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Evaluation and In Vitro Study of an Electrospun Bone Tissue Membrane for Bone Regeneration: A Novel Perspective.
Curēus 2024 January
Objectives In the present study, electrospun bone tissue membrane (EBTM) was prepared using polyvinylidene fluoride (PVDF), gelatin (gel), and demineralized bone matrix (DBM) by electrospinning method for its potential application in bone tissue regeneration. Materials and methods The prepared EBTM was evaluated using high-resolution scanning electron microscopy (HR-SEM), energy-dispersive X-ray spectroscopy (EDX; Silicon Drift 2017, USA), thermogravimetric analysis (TGA), and mechanical properties such as tensile strength (MPa), elongation at break (%), flexibility (%), and water absorption (%). In vitro bioactivity testing of EBTM using simulated body fluid (SBF) was performed after 14 days of immersion. Cell viability was tested using human osteoblast-like cells (MG-63) to prove biocompatibility. Results EBTM had superior surface morphology, thermal stability, and mechanical strength. The mechanical properties of EBTM were promising, enabling its use in tissue engineering. Bioactivity test showed that the EBTM surface developed calcium (Ca) and phosphate (P) after 14 days of being immersed in SBF. Additionally, a biocompatibility investigation revealed that EBTM was covered with more viable cells. Conclusion EBTM with sufficient mechanical strength, thermal stability, surface morphology, Ca deposition, and biocompatibility could serve as a plausible material for bone tissue engineering (skin, ligament, cartilage, and bone).
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