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Annals of Nuclear Medicine

Yusuke Inoue, Kazunori Nagahara, Yuri Inoki, Toshimasa Hara, Hiroki Miyatake
OBJECTIVE: Radiation exposure in CT is modulated by automatic exposure control (AEC) mainly based on scout images. We evaluated CT radiation dose in whole-body PET/CT in relation to scout imaging direction and arm position, and investigated the behavior of AEC. METHODS: Eighty adult patients who underwent whole-body 18 F-FDG PET/CT were divided into groups A, B, C, and D. The posteroanterior scout image alone (PA scout) was used for AEC-based dose modulation in groups A and B, while the posteroanterior and lateral scout images (PA + Lat scout) were used in groups C and D...
November 10, 2018: Annals of Nuclear Medicine
Akira Joraku, Kentaro Hatano, Koji Kawai, Shuya Kandori, Takahiro Kojima, Nobuyoshi Fukumitsu, Tomonori Isobe, Yutaro Mori, Muneyuki Sakata, Tadashi Hara, Katsuhiro Nasu, Manabu Minami, Yuichi Iizumi, Hiroyuki Nishiyama
OBJECTIVE: We conducted the present phase I/IIa positron emission tomography (PET) imaging study with 89 Zr conjugated with desferroxamine-IAB2M (89 Zr-Df-IAB2M), an anti-prostate-specific membrane-antigen minibody, to assess its safety and feasibility in patients with urological cancer. METHODS: 89 Zr-Df-IAB2M was synthetized by IBA Molecular (Somerset, NJ, USA) and transported by air to Tsukuba Molecular Imaging Center (Tsukuba, Ibaraki, Japan).17 patients received 74 MBq (2 mCi) of 89 Zr-Df-IAB2M at total mass doses of 10 mg...
November 7, 2018: Annals of Nuclear Medicine
Terje Løitegård, Dag T Berntzen, Espen Thiis-Evensen
OBJECTIVE: The Response Evaluation Criteria In Solid Tumors (RECIST) is the most used radiological method for evaluating response after peptide receptor radionuclide therapy (PRRT) in patients with neuroendocrine tumors. This method may give too positive estimates of response in slow growing tumors as it allows a substantial increase in tumor size before patients are classified as having progressive disease. We wanted to compare RECIST with a conventional method in routine use for estimating treatment effect based on defining any unequivocal increase in size of tumor load as progressive disease...
November 7, 2018: Annals of Nuclear Medicine
Shan Zheng, Zhenying Chen, Chao Huang, Yun Chen, Weibing Miao
OBJECTIVES: This study was designed to investigate the efficacy of 99m technetium-three polyethylene glycol spacers-arginine-glycine-aspartic acid ([99m Tc]3PRGD2 ) in the evaluation of patients with esophageal cancer. METHODS: Twenty-nine patients with a suspected esophageal lesion and for whom definite pathological diagnosis was finally obtained were recruited. Whole-body planar scanning and chest single-photon-emission computed tomography/computed tomography (SPECT/CT) were performed at 30 and 40 min, respectively, after intravenous injection of 11...
November 3, 2018: Annals of Nuclear Medicine
Joon Ho Choi, Ilhan Lim, Inki Lee, Byung Hyun Byun, Byung Il Kim, Chang Woon Choi, Sang Moo Lim
OBJECTIVE: The aim of this study was to investigate if increased serum thyroglobulin (Tg) levels after radioactive iodine (RAI) showed more therapeutic effects in patients with differentiated thyroid cancer (DTC). METHODS: Data of 65 patients with DTC who underwent RAI from June 2014 to September 2016 were reviewed. Serum thyroglobulin was measured immediately before (Tg1) and 48 h (Tg2) after RAI under TSH stimulation. Differences and ratios between serum Tg measurements (DeltaTg = Tg2 - Tg1 and RatioTg = Tg2/Tg1) were calculated...
October 31, 2018: Annals of Nuclear Medicine
Wei Lan, Zhao Gege, Lv Ningning, Wen Qiang, Bai Lin, Ma Qingjie, Ji Bin
OBJECTIVE: Negative 99m Tc-pertechnetate uptake of the thyroid bed indicates the absence or a small volume of remnant thyroid tissue (RTT) after total thyroidectomy (TT). The aim of this study is to evaluate the predictive value of negative 99m Tc-pertechnetate scintigraphy for excellent response (ER) to radioactive iodine therapy (RIT) in low- to intermediate-risk differentiated thyroid cancer (DTC) patients. PATIENTS: One-hundred and eighty-nine low- to intermediate-risk DTC patients who underwent TT, RIT with a single dose of 30 mCi and suppressive therapy with thyroid-stimulating hormone (TSH) from July 2015 to February 2016 in our hospital were retrospectively evaluated...
October 29, 2018: Annals of Nuclear Medicine
Getu Ferenji Tadesse, Parham Geramifar, Eyachew Misganew Tegaw, Mohammad Reza Ay
To reliably interpret and perform quantitative analysis, attenuation correction for cardiac single-photon emission computed tomography (SPECT) is fundamental. Thus, knowledge of the patient-specific attenuation map for accurate correction is required in SPECT quantitative imaging. The aim of this systematic review is to present general principles of attenuation correction and provide a structured summary of the approaches that have been proposed for generating the attenuation map for cardiac SPECT. We identified relevant articles published in English pertaining to the attenuation map (AM) determination using SPECT emission data only by searching PubMed, EMBASE, Scopus, and Web of Science databases...
October 22, 2018: Annals of Nuclear Medicine
Chang Yi, Xinchong Shi, Xuezhen Zhang, Ganhua Luo, Bing Zhang, Xiangsong Zhang
OBJECTIVE: To investigate the utility of 13 N-ammonia PET/CT imaging in the differential diagnosis of gliomas and brain inflammations. METHODS: 13 N-ammonia PET/CT imaging data of 77 patients with gliomas and 34 patients with brain inflammations were retrospectively analyzed. No patients received any treatment before 13 N-ammonia imaging. All the patients were diagnosed by stereotactic biopsy or clinical follow-up. Visual and semi-quantitative analysis was performed to analyze the results of 13 N-ammonia imaging...
October 22, 2018: Annals of Nuclear Medicine
Takayuki Shibutani, Masahisa Onoguchi, Hiroto Yoneyama, Takahiro Konishi, Shinro Matsuo, Kenichi Nakajima
OBJECTIVES: Although the utility of IQ-SPECT imaging using 99m Tc and 201 Tl myocardial perfusion SPECT has been reported, 123 I-labeled myocardial SPECT has not been fully evaluated. We determined the characteristics and utility of 123 I IQ-SPECT imaging compared with conventional SPECT (C-SPECT). METHODS: Two myocardial phantom patterns were used to simulate normal myocardium and myocardial infarction. SPECT acquisition was performed using a hybrid dual-head SPECT/CT system equipped with a SMARTZOOM collimator for IQ-SPECT or a low-medium energy general purpose collimator for C-SPECT...
October 15, 2018: Annals of Nuclear Medicine
Young Wha Koh, Su Jin Lee, Seong Yong Park
OBJECTIVE: We explored the relationship between preoperative 18 F-FDG-PET parameters, tumor necrosis, and microvessel density (MVD) in patients with pulmonary adenocarcinomas. METHODS: A total of 164 patients, who underwent surgical resection for lung adenocarcinoma, were reviewed retrospectively. The maximum standardized uptake value (SUVmax ), peak SUV corrected for lean body mass (SULpeak ), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) values were measured by preoperative 18 F-FDG-PET...
October 15, 2018: Annals of Nuclear Medicine
Takayuki Shibutani, Kenichi Nakajima, Hiroshi Wakabayashi, Hiroshi Mori, Shinro Matsuo, Hiroto Yoneyama, Takahiro Konishi, Koichi Okuda, Masahisa Onoguchi, Seigo Kinuya
OBJECTIVES: The patient-based diagnosis with an artificial neural network (ANN) has shown potential utility for the detection of coronary artery disease; however, the region-based accuracy of the detected regions has not been fully evaluated. The aim of this study was to demonstrate the accuracy of all detected regions compared with expert interpretation. METHODS: A total of 109 abnormal regions including 33 regions with stress defects and 76 regions with ischemia were examined, which were derived from 21 patients who underwent myocardial perfusion SPECT within 45 days of coronary angiography...
October 9, 2018: Annals of Nuclear Medicine
Hiroto Sasamori, Kimiichi Uno, Jin Wu
OBJECTIVE: Positron emission tomography/computed tomography (PET/CT) with fluorodeoxyglucose (F18-FDG) is useful for the detection of malignant lesions, including metastatic lesions, and this technique is widely used in cancer screening. However, this approach may occasionally yield false-positive and false-negative findings. At our PET center, to increase the accuracy of PET/CT, we use PET/CT and whole-body diffusion-weighted imaging (WB-DWI) together. This study aimed to assess the usefulness of this combination...
October 8, 2018: Annals of Nuclear Medicine
Joachim Brumberg, Johannes Tran-Gia, Constantin Lapa, Ioannis U Isaias, Samuel Samnick
OBJECTIVE: In subjects with idiopathic Parkinson's disease (PD) the functional state of the locus coeruleus and the subtle derangements in the finely tuned dopamine-noradrenaline interplay are largely unknown. The PET ligand (S,S)-[11 C]-O-methylreboxetine (C-11 MRB) has been described to reliably bind noradrenaline transporters but long scanning protocols might hamper its use, especially in patients with PD. We aimed to assess the feasibility of reducing C-11 MRB scans to 30 min. METHODS: Ten patients with idiopathic PD underwent dynamic C-11 MRB PET (120 min duration) and brain magnetic resonance imaging...
October 6, 2018: Annals of Nuclear Medicine
Mahmudur G M Rahman, Muhammad M Islam, Tetsuya Tsujikawa, Yasushi Kiyono, Hidehiko Okazawa
OBJECTIVE: To calculate the specific binding ratio (SBR) appropriately in dopamine transporter (DAT) imaging, a method for extracting the striatal volume of interest (VOI) was developed. METHODS: This study included 200 patients (72 ± 10 years) who were suspected of parkinsonian syndromes (PS) or dementia with Lewy body (DLB). The patients were divided into three groups of PS with dopaminergic degeneration, DLB and non-PS after [123 I]ioflupane (FP-CIT) SPECT and clinical follow-up...
October 1, 2018: Annals of Nuclear Medicine
Yuji Nakamoto, Takayoshi Ishimori, Kohei Sano, Yoichi Shimizu, Kaori Togashi
OBJECTIVE: Positron emission tomography (PET)/computed tomography (CT) using 68 Ga-labeled 1,4,7,10-tetraazacyclododecane-N,N',N″,N‴-tetraacetic acid-D-Phe1 -Tyr3 -octreotide (DOTATOC) is usually performed about 1-h post-injection; however, because of rapid blood clearance, the waiting time for scanning could possibly be shortened without affecting diagnostic performance. The purpose of this study was to investigate the feasibility of early scanning at 30 min post-injection. METHODS: Thirty-eight patients who underwent DOTATOC-PET/CT were analyzed...
September 20, 2018: Annals of Nuclear Medicine
Xavier Palard-Novello, Luc Beuzit, Giulio Gambarota, Florence Le Jeune, Etienne Garin, Pierre-Yves Salaün, Anne Devillers, Solène Querellou, Patrick Bourguet, Hervé Saint-Jalmes
AIM: 18 F-Choline (FCH) uptake parameters are strong indicators of aggressive disease in prostate cancer. Functional parameters derived by magnetic resonance imaging (MRI) are also correlated to aggressive disease. The aim of this work was to evaluate the relationship between metabolic parameters derived by FCH PET/CT and functional parameters derived by MRI. MATERIALS AND METHODS: Fourteen patients with proven prostate cancer who underwent FCH PET/CT and multiparametric MRI were enrolled...
September 15, 2018: Annals of Nuclear Medicine
Ningning Lv, Shi Gao, Lin Bai, Bin Ji, Jinru Xue, Xiaoguang Ge, Bin Chen
BACKGROUND: Our study was designed to compare the diagnostic efficacies of integrated 99m Tc-HYNIC-PEG4-E[PEG4-c(RGDfK)]2 (99m Tc-3PRGD2 ) single-photon emission computed tomography (SPECT) images and computed tomography (CT) images in lymph node metastasis in the patients with esophageal cancer. METHODS: From September 2015 and May 2018, 32 patients with histologically proven primary esophageal carcinoma underwent both 99m Tc-3PRGD2 SPECT and CT scans followed by esophagectomy with lymph node dissection...
September 14, 2018: Annals of Nuclear Medicine
Junyan Xu, Yi Li, Silong Hu, Linjun Lu, Zhiqi Gao, Huiyu Yuan
OBJECTS: The purpose was to evaluate the correlation of the pre-treatment hematological parameters with metabolic parameters of primary tumor in baseline 18 F-FDG PET/CT in patients with colorectal cancer (CRC) and estimate the prognostic value of both. METHODS: We retrospectively investigated 231 patients with CRC who underwent baseline 18 F-FDG PET/CT. Routine blood sampling was tested in the same term. PET parameters in term of hematological parameters and pathological characteristics of primary tumor were compared...
September 14, 2018: Annals of Nuclear Medicine
Tomoka Kitao, Tohru Shiga, Kenji Hirata, Mitsunori Sekizawa, Toshiki Takei, Katsushige Yamashiro, Nagara Tamaki
INTRODUCTION: Soft-tissue sarcomas (STS) are rare types of tumors that have variable levels of tumor differentiation. F-18 fluorodeoxyglucose positron emission tomography (FDG PET) has been established as an useful tool for STS patients, and the metabolic tumor volume (MTV) and total lesion glycolysis (TLG) are reported to be useful in various cancers. We compared the diagnostic value of four PET parameters (maximum standardized uptake value [SUVmax], SUVmean, MTV, and TLG) from two acquisition timings for predicting the expression of the pathological marker of cell proliferation Ki-67, based on pathological investigation...
September 8, 2018: Annals of Nuclear Medicine
Hoda Anwar, Thomas J Vogl, Mahasen A Abougabal, Frank Grünwald, Peter Kleine, Sherif Elrefaie, Nour-Eldin A Nour-Eldin
OBJECTIVE: Administration of postoperative chemotherapy to patients with completely resected stage I NSCLC is still a matter of debate. The aim of the present study was to evaluate the value of different baseline 18 F-FDG PET parameters in identifying surgical stage I NSCLC patients who are at high risk of recurrence, and thus are indicated for further postoperative treatment. METHODS: This is a retrospective study, which included 49 patients (28 males, 21 females) with the median age of 69 years (range 28-84), who had pathologically proven stage I NSCLC...
December 2018: Annals of Nuclear Medicine
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