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Gut

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https://www.readbyqxmd.com/read/28336518/bmp-9-interferes-with-liver-regeneration-and-promotes-liver-fibrosis
#1
Katja Breitkopf-Heinlein, Christoph Meyer, Courtney König, Haristi Gaitantzi, Annalisa Addante, Maria Thomas, Eliza Wiercinska, Chen Cai, Qi Li, Fengqi Wan, Claus Hellerbrand, Nektarios A Valous, Maximilian Hahnel, Christian Ehlting, Johannes G Bode, Stephanie Müller-Bohl, Ursula Klingmüller, Jutta Altenöder, Iryna Ilkavets, Marie-José Goumans, Lukas J A C Hawinkels, Se-Jin Lee, Matthias Wieland, Carolin Mogler, Matthias P Ebert, Blanca Herrera, Hellmut Augustin, Aránzazu Sánchez, Steven Dooley, Peter Ten Dijke
OBJECTIVE: Bone morphogenetic protein (BMP)-9, a member of the transforming growth factor-β family of cytokines, is constitutively produced in the liver. Systemic levels act on many organs and tissues including bone and endothelium, but little is known about its hepatic functions in health and disease. DESIGN: Levels of BMP-9 and its receptors were analysed in primary liver cells. Direct effects of BMP-9 on hepatic stellate cells (HSCs) and hepatocytes were studied in vitro, and the role of BMP-9 was examined in acute and chronic liver injury models in mice...
March 23, 2017: Gut
https://www.readbyqxmd.com/read/28325746/dietary-emulsifiers-directly-alter-human-microbiota-composition-and-gene-expression-ex-vivo-potentiating-intestinal-inflammation
#2
Benoit Chassaing, Tom Van de Wiele, Jana De Bodt, Massimo Marzorati, Andrew T Gewirtz
OBJECTIVE: The intestinal microbiota plays a central role in the development of many chronic inflammatory diseases including IBD and metabolic syndrome. Administration of substances that alter microbiota composition, including the synthetic dietary emulsifiers polysorbate 80 (P80) and carboxymethylcellulose (CMC), can promote such inflammatory disorders. However, that inflammation itself impacts microbiota composition has obfuscated defining the extent to which these compounds or other substances act directly upon the microbiota versus acting on host parameters that promote inflammation, which subsequently reshapes the microbiota...
March 21, 2017: Gut
https://www.readbyqxmd.com/read/28320770/high-bmi-in-late-adolescence-predicts-future-severe-liver-disease-and-hepatocellular-carcinoma-a-national-population-based-cohort-study-in-1-2-million-men
#3
Hannes Hagström, Per Tynelius, Finn Rasmussen
OBJECTIVE: A high body mass index (BMI) is associated with an increased risk for severe liver disease. It is unclear if this risk differs across BMI categories, and if the association is partially attributed to development of type 2 diabetes mellitus (T2DM). DESIGN: We used register data from more than 1.2 million Swedish men enlisted for conscription between 1969 and 1996. Data regarding new events of severe liver disease and T2DM during follow-up were obtained by record-linkage of population-based registers...
March 20, 2017: Gut
https://www.readbyqxmd.com/read/28320769/in-vitro-and-in-silico-evidence-against-a-significant-effect-of-the-spink1-c-194g-a-variant-on-pre-mrna-splicing
#4
LETTER
Hao Wu, Arnaud Boulling, David N Cooper, Zhao-Shen Li, Zhuan Liao, Jian-Min Chen, Claude Férec
No abstract text is available yet for this article.
March 20, 2017: Gut
https://www.readbyqxmd.com/read/28320768/race-specific-differences-in-mucosal-sulfidogenic-bacteria-modify-colon-cancer-risk
#5
James Kinross
No abstract text is available yet for this article.
March 20, 2017: Gut
https://www.readbyqxmd.com/read/28314736/re-evaluation-of-the-role-of-lumen-apposing-metal-stents-lams-for-pancreatic-%C3%AF-uid-collection-drainage
#6
LETTER
Huiyun Zhu, Han Lin, Zhendong Jin, Yiqi Du
No abstract text is available yet for this article.
March 17, 2017: Gut
https://www.readbyqxmd.com/read/28314735/non-alcoholic-fatty-liver-disease-and-its-relationship-with-cardiovascular-disease-and-other-extrahepatic-diseases
#7
REVIEW
Leon A Adams, Quentin M Anstee, Herbert Tilg, Giovanni Targher
Key physiological functions of the liver, including glucose and lipid metabolism, become disturbed in the setting of non-alcoholic fatty liver disease (NAFLD) and may be associated with a systemic inflammatory 'milieu' initiated in part by liver-secreted cytokines and molecules. Consequently, the pathophysiological effects of NAFLD extend beyond the liver with a large body of clinical evidence demonstrating NAFLD to be independently associated with both prevalent and incident cardiovascular disease (CVD), chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM)...
March 17, 2017: Gut
https://www.readbyqxmd.com/read/28298354/determinants-of-reflux-induced-chronic-cough
#8
Thomas V K Herregods, Ans Pauwels, Jafar Jafari, Daniel Sifrim, Albert J Bredenoord, Jan Tack, André J P M Smout
OBJECTIVE: Gastro-oesophageal reflux is considered to be an important contributing factor in chronic unexplained cough. It remains unclear why some reflux episodes in the same patient causes cough while others do not. To understand more about the mechanism by which reflux induces cough, we aimed to identify factors which are important in triggering cough. DESIGN: In this multicentre study, 49 patients with reflux-associated chronic cough were analysed using 24-hour pH-impedance-pressure monitoring...
March 15, 2017: Gut
https://www.readbyqxmd.com/read/28283539/identification-of-an-epithelial-member-of-the-protease-family-supporting-the-potential-diagnostic-and-therapeutic-role-of-serine-proteases-in-ibs
#9
https://www.readbyqxmd.com/read/28274999/tumour-activated-neutrophils-in-gastric-cancer-foster-immune-suppression-and-disease-progression-through-gm-csf-pd-l1-pathway
#10
Ting-Ting Wang, Yong-Liang Zhao, Liu-Sheng Peng, Na Chen, Weisan Chen, Yi-Pin Lv, Fang-Yuan Mao, Jin-Yu Zhang, Ping Cheng, Yong-Sheng Teng, Xiao-Long Fu, Pei-Wu Yu, Gang Guo, Ping Luo, Yuan Zhuang, Quan-Ming Zou
OBJECTIVE: Neutrophils are prominent components of solid tumours and exhibit distinct phenotypes in different tumour microenvironments. However, the nature, regulation, function and clinical relevance of neutrophils in human gastric cancer (GC) are presently unknown. DESIGN: Flow cytometry analyses were performed to examine levels and phenotype of neutrophils in samples from 105 patients with GC. Kaplan-Meier plots for overall survival were performed using the log-rank test...
March 8, 2017: Gut
https://www.readbyqxmd.com/read/28274998/faecal-microbiota-transplantation-in-clinical-practice
#11
LETTER
E M Terveer, Y H van Beurden, A Goorhuis, C J J Mulder, E J Kuijper, J J Keller
No abstract text is available yet for this article.
March 8, 2017: Gut
https://www.readbyqxmd.com/read/28274997/what-if-prometheus-had-steatosis-potential-use-of-fgf19-to-promote-regeneration-of-the-fatty-liver
#12
Philip M Brown, Yaron Rotman
No abstract text is available yet for this article.
March 8, 2017: Gut
https://www.readbyqxmd.com/read/28274996/activation-of-protease-activated-receptor-4-of-mast-cells-could-downregulate-proinflammatory-cytokines-in-irritable-bowel-syndrome
#13
LETTER
Shuhong An, Guofang Zong, Zhaojin Wang, Juan Shi, Hui Du, Jiangong Hu
No abstract text is available yet for this article.
March 8, 2017: Gut
https://www.readbyqxmd.com/read/28258134/senp1-promotes-hypoxia-induced-cancer-stemness-by-hif-1%C3%AE-desumoylation-and-senp1-hif-1%C3%AE-positive-feedback-loop
#14
Chun-Ping Cui, Carmen Chak-Lui Wong, Alan Ka-Lun Kai, Daniel Wai-Hung Ho, Eunice Yuen-Ting Lau, Yu-Man Tsui, Lo-Kong Chan, Tan-To Cheung, Kenneth Siu-Ho Chok, Albert C Y Chan, Regina Cheuk-Lam Lo, Joyce Man-Fong Lee, Terence Kin-Wah Lee, Irene Oi Lin Ng
OBJECTIVE: We investigated the effect and mechanism of hypoxic microenvironment and hypoxia-inducible factors (HIFs) on hepatocellular carcinoma (HCC) cancer stemness. DESIGN: HCC cancer stemness was analysed by self-renewal ability, chemoresistance, expression of stemness-related genes and cancer stem cell (CSC) marker-positive cell population. Specific small ubiquitin-like modifier (SUMO) proteases 1 (SENP1) mRNA level was examined with quantitative PCR in human paired HCCs...
March 3, 2017: Gut
https://www.readbyqxmd.com/read/28258133/a-novel-p-ser282pro-cpa1-variant-is-associated-with-autosomal-dominant-hereditary-pancreatitis
#15
LETTER
Aleksandra A Kujko, Dorottya M Berki, Grzegorz Oracz, Karolina Wejnarska, Justyna Antoniuk, Katarzyna Wertheim-Tysarowska, Elwira Kołodziejczyk, Jerzy Bal, Miklós Sahin-Tóth, Agnieszka M Rygiel
No abstract text is available yet for this article.
March 3, 2017: Gut
https://www.readbyqxmd.com/read/28246312/interleukin-13-mediated-colitis-in-the-absence-of-il-4r%C3%AE-signalling
#16
LETTER
Jennifer C Hoving, Antony J Cutler, Mosiuoa Leeto, William G C Horsnell, Benjamin G Dewals, Natalie E Nieuwenhuizen, Frank Brombacher
No abstract text is available yet for this article.
February 28, 2017: Gut
https://www.readbyqxmd.com/read/28246311/selective-loxl2-inhibition-potent-antifibrotic-effects-in-ongoing-fibrosis-and-fibrosis-regression
#17
Fernando Magdaleno, Jonel Trebicka
No abstract text is available yet for this article.
February 28, 2017: Gut
https://www.readbyqxmd.com/read/28235905/juan-rod%C3%A3-s-a-successful-and-extraordinary-life-of-a-visionary-hepatologist
#18
Albert Pares
No abstract text is available yet for this article.
February 24, 2017: Gut
https://www.readbyqxmd.com/read/28232475/tears-of-colonoscopy
#19
Michael McFarlane, Ben Disney, Jayne Eaden
No abstract text is available yet for this article.
February 23, 2017: Gut
https://www.readbyqxmd.com/read/28232474/no-difference-in-emergency-department-visits-before-and-after-transition-for-coeliac-disease
#20
LETTER
Norelle R Reilly, Peter H R Green, Jonas F Ludvigsson
No abstract text is available yet for this article.
February 23, 2017: Gut
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