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Diabetologia

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https://www.readbyqxmd.com/read/28213757/germinal-centre-frequency-is-decreased-in-pancreatic-lymph-nodes-from-individuals-with-recent-onset-type-1-diabetes
#1
Abby Willcox, Sarah J Richardson, Lucy S K Walker, Sally C Kent, Noel G Morgan, Kathleen M Gillespie
AIMS/HYPOTHESIS: Pancreatic lymph nodes (PLNs) are critical sites for the initial interaction between islet autoantigens and autoreactive lymphocytes, but the histology of PLNs in tissue from individuals with type 1 diabetes has not been analysed in detail. The aim of this study was to examine PLN tissue sections from healthy donors compared with those at risk of, or with recent-onset and longer-duration type 1 diabetes. METHODS: Immunofluorescence staining was used to examine PLN sections from the following donor groups: non-diabetic (n=15), non-diabetic islet autoantibody-positive (n=5), recent-onset (≤1...
February 17, 2017: Diabetologia
https://www.readbyqxmd.com/read/28197657/gestational-diabetes-and-adverse-perinatal-outcomes-from-716-152-births-in-france-in-2012
#2
Cécile Billionnet, Delphine Mitanchez, Alain Weill, Jacky Nizard, François Alla, Agnès Hartemann, Sophie Jacqueminet
AIMS/HYPOTHESIS: The aim of this study was to assess the risk of adverse perinatal outcomes in gestational diabetes mellitus (GDM) in a large national cohort. METHODS: All deliveries taking place after 22 weeks in France in 2012 were included by extracting data from the hospital discharge database and the national health insurance system. The diabetic status of mothers was determined by the use of glucose-lowering agents and by hospital diagnosis. Outcomes were analysed according to the type of diabetes and, in the GDM group, whether or not diabetes was insulin-treated...
February 15, 2017: Diabetologia
https://www.readbyqxmd.com/read/28194484/perturbations-of-the-anti-ageing-hormone-klotho-in-patients-with-type-1-diabetes-and-microalbuminuria
#3
Giuseppe Maltese, Nikolaos Fountoulakis, Richard C Siow, Luigi Gnudi, Janaka Karalliedde
AIMS/HYPOTHESIS: Patients with type 1 diabetes and microalbuminuria are at high risk of cardiovascular disease (CVD) and end-stage renal disease. Soluble Klotho is an anti-ageing circulating hormone involved in phosphate metabolism and vascular homeostasis through protective effects on the endothelium and antioxidant actions. The role of soluble Klotho in patients with type 1 diabetes and microalbuminuria is unknown. METHODS: In a cross-sectional single-centre study we evaluated the levels of circulating serum soluble Klotho in 33 participants with type 1 diabetes and a history of microalbuminuria (receiving renin-angiotensin system [RAS] inhibitors) and 45 participants with type 1 diabetes without a history of microalbuminuria (not receiving RAS or other antihypertensive drugs)...
February 13, 2017: Diabetologia
https://www.readbyqxmd.com/read/28188334/aicar-ameliorates-high-fat-diet-associated-pathophysiology-in-mouse-and-ex-vivo-models-independent-of-adiponectin
#4
Emma Börgeson, Ville Wallenius, Gulam H Syed, Manjula Darshi, Juan Lantero Rodriguez, Christina Biörserud, Malin Ragnmark Ek, Per Björklund, Marianne Quiding-Järbrink, Lars Fändriks, Catherine Godson, Kumar Sharma
AIMS/HYPOTHESIS: In this study, we aimed to evaluate the therapeutic potential of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), an activator of AMP-activated protein kinase, for ameliorating high-fat diet (HFD)-induced pathophysiology in mice. We also aimed to determine whether the beneficial effects of AICAR were dependent on adiponectin. Furthermore, human adipose tissue was used to examine the effect of AICAR ex vivo. METHODS: Six-week-old male C57BL/6J wild-type and Adipoq (-/-) mice were fed a standard-fat diet (10% fat) or an HFD (60% fat) for 12 weeks and given vehicle or AICAR (500 μg/g) three times/week from weeks 4-12...
February 10, 2017: Diabetologia
https://www.readbyqxmd.com/read/28184960/genetic-evidence-of-a-causal-effect-of-insulin-resistance-on-branched-chain-amino-acid-levels
#5
Yuvaraj Mahendran, Anna Jonsson, Christian T Have, Kristine H Allin, Daniel R Witte, Marit E Jørgensen, Niels Grarup, Oluf Pedersen, Tuomas O Kilpeläinen, Torben Hansen
AIMS/HYPOTHESIS: Fasting plasma levels of branched-chain amino acids (BCAAs) are associated with insulin resistance, but it remains unclear whether there is a causal relation between the two. We aimed to disentangle the causal relations by performing a Mendelian randomisation study using genetic variants associated with circulating BCAA levels and insulin resistance as instrumental variables. METHODS: We measured circulating BCAA levels in blood plasma by NMR spectroscopy in 1,321 individuals from the ADDITION-PRO cohort...
February 10, 2017: Diabetologia
https://www.readbyqxmd.com/read/28175964/painting-a-new-picture-of-personalised-medicine-for-diabetes
#6
REVIEW
Mark I McCarthy
The current focus on delivery of personalised (or precision) medicine reflects the expectation that developments in genomics, imaging and other domains will extend our diagnostic and prognostic capabilities, and enable more effective targeting of current and future preventative and therapeutic options. The clinical benefits of this approach are already being realised in rare diseases and cancer but the impact on management of complex diseases, such as type 2 diabetes, remains limited. This may reflect reliance on inappropriate models of disease architecture, based around rare, high-impact genetic and environmental exposures that are poorly suited to our emerging understanding of type 2 diabetes...
February 7, 2017: Diabetologia
https://www.readbyqxmd.com/read/28160092/combined-nox1-4-inhibition-with-gkt137831-in-mice-provides-dose-dependent-reno-and-atheroprotection-even-in-established-micro-and-macrovascular-disease
#7
Stephen P Gray, Jay C Jha, Kit Kennedy, Erik van Bommel, Phyllis Chew, Cedric Szyndralewiez, Rhian M Touyz, Harald H H W Schmidt, Mark E Cooper, Karin A M Jandeleit-Dahm
AIMS/HYPOTHESIS: Oxidative stress is a promising target in diabetes-associated vasculopathies, with inhibitors of NADPH oxidases (NOX), in particular isoforms 1 and 4, shown to be safe in early clinical development. We have explored a highly relevant late-stage intervention protocol using the clinically most advanced compound, the NOX1/4 inhibitor GKT137831, to determine whether end-organ damage can be reversed/attenuated when GKT137831 is administered in the setting of established diabetic complications...
February 3, 2017: Diabetologia
https://www.readbyqxmd.com/read/28144712/peripheral-insulin-resistance-rather-than-beta-cell-dysfunction-accounts-for-geographical-differences-in-impaired-fasting-blood-glucose-among-sub-saharan-african-individuals-findings-from-the-rodam-study
#8
Karlijn A C Meeks, Karien Stronks, Adebowale Adeyemo, Juliet Addo, Silver Bahendeka, Erik Beune, Ellis Owusu-Dabo, Ina Danquah, Cecilia Galbete, Peter Henneman, Kerstin Klipstein-Grobusch, Frank P Mockenhaupt, Kwame Osei, Matthias B Schulze, Joachim Spranger, Liam Smeeth, Charles Agyemang
AIMS/HYPOTHESIS: The aim of this study was to assess the extent to which insulin resistance and beta cell dysfunction account for differences in impaired fasting blood glucose (IFBG) levels in sub-Saharan African individuals living in different locations in Europe and Africa. We also aimed to identify determinants associated with insulin resistance and beta cell dysfunction among this population. METHODS: Data from the cross-sectional multicentre Research on Obesity and Diabetes among African Migrants (RODAM) study were analysed...
January 31, 2017: Diabetologia
https://www.readbyqxmd.com/read/28144711/referees-2016
#9
(no author information available yet)
No abstract text is available yet for this article.
January 31, 2017: Diabetologia
https://www.readbyqxmd.com/read/28132100/towards-a-systematic-nationwide-screening-strategy-for-mody
#10
EDITORIAL
Beverley Shields, Kevin Colclough
MODY is an early-onset monogenic form of diabetes. Correctly identifying MODY is of considerable importance as diagnosing the specific genetic subtype can inform the optimal treatment, with many patients being able to discontinue unnecessary insulin treatment. Diagnostic molecular genetic testing to confirm MODY is expensive, so screening strategies are required to identify the most appropriate patients for testing. In this issue of Diabetologia, Johansson and colleagues (DOI 10.1007/s00125-016-4167-1 ) describe a nationwide systematic screening approach to identify individuals with MODY in the paediatric age range...
January 29, 2017: Diabetologia
https://www.readbyqxmd.com/read/28132099/pcsk9-inhibition-and-the-global-diabetes-epidemic
#11
LETTER
Luca Mascitelli, Mark R Goldstein
No abstract text is available yet for this article.
January 29, 2017: Diabetologia
https://www.readbyqxmd.com/read/28127622/differential-methylation-of-genes-in-individuals-exposed-to-maternal-diabetes-in-utero
#12
Peng Chen, Paolo Piaggi, Michael Traurig, Clifton Bogardus, William C Knowler, Leslie J Baier, Robert L Hanson
AIMS/HYPOTHESIS: Individuals exposed to maternal diabetes in utero are more likely to develop metabolic and cardiovascular diseases later in life. This may be partially attributable to epigenetic regulation of gene expression. We performed an epigenome-wide association study to examine whether differential DNA methylation, a major source of epigenetic regulation, can be observed in offspring of mothers with type 2 diabetes during the pregnancy (OMD) compared with offspring of mothers with no diabetes during the pregnancy (OMND)...
January 26, 2017: Diabetologia
https://www.readbyqxmd.com/read/28124081/lifestyle-and-precision-diabetes-medicine-will-genomics-help-optimise-the-prediction-prevention-and-treatment-of-type-2-diabetes-through-lifestyle-therapy
#13
REVIEW
Paul W Franks, Alaitz Poveda
Precision diabetes medicine, the optimisation of therapy using patient-level biomarker data, has stimulated enormous interest throughout society as it provides hope of more effective, less costly and safer ways of preventing, treating, and perhaps even curing the disease. While precision diabetes medicine is often framed in the context of pharmacotherapy, using biomarkers to personalise lifestyle recommendations, intended to lower type 2 diabetes risk or to slow progression, is also conceivable. There are at least four ways in which this might work: (1) by helping to predict a person's susceptibility to adverse lifestyle exposures; (2) by facilitating the stratification of type 2 diabetes into subclasses, some of which may be prevented or treated optimally with specific lifestyle interventions; (3) by aiding the discovery of prognostic biomarkers that help guide timing and intensity of lifestyle interventions; (4) by predicting treatment response...
January 25, 2017: Diabetologia
https://www.readbyqxmd.com/read/28116460/enhanced-vegf-signalling-mediates-cerebral-neovascularisation-via-downregulation-of-guidance-protein-robo4-in-a-rat-model-of-diabetes
#14
Mohammed Abdelsaid, Maha Coucha, Sherif Hafez, Abdul Yasir, Maribeth H Johnson, Adviye Ergul
AIMS/HYPOTHESIS: Diabetes promotes cerebral neovascularisation via increased vascular endothelial growth factor (VEGF) angiogenic signalling. Roundabout-4 (ROBO4) protein is an endogenous inhibitor of VEGF signalling that stabilises the vasculature. Yet, how diabetes affects ROBO4 function remains unknown. We hypothesised that increased VEGF signalling in diabetes decreases ROBO4 expression and function via binding of ROBO4 with VEGF-activated β3 integrin and that restoration of ROBO4 expression prevents/repairs cerebral neovascularisation in diabetes...
January 23, 2017: Diabetologia
https://www.readbyqxmd.com/read/28111711/re-addressing-the-2013-consensus-guidelines-for-the-diagnosis-of-insulitis-in-human-type-1-diabetes-is-change-necessary-reply-to-campbell-thompson-ml-atkinson-ma-butler-ae-et-al-letter
#15
LETTER
Marcus Lundberg, Peter Seiron, Sofie Ingvast, Olle Korsgren, Oskar Skog
No abstract text is available yet for this article.
January 22, 2017: Diabetologia
https://www.readbyqxmd.com/read/28105520/type-1-diabetic-patients-with-peripheral-neuropathy-have-pan-enteric-prolongation-of-gastrointestinal-transit-times-and-an-altered-caecal-ph-profile
#16
Adam D Farmer, Anne Grave Pedersen, Birgitte Brock, Poul Erik Jakobsen, Jesper Karmisholt, Sahar D Mohammed, S Mark Scott, Asbjørn Mohr Drewes, Christina Brock
AIMS/HYPOTHESIS: We hypothesised that type 1 diabetic patients with established diabetic sensorimotor polyneuropathy (DSPN) would have segmental and/or pan-enteric dysmotility in comparison to healthy age-matched controls. We aimed to investigate the co-relationships between gastrointestinal function, degree of DSPN and clinical symptoms. METHODS: An observational comparison was made between 48 patients with DSPN (39 men, mean age 50 years, range 29-71 years), representing the baseline data of an ongoing clinical trial (representing a secondary analysis of baseline data collected from an ongoing double-blind randomised controlled trial investigating the neuroprotective effects of liraglutide) and 41 healthy participants (16 men, mean age 49 years, range 30-78) who underwent a standardised wireless motility capsule test to assess gastrointestinal transit...
January 20, 2017: Diabetologia
https://www.readbyqxmd.com/read/28105519/translating-hba1c-measurements-into-estimated-average-glucose-values-in-pregnant-women-with-diabetes
#17
Graham R Law, Mark S Gilthorpe, Anna L Secher, Rosemary Temple, Rudolf Bilous, Elisabeth R Mathiesen, Helen R Murphy, Eleanor M Scott
AIMS/HYPOTHESIS: This study aimed to examine the relationship between average glucose levels, assessed by continuous glucose monitoring (CGM), and HbA1c levels in pregnant women with diabetes to determine whether calculations of standard estimated average glucose (eAG) levels from HbA1c measurements are applicable to pregnant women with diabetes. METHODS: CGM data from 117 pregnant women (89 women with type 1 diabetes; 28 women with type 2 diabetes) were analysed...
January 19, 2017: Diabetologia
https://www.readbyqxmd.com/read/28105518/associations-between-hepatic-mirna-expression-liver-triacylglycerols-and-gut-microbiota-during-metabolic-adaptation-to-high-fat-diet-in-mice
#18
Vincent Blasco-Baque, Berengère Coupé, Aurelie Fabre, Sandra Handgraaf, Pierre Gourdy, Jean-François Arnal, Michael Courtney, Carole Schuster-Klein, Beatrice Guardiola, François Tercé, Rémy Burcelin, Matteo Serino
AIMS/HYPOTHESIS: Despite the current pandemic of metabolic diseases, our understanding of the diverse nature of the development of metabolic alterations in people who eat a high-fat diet (HFD) is still poor. We recently demonstrated a cardio-metabolic adaptation in mice fed an HFD, which was characterised by a specific gut and periodontal microbiota profile. Since the severity of hepatic disease is characterised by specific microRNA (miRNA) signatures and the gut microbiota is a key driver of both hepatic disease and miRNA expression, we analysed the expression of three hepatic miRNA and studied their correlation with hepatic triacylglycerol content and gut microbiota...
January 19, 2017: Diabetologia
https://www.readbyqxmd.com/read/28102434/low-muscle-mass-and-risk-of-type-2-diabetes-in-middle-aged-and-older-adults-findings-from-the-koges
#19
Jang Won Son, Seong Su Lee, Sung Rae Kim, Soon Jib Yoo, Bong Yun Cha, Ho Young Son, Nam H Cho
AIMS/HYPOTHESIS: Asians have a propensity to develop type 2 diabetes with a lower BMI than Western populations. This discrepancy may be due to differences in body fat and muscle mass for a given BMI. However, unlike adiposity, it is unclear whether muscle mass affects the risk of type 2 diabetes in Asian populations. METHODS: We conducted a 2-yearly prospective assessment of 6895 participants who were free of diabetes at the baseline examination as part of the Korean Genome Epidemiology Study...
January 19, 2017: Diabetologia
https://www.readbyqxmd.com/read/28083635/inflammation-and-n-formyl-peptide-receptors-mediate-the-angiogenic-activity-of-human-vitreous-humour-in-proliferative-diabetic-retinopathy
#20
Sara Rezzola, Michela Corsini, Paola Chiodelli, Anna Cancarini, Imtiaz M Nawaz, Daniela Coltrini, Stefania Mitola, Roberto Ronca, Mirella Belleri, Liliana Lista, Dario Rusciano, Mario De Rosa, Vincenzo Pavone, Francesco Semeraro, Marco Presta
AIMS/HYPOTHESIS: Angiogenesis and inflammation characterise proliferative diabetic retinopathy (PDR), a major complication of diabetes mellitus. However, the impact of inflammation on the pathogenesis of PDR neovascularisation has not been elucidated. Here, we assessed the capacity of PDR vitreous fluid to induce pro-angiogenic/proinflammatory responses in endothelium and the contribution of the inflammation-related pattern recognition N-formyl peptide receptors (FPRs) in mediating these responses...
January 13, 2017: Diabetologia
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