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Gut

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https://www.readbyqxmd.com/read/28108468/metabolic-biomarker-signature-to-differentiate-pancreatic-ductal-adenocarcinoma-from-chronic-pancreatitis
#1
Julia Mayerle, Holger Kalthoff, Regina Reszka, Beate Kamlage, Erik Peter, Bodo Schniewind, Sandra González Maldonado, Christian Pilarsky, Claus-Dieter Heidecke, Philipp Schatz, Marius Distler, Jonas A Scheiber, Ujjwal M Mahajan, F Ulrich Weiss, Robert Grützmann, Markus M Lerch
OBJECTIVE: Current non-invasive diagnostic tests can distinguish between pancreatic cancer (pancreatic ductal adenocarcinoma (PDAC)) and chronic pancreatitis (CP) in only about two thirds of patients. We have searched for blood-derived metabolite biomarkers for this diagnostic purpose. DESIGN: For a case-control study in three tertiary referral centres, 914 subjects were prospectively recruited with PDAC (n=271), CP (n=282), liver cirrhosis (n=100) or healthy as well as non-pancreatic disease controls (n=261) in three consecutive studies...
January 20, 2017: Gut
https://www.readbyqxmd.com/read/28104632/visceral-hypersensitivity-is-associated-with-gi-symptom-severity-in-functional-gi-disorders-consistent-findings-from-five-different-patient-cohorts
#2
Magnus Simrén, Hans Törnblom, Olafur S Palsson, Miranda A L van Tilburg, Lukas Van Oudenhove, Jan Tack, William E Whitehead
OBJECTIVE: Our aim was to evaluate the association between visceral hypersensitivity and GI symptom severity in large cohorts of patients with functional GI disorder (FGID) and to adjust for psychological factors and general tendency to report symptoms. DESIGN: We included five cohorts of patients with FGIDs (IBS or functional dyspepsia; n=1144), who had undergone visceral sensitivity testing using balloon distensions (gastric fundus, descending colon or rectum) and completed questionnaires to assess GI symptom severity, non-GI somatic symptoms, anxiety and depression...
January 19, 2017: Gut
https://www.readbyqxmd.com/read/28100646/targeting-the-correct-target-in-hcc
#3
Carmen Berasain, André Lechel
No abstract text is available yet for this article.
January 18, 2017: Gut
https://www.readbyqxmd.com/read/28096305/epithelial-expression-and-function-of-trypsin-3-in-irritable-bowel-syndrome
#4
Claire Rolland-Fourcade, Alexandre Denadai-Souza, Carla Cirillo, Cintya Lopez, Josue Obed Jaramillo, Cleo Desormeaux, Nicolas Cenac, Jean-Paul Motta, Muriel Larauche, Yvette Taché, Pieter Vanden Berghe, Michel Neunlist, Emmanuel Coron, Sylvain Kirzin, Guillaume Portier, Delphine Bonnet, Laurent Alric, Stephen Vanner, Celine Deraison, Nathalie Vergnolle
OBJECTIVES: Proteases are key mediators of pain and altered enteric neuronal signalling, although the types and sources of these important intestinal mediators are unknown. We hypothesised that intestinal epithelium is a major source of trypsin-like activity in patients with IBS and this activity signals to primary afferent and enteric nerves and induces visceral hypersensitivity. DESIGN: Trypsin-like activity was determined in tissues from patients with IBS and in supernatants of Caco-2 cells stimulated or not...
January 17, 2017: Gut
https://www.readbyqxmd.com/read/28087657/european-consensus-conference-on-faecal-microbiota-transplantation-in-clinical-practice
#5
Giovanni Cammarota, Gianluca Ianiro, Herbert Tilg, Mirjana Rajilić-Stojanović, Patrizia Kump, Reetta Satokari, Harry Sokol, Perttu Arkkila, Cristina Pintus, Ailsa Hart, Jonathan Segal, Marina Aloi, Luca Masucci, Antonio Molinaro, Franco Scaldaferri, Giovanni Gasbarrini, Antonio Lopez-Sanroman, Alexander Link, Pieter de Groot, Willem M de Vos, Christoph Högenauer, Peter Malfertheiner, Eero Mattila, Tomica Milosavljević, Max Nieuwdorp, Maurizio Sanguinetti, Magnus Simren, Antonio Gasbarrini
Faecal microbiota transplantation (FMT) is an important therapeutic option for Clostridium difficile infection. Promising findings suggest that FMT may play a role also in the management of other disorders associated with the alteration of gut microbiota. Although the health community is assessing FMT with renewed interest and patients are becoming more aware, there are technical and logistical issues in establishing such a non-standardised treatment into the clinical practice with safety and proper governance...
January 13, 2017: Gut
https://www.readbyqxmd.com/read/28082319/delayed-severe-bleeding-complications-after-treatment-of-pancreatic-fluid-collections-with-lumen-apposing-metal-stents
#6
LETTER
S S Stecher, P Simon, S Friesecke, A Glitsch, J P Kühn, M M Lerch, J Mayerle
No abstract text is available yet for this article.
January 12, 2017: Gut
https://www.readbyqxmd.com/read/28082318/response-to-letter-to-the-editor
#7
LETTER
Ji Young Bang, Shyam Varadarajulu
No abstract text is available yet for this article.
January 12, 2017: Gut
https://www.readbyqxmd.com/read/28082317/colorectal-cancer-cells-use-the-negative-feedback-regulators-of-wnt-signalling-to-activate-epithelial-mesenchymal-transition-pathways
#8
Eugene Tulchinsky
No abstract text is available yet for this article.
January 12, 2017: Gut
https://www.readbyqxmd.com/read/28082316/mir-16-and-mir-125b-are-involved-in-barrier-function-dysregulation-through-the-modulation-of-claudin-2-and-cingulin-expression-in-the-jejunum-in-ibs-with-diarrhoea
#9
Cristina Martínez, Bruno K Rodiño-Janeiro, Beatriz Lobo, Megan L Stanifer, Bernd Klaus, Martin Granzow, Ana M González-Castro, Eloisa Salvo-Romero, Carmen Alonso-Cotoner, Marc Pigrau, Ralph Roeth, Gudrun Rappold, Wolfgang Huber, Rosa González-Silos, Justo Lorenzo, Inés de Torres, Fernando Azpiroz, Steeve Boulant, María Vicario, Beate Niesler, Javier Santos
OBJECTIVE: Micro-RNAs (miRNAs) play a crucial role in controlling intestinal epithelial barrier function partly by modulating the expression of tight junction (TJ) proteins. We have previously shown differential messenger RNA (mRNA) expression correlated with ultrastructural abnormalities of the epithelial barrier in patients with diarrhoea-predominant IBS (IBS-D). However, the participation of miRNAs in these differential mRNA-associated findings remains to be established. Our aims were (1) to identify miRNAs differentially expressed in the small bowel mucosa of patients with IBS-D and (2) to explore putative target genes specifically involved in epithelial barrier function that are controlled by specific dysregulated IBS-D miRNAs...
January 12, 2017: Gut
https://www.readbyqxmd.com/read/28077438/fibroblast-drug-scavenging-increases-intratumoural-gemcitabine-accumulation-in-murine-pancreas-cancer
#10
E Hessmann, M S Patzak, L Klein, N Chen, V Kari, I Ramu, T E Bapiro, K K Frese, A Gopinathan, F M Richards, D I Jodrell, C Verbeke, X Li, R Heuchel, J M Löhr, S A Johnsen, T M Gress, V Ellenrieder, A Neesse
OBJECTIVE: Desmoplasia and hypovascularity are thought to impede drug delivery in pancreatic ductal adenocarcinoma (PDAC). However, stromal depletion approaches have failed to show clinical responses in patients. Here, we aimed to revisit the role of the tumour microenvironment as a physical barrier for gemcitabine delivery. DESIGN: Gemcitabine metabolites were analysed in LSL-Kras(G12D/+); LSL-Trp53(R172H/+); Pdx-1-Cre (KPC) murine tumours and matched liver metastases, primary tumour cell lines, cancer-associated fibroblasts (CAFs) and pancreatic stellate cells (PSCs) by liquid chromatography-mass spectrometry/mass spectrometry...
January 10, 2017: Gut
https://www.readbyqxmd.com/read/28073893/the-caecal-mucus-sign
#11
Jason Behary, Jason Minco Hui
No abstract text is available yet for this article.
January 10, 2017: Gut
https://www.readbyqxmd.com/read/28073892/socioeconomic-and-ethnic-inequities-within-organised-colorectal-cancer-screening-programmes-worldwide
#12
C M de Klerk, S Gupta, E Dekker, M L Essink-Bot
OBJECTIVE: Colorectal cancer (CRC) screening programmes can reduce CRC mortality. However, the implementation of a screening programme may create or exacerbate socioeconomic and ethnic health inequities if participation varies by subgroup. We determined which organised programmes characterise participation inequities by socioeconomic and ethnic subgroups, and assessed the variation in subgroup participation among programmes collecting group-specific data. DESIGN: Employing a literature review and survey among leaders of national or regional screening programmes, this study identified published and unpublished data on participation by socioeconomic status and ethnicity...
January 10, 2017: Gut
https://www.readbyqxmd.com/read/28073891/vedolizumab-safety-in-pregnancy-and-newborn-outcomes
#13
LETTER
Mette Julsgaard, Jens Kjeldsen, Daniel C Baumgart
No abstract text is available yet for this article.
January 10, 2017: Gut
https://www.readbyqxmd.com/read/28073890/pancreatic-cancer-cell-lines-as-patient-derived-avatars-genetic-characterisation-and-functional-utility
#14
Erik S Knudsen, Uthra Balaji, Brian Mannakee, Paris Vail, Cody Eslinger, Christopher Moxom, John Mansour, Agnieszka K Witkiewicz
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is a therapy recalcitrant disease with the worst survival rate of common solid tumours. Preclinical models that accurately reflect the genetic and biological diversity of PDAC will be important for delineating features of tumour biology and therapeutic vulnerabilities. DESIGN: 27 primary PDAC tumours were employed for genetic analysis and development of tumour models. Tumour tissue was used for derivation of xenografts and cell lines...
January 10, 2017: Gut
https://www.readbyqxmd.com/read/28073889/toward-chronic-hepatitis-c-eradication-in-hiv-positive-patients-including-those-cirrhotic-and-infected-with-genotype-3-viruses
#15
LETTER
Amélie Menard, Sarah Aherfi, Saadia Mokhtari, Catherine Dhiver, Isabelle Ravaux, Hervé Tissot-Dupont, Line Meddeb, Philippe Brouqui, Andreas Stein, Philippe Colson
No abstract text is available yet for this article.
January 10, 2017: Gut
https://www.readbyqxmd.com/read/28073888/selective-targeting-of-lysyl-oxidase-like-2-loxl2-suppresses-hepatic-fibrosis-progression-and-accelerates-its-reversal
#16
Naoki Ikenaga, Zhen-Wei Peng, Kahini A Vaid, Susan B Liu, Shuhei Yoshida, Deanna Y Sverdlov, Amanda Mikels-Vigdal, Victoria Smith, Detlef Schuppan, Yury V Popov
BACKGROUND/AIMS: We studied the role of lysyl oxidase-like 2 (LOXL2) in collagen crosslinking and hepatic progenitor cell (HPC) differentiation, and the therapeutic efficacy of a LOXL2-blocking monoclonal antibody on liver fibrosis progression/reversal in mice. METHODS: Anti-LOXL2 antibody, control antilysyl oxidase antibody or placebo was administered during thioacetamide (TAA)-induced fibrosis progression or during recovery. Therapeutic efficacy in biliary fibrosis was tested in BALB/c...
January 10, 2017: Gut
https://www.readbyqxmd.com/read/28069831/routine-assessment-of-the-gut-microbiome-to-promote-preclinical-research-reproducibility-and-transparency
#17
LETTER
Hannah R Wardill, Joanne M Bowen, Ysabella Za Van Sebille, Rachel J Gibson
No abstract text is available yet for this article.
January 9, 2017: Gut
https://www.readbyqxmd.com/read/28069830/meat-intake-and-risk-of-diverticulitis-among-men
#18
Yin Cao, Lisa L Strate, Brieze R Keeley, Idy Tam, Kana Wu, Edward L Giovannucci, Andrew T Chan
OBJECTIVE: Diverticulitis is a common disease with a substantial clinical and economic burden. Besides dietary fibre, the role of other foods in the prevention of diverticulitis is underexplored. DESIGN: We prospectively examined the association between consumption of meat (total red meat, red unprocessed meat, red processed meat, poultry and fish) with risk of incident diverticulitis among 46 461 men enrolled in the Health Professionals Follow-Up Study (1986-2012)...
January 9, 2017: Gut
https://www.readbyqxmd.com/read/28062523/water-activity-does-not-shape-the-microbiota-in-the-human-colon
#19
LETTER
Doris Vandeputte, Gwen Falony, Kevin D'hoe, Sara Vieira-Silva, Jeroen Raes
No abstract text is available yet for this article.
January 6, 2017: Gut
https://www.readbyqxmd.com/read/28057692/cdk4-6-inhibition-and-sorafenib-a-m%C3%A3-nage-%C3%A3-deux-in-hcc-therapy
#20
Diego Calvisi, Robert Eferl
No abstract text is available yet for this article.
January 5, 2017: Gut
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