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Annals of Nuclear Medicine

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https://www.readbyqxmd.com/read/28316066/long-term-results-and-tolerability-of-tandem-peptide-receptor-radionuclide-therapy-with-90-y-177-lu-dotatate-in-neuroendocrine-tumors-with-respect-to-the-primary-location-a-10-year-study
#1
Jolanta Kunikowska, Dariusz Pawlak, Marianna I Bąk, Beata Kos-Kudła, Renata Mikołajczak, Leszek Królicki
INTRODUCTION: The peptide receptor radionuclide therapy (PRRT) with (90)Y and (177)Lu is a form of molecular targeted therapy for inoperable or disseminated neuroendocrine tumors (NET). AIM: The aim of the study was to evaluate clinical results and long-term side effects of tandem (90)Y /(177)Lu-DOTATATE therapy in patients with NET. Additionally, we evaluated clinical results with reference to the primary site. MATERIALS AND METHODS: 59 patients with disseminated NET were included in the study prospectively...
March 18, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28315150/radioiodination-and-preclinical-evaluation-of-4-benzyl-1-3-125-i-iodobenzylsulfonyl-piperidine-as-a-breast-tumor-imaging-tracer-in-mouse
#2
Masoud Sadeghzadeh, Behrouz Alirezapour, Ghorban Ali Charkhlooie, Maryam Keshavarz Baghery, Amir Khorouti
OBJECTIVE: 4-Benzyl-1-(3-iodobenzylsulfonyl)piperidine, 4-B-IBSP, has shown high-binding affinity to both sigma (σ) receptors in our previous work. In current study, radiolabeling and preclinical evaluation of 4-benzyl-1-(3-[(125)I]-iodobenzylsulfonyl)piperidine, 4-B-[(125)I]IBSP, in human ductal breast carcinoma (T47D) cells and in breast adenocarcinoma-bearing BALB/c mice are described. METHODS: Radioiodination of this new σ ligand was performed by a palladium-catalyzed stannylation approach followed by oxidative iododestannylation reaction using Iodo-Gen...
March 17, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28299585/serial-imaging-using-18f-fluorodeoxyglucose-positron-emission-tomography-and-histopathologic-assessment-in-predicting-survival-in-a-population-of-surgically-resectable-distal-oesophageal-and-gastric-adenocarcinoma-following-neoadjuvant-therapy
#3
Varun Manoharan, Soon Lee, Shanley Chong, June Yap, Nick Coupe, Robert Wilson, Neil Merrett, Weng Ng, Michael Lin
BACKGROUND AND OBJECTIVES: We retrospectively evaluated the value of PET/CT in predicting survival and histopathological tumour-response in patients with distal oesophageal and gastric adenocarcinoma following neoadjuvant treatment. METHODS: Twenty-one patients with resectable distal oesophageal adenocarcinoma and 14 with gastric adenocarcinoma between January 2002 and December 2011, who had undergone serial PET before and after neoadjuvant therapy followed by surgery, were enrolled...
March 15, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28275975/design-and-performance-evaluation-of-a-new-high-energy-parallel-hole-collimator-for-radioiodine-planar-imaging-by-gamma-cameras-monte-carlo-simulation-study
#4
Vahid Moslemi, Mansour Ashoor
OBJECTIVE: In addition to the trade-off between resolution and sensitivity which is a common problem among all types of parallel hole collimators (PCs), obtained images by high energy PCs (HEPCs) suffer from hole-pattern artifact (HPA) due to further septa thickness. In this study, a new design on the collimator has been proposed to improve the trade-off between resolution and sensitivity and to eliminate the HPA. METHODS: A novel PC, namely high energy extended PC (HEEPC), is proposed and is compared to HEPCs...
March 8, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28260185/-11-c-l-methyl-methionine-dynamic-pet-ct-of-skeletal-muscle-response-to-protein-supplementation-compared-to-l-ring-13-c6-phenylalanine-infusion-with-serial-muscle-biopsy
#5
Emily J Arentson-Lantz, Isra H Saeed, Lynda A Frassetto, Umesh Masharani, Roy J Harnish, Youngho Seo, Henry F VanBrocklin, Randall A Hawkins, Carina Mari-Aparici, Miguel H Pampaloni, James Slater, Douglas Paddon-Jones, Thomas F Lang
OBJECTIVE: The objective of this study was to determine if clinical dynamic PET/CT imaging with (11)C-L-methyl-methionine ((11)C-MET) in healthy older women can provide an estimate of tissue-level post-absorptive and post-prandial skeletal muscle protein synthesis that is consistent with the more traditional method of calculating fractional synthesis rate (FSR) of muscle protein synthesis from skeletal muscle biopsies obtained during an infusion of L-[ring (13)C6] phenylalanine ((13)C6-Phe)...
March 4, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28243845/pixel-by-pixel-precise-delay-correction-for-measurement-of-cerebral-hemodynamic-parameters-in-h2-15-o-pet-study
#6
Muhammad M Islam, Tetsuya Tsujikawa, Tetsuya Mori, Yasushi Kiyono, Hidehiko Okazawa
OBJECTIVE: A new method of delay time estimation was proposed to measure precise cerebral blood flow (CBF) and arterial-to-capillary blood volume (V 0) using (15)O-water PET. METHODS: Nineteen patients with unilateral arterial stenoocclusive lesions were studied to evaluate hemodynamic status before treatment. The delay time of each pixel was calculated using least squares fitting with an arterial blood input curve adjusted to the internal carotid artery counts at the skull base...
February 27, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28243844/3d-spect-ct-fusion-using-image-data-projection-of-bone-spect-onto-3d-volume-rendered-ct-images-feasibility-and-clinical-impact-in-the-diagnosis-of-bone-metastasis
#7
Yuji Ogata, Tadaki Nakahara, Kenichi Ode, Yohji Matsusaka, Mari Katagiri, Yu Iwabuchi, Kazunari Itoh, Akira Ichimura, Masahiro Jinzaki
PURPOSE: We developed a method of image data projection of bone SPECT into 3D volume-rendered CT images for 3D SPECT/CT fusion. The aims of our study were to evaluate its feasibility and clinical usefulness. METHODS: Whole-body bone scintigraphy (WB) and SPECT/CT scans were performed in 318 cancer patients using a dedicated SPECT/CT systems. Volume data of bone SPECT and CT were fused to obtain 2D SPECT/CT images. To generate our 3D SPECT/CT images, colored voxel data of bone SPECT were projected onto the corresponding location of the volume-rendered CT data after a semi-automatic bone extraction...
February 27, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28205000/aortic-knob-width-reflects-left-ventricular-diastolic-function-assessed-by-gated-myocardial-perfusion-single-photon-emission-computed-tomography-in-patients-with-normal-myocardial-perfusion
#8
Satoshi Kurisu, Tadanao Higaki, Yoji Sumimoto, Hiroki Ikenaga, Noriaki Watanabe, Ken Ishibashi, Yoshihiro Dohi, Yukihiro Fukuda, Yasuki Kihara
BACKGROUND: Aortic knob width on chest radiography represents the extent of aortic dialation and tortuosity of the aortic arch. We tested the hypothesis that aortic knob width reflected left ventricular (LV) diastolic function assessed by gated myocardial perfusion single photon emission computed tomography (SPECT) in patients with normal myocardial perfusion. METHODS: One hundred and thirty patients with preserved LV ejection fraction and normal myocardial perfusion were enrolled in this study...
February 15, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28197975/research-of-predictive-factors-for-cardiac-resynchronization-therapy-a-prospective-study-comparing-data-from-phase-analysis-of-gated-myocardial-perfusion-single-photon-computed-tomography-and-echocardiography-trying-to-anticipate-response-to-crt
#9
Rémy Gendre, O Lairez, P Mondoly, A Duparc, D Carrié, M Galinier, I Berry, T Cognet
BACKGROUND: Cardiac resynchronization therapy (CRT) reduces morbidity and mortality in chronic systolic heart failure. About 20% of implanted patients are considered as "non-responders". This study aimed to evaluate gated myocardial perfusion single-photon emission computed tomography (GMPS) phase parameters as compared to echocardiography in the assessment of predictors for response to CRT before and after CRT activation. METHODS: Forty-two patients were prospectively included during 15 months...
February 14, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28194701/an-automated-voxel-based-method-for-calculating-the-reference-value-for-a-brain-tumour-metabolic-index-using-18-f-fdg-pet-and-11-c-methionine-pet
#10
Miwako Takahashi, Tsutomu Soma, Akitake Mukasa, Keitaro Koyama, Takuya Arai, Toshimitsu Momose
OBJECTIVE: The tumour-to-normal ratio (T/N) is a representative index reflecting brain tumour activity by (18)F-fluorodeoxyglucose (FDG) and (11)C-methionine (MET) PET. We proposed a new automated method of calculating the normal reference value (N-value) for use as the denomination of T/N. This method uses voxel-based analysis of FDG- and MET-PET images. We compared the results of this method with those of the standard region-of-interest (ROI) method. METHODS: Data sets were obtained from 32 patients with newly diagnosed glioma and 13 patients with recurrent brain tumour...
February 13, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28181119/visual-evaluation-of-kinetic-characteristics-of-pet-probe-for-neuroreceptors-using-a-two-phase-graphic-plot-analysis
#11
Hiroshi Ito, Yoko Ikoma, Chie Seki, Yasuyuki Kimura, Hiroshi Kawaguchi, Hiroyuki Takuwa, Masanori Ichise, Tetsuya Suhara, Iwao Kanno
Objectives In PET studies for neuroreceptors, tracer kinetics are described by the two-tissue compartment model (2-TCM), and binding parameters, including the total distribution volume (V T), non-displaceable distribution volume (V ND), and binding potential (BPND), can be determined from model parameters estimated by kinetic analysis. The stability of binding parameter estimates depends on the kinetic characteristics of radioligands. To describe these kinetic characteristics, we previously developed a two-phase graphic plot analysis in which V ND and V T can be estimated from the x-intercept of regression lines for early and delayed phases, respectively...
February 8, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28181118/brain-uptake-and-safety-of-flutemetamol-f-18-injection-in-japanese-subjects-with-probable-alzheimer-s-disease-subjects-with-amnestic-mild-cognitive-impairment-and-healthy-volunteers
#12
Takami Miki, Hiroyuki Shimada, Jae-Seung Kim, Yasuji Yamamoto, Masakazu Sugino, Hisatomo Kowa, Kerstin Heurling, Michelle Zanette, Paul F Sherwin, Michio Senda
OBJECTIVE: This Phase 2 study assessed the performance of positron emission tomography (PET) brain images made with Flutemetamol F 18 Injection in detecting β-amyloid neuritic plaques in Japanese subjects. METHODS: Seventy subjects (25 with probable Alzheimer's disease (pAD), 20 with amnestic mild cognitive impairment (aMCI), and 25 cognitively normal healthy volunteers[HVs]) underwent PET brain imaging after intravenous Flutemetamol F 18 Injection (185 MBq). Images were interpreted as normal or abnormal for neuritic plaque density by each of five non-Japanese and five Japanese readers who were blinded to clinical data...
February 8, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28168397/clinical-correlation-of-metabolic-parameters-on-18-f-fdg-pet-ct-in-idiopathic-frozen-shoulder
#13
Kyoung Sook Won, Du Hwan Kim, Duk Hyun Sung, Bong-Il Song, Hae Won Kim, Kwang-Soon Song, Si-Wook Lee, Chul-Hyun Cho
OBJECTIVE: Because positron emission tomography/computed tomography (PET/CT) using fluorine-18-fluorodeoxyglucose ((18)F-FDG) can be used to visualize inflammation of the musculoskeletal system, it may help elucidate the pathophysiology of frozen shoulder (FS). The purpose of this study was to characterize the uptake pattern on (18)F-FDG PET/CT in patients with idiopathic FS and to determine if there is a correlation between its metabolic parameters and clinical findings. METHODS: (18)F-FDG PET/CT was conducted to 35 patients with unilateral idiopathic FS...
February 6, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28144811/influence-of-acquisition-orbit-on-phase-analysis-of-gated-single-photon-emission-computed-tomography-myocardial-perfusion-imaging-for-assessment-of-left-ventricular-mechanical-dyssynchrony
#14
Tomofumi Misaka, Makoto Hosono, Takashi Kudo, Takamichi Ito, Tsutomu Syomura, Masanobu Uemura, Kaoru Okajima
OBJECTIVE: The association between left ventricular (LV) dyssynchrony parameters, given by phase analysis of gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI), and acquisition orbits is unclear. The aim of this study was to assess the dependence of LV dyssynchrony parameters on acquisition orbits. METHODS: Ninety-nine patients who underwent (201)Tl-gated SPECT MPI were categorized into minor hypoperfusion or major hypoperfusion groups...
January 31, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28220365/binding-of-11-c-pittsburgh-compound-b-correlated-with-white-matter-injury-in-hypertensive-small-vessel-disease
#15
Tetsuya Hashimoto, Chiaki Yokota, Kazuhiro Koshino, Takashi Temma, Makoto Yamazaki, Satoshi Iguchi, Ryo Shimomura, Toshiyuki Uehara, Naoko Funatsu, Tenyu Hino, Kazuo Minematsu, Hidehiro Iida, Kazunori Toyoda
OBJECTIVE: (11)C-Pittsburgh compound-B ((11)C-PIB) positron emission tomography (PET) is used to visualize and quantify amyloid deposition in the brain cortex in pathological conditions such as Alzheimer's disease (AD). Intense (11)C-PIB retention is also observed in the white matter (WM) of both healthy individuals and AD patients. However, the clinical implications of this retention in brain WM have not been clarified. We investigated the relationship between the extent of white matter lesions (WMLs) and the binding potential of (11)C-PIB (BPND) in the WM in patients with hypertensive small vessel disease...
April 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28012120/improvement-in-automated-quantitation-of-myocardial-perfusion-abnormality-by-using-iterative-reconstruction-image-in-combination-with-resolution-recovery-attenuation-and-scatter-corrections-for-the-detection-of-coronary-artery-disease
#16
Taiki Chono, Masahisa Onoguchi, Takayuki Shibutani, Akiyoshi Hashimoto, Tomoaki Nakata, Naoya Yama, Kazufumi Tsuchihashi, Masamitsu Hatakenaka
OBJECTIVE: An iterative reconstruction method in combination with resolution recovery, attenuation and scatter corrections (IR-RASC) can improve image quality. It, however, is undetermined whether this technique can improve the detection of coronary artery disease (CAD) when automated quantitative analysis is used. This study evaluated diagnostic values of IR-RASC in combination with automated quantitative analysis in stress myocardial perfusion imaging (MPI) in the CAD detection. METHODS: This study enrolled consecutive 64 patients (mean age 66...
February 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28000164/respiratory-average-ct-for-attenuation-correction-in-myocardial-perfusion-spect-ct
#17
Duo Zhang, Bang-Hung Yang, Nien Yun Wu, Greta Seng Peng Mok
OBJECTIVE: Cine average CT (CACT) and interpolated average CT (IACT) have been proposed to improve attenuation correction (AC) for PET/CT in oncologic and cardiac studies. This study aims to evaluate their effectiveness on myocardial perfusion SPECT/CT using computer simulation and physical phantom experiments. METHODS: We first simulated normal male with (99m)Tc-sestamibi distribution using digital XCAT phantom with respiratory motion amplitudes of 2, 3, and 4 cm...
February 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27921286/-18-f-fdg-pet-ct-to-differentiate-malignant-necrotic-lymph-node-from-benign-cystic-lesions-in-the-neck
#18
Peymaneh Abadi, Allan Johansen, Christian Godballe, Oke Gerke, Poul Flemming Høilund-Carlsen, Anders Thomassen
OBJECTIVE: Patients presenting with cystic lesions in the neck without obvious signs of malignancy constitute a diagnostic challenge since fine needle aspiration is often insufficient and a diagnosis may not be reached until surgical resection/biopsy is performed. The differential diagnosis of a cystic cervical mass comprises a variety of benign conditions, but malignancy must be ruled out. We examined the diagnostic performance of fluorine-18 fluorodeoxyglucose ((18)F-FDG) PET/CT to identify malignancy...
February 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27921285/spatiotemporal-distribution-modeling-of-pet-tracer-uptake-in-solid-tumors
#19
Madjid Soltani, Mostafa Sefidgar, Hossein Bazmara, Michael E Casey, Rathan M Subramaniam, Richard L Wahl, Arman Rahmim
OBJECTIVE: Distribution of PET tracer uptake is elaborately modeled via a general equation used for solute transport modeling. This model can be used to incorporate various transport parameters of a solid tumor such as hydraulic conductivity of the microvessel wall, transvascular permeability as well as interstitial space parameters. This is especially significant because tracer delivery and drug delivery to solid tumors are determined by similar underlying tumor transport phenomena, and quantifying the former can enable enhanced prediction of the latter...
February 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27914043/a-revisit-to-quantitative-pet-with-18-f-fdopa-of-high-specific-activity-using-a-high-resolution-condition-in-view-of-application-to-regenerative-therapy
#20
Go Akamatsu, Akihito Ohnishi, Kazuki Aita, Hiroyuki Nishida, Yasuhiko Ikari, Masahiro Sasaki, Nobuo Kohara, Michio Senda
OBJECTIVE: With the advent of regenerative/cell therapy for Parkinson's disease (PD), (18)F-FDOPA has drawn new attention as a biomarker of the therapeutic that cannot be evaluated with radiopharmaceuticals for dopamine transporter. Since most previous (18)F-FDOPA PET studies were carried out many years ago with a PET scanner of lower resolution and with (18)F-FDOPA of low specific activity synthesized from (18)F-F2, we used a newer PET/CT scanner with a high-resolution condition and (18)F-FDOPA synthesized from (18)F-F(-) to re-evaluate this technique on normal subjects and patients with PD, together with D2 receptor imaging with (11)C-raclopride (RAC)...
February 2017: Annals of Nuclear Medicine
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