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European Journal of Medical Research

J Nowotny, B El-Zayat, J Goronzy, A Biewener, F Bausenhart, S Greiner, P Kasten
BACKGROUND: In the treatment of lateral epicondylitis (LE), the role of a new dynamic wrist orthosis is unclear. PATIENTS AND METHODS: Patients suffering from a LE longer than 3 months were multicentrically and prospectively randomized into a physiotherapeutic group (PT group) and in a physiotherapy group plus wrist orthosis (PT + O group). Physiotherapy consisted of daily eccentric strengthening exercises under initial professional supervision. Inclusion criteria were a Placzek score greater than 4...
September 15, 2018: European Journal of Medical Research
Lukas Kurt Postl, Viktoria Bogner, Martijn van Griensven, Marc Beirer, Karl Georg Kanz, Christoph Egginger, Peter Biberthaler, Chlodwig Kirchhoff
BACKGROUND: Data on PNM elastase levels in cerebrospinal fluid following traumatic brain injury (TBI) in humans are not available in the literature. Therefore, the aim of this prospective study was to evaluate the dynamics of PMN elastase in the cerebrospinal fluid (CSF) of patients after TBI. METHODS: Patients suffering from isolated, closed TBI, presenting with an initial Glasgow coma score ≤ 8 and with intracerebral hemorrhage on the initial cranial computed tomography scan (performed within 90 min after TBI) were enrolled...
September 15, 2018: European Journal of Medical Research
Jörg Nowotny, Sebastian Löbstein, Achim Biewener, Guido Fitze, Philip Kasten
BACKGROUND: Chondral or osteochondral lesions, post-traumatic contracture and loose bodies of the elbow are often associated with chronic pain, stiffness, repetitive swelling and joint blockages. Therefore, arthroscopy of the elbow is often used in the elderly for the treatment of osteochondral defects or arthrolysis. There are only a few reports and studies about arthroscopic therapy of the elbow in children and adolescents. This study assesses the clinical outcome of arthroscopic therapy in this age group...
September 15, 2018: European Journal of Medical Research
Hong-Wei Chen, Xiao-Feng Teng
BACKGROUND: The coracoid process plays an important role in maintaining the stability of the elbow joint. A fracture of the coronoid process is often treated via surgical approaches, including open reduction and internal fixation, which aim to regain a stable, flexible, and loadable joint. In this study, we compared the anterior, medial, and posterior approaches of internal fixation in the repair of fractures of the coronoid process of the ulna. METHODS: In this retrospective study, 147 patients with fractures in the coronoid process of the ulna were recruited and classified into the anterior group (n = 73), the medial group (n = 32), and the posterior group (n = 42) according to the surgical approach used for internal fixation...
September 11, 2018: European Journal of Medical Research
Fatma Celik, Ipek S Edipoglu
BACKGROUND: Preoperative anxiety is one of the most important problems for the patients, because it causes emotional and psychiatric problems as well as physical problems. It is crucial to detect the patient's existing anxiety to assist patients. Our primary aim in this study is to investigate how the patient's age, gender, the operation, surgical briefing, type of anesthesia recommended for the operation ahead, and patient's prior anesthesia experience affect the patient's anxieties...
September 11, 2018: European Journal of Medical Research
Benedikt Peterburs, Anke Mittelstaedt, Philipp Haas, Maximilian Petri, Ralf Westphal, Christian Dullin, Stephan Sehmisch, Claudia Neunaber
BACKGROUND: Reduction of femoral shaft fractures remains a challenging problem in orthopaedic surgery. Robot-assisted reduction might ease reduction and fracture treatment. However, the influence of different reduction pathways on patients' physiology is not fully known yet. Therefore, the aim of this study was to examine the biomechanics and histology of fracture healing after direct and prolonged robot-assisted reduction in an in vivo rat model. METHODS: 144 male CD® rats were randomly assigned to 12 groups...
September 4, 2018: European Journal of Medical Research
J Westhoff, K Weismüller, C Koch, V Mann, M A Weigand, M Henrich
BACKGROUND: Ischemia of intestinal organs is a main cause of complications in surgical intensive care patients. Changes in the tonus of arteries contributing to vascular resistance play an important role in the determination of blood flow and thus oxygen supply of various abdominal organs. It is generally acknowledged that hypoxia itself is able to alter arterial tonus and thus blood flow. METHODS: The present study compared the effects of various degrees of hypoxia on second-order mesenteric arteries from male C57BL/6J mice...
August 25, 2018: European Journal of Medical Research
Bettina Alexandra Buhren, Holger Schrumpf, Edwin Bölke, Kai Kammers, Peter Arne Gerber
BACKGROUND: Hyaluronidase is a hyaluronic acid (HA) metabolizing enzyme, which is approved as an adjuvant for infiltration anesthesia. The "off-label" use of hyaluronidase is regarded as gold standard for the management of HA-filler-associated complications. Yet, up to date there are only few studies that have systematically assessed the degradability of different HA-fillers by hyaluronidase. OBJECTIVE: To analyze the interactions of HA-fillers and hyaluronidase in a time-dependent manner using a novel standardized in vitro approach...
August 20, 2018: European Journal of Medical Research
Kerstin Piayda, Laura Kleinebrecht, Shazia Afzal, Roland Bullens, Iris Ter Horst, Amin Polzin, Verena Veulemans, Lisa Dannenberg, Anna Christina Wimmer, Christian Jung, Florian Bönner, Malte Kelm, Katharina Hellhammer, Tobias Zeus
BACKGROUND: A novel software ("Dynamic Coronary Roadmap") was developed, which offers a real-time, dynamic overlay of the coronary tree on fluoroscopy. Once the roadmap has been automatically generated during angiography it can be used for navigation during percutaneous coronary interventions (PCI). As a feasibility study, we aimed to investigate the feasibility of real-time dynamic coronary roadmapping and consecutive coronary overlay during elective PCI. METHODS AND RESULTS: We studied 936 overlay runs, created following the same amount of angiographies, which were generated during 36 PCIs...
July 31, 2018: European Journal of Medical Research
H Vester, L Schul, F von Matthey, M Beirer, M van Griensven, S Deiler
BACKGROUND: Bony avulsion fractures of the distal phalanges can result in mallet finger deformity if not treated appropriately. Therefore, only minimally displaced fractures can be treated conservatively with a good outcome, as dislocation occurs very often. Several surgical treatment options have been developed during the past decades. Data concerning the recently developed hook plate are promising. So far, no data concerning the subjective satisfaction with this method have been published...
July 20, 2018: European Journal of Medical Research
Ye Gu, Jing Zhao, Li Ao, Jianning Ma, Kena Bao, Min Liu, Weiping Huang
It is reported that glutathione S-transferase mu (GSTM1) polymorphism is associated with non-viral hepatic cirrhosis (HC). However, some studies showed different views. Therefore, in this paper, a meta-analysis was conducted to get a more comprehensive understanding of GSTM1 polymorphisms in non-viral HC susceptibility. The results showed that GSTM1 null was associated with the increased risk of non-viral HC (OR = 1.337, 95% CI 1.112-1.804, p = 0.005). Subgroup analysis of cirrhosis type revealed that GSTM1 null was a prominent risk factor for alcoholic HC (OR = 1...
June 19, 2018: European Journal of Medical Research
Jin-Fang Sun, Hao-Lan Li, Bao-Xia Sun
The original publication of this article [1] contained two erroneous paragraphs related to the time and place for the admission of the pediatric patients with clinically diagnosed severe HFMD. The updated information has been indicated in bold.
June 15, 2018: European Journal of Medical Research
D Pförringer, M Breu, M Crönlein, R Kolisch, K-G Kanz
BACKGROUND: The city of Munich uses web-based information system IVENA to promote exchange of information regarding hospital offerings and closures between the integrated dispatch center and hospitals to support coordination of the emergency medical services. Hospital crowding resulting in closures and thus prolonged transportation time poses a major problem. An innovative discrete agent model simulates the effects of novel policies to reduce closure times and avoid crowding. METHODS: For this analysis, between 2013 and 2017, IVENA data consisting of injury/disease, condition, age, estimated arrival time and assigned hospital or hospital-closure statistics as well as underlying reasons were examined...
June 8, 2018: European Journal of Medical Research
Istvan Marczell, Petra Balogh, Gabor Nyiro, Anna L Kiss, Balazs Kovacs, Gabor Bekesi, Karoly Racz, Attila Patocs
BACKGROUND: Although membrane-associated estrogen receptors (mERs) have been known to play important role in steroid-induced signal transmission, we still know little about their function in the estrogen-induced proliferation of breast cancer cells. METHODS: In our current work we tried to separate membrane-initiated estrogen receptor signaling from the overall estrogenic effect in MCF-7 breast carcinoma cells. Re-analyzing expression data from multiple microarray experiments, we selected a set of key regulatory genes involved in proliferation regulation and estrogen signaling to monitor estrogen-induced transcription changes...
June 7, 2018: European Journal of Medical Research
Patrina S P Poh, Verena Schmauss, Jacqui A McGovern, Daniel Schmauss, Mohit P Chhaya, Peter Foehr, Markus Seeger, Vasilis Ntziachristos, Dietmar W Hutmacher, Martijn van Griensven, Jan-Thorsten Schantz, Elizabeth R Balmayor
BACKGROUND: Capsular contracture is one of the most common complications in surgical interventions for aesthetic breast augmentation or post-mastectomy breast reconstruction involving the use of silicone prostheses. Although the precise cause of capsular contracture is yet unknown, the leading hypothesis is that it is caused by long-term unresolved foreign body reaction towards the silicone breast implant. To authors' best knowledge, this is the first study that elucidates the presence of lysyl oxidase (LOX)-an enzyme that is involved in collagen and elastin crosslinking within fibrous capsules harvested from patients with severe capsular contracture...
June 4, 2018: European Journal of Medical Research
Benjamin Juntermanns, Gernot Maximilian Kaiser, Lena Orth, Henning Reis, Derar Jaradat, Svenja Sydor, Matthias Buechter, Stefan Kasper, Zoltan Mathé, Georgios Charalambos Sotiropoulos, Hideo Andreas Baba, Ali Canbay, Andreas Paul, Christian Dominik Fingas
BACKGROUND: The current seventh edition of the TNM classification for intrahepatic cholangiocarcinoma (ICC) includes tumor number, vascular invasion, lymph node involvement but no longer the tumor size as compared to the sixth edition. The impact of the seventh edition on stage-based prognostic prediction for patients with ICC was evaluated. METHODS: Between 03/2001 and 02/2013, 98 patients with the diagnosis of an ICC were surgically treated at our center. Median survival times were calculated for these patients after separate classification by both sixth and seventh editions...
June 1, 2018: European Journal of Medical Research
Richard M Kwasnicki, George W V Cross, Luke Geoghegan, Zhiqiang Zhang, Peter Reilly, Ara Darzi, Guang Zhong Yang, Roger Emery
BACKGROUND: The prevalence of self-reported shoulder pain in the UK has been estimated at 16%. This has been linked with significant sleep disturbance. It is possible that this relationship is bidirectional, with both symptoms capable of causing the other. Within the field of sleep monitoring, there is a requirement for a mobile and unobtrusive device capable of monitoring sleep posture and quality. This study investigates the feasibility of a wearable sleep system (WSS) in accurately detecting sleeping posture and physical activity...
May 30, 2018: European Journal of Medical Research
Miguel Pishnamaz, Ulrike Schemmann, Christian Herren, Klemens Horst, Frank Hildebrand, Philipp Kobbe, Hans-Christoph Pape
BACKGROUND AND PURPOSE: Posterior stabilization of the spine is associated with iatrogenic muscle damage. This is discussed to represent an important cause of postoperative pain, especially in open reduction and fixation. The aim of this study was to visualize muscular changes after open or percutaneous posterior stabilization of traumatic thoracolumbar spine fractures and to investigate whether or not these changes are related to the clinical outcome. METHODS: This prospective cohort study was performed between 05/2012 and 10/2014...
May 24, 2018: European Journal of Medical Research
Bing-Jian Wang, Jin Geng, Qian-Jun Li, Ting-Ting Hu, Biao Xu, Shu-Ren Ma
OBJECTIVE: This study aims to compare the clinical effects of selective interventional therapy (PCI) under the guidance of fractional flow reserve (FFR) and coronary arteriography. METHODS: Patients with sub-acute ST-segment elevation myocardial infarction (sub-acute STEMI), who were under selective PCI treatment between April 2012 and June 2014, were included into this study. These patients were divided into two groups, based on FFR measurements: FFR-PCI group and radiography-PCI group...
May 24, 2018: European Journal of Medical Research
C Rammos, A Burghardt, J Lortz, O Azizy, R A Jánosi, M Steinmetz, T Rassaf
BACKGROUND: Radial artery access is the primary approach for coronary interventions due to higher safety profile in comparison to femoral access. Radial artery occlusion (RAO) is the main complication of transradial catheterization that can lead to severe symptoms and a permanent artery occlusion. The incidence of RAO after transradial access ranges from 5 to 38% and data regarding treatment is scarce. Whether anticoagulation and vasoactive medication provides an additional benefit in recovery of radial artery patency (RAP) after catheterization has not been investigated in detail...
May 22, 2018: European Journal of Medical Research
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