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Annals of Nuclear Medicine

Masayuki Inubushi, Mitsuaki Tatsumi, Yuka Yamamoto, Katsuhiko Kato, Tetsuya Tsujikawa, Ryuichi Nishii
Written by associate editors of the Annals of Nuclear Medicine, this invited review article is intended to offer our readers a condensed global view on the high-quality research work that has been published in Europe last year. We have divided this article into five sections. The first three sections from the oncology category include "[18 F]fluorodeoxyglucose (FDG) positron-emission tomography (PET) for therapy monitoring in malignant lymphoma", "[18 F]fluoromisonidazole (FMISO) PET for hypoxia", and "lymphoscintigraphy update"...
September 21, 2018: Annals of Nuclear Medicine
Yuji Nakamoto, Takayoshi Ishimori, Kohei Sano, Yoichi Shimizu, Kaori Togashi
OBJECTIVE: Positron emission tomography (PET)/computed tomography (CT) using 68 Ga-labeled 1,4,7,10-tetraazacyclododecane-N,N',N″,N‴-tetraacetic acid-D-Phe1 -Tyr3 -octreotide (DOTATOC) is usually performed about 1-h post-injection; however, because of rapid blood clearance, the waiting time for scanning could possibly be shortened without affecting diagnostic performance. The purpose of this study was to investigate the feasibility of early scanning at 30 min post-injection. METHODS: Thirty-eight patients who underwent DOTATOC-PET/CT were analyzed...
September 20, 2018: Annals of Nuclear Medicine
Xavier Palard-Novello, Luc Beuzit, Giulio Gambarota, Florence Le Jeune, Etienne Garin, Pierre-Yves Salaün, Anne Devillers, Solène Querellou, Patrick Bourguet, Hervé Saint-Jalmes
AIM: 18 F-Choline (FCH) uptake parameters are strong indicators of aggressive disease in prostate cancer. Functional parameters derived by magnetic resonance imaging (MRI) are also correlated to aggressive disease. The aim of this work was to evaluate the relationship between metabolic parameters derived by FCH PET/CT and functional parameters derived by MRI. MATERIALS AND METHODS: Fourteen patients with proven prostate cancer who underwent FCH PET/CT and multiparametric MRI were enrolled...
September 15, 2018: Annals of Nuclear Medicine
Hoda Anwar, Thomas J Vogl, Mahasen A Abougabal, Frank Grünwald, Peter Kleine, Sherif Elrefaie, Nour-Eldin A Nour-Eldin
OBJECTIVE: Administration of postoperative chemotherapy to patients with completely resected stage I NSCLC is still a matter of debate. The aim of the present study was to evaluate the value of different baseline 18 F-FDG PET parameters in identifying surgical stage I NSCLC patients who are at high risk of recurrence, and thus are indicated for further postoperative treatment. METHODS: This is a retrospective study, which included 49 patients (28 males, 21 females) with the median age of 69 years (range 28-84), who had pathologically proven stage I NSCLC...
September 15, 2018: Annals of Nuclear Medicine
Ningning Lv, Shi Gao, Lin Bai, Bin Ji, Jinru Xue, Xiaoguang Ge, Bin Chen
BACKGROUND: Our study was designed to compare the diagnostic efficacies of integrated 99m Tc-HYNIC-PEG4-E[PEG4-c(RGDfK)]2 (99m Tc-3PRGD2 ) single-photon emission computed tomography (SPECT) images and computed tomography (CT) images in lymph node metastasis in the patients with esophageal cancer. METHODS: From September 2015 and May 2018, 32 patients with histologically proven primary esophageal carcinoma underwent both 99m Tc-3PRGD2 SPECT and CT scans followed by esophagectomy with lymph node dissection...
September 14, 2018: Annals of Nuclear Medicine
Junyan Xu, Yi Li, Silong Hu, Linjun Lu, Zhiqi Gao, Huiyu Yuan
OBJECTS: The purpose was to evaluate the correlation of the pre-treatment hematological parameters with metabolic parameters of primary tumor in baseline 18 F-FDG PET/CT in patients with colorectal cancer (CRC) and estimate the prognostic value of both. METHODS: We retrospectively investigated 231 patients with CRC who underwent baseline 18 F-FDG PET/CT. Routine blood sampling was tested in the same term. PET parameters in term of hematological parameters and pathological characteristics of primary tumor were compared...
September 14, 2018: Annals of Nuclear Medicine
Tomoka Kitao, Tohru Shiga, Kenji Hirata, Mitsunori Sekizawa, Toshiki Takei, Katsushige Yamashiro, Nagara Tamaki
INTRODUCTION: Soft-tissue sarcomas (STS) are rare types of tumors that have variable levels of tumor differentiation. F-18 fluorodeoxyglucose positron emission tomography (FDG PET) has been established as an useful tool for STS patients, and the metabolic tumor volume (MTV) and total lesion glycolysis (TLG) are reported to be useful in various cancers. We compared the diagnostic value of four PET parameters (maximum standardized uptake value [SUVmax], SUVmean, MTV, and TLG) from two acquisition timings for predicting the expression of the pathological marker of cell proliferation Ki-67, based on pathological investigation...
September 8, 2018: Annals of Nuclear Medicine
Rouaa Beshr, Kayako Isohashi, Tadashi Watabe, Sadahiro Naka, Genki Horitsugi, Victor Romanov, Hiroki Kato, Shin-Ichi Miyatake, Eku Shimosegawa, Jun Hatazawa
OBJECTIVES: A previous study reported that a differential diagnosis between glioblastoma progression and radiation necrosis by 4-borono-2-[18 F]-fluoro-phenylalanine ([18 F]FBPA) PET can be made based on lesion-to-normal ratio of [18 F]FBPA accumulation. Two-dimensional data acquisition mode PET alone system, with in-plane resolution of 7.9 mm and axial resolution of 13.9 mm, was used. In the current study, we aimed to confirm the differential diagnostic capability of [18 F]FBPA PET/CT with higher PET spatial resolution by three-dimensional visual inspection and by measuring mean standardized uptake value (SUVmean), maximum SUV (SUVmax), metabolic tumor volume (MTV), and total lesion (TL) [18 F]FBPA uptake...
September 7, 2018: Annals of Nuclear Medicine
Sophia I Koukouraki, Adam A Hatzidakis, Ioanna Mitrouska, Maria I Stathaki, Kostas Perisinakis
OBJECTIVE: Acute pulmonary embolism (PE) is a life-threatening disorder with high mortality. A prompt diagnosis and treatment is essential for reducing the mortality rate. The purpose of the study is to evaluate if lung perfusion scintigraphy (LPS) continues to have a role in the clinical management of patients suspected of pulmonary embolism in the CT pulmonary angiography (CTPA) era. METHODS: For this study, 1183 patients who had been subjected to LPS were retrospectively evaluated and classified into the following groups: A (positive LPS), B (negative LPS) and C (indeterminate LPS)...
September 3, 2018: Annals of Nuclear Medicine
Ismet Sarikaya, Prem Sharma, Ali Sarikaya
OBJECTIVE: Bone-specific radiotracers are known to accumulate in breast lesions. Tc-99m diphosphonates have been widely studied in differentiating breast lesions. In this retrospective study, we aimed to assess the uptake of the bone-specific PET radiotracer, F-18 fluoride (NaF), in primary breast cancers to determine its sensitivity and to identify any differences in NaF uptake between calcified and non-calcified tumors, histological subtypes, and patients with or without axillary lymphadenopathy...
September 3, 2018: Annals of Nuclear Medicine
Yusuke Inoue, Toshimasa Hara, Tomomi Ikari, Keita Takahashi, Hiroki Miyatake, Yutaka Abe
OBJECTIVE: With the advancement of reperfusion therapy in stroke patients, assessment of perfusion status after therapy is gaining importance. Hyperperfusion tends to be underestimated by the conventional early imaging of 123 I-IMP brain perfusion SPECT. We evaluated the utility of super-early imaging as an adjunct to early imaging for the assessment of postischemic hyperperfusion in stroke patients. METHODS: Sixty-seven patients who underwent 123 I-IMP brain perfusion SPECT within 14 days after the onset of cerebral infarction were retrospectively analyzed...
September 1, 2018: Annals of Nuclear Medicine
Varvara Valotassiou, Julia Malamitsi, John Papatriantafyllou, Efthimios Dardiotis, Ioannis Tsougos, Dimitrios Psimadas, Sotiria Alexiou, George Hadjigeorgiou, Panagiotis Georgoulias
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. Beta-amyloid (Aβ) deposition and neurofibrillary tangles (NFTs) of abnormal hyperphosphorylated tau protein are the pathological hallmarks of the disease, accompanied by other pathological processes such as microglia activation. Functional and molecular nuclear medicine imaging with single-photon emission computed tomography (SPECT) and positron emission tomography (PET) techniques provides valuable information about the underlying pathological processes, many years before the appearance of clinical symptoms...
August 20, 2018: Annals of Nuclear Medicine
Yukako Nakanishi, Kazuhiro Kitajima, Yusuke Yamada, Takahiko Hashimoto, Toru Suzuki, Shuken Go, Akihiro Kanematsu, Michio Nojima, Koichiro Yamakado, Shingo Yamamoto
PURPOSE: To compare findings obtained with 11 C-choline and FDG PET/CT scanning for renal cell carcinoma staging and restaging. MATERIALS AND METHODS: Twenty-eight renal cell carcinoma patients whose histological subtype was clear cell type in 26 and papillary type in 2, while Fuhrman nuclear grade was G1,2 in 16 and G3,4 in 12, underwent both 11 C-choline and FDG PET/CT examinations before (n = 10) and/or after (n = 18) treatment, then those scanning modalities were compared in regard to patient- and lesion-based diagnostic performance using 5 grading scores...
August 17, 2018: Annals of Nuclear Medicine
Rudolf A Werner, Ralph A Bundschuh, Lena Bundschuh, Mehrbod S Javadi, Takahiro Higuchi, Alexander Weich, Sara Sheikhbahaei, Kenneth J Pienta, Andreas K Buck, Martin G Pomper, Michael A Gorin, Constantin Lapa, Steven P Rowe
Both prostate-specific membrane antigen (PSMA)- and somatostatin receptor (SSTR)-targeted positron emission tomography (PET)-based imaging agents for prostate carcinoma and neuroendocrine tumors, respectively, are seeing rapidly expanding use. In addition to diagnostic applications, both classes of radiotracers can be used to triage patients for theranostic endoradiotherapy. While interpreting PSMA- or SSTR-targeted PET/computed tomography (CT) scans, the reader has to be aware of certain pitfalls. Adding to the complexity of the interpretation of those imaging agents, both normal biodistribution, and also false-positive and -negative findings differ between PSMA- and SSTR-targeted PET radiotracers...
August 14, 2018: Annals of Nuclear Medicine
Malte Kircher, Peter Herhaus, Margret Schottelius, Andreas K Buck, Rudolf A Werner, Hans-Jürgen Wester, Ulrich Keller, Constantin Lapa
Given its prominent role in inflammation and cancer biology, the C-X-C motif chemokine receptor 4 (CXCR4) has gained a lot of attention in the recent years. This review gives a short overview of the physiology and pathology of chemokines and chemokine receptors and then focuses on the current experience of targeting CXCR4, using radiolabeled receptor ligands suitable for positron emission tomography (PET) imaging, in both hematologic and solid malignancy as well as in inflammatory conditions. Additionally, CXCR4-directed endoradiotherapy (ERT) as a new treatment option is discussed...
August 13, 2018: Annals of Nuclear Medicine
Sangwon Han, Hyesung Kim, Yeon Joo Kim, Chong Hyun Suh, Sungmin Woo
OBJECTIVE: To perform a systematic review and meta-analysis on the prognostic value of 18 F-FDG PET-derived volume-based parameters regarding metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in patients with ovarian cancer. METHODS: Pubmed and EMBASE databases were searched up to February 12, 2018 for studies which evaluated MTV or TLG as a prognostic factor in ovarian cancer with progression-free (PFS) and overall survival (OS) as the endpoints. Hazard ratios (HRs) were meta-analytically pooled using the random-effects model...
August 12, 2018: Annals of Nuclear Medicine
Jang Yoo, Bom Sahn Kim, Hai-Jeon Yoon
OBJECTIVE: This study aimed to demonstrate the clinical significance of total lesion glycolysis (TLG) of primary breast cancer using 18 F-FDG PET/CT to predict axillary lymph node (ALN) metastasis in invasive ductal breast cancer (IDC) with a clinically negative axillary lymph node (cN-ALN). METHODS: 135 patients, newly diagnosed with IDC with C N-ALN between July 2016 and October 2017, were retrospectively enrolled. We estimated primary tumor PET/CT parameters including the maximum standard uptake value (SUVmax ), metabolic tumor volume (MTV), and TLG, as well as clinicopathologic findings...
August 9, 2018: Annals of Nuclear Medicine
Michael J Seider, Stephanie L Pugh, Corey Langer, Gwen Wyatt, William Demas, Afshin Rashtian, Cathy L Clausen, Jerome David Derdel, Sean F Cleary, Christopher A Peters, Ashok Ramalingam, James E Clarkson, Michael Tomblyn, Rachel A Rabinovitch, Lisa A Kachnic, Lawrence B Berk
BACKGROUND: Skeletal-related events (SREs), common sequelae of metastatic cancer, are reduced by bisphosphonates. In this study, it was postulated that radiopharmaceuticals, added to bisphosphonates, could further decrease the incidence of SREs. METHODS: NRG Oncology RTOG 0517 randomized patients with breast, lung, and prostate cancer and blastic bone metastases to either zoledronic acid (ZA) alone or ZA plus radiopharmaceuticals (Sr-89 or Sm-153). The primary endpoint was time to development of SREs...
August 9, 2018: Annals of Nuclear Medicine
Akihiko Takahashi, Shingo Baba, Masayuki Sasaki
OBJECTIVE: Radium-223 (223 Ra) is used in unsealed radionuclide therapy for metastatic bone tumors. The aim of this study is to apply a computational model observer to 223 Ra planar images, and to assess the performance of collimators in 223 Ra imaging. METHODS: The 223 Ra planar images were created via an in-house Monte Carlo simulation code using HEXAGON and NAI modules. The phantom was a National Electrical Manufacturers Association body phantom with a hot sphere...
August 2, 2018: Annals of Nuclear Medicine
Roberto A Escala Cornejo, Paloma García-Talavera, Miguel Navarro Martin, Berta Pérez López, María García Muñoz, Ma Pilar Tamayo Alonso, Juan J Cruz Hernández
Large cell neuroendocrine carcinoma of the lung (LCNEC) is a high-grade, poorly differentiated tumor that typically does not express somatostatin receptors. Thus, it does not benefit from treatment with somatostatin analogs and peptide receptor radionuclide therapy (PRRT). The current study objective was to demonstrate that treatment with PRRT may be a valid option in neuroendocrine carcinomas with high expression of somatostatin receptors. This is a case report of a 58-year-old man who was diagnosed with LCNEC and received chemotherapy treatment with little benefit...
July 26, 2018: Annals of Nuclear Medicine
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