-geometry-of-the-acromio-clavicular-joint
#14
Moritz Crönlein, Lukas Postl, Marc Beirer, Dominik Pförringer, Jennifer Lang, Frederik Greve, Michael Müller, Peter Biberthaler, Chlodwig Kirchhoff
BACKGROUND: The primary goal of this study was to analyse the anatomic configuration of the acromio-clavicular joint in a healthy population to be able to develop a classification in a second step. On the basis of the primary findings a secondary goal was to find potential clinical indications in refer to AC-joint dislocation and lateral clavicle fractures. METHODS: The upper thoracic aperture including both shoulder joints as well as both sterno-clavicular joints was retrospectively reformatted in a bone kernel in axial orientation with 0...
October 23, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/30342556/screening-breast-magnetic-resonance-imaging-in-women-with-hormone-replacement-therapy
#15
Feng Zhang, Qingjing Feng, Zhiyong Zhang, Yanjun Hu, Zhifeng Zhang
OBJECTIVE: The objective of this study was to compare the performance of screening mammography versus magnetic resonance imaging (MRI) in hormone replacement therapy (HRT) users. METHODS: We performed a retrospective review of 4628 women who had mammography or breast MRI screening from the beginning of HRT use at three institutions from April 2005 to December 2015. Information of demographics, number of biopsies performed and pathologic outcomes were collected. Sensitivity, specificity, negative predictive value (NPV) and positive predictive value (PPV) of screening mammography and MRI were compared...
October 20, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/30309383/no-association-of-tp53-codon-72-and-intron-3-16-bp-duplication-polymorphisms-with-breast-cancer-risk-in-chinese-han-women-new-evidence-from-a-population-based-case-control-investigation
#16
Weiming Hao, Xia Xu, Haifeng Shi, Chiyu Zhang, Xiaoxiang Chen
BACKGROUND: Many studies have demonstrated that the genetic variants of tumor suppressor gene TP53 contribute to the prediction of breast cancer risk. However, most of them focused on Europeans and Americans; the investigations about Asians, especially Chinese women, are scarce. Thus, the aim of this study was to explore the influence of TP53 codon 72 and intron 3 16-bp duplication polymorphisms on the breast cancer risk in Chinese women, especially those from eastern China. METHODS: Blood samples collected from 254 breast cancer patients and 252 healthy female individuals were investigated...
October 11, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/30266100/the-munich-ankle-questionnaire-maq-a-self-assessment-tool-for-a-comprehensive-evaluation-of-ankle-disorders
#17
Frederik Greve, Karl Friedrich Braun, Veronika Vitzthum, Michael Zyskowski, Michael Müller, Chlodwig Kirchhoff, Peter Biberthaler, Marc Beirer
BACKGROUND: There are many approved patient-related outcome measurement tools regarding ankle pathologies. However, there is none incorporating the range of motion (ROM) as an objective parameter. Most instruments focus on subjective parameters such as pain and impairment at work or daily living. Furthermore, the majority is only applicable to a specific pathology. Therefore, the objective of our study was to develop and validate the Munich Ankle Questionnaire (MAQ) as a universal self-assessment score including subjective and objective items...
September 28, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/30266096/ingenol-mebutate-induces-a-tumor-cell-directed-inflammatory-response-and-antimicrobial-peptides-thereby-promoting-rapid-tumor-destruction-and-wound-healing
#18
Stephan Alexander Braun, Julia Baran, Holger Schrumpf, Bettina Alexandra Buhren, Edwin Bölke, Bernhard Homey, Peter Arne Gerber
BACKGROUND: Ingenol mebutat (IM)-gel is effective for the topical treatment of epithelial tumors, including actinic keratoses (AKs) or anogenital warts (AGW). AK patients treated with IM develop intensified inflammatory reactions on sights of prior clinical visible or palpable AKs as compared to the surrounding actinically damaged skin, suggesting the induction of a tumor cell-directed inflammation. AGW patients treated with IM develop even stronger inflammatory reactions with large erosions, suggesting a directed inflammatory response against HPV-infected keratinocytes...
September 28, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/30219102/prospective-randomized-controlled-trial-in-the-treatment-of-lateral-epicondylitis-with-a-new-dynamic-wrist-orthosis
#19
J Nowotny, B El-Zayat, J Goronzy, A Biewener, F Bausenhart, S Greiner, P Kasten
BACKGROUND: In the treatment of lateral epicondylitis (LE), the role of a new dynamic wrist orthosis is unclear. PATIENTS AND METHODS: Patients suffering from a LE longer than 3 months were multicentrically and prospectively randomized into a physiotherapeutic group (PT group) and in a physiotherapy group plus wrist orthosis (PT + O group). Physiotherapy consisted of daily eccentric strengthening exercises under initial professional supervision. Inclusion criteria were a Placzek score greater than 4...
September 15, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/30219097/polymorphonuclear-pmn-elastase-in-patients-after-severe-traumatic-brain-injury
#20
Lukas Kurt Postl, Viktoria Bogner, Martijn van Griensven, Marc Beirer, Karl Georg Kanz, Christoph Egginger, Peter Biberthaler, Chlodwig Kirchhoff
BACKGROUND: Data on PNM elastase levels in cerebrospinal fluid following traumatic brain injury (TBI) in humans are not available in the literature. Therefore, the aim of this prospective study was to evaluate the dynamics of PMN elastase in the cerebrospinal fluid (CSF) of patients after TBI. METHODS: Patients suffering from isolated, closed TBI, presenting with an initial Glasgow coma score ≤ 8 and with intracerebral hemorrhage on the initial cranial computed tomography scan (performed within 90 min after TBI) were enrolled...
September 15, 2018: European Journal of Medical Research
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