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Mathilde Fraty, Gilberto Velho, Elise Gand, Fréderic Fumeron, Stéphanie Ragot, Philippe Sosner, Kamel Mohammedi, Barnabas Gellen, Pierre-Jean Saulnier, Jean-Michel Halimi, David Montaigne, Grégory Ducrocq, Michaela Rehman, Michel Marre, Ronan Roussel, Samy Hadjadj
AIMS/HYPOTHESIS: N-terminal pro-B-type natriuretic peptide (NT-proBNP) is the gold standard prognostic biomarker for diagnosis and occurrence of heart failure. Here, we compared its prognostic value for the occurrence of congestive heart failure with that of plasma mid-region pro-adrenomedullin (MR-proADM), a surrogate for adrenomedullin, a vasoactive peptide with vasodilator and natriuretic properties, in people with type 2 diabetes. METHODS: Plasma MR-proADM concentration was measured in baseline samples of a hospital-based cohort of consecutively recruited participants with type 2 diabetes...
September 19, 2018: Diabetologia
Maggie H Shepherd, Beverley M Shields, Michelle Hudson, Ewan R Pearson, Christopher Hyde, Sian Ellard, Andrew T Hattersley, Kashyap A Patel
AIMS/HYPOTHESIS: Treatment change following a genetic diagnosis of MODY is frequently indicated, but little is known about the factors predicting future treatment success. We therefore conducted the first prospective study to determine the impact of a genetic diagnosis on individuals with GCK-, HNF1A- or HNF4A-MODY in the UK, and to identify clinical characteristics predicting treatment success (i.e. HbA1c ≤58 mmol/mol [≤7.5%]) with the recommended treatment at 2 years. METHODS: This was an observational, prospective, non-selective study of individuals referred to the Exeter Molecular Genetic Laboratory for genetic testing from December 2010 to December 2012...
September 18, 2018: Diabetologia
Maija Feodoroff, Valma Harjutsalo, Carol Forsblom, Per-Henrik Groop
AIMS/HYPOTHESIS: The aim of this study was to assess the potential dose-dependent effects of smoking on the risk of CHD, heart failure and stroke in individuals with type 1 diabetes. METHODS: The study included 4506 individuals with type 1 diabetes who were participating in the Finnish Diabetic Nephropathy (FinnDiane) study. Intensity of smoking was estimated by packs per day and cumulative smoking by pack-years. Cox regression analyses were used to estimate the risk of incident CHD, heart failure or stroke during follow-up...
September 18, 2018: Diabetologia
(no author information available yet)
No abstract text is available yet for this article.
September 17, 2018: Diabetologia
Claudia H T Tam, Ronald C W Ma, Lai Yuk Yuen, Risa Ozaki, Albert Martin Li, Yong Hou, Michael H M Chan, Chung Shun Ho, Xilin Yang, Juliana C N Chan, Wing Hung Tam
AIMS/HYPOTHESIS: Accumulating evidence suggests an impact of gestational weight gain (GWG) on pregnancy outcomes; however, data on cardiometabolic risk factors later in life have not been comprehensively studied. This study aimed to evaluate the relationship between GWG and cardiometabolic risk in offspring aged 7 years. METHODS: We included a total of 905 mother-child pairs who enrolled in the follow-up visit of the multicentre Hyperglycemia and Adverse Pregnancy Outcome study, at the Hong Kong Centre...
September 17, 2018: Diabetologia
Chantal Mathieu, Riitta Lahesmaa, Ezio Bonifacio, Peter Achenbach, Timothy Tree
Immune biomarkers of type 1 diabetes are many and diverse. Some of these, such as the autoantibodies, are well established but not discriminative enough to deal with the heterogeneity inherent to type 1 diabetes progression. As an alternative, high hopes are placed on T cell assays, which give insight into the cells that actually target the beta cell or play a crucial role in maintaining tolerance. These assays are approaching a level of robustness that may allow for solid conclusions on both disease progression and therapeutic efficacy of immune interventions...
September 12, 2018: Diabetologia
Jeroen H P M van der Velde, Nicolaas C Schaper, Coen D A Stehouwer, Carla J H van der Kallen, Simone J S Sep, Miranda T Schram, Ronald M A Henry, Pieter C Dagnelie, Simone J P M Eussen, Martien C J M van Dongen, Hans H C M Savelberg, Annemarie Koster
AIMS/HYPOTHESES: Our aim was to examine the independent and combined (cross-sectional) associations of sedentary time (ST), higher intensity physical activity (HPA) and cardiorespiratory fitness (CRF) with metabolic syndrome and diabetes status. METHODS: In 1933 adults (aged 40-75 years) ST and HPA (surrogate measure for moderate to vigorous physical activity) were measured with the activPAL3. CRF was assessed by submaximal cycle-ergometer testing. Metabolic syndrome was defined according to the Adult Treatment Panel (ATP) III guidelines...
September 10, 2018: Diabetologia
María L Villanueva-Peñacarrillo
No abstract text is available yet for this article.
September 3, 2018: Diabetologia
Jessica L Harding, Meda E Pavkov, Dianna J Magliano, Jonathan E Shaw, Edward W Gregg
In recent decades, large increases in diabetes prevalence have been demonstrated in virtually all regions of the world. The increase in the number of people with diabetes or with a longer duration of diabetes is likely to alter the disease profile in many populations around the globe, particularly due to a higher incidence of diabetes-specific complications, such as kidney failure and peripheral arterial disease. The epidemiology of other conditions frequently associated with diabetes, including infections and cardiovascular disease, may also change, with direct effects on quality of life, demands on health services and economic costs...
August 31, 2018: Diabetologia
Thenmalar Vadiveloo, William Jeffcoate, Peter T Donnan, Helen C Colhoun, Stuart McGurnaghan, Sarah Wild, Rory McCrimmon, Graham P Leese
AIMS/HYPOTHESIS: Our aim was to investigate amputation-free survival in people at high risk for foot ulceration in diabetes ('high-risk foot'), and to compare different subcategories of high-risk foot. METHODS: Overall, 17,353 people with diabetes and high-risk foot from January 2008 to December 2011 were identified from the Scotland-wide diabetes register (Scottish Care Information-Diabetes: N = 247,278). Participants were followed-up for up to 2 years from baseline and were categorised into three groups: (1) those with no previous ulcer, (2) those with an active ulcer or (3) those with a healed previous ulcer...
August 31, 2018: Diabetologia
Susanne M Cabrera, Samuel Engle, Mary Kaldunski, Shuang Jia, Rhonda Geoffrey, Pippa Simpson, Aniko Szabo, Cate Speake, Carla J Greenbaum, Yi-Guang Chen, Martin J Hessner
AIMS/HYPOTHESIS: The study aimed to determine whether discrete subtypes of type 1 diabetes exist, based on immunoregulatory profiles at clinical onset, as this has significant implications for disease treatment and prevention as well as the design and analysis of clinical trials. METHODS: Using a plasma-based transcriptional bioassay and a gene-ontology-based scoring algorithm, we examined local participants from the Children's Hospital of Wisconsin and conducted an ancillary analysis of TrialNet CTLA4-Ig trial (TN-09) participants...
August 30, 2018: Diabetologia
John M Wentworth, Naiara G Bediaga, Lynne C Giles, Mario Ehlers, Stephen E Gitelman, Susan Geyer, Carmella Evans-Molina, Leonard C Harrison
AIMS/HYPOTHESIS: Beta cell function in type 1 diabetes is commonly assessed as the average plasma C-peptide concentration over 2 h following a mixed-meal test (CPAVE ). Monitoring of disease progression and response to disease-modifying therapy would benefit from a simpler, more convenient and less costly measure. Therefore, we determined whether CPAVE could be reliably estimated from routine clinical variables. METHODS: Clinical and fasting biochemical data from eight randomised therapy trials involving participants with recently diagnosed type 1 diabetes were used to develop and validate linear models to estimate CPAVE and to test their accuracy in estimating loss of beta cell function and response to immune therapy...
August 30, 2018: Diabetologia
Ian J Neeland, Shruti Singh, Darren K McGuire, Gloria L Vega, Thomas Roddy, Dermot F Reilly, Jose Castro-Perez, Julia Kozlitina, Philipp E Scherer
AIMS/HYPOTHESIS: Ceramides are sphingolipids that contribute to insulin resistance in preclinical studies. We hypothesised that plasma ceramides would be associated with body fat distribution, insulin resistance and incident type 2 diabetes in a multi-ethnic cohort. METHODS: A total of 1557 participants in the Dallas Heart Study without type 2 diabetes underwent measurements of metabolic biomarkers, fat depots by MRI and plasma ceramides by liquid chromatography-mass spectrometry...
August 29, 2018: Diabetologia
Ghazaleh Hajmousa, Ewa Przybyt, Frederick Pfister, Genaro A Paredes-Juarez, Kondaiah Moganti, Stephanie Busch, Jeroen Kuipers, Ingeborg Klaassen, Marja J A van Luyn, Guido Krenning, Hans-Peter Hammes, Martin C Harmsen
AIMS/HYPOTHESIS: The immunomodulatory capacity of adipose tissue-derived stromal cells (ASCs) is relevant for next-generation cell therapies that aim to reverse tissue dysfunction such as that caused by diabetes. Pericyte dropout from retinal capillaries underlies diabetic retinopathy and the subsequent aberrant angiogenesis. METHODS: We investigated the pericytic function of ASCs after intravitreal injection of ASCs in mice with retinopathy of prematurity as a model for clinical diabetic retinopathy...
August 27, 2018: Diabetologia
Kimberly J Nahon, Fleur Doornink, Maaike E Straat, Kani Botani, Borja Martinez-Tellez, Gustavo Abreu-Vieira, Jan B van Klinken, Gardi J Voortman, Edith C H Friesema, Jonatan R Ruiz, Floris H P van Velden, Lioe-Fee de Geus-Oei, Frits Smit, Lenka M Pereira Arias-Bouda, Jimmy F P Berbée, Ingrid M Jazet, Mariëtte R Boon, Patrick C N Rensen
AIMS/HYPOTHESIS: The aim of this study was to evaluate the effect of sitagliptin on glucose tolerance, plasma lipids, energy expenditure and metabolism of brown adipose tissue (BAT), white adipose tissue (WAT) and skeletal muscle in overweight individuals with prediabetes (impaired glucose tolerance and/or impaired fasting glucose). METHODS: We performed a randomised, double-blinded, placebo-controlled trial in 30 overweight, Europid men (age 45.9 ± 6.2 years; BMI 28...
August 25, 2018: Diabetologia
Gary W Cline, Timothy J McCarthy, Richard E Carson, Roberto A Calle
No abstract text is available yet for this article.
August 22, 2018: Diabetologia
Claudia R L Cardoso, Juliana V Melo, Guilherme C Salles, Nathalie C Leite, Gil F Salles
AIMS/HYPOTHESIS: The prognostic importance of the ankle-brachial index (ABI) in individuals with diabetes is controversial. We aimed to evaluate the relationship between the ABI and the occurrence of micro- and macrovascular complications in individuals with type 2 diabetes. METHODS: The ABI was measured at baseline in 668 individuals with type 2 diabetes, and the individuals were followed-up for a median of 10 years. Multivariate Cox analysis was used to examine associations between the ABI and the occurrence of microvascular (retinopathy, microalbuminuria, renal function deterioration and peripheral neuropathy) and macrovascular (total cardiovascular events, major adverse cardiovascular events [MACE] and cardiovascular mortality) complications, and all-cause mortality...
August 15, 2018: Diabetologia
Ravi Retnakaran, Chang Ye, Caroline K Kramer, Anthony J Hanley, Philip W Connelly, Mathew Sermer, Bernard Zinman
AIMS/HYPOTHESIS: The prevalence of gestational diabetes (GDM) is higher in summer months, possibly reflecting an association between ambient temperature and blood glucose levels. However, the specific exposure and mechanism by which temperature may affect glucose metabolism in pregnancy remains unclear. We systematically evaluated the relationships of environmental temperature and changes therein over varying durations of exposure time with beta cell function, insulin sensitivity and glucose tolerance in women undergoing antepartum screening for GDM...
August 15, 2018: Diabetologia
Rosemary E McDowell, Peter Barabas, Josy Augustine, Olivier Chevallier, Philip McCarron, Mei Chen, J Graham McGeown, Tim M Curtis
AIMS/HYPOTHESIS: Recent studies suggest that abnormal function in Müller glial cells plays an important role in the pathogenesis of diabetic retinopathy. This is associated with the selective accumulation of the acrolein-derived advanced lipoxidation end-product, Nε -(3-formyl-3,4-dehydropiperidino)lysine (FDP-lysine), on Müller cell proteins. The aim of the current study was to identify more efficacious acrolein-scavenging drugs and determine the effects of the most potent on Müller cell FDP-lysine accumulation and neuroretinal dysfunction during diabetes...
August 15, 2018: Diabetologia
Emily K Sims, Carmella Evans-Molina, Sarah A Tersey, Decio L Eizirik, Raghavendra G Mirmira
Recent work on the pathogenesis of type 1 diabetes has led to an evolving recognition of the heterogeneity of this disease, both with regards to clinical phenotype and responses to therapies to prevent or revert diabetes. This heterogeneity not only limits efforts to accurately predict clinical disease but also is reflected in differing responses to immunomodulatory therapeutics. Thus, there is a need for robust biomarkers of beta cell health, which could provide insight into pathophysiological differences in disease course, improve disease prediction, increase the understanding of therapeutic responses to immunomodulatory interventions and identify individuals most likely to benefit from these therapies...
August 15, 2018: Diabetologia
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