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https://www.readbyqxmd.com/read/30012725/occult-blood-in-faeces-a-window-into-health-beyond-the-colorectum
#1
Uri Ladabaum
No abstract text is available yet for this article.
July 16, 2018: Gut
https://www.readbyqxmd.com/read/30012724/occult-blood-in-faeces-is-associated-with-all-cause-and-non-colorectal-cancer-mortality
#2
Gillian Libby, Callum G Fraser, Frank A Carey, David H Brewster, Robert J C Steele
OBJECTIVE: An association between detectable faecal haemoglobin (f-Hb) and both the risk of death from colorectal cancer (CRC) and all-cause mortality has been reported. We set out to confirm or refute this observation in a UK population and to explore the association between f-Hb, as indicated by a positive guaiac faecal occult blood test (gFOBT) result, and different causes of death. DESIGN: All individuals (134 192) who participated in gFOBT screening in Tayside, Scotland between 29/03/2000 and 29/03/2016 were studied by linking their test result (positive or negative) with mortality data from the National Records of Scotland database and following to 30/03/2016...
July 16, 2018: Gut
https://www.readbyqxmd.com/read/30007919/trem-1-the-ideal-predictive-biomarker-for-endoscopic-healing-in-anti-tnf-treated-crohn-s-disease-patients
#3
Bram Verstockt, Sare Verstockt, Helene Blevi, Isabelle Cleynen, Magali de Bruyn, Gert Van Assche, Séverine Vermeire, Marc Ferrante
No abstract text is available yet for this article.
July 14, 2018: Gut
https://www.readbyqxmd.com/read/30007918/gut-commensal-parabacteroides-goldsteinii-plays-a-predominant-role-in-the-anti-obesity-effects-of-polysaccharides-isolated-from-hirsutella-sinensis
#4
Tsung-Ru Wu, Chuan-Sheng Lin, Chih-Jung Chang, Tzu-Lung Lin, Jan Martel, Yun-Fei Ko, David M Ojcius, Chia-Chen Lu, John D Young, Hsin-Chih Lai
OBJECTIVE: The medicinal fungus Ophiocordyceps sinensis and its anamorph Hirsutella sinensis have a long history of use in traditional Chinese medicine for their immunomodulatory properties. Alterations of the gut microbiota have been described in obesity and type 2 diabetes. We examined the possibility that H. sinensis mycelium (HSM) and isolated fractions containing polysaccharides may prevent diet-induced obesity and type 2 diabetes by modulating the composition of the gut microbiota...
July 14, 2018: Gut
https://www.readbyqxmd.com/read/30006494/proton-pump-inhibitors-and-gastric-cancer-association-is-not-causation
#5
Paul Moayyedi, Sander J O Veldhuyzen van Zanten, Lawrence Hookey, David Armstrong, Nicola Jones, Grigorios I Leontiadis
No abstract text is available yet for this article.
July 13, 2018: Gut
https://www.readbyqxmd.com/read/29997133/prophylactic-angiographic-embolisation-in-high-risk-peptic-ulcer-bleeding-after-achieved-endoscopic-control-maximising-outcomes
#6
Romaric Loffroy, Marc Bardou
No abstract text is available yet for this article.
July 11, 2018: Gut
https://www.readbyqxmd.com/read/29991642/severe-obesity-and-gut-microbiota-does-bariatric-surgery-really-reset-the-system
#7
Patrice D Cani
No abstract text is available yet for this article.
July 10, 2018: Gut
https://www.readbyqxmd.com/read/29991641/evolutionary-history-of-human-colitis-associated-colorectal-cancer
#8
Ann-Marie Baker, William Cross, Kit Curtius, Ibrahim Al Bakir, Chang-Ho Ryan Choi, Hayley Louise Davis, Daniel Temko, Sujata Biswas, Pierre Martinez, Marc J Williams, James O Lindsay, Roger Feakins, Roser Vega, Stephen J Hayes, Ian P M Tomlinson, Stuart A C McDonald, Morgan Moorghen, Andrew Silver, James E East, Nicholas A Wright, Lai Mun Wang, Manuel Rodriguez-Justo, Marnix Jansen, Ailsa L Hart, Simon J Leedham, Trevor A Graham
OBJECTIVE: IBD confers an increased lifetime risk of developing colorectal cancer (CRC), and colitis-associated CRC (CA-CRC) is molecularly distinct from sporadic CRC (S-CRC). Here we have dissected the evolutionary history of CA-CRC using multiregion sequencing. DESIGN: Exome sequencing was performed on fresh-frozen multiple regions of carcinoma, adjacent non-cancerous mucosa and blood from 12 patients with CA-CRC (n=55 exomes), and key variants were validated with orthogonal methods...
July 10, 2018: Gut
https://www.readbyqxmd.com/read/29982192/proton-pump-inhibitors-and-suppression-of-duodenal-eosinophilia-in-functional-dyspepsia
#9
Michael D E Potter, Nicola K Wood, Marjorie M Walker, Michael P Jones, Nicholas J Talley
No abstract text is available yet for this article.
July 7, 2018: Gut
https://www.readbyqxmd.com/read/29980607/faecal-microbiota-transplantation-alters-gut-microbiota-in-patients-with-irritable-bowel-syndrome-results-from-a-randomised-double-blind-placebo-controlled-study
#10
Sofie Ingdam Halkjær, Alice Højer Christensen, Bobby Zhao Sheng Lo, Patrick Denis Browne, Stig Günther, Lars Hestbjerg Hansen, Andreas Munk Petersen
OBJECTIVE: IBS is associated with an intestinal dysbiosis and faecal microbiota transplantation (FMT) has been hypothesised to have a positive effect in patients with IBS. We performed a randomised, double-blind placebo-controlled trial to investigate if FMT resulted in an altered gut microbiota and improvement in clinical outcome in patients with IBS. DESIGN: We performed this study in 52 adult patients with moderate-to-severe IBS. At the screening visit, clinical history and symptoms were assessed and faecal samples were collected...
July 6, 2018: Gut
https://www.readbyqxmd.com/read/29980606/assessing-the-efficacy-of-peripherally-acting-%C3%A2%C2%B5-opioid-receptor-antagonists-pamoras-in-the-treatment-of-opioid-induced-constipation-authors-reply
#11
Nicholas E Burr, Alexander C Ford
No abstract text is available yet for this article.
July 6, 2018: Gut
https://www.readbyqxmd.com/read/29970455/multidimensional-analyses-reveal-distinct-immune-microenvironment-in-hepatitis-b-virus-related-hepatocellular-carcinoma
#12
Chun Jye Lim, Yun Hua Lee, Lu Pan, Liyun Lai, Camillus Chua, Martin Wasser, Tony Kiat Hon Lim, Joe Yeong, Han Chong Toh, Ser Yee Lee, Chung Yip Chan, Brian Kp Goh, Alexander Chung, Mathias Heikenwälder, Irene Ol Ng, Pierce Chow, Salvatore Albani, Valerie Chew
BACKGROUND AND AIMS: Chronic inflammation induced by chronic hepatitis B virus (HBV) infection increases the risk of hepatocellular carcinoma (HCC). However, little is known about the immune landscape of HBV-related HCC and its influence on the design of effective cancer immunotherapeutics. METHODS: We interrogated the immune microenvironments of HBV-related HCC and non-viral-related HCC using immunohistochemistry and ytometry by time-of-flight (CyTOF). On identifying unique immune subsets enriched in HBV-related HCC, we further interrogated their phenotypes and functions using next-generation sequencing (NGS) and in vitro T-cell proliferation assays...
July 3, 2018: Gut
https://www.readbyqxmd.com/read/29960981/geographic-variation-in-molecular-subtype-for-gastric-adenocarcinoma
#13
Ping Liao, Feifei Jia, Jamie K Teer, Todd C Knepper, Hong-Hao Zhou, Yi-Jing He, Howard L McLeod
No abstract text is available yet for this article.
June 29, 2018: Gut
https://www.readbyqxmd.com/read/29959169/what-is-required-from-hcv-point-of-care-tests-to-reduce-the-burden-of-hepatitis-c-infection-development-and-clinical-validation-of-the-genedrive-point-of-care-test-for-qualitative-detection-of-hepatitis-c-virus
#14
https://www.readbyqxmd.com/read/29959168/multiple-hbv-transfusion-transmissions-from-undetected-occult-infections-revising-the-minimal-infectious-dose
#15
Daniel Candotti, Sonny Michael Assennato, Syria Laperche, Jean-Pierre Allain, Snezna Levicnik-Stezinar
OBJECTIVE: HBV infection by blood components is currently prevented in most developed countries by combining sensitive HBV surface antigen (HBsAg) assays, nucleic acid testing (NAT) and in a few of them antibodies against the HBV core antigen (anti-HBc) screening. HBV transmissions by blood components from three repeat donors tested negative for HBsAg and HBV DNA with a highly sensitive screening test (limit of detection (LOD): 3.4 IU/mL) were investigated. DESIGN: 30 of the 47 recipients of components produced from these three donors were examined...
June 29, 2018: Gut
https://www.readbyqxmd.com/read/29954840/genomic-erbb2-erbb3-mutations-promote-pd-l1-mediated-immune-escape-in-gallbladder-cancer-a-whole-exome-sequencing-analysis
#16
Maolan Li, Fatao Liu, Fei Zhang, Weiping Zhou, Xiaoqing Jiang, Yuan Yang, Kai Qu, Yueqi Wang, Qiang Ma, Ting Wang, Lu Bai, Zheng Wang, Xiaoling Song, Yidi Zhu, Ruiyan Yuan, Yuan Gao, Yongchen Liu, Yunpeng Jin, Huaifeng Li, Shanshan Xiang, Yuanyuan Ye, Yijian Zhang, Lin Jiang, Yunping Hu, Yajuan Hao, Wei Lu, Shili Chen, Jun Gu, Jian Zhou, Wei Gong, Yong Zhang, Xuefeng Wang, Xiyong Liu, Chang Liu, Houbao Liu, Yun Liu, Yingbin Liu
OBJECTIVES: Patients with gallbladder carcinoma (GBC) lack effective treatment methods largely due to the inadequacy of both molecular characterisation and potential therapeutic targets. We previously uncovered a spectrum of genomic alterations and identified recurrent mutations in the ErbB pathway in GBC. Here, we aimed to study recurrent mutations of genes and pathways in a larger cohort of patients with GBC and investigate the potential mechanisms and clinical significance of these mutations...
June 28, 2018: Gut
https://www.readbyqxmd.com/read/29950344/impact-of-characteristics-of-organ-failure-and-infected-necrosis-on-mortality-in-necrotising-pancreatitis
#17
Nicolien J Schepers, Olaf J Bakker, Marc G Besselink, Usama Ahmed Ali, Thomas L Bollen, Hein G Gooszen, Hjalmar C van Santvoort, Marco J Bruno
OBJECTIVE: In patients with pancreatitis, early persisting organ failure is believed to be the most important cause of mortality. This study investigates the relation between the timing (onset and duration) of organ failure and mortality and its association with infected pancreatic necrosis in patients with necrotising pancreatitis. DESIGN: We performed a post hoc analysis of a prospective database of 639 patients with necrotising pancreatitis from 21 hospitals...
June 27, 2018: Gut
https://www.readbyqxmd.com/read/29934439/patients-with-colorectal-cancer-have-identical-strains-of-fusobacterium-nucleatum-in-their-colorectal-cancer-and-oral-cavity
#18
Yasuhiko Komiya, Yumi Shimomura, Takuma Higurashi, Yutaka Sugi, Jun Arimoto, Shotaro Umezawa, Shiori Uchiyama, Mitsuharu Matsumoto, Atsushi Nakajima
No abstract text is available yet for this article.
June 22, 2018: Gut
https://www.readbyqxmd.com/read/29934438/-lactobacillus-rhamnosus-gg-protects-the-intestinal-epithelium-from-radiation-injury-through-release-of-lipoteichoic-acid-macrophage-activation-and-the-migration-of-mesenchymal-stem-cells
#19
Terrence E Riehl, David Alvarado, Xueping Ee, Aaron Zuckerman, Lynn Foster, Vaishali Kapoor, Dinesh Thotala, Matthew A Ciorba, William F Stenson
OBJECTIVE: Lactobacillus rhamnosus GG (LGG), a probiotic, given by gavage is radioprotective of the mouse intestine. LGG-induced radioprotection is toll-like receptor 2 (TLR2) and cyclooxygenase-2 (COX-2)-dependent and is associated with the migration of COX-2+mesenchymal stem cells (MSCs) from the lamina propria of the villus to the lamina propria near the crypt epithelial stem cells. Our goals were to define the mechanism of LGG radioprotection including identification of the TLR2 agonist, and the mechanism of the MSC migration and to determine the safety and efficacy of this approach in models relevant to clinical radiation therapy...
June 22, 2018: Gut
https://www.readbyqxmd.com/read/29934437/human-gut-microbiome-hopes-threats-and-promises
#20
REVIEW
Patrice D Cani
The microbiome has received increasing attention over the last 15 years. Although gut microbes have been explored for several decades, investigations of the role of microorganisms that reside in the human gut has attracted much attention beyond classical infectious diseases. For example, numerous studies have reported changes in the gut microbiota during not only obesity, diabetes, and liver diseases but also cancer and even neurodegenerative diseases. The human gut microbiota is viewed as a potential source of novel therapeutics...
June 22, 2018: Gut
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