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European Journal of Medical Research

Hua Qu, Yan-Yan Meng, Hua Chai, Fang Liang, Jia-Yi Zhang, Zhu-Ye Gao, Da-Zhuo Shi
BACKGROUND: The effect of statin treatment on circulating coenzyme Q10 (CoQ10) has been studied in numerous randomized controlled trails (RCTs). However, whether statin treatment decreases circulating CoQ10 is still controversial. METHODS: PubMed, EMBASE, and the Cochrane Library were searched to identify RCTs to investigate the effect of statin treatment on circulating CoQ10. We calculated the pooled standard mean difference (SMD) using a fixed effect model or random effect model to assess the effect of statin treatment on circulating CoQ10...
November 10, 2018: European Journal of Medical Research
D Patschan, N Sugiarto, E Henze, R Mößner, J Mohr, G A Müller, S Patschan
BACKGROUND: Both psoriasis (Ps) and psoriasis arthritis (PsA) have been associated with increased cardiovascular risk. Also, both are characterized by increased neovascularization. Endothelial progenitor cells (EPCs) have been implicated in promoting vascular repair in ischemic diseases. The aim of the study was to correlate the EPC system with CV risk factors and with parameters of vascular stiffness in Ps and PsA. METHODS: Twenty-six healthy subjects, 30 patients with Ps, and 31 patients PsA were included in the study...
November 9, 2018: European Journal of Medical Research
Yuejin Li, Le Xiao, Jinyuan Li, Ping Sun, Lei Shang, Jian Zhang, Quan Zhao, Yiming Ouyang, Linhai Li, Kunmei Gong
OBJECTIVE: The incidence of diabetic atherosclerosis (DA) is increasing worldwide. The study aim was to identify differentially expressed microRNAs (DE-miRs) potentially associated with the initiation and/or progression of DA, thereby yielding new insights into this disease. METHODS: Matched iliac artery tissue samples were isolated from 6 male rats with or without DA. The Affymetrix GeneChip microRNA 4.0 Array was used to detect miRs. Differential expression between atherosclerotic group and non-atherosclerotic group samples was analyzed using the Gene-Cloud of Biotechnology Information platform...
November 3, 2018: European Journal of Medical Research
Henryk Skarżyński, Elżbieta Gos, Danuta Raj-Koziak, Piotr H Skarżyński
BACKGROUND: Many tinnitus scales are available, but all of them have certain limitations. The aim of the current study was to present a psychometric data of a new brief and reliable questionnaire that could be conveniently used for evaluating tinnitus complaint in adults (either with normal or impaired hearing)-Skarzynski Tinnitus Scale (STS). METHODS: The study included 125 participants with at least 1 month of tinnitus duration. All participants were asked to complete the STS, Tinnitus and Hearing Survey (THS), Tinnitus Functional Index (TFI), Tinnitus Handicap Inventory (THI), and Beck Depression Inventory...
November 1, 2018: European Journal of Medical Research
G C Weber, P Firouzi, A M Baran, E Bölke, H Schrumpf, B A Buhren, B Homey, P A Gerber
BACKGROUND: Currently available treatment options for onychomycosis such as topical and systemic antifungals are often of limited efficacy, difficult to administer or associated with relevant side effects. Non-ablative laser therapy is proposed to represent a safe alternative without the disadvantages of drugs. Yet, to date, the efficacy of laser therapy for onychomycosis is discussed controversially. Against this background, we performed a systematic retrospective analysis of our clinical experience of 4 years of onychomycosis treatment applying a long-pulsed 1...
October 24, 2018: European Journal of Medical Research
Ivan Delgado-Enciso, Juan Paz-Garcia, Jose Valtierra-Alvarez, Jorge Preciado-Ramirez, Roman Almeida-Trinidad, Jose Guzman-Esquivel, Martha A Mendoza-Hernandez, Alberto Garcia-Vega, Alejandro D Soriano-Hernandez, Jose L Cortes-Bazan, Hector R Galvan-Salazar, Ariana Cabrera-Licona, Iram P Rodriguez-Sanchez, Margarita L Martinez-Fierro, Josuel Delgado-Enciso, Brenda Paz-Michel
BACKGROUND: A promising novel cell-free bioactive formulation for articular cartilage regeneration, called BIOF2, has recently been tested in pre-clinical trials. The aim of the present study was to evaluate the efficacy and safety of BIOF2 for intra-articular application in patients with severe osteoarthritis of the knee. METHODS: A prospective, randomized, 3-arm, parallel group clinical trial was conducted. It included 24 patients with severe osteoarthritis of the knee (WOMAC score 65...
October 24, 2018: European Journal of Medical Research
Stefan Reers, Georg Karanatsios, Matthias Borowski, Michael Kellner, Michael Reppel, Johannes Waltenberger
BACKGROUND: To assess the frequency of left atrium/left atrial appendage (LA/LAA) thrombus under treatment with non-vitamin K oral anticoagulants (NOACs) in comparison with vitamin K antagonists (VKAs) in patients with non-valvular atrial fibrillation (AF). METHODS: PubMed, Web of Science™, EMBASE and the Cochrane Library databases were searched for studies comparing NOACs with VKAs in AF patients who underwent diagnostic transoesophageal echocardiography (TEE)...
October 23, 2018: European Journal of Medical Research
Azin Jafari, Hanno Matthaei, Vittorio Branchi, Edwin Bölke, Rene H Tolba, Jörg C Kalff, Steffen Manekeller
BACKGROUND: The ever growing demand for liver transplantation inevitably necessitates an expansion of the donor pool. Utilization of "shock organs" is considered suboptimal to date while the associated outcome has hardly been investigated. MATERIALS AND METHODS: Male Wistar rats underwent a period of 30 min of hypovolemic shock. After 24 h livers were explanted and prior to reperfusion underwent either 18 h of cold storage (CS; N = 6) or 17 h of CS followed by 60 min venous systemic oxygen persufflation (VSOP; N = 6)...
October 23, 2018: European Journal of Medical Research
Moritz Crönlein, Lukas Postl, Marc Beirer, Dominik Pförringer, Jennifer Lang, Frederik Greve, Michael Müller, Peter Biberthaler, Chlodwig Kirchhoff
BACKGROUND: The primary goal of this study was to analyse the anatomic configuration of the acromio-clavicular joint in a healthy population to be able to develop a classification in a second step. On the basis of the primary findings a secondary goal was to find potential clinical indications in refer to AC-joint dislocation and lateral clavicle fractures. METHODS: The upper thoracic aperture including both shoulder joints as well as both sterno-clavicular joints was retrospectively reformatted in a bone kernel in axial orientation with 0...
October 23, 2018: European Journal of Medical Research
Feng Zhang, Qingjing Feng, Zhiyong Zhang, Yanjun Hu, Zhifeng Zhang
OBJECTIVE: The objective of this study was to compare the performance of screening mammography versus magnetic resonance imaging (MRI) in hormone replacement therapy (HRT) users. METHODS: We performed a retrospective review of 4628 women who had mammography or breast MRI screening from the beginning of HRT use at three institutions from April 2005 to December 2015. Information of demographics, number of biopsies performed and pathologic outcomes were collected. Sensitivity, specificity, negative predictive value (NPV) and positive predictive value (PPV) of screening mammography and MRI were compared...
October 20, 2018: European Journal of Medical Research
Weiming Hao, Xia Xu, Haifeng Shi, Chiyu Zhang, Xiaoxiang Chen
BACKGROUND: Many studies have demonstrated that the genetic variants of tumor suppressor gene TP53 contribute to the prediction of breast cancer risk. However, most of them focused on Europeans and Americans; the investigations about Asians, especially Chinese women, are scarce. Thus, the aim of this study was to explore the influence of TP53 codon 72 and intron 3 16-bp duplication polymorphisms on the breast cancer risk in Chinese women, especially those from eastern China. METHODS: Blood samples collected from 254 breast cancer patients and 252 healthy female individuals were investigated...
October 11, 2018: European Journal of Medical Research
Frederik Greve, Karl Friedrich Braun, Veronika Vitzthum, Michael Zyskowski, Michael Müller, Chlodwig Kirchhoff, Peter Biberthaler, Marc Beirer
BACKGROUND: There are many approved patient-related outcome measurement tools regarding ankle pathologies. However, there is none incorporating the range of motion (ROM) as an objective parameter. Most instruments focus on subjective parameters such as pain and impairment at work or daily living. Furthermore, the majority is only applicable to a specific pathology. Therefore, the objective of our study was to develop and validate the Munich Ankle Questionnaire (MAQ) as a universal self-assessment score including subjective and objective items...
September 28, 2018: European Journal of Medical Research
Stephan Alexander Braun, Julia Baran, Holger Schrumpf, Bettina Alexandra Buhren, Edwin Bölke, Bernhard Homey, Peter Arne Gerber
BACKGROUND: Ingenol mebutat (IM)-gel is effective for the topical treatment of epithelial tumors, including actinic keratoses (AKs) or anogenital warts (AGW). AK patients treated with IM develop intensified inflammatory reactions on sights of prior clinical visible or palpable AKs as compared to the surrounding actinically damaged skin, suggesting the induction of a tumor cell-directed inflammation. AGW patients treated with IM develop even stronger inflammatory reactions with large erosions, suggesting a directed inflammatory response against HPV-infected keratinocytes...
September 28, 2018: European Journal of Medical Research
J Nowotny, B El-Zayat, J Goronzy, A Biewener, F Bausenhart, S Greiner, P Kasten
BACKGROUND: In the treatment of lateral epicondylitis (LE), the role of a new dynamic wrist orthosis is unclear. PATIENTS AND METHODS: Patients suffering from a LE longer than 3 months were multicentrically and prospectively randomized into a physiotherapeutic group (PT group) and in a physiotherapy group plus wrist orthosis (PT + O group). Physiotherapy consisted of daily eccentric strengthening exercises under initial professional supervision. Inclusion criteria were a Placzek score greater than 4...
September 15, 2018: European Journal of Medical Research
Lukas Kurt Postl, Viktoria Bogner, Martijn van Griensven, Marc Beirer, Karl Georg Kanz, Christoph Egginger, Peter Biberthaler, Chlodwig Kirchhoff
BACKGROUND: Data on PNM elastase levels in cerebrospinal fluid following traumatic brain injury (TBI) in humans are not available in the literature. Therefore, the aim of this prospective study was to evaluate the dynamics of PMN elastase in the cerebrospinal fluid (CSF) of patients after TBI. METHODS: Patients suffering from isolated, closed TBI, presenting with an initial Glasgow coma score ≤ 8 and with intracerebral hemorrhage on the initial cranial computed tomography scan (performed within 90 min after TBI) were enrolled...
September 15, 2018: European Journal of Medical Research
Jörg Nowotny, Sebastian Löbstein, Achim Biewener, Guido Fitze, Philip Kasten
BACKGROUND: Chondral or osteochondral lesions, post-traumatic contracture and loose bodies of the elbow are often associated with chronic pain, stiffness, repetitive swelling and joint blockages. Therefore, arthroscopy of the elbow is often used in the elderly for the treatment of osteochondral defects or arthrolysis. There are only a few reports and studies about arthroscopic therapy of the elbow in children and adolescents. This study assesses the clinical outcome of arthroscopic therapy in this age group...
September 15, 2018: European Journal of Medical Research
Hong-Wei Chen, Xiao-Feng Teng
BACKGROUND: The coracoid process plays an important role in maintaining the stability of the elbow joint. A fracture of the coronoid process is often treated via surgical approaches, including open reduction and internal fixation, which aim to regain a stable, flexible, and loadable joint. In this study, we compared the anterior, medial, and posterior approaches of internal fixation in the repair of fractures of the coronoid process of the ulna. METHODS: In this retrospective study, 147 patients with fractures in the coronoid process of the ulna were recruited and classified into the anterior group (n = 73), the medial group (n = 32), and the posterior group (n = 42) according to the surgical approach used for internal fixation...
September 11, 2018: European Journal of Medical Research
Fatma Celik, Ipek S Edipoglu
BACKGROUND: Preoperative anxiety is one of the most important problems for the patients, because it causes emotional and psychiatric problems as well as physical problems. It is crucial to detect the patient's existing anxiety to assist patients. Our primary aim in this study is to investigate how the patient's age, gender, the operation, surgical briefing, type of anesthesia recommended for the operation ahead, and patient's prior anesthesia experience affect the patient's anxieties...
September 11, 2018: European Journal of Medical Research
Benedikt Peterburs, Anke Mittelstaedt, Philipp Haas, Maximilian Petri, Ralf Westphal, Christian Dullin, Stephan Sehmisch, Claudia Neunaber
BACKGROUND: Reduction of femoral shaft fractures remains a challenging problem in orthopaedic surgery. Robot-assisted reduction might ease reduction and fracture treatment. However, the influence of different reduction pathways on patients' physiology is not fully known yet. Therefore, the aim of this study was to examine the biomechanics and histology of fracture healing after direct and prolonged robot-assisted reduction in an in vivo rat model. METHODS: 144 male CD® rats were randomly assigned to 12 groups...
September 4, 2018: European Journal of Medical Research
J Westhoff, K Weismüller, C Koch, V Mann, M A Weigand, M Henrich
BACKGROUND: Ischemia of intestinal organs is a main cause of complications in surgical intensive care patients. Changes in the tonus of arteries contributing to vascular resistance play an important role in the determination of blood flow and thus oxygen supply of various abdominal organs. It is generally acknowledged that hypoxia itself is able to alter arterial tonus and thus blood flow. METHODS: The present study compared the effects of various degrees of hypoxia on second-order mesenteric arteries from male C57BL/6J mice...
August 25, 2018: European Journal of Medical Research
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