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https://www.readbyqxmd.com/read/29331947/response-to-prognosis-of-immune-tolerant-phase-chronic-hepatitis-b-by-chu-and-liaw
#1
Gi-Ae Kim, Young-Suk Lim
No abstract text is available yet for this article.
January 13, 2018: Gut
https://www.readbyqxmd.com/read/29331946/management-of-patients-on-antithrombotic-agents-undergoing-emergency-and-elective-endoscopy-joint-asian-pacific-association-of-gastroenterology-apage-and-asian-pacific-society-for-digestive-endoscopy-apsde-practice-guidelines
#2
Francis K L Chan, Khean-Lee Goh, Nageshwar Reddy, Kazuma Fujimoto, Khek Yu Ho, Seiji Hokimoto, Young-Hoon Jeong, Takanari Kitazono, Hong Sik Lee, Varocha Mahachai, Kelvin K F Tsoi, Ming-Shiang Wu, Bryan P Yan, Kentaro Sugano
This Guideline is a joint official statement of the Asian Pacific Association of Gastroenterology (APAGE) and the Asian Pacific Society for Digestive Endoscopy (APSDE). It was developed in response to the increasing use of antithrombotic agents (antiplatelet agents and anticoagulants) in patients undergoing gastrointestinal (GI) endoscopy in Asia. After reviewing current practice guidelines in Europe and the USA, the joint committee identified unmet needs, noticed inconsistencies, raised doubts about certain recommendations and recognised significant discrepancies in clinical practice between different regions...
January 13, 2018: Gut
https://www.readbyqxmd.com/read/29331945/risk-factors-for-gastric-cancer-is-it-time-to-discard-ppis
#3
Lucrezia Laterza, Franco Scaldaferri, Antonio Gasbarrini
No abstract text is available yet for this article.
January 13, 2018: Gut
https://www.readbyqxmd.com/read/29331944/liver-sampling-a-vital-window-into-hbv-pathogenesis-on-the-path-to-functional-cure
#4
REVIEW
Upkar S Gill, Laura J Pallett, Patrick T F Kennedy, Mala K Maini
In order to optimally refine the multiple emerging drug targets for hepatitis B virus (HBV), it is vital to evaluate virological and immunological changes at the site of infection. Traditionally liver biopsy has been the mainstay of HBV disease assessment, but with the emergence of non-invasive markers of liver fibrosis, there has been a move away from tissue sampling. Here we argue that liver biopsy remains an important tool, not only for the clinical assessment of HBV but also for research progress and evaluation of novel agents...
January 13, 2018: Gut
https://www.readbyqxmd.com/read/29331943/modern-management-of-perianal-fistulas-in-crohn-s-disease-future-directions
#5
REVIEW
Paulo Gustavo Kotze, Bo Shen, Amy Lightner, Takayuki Yamamoto, Antonino Spinelli, Subrata Ghosh, Remo Panaccione
Perianal fistulae in patients with Crohn's disease (CD) can be associated with significant morbidity resulting in negative impact on quality of life. The last two decades have seen significant advancements in the management of perianal fistulas in CD, which has evolved into a multidisciplinary approach that includes gastroenterologists, colorectal surgeons, endoscopists and radiologists. Despite the introduction of new medical therapies such as antitumour necrosis factor and novel models of care delivery, the best fistula healing rates reported with combined medical and surgical approaches are approximately 50%...
January 13, 2018: Gut
https://www.readbyqxmd.com/read/29331942/sucrase-isomaltase-15phe-ibs-risk-variant-in-relation-to-dietary-carbohydrates-and-faecal-microbiota-composition
#6
Louise Thingholm, Malte Rühlemann, Jun Wang, Matthias Hübenthal, Wolfgang Lieb, Matthias Laudes, Andre Franke, Mauro D'Amato
No abstract text is available yet for this article.
January 13, 2018: Gut
https://www.readbyqxmd.com/read/29331941/early-changes-in-the-pharmacokinetic-profile-of-vedolizumab-treated-patients-with-ibd-may-predict-response-after-dose-optimisation
#7
Célia Gouynou, Lieven Pouillon, Hélène Rousseau, Camille Zallot, Cédric Baumann, Laurent Peyrin-Biroulet
No abstract text is available yet for this article.
January 13, 2018: Gut
https://www.readbyqxmd.com/read/29330307/evidence-suggests-that-germline-rnf43-mutations-are-a-rare-cause-of-serrated-polyposis
#8
Isabel Quintana, Raquel Mejías-Luque, Mariona Terradas, Matilde Navarro, Virginia Piñol, Pilar Mur, Sami Belhadj, Elia Grau, Esther Darder, Ares Solanes, Joan Brunet, Gabriel Capellá, Markus Gerhard, Laura Valle
No abstract text is available yet for this article.
January 12, 2018: Gut
https://www.readbyqxmd.com/read/29321166/fetal-and-early-life-antibiotics-exposure-and-very-early-onset-inflammatory-bowel-disease-a-population-based-study
#9
Anne K Örtqvist, Cecilia Lundholm, Jonas Halfvarson, Jonas F Ludvigsson, Catarina Almqvist
OBJECTIVE: Earlier studies on antibiotics exposure and development of IBD (Crohn's disease (CD) and ulcerative colitis (UC)) may have been biased by familial factors and gastroenteritis. We aimed to estimate the association between antibiotics during pregnancy or infantile age and very early onset (VEO) IBD. DESIGN: In this cohort study of 827 239 children born in Sweden between 2006 and 2013, we examined the link between exposure to systemic antibiotics and VEO-IBD (diagnosis <6 years of age), using Cox proportional hazard regression models...
January 10, 2018: Gut
https://www.readbyqxmd.com/read/29306868/gastritis-staging-in-the-endoscopic-follow-up-for-the-secondary-prevention-of-gastric-cancer-a-5-year-prospective-study-of-1755-patients
#10
Massimo Rugge, Alberto Meggio, Cecilia Pravadelli, Mattia Barbareschi, Matteo Fassan, Maria Gentilini, Manuel Zorzi, Giovanni De Pretis, David Y Graham, Robert M Genta
OBJECTIVE: Operative link on gastritis assessment (OLGA) staging for gastritis ranks the risk for gastric cancer (GC) in progressive stages (0-IV). This prospective study aimed at quantifying the cancer risk associated with each gastritis stage. DESIGN: A cohort of 1755 consecutive patients with dyspepsia underwent initial (T-0) oesophagogastroduodenoscopy with mapped gastric biopsies, OLGA staging and assessment of Helicobacter pylori infection. Patients were followed for 55 months (median); patients with stages II III and IV underwent a second endoscopy/restaging (T-1), and those with stages 0 and I were followed clinically and through in-depth clinical and record checking...
January 6, 2018: Gut
https://www.readbyqxmd.com/read/29306867/efficacy-of-endoscopic-screening-for-esophageal-cancer-in-china-esecc-design-and-preliminary-results-of-a-population-based-randomised-controlled-trial
#11
Zhonghu He, Zhen Liu, Mengfei Liu, Chuanhai Guo, Ruiping Xu, Fenglei Li, Anxiang Liu, Haijun Yang, Lin Shen, Qi Wu, Liping Duan, Xiang Li, Chaoting Zhang, Yaqi Pan, Hong Cai, Yang Ke
OBJECTIVE: Description of the design and preliminary results of baseline recruitment and screening in the endoscopic screening for esophageal cancer in China (ESECC), the first randomised controlled trial (RCT) assessing efficacy and cost-effectiveness of endoscopic screening for esophageal squamous cell carcinoma (ESCC). DESIGN: ESECC trial is a cluster RCT, and 668 villages in rural Hua County, Henan Province, a high-incidence area of ESCC in China, were randomised into two arms at a ratio of 1:1...
January 6, 2018: Gut
https://www.readbyqxmd.com/read/29305432/a-case-of-sigmoid-volvulus
#12
Aikaterini Leventi, Thomas Frederick James Clifford, Amy Arnold, Charles H Knowles, Joanne E Martin
CLINICAL PRESENTATION: A 53-year-old man was admitted with a 2-week history of bowel obstruction on a background of gradually worsening dyspeptic symptoms associated with vomiting and weight loss. He was under regular gastroenterology review for Barrett's oesophagus and had a recent endoscopic diagnosis of megaduodenum (mainly D1 dilatation) confirmed by barium study (figure 1). He was also known to have bladder emptying problems and an enlarged bladder. His mother died at age 28 due to 'megacolon', and he has a monozygotic twin brother with Barrett's oesophagus...
January 5, 2018: Gut
https://www.readbyqxmd.com/read/29305431/case-of-nasogastric-tube-dysfunction
#13
Florian Rainer, Guenther Prenner, Lukas Peter Binder, Peter Fickert, Johannes Plank
CLINICAL PRESENTATION: An elderly female patient was admitted to intensive care for prolonged vasopressor therapy and mechanical ventilation after cardiac arrest and acute percutaneous coronary intervention. Antiplatelet, thyroid hormone replacement and statin therapies were administered through a 14-French nasogastric tube (Nestlé Health Science) and enteral feeding was initiated. Correct position of the nasogastric tube was confirmed radiologically. On the seventh day in the intensive care, our patient was seen to regurgitate soft crumbs into her mouth...
January 5, 2018: Gut
https://www.readbyqxmd.com/read/29298875/take-me-to-the-liver-adipose-tissue-macrophages-coordinate-hepatic-neutrophil-recruitment
#14
Gerard Pernes, Graeme I Lancaster, Andrew J Murphy
No abstract text is available yet for this article.
January 3, 2018: Gut
https://www.readbyqxmd.com/read/29298874/integrin-a6-loss-promotes-colitis-associated-colorectal-cancer-response-to-integrin-a6-variants-and-colorectal-cancer-by-beaulieu-jf
#15
Adèle De Arcangelis, Mathias Chamaillard, Patricia Simon-Assmann, Michel Labouesse
No abstract text is available yet for this article.
January 3, 2018: Gut
https://www.readbyqxmd.com/read/29298873/multicentre-prospective-evaluation-of-real-time-optical-diagnosis-of-t1-colorectal-cancer-in-large-non-pedunculated-colorectal-polyps-using-narrow-band-imaging-the-optical-study
#16
Yara Backes, Matthijs P Schwartz, Frank Ter Borg, Frank H J Wolfhagen, John N Groen, Wouter H de Vos Tot Nederveen Cappel, Jeroen van Bergeijk, Joost M J Geesing, Bernhard W M Spanier, Paul Didden, Frank P Vleggaar, Miangela M Lacle, Sjoerd G Elias, Leon M G Moons
OBJECTIVE: This study evaluated the preresection accuracy of optical diagnosis of T1 colorectal cancer (CRC) in large non-pedunculated colorectal polyps (LNPCPs). DESIGN: In this multicentre prospective study, endoscopists predicted the histology during colonoscopy in consecutive patients with LNPCPs using a standardised procedure for optical assessment. The presence of morphological features assessed with white light, and vascular and surface pattern with narrow-band imaging (NBI) were recorded, together with the optical diagnosis, the confidence level of prediction and the recommended treatment...
January 3, 2018: Gut
https://www.readbyqxmd.com/read/29298872/acute-sedation-associated-complications-in-gi-endoscopy-prosed-2-study-results-from-the-prospective-multicentre-electronic-registry-of-sedation-associated-complications
#17
Angelika Behrens, Anton Kreuzmayr, Hendrik Manner, Herbert Koop, Albrecht Lorenz, Claus Schaefer, Mathais Plauth, Jens-Uwe Jetschmann, Christian von Tirpitz, Marcus Ewald, Michael Sackmann, Wanja Renner, Martin Krüger, Dieter Schwab, Werner Hoffmann, Olaf Engelke, Oliver Pech, Frank Kullmann, Sonja Pampuch, Berthold Lenfers, Uwe Weickert, Dieter Schilling, Stephan Boehm, Susanne Beckebaum, Vito Cicinnati, Joachim F Erckenbrecht, Franz Ludwig Dumoulin, Claus Benz, Thomas Rabenstein, Georg Haltern, Martin Balsliemke, Christian de Mas, Gerhard Kleber, Christian Pehl, Christoph Vogt, Ralf Kiesslich, Wolfgang Fischbach, Irmtraut Koop, Jens Kuehne, Matthias Breidert, Nils Lennart Sass, Andrea May, Christian Friedrich, Ronni Veitt, Rainer Porschen, Mark Ellrichmann, Alexander Arlt, Wolfgang Schmitt, Markus Dollhopf, Werner Schmidbaur, Axel Dignass, Volker Schmitz, J Labenz, Gernot Kaiser, Alexander Krannich, Nico Barteska, Christian Ell
OBJECTIVES: Sedation has been established for GI endoscopic procedures in most countries, but it is also associated with an added risk of complications. Reported complication rates are variable due to different study methodologies and often limited sample size. DESIGNS: Acute sedation-associated complications were prospectively recorded in an electronic endoscopy documentation in 39 study centres between December 2011 and August 2014 (median inclusion period 24 months)...
January 3, 2018: Gut
https://www.readbyqxmd.com/read/29298871/role-of-thiopurines-as-disease-modifying-agents-in-crohn-s-disease
#18
Jonathan Blackwell, Sonia Saxena, Richard C Pollok
No abstract text is available yet for this article.
January 3, 2018: Gut
https://www.readbyqxmd.com/read/29298870/proton-pump-inhibitors-and-increased-gastric-cancer-risk-time-related-biases
#19
Samy Suissa, Alain Suissa
No abstract text is available yet for this article.
January 3, 2018: Gut
https://www.readbyqxmd.com/read/29275358/wild-type-kirsten-rat-sarcoma-is-a-novel-microrna-622-regulated-therapeutic-target-for-hepatocellular-carcinoma-and-contributes-to-sorafenib-resistance
#20
Peter Dietrich, Andreas Koch, Valerie Fritz, Arndt Hartmann, Anja Katrin Bosserhoff, Claus Hellerbrand
OBJECTIVE: Sorafenib is the only effective therapy for advanced hepatocellular carcinoma (HCC). Combinatory approaches targeting mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK)- and phosphatidylinositol-4,5-bisphosphate-3-kinase (PI3K)/protein-kinase B(AKT) signalling yield major therapeutic improvements. RAS proteins regulate both RAF/MAPK and PI3K/AKT signalling. However, the most important RAS isoform in carcinogenesis, Kirsten rat sarcoma (KRAS), remains unexplored in HCC...
December 23, 2017: Gut
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