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Gut

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https://www.readbyqxmd.com/read/27899418/reply-to-letter-to-the-editor-of-gut
#1
LETTER
Ji Young Bang, Shyam Varadarajulu
No abstract text is available yet for this article.
November 29, 2016: Gut
https://www.readbyqxmd.com/read/27888235/rare-cause-of-abdominal-pain-and-fever-in-a-pregnant-woman
#2
Sophie Hillaire, Jean-Emmanuel Kahn, Olivier Picone, Dominique Cazals-Hatem
No abstract text is available yet for this article.
November 25, 2016: Gut
https://www.readbyqxmd.com/read/27884921/reply-more-viral-mutants-less-hbsag-clearance-one-size-may-not-fit-all
#3
LETTER
Alex Thompson, Stephen Locarnini, Peter Revill
No abstract text is available yet for this article.
November 24, 2016: Gut
https://www.readbyqxmd.com/read/27884920/systematic-review-of-bariatric-surgery-liver-biopsies-clarifies-the-natural-history-of-liver-disease-in-patients-with-severe-obesity
#4
Pierre Bedossa, Joan Tordjman, Judith Aron-Wisnewsky, Christine Poitou, Jean-Michel Oppert, Adriana Torcivia, Jean-Luc Bouillot, Valerie Paradis, Vlad Ratziu, Karine Clément
OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is a frequent complication of morbid obesity, but its severity varies greatly and thus there is a strong need to better define its natural history in these patients. DESIGN: Liver biopsies were systematically performed in 798 consecutive patients with severe obesity undergoing bariatric surgery. Histology was compared with clinical, biological, anthropometrical and body composition characteristics. RESULTS: Patients with presumably normal liver (n=179, 22%) were significantly younger at bariatric surgery than patients with NAFLD (37...
November 24, 2016: Gut
https://www.readbyqxmd.com/read/27884919/percutaneous-cooled-probe-microwave-versus-radiofrequency-ablation-in-early-stage-hepatocellular-carcinoma-a-phase-iii-randomised-controlled-trial
#5
LETTER
Jie Yu, Xiao-Ling Yu, Zhi-Yu Han, Zhi-Gang Cheng, Fang-Yi Liu, Hong-Yan Zhai, Meng-Juan Mu, Yan-Mei Liu, Ping Liang
No abstract text is available yet for this article.
November 24, 2016: Gut
https://www.readbyqxmd.com/read/27872184/functional-variants-in-the-sucrase-isomaltase-gene-associate-with-increased-risk-of-irritable-bowel-syndrome
#6
Maria Henström, Lena Diekmann, Ferdinando Bonfiglio, Fatemeh Hadizadeh, Eva-Maria Kuech, Maren von Köckritz-Blickwede, Louise B Thingholm, Tenghao Zheng, Ghazaleh Assadi, Claudia Dierks, Martin Heine, Ute Philipp, Ottmar Distl, Mary E Money, Meriem Belheouane, Femke-Anouska Heinsen, Joseph Rafter, Gerardo Nardone, Rosario Cuomo, Paolo Usai-Satta, Francesca Galeazzi, Matteo Neri, Susanna Walter, Magnus Simrén, Pontus Karling, Bodil Ohlsson, Peter T Schmidt, Greger Lindberg, Aldona Dlugosz, Lars Agreus, Anna Andreasson, Emeran Mayer, John F Baines, Lars Engstrand, Piero Portincasa, Massimo Bellini, Vincenzo Stanghellini, Giovanni Barbara, Lin Chang, Michael Camilleri, Andre Franke, Hassan Y Naim, Mauro D'Amato
OBJECTIVE: IBS is a common gut disorder of uncertain pathogenesis. Among other factors, genetics and certain foods are proposed to contribute. Congenital sucrase-isomaltase deficiency (CSID) is a rare genetic form of disaccharide malabsorption characterised by diarrhoea, abdominal pain and bloating, which are features common to IBS. We tested sucrase-isomaltase (SI) gene variants for their potential relevance in IBS. DESIGN: We sequenced SI exons in seven familial cases, and screened four CSID mutations (p...
November 21, 2016: Gut
https://www.readbyqxmd.com/read/27856614/next-generation-of-small-molecules-in-inflammatory-bowel-disease
#7
Pablo Olivera, Silvio Danese, Laurent Peyrin-Biroulet
No abstract text is available yet for this article.
November 17, 2016: Gut
https://www.readbyqxmd.com/read/27902444/oncolytic-reovirus-as-a-combined-antiviral-and-anti-tumour-agent-for-the-treatment-of-liver-cancer
#8
Adel Samson, Matthew J Bentham, Karen Scott, Gerard Nuovo, Abigail Bloy, Elizabeth Appleton, Robert A Adair, Rajiv Dave, Adam Peckham-Cooper, Giles Toogood, Seishi Nagamori, Matthew Coffey, Richard Vile, Kevin Harrington, Peter Selby, Fiona Errington-Mais, Alan Melcher, Stephen Griffin
OBJECTIVE: Oncolytic viruses (OVs) represent promising, proinflammatory cancer treatments. Here, we explored whether OV-induced innate immune responses could simultaneously inhibit HCV while suppressing hepatocellular carcinoma (HCC). Furthermore, we extended this exemplar to other models of virus-associated cancer. DESIGN AND RESULTS: Clinical grade oncolytic orthoreovirus (Reo) elicited innate immune activation within primary human liver tissue in the absence of cytotoxicity and independently of viral genome replication...
November 15, 2016: Gut
https://www.readbyqxmd.com/read/27852795/modifiable-lifestyle-factors-associated-with-risk-of-sessile-serrated-polyps-conventional-adenomas-and-hyperplastic-polyps
#9
James R Davenport, Timothy Su, Zhiguo Zhao, Helen G Coleman, Walter E Smalley, Reid M Ness, Wei Zheng, Martha J Shrubsole
OBJECTIVE: To identify modifiable factors associated with sessile serrated polyps (SSPs) and compare the association of these factors with conventional adenomas (ADs) and hyperplastic polyps (HPs). DESIGN: We used data from the Tennessee Colorectal Polyp Study, a colonoscopy-based case-control study. Included were 214 SSP cases, 1779 AD cases, 560 HP cases and 3851 polyp-free controls. RESULTS: Cigarette smoking was associated with increased risk for all polyps and was stronger for SSPs than for ADs (OR 1...
November 15, 2016: Gut
https://www.readbyqxmd.com/read/27852794/prevalence-of-serrated-polyposis-syndrome-in-an-fit-based-colorectal-cancer-screening-cohort-in-italy
#10
LETTER
Dora Colussi, Rocco Maurizio Zagari, Beatrice Morini, Margherita Fabbri, Amedeo Montale, Cesare Hassan, Carlo Senore, Franco Bazzoli, Luigi Ricciardiello
No abstract text is available yet for this article.
November 15, 2016: Gut
https://www.readbyqxmd.com/read/27849562/palbociclib-pd-0332991-a-selective-cdk4-6-inhibitor-restricts-tumour-growth-in-preclinical-models-of-hepatocellular-carcinoma
#11
Julien Bollard, Verónica Miguela, Marina Ruiz de Galarreta, Anu Venkatesh, C Billie Bian, Mark P Roberto, Victoria Tovar, Daniela Sia, Pedro Molina-Sánchez, Christie B Nguyen, Shigeki Nakagawa, Josep M Llovet, Yujin Hoshida, Amaia Lujambio
OBJECTIVE: Advanced hepatocellular carcinoma (HCC) is a lethal malignancy with limited treatment options. Palbociclib, a well-tolerated and selective CDK4/6 inhibitor, has shown promising results in the treatment of retinoblastoma (RB1)-positive breast cancer. RB1 is rarely mutated in HCC, suggesting that palbociclib could potentially be used for HCC therapy. Here, we provide a comprehensive characterisation of the efficacy of palbociclib in multiple preclinical models of HCC. DESIGN: The effects of palbociclib on cell proliferation, cellular senescence and cell death were investigated in a panel of human liver cancer cell lines, in ex vivo human HCC samples, in a genetically engineered mouse model of liver cancer, and in human HCC xenografts in vivo...
November 14, 2016: Gut
https://www.readbyqxmd.com/read/27849561/train-the-trainer-education-and-colonoscopy-quality-indicators-where-to-now
#12
LETTER
Stuart K Roberts
No abstract text is available yet for this article.
November 14, 2016: Gut
https://www.readbyqxmd.com/read/27849560/blood-group-b-is-associated-with-azathioprine-induced-acute-pancreatitis-in-patients-with-ibd
#13
LETTER
Niels Teich, Bernd Bokemeyer, Wolfgang Mohl, Jens Walldorf, Tony Bruns, Carsten Schmidt, Andreas Stallmach
No abstract text is available yet for this article.
November 14, 2016: Gut
https://www.readbyqxmd.com/read/27849559/ethics-and-hepatitis-b-cure-research
#14
Jeremy Sugarman, Peter Revill, Fabien Zoulim, Yazdan Yazdanpanah, Harry L A Janssen, Seng Gee Lim, Sharon R Lewin
No abstract text is available yet for this article.
November 14, 2016: Gut
https://www.readbyqxmd.com/read/27849558/identification-of-a-fluorescent-small-molecule-enhancer-for-therapeutic-autophagy-in-colorectal-cancer-by-targeting-mitochondrial-protein-translocase-tim44
#15
Yinghui Huang, Jie Zhou, Shenglin Luo, Yang Wang, Jintao He, Peng Luo, Zelin Chen, Tao Liu, Xu Tan, Juanjuan Ou, Hongming Miao, Houjie Liang, Chunmeng Shi
OBJECTIVE: As the modulation of autophagic processes can be therapeutically beneficial to cancer treatment, the identification of novel autophagic enhancers is highly anticipated. However, current autophagy-inducing anticancer agents exert undesired side effects owing to their non-specific biodistribution in off-target tissues. This study aims to develop a multifunctional agent to integrate cancer targeting, imaging and therapy and to investigate its mechanism. DESIGN: A series of mitochondria-targeting near-infrared (NIR) fluorophores were synthesised, screened and identified for their autophagy-enhancing activity...
November 14, 2016: Gut
https://www.readbyqxmd.com/read/27821646/protein-and-glycomic-plasma-markers-for-early-detection-of-adenoma-and-colon-cancer
#16
Jung-Hyun Rho, Jon J Ladd, Christopher I Li, John D Potter, Yuzheng Zhang, David Shelley, David Shibata, Domenico Coppola, Hiroyuki Yamada, Hidenori Toyoda, Toshifumi Tada, Takashi Kumada, Dean E Brenner, Samir M Hanash, Paul D Lampe
OBJECTIVE: To discover and confirm blood-based colon cancer early-detection markers. DESIGN: We created a high-density antibody microarray to detect differences in protein levels in plasma from individuals diagnosed with colon cancer <3 years after blood was drawn (ie, prediagnostic) and cancer-free, matched controls. Potential markers were tested on plasma samples from people diagnosed with adenoma or cancer, compared with controls. Components of an optimal 5-marker panel were tested via immunoblotting using a third sample set, Luminex assay in a large fourth sample set and immunohistochemistry (IHC) on tissue microarrays...
November 7, 2016: Gut
https://www.readbyqxmd.com/read/27815288/lumen-apposing-metal-stents-for-pancreatic-fluid-collection-drainage-may-not-be-business-as-usual
#17
LETTER
John S Leeds, Manu K Nayar, Richard M Charnley, Kofi W Oppong
No abstract text is available yet for this article.
November 4, 2016: Gut
https://www.readbyqxmd.com/read/27811314/epigenetic-treatment-of-pancreatic-cancer-is-there-a-therapeutic-perspective-on-the-horizon
#18
REVIEW
Elisabeth Hessmann, Steven A Johnsen, Jens T Siveke, Volker Ellenrieder
Pancreatic ductal adenocarcinoma (PDAC) constitutes one of the most aggressive malignancies with a 5-year survival rate of <7%. Due to growing incidence, late diagnosis and insufficient treatment options, PDAC is predicted to soon become one of the leading causes of cancer-related death. Although intensified cytostatic combinations, particularly gemcitabine plus nab-paclitaxel and the folinic acid, fluorouracil, irinotecan, oxaliplatin (FOLFIRINOX) protocol, provide some improvement in efficacy and survival compared with gemcitabine alone, a breakthrough in the treatment of metastatic pancreatic cancer remains out of sight...
November 3, 2016: Gut
https://www.readbyqxmd.com/read/27811313/endoscopic-resection-of-high-risk-t1-colorectal-carcinoma-prior-to-surgical-resection-has-no-adverse-effect-on-long-term-outcomes
#19
A Overwater, K Kessels, S G Elias, Y Backes, B W M Spanier, T C J Seerden, H J M Pullens, W H de Vos Tot Nederveen Cappel, A van den Blink, G J A Offerhaus, J van Bergeijk, M Kerkhof, J M J Geesing, J N Groen, N van Lelyveld, F Ter Borg, F Wolfhagen, P D Siersema, M M Lacle, L M G Moons
OBJECTIVE: It is difficult to predict the presence of histological risk factors for lymph node metastasis (LNM) before endoscopic treatment of T1 colorectal cancer (CRC). Therefore, endoscopic therapy is propagated to obtain adequate histological staging. We examined whether secondary surgery following endoscopic resection of high-risk T1 CRC does not have a negative effect on patients' outcomes compared with primary surgery. DESIGN: Patients with T1 CRC with one or more histological risk factors for LNM (high risk) and treated with primary or secondary surgery between 2000 and 2014 in 13 hospitals were identified in the Netherlands Cancer Registry...
November 3, 2016: Gut
https://www.readbyqxmd.com/read/27811312/unravelling-the-multiple-roles-of-apolipoprotein-e-in-the-hepatitis-c-virus-life-cycle
#20
Philippe Roingeard, Julie Dreneau, Jean-Christophe Meunier
No abstract text is available yet for this article.
November 3, 2016: Gut
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