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American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation

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https://www.readbyqxmd.com/read/30639233/muscle-relaxant-use-among-hemodialysis-patients-prevalence-clinical-indications-and-adverse-outcomes
#1
Diana Mina, Kirsten L Johansen, Charles E McCulloch, Michael A Steinman, Barbara A Grimes, Julie H Ishida
RATIONALE & OBJECTIVE: Muscle relaxants are often used to treat musculoskeletal pain or cramping, which are commonly experienced by hemodialysis patients. However, the extent to which muscle relaxants are prescribed in this population and the risks associated with their use have not been characterized. STUDY DESIGN: Observational cohort study. SETTING & PARTICIPANTS: 140,899 Medicare-covered adults receiving hemodialysis in 2011, identified in the US Renal Data System...
January 10, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30616872/anemia-in-non-dialysis-dependent-ckd-to-treat-or-not-to-treat
#2
EDITORIAL
Steven Fishbane, Daniel W Ross, Susana Hong
No abstract text is available yet for this article.
January 4, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30611600/calcimimetics-and-bundled-reimbursement
#3
Eugene Lin, Suzanne Watnick
Since 2011, the Centers for Medicare & Medicaid Services has provided reimbursement for renal dialysis services furnished to Medicare beneficiaries through a bundled payment system known as the Prospective Payment System. Medications that have no injectable equivalent, known as "oral-only medications," are currently excluded from the bundle and are paid separately through Medicare Part D. Thus, before the development of etelcalcetide, the first injectable calcimimetic, calcimimetics were reimbursed outside the bundle...
January 3, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30600106/acute-kidney-injury-due-to-ovarian-hyperstimulation-syndrome
#4
Rima Abou Arkoub, Cheng Wei Xiao, Paul Claman, Edward G Clark
Ovarian hyperstimulation syndrome (OHSS) is a complication of assisted reproductive treatments such as in vitro fertilization (IVF). The pathophysiology of severe OHSS includes a humorally mediated capillary leak syndrome that is predominantly centered on the intra-abdominal space. Severe OHSS is frequently complicated by acute kidney injury (AKI), which can be due to any of a variety of mechanisms, each requiring a different management strategy. Mechanisms of AKI in severe OHSS include intravascular volume depletion, kidney edema due to capillary leak, intra-abdominal hypertension or compartment syndrome, and obstructive uropathy due to ovarian enlargement...
December 29, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30600105/erratum-regarding-phosphorus-content-of-popular-beverages-am-j-kidney-dis-2015-65-6-969-971
#5
(no author information available yet)
No abstract text is available yet for this article.
December 29, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30600104/addressing-the-need-for-clinical-trial-end-points-in-autosomal-dominant-polycystic-kidney-disease-a-report-from-the-polycystic-kidney-disease-outcomes-consortium-pkdoc
#6
Kimberly A Smith, Aliza M Thompson, David A Baron, Steven T Broadbent, Gary H Lundstrom, Ronald D Perrone
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. Expansion of multiple cysts throughout both kidneys is thought to lead to progressive loss of kidney function and kidney failure in some patients. In recent years, much has been learned about the pathophysiology of ADPKD. However, to date, only one therapy has been approved in the United States and in other regions for the treatment of ADPKD. Feasible end points and a clear regulatory pathway may stimulate further development in this area and ultimately lead to more treatments for ADPKD successfully reaching the market...
December 29, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30598348/the-us-renal-data-system-at-30-years-a-historical-perspective
#7
EDITORIAL
Friedrich K Port, Philip J Held
No abstract text is available yet for this article.
December 28, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30598347/routine-laboratory-testing-every-4-versus-every-6-weeks-for-patients-on-maintenance-hemodialysis-a-quality-improvement-project
#8
Samuel A Silver, Abdullah Alaryni, Abdullah Alghamdi, Genevieve Digby, Ron Wald, Eduard Iliescu
RATIONALE & OBJECTIVE: Few data exist revealing how the frequency of routine blood work for patients on maintenance hemodialysis therapy affects patient outcomes and the costs of care. Our objective was to determine the effect of changing the frequency of blood work from 4- to 6-week intervals on the achievement of anemia and chronic kidney disease-mineral and bone disorder (CKD-MBD) targets. STUDY DESIGN: Retrospective interrupted time series from June 1, 2012, to December 31, 2015...
December 28, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30579710/development-of-an-international-standard-set-of-value-based-outcome-measures-for-patients-with-chronic-kidney-disease-a-report-of-the-international-consortium-for-health-outcomes-measurement-ichom-ckd-working-group
#9
Wouter R Verberne, Zofia Das-Gupta, Andrew S Allegretti, Hans A J Bart, Wim van Biesen, Guillermo García-García, Elizabeth Gibbons, Eduardo Parra, Marc H Hemmelder, Kitty J Jager, Markus Ketteler, Charlotte Roberts, Muhamed Al Rohani, Matthew J Salt, Andrea Stopper, Türkan Terkivatan, Katherine R Tuttle, Chih-Wei Yang, David C Wheeler, Willem Jan W Bos
Value-based health care is increasingly promoted as a strategy for improving care quality by benchmarking outcomes that matter to patients relative to the cost of obtaining those outcomes. To support the shift toward value-based health care in chronic kidney disease (CKD), the International Consortium for Health Outcomes Measurement (ICHOM) assembled an international working group of health professionals and patient representatives to develop a standardized minimum set of patient-centered outcomes targeted for clinical use...
December 19, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30578153/determinants-of-urine-volume-in-adpkd-patients-using-the-vasopressin-v2-receptor-antagonist-tolvaptan
#10
Bart J Kramers, Maatje D A van Gastel, Wendy E Boertien, Esther Meijer, Ron T Gansevoort
RATIONALE & OBJECTIVE: The vasopressin V2 receptor antagonist (V2RA) tolvaptan is the first drug that has been shown to slow the rate of kidney function decline in patients with autosomal dominant polycystic kidney disease (ADPKD). However, V2RAs also cause polyuria, with urine output that averages 6L/d. We assessed determinants of urine volume in patients with ADPKD using V2RAs because such information may help develop strategies to improve V2RA tolerability. STUDY DESIGN: Clinical trial of patients with ADPKD studied at baseline, after 3 weeks of V2RA treatment (tolvaptan, 90/30mg, in the last week), and after a 3-week washout period...
December 19, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30578152/treatment-of-anemia-with-darbepoetin-prior-to-dialysis-initiation-and-clinical-outcomes-analyses-from-the-trial-to-reduce-cardiovascular-events-with-aranesp-therapy-treat
#11
Finnian R Mc Causland, Brian Claggett, Emmanuel A Burdmann, Glenn M Chertow, Mark E Cooper, Kai-Uwe Eckardt, Peter Ivanovich, Andrew S Levey, Eldrin F Lewis, Janet B McGill, John J V McMurray, Patrick Parfrey, Hans-Henrik Parving, Giuseppe Remuzzi, Ajay K Singh, Scott D Solomon, Robert D Toto, Marc A Pfeffer
RATIONALE & OBJECTIVE: Evidence from clinical trials to guide patient preparation for maintenance dialysis therapy is limited. Although anemia is associated with mortality and cardiovascular (CV) disease in individuals initiating maintenance dialysis therapy, it is not known if treatment of anemia before dialysis therapy initiation with erythropoiesis-stimulating agents alters outcomes. STUDY DESIGN: Post hoc analysis of a randomized controlled trial. SETTING & PARTICIPANTS: Participants with type 2 diabetes and chronic kidney disease who progressed to dialysis therapy (n=590) in the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT)...
December 19, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30579709/trends-in-incidence-of-eskd-in-people-with-type-1-and-type-2-diabetes-in-australia-2002-2013
#12
Digsu N Koye, Dianna J Magliano, Christopher M Reid, Meda E Pavkov, Steven J Chadban, Stephen P McDonald, Kevan R Polkinghorne, Sarah White, Christine Paul, Jonathan E Shaw
RATIONALE & OBJECTIVE: The number of people with diabetes and end-stage kidney disease (ESKD) is increasing worldwide, but it is unknown whether this indicates an increasing risk for ESKD in people with diabetes. We examined temporal trends in the incidence of ESKD within the Australian population with diabetes from 2002 to 2013. STUDY DESIGN: Follow-up study using a national health care services registry. SETTING & PARTICIPANTS: Registrants with type 1 or type 2 diabetes in Australia's National Diabetes Services Scheme (NDSS)...
December 14, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30554800/allostasis-and-the-clinical-manifestations-of-mild-to-moderate-chronic-hyponatremia-no-good-adaptation-goes-unpunished
#13
REVIEW
Ignacio Portales-Castillo, Richard H Sterns
When homeostatic regulatory systems are unable to maintain a normal serum sodium concentration, the organism must adapt to demands of a disordered internal environment, a process known as "allostasis." Human cells respond to osmotic stress created by an abnormal serum sodium level with the same adaptations used by invertebrate organisms that do not regulate body fluid osmolality. To avoid intolerable changes in their volume, cells export organic osmolytes when exposed to a low serum sodium concentration and accumulate these intracellular solutes when serum sodium concentration increases...
December 14, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30554801/vegf-a-links-angiolymphoid-hyperplasia-with-eosinophilia-alhe-to-thsd7a-membranous-nephropathy-a-report-of-2-cases
#14
Ayumi Matsumoto, Isao Matsui, Tomoko Namba, Yusuke Sakaguchi, Hitoshi Mizuno, Yuki Shirayama, Karin Shimada, Nobuhiro Hashimoto, Yohei Doi, Satoshi Yamaguchi, Keiichi Kubota, Tatsufumi Oka, Daisuke Mori, Shinichi Akiyama, Takayuki Hamano, Masayuki Mizui, Yoshitsugu Takabatake, Tetsuya Kaneko, Yoshitaka Isaka
Autoantibodies against thrombospondin type 1 domain-containing 7A (THSD7A) cause membranous nephropathy (MN); however, the mechanisms involved in THSD7A expression and immunization are uncertain. We present 2 cases of THSD7A-associated MN accompanied by angiolymphoid hyperplasia with eosinophilia (ALHE), a benign tumor characterized by proliferation of plump endothelial cells. Prednisolone therapy, but not surgical resection of ALHE tumors, successfully suppressed eosinophilia and proteinuria in both cases...
December 13, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30551895/recurrent-acute-kidney-injury-can-we-differentiate-from-nonrecovery-and-ckd-progression
#15
EDITORIAL
Etienne Macedo, Ravindra L Mehta
No abstract text is available yet for this article.
December 12, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30545708/use-of-measures-of-inflammation-and-kidney-function-for-prediction-of-atherosclerotic-vascular-disease-events-and-death-in-patients-with-ckd-findings-from-the-cric-study
#16
Richard L Amdur, Harold I Feldman, Elizabeth A Dominic, Amanda H Anderson, Srinivasan Beddhu, Mahboob Rahman, Myles Wolf, Muredach Reilly, Akinlolu Ojo, Raymond R Townsend, Alan S Go, Jiang He, Dawei Xie, Sally Thompson, Matthew Budoff, Scott Kasner, Paul L Kimmel, John W Kusek, Dominic S Raj
RATIONALE & OBJECTIVE: Traditional risk estimates for atherosclerotic vascular disease (ASVD) and death may not perform optimally in the setting of chronic kidney disease (CKD). We sought to determine whether the addition of measures of inflammation and kidney function to traditional estimation tools improves prediction of these events in a diverse cohort of patients with CKD. STUDY DESIGN: Observational cohort study. SETTING & PARTICIPANTS: 2,399 Chronic Renal Insufficiency Cohort (CRIC) Study participants without a history of cardiovascular disease at study entry...
December 10, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30545707/exploring-barriers-and-potential-solutions-in-home-dialysis-an-nkf-kdoqi-conference-outcomes-report
#17
Christopher T Chan, Eric Wallace, Thomas A Golper, Mitchell H Rosner, Rebecca Kurnik Seshasai, Joel D Glickman, Martin Schreiber, Patrick Gee, Michael V Rocco
Home dialysis therapy, including home hemodialysis and peritoneal dialysis, is underused as a modality for the treatment of chronic kidney failure. The National Kidney Foundation-Kidney Disease Outcomes Quality Initiative sponsored a home dialysis conference in late 2017 that was designed to identify the barriers to starting and maintaining patients on home dialysis therapy. Clinical, operational, policy, and societal barriers were identified that need to be overcome to ensure that dialysis patients have the freedom to choose their treatment modality...
December 10, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30545706/the-donut-or-the-hole-prioritizing-patient-and-caregiver-values-in-the-delivery-of-high-quality-medical-management-without-dialysis
#18
EDITORIAL
Fahad Saeed, Dale Lupu, Alvin H Moss
No abstract text is available yet for this article.
December 10, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30545705/sex-disparities-in-esrd-related-mortality-a-call-to-action
#19
EDITORIAL
Bethany J Foster
No abstract text is available yet for this article.
December 10, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30528935/acute-thrombotic-microangiopathy-and-cortical-necrosis-following-administration-of-alemtuzumab-a-case-report
#20
Ashley A Liou, Brent M Skiver, Eric Yates, Paul Persad, David Meyer, Andrew M Farland, Michael V Rocco
Alemtuzumab, a humanized monoclonal antibody that targets CD52 antigens on lymphocytes and monocytes, has shown efficacy in preventing relapse in relapsing-remitting multiple sclerosis. Despite known severe (yet rare) renal side effects such as anti-glomerular basement membrane disease and membranous glomerulopathy, to our knowledge, alemtuzumab has never been documented to cause drug-induced thrombotic microangiopathy. We describe a 39-year-old woman with relapsing-remitting multiple sclerosis who developed acute kidney injury requiring renal replacement therapy after 1 dose of alemtuzumab, as well as microangiopathic hemolytic anemia and thrombocytopenia...
December 7, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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