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Annals of Nuclear Medicine

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https://www.readbyqxmd.com/read/29143283/evaluation-of-sequential-spect-and-ct-for-targeted-radionuclide-therapy-dosimetry
#1
Tiantian Li, Nien-Yun Wu, Na Song, Greta S P Mok
PURPOSE: In targeted radionuclide therapy (TRT), a prior knowledge of the absorbed dose biodistribution is essential for pre-therapy treatment planning. Previously, we showed that non-rigid organ-by-organ registration in sequential quantitative SPECT images improved dose estimation. This study aims to investigate if sequential CT can further improve TRT dosimetric accuracy. METHODS: We simulated SPECT/CT acquisitions at 1, 12, 24, 72 and 144 h In-111 Zevalin post-injection using an analytical MEGP projector, modeling attenuation, scatter and collimator-detector response...
November 15, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29134565/prognostic-value-of-fdg-pet-and-dwi-in-breast-cancer
#2
Kazuhiro Kitajima, Yasuo Miyoshi, Toshiko Yamano, Soichi Odawara, Tomoko Higuchi, Koichiro Yamakado
OBJECTIVE: To investigate the prognostic value of preoperative FDG-PET/CT and diffusion weighted imaging (DWI) in patients with breast cancer. METHODS: A total of 73 patients with newly diagnosed invasive breast cancer who had undergone preoperative whole-body FDG-PET/CT and 3-Tesla breast MRI including DWI followed by surgery were identified. Effects of primary tumor PET parameters [maximum standardized uptake value (SUVmax), mean SUV (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG)] and DWI parameters [mean apparent diffusion coefficient (ADCmean) and minimum ADC (ADCmin)] including clinicopathologic factors on disease-free survival (DFS) were retrospectively evaluated using the log-rank and Cox methods...
November 13, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29067547/low-levels-of-psma-expression-limit-the-utility-of-18-f-dcfpyl-pet-ct-for-imaging-urothelial-carcinoma
#3
Scott P Campbell, Alexander S Baras, Mark W Ball, Max Kates, Noah M Hahn, Trinity J Bivalacqua, Michael H Johnson, Martin G Pomper, Mohamad E Allaf, Steven P Rowe, Michael A Gorin
OBJECTIVE: To explore the clinical utility of PSMA-targeted (18)F-DCFPyL PET/CT in patients with metastatic urothelial carcinoma. METHODS: Three patients with metastatic urothelial carcinoma were imaged with (18)F-DCFPyL PET/CT. All lesions with perceptible radiotracer uptake above background were considered positive. Maximum standardized uptake values were recorded for each detected lesion and findings on (18)F-DCFPyL PET/CT were compared to those on conventional imaging studies...
October 24, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29058224/influence-of-region-of-interest-determination-on-measurement-of-signal-to-noise-ratio-in-liver-on-pet-images
#4
Shinji Amakusa, Koki Matsuoka, Masayuki Kawano, Kiyotaka Hasegawa, Mio Ouchida, Ayaka Date, Tsuyoshi Yoshida, Masayuki Sasaki
OBJECTIVE: On (18)F-fluoro-2-deoxy-D-glucose ((18)F-FDG) positron emission tomography (PET), signal-to-noise ratio in the liver (SNRliver) is used as a metric to assess image quality. However, some regions-of-interest (ROIs) are used when measuring the SNRliver. The purpose of this study is to examine the different ROIs and volumes of interest (VOIs) to obtain a reproducible SNRliver. METHODS: This study included 108 patients who underwent (18)F-FDG-PET/CT scans for the purpose of cancer screening...
October 20, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28986773/feasibility-of-combined-risk-stratification-with-coronary-ct-angiography-and-stress-myocardial-spect-in-patients-with-chronic-coronary-artery-disease
#5
Tomonari Kiriyama, Yoshimitsu Fukushima, Hiromitsu Hayashi, Hitoshi Takano, Shin-Ichiro Kumita
OBJECTIVE: To examine the additional prognostic value of coronary CT angiography (CTA) over myocardial perfusion imaging (MPI) in patients with suspected or known coronary artery disease. METHODS: A series of 157 patients (mean age 69 ± 9 years; 76% male; median follow-up 49 months; range 12-82 months) underwent stress MPI with SPECT and coronary CTA within a 6-month interval. Summed stress score (SSS) and summed difference score (SDS) of stress MPI, number of vessels with stenosis, and presence of left main trunk stenosis and high-risk plaques on coronary CTA were examined...
October 6, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28986764/predictive-and-prognostic-value-of-18f-dopa-pet-ct-in-patients-affected-by-recurrent-medullary-carcinoma-of-the-thyroid
#6
Federico Caobelli, Agostino Chiaravalloti, Laura Evangelista, Giorgio Saladini, Orazio Schillaci, Manuela Vadrucci, Federica Scalorbi, Davide Donner, Pierpaolo Alongi
INTRODUCTION: Medullary thyroid carcinoma (MTC) is a malignancy accounting for about 5-8% of thyroid cancers. Serum calcitonin and carcinoembryonic antigen (CEA) levels are widely used to monitor disease progression. However, prognostic factors able to predict outcomes are highly desirable. We, therefore, aimed to assess the prognostic role of (18)F-DOPA PET/CT in patients with recurrent MTC. MATERIALS AND METHODS: 60 patients (mean age 64 ± 13 years, range 44-82) with recurrent MTC were eligible from a multicenter database...
October 6, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28975586/impact-of-treatment-delay-in-radium-223-therapy-of-metastatic-castration-resistant-prostate-cancer-patients
#7
Marie Øbro Fosbøl, Peter Meidahl Petersen, Gedske Daugaard, Søren Holm, Andreas Kjaer, Jann Mortensen
BACKGROUND: Radium-223-dichloride (Ra-223) is an alpha-emitting, bone seeking radionuclide therapy approved for patients with metastatic castration-resistant prostate cancer (mCRPC). In the fall of 2014, a global temporary shortage of Ra-223 occurred for 2 months due to production irregularities. The aim of this study was to assess whether prolonged interval between Ra-223 cycles to non-disease related causes had a negative impact on clinical outcome of therapy. MATERIALS AND METHODS: Retrospective single-center study of mCRPC patients who initiated Ra-223 therapy in the period from March 2014 to February 2015...
October 3, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28936780/ct-based-spect-attenuation-correction-and-assessment-of-infarct-size-results-from-a-cardiac-phantom-study
#8
Alexander Stephan Kroiss, Stephan Gerhard Nekolla, Georg Dobrozemsky, Thomas Grubinger, Barry Lynn Shulkin, Markus Schwaiger
RATIONALE: Myocardial perfusion SPECT is a commonly performed, well established, clinically useful procedure for the management of patients with coronary artery disease. However, the attenuation of photons from myocardium impacts the quantification of infarct sizes. CT-Attenuation Correction (AC) potentially resolves this problem. This contention was investigated by analyzing various parameters for infarct size delineation in a cardiac phantom model. METHODS: A thorax phantom with a left ventricle (LV), fillable defects, lungs, spine and liver was used...
September 21, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28913731/inter-and-intra-observer-reproducibility-of-quantitative-analysis-for-fp-cit-spect-in-patients-with-dlb
#9
Atsutaka Okizaki, Michihiro Nakayama, Kaori Nakajima, Takayuki Katayama, Takahiro Uno, Fumiyoshi Morikawa, Juichiro Naoe, Koji Takahashi
BACKGROUND: Dopamine transporter single photon emission CT (DAT-SPECT) is useful in the evaluation of dementia with Lewy bodies (DLB). The specific binding ratio (SBR) is an index to measure DAT density. However, poorly reproducible cases are occasionally experienced in clinical practice. We hypothesized that distance-weighted histogram (DWH) may be useful to improve the reproducibility of SBR. The purpose of this study was to investigate inter- and intra-observer reproducibility of SBR with conventional and DWH methods, and to visually evaluate the precision in reference voxel of interest (VOI) definition using these methods...
September 14, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28905201/assessment-of-intratumor-heterogeneity-in-mesenchymal-uterine-tumor-by-an-18-f-fdg-pet-ct-texture-analysis
#10
Tetsuya Tsujikawa, Makoto Yamamoto, Kunihiro Shono, Shizuka Yamada, Hideaki Tsuyoshi, Yasushi Kiyono, Hirohiko Kimura, Hidehiko Okazawa, Yoshio Yoshida
OBJECTIVE: The aim of this study was to retrospectively evaluate the clinical significance of (18)F-FDG PET/CT textural features for discriminating uterine sarcoma from leiomyoma. METHODS: Fifty-five patients with suspected uterine sarcoma based on ultrasound and MRI findings who underwent pretreatment (18)F-FDG PET/CT were included. Fifteen patients were histopathologically proven to have uterine sarcoma, 14 patients by surgical operation and one by biopsy, and 40 patients were diagnosed with leiomyoma by surgical operation or in a follow-up for at least 2 years...
September 13, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28895066/the-effect-of-short-term-treatment-with-lithium-carbonate-on-the-outcome-of-radioiodine-therapy-in-patients-with-long-lasting-graves-hyperthyroidism
#11
Vladan Sekulić, Milena Rajić, Marina Vlajković, Slobodan Ilić, Miloš Stević, Marko Kojić
OBJECTIVE: The outcome of radioiodine therapy (RIT) in Graves' hyperthyroidism (GH) mainly depends on radioiodine ((131)I) uptake and the effective half-life of (131)I in the gland. Studies have shown that lithium carbonate (LiCO3) enhances the (131)I half-life and increases the applied thyroid radiation dose without affecting the thyroid (131)I uptake. We investigated the effect of short-term treatment with LiCO3 on the outcome of RIT in patients with long-lasting GH, its influence on the thyroid hormones levels 7 days after RIT, and possible side effects...
September 11, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28887761/textural-features-and-suv-based-variables-assessed-by-dual-time-point-18f-fdg-pet-ct-in-locally-advanced-breast-cancer
#12
Ana María Garcia-Vicente, David Molina, Julián Pérez-Beteta, Mariano Amo-Salas, Alicia Martínez-González, Gloria Bueno, María Jesús Tello-Galán, Ángel Soriano-Castrejón
AIM: To study the influence of dual time point 18F-FDG PET/CT in textural features and SUV-based variables and their relation among them. METHODS: Fifty-six patients with locally advanced breast cancer (LABC) were prospectively included. All of them underwent a standard 18F-FDG PET/CT (PET-1) and a delayed acquisition (PET-2). After segmentation, SUV variables (SUVmax, SUVmean, and SUVpeak), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were obtained...
September 8, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28887599/uptake-of-av-1451-in-meningiomas
#13
Tyler J Bruinsma, Derek R Johnson, Ping Fang, Matthew Senjem, Keith A Josephs, Jennifer L Whitwell, Bradley F Boeve, Mukesh K Pandey, Kejal Kantarci, David T Jones, Prashanthi Vemuri, Melissa Murray, Jonathan Graff-Radford, Christopher G Schwarz, David S Knopman, Ronald C Petersen, Clifford R Jack, Val J Lowe
AIM: AV-1451 is an imaging agent labeled with the positron-emitting radiolabel Fluorine-18. 18F-AV-1451 binds paired helical filament tau (PHF-tau), a pathology related to Alzheimer's disease. In our study of AV-1451 uptake in the brains of cognitively normal subjects, we noted a case of a meningioma with visually significant uptake of AV-1451. OBJECTIVE: We initiated the present retrospective study to further examine cases of meningioma that underwent AV-1451 imaging...
September 8, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28864931/bone-metastases-from-breast-cancer-associations-between-morphologic-ct-patterns-and-glycolytic-activity-on-pet-and-bone-scintigraphy-as-well-as-explorative-search-for-influential-factors
#14
Tsutomu Sugihara, Mitsuru Koizumi, Masamichi Koyama, Takashi Terauchi, Naoya Gomi, Yoshinori Ito, Kiyohiko Hatake, Naohiro Sata
BACKGROUND: This study aimed to compare the detection of bone metastases from breast cancer on F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) and bone scintigraphy (BS). An explorative search for factors influencing the sensitivity or uptake of BS and FDG-PET was also performed. METHODS: Eighty-eight patients with bone metastases from breast cancer were eligible for this study. Histological confirmation of bone metastases was obtained in 31 patients...
September 1, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28940141/iq%C3%A2-spect-technology-and-its-clinical-applications-using-multicenter-normal-databases
#15
REVIEW
Kenichi Nakajima, Koichi Okuda, Mitsuru Momose, Shinro Matsuo, Chisato Kondo, Masayoshi Sarai, Takayuki Shibutani, Masahisa Onoguchi, Takeshi Shimizu, A Hans Vija
IQ·SPECT (Siemens Medical Solutions) is a solution for high-sensitivity and short-time acquisition imaging of the heart for a variable angle general purpose gamma camera. It consists of a multi-focal collimator, a cardio-centric orbit and advanced iterative reconstruction, modeling the image formation physics accurately. The multi-focal collimator enables distance-dependent enlargement of the center region while avoiding truncation at the edges. With the specified configuration and a cardio-centric orbit it can obtain a fourfold sensitivity increase for the heart at the center of the scan orbit...
November 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28900854/relationships-between-serum-psa-levels-gleason-scores-and-results-of-68ga-psmapet-ct-in-patients-with-recurrent-prostate-cancer
#16
Yasemin Sanli, Serkan Kuyumcu, Oner Sanli, Fikret Buyukkaya, Ayça İribaş, Goksel Alcin, Emin Darendeliler, Yasemin Ozluk, Sevda Ozel Yildiz, Cüneyt Turkmen
AIM: To investigate the relationship between serum PSA level, Gleason score of PCa and the outcomes of Ga(68)-PSMA PET/CT in patients with recurrent PCa. METHODS: A total of 109 consecutive patients (median age 71 years; range 48-89 years) who had PSA recurrence after RP and/or hormonotherapy and/or radiotherapy were included in this study. Local recurrences, lymph node metastasis (pelvic, abdominal and/or supradiaphragmatic), bone metastases (oligometastatic/multimetastatic) and other metastatic sites (lung, liver, brain, etc) were documented...
November 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28879528/effects-of-chronic-kidney-disease-on-myocardial-washout-rate-of-thallium-201-in-patients-with-normal-myocardial-perfusion-on-single-photon-emission-computed-tomography
#17
Satoshi Kurisu, Yoji Sumimoto, Hiroki Ikenaga, Ken Ishibashi, Yukihiro Fukuda, Yasuki Kihara
BACKGROUND: Myocardial perfusion single photon emission computed tomography (SPECT) is often performed even in patients with chronic kidney disease (CKD). We assessed the effects of CKD on myocardial washout rate (WR) of thallium (Tl)-201 in patients with normal myocardial perfusion on SPECT. METHODS: Two hundred and fifty-six patients with normal myocardial perfusion were enrolled in this study. CKD was defined as estimated glomerular filtration rate (eGFR) <60 ml/min/1...
November 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28831739/patterns-of-uptake-of-prostate-specific-membrane-antigen-psma-targeted-18-f-dcfpyl-in-peripheral-ganglia
#18
Rudolf A Werner, Sara Sheikhbahaei, Krystyna M Jones, Mehrbod S Javadi, Lilja B Solnes, Ashley E Ross, Mohamad E Allaf, Kenneth J Pienta, Constantin Lapa, Andreas K Buck, Takahiro Higuchi, Martin G Pomper, Michael A Gorin, Steven P Rowe
OBJECTIVE: Radiotracers targeting prostate-specific membrane antigen (PSMA) have increasingly been recognized as showing uptake in a number of normal structures, anatomic variants, and non-prostate-cancer pathologies. We aimed to explore the frequency and degree of uptake in peripheral ganglia in patients undergoing PET with the PSMA-targeted agent (18)F-DCFPyL. METHODS: A total of 98 patients who underwent (18)F-DCFPyL PET/CT imaging were retrospectively analyzed...
November 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28815452/-18-f-fdg-pet-radiomics-approaches-comparing-and-clustering-features-in-cervical-cancer
#19
COMPARATIVE STUDY
Tetsuya Tsujikawa, Tasmiah Rahman, Makoto Yamamoto, Shizuka Yamada, Hideaki Tsuyoshi, Yasushi Kiyono, Hirohiko Kimura, Yoshio Yoshida, Hidehiko Okazawa
OBJECTIVES: The aims of our study were to find the textural features on (18)F-FDG PET/CT which reflect the different histological architectures between cervical cancer subtypes and to make a visual assessment of the association between (18)F-FDG PET textural features in cervical cancer. METHODS: Eighty-three cervical cancer patients [62 squamous cell carcinomas (SCCs) and 21 non-SCCs (NSCCs)] who had undergone pretreatment (18)F-FDG PET/CT were enrolled. A texture analysis was performed on PET/CT images, from which 18 PET radiomics features were extracted including first-order features such as standardized uptake value (SUV), metabolic tumor volume (MTV) and total lesion glycolysis (TLG), second- and high-order textural features using SUV histogram, normalized gray-level co-occurrence matrix (NGLCM), and neighborhood gray-tone difference matrix, respectively...
November 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28815414/comparison-of-image-quality-between-step-and-shoot-and-continuous-bed-motion-techniques-in-whole-body-18-f-fluorodeoxyglucose-positron-emission-tomography-with-the-same-acquisition-duration
#20
COMPARATIVE STUDY
Shozo Yamashita, Haruki Yamamoto, Tetsu Nakaichi, Tatsuya Yoneyama, Kunihiko Yokoyama
OBJECTIVE: This study aimed to compare the qualities of whole-body positron emission tomography (PET) images acquired by the step-and-shoot (SS) and continuous bed motion (CBM) techniques with approximately the same acquisition duration, through phantom and clinical studies. METHODS: A body phantom with 10-37 mm spheres was filled with (18)F-fluorodeoxyglucose (FDG) solution at a sphere-to-background radioactivity ratio of 4:1 and acquired by both techniques. Reconstructed images were evaluated by visual assessment, percentages of contrast (%Q H) and background variability (%N) in accordance with the Japanese guideline for oncology FDG-PET/computed tomography (CT)...
November 2017: Annals of Nuclear Medicine
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