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American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation

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https://www.readbyqxmd.com/read/30424916/kidney-function-and-hospital-acquired-infections-worth-a-deeper-look
#1
EDITORIAL
Seth Wright, Shira Doron, Mark J Sarnak
No abstract text is available yet for this article.
November 10, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30424915/estimated-gfr-decline-and-tubular-injury-biomarkers-with-intensive-blood-pressure-control
#2
EDITORIAL
Carl P Walther, Maulin Shah, Sankar D Navaneethan
No abstract text is available yet for this article.
November 10, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30420158/curegn-study-rationale-design-and-methods-establishing-a-large-prospective-observational-study-of-glomerular-disease
#3
Laura H Mariani, Andrew S Bomback, Pietro A Canetta, Michael F Flessner, Margaret Helmuth, Michelle A Hladunewich, Jonathan J Hogan, Krzysztof Kiryluk, Patrick H Nachman, Cynthia C Nast, Michelle N Rheault, Dana V Rizk, Howard Trachtman, Scott E Wenderfer, Corinna Bowers, Peg Hill-Callahan, Maddalena Marasa, Caroline J Poulton, Adelaide Revell, Suzanne Vento, Laura Barisoni, Dan Cattran, Vivette D'Agati, J Charles Jennette, Jon B Klein, Louis-Philippe Laurin, Katherine Twombley, Ronald J Falk, Ali G Gharavi, Brenda W Gillespie, Debbie S Gipson, Larry A Greenbaum, Lawrence B Holzman, Matthias Kretzler, Bruce Robinson, William E Smoyer, Lisa M Guay-Woodford
RATIONALE & OBJECTIVES: Glomerular diseases, including minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and immunoglobulin A (IgA) nephropathy, share clinical presentations, yet result from multiple biological mechanisms. Challenges to identifying underlying mechanisms, biomarkers, and new therapies include the rarity of each diagnosis and slow progression, often requiring decades to measure the effectiveness of interventions to prevent end-stage kidney disease (ESKD) or death...
November 9, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30413277/kidney-transplantation-in-c3-glomerulopathy-a-case-series
#4
Renu Regunathan-Shenk, Rupali S Avasare, Wooin Ahn, Pietro A Canetta, David J Cohen, Gerald B Appel, Andrew S Bomback
RATIONALE & OBJECTIVE: C3 glomerulopathy (C3G), a form of glomerulonephritis associated with dysregulation of the alternative complement pathway, occurs either as dense deposit disease (DDD) or C3 glomerulonephritis (C3GN). Few studies have reported outcomes of patients with C3G after transplantation since its formal classification and the advent of complement-targeting therapies such as eculizumab. STUDY DESIGN: Case series of C3G. SETTING & PARTICIPANTS: We reviewed laboratory testing, native and allograft biopsy reports, and clinical charts of the 19 patients (12, C3GN; and 7, DDD) from our C3G registry who underwent transplantation between 1999 and 2016...
November 6, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30392981/technique-failure-in-a-multicenter-canadian-home-hemodialysis-cohort
#5
Robert P Pauly, Rhonda J Rosychuk, Iram Usman, Frances Reintjes, Maliha Muneer, Christopher T Chan, Michael Copland, Robert Lindsay, Jennifer MacRae, Gihad Nesrallah, Andreas Pierratos, Deborah L Zimmerman, Paul Komenda
RATIONALE & OBJECTIVE: Increasing uptake of home hemodialysis (HD) has led to interest in characteristics that predict discontinuation of home HD therapy for reasons other than death or transplantation. Recent reports of practice pattern variability led to the hypothesis that there are patient- and center-specific factors that influence these discontinuations. STUDY DESIGN: Retrospective cohort study. SETTING & PARTICIPANTS: Incident home HD patients at 7 centers in Canada between 2000 and 2010...
November 1, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30360961/african-american-living-donors-attitudes-about-apol1-genetic-testing-a-mixed-methods-study
#6
Elisa J Gordon, Daniela Amόrtegui, Isaac Blancas, Catherine Wicklund, John Friedewald, Richard R Sharp
RATIONALE & OBJECTIVE: African American live kidney donors ("donors") have a greater risk for kidney failure than European American donors. Apolipoprotein L1 gene (APOL1) variants in African Americans may be associated with this disparity. STUDY DESIGN: Cross-sectional mixed-methods design. SETTING & PARTICIPANTS: African American donors at 1 transplantation center. ANALYTICAL APPROACH: Semistructured interviews assessed attitudes about APOL1 genetic testing, willingness to undergo APOL1 testing, hypothetical decisions about donating with 2 APOL1 variants, and demographics...
October 22, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30348535/relationship-of-estimated-gfr-and-albuminuria-to-concurrent-laboratory-abnormalities-an-individual-participant-data-meta-analysis-in-a-global-consortium
#7
Lesley A Inker, Morgan E Grams, Andrew S Levey, Josef Coresh, Massimo Cirillo, John F Collins, Ron T Gansevoort, Orlando M Gutierrez, Takayuki Hamano, Gunnar H Heine, Shizukiyo Ishikawa, Sun Ha Jee, Florian Kronenberg, Martin J Landray, Katsuyuki Miura, Girish N Nadkarni, Carmen A Peralta, Dietrich Rothenbacher, Elke Schaeffner, Sanaz Sedaghat, Michael G Shlipak, Luxia Zhang, Arjan D van Zuilen, Stein I Hallan, Csaba P Kovesdy, Mark Woodward, Adeera Levin
RATIONALE & OBJECTIVE: Chronic kidney disease (CKD) is complicated by abnormalities that reflect disruption in filtration, tubular, and endocrine functions of the kidney. Our aim was to explore the relationship of specific laboratory result abnormalities and hypertension with the estimated glomerular filtration rate (eGFR) and albuminuria CKD staging framework. STUDY DESIGN: Cross-sectional individual participant-level analyses in a global consortium. SETTING & STUDY POPULATIONS: 17 CKD and 38 general population and high-risk cohorts...
October 19, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30343958/separation
#8
EDITORIAL
Joseph P Gaut
No abstract text is available yet for this article.
October 18, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30343957/intravenous-sodium-bicarbonate-in-treating-patients-with-severe-metabolic-acidemia
#9
EDITORIAL
Jeffrey A Kraut, Nicolaos E Madias
No abstract text is available yet for this article.
October 18, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30343956/arnt-as-a-novel-antifibrotic-target-in-ckd
#10
EDITORIAL
Volker H Haase
No abstract text is available yet for this article.
October 18, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30318133/the-use-of-n-of-1-trials-to-individualize-treatment-in-patients-with-renal-magnesium-wasting
#11
LETTER
Anneke P Bech, Jack F M Wetzels, Hans Groenewoud, Tom Nijenhuis
No abstract text is available yet for this article.
October 11, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30318132/sex-disparities-in-risk-of-mortality-among-children-with-esrd
#12
Patrick Ahearn, Kirsten L Johansen, Charles E McCulloch, Barbara A Grimes, Elaine Ku
RATIONALE & OBJECTIVE: In the general population, girls have lower mortality risk compared with boys. However, few studies have focused on sex differences in survival and in access to kidney transplantation among children with end-stage kidney disease. STUDY DESIGN: Retrospective cohort study. SETTING & PARTICIPANTS: Children aged 2 to 19 years registered in the US Renal Data System who started renal replacement therapy (RRT) between 1995 and 2011...
October 11, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30309714/ckd-due-to-a-novel-mitochondrial-dna-mutation-a-case-report
#13
Fernando C Fervenza, Ralitza H Gavrilova, Samih H Nasr, Maria V Irazabal, Karl A Nath
In human kidney disease, mitochondrial ultrastructural damage has long been recognized. Although the extent to which such mitochondrial changes contribute to human kidney disease is uncertain, experimental studies clearly demonstrate that mitochondrial damage can instigate pathogenetic processes that drive ongoing kidney disease. Clinical credence for this experimentally based hypothesis is provided by the development of kidney disease in patients with primary mitochondrial disorders. In this regard, substantial interest surrounds the occurrence of kidney disease in primary mitochondrial cytopathies, a heterogeneous group of conditions in which mutations in mitochondrial DNA (mtDNA) or nuclear DNA impair the functionality of components of the mitochondrial respiratory chain...
October 8, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30309713/kidneys
#14
EDITORIAL
Sandra Miller
No abstract text is available yet for this article.
October 8, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30297083/urine-acidification-after-ammonium-chloride
#15
LETTER
Anneke P Bech, Tom Nijenhuis, Jack F M Wetzels
No abstract text is available yet for this article.
October 5, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30297082/the-role-of-vitamin-d-in-ckd-stages-3-to-4-report-of-a-scientific-workshop-sponsored-by-the-national-kidney-foundation
#16
Michal L Melamed, Michel Chonchol, Orlando M Gutiérrez, Kamyar Kalantar-Zadeh, Jessica Kendrick, Keith Norris, Julia J Scialla, Ravi Thadhani
Deficiency of 25-hydroxyvitamin D (25[OH]D) is common in patients with chronic kidney disease stages 3 and 4 and is associated with poor outcomes. However, the evaluation and management of vitamin D deficiency in nephrology remains controversial. This article reports on the proceedings from a "controversies conference" on vitamin D in chronic kidney disease that was sponsored by the National Kidney Foundation. The report outlines the deliberations of the 3 work groups that participated in the conference...
October 5, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30293669/psychosocial-health-and-lifestyle-behaviors-in-young-adults-receiving-renal-replacement-therapy-compared-to-the-general-population-findings-from-the-speak-study
#17
Alexander J Hamilton, Fergus J Caskey, Anna Casula, Yoav Ben-Shlomo, Carol D Inward
RATIONALE & OBJECTIVE: Patients in late adolescence and early adulthood receiving renal replacement therapy (RRT) face disruption to normal activities, which affects well-being. We aimed to define psychosocial and lifestyle outcomes for young adults on RRT compared to the general population. STUDY DESIGN: We undertook a cross-sectional survey (the SPEAK [Surveying Patients Experiencing Young Adult Kidney Failure] Study) using validated measures and general population comparator data from the Health Survey for England and Avon Longitudinal Study of Parents and Children...
October 4, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30291012/effects-of-intensive-blood-pressure-lowering-on-kidney-tubule-injury-in-ckd-a-longitudinal-subgroup-analysis-in-sprint
#18
Rakesh Malhotra, Timothy Craven, Walter T Ambrosius, Anthony A Killeen, William E Haley, Alfred K Cheung, Michel Chonchol, Mark Sarnak, Chirag R Parikh, Michael G Shlipak, Joachim H Ix
BACKGROUND: Random assignment to the intensive systolic blood pressure (SBP) arm (<120mmHg) in the Systolic Blood Pressure Intervention Trial (SPRINT) resulted in more rapid declines in estimated glomerular filtration rates (eGFRs) than in the standard arm (SBP<140mmHg). Whether this change reflects hemodynamic effects or accelerated intrinsic kidney damage is unknown. STUDY DESIGN: Longitudinal subgroup analysis of clinical trial participants. SETTINGS & PARTICIPANTS: Random sample of SPRINT participants with prevalent chronic kidney disease (CKD) defined as eGFR<60mL/min/1...
September 28, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30291011/effect-of-intensive-blood-pressure-lowering-on-kidney-tubule-injury-findings-from-the-accord-trial-study-participants
#19
Girish N Nadkarni, Kinsuk Chauhan, Veena Rao, Joachim H Ix, Michael G Shlipak, Chirag R Parikh, Steven G Coca
RATIONALE & OBJECTIVE: Random assignment to intensive blood pressure (BP) lowering (systolic BP<120mmHg) compared to a less intensive BP target (systolic BP<140mmHg) in the Action to Control Cardiovascular Risk in Diabetes BP (ACCORD-BP) trial resulted in a more rapid decline in estimated glomerular filtration rate (eGFR). Whether this reflects hemodynamic effects or intrinsic kidney damage is unknown. STUDY DESIGN: Longitudinal analysis of a subgroup of clinical trial participants...
September 28, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30269868/screening-for-latent-tuberculosis-infection-in-migrants-with-ckd-a-cost-effectiveness-analysis
#20
Jonathon R Campbell, James C Johnston, Lisa A Ronald, Mohsen Sadatsafavi, Robert F Balshaw, Victoria J Cook, Adeera Levin, Fawziah Marra
RATIONALE & OBJECTIVE: In countries with a low tuberculosis (TB) incidence, TB disproportionately affects populations born abroad. TB persists in these populations through reactivation of latent TB infection (LTBI) acquired before immigration. Those with chronic kidney disease (CKD) are at increased risk for reactivation and may benefit from LTBI screening and treatment. STUDY DESIGN: Health administrative data from British Columbia, Canada, were used to inform a cost-effectiveness analysis evaluating LTBI screening in those diagnosed with stage 4 or 5 CKD not requiring dialysis (late-stage CKD) and those who began dialysis therapy...
September 28, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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