We have located links that may give you full text access.
Properties of [ 18 F]FAPI monitoring of acute radiation pneumonia versus [ 18 F]FDG in mouse models.
Annals of Nuclear Medicine 2024 Februrary 27
OBJECTIVE: In this study, the uptake characteristics of [18 F]fibroblast activation protein inhibitor (FAPI) molecular imaging probe were investigated in acute radiation pneumonia and lung cancer xenografted mice before and after radiation to assess the future applicability of [18 F]FAPI positron emission tomography/computed tomography (PET/CT) imaging in early radiotherapy response.
METHODS: Initially, the biodistribution of [18 F]FAPI tracer in vivo were studied in healthy mice at each time-point. A comparison of [18 F]FAPI and [18 F]fluorodeoxyglucose (FDG) PET/CT imaging efficacy in normal ICR, LLC tumor-bearing mice was evaluated. A radiation pneumonia model was then investigated using a gamma counter, small animal PET/CT, and autoradiography. The uptake properties of [18 F]FAPI in lung cancer and acute radiation pneumonia were investigated using autoradiography and PET/CT imaging in mice.
RESULTS: The tumor area was visible in [18 F]FAPI imaging and the tracer was swiftly eliminated from normal tissues and organs. There was a significant increase of [18 F]FDG absorption in lung tissue after radiotherapy compared to before radiotherapy, but no significant difference of [18 F]FAPI uptake under the same condition. Furthermore, both the LLC tumor volume and the expression of FAP-ɑ decreased after thorax irradiation. Correspondingly, there was no notable [18 F]FAPI uptake after irradiation, but there was an increase of [18 F]FDG uptake in malignancies and lungs.
CONCLUSIONS: The background uptake of [18 F]FAPI is negligible. Moreover, the uptake of [18 F]FAPI may not be affected by acute radiation pneumonitis compared to [18 F]FDG, which may be used to more accurately evaluate early radiotherapy response of lung cancer with acute radiation pneumonia.
METHODS: Initially, the biodistribution of [18 F]FAPI tracer in vivo were studied in healthy mice at each time-point. A comparison of [18 F]FAPI and [18 F]fluorodeoxyglucose (FDG) PET/CT imaging efficacy in normal ICR, LLC tumor-bearing mice was evaluated. A radiation pneumonia model was then investigated using a gamma counter, small animal PET/CT, and autoradiography. The uptake properties of [18 F]FAPI in lung cancer and acute radiation pneumonia were investigated using autoradiography and PET/CT imaging in mice.
RESULTS: The tumor area was visible in [18 F]FAPI imaging and the tracer was swiftly eliminated from normal tissues and organs. There was a significant increase of [18 F]FDG absorption in lung tissue after radiotherapy compared to before radiotherapy, but no significant difference of [18 F]FAPI uptake under the same condition. Furthermore, both the LLC tumor volume and the expression of FAP-ɑ decreased after thorax irradiation. Correspondingly, there was no notable [18 F]FAPI uptake after irradiation, but there was an increase of [18 F]FDG uptake in malignancies and lungs.
CONCLUSIONS: The background uptake of [18 F]FAPI is negligible. Moreover, the uptake of [18 F]FAPI may not be affected by acute radiation pneumonitis compared to [18 F]FDG, which may be used to more accurately evaluate early radiotherapy response of lung cancer with acute radiation pneumonia.
Full text links
Related Resources
Trending Papers
Consensus Statement on Vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows.Endocrine Reviews 2024 April 28
The Tricuspid Valve: A Review of Pathology, Imaging, and Current Treatment Options: A Scientific Statement From the American Heart Association.Circulation 2024 April 26
Intravenous infusion of dexmedetomidine during the surgery to prevent postoperative delirium and postoperative cognitive dysfunction undergoing non-cardiac surgery: a meta-analysis of randomized controlled trials.European Journal of Medical Research 2024 April 19
Interstitial Lung Disease: A Review.JAMA 2024 April 23
Ventilator Waveforms May Give Clues to Expiratory Muscle Activity.American Journal of Respiratory and Critical Care Medicine 2024 April 25
Acute Kidney Injury and Electrolyte Imbalances Caused by Dapagliflozin Short-Term Use.Pharmaceuticals 2024 March 27
Systemic lupus erythematosus.Lancet 2024 April 18
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app