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Annals of Nuclear Medicine

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https://www.readbyqxmd.com/read/29774458/effects-of-rs591323-on-serotonin-transporter-availability-in-healthy-male-subjects
#1
Kyoungjune Pak, Hyun-Yeol Nam, Seunghyeon Shin, Keunyoung Kim, Myung Jun Lee, Eun-Joo Kim, Jae Meen Lee, Seong-Jang Kim, In Joo Kim
OBJECTIVES: We aimed to investigate the association between genetic factors of SNPs dopamine transporter (DAT) and serotonin transporter (SERT) availabilities in healthy controls. METHODS: The study population consisted of healthy controls with screening 123 I-FP-CIT single-photon emission computed tomography. Specific binding of 123 I-FP-CIT regarding DAT and SERT was calculated using a region of interest analysis. VOI template was applied to measure specific binding ratios (SBRs) of caudate nucleus, putamen, striatum, midbrain, and pons...
May 17, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29766463/predictive-factors-for-the-outcomes-of-initial-i-131-low-dose-ablation-therapy-to-japanese-patients-with-differentiated-thyroid-cancer
#2
Shinji Ito, Shingo Iwano, Katsuhiko Kato, Shinji Naganawa
OBJECTIVE: To identify prognostic factors associated with a low-iodine diet (LID) and the amount of remnant thyroid tissue in Japanese patients with differentiated thyroid cancer (DTC) who received initial I-131 remnant ablation (RAI) using a fixed low dose of I-131 (1110 MBq). PATIENTS AND METHODS: In this prospective study, we enrolled 45 patients. Patients were classified into a self-managed LID group and a strict LID group. We measured the urinary iodine concentration on the day of RAI after patients consumed LID for 2 weeks...
May 15, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29754276/-718-f-fdg-pet-ct-metabolic-tumor-parameters-and-radiomics-features-in-aggressive-non-hodgkin-s-lymphoma-as-predictors-of-treatment-outcome-and-survival
#3
Aatif Parvez, Noam Tau, Douglas Hussey, Manjula Maganti, Ur Metser
PURPOSE: To determine whether metabolic tumor parameters and radiomic features extracted from 18 F-FDG PET/CT (PET) can predict response to therapy and outcome in patients with aggressive B-cell lymphoma. METHODS: This institutional ethics board-approved retrospective study included 82 patients undergoing PET for aggressive B-cell lymphoma staging. Whole-body metabolic tumor volume (MTV) using various thresholds and tumor radiomic features were assessed on representative tumor sites...
May 12, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29730823/the-correlation-between-striatal-and-cortical-binding-ratio-of-11-c-pib-pet-in-amyloid-uptake-positive-patients
#4
Julia Sauerbeck, Kazunari Ishii, Chisa Hosokawa, Hayato Kaida, Franziska T Scheiwein, Kohei Hanaoka, Axel Rominger, Matthias Brendel, Peter Bartenstein, Takamichi Murakami
PURPOSE: In subjects with amyloid deposition, striatal accumulation of 11 C-Pittsburgh compound B (PiB) demonstrated by positron emission tomography (PET) is related to the stage of Alzheimer's disease (AD). In this study, we investigated the correlation between striatal and cortical non-displaceable binding potential (BPND ). METHODS: Seventy-three subjects who complained of cognitive disturbance underwent dynamic PiB-PET studies and showed positive PiB accumulation were retrospectively selected...
May 5, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29713999/implications-of-electrocardiographic-frontal-qrs-axis-on-left-ventricular-diastolic-parameters-derived-from-electrocardiogram-gated-myocardial-perfusion-single-photon-emission-computed-tomography
#5
Satoshi Kurisu, Kazuhiro Nitta, Yoji Sumimoto, Hiroki Ikenaga, Ken Ishibashi, Yukihiro Fukuda, Yasuki Kihara
BACKGROUND: Current electrocardiographic (ECG) machines report various variables including frontal QRS axis automatically. We tested the hypothesis that QRS axis is associated with left ventricular (LV) diastolic parameters derived from ECG-gated myocardial perfusion single photon emission computed tomography (SPECT) independent of myocardial ischemia. METHODS: Ninety-three patients with preserved LV ejection fraction and no evidence of myocardial ischemia were enrolled based on ECG-gated SPECT...
April 30, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29667143/diagnostic-performance-of-18-f-fdg-pet-ct-and-whole-body-diffusion-weighted-imaging-with-background-body-suppression-dwibs-in-detection-of-lymph-node-and-bone-metastases-from-pediatric-neuroblastoma
#6
Hiroaki Ishiguchi, Shinji Ito, Katsuhiko Kato, Yusuke Sakurai, Hisashi Kawai, Naotoshi Fujita, Shinji Abe, Atsushi Narita, Nobuhiro Nishio, Hideki Muramatsu, Yoshiyuki Takahashi, Shinji Naganawa
OBJECTIVE: Recent many studies have shown that whole body "diffusion-weighted imaging with background body signal suppression" (DWIBS) seems a beneficial tool having higher tumor detection sensitivity without ionizing radiation exposure for pediatric tumors. In this study, we evaluated the diagnostic performance of whole body DWIBS and 18 F-FDG PET/CT for detecting lymph node and bone metastases in pediatric patients with neuroblastoma. METHODS: Subjects in this retrospective study comprised 13 consecutive pediatric patients with neuroblastoma (7 males, 6 females; mean age, 2...
April 17, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29654576/quantitative-evaluation-of-the-tracer-distribution-in-dopamine-transporter-spect-for-objective-interpretation
#7
Yu Iwabuchi, Tadaki Nakahara, Masashi Kameyama, Yoshitake Yamada, Masahiro Hashimoto, Yuji Ogata, Yohji Matsusaka, Mari Katagiri, Kazunari Itoh, Takashi Osada, Daisuke Ito, Hajime Tabuchi, Masahiro Jinzaki
PURPOSE: Quantification of the tracer distribution would add objectivity to the visual assessments of dopamine transporter (DAT) single photon emission computed tomography (SPECT) data. Our study aimed to evaluate the diagnostic utility of fractal dimension (FD) as a quantitative indicator of tracer distribution and compared with the conventional quantitative value: specific binding ratio (SBR). We also evaluated the utility of the combined index SBR/FD (SBR divided by FD). MATERIALS AND METHODS: We conducted both clinical and phantom studies...
April 13, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29651757/comparison-of-125-i-and-111-in-labeled-peptide-probes-for-in-vivo-detection-of-oxidized-low-density-lipoprotein-in-atherosclerotic-plaques
#8
Takashi Temma, Naoya Kondo, Keiko Yoda, Kantaro Nishigori, Satoru Onoe, Masashi Shiomi, Masahiro Ono, Hideo Saji
OBJECTIVE: Oxidized low-density lipoprotein (OxLDL) plays a pivotal role in atherosclerotic plaque destabilization, which suggests its potential as a nuclear medical imaging target. We previously developed radioiodinated 125 I-AHP7, a peptide probe carrying a 7-residue sequence from the OxLDL-binding protein Asp-hemolysin, for specific OxLDL imaging. Although 125 I-AHP7 recognized OxLDL, it had low stability. Thus, to improve stability, we designed radiolabeled 22-residue peptide probes, 125 I-AHP22 and 111 In-AHP22, which include the entire AHP7 sequence, and evaluated the stability, activity, and applications of these probes in vitro and in vivo...
April 12, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29564718/implementation-of-gpu-accelerated-spect-reconstruction-with-monte-carlo-based-scatter-correction
#9
Tobias Bexelius, Antti Sohlberg
OBJECTIVE: Statistical SPECT reconstruction can be very time-consuming especially when compensations for collimator and detector response, attenuation, and scatter are included in the reconstruction. This work proposes an accelerated SPECT reconstruction algorithm based on graphics processing unit (GPU) processing. METHODS: Ordered subset expectation maximization (OSEM) algorithm with CT-based attenuation modelling, depth-dependent Gaussian convolution-based collimator-detector response modelling, and Monte Carlo-based scatter compensation was implemented using OpenCL...
March 21, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29560563/diagnostic-value-of-quantitative-assessment-of-cardiac-18-f-fluoro-2-deoxyglucose-uptake-in-suspected-cardiac-sarcoidosis
#10
Adrien Lebasnier, Damien Legallois, Boris Bienvenu, Emmanuel Bergot, Cédric Desmonts, Gérard Zalcman, Denis Agostini, Alain Manrique
OBJECTIVE: The identification of cardiac sarcoidosis is challenging as there is no gold standard consensually admitted for its diagnosis. The aim of this study was to evaluate the diagnostic value of the assessment of cardiac dynamic 18 F-fluoro-2-deoxyglucose positron emission tomography (18 F-FDG PET/CT) and net influx constant (Ki) in patients suspected of cardiac sarcoidosis. METHODS: Data obtained from 30 biopsy-proven sarcoidosis patients suspected of cardiac sarcoidosis who underwent a 50-min list-mode cardiac dynamic 18 F-FDG PET/CT after a 24 h high-fat and low-carbohydrate diet were analyzed...
March 20, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29556945/ct-based-attenuation-correction-and-resolution-compensation-for-i-123-imp-brain-spect-normal-database-a-multicenter-phantom-study
#11
Yoshitaka Inui, Takashi Ichihara, Masaki Uno, Masanobu Ishiguro, Kengo Ito, Katsuhiko Kato, Hajime Sakuma, Hidehiko Okazawa, Hiroshi Toyama
OBJECTIVE: Statistical image analysis of brain SPECT images has improved diagnostic accuracy for brain disorders. However, the results of statistical analysis vary depending on the institution even when they use a common normal database (NDB), due to different intrinsic spatial resolutions or correction methods. The present study aimed to evaluate the correction of spatial resolution differences between equipment and examine the differences in skull bone attenuation to construct a common NDB for use in multicenter settings...
March 19, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29556944/predictive-significance-of-breast-specific-gamma-imaging-for-upstaging-core-needle-biopsy-detected-ductal-carcinoma-in-situ-to-invasive-cancer
#12
Jang Yoo, Bom Sahn Kim, Hai-Jeon Yoon
OBJECTIVE: We evaluated the significance of breast-specific gamma imaging (BSGI) for determination of upstaging to invasive cancer from preoperative ductal carcinoma in situ (DCIS). METHODS: This study enrolled 168 patients with 175 breast lesions diagnosed as DCIS on core-needle biopsy that subsequently underwent preoperative BSGI between September 2011 and October 2017. Both qualitative and quantitative analyses using tumor-to-normal background ratio (TNR) and coefficient of variation (COV) were performed, and the predictive significance for upstaging to invasive cancer was investigated...
March 19, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29516390/artificial-neural-network-retrained-to-detect-myocardial-ischemia-using-a-japanese-multicenter-database
#13
Kenichi Nakajima, Koichi Okuda, Satoru Watanabe, Shinro Matsuo, Seigo Kinuya, Karin Toth, Lars Edenbrandt
PURPOSE: An artificial neural network (ANN) has been applied to detect myocardial perfusion defects and ischemia. The present study compares the diagnostic accuracy of a more recent ANN version (1.1) with the initial version 1.0. METHODS: We examined 106 patients (age, 77 ± 10 years) with coronary angiographic findings, comprising multi-vessel disease (≥ 50% stenosis) (52%) or old myocardial infarction (27%), or who had undergone coronary revascularization (30%)...
March 7, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29546633/improvement-in-the-measurement-error-of-the-specific-binding-ratio-in-dopamine-transporter-spect-imaging-due-to-exclusion-of-the-cerebrospinal-fluid-fraction-using-the-threshold-of-voxel-ri-count
#14
Sunao Mizumura, Kazuhiro Nishikawa, Akihiro Murata, Kosei Yoshimura, Nobutomo Ishii, Tadashi Kokubo, Miyako Morooka, Akiko Kajiyama, Atsuro Terahara
OBJECTIVE: In Japan, the Southampton method for dopamine transporter (DAT) SPECT is widely used to quantitatively evaluate striatal radioactivity. The specific binding ratio (SBR) is the ratio of specific to non-specific binding observed after placing pentagonal striatal voxels of interest (VOIs) as references. Although the method can reduce the partial volume effect, the SBR may fluctuate due to the presence of low-count areas of cerebrospinal fluid (CSF), caused by brain atrophy, in the striatal VOIs...
May 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29492810/comparison-of-choline-influx-from-dynamic-18-f-choline-pet-ct-and-clinicopathological-parameters-in-prostate-cancer-initial-assessment
#15
Xavier Palard-Novello, Anne-Lise Blin, David Bourhis, Etienne Garin, Pierre-Yves Salaün, Anne Devillers, Solène Querellou, Patrick Bourguet, Florence Le Jeune, Hervé Saint-Jalmes
AIM: The aim of the study was to compare the kinetic analysis of 18 F-labeled choline (FCH) uptake with static analysis and clinicopathological parameters in patients with newly diagnosed prostate cancer (PC). MATERIALS AND METHODS: Sixty-one patients were included. PSA was performed few days before FCH PET/CT. Gleason scoring (GS) was collected from systematic sextant biopsies. FCH PET/CT consisted in a dual phase: early pelvic list-mode acquisition (from 0 to10 min post-injection) and late whole-body acquisition (60 min post-injection)...
May 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29488161/role-of-pet-mri-in-oral-cavity-and-oropharyngeal-cancers-based-on-the-8th-edition-of-the-ajcc-cancer-staging-system-a-pictorial-essay
#16
Tetsuya Tsujikawa, Norihiko Narita, Masafumi Kanno, Tetsuji Takabayashi, Shigeharu Fujieda, Hidehiko Okazawa
The American Joint Committee on Cancer (AJCC) released the 8th edition of the AJCC cancer staging manual in 2017 that includes significant modifications from the 7th edition in the sections on oral cavity cancer (OCC) and oropharyngeal cancer (OPC). These highlights comprise the incorporation of the depth of invasion and exclusion of extrinsic tongue muscle involvement in the T staging of OCC, the separation of OPC staging based on the high-risk human papilloma virus status, and the inclusion of extranodal extension in N staging...
May 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29478216/the-feasibility-of-18-f-fes-and-18-f-fdg-micropet-ct-for-early-monitoring-the-effect-of-fulvestrant-on-sensitizing-docetaxel-by-downregulating-er%C3%AE-in-er%C3%AE-breast-cancer
#17
Shuai Liu, Bingxin Gu, Jianping Zhang, Yongping Zhang, Xiaoping Xu, Huiyu Yuan, Yingjian Zhang, Zhongyi Yang
OBJECTIVE: Our study aimed to investigate the feasibility of PET/CT for monitoring the influence of fulvestrant on sensitizing docetaxel by downregulating ERα in ERα+ breast cancer. METHODS: Docetaxel-insensitive ERα+ breast cancer cells (DIS-ZR751) were established, identified and cultured. ERα expression, toxicity and viability of DIS-ZR751 were analyzed before and after treatment in vitro. DIS-ZR751-bearing nude mice were randomly divided into four groups according to different treatments: blank (DIS-ZR751), docetaxel (DIS-ZR751+DOC), fulvestrant (DIS-ZR751+FUL), and combination treatment (DIS-ZR751+DOC+FUL)...
May 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29468487/-68-ga-dotatate-pet-ct-imaging-in-carotid-body-paragangliomas
#18
Duygu Has Şimşek, Yasemin Şanlı, Serkan Kuyumcu, Bora Başaran, Ayşe Mudun
OBJECTIVE: The aim of this study was to present our experience in the baseline evaluation of carotid body paragangliomas (CBP) with 68 Ga-DOTATATE PET-CT. METHODS: Five patients (4F, 1M; age 24-73 years) with CBPs who underwent 68 Ga-DOTATATE PET-CT scan before the treatment were evaluated retrospectively. PET-CT images were analyzed visually as well as semiquantitatively, with measurement of maximum standardized uptake value (SUVmax ). RESULTS: All patients had unilateral CBP lesion, showed intense 68 Ga-DOTATATE uptake in PET-CT...
May 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29453681/-18-f-fpybf-2-a-new-f-18-labelled-amyloid-imaging-pet-tracer-biodistribution-and-radiation-dosimetry-assessment-of-first-in-man-18-f-fpybf-2-pet-imaging
#19
Ryuichi Nishii, Tatsuya Higashi, Shinya Kagawa, Chio Okuyama, Yoshihiko Kishibe, Masaaki Takahashi, Tomoko Okina, Norio Suzuki, Hiroshi Hasegawa, Yasuhiro Nagahama, Koichi Ishizu, Naoya Oishi, Hiroyuki Kimura, Hiroyuki Watanabe, Masahiro Ono, Hideo Saji, Hiroshi Yamauchi
OBJECTIVE: Recently, a benzofuran derivative for the imaging of β-amyloid plaques, 5-(5-(2-(2-(2-18 F-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)- N-methylpyridin-2-amine (18 F-FPYBF-2) has been validated as a tracer for amyloid imaging and it was found that 18 F-FPYBF-2 PET/CT is a useful and reliable diagnostic tool for the evaluation of AD (Higashi et al. Ann Nucl Med, https://doi.org/10.1007/s12149-018-1236-1 , 2018). The aim of this study was to assess the biodistribution and radiation dosimetry of diagnostic dosages of 18 F-FPYBF-2 in normal healthy volunteers as a first-in-man study...
May 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29453680/prognostic-implications-of-62-cu-diacetyl-bis-n-4-methylthiosemicarbazone-pet-ct-in-patients-with-glioma
#20
Akira Toriihara, Makoto Ohtake, Kensuke Tateishi, Ayako Hino-Shishikura, Tomohiro Yoneyama, Yoshio Kitazume, Tomio Inoue, Nobutaka Kawahara, Ukihide Tateishi
OBJECTIVE: The potential of positron emission tomography/computed tomography using 62 Cu-diacetyl-bis (N4 -methylthiosemicarbazone) (62 Cu-ATSM PET/CT), which was originally developed as a hypoxic tracer, to predict therapeutic resistance and prognosis has been reported in various cancers. Our purpose was to investigate prognostic value of 62 Cu-ATSM PET/CT in patients with glioma, compared to PET/CT using 2-deoxy-2-[18 F]fluoro-D-glucose (18 F-FDG). METHOD: 56 patients with glioma of World Health Organization grade 2-4 were enrolled...
May 2018: Annals of Nuclear Medicine
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