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Annals of Nuclear Medicine

Yuan Qu, Rui Huang, Lin Li
OBJECTIVES: To compare the ablation results, therapeutic responses and adverse reactions between a low dose (1.1 GBq) or high dose (3.7 GBq) of (131)I in low-/intermediate-risk differentiated thyroid cancer (DTC) patients. The factors influencing the ablation result and therapeutic response were also analyzed. METHODS: The researchers used a random number table to randomly assign the enrolled patients to the low-dose group or high-dose group at a 1:1 ratio, and assessment of ablation result, therapeutic response, and adverse reactions evaluated 6 ± 3 months after therapy...
October 18, 2016: Annals of Nuclear Medicine
Kiichi Ishiwata, Kunpei Hayashi, Masanari Sakai, Sugio Kawauchi, Hideaki Hasegawa, Jun Toyohara
OBJECTIVE: To elucidate the radionuclides and radiochemical impurities included in radiosynthesis processes of positron emission tomography (PET) tracers. METHODS: Target materials and PET tracers were produced using a cyclotron/synthesis system from Sumitomo Heavy Industry. Positron and γ-ray emitting radionuclides were quantified by measuring radioactivity decay and using the high-purity Ge detector, respectively. Radiochemical species in gaseous and aqueous target materials were analyzed by gas and ion chromatography, respectively...
October 15, 2016: Annals of Nuclear Medicine
Katsuya Mitamura, Yuka Yamamoto, Nobuyuki Kudomi, Yukito Maeda, Takashi Norikane, Keisuke Miyake, Yoshihiro Nishiyama
BACKGROUND: The nucleoside analog 3'-deoxy-3'-(18)F-fluorothymidine (FLT) has been investigated for evaluating tumor proliferating activity in brain tumors. We evaluated FLT uptake heterogeneity using textural features from the histogram analysis in patients with newly diagnosed gliomas and examined correlation of the results with proliferative activity and patient prognosis, in comparison with the conventional PET parameters. METHODS: FLT PET was investigated in 37 patients with newly diagnosed gliomas...
September 29, 2016: Annals of Nuclear Medicine
Misugi Urano, Yumi Maki, Hiroko Nishikawa, Tatsuya Kawai, Norio Shiraki, Yuta Shibamoto
OBJECTIVE: To compare the diagnostic ability of planar images (PI) and images obtained by a computer-aided diagnosis (CAD) system (Viewer for Standardized Bone Scintigraphies; VSBONE) of whole-body bone scintigraphy for detecting bone metastases in breast cancer patients. METHODS: 81 women (median: 56 years; range: 32-79) with a history of breast cancer were included in this study. They underwent whole-body bone scintigraphy after intravenous injection of 740 MBq technetium-99m hydroxymethylene diphosphonate...
September 29, 2016: Annals of Nuclear Medicine
Mayumi Okamoto, Kyosuke Naka, Kiichi Ishiwata, Isao Shimizu, Jun Toyohara
OBJECTIVE: 7α-Substituted androgen derivatives may have the potential to visualize androgen receptors with positron emission tomography. In the present study, we synthesized fluoropropyl derivatives of 7α-(3-[(18)F]fluoropropyl)-testosterone ([(18)F]7) and 7α-(3-[(18)F]fluoropropyl)-dihydrotestosterone ([(18)F]15), and characterized their in vitro binding, in vivo biodistribution, and performed blocking studies in mature androgen deprived male rats. METHODS: We synthesized [(18)F]7 and [(18)F]15...
September 28, 2016: Annals of Nuclear Medicine
M Shirin Shandiz, H Saligheh Rad, P Ghafarian, M Bakhshayesh Karam, Afshin Akbarzadeh, Mohammad Reza Ay
PURPOSE: Prostate imaging is one of the major application of hybrid PET/MRI systems. Inaccurate attenuation maps (µ-maps) derived by direct segmentation (SEG) in which the cortical bone is ignored and the volume of the air in cavities is underestimated is the main challenge of commercial PET/MRI systems for the quantitative analysis of the pelvic region. The present study considered the cortical bone and air cavity along with soft tissue, fat, and background air in the µ-map of the pelvic region using a method based on SEG...
September 28, 2016: Annals of Nuclear Medicine
Hiroshi Hoshikawa, Terushige Mori, Yukito Maeda, Satoshi Takahashi, Yohei Ouchi, Yuka Yamamoto, Yoshihiro Nishiyama
OBJECTIVE: This prospective study compared the value of pretreatment 4'-[methyl-(11)C]-thiothymidine ((11)C-4DST) volumetric parameters and those of 2-deoxy-2-[18F] fluoro-D-glucose ((18)F-FDG) in predicting the clinical outcome in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: Fifty patients with HNSCC underwent (11)C-4DST PET/CT and (18)F-FDG PET/CT prior to anticancer therapy. (18)F-FDG metabolic tumor volume ((18)F-FDG MTV) and total lesion glycolysis (TLG) were calculated from (18)F-FDG PET, and (11)C-4DST MTV and total lesion proliferation (TLP) were calculated from (11)C-4DST PET...
September 27, 2016: Annals of Nuclear Medicine
Kotaro Higashi, Toshiaki Yamagishi, Yoshimichi Ueda, Yasuhito Ishigaki, Miyako Shimasaki, Yuka Nakamura, Manabu Oguchi, Tsutomu Takegami, Motoyasu Sagawa, Hisao Tonami
OBJECTIVES: Hypoxia is a key element involved in the development and progression of tumors. HIF-1α may transiently induce and mediate the response to acute and severe hypoxia, while HIF-2α may induce a longer response and may control the response to chronic and moderate hypoxia. Hypoxia increases the cellular uptake of FDG. Therefore, HIF may play an important role in the process of the cellular uptake of FDG. The aim of this study was to compare HIF-1α/HIF-2α expression with FDG uptake, Glut-1 expression, and prognosis in the patients with lung adenocarcinoma and to investigate the role of HIF-1α/HIF-2α in the uptake of FDG in lung adenocarcinoma...
September 23, 2016: Annals of Nuclear Medicine
Jang Yoo, Hai-Jeon Yoon, Bom Sahn Kim
OBJECTIVE: This study aimed to evaluate the prognostic value of F-18 FDG PET/CT in comparison with Tc-99m sestamibi breast-specific gamma imaging (BSGI) and previously established clinical prognostic parameters of invasive ductal breast carcinoma (IDC). METHODS: We retrospectively included 157 female IDC patients (mean age 49.2 years, range 29.9-78.9) who underwent PET/CT and BSGI. The maximum standardized uptake value (SUVmax) and tumor to normal background ratios (TNRs) of their primary tumors were measured on PET/CT and BSGI, respectively...
September 19, 2016: Annals of Nuclear Medicine
Olivier Lairez, Denis Agostini
No abstract text is available yet for this article.
September 16, 2016: Annals of Nuclear Medicine
Ignasi Carrió, Seigo Kinuya
No abstract text is available yet for this article.
September 16, 2016: Annals of Nuclear Medicine
Jihyun Kim, Jeong-Ok Lee, Jin Ho Paik, Won Woo Lee, Sang Eun Kim, Yoo Sung Song
PURPOSE: Diffuse large B-cell lymphoma (DLBCL) is a pathologically heterogeneous disease with different prognoses according to its molecular profiles. Despite the broad usage of (18)F-fluoro-2-dexoxy-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT), previous studies that have investigated the value of interim (18)F-FDG PET/CT in DLBCL have given the controversial results. The purpose of this study was to evaluate the prognostic value of interim (18)F-FDG PET/CT in DLBCL according to germinal center B cell-like (GCB) and non-GCB molecular profiling...
September 15, 2016: Annals of Nuclear Medicine
Haidong Cai, Yu Qiao, Xiao Huang, Ming Sun, Qiong Luo, Xueyu Yuan, Yuehua Yang, Weiqing Mao, Zhongwei Lv
OBJECTIVE: In the initial assessment of thyroid nodules, thyrotropin (TSH) has very low sensitivity for assessing functional thyroid nodules (FTNs). The false negativity in FTNs and the false positivity in non-FTNs misinterpreted by TSH will raise unnecessary assessment costs. Therefore, the aim of this study is to explore the values of the TSH and color flow Doppler sonography (CFDS) combined strategies in reducing the unnecessary assessment costs. METHODS: 2383 patients with thyroid nodules were retrospectively analyzed, including 107 FTNs and 2276 non-FTNs...
September 13, 2016: Annals of Nuclear Medicine
Hayahiko Fujii, Masashi Nakadate, Hiroaki Tanaka, Naoki Harata, Sayako Oota, Jun Isogai, Katsuya Yoshida
OBJECTIVE: To assess (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) images in primary thyroid lymphoma (PTL) patients before and after treatment. METHODS: We conducted a retrospective review of data for ten patients (four men, six women) of mean age 65 (range 48-88) years, with histopathologically confirmed malignant thyroid lymphoma who underwent pre-treatment and post-treatment (18)F-FDG PET between January 2005 and December 2014...
September 10, 2016: Annals of Nuclear Medicine
Eku Shimosegawa, Kayako Isohashi, Sadahiro Naka, Genki Horitsugi, Jun Hatazawa
OBJECTIVES: In boron neutron capture therapy (BNCT) for cancer, the accurate estimation of (10)B tissue concentrations, especially in neighboring normal organs, is important to avoid adverse effects. The (10)B concentration in normal organs after loading with (10)B, however, has not been established in humans. In this study, we performed 4-borono-2-[(18)F]-fluoro-phenylalanine ((18)FBPA) PET in healthy volunteers and estimated the chronological changes in the (10)B concentrations of normal organs...
September 1, 2016: Annals of Nuclear Medicine
Woo Hee Choi, Yoo Hyun Um, Won Sang Jung, Sung Hoon Kim
OBJECTIVE: The aim of this study was to examine and compare two automated quantitative software tools (PMOD and MIMneuro) for the quantification of amyloid positron emission tomography (PET). METHODS: A total of 30 subjects-15 Alzheimer's disease (AD) patients and 15 cognitively normal age- and sex-matched controls-were enrolled. All subjects underwent structural volumetric magnetic resonance imaging (MRI) and amyloid PET scans with F-18 florbetaben. Regional standardized uptake value ratios (SUVRs) using the cerebellar cortex as a reference region were obtained using PMOD and MIMneuro...
August 27, 2016: Annals of Nuclear Medicine
Naohisa Suzawa, Yasutaka Ichikawa, Masaki Ishida, Yoya Tomita, Ryohei Nakayama, Hajime Sakuma
PURPOSE: To demonstrate the feasibility of respiratory gating during whole-body scan for lung lesions in routine (18)F-FDG PET/CT examinations using a time-of-flight (TOF)-capable scanner to determine the effect of respiratory gating on reduction of both misregistration (between CT and PET) and image blurring, and on improvement of the maximum standardized uptake value (SUVmax). MATERIALS AND METHODS: Patients with lung lesions who received FDG PET/CT were prospectively studied...
August 26, 2016: Annals of Nuclear Medicine
Young-Do Kim, Hyeonseok S Jeong, In-Uk Song, Yong-An Chung, Eun Namgung, Yong-Duk Kim
OBJECTIVE: Although Parkinson's disease (PD) is frequently accompanied by depression, brain perfusion deficits in PD with depression remain unclear. This study aimed to assess alterations in regional cerebral blood flow (rCBF) in depressed PD patients using (99m)Tc hexamethyl-propylene-amine-oxime single-photon emission computed tomography (SPECT). METHODS: Among 78 patients with PD, 35 patients were classified into the depressed PD group, while the rest (43 patients) was assigned to the nondepressed PD group based on the scores of the Geriatric Depressive Scale (GDS)...
August 26, 2016: Annals of Nuclear Medicine
Svetlana I Sazonova, Julia N Ilyushenkova, Yuri B Lishmanov, Roman E Batalov, Alexey E Sazonov, Ludmila A Larionova, Evgeniy A Nesterov, Natalia V Varlamova, Julia V Rogovskaya, Tatyana A Shelkovnikova, Sergey V Popov
OBJECTIVE: Aim was to study the performance of single-photon emission computed tomography (SPECT) with (99m)Tc-pyrophosphate ((99m)Tc-PYP) in diagnostics of chronic latent inflammation in myocardium of patients with atrial fibrillation (AF). METHODS: The research included 70 patients (the average age of 49.3 ± 10.2 years) with persistent form of idiopathic AF. All patients underwent myocardium SPECT with (99m)Tc-PYP and cardiac magnetic resonance imaging (CMR) before the ablation...
August 24, 2016: Annals of Nuclear Medicine
Takayuki Shibutani, Masahisa Onoguchi, Tetsuro Katafuchi, Seigo Kinuya
OBJECTIVE: We developed a novel myocardial phantom and analysis program to standardize using a quantitative index to objectively evaluate the image quality. We aimed to reveal whether our proposed phantom and analysis program are suitable for image standardization. METHODS: An evaluation system of myocardial image based on technical grounds (EMIT) phantom was developed to standardize the image quality of myocardial SPECT and was constructed with the lung and myocardium in the thorax phantom; the myocardial phantom included five normal areas and eight defective areas with four defects in size (5, 10, 15, and 20 mm) and four defects in thickness (10, 7...
August 20, 2016: Annals of Nuclear Medicine
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