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European Journal of Clinical Pharmacology

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https://www.readbyqxmd.com/read/29781049/effects-of-vitamin-k-epoxide-reductase-complex-1-gene-polymorphisms-on-warfarin-control-in-japanese-patients-with-left-ventricular-assist-devices-lvad
#1
Kazuki Nakagita, Kyoichi Wada, Yutaro Mukai, Takaya Uno, Ryoji Nishino, Sachi Matsuda, Hiromi Takenaka, Nobue Terakawa, Akira Oita, Mitsutaka Takada
PURPOSE: This study aimed to investigate relationships between times in therapeutic range (TTR) or warfarin sensitivity indexes (WSI) and VKORC1-1639G>A and CYP2C9 polymorphisms in patients with left ventricular assist devices (LVAD). METHODS: Severe heart failure patients who received LVAD from January 1, 2013 to October 31, 2017 were recruited. Relationships between TTR or WSI and VKORC1-1639G>A and CYP2C9 gene polymorphisms were investigated immediately after LVAD implantation (period 1) and immediately prior to hospital discharge (period 2)...
May 21, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29770840/similar-effect-of-quercetin-on-cyp2e1-and-cyp2c9-activities-in-humans
#2
LETTER
Shingen Misaka, Kenju Shimomura
No abstract text is available yet for this article.
May 17, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29770839/are-multidose-drug-dispensing-systems-initiated-for-the-appropriate-patients
#3
Bram J Mertens, H F Kwint, Rob J van Marum, Marcel L Bouvy
PURPOSE: It is unknown if multidose drug dispensing (MDD) systems are initiated for the appropriate patients. Therefore, the objective of this study was to compare the medication management problems of patients who were about to start with a MDD system (MDD patients) and patients who continued manually dispensed medication (non-MDD users) in order to identify if the appropriate patients receive a MDD system. METHODS: Patient interviews (semi-structured) were conducted by 44 community pharmacists at the patient's home...
May 16, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29756176/response-similar-effect-of-quercetin-on-cyp2e1-and-cyp2c9-activities-in-humans
#4
LETTER
Satish Kumar Bedada, Prasad Neerati
No abstract text is available yet for this article.
May 13, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29754217/investigation-of-factors-influencing-radioiodine-131-i-biokinetics-in-patients-with-benign-thyroid-disease-using-nonlinear-mixed-effects-approach
#5
Valentina Topić Vučenović, Zvezdana Rajkovača, Dijana Jelić, Dragi Stanimirović, Goran Vuleta, Branislava Miljković, Katarina Vučićević
PURPOSE: Radioiodine (131 I) therapy is the common treatment option for benign thyroid diseases. The objective of this study was to characterize 131 I biokinetics in patients with benign thyroid disease and to investigate and quantify the influence of patients' demographic and clinical characteristics on intra-thyroidal 131 I kinetics by developing a population model. METHODS: Population pharmacokinetic analysis was performed using a nonlinear mixed effects approach...
May 13, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29754216/the-patient-s-safety-and-access-to-experimental-drugs-after-the-termination-of-clinical-trials-regulations-and-trends
#6
Ricardo Eccard da Silva, Angélica Amorim Amato, Thiago do Rego Sousa, Marta Rodrigues de Carvalho, Maria Rita Carvalho Garbi Novaes
PURPOSE: Participants' rights and safety must be guaranteed not only while a clinical trial is being conducted but also when a clinical trial finishes. The criteria for post-trial access to experimental drugs, however, are unclear in various countries. The objectives of this study were (i) to ascertain if there were regulations or guidelines related to patients' access to drugs after the end of clinical trials in the countries selected in the study and (ii) to analyze trends in post-trial access in countries classified by their level of economic development...
May 12, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29754215/a-systematic-literature-review-on-strategies-to-avoid-look-alike-errors-of-labels
#7
REVIEW
Karin H M Larmené-Beld, E Kim Alting, Katja Taxis
PURPOSE: Unclear labeling has been recognized as an important cause of look-alike medication errors. The aim of this literature review is to systematically evaluate the current evidence on strategies to minimize medication errors due to look-alike labels. METHODS: A literature search of PubMed and EMBASE for all available years was performed independently by two reviewers. Original studies assessing strategies to minimize medication errors due to look-alike labels focusing on readability of labels by health professionals or consumers were included...
May 12, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29748863/repaglinide-irbesartan-drug-interaction-effects-of-slco1b1-polymorphism-on-repaglinide-pharmacokinetics-and-pharmacodynamics-in-chinese-population
#8
Qi Pei, Jun-Yan Liu, Ji-Ye Yin, Guo-Ping Yang, Shi-Kun Liu, Yi Zheng, Pan Xie, Cheng-Xian Guo, Mi Luo, Hong-Hao Zhou, Xi Li, Zhao-Qian Liu
PURPOSE: On account of the potential inhibition of OATP1B1 (organic anion transporting polypeptide) by angiotensin II receptor blockers (ARBs) and the effects of SLCO1B1 (solute carrier organic anion transporter family member) polymorphism, the aim of current study is to assess the impact of ARBs on the pharmacokinetics (PK) and pharmacodynamics (PD) of repaglinide in Chinese healthy volunteers with different SLCO1B1 genotypes. METHODS: The in vitro study was conducted on irbesartan, valsartan, olmesartan, and losartan by using HEK293 cells transfected with OATP1B1...
May 11, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29748862/association-of-dna-methylation-in-bdnf-with-escitalopram-treatment-response-in-depressed-chinese-han-patients
#9
Peipei Wang, Cuizhen Zhang, Qinyu Lv, Chenxi Bao, Hong Sun, Guo Ma, Yiru Fang, Zhenghui Yi, Weimin Cai
PURPOSE: The neurotrophin brain-derived neurotrophic factor (BDNF) has been found to be associated with both the pathophysiology of depression and antidepressants response. Gene expression differences were partly mediated by SNP, which might be identified as a predictor of antidepressant response. In the present study, we attempt to identify whether DNA methylation, another factor known to affect gene transcription, might also predict antidepressant response. METHODS: A total of 85 depressed Chinese Han patients were followed-up 8 weeks after initiating escitalopram treatment...
May 10, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29748861/response-to-the-letter-to-the-editor-by-dr-yasar-and-babaoglu-on-the-recent-publication-of-kokki-et-al-on-the-pharmacokinetics-of-metoprolol-bioavailability-in-coronary-artery-bypass-surgery-patients
#10
LETTER
Hannu Kokki, Jari Halonen, Juha Hartikainen
No abstract text is available yet for this article.
May 10, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29740677/extracorporeal-circulation-systems-in-coronary-artery-bypass-surgery-can-affect-pharmacokinetics-of-drugs-may-altered-cyp-mediated-liver-function-be-a-possible-reason
#11
LETTER
Umit Yasar, Melih O Babaoglu
No abstract text is available yet for this article.
May 9, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29740676/adverse-reactions-associated-with-first-line-regimens-in-patient-initiating-antiretroviral-therapy
#12
Jullye Campos Mendes, Palmira de Fátima Bonolo, Maria das Graças Braga Ceccato, Juliana de Oliveira Costa, Adriano Max Moreira Reis, Henrique Dos Santos, Micheline Rosa Silveira
OBJECTIVE: To evaluate the prevalence of adverse drug reactions (ADR) and associated factors during the use of Highly Active Antiretroviral Therapy (HAART) in patients initiating treatment. METHODS: This is a cross-sectional analysis of a prospective study conducted in three public referral services specialized in HIV/AIDS care in Belo Horizonte, Brazil. Self-reported ADR and explanatory variables were obtained from face-to-face interview and from Information Systems...
May 8, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29736825/bleeding-events-attributable-to-concurrent-use-of-warfarin-and-other-medications-in-high-risk-elderly-meta-analysis-and-italian-population-based-investigation
#13
Rosanna Irene Comoretto, Federico Rea, Ersilia Lucenteforte, Alessandro Mugelli, Gianluca Trifirò, Silvia Cascini, Giuseppe Roberto, Alessandro Chinellato, Amelia Filippelli, Giovanni Corrao
PURPOSE: The aim of this study was to estimate the proportion of bleedings that occurred among warfarin users attributable to the concomitant use of other medications. A general approach for measuring the impact of the prescriptive inappropriateness on drug adverse outcomes at the population level is described. METHODS: A meta-analysis was conducted to obtain summary relative risks of bleeding associated with concurrent use of warfarin and other medications compared to warfarin use alone...
May 7, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29732487/therapeutic-drug-monitoring-of-vancomycin-in-a-patient-on-extracorporeal-membrane-oxygenation-therapy-in-intensive-care-unit
#14
LETTER
L Herrera Hidalgo, A B Guisado Gil, M V Gil Navarro, L Martín Villén, Y Corcia Palomo, R Martín Bermúdez
No abstract text is available yet for this article.
May 7, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29725699/longer-term-breastfeeding-outcomes-associated-with-domperidone-use-for-lactation-differs-according-to-maternal-weight
#15
Luke E Grzeskowiak, Lisa H Amir, Lisa G Smithers
PURPOSE: To examine differences in longer-term breastfeeding outcomes among mothers of preterm infants according to domperidone exposure status, as well as examine the potential for effect modification according to maternal weight. METHODS: Retrospective cohort study of 198 mothers of very preterm infants (born ≤ 30 weeks' gestation) who initiated breastfeeding and whose infants survived until hospital discharge. Data on domperidone use were obtained from hospital pharmacy records, with the primary outcome defined as continuation of breastfeeding at infant discharge from the Neonatal Unit...
May 3, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29721582/darunavir-concentration-in-pbmcs-may-be-a-better-indicator-of-drug-exposure-in-hiv-patients
#16
Daisuke Nagano, Takuya Araki, Kunio Yanagisawa, Yoshiyuki Ogawa, Fumito Gohda, Hideki Uchiumi, Hiroshi Handa, Tomonori Nakamura, Koujirou Yamamoto
PURPOSE: The clinical efficacies of some antiretroviral drugs are known to not depend on its concentration in blood. To establish a method of dosage adjustment for darunavir (DRV) based on pharmacokinetic theory, we analyzed the correlation between DRV levels in peripheral blood mononuclear cells (PBMCs) and plasma. METHODS: The concentrations of DRV and ritonavir (RTV) in plasma and PBMCs of 31 samples obtained from 19 patients were analyzed. An in vitro kinetic study using MOLT-4 cells was performed to assess the contribution of RTV to the intracellular accumulation of DRV...
May 2, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29713800/effect-of-flunitrazepam-as-an-oral-hypnotic-on-24-hour-blood-pressure-in-healthy-volunteers
#17
Daniele Bosone, Roberto Fogari, Annalisa Zoppi, Angela D'Angelo, Natascia Ghiotto, Giulia Perini, Matteo Cotta Ramusino, Alfredo Costa
PURPOSE: The present study was carried out in order to assess the effects of chronic administration of flunitrazepam (as an oral hypnotic) on 24-h blood pressure (BP) and heart rate (HR) in healthy young adults. MATERIALS AND METHODS: Following a 2-week placebo run-in period, 28 healthy volunteers (13 males and 15 females) between 21 and 30 years were randomized to receive either flunitrazepam 1 mg or placebo (both administered once a day in the evening) for 4 weeks in two cross-over periods; each separated by a 2-week placebo period...
April 30, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29705821/higher-than-standard-meropenem-and-linezolid-dosages-needed-for-appropriate-treatment-of-an-intracerebral-hemorrhage-patient-with-augmented-renal-clearance
#18
LETTER
Pier Giorgio Cojutti, Cristina Barbarino, Amato De Monte, William Hope, Federico Pea
No abstract text is available yet for this article.
April 29, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29666903/high-isavuconazole-plasma-levels-in-a-patient-with-possible-invasive-pulmonary-aspergillosis-and-cirrhosis
#19
LETTER
Elena Arsiè, Stefania Piconi, Massimo Iavarone, Valeria Cozzi, Pietro Lampertico, Dario Cattaneo
No abstract text is available yet for this article.
April 18, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29666902/effect-of-cyp2c19-ugt1a8-and-ugt2b7-on-valproic-acid-clearance-in-children-with-epilepsy-a-population-pharmacokinetic-model
#20
Shenghui Mei, Weixing Feng, Leting Zhu, Xingang Li, Yazhen Yu, Weili Yang, Baoqin Gao, Xiaojuan Wu, Fang Fang, Zhigang Zhao
PURPOSE: Valproic acid (VPA) is an important drug in seizure control with great inter-individual differences in metabolism and treatment effect. This study aims to identify the effects of genetic variants on VPA clearance in a population pharmacokinetic (popPK) model in children with epilepsy. METHODS: A total of 325 VPA plasma concentrations from 290 children with epilepsy were used to develop the popPK model by using the nonlinear mixed-effects modeling method...
April 17, 2018: European Journal of Clinical Pharmacology
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