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Annals of Nuclear Medicine

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https://www.readbyqxmd.com/read/28220365/binding-of-11-c-pittsburgh-compound-b-correlated-with-white-matter-injury-in-hypertensive-small-vessel-disease
#1
Tetsuya Hashimoto, Chiaki Yokota, Kazuhiro Koshino, Takashi Temma, Makoto Yamazaki, Satoshi Iguchi, Ryo Shimomura, Toshiyuki Uehara, Naoko Funatsu, Tenyu Hino, Kazuo Minematsu, Hidehiro Iida, Kazunori Toyoda
OBJECTIVE: (11)C-Pittsburgh compound-B ((11)C-PIB) positron emission tomography (PET) is used to visualize and quantify amyloid deposition in the brain cortex in pathological conditions such as Alzheimer's disease (AD). Intense (11)C-PIB retention is also observed in the white matter (WM) of both healthy individuals and AD patients. However, the clinical implications of this retention in brain WM have not been clarified. We investigated the relationship between the extent of white matter lesions (WMLs) and the binding potential of (11)C-PIB (BPND) in the WM in patients with hypertensive small vessel disease...
February 20, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28205000/aortic-knob-width-reflects-left-ventricular-diastolic-function-assessed-by-gated-myocardial-perfusion-single-photon-emission-computed-tomography-in-patients-with-normal-myocardial-perfusion
#2
Satoshi Kurisu, Tadanao Higaki, Yoji Sumimoto, Hiroki Ikenaga, Noriaki Watanabe, Ken Ishibashi, Yoshihiro Dohi, Yukihiro Fukuda, Yasuki Kihara
BACKGROUND: Aortic knob width on chest radiography represents the extent of aortic dialation and tortuosity of the aortic arch. We tested the hypothesis that aortic knob width reflected left ventricular (LV) diastolic function assessed by gated myocardial perfusion single photon emission computed tomography (SPECT) in patients with normal myocardial perfusion. METHODS: One hundred and thirty patients with preserved LV ejection fraction and normal myocardial perfusion were enrolled in this study...
February 15, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28197975/research-of-predictive-factors-for-cardiac-resynchronization-therapy-a-prospective-study-comparing-data-from-phase-analysis-of-gated-myocardial-perfusion-single-photon-computed-tomography-and-echocardiography-trying-to-anticipate-response-to-crt
#3
Rémy Gendre, O Lairez, P Mondoly, A Duparc, D Carrié, M Galinier, I Berry, T Cognet
BACKGROUND: Cardiac resynchronization therapy (CRT) reduces morbidity and mortality in chronic systolic heart failure. About 20% of implanted patients are considered as "non-responders". This study aimed to evaluate gated myocardial perfusion single-photon emission computed tomography (GMPS) phase parameters as compared to echocardiography in the assessment of predictors for response to CRT before and after CRT activation. METHODS: Forty-two patients were prospectively included during 15 months...
February 14, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28194701/an-automated-voxel-based-method-for-calculating-the-reference-value-for-a-brain-tumour-metabolic-index-using-18-f-fdg-pet-and-11-c-methionine-pet
#4
Miwako Takahashi, Tsutomu Soma, Akitake Mukasa, Keitaro Koyama, Takuya Arai, Toshimitsu Momose
OBJECTIVE: The tumour-to-normal ratio (T/N) is a representative index reflecting brain tumour activity by (18)F-fluorodeoxyglucose (FDG) and (11)C-methionine (MET) PET. We proposed a new automated method of calculating the normal reference value (N-value) for use as the denomination of T/N. This method uses voxel-based analysis of FDG- and MET-PET images. We compared the results of this method with those of the standard region-of-interest (ROI) method. METHODS: Data sets were obtained from 32 patients with newly diagnosed glioma and 13 patients with recurrent brain tumour...
February 13, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28181119/visual-evaluation-of-kinetic-characteristics-of-pet-probe-for-neuroreceptors-using-a-two-phase-graphic-plot-analysis
#5
Hiroshi Ito, Yoko Ikoma, Chie Seki, Yasuyuki Kimura, Hiroshi Kawaguchi, Hiroyuki Takuwa, Masanori Ichise, Tetsuya Suhara, Iwao Kanno
Objectives In PET studies for neuroreceptors, tracer kinetics are described by the two-tissue compartment model (2-TCM), and binding parameters, including the total distribution volume (V T), non-displaceable distribution volume (V ND), and binding potential (BPND), can be determined from model parameters estimated by kinetic analysis. The stability of binding parameter estimates depends on the kinetic characteristics of radioligands. To describe these kinetic characteristics, we previously developed a two-phase graphic plot analysis in which V ND and V T can be estimated from the x-intercept of regression lines for early and delayed phases, respectively...
February 8, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28181118/brain-uptake-and-safety-of-flutemetamol-f-18-injection-in-japanese-subjects-with-probable-alzheimer-s-disease-subjects-with-amnestic-mild-cognitive-impairment-and-healthy-volunteers
#6
Takami Miki, Hiroyuki Shimada, Jae-Seung Kim, Yasuji Yamamoto, Masakazu Sugino, Hisatomo Kowa, Kerstin Heurling, Michelle Zanette, Paul F Sherwin, Michio Senda
OBJECTIVE: This Phase 2 study assessed the performance of positron emission tomography (PET) brain images made with Flutemetamol F 18 Injection in detecting β-amyloid neuritic plaques in Japanese subjects. METHODS: Seventy subjects (25 with probable Alzheimer's disease (pAD), 20 with amnestic mild cognitive impairment (aMCI), and 25 cognitively normal healthy volunteers[HVs]) underwent PET brain imaging after intravenous Flutemetamol F 18 Injection (185 MBq). Images were interpreted as normal or abnormal for neuritic plaque density by each of five non-Japanese and five Japanese readers who were blinded to clinical data...
February 8, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28168397/clinical-correlation-of-metabolic-parameters-on-18-f-fdg-pet-ct-in-idiopathic-frozen-shoulder
#7
Kyoung Sook Won, Du Hwan Kim, Duk Hyun Sung, Bong-Il Song, Hae Won Kim, Kwang-Soon Song, Si-Wook Lee, Chul-Hyun Cho
OBJECTIVE: Because positron emission tomography/computed tomography (PET/CT) using fluorine-18-fluorodeoxyglucose ((18)F-FDG) can be used to visualize inflammation of the musculoskeletal system, it may help elucidate the pathophysiology of frozen shoulder (FS). The purpose of this study was to characterize the uptake pattern on (18)F-FDG PET/CT in patients with idiopathic FS and to determine if there is a correlation between its metabolic parameters and clinical findings. METHODS: (18)F-FDG PET/CT was conducted to 35 patients with unilateral idiopathic FS...
February 6, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28144811/influence-of-acquisition-orbit-on-phase-analysis-of-gated-single-photon-emission-computed-tomography-myocardial-perfusion-imaging-for-assessment-of-left-ventricular-mechanical-dyssynchrony
#8
Tomofumi Misaka, Makoto Hosono, Takashi Kudo, Takamichi Ito, Tsutomu Syomura, Masanobu Uemura, Kaoru Okajima
OBJECTIVE: The association between left ventricular (LV) dyssynchrony parameters, given by phase analysis of gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI), and acquisition orbits is unclear. The aim of this study was to assess the dependence of LV dyssynchrony parameters on acquisition orbits. METHODS: Ninety-nine patients who underwent (201)Tl-gated SPECT MPI were categorized into minor hypoperfusion or major hypoperfusion groups...
January 31, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27995542/bone-scan-index-of-the-jaw-a-new-approach-for-evaluating-early-stage-anti-resorptive-agents-related-osteonecrosis
#9
Satoru Watanabe, Kenichi Nakajima, Atsushi Mizokami, Hiroshi Yaegashi, Natsuyo Noguchi, Shuichi Kawashiri, Masafumi Inokuchi, Seigo Kinuya
OBJECTIVE: A computer-aided diagnosis of bone scintigraphy using a bone scan index (BSI) has not been applied to a diagnosis of anti-resorptive agents-related osteonecrosis of the jaw (ARONJ). The aim of this study was to validate a diagnostic ability of BSI for early-stage ARONJ. METHODS: A total of 44 cancer patients treated with anti-resorptive drugs were evaluated retrospectively. All patients underwent bone scintigraphy and the tracer uptakes were analyzed by BSI...
December 19, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28012120/improvement-in-automated-quantitation-of-myocardial-perfusion-abnormality-by-using-iterative-reconstruction-image-in-combination-with-resolution-recovery-attenuation-and-scatter-corrections-for-the-detection-of-coronary-artery-disease
#10
Taiki Chono, Masahisa Onoguchi, Takayuki Shibutani, Akiyoshi Hashimoto, Tomoaki Nakata, Naoya Yama, Kazufumi Tsuchihashi, Masamitsu Hatakenaka
OBJECTIVE: An iterative reconstruction method in combination with resolution recovery, attenuation and scatter corrections (IR-RASC) can improve image quality. It, however, is undetermined whether this technique can improve the detection of coronary artery disease (CAD) when automated quantitative analysis is used. This study evaluated diagnostic values of IR-RASC in combination with automated quantitative analysis in stress myocardial perfusion imaging (MPI) in the CAD detection. METHODS: This study enrolled consecutive 64 patients (mean age 66...
February 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28000164/respiratory-average-ct-for-attenuation-correction-in-myocardial-perfusion-spect-ct
#11
Duo Zhang, Bang-Hung Yang, Nien Yun Wu, Greta Seng Peng Mok
OBJECTIVE: Cine average CT (CACT) and interpolated average CT (IACT) have been proposed to improve attenuation correction (AC) for PET/CT in oncologic and cardiac studies. This study aims to evaluate their effectiveness on myocardial perfusion SPECT/CT using computer simulation and physical phantom experiments. METHODS: We first simulated normal male with (99m)Tc-sestamibi distribution using digital XCAT phantom with respiratory motion amplitudes of 2, 3, and 4 cm...
February 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27921286/-18-f-fdg-pet-ct-to-differentiate-malignant-necrotic-lymph-node-from-benign-cystic-lesions-in-the-neck
#12
Peymaneh Abadi, Allan Johansen, Christian Godballe, Oke Gerke, Poul Flemming Høilund-Carlsen, Anders Thomassen
OBJECTIVE: Patients presenting with cystic lesions in the neck without obvious signs of malignancy constitute a diagnostic challenge since fine needle aspiration is often insufficient and a diagnosis may not be reached until surgical resection/biopsy is performed. The differential diagnosis of a cystic cervical mass comprises a variety of benign conditions, but malignancy must be ruled out. We examined the diagnostic performance of fluorine-18 fluorodeoxyglucose ((18)F-FDG) PET/CT to identify malignancy...
February 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27921285/spatiotemporal-distribution-modeling-of-pet-tracer-uptake-in-solid-tumors
#13
Madjid Soltani, Mostafa Sefidgar, Hossein Bazmara, Michael E Casey, Rathan M Subramaniam, Richard L Wahl, Arman Rahmim
OBJECTIVE: Distribution of PET tracer uptake is elaborately modeled via a general equation used for solute transport modeling. This model can be used to incorporate various transport parameters of a solid tumor such as hydraulic conductivity of the microvessel wall, transvascular permeability as well as interstitial space parameters. This is especially significant because tracer delivery and drug delivery to solid tumors are determined by similar underlying tumor transport phenomena, and quantifying the former can enable enhanced prediction of the latter...
February 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27914043/a-revisit-to-quantitative-pet-with-18-f-fdopa-of-high-specific-activity-using-a-high-resolution-condition-in-view-of-application-to-regenerative-therapy
#14
Go Akamatsu, Akihito Ohnishi, Kazuki Aita, Hiroyuki Nishida, Yasuhiko Ikari, Masahiro Sasaki, Nobuo Kohara, Michio Senda
OBJECTIVE: With the advent of regenerative/cell therapy for Parkinson's disease (PD), (18)F-FDOPA has drawn new attention as a biomarker of the therapeutic that cannot be evaluated with radiopharmaceuticals for dopamine transporter. Since most previous (18)F-FDOPA PET studies were carried out many years ago with a PET scanner of lower resolution and with (18)F-FDOPA of low specific activity synthesized from (18)F-F2, we used a newer PET/CT scanner with a high-resolution condition and (18)F-FDOPA synthesized from (18)F-F(-) to re-evaluate this technique on normal subjects and patients with PD, together with D2 receptor imaging with (11)C-raclopride (RAC)...
February 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27885545/optimization-of-scan-initiation-timing-after-11-c-methionine-administration-for-the-diagnosis-of-suspected-recurrent-brain-tumors
#15
Reiko Nakajima, Koichiro Abe, Mitsuru Momose, Kenji Fukushima, Yuka Matsuo, Ken Kimura, Chisato Kondo, Shuji Sakai
OBJECTIVE: (11)C-Methionine (MET) positron emission tomography (PET) imaging is a valuable technique for the evaluation of primary and recurrent brain tumors. Many studies have used MET-PET for data acquisition starting at 20 min after the tracer injection, while others have used scan initiation times at 5-15 min postinjection. No previous studies have identified the best acquisition timing during MET-PET imaging for suspected recurrent brain tumors. Here we sought to determine the optimal scan initiating timing after MET administration for the detection of recurrent brain tumors...
February 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27848160/coronary-flow-reserve-and-relative-flow-reserve-measured-by-n-13-ammonia-pet-for-characterization-of-coronary-artery-disease
#16
Sang-Geon Cho, Ki Seong Park, Jahae Kim, Sae-Ryung Kang, Ho-Chun Song, Ju Han Kim, Jae Yeong Cho, Young Joon Hong, Zeenat Jabin, Hee Jeong Park, Geum-Cheol Jeong, Seong Young Kwon, Jin Chul Paeng, Hyeon Sik Kim, Jung-Joon Min, Ernest V Garcia, Henry Hee-Seung Bom
OBJECTIVE: We evaluated the relationships between coronary flow reserve (CFR) and relative flow reserve (RFR) measured by N-13 ammonia positron emission tomography (PET) for characterization of epicardial coronary artery disease (CAD). METHODS: Sixty-nine consecutive stable angina patients underwent N-13 ammonia PET, coronary computed tomography angiography (CCTA), and if necessary, invasive coronary angiography (CAG) within 2 weeks. Myocardial blood flow (MBF), CFR, RFR, and coronary vascular resistance of the reference arterial territory (CVRref) were measured by N-13 ammonia PET...
February 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27848159/effect-of-chemotherapy-on-the-impact-of-fdg-pet-ct-in-selection-of-patients-for-surgical-resection-of-colorectal-liver-metastases-single-center-analysis-of-pet-cam-randomized-trial
#17
Ur Metser, Jaydeep Halankar, Deanna Langer, Ravi Mohan, Douglas Hussey, Moshonov Hadas, Shlomit Tamir
: The largest randomized controlled trial (RCT) on the effect of FDG-PET on surgical management for metastatic colorectal adenocarcinoma to liver ("PET-CAM") reported only a modest change in surgical management (8%). PURPOSE: To explore the relationship between prior chemotherapy and detection of metastatic disease on PET in patients from PET-CAM. Secondary aim: to determine whether centralized imaging interpretation could have impacted trial results. METHODS: The study included 120 patients from a single institution...
February 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27812791/generating-harmonized-suv-within-the-eanm-earl-accreditation-program-software-approach-versus-earl-compliant-reconstruction
#18
Charline Lasnon, Thibault Salomon, Cédric Desmonts, Pascal Dô, Youssef Oulkhouir, Jeannick Madelaine, Nicolas Aide
BACKGROUND: Evolutions in hardware and software PET technology, such as point spread function (PSF) reconstruction, have been shown to improve diagnostic performance, but can also lead to important device-dependent and reconstruction-dependent variations in standardized uptake values (SUVs). This may preclude the multicentre use of SUVs as a prognostic or diagnostic tool or as a biomarker of the early response to antineoplastic treatments. This study compared two SUV harmonization strategies using a newer reconstruction algorithm that improves lesion detection while maintaining comparability with older systems: (1) the use of a second reconstruction compliant with harmonization standards and (2) the use of a proprietary software tool (EQ...
February 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27804054/regional-myocardial-damage-and-active-inflammation-in-patients-with-cardiac-sarcoidosis-detected-by-non-invasive-multi-modal-imaging
#19
Shohei Kataoka, Mitsuru Momose, Kenji Fukushima, Naoki Serizawa, Atsushi Suzuki, Chisato Kondo, Koichiro Abe, Shuji Sakai, Nobuhisa Hagiwara
AIMS: Cardiac sarcoidosis (CS) can be diagnosed using (18)F-FDG-PET/CT (PET), cardiovascular magnetic resonance (CMR), and (123)I-BMIPP/(201)TlCl dual myocardial SPECT. This study aims to clarify the relationships among the three modalities with respect to CS. METHODS AND RESULTS: We evaluated 16 patients (male n = 11; age 55 ± 13 years) with confirmed CS who underwent PET, CMR, and dual SPECT with gated SPECT before starting steroid therapy. The left ventricular myocardium was divided into 17 segments to obtain SUVmax for PET images, defect scores from 0 to 4 (0 normal; 4 absent), and mismatch scores for dual SPECT (BMDS, TLDS, and MS) images and late gadolinium enhancement (LGE) scores (0 none; 1 partly positive; 2 homogeneous) on CMR images...
February 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27815812/sentinel-node-mapping-in-endometrial-cancer-patients-comparing-spect-ct-gamma-probe-and-dye
#20
COMPARATIVE STUDY
Federica Elisei, Cinzia Crivellaro, Daniela Giuliani, Carlotta Dolci, Elena De Ponti, Luca Montanelli, Maria La Manna, Luca Guerra, Maurizio Arosio, Claudio Landoni, Alessandro Buda
OBJECTIVE: The aim of this study was to compare preoperative SPECT/CT with gamma-probe and methylene blue-dye (MBD) in the identification of sentinel lymph node (SLN) in early stage endometrial cancer. METHODS: 40 stage-I EC patients (66.7 ± 9.7 years) underwent preoperative lymphoscintigraphy. After about 3 h from Tc-99m-albumin nanocolloid cervical injection, all patients underwent SPECT/CT study. MBD was injected into the cervix just before surgery under general anesthesia...
January 2017: Annals of Nuclear Medicine
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