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Annals of Nuclear Medicine

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https://www.readbyqxmd.com/read/28547521/validation-of-the-cingulate-island-sign-with-optimized-ratios-for-discriminating-dementia-with-lewy-bodies-from-alzheimer-s-disease-using-brain-perfusion-spect
#1
Etsuko Imabayashi, Tsutomu Soma, Daichi Sone, Tadashi Tsukamoto, Yukio Kimura, Noriko Sato, Miho Murata, Hiroshi Matsuda
OBJECTIVE: Dementia with Lewy bodies (DLB) is often cited as the second most common dementia after Alzheimer's disease (AD). It is clinically important to distinguish DLB from AD because specific side effects of antipsychotic drugs are limited to DLB. The relative preservation of cingulate glucose metabolism in the posterior cingulate gyri versus that in the precuni, known as the cingulate island sign (CIS), in patients with DLB compared with AD is supposed to be highly specific for diagnosing DLB...
May 25, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28516335/prognostic-value-of-pre-treatment-18-f-fdg-pet-uptake-in-small-cell-lung-cancer
#2
Meryem Aktan, Mehmet Koc, Gul Kanyilmaz, Berrin Benli Yavuz
PURPOSE: Small-cell lung cancer (SCLC) is an aggressive disease, despite an initially favorable response to treatment, and its prognosis is still poor. Multiple parameters have been studied as possible prognostic factors, but none of them are reliable enough to change the treatment approach. (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET) is a novel imaging technique for staging of SCLC. The aim of this study was to evaluate the prognostic value of pre-treatment FDG-PET parameters on clinical outcome in limited stage (LS) SCLC patients treated with curative thoracic radiotherapy (RT) and chemotherapy...
May 17, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28497430/erratum-to-comparative-evaluation-of-the-algorithms-for-parametric-mapping-of-the-novel-myocardial-pet-imaging-agent-18-f-fptp
#3
Ji Who Kim, Seongho Seo, Hyeon Sik Kim, Dong-Yeon Kim, Ho-Young Lee, Keon Wook Kang, Dong Soo Lee, Hee-Seung Bom, Jung-Joon Min, Jae Sung Lee
No abstract text is available yet for this article.
May 11, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28497429/pathogenesis-and-fdg-pet-ct-findings-of-epstein-barr-virus-related-lymphoid-neoplasms
#4
REVIEW
Akira Toriihara, Reiko Nakajima, Ayako Arai, Masashi Nakadate, Koichiro Abe, Kazunori Kubota, Ukihide Tateishi
Epstein-Barr virus (EBV) is one of the most common viruses, infecting more than 90% of the adult population worldwide. EBV genome is detected in some lymphoid neoplasms. Not only their histopathological subtypes, but also their backgrounds and their clinical courses are variable. A number of B-cell lymphoproliferative disorders associated with the immunocompromised state are related to EBV infection. The incidences of these disorders have been increasing along with generalization of organ transplantations and use of immunosuppressive treatments...
May 11, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28474165/evaluation-of-99m-tc-3prgd2-integrin-receptor-imaging-in-hepatocellular-carcinoma-tumour-bearing-mice-comparison-with-18-f-fdg-metabolic-imaging
#5
Jieling Zheng, Weibing Miao, Chao Huang, Haoxue Lin
OBJECTIVE: Our study was designed to explore the utility of (99m)Tc-HYNIC-PEG4-E[PEG4-c(RGDfK)]2 ((99m)Tc-3PRGD2) for the detection of hepatocellular carcinoma (HCC) and specifically to compare the diagnostic performance of (99m)Tc-3PRGD2 integrin receptor imaging and 2-18-fluoro-2-deoxy-D-glucose ((18)F-FDG) metabolic imaging in a nude mouse model. METHODS: (99m)Tc-3PRGD2 was synthesized using a HYNIC-3PRGD2 lyophilized kit with (99m)TcO4 labelling. The nude mouse animal model was established by subcutaneously injecting 5 × 10(7)/ml HepG2 cells into the shoulder flank of each mouse...
May 4, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28470631/fdg-pet-ct-predicts-survival-and-lung-metastasis-of-hypopharyngeal-cancer-in-a-multi-institutional-retrospective-study
#6
Hidenori Suzuki, Katsuhiko Kato, Masami Nishio, Tsuneo Tamaki, Yasushi Fujimoto, Mariko Hiramatsu, Nobuhiro Hanai, Takeshi Kodaira, Yoshiyuki Itoh, Shinji Naganawa, Michihiko Sone, Yasuhisa Hasegawa
OBJECTIVES: We investigated a possible correlation between the maximum standardized uptake value (SUVmax), which is assessed by pretreatment (18)F-fluorodeoxyglucose positron emission tomography with computed tomography, and the overall survival (OS) in patients with hypopharyngeal squamous cell carcinoma from two institutions on long-term follow-up, and examined whether SUVmax is correlated with several survival outcomes, including lung metastasis-free survival. METHODS: A total of 81 patients were enrolled...
May 3, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28470630/characteristics-of-single-and-dual-photopeak-energy-window-acquisitions-with-thallium-201-iq-spect-ct-system
#7
Takayuki Shibutani, Masahisa Onoguchi, Hiroto Yoneyama, Takahiro Konishi, Shinro Matsuo, Kenichi Nakajima, Seigo Kinuya
OBJECTIVES: Although dual-energy (DE) acquisition with conventional (201)Tl myocardial perfusion SPECT has several advantages such as improved attenuation of the inferior wall and increased acquisition counts, the characteristics of IQ-SPECT have not been fully evaluated. We evaluate the difference of characteristics between single-energy (SE) and dual-energy (DE) imaging using (201)Tl myocardial IQ-SPECT. METHODS: Two myocardial phantoms were created simulating normal myocardium and infarction of the inferior wall...
May 3, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28456877/diagnostic-performance-of-a-computer-assisted-diagnosis-system-for-bone-scintigraphy-of-newly-developed-skeletal-metastasis-in-prostate-cancer-patients-search-for-low-sensitivity-subgroups
#8
Mitsuru Koizumi, Kazuki Motegi, Masamichi Koyama, Takashi Terauchi, Takeshi Yuasa, Junji Yonese
PURPOSE: The computer-assisted diagnostic system for bone scintigraphy (BS) BONENAVI is used to evaluate skeletal metastasis. We investigated its diagnostic performance in prostate cancer patients with and without skeletal metastasis and searched for the problems. METHODS: An artificial neural network (ANN) value was calculated in 226 prostate cancer patients (124 with skeletal metastasis and 101 without) using BS. Receiver operating characteristic curve analysis was performed and the sensitivity and specificity determined (cutoff ANN = 0...
April 29, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28451991/-18-f-fp-dtbz-pet-study-in-a-lactacystin-treated-rat-model-of-parkinson-disease
#9
Chi-Chang Weng, Siao-Lan Huang, Zi-An Chen, Kun-Ju Lin, Ing-Tsung Hsiao, Tzu-Chen Yen, Mei-Ping Kung, Shiaw-Pyng Wey, Ching-Han Hsu
OBJECTIVE: Lactacystin has been used to establish rodent models of Parkinson disease (PD), with cerebral α-synuclein inclusions. This study evaluated the uptake of [(18)F]9-fluoropropyl-(+)-dihydrotetrabenazine ([(18)F]FP-(+)-DTBZ), a vesicular monoamine transporter type 2 (VMAT2)-targeting radiotracer, through positron emission tomography (PET) in lactacystin-treated rat brains. METHODS: Adult male Sprague-Dawley rats were randomly treated with a single intracranial dose of lactacystin (2 or 5 μg) or saline (served as the sham control) into the left medial forebrain bundle...
April 27, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28444503/comparative-evaluation-of-the-algorithms-for-parametric-mapping-of-the-novel-myocardial-pet-imaging-agent-18-f-fptp
#10
Ji Who Kim, Seongho Seo, Hyeon Sik Kim, Dong-Yeon Kim, Ho-Young Lee, Keon Wook Kang, Dong Soo Lee, Hee-Seung Bom, Jung-Joon Min, Jae Sung Lee
OBJECTIVE: ((18)F-fluoropentyl)triphenylphosphonium salt ((18)F-FPTP) is a new promising myocardial PET imaging tracer. It shows high accumulation in cardiomyocytes and rapid clearance from liver. We performed compartmental analysis of (18)F-FPTP PET images in rat and evaluated two linear analyses: linear least-squares (LLS) and a basis function method (BFM) for generating parametric images. The minimum dynamic scan duration for kinetic analysis was also investigated and computer simulation undertaken...
April 25, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28439784/practical-calculation-method-to-estimate-the-absolute-boron-concentration-in-tissues-using-18-f-fbpa-pet
#11
Tadashi Watabe, Kohei Hanaoka, Sadahiro Naka, Yasukazu Kanai, Hayato Ikeda, Masanao Aoki, Eku Shimosegawa, Mitsunori Kirihata, Jun Hatazawa
PURPOSE: The purpose of this study was to establish a practical method to estimate the absolute boron concentrations in the tissues based on the standardized uptake values (SUVs) after administration of 4-borono-phenylalanine (BPA) using 4-borono-2-(18)F-fluoro-phenylalanine ((18)F-FBPA) PET. METHODS: Rat xenograft models of C6 glioma (n = 7, body weight 241 ± 28.0 g) were used for the study. PET was performed 60 min after intravenous injection of (18)F-FBPA (30...
April 24, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28405882/iq-spect-for-thallium-201-myocardial-perfusion-imaging-effect-of-normal-databases-on-quantification
#12
Takahiro Konishi, Kenichi Nakajima, Koichi Okuda, Hiroto Yoneyama, Shinro Matsuo, Takayuki Shibutani, Masahisa Onoguchi, Seigo Kinuya
OBJECTIVE: Although IQ-single-photon emission computed tomography (SPECT) provides rapid acquisition and attenuation-corrected images, the unique technology may create characteristic distribution different from the conventional imaging. This study aimed to compare the diagnostic performance of IQ-SPECT using Japanese normal databases (NDBs) with that of the conventional SPECT for thallium-201 ((201)Tl) myocardial perfusion imaging (MPI). METHODS: A total of 36 patients underwent 1-day (201)Tl adenosine stress-rest MPI...
April 12, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28401400/glucose-uptake-of-the-muscle-and-adipose-tissues-in-diabetes-and-obesity-disease-models-evaluation-of-insulin-and-%C3%AE-3-adrenergic-receptor-agonist-effects-by-18-f-fdg
#13
Seigo Ishino, Taku Sugita, Yusuke Kondo, Mika Okai, Kazue Tsuchimori, Masanori Watanabe, Ikuo Mori, Masaki Hosoya, Takashi Horiguchi, Hidenori Kamiguchi
OBJECTIVE: One of the major causes of diabetes and obesity is abnormality in glucose metabolism and glucose uptake in the muscle and adipose tissue based on an insufficient action of insulin. Therefore, many of the drug discovery programs are based on the concept of stimulating glucose uptake in these tissues. Improvement of glucose metabolism has been assessed based on blood parameters, but these merely reflect the systemic reaction to the drug administered. We have conducted basic studies to investigate the usefulness of glucose uptake measurement in various muscle and adipose tissues in pharmacological tests using disease-model animals...
April 11, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28382589/age-related-effects-and-gender-differences-in-japanese-healthy-controls-for-123-i-fp-cit-spect
#14
Hideo Yamamoto, Shinichi Arimura, Atsushi Nakanishi, Yasushi Shimo, Yumiko Motoi, Koichi Ishiguro, Koji Murakami, Nobutaka Hattori, Shigeki Aoki
OBJECTIVE: Dopamine transporter (DAT) imaging with [(123)I]FP-CIT (DaTSCAN) is a widely used diagnostic tool for Parkinsonism and dementia. Since it was approved by the Japanese Ministry of Health, Labor, and Welfare in 2013, there have been no articles focusing on a Japanese normal population. The aim of this study was to examine the effect of aging and gender on DAT availability in Japanese people. METHODS: SPECT imaging of 30 healthy Japanese controls (17 males, 13 females; range 50-86 years, mean 70 years) was performed...
April 5, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28364376/incidental-spade-shaped-fdg-uptake-in-the-left-ventricular-apex-suggests-apical-hypertrophic-cardiomyopathy
#15
Mari Katagiri, Tadaki Nakahara, Mitsushige Murata, Yuji Ogata, Yohji Matsusaka, Yu Iwabuchi, Yoshitake Yamada, Keiichi Fukuda, Masahiro Jinzaki
PURPOSE: Apical wall thickening with an "ace-of-spades" configuration is a unique sign of apical hypertrophic cardiomyopathy (AHCM). We investigated spade-shaped FDG uptake around the left ventricular apex (SSUA) incidentally found in routine oncological FDG PET. METHODS: Cases showing SSUA were selected based on retrospective review. The pattern or intensity of SSUA was compared with the results of electrocardiogram (ECG), echocardiography, and stress myocardial perfusion SPECT...
March 31, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28353197/comparison-of-18f-fdg-pet-ct-and-18f-fdg-pet-mr-imaging-in-oncology-a-systematic-review
#16
Amit Singnurkar, Raymond Poon, Ur Metser
OBJECTIVE: The aim of this study was to systematically review the literature to evaluate the clinical performance of integrated (18)F-FDG PET/MR as compared with (18)F-FDG PET/CT in oncologic imaging. METHODS: The literature was searched using MEDLINE and EMBASE via OVID. Studies comparing the diagnostic accuracy of integrated (18)F-FDG PET/MR and (18)F-FDG PET/CT in the diagnosis, staging/restaging, assessment of treatment response, or evaluation of metastasis in patients with suspected or diagnosed cancers were deemed eligible for inclusion...
March 28, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28349331/compared-to-123-i-mibg-spect-ct-18-f-dopa-pet-ct-provides-accurate-tumor-extent-in-patients-with-extra-adrenal-paraganglioma
#17
Alexander Stephan Kroiss, Christian Uprimny, Barry Lynn Shulkin, Andreas Frech, Herbert Tilg, Rudolf Wolfgang Gasser, Georg Mathias Sprinzl, Leonhard Gruber, Claudius Thomé, Clemens Plangger, Christoph Url, Gustav Fraedrich, Irene Johanna Virgolini
AIM: The aim of this study was to compare the accuracy of (123)I-MIBG SPECT/CT with that of (18)F-DOPA PET/CT for staging extra-adrenal paragangliomas (PGLs) using both functional and anatomical images (i.e., combined cross-sectional imaging) as the reference standards. METHODS: Three men and seven women (age range 26-73 years) with anatomical and/or histologically proven disease were included in this study. Three patients had either metastatic head-and-neck paragangliomas (HNPGLs) or multifocal PGL, and seven patients had nonmetastatic disease...
March 27, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28342103/survival-and-prognostic-factors-after-adjuvant-131-iodine-labeled-lipiodol-for-hepatocellular-carcinoma-a-retrospective-analysis-of-106-patients-over-20-years
#18
Jonathan Olesinski, François Mithieux, Olivier Guillaud, Marie-Noëlle Hilleret, Catherine Lombard-Bohas, Luc Henry, Olivier Boillot, Thomas Walter, Christian Partensky, Pierre Paliard, Pierre-Jean Valette, Jean-Philippe Vuillez, Françoise Borson-Chazot, Jean-Yves Scoazec, Jérôme Dumortier
OBJECTIVE: Hepatocellular carcinoma (HCC) has high recurrence rate after curative treatment. The aim of the present study was to report our experience with adjuvant use of (131)I-lipiodol after curative treatment of HCC in terms of recurrence and survival in a large cohort of patients with a long follow-up. METHODS: All patients treated with (131)I-lipiodol after curative treatment of HCC in two French centers from 1991 to 2009 were included in a retrospective cohort study...
March 24, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28316066/long-term-results-and-tolerability-of-tandem-peptide-receptor-radionuclide-therapy-with-90-y-177-lu-dotatate-in-neuroendocrine-tumors-with-respect-to-the-primary-location-a-10-year-study
#19
Jolanta Kunikowska, Dariusz Pawlak, Marianna I Bąk, Beata Kos-Kudła, Renata Mikołajczak, Leszek Królicki
INTRODUCTION: The peptide receptor radionuclide therapy (PRRT) with (90)Y and (177)Lu is a form of molecular targeted therapy for inoperable or disseminated neuroendocrine tumors (NET). AIM: The aim of the study was to evaluate clinical results and long-term side effects of tandem (90)Y /(177)Lu-DOTATATE therapy in patients with NET. Additionally, we evaluated clinical results with reference to the primary site. MATERIALS AND METHODS: 59 patients with disseminated NET were included in the study prospectively...
March 18, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28361209/correlation-between-clinical-symptoms-and-striatal-dat-uptake-in-patients-with-dlb
#20
Soichiro Shimizu, Disuke Hirose, Nayuta Namioka, Hidekazu Kanetaka, Kentaro Hirao, Hirokuni Hatanaka, Naoto Takenoshita, Yoshitsugu Kaneko, Yusuke Ogawa, Takahiko Umahara, Hirofumi Sakurai, Haruo Hanyu
OBJECTIVE: It is widely known that there is low striatal (123)I-FP-CIT dopamine transporter-single photon emission tomography (DAT-SPECT) uptake in patients with dementia with Lewy bodies (DLB). We assessed the correlation between symptom and regional low DAT uptake in the striatum. METHODS: Patients with Alzheimer's disease (AD) (n = 95) and patients with DLB (n = 133) who underwent DAT-SPECT were enrolled. We examined the correlation between symptoms [cognitive function decline, fluctuations, visual hallucinations, parkinsonism, and REM sleep behavior disorder (RBD)] and regional striatal DAT uptake in the patients with DLB...
June 2017: Annals of Nuclear Medicine
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