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https://www.readbyqxmd.com/read/29785966/novel-prep-less-x-ray-imaging-capsule-for-colon-cancer-screening-a-feasibility-study
#1
Nathan Gluck, Elizabeth E Half, Vered Bieber, Doron Schwartz, Yulia Ron, Ian Gralnek, Amir Klein, Jesse Lachter, Moshe Shoni Levy, Menachem Moshkowitz, Nadir Arber
No abstract text is available yet for this article.
May 21, 2018: Gut
https://www.readbyqxmd.com/read/29785965/inflammatory-bowel-disease-increases-the-risk-of-parkinson-s-disease-a-danish-nationwide-cohort-study-1977-2014
#2
Marie Villumsen, Susana Aznar, Bente Pakkenberg, Tine Jess, Tomasz Brudek
OBJECTIVE: Intestinal inflammation has been suggested to play a role in development of Parkinson's disease (PD) and multiple system atrophy (MSA). To test the hypothesis that IBD is associated with risk of PD and MSA, we performed a nationwide population-based cohort study. DESIGN: The cohort consisted of all individuals diagnosed with IBD in Denmark during 1977-2014 (n=76 477) and non-IBD individuals from the general population, who were comparable in terms of gender, age and vital status (n=7 548 259)...
May 21, 2018: Gut
https://www.readbyqxmd.com/read/29778995/wide-field-endoscopic-mucosal-resection-versus-endoscopic-submucosal-dissection-for-laterally-spreading-colorectal-lesions-a-cost-effectiveness-analysis
#3
Farzan F Bahin, Steven J Heitman, Michael J Bourke
No abstract text is available yet for this article.
May 19, 2018: Gut
https://www.readbyqxmd.com/read/29777042/rates-of-infection-after-colonoscopy-and-osophagogastroduodenoscopy-in-ambulatory-surgery-centres-in-the-usa
#4
Peiqi Wang, Tim Xu, Saowanee Ngamruengphong, Martin A Makary, Anthony Kalloo, Susan Hutfless
OBJECTIVE: Over 15 million colonoscopies and 7 million osophagogastroduodenoscopies (OGDs) are performed annually in the USA. We aimed to estimate the rates of infections after colonoscopy and OGD performed in ambulatory surgery centres (ASCs). DESIGN: We identified colonoscopy and OGD procedures performed at ASCs in 2014 all-payer claims data from six states in the USA. Screening mammography, prostate cancer screening, bronchoscopy and cystoscopy procedures were comparators...
May 18, 2018: Gut
https://www.readbyqxmd.com/read/29777041/evolving-role-of-diet-in-the-pathogenesis-and-treatment-of-inflammatory-bowel-diseases
#5
REVIEW
Arie Levine, Rotem Sigall Boneh, Eytan Wine
Recent advances in basic and clinical science over the last 3 years have dramatically altered our appreciation of the role of diet in inflammatory bowel diseases (IBD). The marked increase in incidence of these diseases along with the important role of non-genetic susceptibility among patients with IBD has highlighted that these diseases have a strong environmental component. Progress in the field of microbiome and IBD has demonstrated that microbiome appears to play an important role in pathogenesis, and that diet may in turn impact the composition and functionality of the microbiome...
May 18, 2018: Gut
https://www.readbyqxmd.com/read/29760169/dysbiosis-of-maternal-and-neonatal-microbiota-associated-with-gestational-diabetes-mellitus
#6
Jinfeng Wang, Jiayong Zheng, Wenyu Shi, Nan Du, Xiaomin Xu, Yanming Zhang, Peifeng Ji, Fengyi Zhang, Zhen Jia, Yeping Wang, Zhi Zheng, Hongping Zhang, Fangqing Zhao
OBJECTIVE: The initial colonisation of the human microbiota and the impact of maternal health on neonatal microbiota at birth remain largely unknown. The aim of our study is to investigate the possible dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus (GDM) and to estimate the potential risks of the microbial shift to neonates. DESIGN: Pregnant women and neonates suffering from GDM were enrolled and 581 maternal (oral, intestinal and vaginal) and 248 neonatal (oral, pharyngeal, meconium and amniotic fluid) samples were collected...
May 14, 2018: Gut
https://www.readbyqxmd.com/read/29730604/elective-endoscopic-clipping-for-the-treatment-of-symptomatic-diverticular-disease-a-potential-for-cure
#7
Amyn Haji, Aris Plastiras, Monica Ortenzi, Shraddha Gulati, Andrew Emmanuel, Bu'Hussain Hayee
No abstract text is available yet for this article.
May 5, 2018: Gut
https://www.readbyqxmd.com/read/29730603/vedolizumab-is-associated-with-changes-in-innate-rather-than-adaptive-immunity-in-patients-with-inflammatory-bowel-disease
#8
Sebastian Zeissig, Elisa Rosati, C Marie Dowds, Konrad Aden, Johannes Bethge, Berenice Schulte, Wei Hung Pan, Neha Mishra, Maaz Zuhayra, Marlies Marx, Maren Paulsen, Anne Strigli, Claudio Conrad, Dörthe Schuldt, Anupam Sinha, Henriette Ebsen, Sabin-Christin Kornell, Susanna Nikolaus, Alexander Arlt, Dieter Kabelitz, Mark Ellrichmann, Ulf Lützen, Philip C Rosenstiel, Andre Franke, Stefan Schreiber
OBJECTIVE: Vedolizumab, a monoclonal antibody directed against the integrin heterodimer α4β7, is approved for the treatment of Crohn's disease and ulcerative colitis. The efficacy of vedolizumab has been suggested to result from inhibition of intestinal T cell trafficking although human data to support this conclusion are scarce. We therefore performed a comprehensive analysis of vedolizumab-induced alterations in mucosal and systemic immunity in patients with inflammatory bowel disease (IBD), using anti-inflammatory therapy with the TNFα antibody infliximab as control...
May 5, 2018: Gut
https://www.readbyqxmd.com/read/29730602/deep-learning-radiomics-of-shear-wave-elastography-significantly-improved-diagnostic-performance-for-assessing-liver-fibrosis-in-chronic-hepatitis-b-a-prospective-multicentre-study
#9
Kun Wang, Xue Lu, Hui Zhou, Yongyan Gao, Jian Zheng, Minghui Tong, Changjun Wu, Changzhu Liu, Liping Huang, Tian'an Jiang, Fankun Meng, Yongping Lu, Hong Ai, Xiao-Yan Xie, Li-Ping Yin, Ping Liang, Jie Tian, Rongqin Zheng
OBJECTIVE: We aimed to evaluate the performance of the newly developed deep learning Radiomics of elastography (DLRE) for assessing liver fibrosis stages. DLRE adopts the radiomic strategy for quantitative analysis of the heterogeneity in two-dimensional shear wave elastography (2D-SWE) images. DESIGN: A prospective multicentre study was conducted to assess its accuracy in patients with chronic hepatitis B, in comparison with 2D-SWE, aspartate transaminase-to-platelet ratio index and fibrosis index based on four factors, by using liver biopsy as the reference standard...
May 5, 2018: Gut
https://www.readbyqxmd.com/read/29730601/early-application-of-haemostatic-powder-added-to-standard-management-for-oesophagogastric-variceal-bleeding-a-randomised-trial
#10
Mostafa Ibrahim, Ahmed El-Mikkawy, Mohamed Abdel Hamid, Haitham Abdalla, Arnaud Lemmers, Ibrahim Mostafa, Jacques Devière
BACKGROUND: Acute variceal bleeding (AVB) requires early therapeutic management by experienced endoscopists that often poses logistical challenges for hospitals. We assessed a different management concept with early application of haemostatic powder-which does not require high endoscopic expertise-added to conventional management in a randomised trial. METHODS: Cirrhotic patients with AVB received standard medical therapy and were randomised to either immediate endoscopy with haemostatic powder application within 2 hours of admission, followed by early elective endoscopy on the next day, that is, within 12-24 hours of admission for definitive treatment (study group) or to early elective endoscopy only (control group)...
May 5, 2018: Gut
https://www.readbyqxmd.com/read/29730600/efficacy-of-pharmacological-therapies-for-the-treatment-of-opioid-induced-constipation-systematic-review-and-network-meta-analysis
#11
Pavit Luthra, Nicholas E Burr, Darren M Brenner, Alexander C Ford
OBJECTIVE: Opioids are increasingly prescribed in the West and have deleterious GI consequences. Pharmacological therapies to treat opioid-induced constipation (OIC) are available, but their relative efficacy is unclear. We performed a systematic review and network meta-analysis to address this deficit in current knowledge. DESIGN: We searched MEDLINE, EMBASE, EMBASE Classic and the Cochrane central register of controlled trials through to December 2017 to identify randomised controlled trials (RCTs) of pharmacological therapies in the treatment of adults with OIC...
May 5, 2018: Gut
https://www.readbyqxmd.com/read/29720409/a-simple-aged-score-for-risk-classification-of-primary-liver-cancer-development-and-validation-with-long-term-prospective-hbsag-positive-cohorts-in-qidong-china
#12
Chunsun Fan, Mengge Li, Yu Gan, Taoyang Chen, Yan Sun, Jianhua Lu, Jinbing Wang, Yan Jin, Jianquan Lu, Gengsun Qian, Jianren Gu, Jianguo Chen, Hong Tu
No abstract text is available yet for this article.
May 2, 2018: Gut
https://www.readbyqxmd.com/read/29720408/consecutive-negative-findings-on-colonoscopy-during-surveillance-predict-a-low-risk-of-advanced-neoplasia-in-patients-with-inflammatory-bowel-disease-with-long-standing-colitis-results-of-a-15-year-multicentre-multinational-cohort-study
#13
Joren R Ten Hove, Shailja C Shah, Seth R Shaffer, Charles N Bernstein, Daniel Castaneda, Carolina Palmela, Erik Mooiweer, Jordan Elman, Akash Kumar, Jason Glass, Jordan Axelrad, Thomas A Ullman, Jean-Frederic Colombel, Joana Torres, Adriaan A van Bodegraven, Frank Hoentjen, Jeroen M Jansen, Michiel E de Jong, Nofel Mahmmod, Andrea E van der Meulen-de Jong, Cyriel Y Ponsioen, Christine J van der Woude, Steven H Itzkowitz, Bas Oldenburg
OBJECTIVES: Surveillance colonoscopy is thought to prevent colorectal cancer (CRC) in patients with long-standing colonic IBD, but data regarding the frequency of surveillance and the findings thereof are lacking. Our aim was to determine whether consecutive negative surveillance colonoscopies adequately predict low neoplastic risk. DESIGN: A multicentre, multinational database of patients with long-standing IBD colitis without high-risk features and undergoing regular CRC surveillance was constructed...
May 2, 2018: Gut
https://www.readbyqxmd.com/read/29705728/understanding-the-gut-kidney-axis-in-nephrolithiasis-an-analysis-of-the-gut-microbiota-composition-and-functionality-of-stone-formers
#14
Andrea Ticinesi, Christian Milani, Angela Guerra, Franca Allegri, Fulvio Lauretani, Antonio Nouvenne, Leonardo Mancabelli, Gabriele Andrea Lugli, Francesca Turroni, Sabrina Duranti, Marta Mangifesta, Alice Viappiani, Chiara Ferrario, Rossella Dodi, Margherita Dall'Asta, Daniele Del Rio, Marco Ventura, Tiziana Meschi
OBJECTIVES: The involvement of the gut microbiota in the pathogenesis of calcium nephrolithiasis has been hypothesised since the discovery of the oxalate-degrading activity of Oxalobacter formigenes , but never comprehensively studied with metagenomics. The aim of this case-control study was to compare the faecal microbiota composition and functionality between recurrent idiopathic calcium stone formers (SFs) and controls. DESIGN: Faecal samples were collected from 52 SFs and 48 controls (mean age 48±11)...
April 28, 2018: Gut
https://www.readbyqxmd.com/read/29703791/human-gastric-cancer-modelling-using-organoids
#15
Therese Seidlitz, Sebastian R Merker, Alexander Rothe, Falk Zakrzewski, Cläre von Neubeck, Konrad Grützmann, Ulrich Sommer, Christine Schweitzer, Sebastian Schölch, Heike Uhlemann, Anne-Marlene Gaebler, Kristin Werner, Mechthild Krause, Gustavo B Baretton, Thilo Welsch, Bon-Kyoung Koo, Daniela E Aust, Barbara Klink, Jürgen Weitz, Daniel E Stange
OBJECTIVE: Gastric cancer is the second leading cause of cancer-related deaths and the fifth most common malignancy worldwide. In this study, human and mouse gastric cancer organoids were generated to model the disease and perform drug testing to delineate treatment strategies. DESIGN: Human gastric cancer organoid cultures were established, samples classified according to their molecular profile and their response to conventional chemotherapeutics tested. Targeted treatment was performed according to specific druggable mutations...
April 27, 2018: Gut
https://www.readbyqxmd.com/read/29703790/impact-of-sustained-virological-response-on-the-extrahepatic-manifestations-of-chronic-hepatitis-c-a-meta-analysis
#16
Patrice Cacoub, Anne Claire Desbois, Cloe Comarmond, David Saadoun
BACKGROUND AND AIMS: Extrahepatic manifestations of HCV are responsible for morbidity and mortality in many chronically infected patients. New, interferon-free antiviral treatment regimens, which present the opportunity to treat all HCV-infected patients, call for a better understanding of the benefits of treating non-cirrhotic chronically infected individuals. METHODS: A systematic review was conducted. Identified studies from targeted database searches on Embase and Medline were screened...
April 27, 2018: Gut
https://www.readbyqxmd.com/read/29700013/dynamic-human-immune-and-tumour-cells-cross-talk-in-pdx-humanised-mice-warrants-checkpoint-inhibitor-cancer-immunotherapies-assessment
#17
Nicolas Poirier, Bernard Vanhove
No abstract text is available yet for this article.
April 26, 2018: Gut
https://www.readbyqxmd.com/read/29695492/vdr-signaling-inhibits-cancer-associated-fibroblasts-release-of-exosomal-mir-10a-5p-and-limits-their-supportive-effects-on-pancreatic-cancer-cells
#18
Fanyang Kong, Lei Li, Guokun Wang, Xuan Deng, Zhaoshen Li, Xiangyu Kong
No abstract text is available yet for this article.
April 25, 2018: Gut
https://www.readbyqxmd.com/read/29691277/no-association-between-urbanisation-neighbourhood-deprivation-and-ibd-a-population-based-study-of-4-million-individuals
#19
Agnieszka Butwicka, Amir Sariaslan, Henrik Larsson, Jonas Halfvarson, Pär E Myrelid, Ola Olén, Louise Frisen, Paul Lichtenstein, Jonas F Ludvigsson
No abstract text is available yet for this article.
April 24, 2018: Gut
https://www.readbyqxmd.com/read/29691276/asia-pacific-working-group-consensus-on-non-variceal-upper-gastrointestinal-bleeding-an-update-2018
#20
Joseph Jy Sung, Philip Cy Chiu, Francis K L Chan, James Yw Lau, Khean-Lee Goh, Lawrence Hy Ho, Hwoon-Young Jung, Jose D Sollano, Takuji Gotoda, Nageshwar Reddy, Rajvinder Singh, Kentaro Sugano, Kai-Chun Wu, Chun-Yin Wu, David J Bjorkman, Dennis M Jensen, Ernst J Kuipers, Angel Lanas
Non-variceal upper gastrointestinal bleeding remains an important emergency condition, leading to significant morbidity and mortality. As endoscopic therapy is the 'gold standard' of management, treatment of these patients can be considered in three stages: pre-endoscopic treatment, endoscopic haemostasis and post-endoscopic management. Since publication of the Asia-Pacific consensus on non-variceal upper gastrointestinal bleeding (NVUGIB) 7 years ago, there have been significant advancements in the clinical management of patients in all three stages...
April 24, 2018: Gut
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