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European Journal of Medical Research

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https://www.readbyqxmd.com/read/28526089/adipose-derived-mesenchymal-stem-cells-from-liposuction-and-resected-fat-are-feasible-sources-for-regenerative-medicine
#1
Sandra Schneider, Marina Unger, Martijn van Griensven, Elizabeth R Balmayor
BACKGROUND: The use of mesenchymal stem cells (MSCs) in research and in regenerative medicine has progressed. Bone marrow as a source has drawbacks because of subsequent morbidities. An easily accessible and valuable source is adipose tissue. This type of tissue contains a high number of MSCs, and obtaining higher quantities of tissue is more feasible. Fat tissue can be harvested using different methods such as liposuction and resection. First, a detailed isolation protocol with complete characterization is described...
May 19, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28511716/retraction-note-to-inotropic-therapy-for-cardiac-low-output-syndrome-comparison-of-hemodynamic-effects-of-dopamine-dobutamine-versus-dopamine-dopexamine
#2
EDITORIAL
N E El Mokhtari, A Arlt, A Meissner, M Lins
No abstract text is available yet for this article.
May 16, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28431512/hemoglobin-a1c-and-risk-of-left-atrial-thrombus-and-spontaneous-echo-contrast-in-non-valvular-atrial-fibrillation-patients
#3
Rong-Ren Kuang, Fang-Zhou Liu, Yun-Peng Li, Wei-Dong Lin, Hua-Sheng Liang, Ai-Hua Chen
OBJECTIVES: To evaluate the relationship between hemoglobin A1c (HbA1c) and risk of left atrial thrombus/spontaneous echo contrast (LAT/SEC) in non-valvular atrial fibrillation (AF) patients. METHODS: In this retrospective study, 1158 consecutive non-valvular AF patients undergoing transesophageal echocardiography prior to radiofrequency catheter ablation or electric cardioversion were enrolled. Baseline characteristics were collected and analyzed. RESULTS: There were 87 (7...
April 21, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28376859/application-of-transiliac-approach-to-intervertebral-endoscopic-discectomy-in-l5-s1-intervertebral-disc-herniation
#4
Jiayue Bai, Wei Zhang, Yapeng Wang, Jilong An, Jian Zhang, Yapeng Sun, Wenyuan Ding, Yong Shen
OBJECTIVE: To discuss the significance and the short-term effect of bone puncture technique in transiliac approach to intervertebral endoscopic discectomy for the treatment of L5/S1 intervertebral disc herniation. METHODS: Nineteen patients were diagnosed as L5/S1 disc herniation and treated using transiliac approach to endoscopic discectomy (group I), and 20 patients were diagnosed as non-L5/S1 disc herniation and underwent conventional approach (group R). Leg pain was evaluated by VAS...
April 4, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28356163/a-novel-system-for-continuous-real-time-monitoring-of-heart-motion-signals
#5
Guy Dori, Jorge E Schliamser, Oscar Lichtenstein, Ilia Anshelevich, Moshe Y Flugelman
BACKGROUND: Understanding cardiac mechanics is important for developing cardiac therapies. Current modalities for assessing cardiac mechanics sample patient's heart at specific heart rate, contractility, preload, and afterload. The objective of this study was to test the feasibility of a novel system composed of intra-cardiac leads equipped with an inertial module chip (3D accelerometers and 3D gyroscopes) in monitoring continuous heart motion. METHODS: In this descriptive study, four healthy pigs were anesthetized and instrumented with motion-sensitive intra-cardiac leads; the temporal correlation between signals from motion sensors and tissue Doppler from the chest wall were studied; changes in real-time heart accelerations (ACC) and angular velocity (ANGV) were reported as percentages of change from baseline...
March 29, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28351415/role-of-carbonyl-sulfide-in-acute-lung-injury-following-limb-ischemia-reperfusion-in-rats
#6
Yan-Rui Zhao, Wen-Rui Lv, Jun-Lin Zhou
OBJECTIVE: To investigate the effect of carbonyl sulfide (COS) on limb ischemia/reperfusion (I/R)-induced acute lung injury (ALI) and the associated mechanism in rats. METHODS: ALI was induced by bilateral hind limb I/R in Sprague-Dawley (SD) rats. Sixty-four SD rats were randomly divided into the control group, I/R group, I/R + COS group, and I/R + AIR group. We observed the survival rate of the rats and the morphological changes of lung tissues, and we measured the change in the lung coefficient, the expression levels of the intercellular adhesion factor-1 (ICAM-1) protein in lung tissue, the expression of tumor necrosis factor (TNF)-α, interleukin (IL)-lβ, and interleukin (IL)-6 in both lung tissue and serum, and cell apoptosis...
March 28, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28340602/clinical-application-prospect-of-umbilical-cord-derived-mesenchymal-stem-cells-on-clearance-of-advanced-glycation-end-products-through-autophagy-on-diabetic-wound
#7
REVIEW
Yanfu Han, Tianjun Sun, Ran Tao, Yanqing Han, Jing Liu
Nowadays, wound healing delay due to diabetes is considered to be closely related to the accumulation of advanced glycation end products (AGEs). Although mesenchymal stem cells (MSCs) exhibit positive effects on diabetic wound healing, related mechanisms are still not fully elucidated. It has been reported that MSCs can improve the activity of autophagy in injured tissues, thereby playing an important role in wound healing. The autophagy induced by MSCs may be beneficial to diabetic wound healing via removing AGEs, which provide new ideas for clinical treatment of diabetic wounds with the potential of broad application prospects...
March 24, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28327169/the-effect-of-lipoaspirates-vs-dissected-abdominal-fat-on-breast-cancer-cells-in-vitro
#8
Faris Almarzouqi, Hans-Oliver Rennekampff, Jan-Philipp Stromps, Ziyad Alharbi, Norbert Pallua
BACKGROUND: Cancer cells are typically surrounded by stromal cells and embedded in extracellular matrix (ECM). The stromal compartment interacts with cancer cells to promote growth and metastasis. For decades, autologous fasciocutaneous flaps have been safely applied for breast reconstruction after mastectomy. In contrast, the safety of fat grafting (lipofilling) procedure has been under debate regarding the risk of cancer recurrence. METHODS: Harvested fat tissue (lipoaspirates) and dissected abdominal fat (DAF) were co-cultured with MCF-7 breast cancer cells...
March 21, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28292324/v-shaped-double-row-distal-triceps-tendon-repair-a-novel-technique-using-unicortical-button-fixation
#9
Bastian Scheiderer, Lucca Lacheta, Andreas B Imhoff, Sebastian Siebenlist
BACKGROUND: This report was designed to present a novel technique combining suture anchor and unicortical button fixation for distal triceps tendon repair. TECHNICAL DESCRIPTION: For anatomical reinsertion of an acute distal triceps tendon rupture, two suture anchors and one unicortical button forming a V-shaped configuration were used. The operative approach is described in detail. RESULTS: Excellent clinical and functional results were achieved in the early postoperative phase...
March 14, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28274250/prosthetic-joint-infection-development-of-an-evidence-based-diagnostic-algorithm
#10
Heinrich M L Mühlhofer, Florian Pohlig, Karl-Georg Kanz, Ulrich Lenze, Florian Lenze, Andreas Toepfer, Sarah Kelch, Norbert Harrasser, Rüdiger von Eisenhart-Rothe, Johannes Schauwecker
BACKGROUND: Increasing rates of prosthetic joint infection (PJI) have presented challenges for general practitioners, orthopedic surgeons and the health care system in the recent years. The diagnosis of PJI is complex; multiple diagnostic tools are used in the attempt to correctly diagnose PJI. Evidence-based algorithms can help to identify PJI using standardized diagnostic steps. METHODS: We reviewed relevant publications between 1990 and 2015 using a systematic literature search in MEDLINE and PUBMED...
March 9, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28270196/two-cases-of-perivascular-epithelioid-cell-tumor-of-the-uterus-clinical-radiological-and-pathological-diagnostic-challenge
#11
Byung Su Kwon, Dong Soo Suh, Nam Kyung Lee, Yong Jung Song, Kyung Un Choi, Ki Hyung Kim
BACKGROUND: Perivascular epithelioid cell tumor (PEComa) is a rare subtype of mesenchymal origin tumor composed of epithelioid cells which exhibits immunohistochemical co-expressions of melanocytic markers and smooth muscle markers. CASE PRESENTATION: In the first case, malignant uterine PEComa with vaginal and multiple lung metastasis was misdiagnosed preoperatively as uterine leiomyosarcoma despite a preoperative punch biopsy and immunohistochemical analysis of the metastatic vaginal mass...
March 7, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28259167/diagnostic-accuracy-of-arthroscopic-biopsy-in-periprosthetic-infections-of-the-hip
#12
Florian Pohlig, Heinrich M L Mühlhofer, Ulrich Lenze, Florian W Lenze, Christian Suren, Norbert Harrasser, Rüdiger von Eisenhart-Rothe, Johannes Schauwecker
BACKGROUND: Diagnosis of a low-grade periprosthetic joint infection (PJI) prior to revision surgery can be challenging, despite paramount importance for further treatment. Arthroscopic biopsy of synovial and periprosthetic tissue with subsequent microbiological and histological examination can be beneficial but its specific diagnostic value has not been clearly defined. METHODS: 20 consecutive patients who underwent percutaneous synovial fluid aspiration as well as arthroscopic biopsy due to suspected PJI of the hip and subsequent one- or two-stage revision surgery at our institution between January 2012 and May 2015 were enrolled...
March 4, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28196543/the-3-dimensional-miniplate-is-more-effective-than-the-standard-miniplate-for-the-management-of-mandibular-fractures-a-meta-analysis
#13
Yong Liu, Bo Wei, Yuxiang Li, Dawei Gu, Guochao Yin, Bo Wang, Dehui Xu, Xuebing Zhang, Daliang Kong
PURPOSE: The study aimed to determine the superiority between 3-dimensional (3D) miniplate and standard miniplate for mandibular fractures (MFs) treatment. BACKGROUND: Controversial results on the use of standard miniplate and 3D miniplate have remained for management of MFs. METHODS: Several electronic databases were retrieved up to September 2014 to identify eligible studies. The quality of studies was assessed, and the relative risk (RR) with its corresponding 95% confidence interval (CI) was assessed to measure the effect size...
February 14, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28122644/mtb-specific-lymphocyte-responses-are-impaired-in-tuberculosis-patients-with-pulmonary-cavities
#14
Jun Wang, Yaping Dai, Jun Liu, Yongmei Yin, Hao Pei
OBJECTIVE: Tuberculosis (TB), an infectious disease caused by the bacillus Mycobacterium tuberculosis (MTB), is a global health problem. Because the failing immune response in the lung can lead to formation of a pulmonary cavity, this study was designed to clarify MTB-specific lymphocyte responses in TB patients with pulmonary cavities. METHODS: We utilized culture filtrate protein 10 (CFP-10) and early secretory antigenic target 6 (ESAT-6) as immunogenic MTB antigens following overnight stimulation of peripheral blood mononuclear cells (PBMCs)...
January 26, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28115002/left-innominate-vein-stenosis-in-an-asymptomatic-population-a-retrospective-analysis-of-212-cases
#15
Xiangjiang Guo, Yaxue Shi, Hui Xie, Lan Zhang, Guanhua Xue, Leyi Gu, Changning Hao, Shuofei Yang, Kejia Kan
BACKGROUND: Although left innominate vein (LIV) stenosis has been demonstrated to be attributed to compression by adjacent anatomical structures, most of the studies are focusing on hemodialysis patients with clinical symptoms compatible with LIV stenosis. The goal of this study was to retrospectively investigate the incidence of LIV stenosis and its influencing factors in an asymptomatic, non-hemodialysis population, which has rarely been performed. METHODS: From Jan 2013 to Dec 2014, 212 consecutive cases undergoing a chest multi-detector computed tomography (MDCT) angiography were enrolled...
January 23, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28057086/diagnostic-value-of-microrna-143-in-predicting-in-stent-restenosis-for-patients-with-lower-extremity-arterial-occlusive-disease
#16
Zhi-Hai Yu, Hai-Tao Wang, Can Tu
PURPOSE: This study was conducted to explore the diagnostic value of microRNA-143 (miRNA-143) in predicting in-stent restenosis (ISR) of lower extremity arterial occlusive disease (LEAOD). METHODS: From February 2012 to March 2015, 165 patients (112 males and 53 females) with LEAOD undergoing interventional treatment were enrolled in this study. Serum miRNA-143 expression was detected using quantitative real-time polymerase chain reaction (qRT-PCR). Patients were assigned into the restenosis and non-restenosis groups according to routine surveillance postoperative angiography...
January 5, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28049543/the-level-of-free-circulating-mitochondrial-dna-in-blood-as-predictor-of-death-in-case-of-acute-coronary-syndrome
#17
MULTICENTER STUDY
Nikolay P Sudakov, Konstantin A Apartsin, Svetlana A Lepekhova, Sergey B Nikiforov, Alexander I Katyshev, Galina I Lifshits, Anna V Vybivantseva, Yuri M Konstantinov
BACKGROUND: The efficacy of treating acute myocardial ischemic damages depends, to a large extent, on the development of technologies for predicting their course and outcome. The aim of this paper was to explore whether it would be possible to consider the content of free circulating mitochondrial DNA as a danger-associated molecular pattern for assessing the probability of death from myocardial infarction. METHODS: We have analyzed the clinical outcomes based on discharge summaries and autopsy reports obtained in the course of the PROTOCOL observational trial...
January 3, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/27832813/the-need-for-maximal-sterile-barrier-precaution-in-routine-interventional-coronary-procedures-microbiology-analysis
#18
Avi Peretz, Fabio Kuzniec, Diab Ganem, Nabeeh Salman, Dahud Qarawani, Offer Amir
BACKGROUND: Maximal sterile barrier precautions (MSBP) including head coverings and face masks are advocated for use in invasive procedures, including coronary interventions. The rationale for MSBP assumes it is an obligatory measure for infection prevention. However, in many coronary catheterization laboratories, head coverings/face masks are not used in daily practice. This study prospectively evaluated the potential hazards of not routinely using head coverings/face masks in routine coronary interventions...
November 10, 2016: European Journal of Medical Research
https://www.readbyqxmd.com/read/27809933/is-it-time-to-rebalance-the-case-mix-a-portfolio-analysis-of-direct-catheterization-laboratory-costs-over-a-5-year-period
#19
Gunnar Plehn, Thomas Butz, Petra Maagh, Ahmet Oernek, Axel Meissner, Natalie Plehn
BACKGROUND: Cardiac catheterization laboratories (CLL) have continued to function as profit centers for hospitals. Due to a high percentage of material and labor costs, they are natural targets for process improvement. Our study applied a contribution margin (CBM) concept to evaluate costs and cost dynamics over a 5-year period. METHODS: We retrospectively analyzed all procedures performed at a tertiary heart center between 2007 and 2011. Total variable costs, including labor time, material, and maintenance-expenses, were allocated at a global as well as a procedural level...
November 3, 2016: European Journal of Medical Research
https://www.readbyqxmd.com/read/27802829/detection-of-blood-aspiration-in-deadly-head-gunshots-comparing-postmortem-computed-tomography-pmct-and-autopsy
#20
COMPARATIVE STUDY
E Scaparra, O Peschel, C Kirchhoff, M Reiser, S M Kirchhoff
BACKGROUND: The aim of our study was to analyze the reliability of postmortem computed tomography (PMCT) versus autopsy in detecting signs of blood aspiration in a distinct group of patients following deadly head, mouth or floor of mouth gunshot injuries. METHODS: In this study, in 41 cases PMCT was compared to autopsy reports, the gold standard of postmortem exams, regarding detection of blood aspiration. PMCT was evaluated for the presence and level of typical signs of blood aspiration in the major airways and lung using a semi-quantitative scale ranging from level 0 (no aspiration) to 3 (significant aspiration) also taking density values of the described potential aspiratory changes into account...
November 1, 2016: European Journal of Medical Research
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