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Annals of Nuclear Medicine

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https://www.readbyqxmd.com/read/27921286/-18-f-fdg-pet-ct-to-differentiate-malignant-necrotic-lymph-node-from-benign-cystic-lesions-in-the-neck
#1
Peymaneh Abadi, Allan Johansen, Christian Godballe, Oke Gerke, Poul Flemming Høilund-Carlsen, Anders Thomassen
OBJECTIVE: Patients presenting with cystic lesions in the neck without obvious signs of malignancy constitute a diagnostic challenge since fine needle aspiration is often insufficient and a diagnosis may not be reached until surgical resection/biopsy is performed. The differential diagnosis of a cystic cervical mass comprises a variety of benign conditions, but malignancy must be ruled out. We examined the diagnostic performance of fluorine-18 fluorodeoxyglucose ((18)F-FDG) PET/CT to identify malignancy...
December 5, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27921285/spatiotemporal-distribution-modeling-of-pet-tracer-uptake-in-solid-tumors
#2
Madjid Soltani, Mostafa Sefidgar, Hossein Bazmara, Michael E Casey, Rathan M Subramaniam, Richard L Wahl, Arman Rahmim
OBJECTIVE: Distribution of PET tracer uptake is elaborately modeled via a general equation used for solute transport modeling. This model can be used to incorporate various transport parameters of a solid tumor such as hydraulic conductivity of the microvessel wall, transvascular permeability as well as interstitial space parameters. This is especially significant because tracer delivery and drug delivery to solid tumors are determined by similar underlying tumor transport phenomena, and quantifying the former can enable enhanced prediction of the latter...
December 5, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27914043/a-revisit-to-quantitative-pet-with-18-f-fdopa-of-high-specific-activity-using-a-high-resolution-condition-in-view-of-application-to-regenerative-therapy
#3
Go Akamatsu, Akihito Ohnishi, Kazuki Aita, Hiroyuki Nishida, Yasuhiko Ikari, Masahiro Sasaki, Nobuo Kohara, Michio Senda
OBJECTIVE: With the advent of regenerative/cell therapy for Parkinson's disease (PD), (18)F-FDOPA has drawn new attention as a biomarker of the therapeutic that cannot be evaluated with radiopharmaceuticals for dopamine transporter. Since most previous (18)F-FDOPA PET studies were carried out many years ago with a PET scanner of lower resolution and with (18)F-FDOPA of low specific activity synthesized from (18)F-F2, we used a newer PET/CT scanner with a high-resolution condition and (18)F-FDOPA synthesized from (18)F-F(-) to re-evaluate this technique on normal subjects and patients with PD, together with D2 receptor imaging with (11)C-raclopride (RAC)...
December 2, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27885545/optimization-of-scan-initiation-timing-after-11-c-methionine-administration-for-the-diagnosis-of-suspected-recurrent-brain-tumors
#4
Reiko Nakajima, Koichiro Abe, Mitsuru Momose, Kenji Fukushima, Yuka Matsuo, Ken Kimura, Chisato Kondo, Shuji Sakai
OBJECTIVE: (11)C-Methionine (MET) positron emission tomography (PET) imaging is a valuable technique for the evaluation of primary and recurrent brain tumors. Many studies have used MET-PET for data acquisition starting at 20 min after the tracer injection, while others have used scan initiation times at 5-15 min postinjection. No previous studies have identified the best acquisition timing during MET-PET imaging for suspected recurrent brain tumors. Here we sought to determine the optimal scan initiating timing after MET administration for the detection of recurrent brain tumors...
November 24, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27848160/coronary-flow-reserve-and-relative-flow-reserve-measured-by-n-13-ammonia-pet-for-characterization-of-coronary-artery-disease
#5
Sang-Geon Cho, Ki Seong Park, Jahae Kim, Sae-Ryung Kang, Ho-Chun Song, Ju Han Kim, Jae Yeong Cho, Young Joon Hong, Zeenat Jabin, Hee Jeong Park, Geum-Cheol Jeong, Seong Young Kwon, Jin Chul Paeng, Hyeon Sik Kim, Jung-Joon Min, Ernest V Garcia, Henry Hee-Seung Bom
OBJECTIVE: We evaluated the relationships between coronary flow reserve (CFR) and relative flow reserve (RFR) measured by N-13 ammonia positron emission tomography (PET) for characterization of epicardial coronary artery disease (CAD). METHODS: Sixty-nine consecutive stable angina patients underwent N-13 ammonia PET, coronary computed tomography angiography (CCTA), and if necessary, invasive coronary angiography (CAG) within 2 weeks. Myocardial blood flow (MBF), CFR, RFR, and coronary vascular resistance of the reference arterial territory (CVRref) were measured by N-13 ammonia PET...
November 15, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27848159/effect-of-chemotherapy-on-the-impact-of-fdg-pet-ct-in-selection-of-patients-for-surgical-resection-of-colorectal-liver-metastases-single-center-analysis-of-pet-cam-randomized-trial
#6
Ur Metser, Jaydeep Halankar, Deanna Langer, Ravi Mohan, Douglas Hussey, Moshonov Hadas, Shlomit Tamir
: The largest randomized controlled trial (RCT) on the effect of FDG-PET on surgical management for metastatic colorectal adenocarcinoma to liver ("PET-CAM") reported only a modest change in surgical management (8%). PURPOSE: To explore the relationship between prior chemotherapy and detection of metastatic disease on PET in patients from PET-CAM. Secondary aim: to determine whether centralized imaging interpretation could have impacted trial results. METHODS: The study included 120 patients from a single institution...
November 15, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27815812/sentinel-node-mapping-in-endometrial-cancer-patients-comparing-spect-ct-gamma-probe-and-dye
#7
Federica Elisei, Cinzia Crivellaro, Daniela Giuliani, Carlotta Dolci, Elena De Ponti, Luca Montanelli, Maria La Manna, Luca Guerra, Maurizio Arosio, Claudio Landoni, Alessandro Buda
OBJECTIVE: The aim of this study was to compare preoperative SPECT/CT with gamma-probe and methylene blue-dye (MBD) in the identification of sentinel lymph node (SLN) in early stage endometrial cancer. METHODS: 40 stage-I EC patients (66.7 ± 9.7 years) underwent preoperative lymphoscintigraphy. After about 3 h from Tc-99m-albumin nanocolloid cervical injection, all patients underwent SPECT/CT study. MBD was injected into the cervix just before surgery under general anesthesia...
November 4, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27812791/generating-harmonized-suv-within-the-eanm-earl-accreditation-program-software-approach-versus-earl-compliant-reconstruction
#8
Charline Lasnon, Thibault Salomon, Cédric Desmonts, Pascal Dô, Youssef Oulkhouir, Jeannick Madelaine, Nicolas Aide
BACKGROUND: Evolutions in hardware and software PET technology, such as point spread function (PSF) reconstruction, have been shown to improve diagnostic performance, but can also lead to important device-dependent and reconstruction-dependent variations in standardized uptake values (SUVs). This may preclude the multicentre use of SUVs as a prognostic or diagnostic tool or as a biomarker of the early response to antineoplastic treatments. This study compared two SUV harmonization strategies using a newer reconstruction algorithm that improves lesion detection while maintaining comparability with older systems: (1) the use of a second reconstruction compliant with harmonization standards and (2) the use of a proprietary software tool (EQ...
November 3, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27804054/regional-myocardial-damage-and-active-inflammation-in-patients-with-cardiac-sarcoidosis-detected-by-non-invasive-multi-modal-imaging
#9
Shohei Kataoka, Mitsuru Momose, Kenji Fukushima, Naoki Serizawa, Atsushi Suzuki, Chisato Kondo, Koichiro Abe, Shuji Sakai, Nobuhisa Hagiwara
AIMS: Cardiac sarcoidosis (CS) can be diagnosed using (18)F-FDG-PET/CT (PET), cardiovascular magnetic resonance (CMR), and (123)I-BMIPP/(201)TlCl dual myocardial SPECT. This study aims to clarify the relationships among the three modalities with respect to CS. METHODS AND RESULTS: We evaluated 16 patients (male n = 11; age 55 ± 13 years) with confirmed CS who underwent PET, CMR, and dual SPECT with gated SPECT before starting steroid therapy. The left ventricular myocardium was divided into 17 segments to obtain SUVmax for PET images, defect scores from 0 to 4 (0 normal; 4 absent), and mismatch scores for dual SPECT (BMDS, TLDS, and MS) images and late gadolinium enhancement (LGE) scores (0 none; 1 partly positive; 2 homogeneous) on CMR images...
November 1, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27757803/low-and-high-dose-radioiodine-therapy-for-low-intermediate-risk-differentiated-thyroid-cancer-a-preliminary-clinical-trial
#10
Yuan Qu, Rui Huang, Lin Li
OBJECTIVES: To compare the ablation results, therapeutic responses and adverse reactions between a low dose (1.1 GBq) or high dose (3.7 GBq) of (131)I in low-/intermediate-risk differentiated thyroid cancer (DTC) patients. The factors influencing the ablation result and therapeutic response were also analyzed. METHODS: The researchers used a random number table to randomly assign the enrolled patients to the low-dose group or high-dose group at a 1:1 ratio, and assessment of ablation result, therapeutic response, and adverse reactions evaluated 6 ± 3 months after therapy...
October 18, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27744544/determination-of-radionuclides-and-radiochemical-impurities-produced-by-in-house-cyclotron-irradiation-and-subsequent-radiosynthesis-of-pet-tracers
#11
Kiichi Ishiwata, Kunpei Hayashi, Masanari Sakai, Sugio Kawauchi, Hideaki Hasegawa, Jun Toyohara
OBJECTIVE: To elucidate the radionuclides and radiochemical impurities included in radiosynthesis processes of positron emission tomography (PET) tracers. METHODS: Target materials and PET tracers were produced using a cyclotron/synthesis system from Sumitomo Heavy Industry. Positron and γ-ray emitting radionuclides were quantified by measuring radioactivity decay and using the high-purity Ge detector, respectively. Radiochemical species in gaseous and aqueous target materials were analyzed by gas and ion chromatography, respectively...
October 15, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27686469/intratumoral-heterogeneity-of-18-f-flt-uptake-predicts-proliferation-and-survival-in-patients-with-newly-diagnosed-gliomas
#12
Katsuya Mitamura, Yuka Yamamoto, Nobuyuki Kudomi, Yukito Maeda, Takashi Norikane, Keisuke Miyake, Yoshihiro Nishiyama
BACKGROUND: The nucleoside analog 3'-deoxy-3'-(18)F-fluorothymidine (FLT) has been investigated for evaluating tumor proliferating activity in brain tumors. We evaluated FLT uptake heterogeneity using textural features from the histogram analysis in patients with newly diagnosed gliomas and examined correlation of the results with proliferative activity and patient prognosis, in comparison with the conventional PET parameters. METHODS: FLT PET was investigated in 37 patients with newly diagnosed gliomas...
September 29, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27686468/diagnostic-utility-of-a-computer-aided-diagnosis-system-for-whole-body-bone-scintigraphy-to-detect-bone-metastasis-in-breast-cancer-patients
#13
Misugi Urano, Yumi Maki, Hiroko Nishikawa, Tatsuya Kawai, Norio Shiraki, Yuta Shibamoto
OBJECTIVE: To compare the diagnostic ability of planar images (PI) and images obtained by a computer-aided diagnosis (CAD) system (Viewer for Standardized Bone Scintigraphies; VSBONE) of whole-body bone scintigraphy for detecting bone metastases in breast cancer patients. METHODS: 81 women (median: 56 years; range: 32-79) with a history of breast cancer were included in this study. They underwent whole-body bone scintigraphy after intravenous injection of 740 MBq technetium-99m hydroxymethylene diphosphonate...
September 29, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27680022/synthesis-and-basic-evaluation-of-7%C3%AE-3-18-f-fluoropropyl-testosterone-and-7%C3%AE-3-18-f-fluoropropyl-dihydrotestosterone
#14
Mayumi Okamoto, Kyosuke Naka, Kiichi Ishiwata, Isao Shimizu, Jun Toyohara
OBJECTIVE: 7α-Substituted androgen derivatives may have the potential to visualize androgen receptors with positron emission tomography. In the present study, we synthesized fluoropropyl derivatives of 7α-(3-[(18)F]fluoropropyl)-testosterone ([(18)F]7) and 7α-(3-[(18)F]fluoropropyl)-dihydrotestosterone ([(18)F]15), and characterized their in vitro binding, in vivo biodistribution, and performed blocking studies in mature androgen deprived male rats. METHODS: We synthesized [(18)F]7 and [(18)F]15...
September 28, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27680021/mr-guided-attenuation-map-for-prostate-pet-mri-an-intensity-and-morphologic-based-segmentation-approach-for-generating-a-five-class-attenuation-map-in-pelvic-region
#15
M Shirin Shandiz, H Saligheh Rad, P Ghafarian, M Bakhshayesh Karam, Afshin Akbarzadeh, Mohammad Reza Ay
PURPOSE: Prostate imaging is one of the major application of hybrid PET/MRI systems. Inaccurate attenuation maps (µ-maps) derived by direct segmentation (SEG) in which the cortical bone is ignored and the volume of the air in cavities is underestimated is the main challenge of commercial PET/MRI systems for the quantitative analysis of the pelvic region. The present study considered the cortical bone and air cavity along with soft tissue, fat, and background air in the µ-map of the pelvic region using a method based on SEG...
September 28, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27679399/influence-of-volumetric-4-methyl-11-c-thiothymidine-pet-ct-parameters-for-prediction-of-the-clinical-outcome-of-head-and-neck-cancer-patients
#16
Hiroshi Hoshikawa, Terushige Mori, Yukito Maeda, Satoshi Takahashi, Yohei Ouchi, Yuka Yamamoto, Yoshihiro Nishiyama
OBJECTIVE: This prospective study compared the value of pretreatment 4'-[methyl-(11)C]-thiothymidine ((11)C-4DST) volumetric parameters and those of 2-deoxy-2-[18F] fluoro-D-glucose ((18)F-FDG) in predicting the clinical outcome in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: Fifty patients with HNSCC underwent (11)C-4DST PET/CT and (18)F-FDG PET/CT prior to anticancer therapy. (18)F-FDG metabolic tumor volume ((18)F-FDG MTV) and total lesion glycolysis (TLG) were calculated from (18)F-FDG PET, and (11)C-4DST MTV and total lesion proliferation (TLP) were calculated from (11)C-4DST PET...
September 27, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27663442/correlation-of-hif-1%C3%AE-hif-2%C3%AE-expression-with-fdg-uptake-in-lung-adenocarcinoma
#17
Kotaro Higashi, Toshiaki Yamagishi, Yoshimichi Ueda, Yasuhito Ishigaki, Miyako Shimasaki, Yuka Nakamura, Manabu Oguchi, Tsutomu Takegami, Motoyasu Sagawa, Hisao Tonami
OBJECTIVES: Hypoxia is a key element involved in the development and progression of tumors. HIF-1α may transiently induce and mediate the response to acute and severe hypoxia, while HIF-2α may induce a longer response and may control the response to chronic and moderate hypoxia. Hypoxia increases the cellular uptake of FDG. Therefore, HIF may play an important role in the process of the cellular uptake of FDG. The aim of this study was to compare HIF-1α/HIF-2α expression with FDG uptake, Glut-1 expression, and prognosis in the patients with lung adenocarcinoma and to investigate the role of HIF-1α/HIF-2α in the uptake of FDG in lung adenocarcinoma...
September 23, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27645144/prognostic-value-of-primary-tumor-suvmax-on-f-18-fdg-pet-ct-compared-with-semi-quantitative-tumor-uptake-on-tc-99m-sestamibi-breast-specific-gamma-imaging-in-invasive-ductal-breast-cancer
#18
Jang Yoo, Hai-Jeon Yoon, Bom Sahn Kim
OBJECTIVE: This study aimed to evaluate the prognostic value of F-18 FDG PET/CT in comparison with Tc-99m sestamibi breast-specific gamma imaging (BSGI) and previously established clinical prognostic parameters of invasive ductal breast carcinoma (IDC). METHODS: We retrospectively included 157 female IDC patients (mean age 49.2 years, range 29.9-78.9) who underwent PET/CT and BSGI. The maximum standardized uptake value (SUVmax) and tumor to normal background ratios (TNRs) of their primary tumors were measured on PET/CT and BSGI, respectively...
September 19, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27637179/one-year-of-nuclear-cardiology-in-europe
#19
Olivier Lairez, Denis Agostini
No abstract text is available yet for this article.
September 16, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27637178/new-section-in-ejnmmi-and-annals-of-nuclear-medicine
#20
Ignasi Carrió, Seigo Kinuya
No abstract text is available yet for this article.
September 16, 2016: Annals of Nuclear Medicine
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