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European Journal of Clinical Pharmacology

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https://www.readbyqxmd.com/read/28435984/patterns-predictors-and-persistence-of-chronic-sedative-use-a-population-based-observational-study-of-older-adults-in-british-columbia-canada
#1
Steven G Morgan, Deirdre Weymann
BACKGROUND: Benzodiazepines and benzodiazepine-like sedatives (zopiclone, zolpidem and zaleplon) are commonly prescribed to treat anxiety and insomnia but are contraindicated for chronic use. We sought to study the persistence, over multiple years, of chronic use of benzodiazepines and benzodiazepine-like sedatives among community-dwelling adults in British Columbia, Canada. METHODS: This is a retrospective analysis of linked health data for adults aged 50 to 69 in 2004 who resided in British Columbia, Canada, between 2004 and 2013...
April 24, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28434021/correlation-between-proton-pump-inhibitors-and-risk-of-pyogenic-liver-abscess
#2
Hsien-Feng Lin, Kuan-Fu Liao, Ching-Mei Chang, Cheng-Li Lin, Shih-Wei Lai
BACKGROUND/OBJECTIVE: Little is known about the relationship between proton pump inhibitors use and pyogenic liver abscess. The objective of this study was to evaluate the correlation between proton pump inhibitors use and pyogenic liver abscess in Taiwan. METHODS: This was a population-based case-control study using the database of the Taiwan National Health Insurance Program since 2000 to 2011. Subjects aged 20 to 84 who experienced their first episode of pyogenic liver abscess were enrolled as the case group (n = 1372)...
April 22, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28417149/clincal-interpretation-of-the-anti-tuberculosis-drug-concentrations-in-diabetic-and-non-diabetic-tuberculosis-patients
#3
LETTER
Nilan T Jacob
No abstract text is available yet for this article.
April 17, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28409297/the-slco1a2-189_-188insa-polymorphism-reduces-clearance-of-rocuronium-in-patients-submitted-to-elective-surgeries
#4
A C C Costa, E B Coelho, V L Lanchote, B V Correia, J T Abumansur, G R Lauretti, N V de Moraes
PURPOSE: Rocuronium (ROC) is a neuromuscular blocker mainly eliminated by biliary excretion dependent on organic anion transporting polypeptide 1A2 (OATP1A2) hepatocellular uptake. However, the influence of SLCO1A2 (gene encoding OATP1A2) genetic polymorphism on ROC pharmacokinetics was never described before. The objective of this work was to evaluate the influence of genetic polymorphisms of SLCO1A2 on the pharmacokinetics of rocuronium (ROC). METHODS: Patients undergoing elective surgeries under general anesthesia using rocuronium as a neuromuscular blocker were genotyped for SLCO1A2 polymorphisms in the coding region (41A>G, 382A>T, 404A>T, 502C>T, 516A>C, 559G>A, 830C>A, and 833delA) and in the promoter region (-1105G>A, -1032G>A, -715T>C, -361G>A, and -189_-188insA)...
April 14, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28405697/potentially-inappropriate-medicines-in-elderly-hospitalised-patients-according-to-the-eu-7-pim-list-stopp-version-2-criteria-and-comprehensive-protocol
#5
Iva Mucalo, Maja Ortner Hadžiabdić, Andrea Brajković, Sonja Lukić, Patricia Marić, Ivana Marinović, Vesna Bačić-Vrca
PURPOSE: The aim of this study was to measure the prevalence of potentially inappropriate medications (PIMs) by using the EU(7)-PIM list, STOPP (Screening Tool of Older Persons' potentially inappropriate Prescriptions) version 2 criteria and the new comprehensive protocol. METHODS: This prospective study involved a sample of 276 consecutive elderly patients discharged from the university teaching hospital. Age, gender, diagnoses, medication history and medicines at discharge were recorded...
April 12, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28391409/pharmacist-participation-in-hospital-ward-teams-and-hospital-readmission-rates-among-people-with-dementia-a-randomized-controlled-trial
#6
Maria Gustafsson, Maria Sjölander, Bettina Pfister, Jeanette Jonsson, Jörn Schneede, Hugo Lövheim
PURPOSE: To assess whether comprehensive medication reviews conducted by clinical pharmacists as part of a healthcare team reduce drug-related hospital readmission rates among people with dementia or cognitive impairment. METHODS: This randomized controlled trial was carried out between January 9, 2012, and December 2, 2014. Patients aged ≥65 years with dementia or cognitive impairment admitted to three wards at two hospitals located in Northern Sweden were included...
April 8, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28391408/informativeness-of-patient-initial-reports-of-adverse-drug-reactions-can-it-be-improved-by-a-pharmacovigilance-centre
#7
F Kheloufi, A Default, F Rouby, D Laugier-Castellan, M Boyer, B Rodrigues, J Ponte-Astoul, M J Jean-Pastor, O Blin, J Micallef
PURPOSE: Little is known about the informativeness of initial patient reports before they are reviewed by a pharmacovigilance centre (PVC). We aim to describe the patterns of patient adverse drug reaction (ADR) reporting in France and estimate the contribution of a review by a PVC assessor on the informativeness of these reports. METHODS: A retrospective study was conducted on patient reports between July 2011 and July 2015. Informativeness of 16 key elements of information (including drug start and end date, duration of treatment, time to onset and duration of the ADR, outcome, medical history and concomitant medication) was assessed in initial reports before and after review by a pharmacovigilance assessor...
April 8, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28391407/influence-of-genetic-and-non-genetic-factors-on-phenytoin-induced-severe-cutaneous-adverse-drug-reactions
#8
Kittika Yampayon, Chonlaphat Sukasem, Chanin Limwongse, Yotin Chinvarun, Therdpong Tempark, Ticha Rerkpattanapipat, Pornpimol Kijsanayotin
PURPOSE: The purpose of this study was to investigate the association of genetic factors including variants in HLA-B and CYP2C genes and non-genetic factors with phenotype-specific phenytoin (PHT)-induced severe cutaneous adverse reactions (SCARs) in Thai patients. METHODS: Thirty-six PHT-induced SCAR cases (15 Stevens-Johnson syndrome (SJS) and 21 drug rash with eosinophilia and systemic symptoms (DRESS)/drug hypersensitivity syndrome (DHS)) and 100 PHT-tolerant controls were studied...
April 8, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28391406/association-between-cacna1c-gene-polymorphisms-and-ritodrine-induced-adverse-events-in-preterm-labor-patients
#9
Min Young Baek, Han Sung Hwang, Jin Young Park, Jee Eun Chung, Kyung Eun Lee, Gwan Yung Lee, Jin Won Seong, Jeong Yee, Young Ju Kim, Hye Sun Gwak
PURPOSE: As a tocolytic agent, ritodrine has been used in European and Asian countries but has lost popularity due to safety concerns. This study aimed to investigate the relationship between adverse drug events caused by ritodrine and the CACNA1C polymorphisms in preterm labor patients. METHODS: Data were collected from medical records including maternal age, gestational age, body mass index, dilation score, effacement score, modified Bishop score, maximum infusion rate, and adverse drug events...
April 8, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28389679/erratum-to-changes-in-utilisation-of-antiepileptic-drugs-in-epilepsy-and-non-epilepsy-disorders-a-pharmacoepidemiological-study-and-clinical-implications
#10
Arton Baftiu, Cecilie Johannessen Landmark, Ida Rudberg Rusten, Silje Andrea Feet, Svein I Johannessen, Pål G Larsson
No abstract text is available yet for this article.
April 7, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28386684/extrapyramidal-symptoms-after-exposure-to-calcium-channel-blocker-flunarizine-or-cinnarizine
#11
Kai-Ming Jhang, Jing-Yang Huang, Oswald Ndi Nfor, Yu-Chun Tung, Wen-Yuan Ku, Chun-Te Lee, Yung-Po Liaw
PURPOSE: Flunarizine (fz) and cinnarizine (cz) have well-known extrapyramidal side effects (EPSEs). The aim of this study was to evaluate the incidence and occurrence time of cz- and fz-related EPSEs. METHOD: Patients who took fz or cz for more than 1 month were identified from the longitudinal health insurance database 2005 and 2010. Excluded were patients with any of the underlying diseases that may cause parkinsonism. Drug-induced EPSEs were defined as the new diagnosis of parkinsonism, dyskinesia, or secondary dystonia during drug use or within 3 months after discontinuing the medication...
April 6, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28382498/assessing-the-relative-potency-of-s-and-r-warfarin-with-a-new-pk-pd-model-in-relation-to-vkorc1-genotypes
#12
Myriam Ferrari, Vittorio Pengo, Massimiliano Barolo, Fabrizio Bezzo, Roberto Padrini
PURPOSE: The purpose of this study is to develop a new pharmacokinetic-pharmacodynamic (PK-PD) model to characterise the contribution of (S)- and (R)-warfarin to the anticoagulant effect on patients in treatment with rac-warfarin. METHODS: Fifty-seven patients starting warfarin (W) therapy were studied, from the first dose and during chronic treatment at INR stabilization. Plasma concentrations of (S)- and (R)-W and INRs were measured 12, 36 and 60 h after the first dose and at steady state 12-14 h after dosing...
April 5, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28378058/meta-analysis-of-effects-of-abcb1-polymorphisms-on-clopidogrel-response-among-patients-with-coronary-artery-disease
#13
Yajing Zhai, Hairong He, Xiancang Ma, Jiao Xie, Ti Meng, Yalin Dong, Jun Lu
PURPOSE: The substantial variability in the antiplatelet efficacy of clopidogrel has raised major concerns. Molecular epidemiological research suggests that ABCB1 C3435T polymorphism may be associated with clopidogrel response, but results remain controversial. To derive a more precise evaluation of the associations between ABCB1 C3435T polymorphism and the clinical efficacy of clopidogrel, we have conducted a PRISMA-compliant meta-analysis. METHODS: The PubMed and EMBASE databases were searched for eligible studies up to 25 October 2016...
April 5, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28378057/tolerability-of-new-antiepileptic-drugs-a-network-meta-analysis
#14
REVIEW
Gaetano Zaccara, Fabio Giovannelli, Filippo Sean Giorgi, Valentina Franco, Sara Gasparini, Umberto Benedetto
OBJECTIVE: The objective of this study was to perform a comparative assessment of tolerability of all licensed new antiepileptic drugs (AEDs) through a network meta-analysis (NMA) including all placebo-controlled double-blind clinical trials (RCTs) in all conditions in which these drugs have been tested. METHODS: NMA with a frequentist approach was used to compare proportions of patients withdrawing because of adverse events (AEs). Analyses were conducted for all therapeutic doses pooled and specifically for high therapeutic doses...
April 4, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28374082/the-leukotriene-receptor-antagonist-montelukast-and-its-possible-role-in-the-cardiovascular-field
#15
REVIEW
Malvina Hoxha, G Enrico Rovati, Aurora Bueno Cavanillas
BACKGROUND: Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are pro-inflammatory mediators of the 5-lipooxygenase (5-LO) pathway, that play an important role in bronchoconstriction, but can also enhance endothelial cell permeability and myocardial contractility, and are involved in many other inflammatory conditions. In the late 1990s, leukotriene receptor antagonists (LTRAs) were introduced in therapy for asthma and later on, approved for the relief of the symptoms of allergic rhinitis, chronic obstructive pulmonary disease, and urticaria...
April 4, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28365794/response-randomised-trial-of-the-effect-of-a-gastrin-cck2-receptor-antagonist-on-esomeprazole-induced-hypergastrinaemia-evidence-against-rebound-hyperacidity
#16
LETTER
Malcolm Boyce, Frans van den Berg, Toni Mitchell, Kate Darwin, Steve Warrington
No abstract text is available yet for this article.
April 1, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28352949/from-prescription-only-rx-to-over-the-counter-otc-status-in-germany-2006-2015-pharmacological-perspectives-on-regulatory-decisions
#17
Eva Barrenberg, Edeltraut Garbe
PURPOSE: Little is known about the extent of switches from prescription-only (Rx) to over-the-counter (OTC) status in Europe and about the pharmacological properties of the switched substances. The objectives of this study were to provide an overview of the substances that were switched from Rx to OTC status in Germany between 2006 and 2015 and to assess their pharmacological properties. METHODS: Session minutes of the German Expert Advisory Committee for Prescription-Only Issues, changes to the German Ordinance on Prescription-Only Medicines and the Summary of Product Characteristics of the switched substances were analysed...
March 28, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28343258/variation-of-antibiotic-consumption-and-its-correlated-factors-in-turkey
#18
Ayfer Sahin, Ahmet Akici, Volkan Aydin, Bahar Melik, Mesil Aksoy, Ali Alkan
BACKGROUND: Presentation of antibiotic utilization data by reliable and comparable analyses constitutes an important way of ensuring rational use of antibiotics. This study aimed to evaluate antibiotic consumption (AC) of Turkey by each city/region and to investigate any association of such consumption with socio-economic factors. METHOD: For 81 provinces and 12 regions in Turkey, AC data from IMS (Intercontinental Medical Statistics) in 2011 was analyzed in accordance with "ATC/DDD, DID" (Anatomical Therapeutic Chemical/Defined Daily Doses, DID = DDD/1000 inhabitants/day) methodology supported by World Health Organization...
March 25, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28342067/the-incidence-of-post-transplant-cancer-among-kidney-transplant-recipients-is-associated-with-the-level-of-tacrolimus-exposure-during-the-first-year-after-transplantation
#19
Shelly Lichtenberg, Ruth Rahamimov, Hefziba Green, Benjamin D Fox, Eytan Mor, Uzi Gafter, Avry Chagnac, Benaya Rozen-Zvi
PURPOSE: Immunosuppressive therapy plays a major role in the development of post-transplant cancer. In this nested case-control study of kidney transplant recipients (KTRs), we investigated whether the incidence of post-transplant cancer is associated with the level of tacrolimus exposure over time. METHODS: We screened the Rabin Medical Center database for adults who received kidney transplants between 2001 and 2014 and developed post-transplant cancer (excluding basal and squamous cell skin cancers)...
March 24, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28342066/antidepressant-use-in-suicides-a-case-control-study-from-the-friuli-venezia-giulia-region-italy-2005-2014
#20
Giulio Castelpietra, Michele Gobbato, Francesca Valent, Clarissa De Vido, Matteo Balestrieri, Göran Isacsson
PURPOSE: To compare the use of antidepressant (AD) classes and compounds in individuals who committed suicide and in controls from the general population and to assess to what extent adherence and current use of different AD classes can affect the risk of committing suicide. METHODS: Individual data on suicide, diagnoses and AD use in Friuli Venezia Giulia from 2005 to 2014 were obtained from the Regional Social and Health Information System. All suicides that had at least one prescription of AD in the 730 days before death (N = 876) were included as cases...
March 24, 2017: European Journal of Clinical Pharmacology
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