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Mayo Clinic Proceedings

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https://www.readbyqxmd.com/read/27916394/hypoactive-sexual-desire-disorder-international-society-for-the-study-of-women-s-sexual-health-isswsh-expert-consensus-panel-review
#1
REVIEW
Irwin Goldstein, Noel N Kim, Anita H Clayton, Leonard R DeRogatis, Annamaria Giraldi, Sharon J Parish, James Pfaus, James A Simon, Sheryl A Kingsberg, Cindy Meston, Stephen M Stahl, Kim Wallen, Roisin Worsley
The objective of the International Society for the Study of Women's Sexual Health expert consensus panel was to develop a concise, clinically relevant, evidence-based review of the epidemiology, physiology, pathogenesis, diagnosis, and treatment of hypoactive sexual desire disorder (HSDD), a sexual dysfunction affecting approximately 10% of adult women. Etiologic factors include conditions or drugs that decrease brain dopamine, melanocortin, oxytocin, and norepinephrine levels and augment brain serotonin, endocannabinoid, prolactin, and opioid levels...
November 30, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27890407/postoperative-tachycardia-clinically-meaningful-or-benign-consequence-of-orthopedic-surgery
#2
Alana E Sigmund, Yixin Fang, Matthew Chin, Harmony R Reynolds, Leora I Horwitz, Ezra Dweck, Eduardo Iturrate
OBJECTIVE: To determine the clinical significance of tachycardia in the postoperative period. PATIENTS AND METHODS: Individuals 18 years or older undergoing hip and knee arthroplasty were included in the study. Two data sets were collected from different time periods: development data set from January 1, 2011, through December 31, 2011, and validation data set from December 1, 2012, through September 1, 2014. We used the development data set to identify the optimal definition of tachycardia with the strongest association with the vascular composite outcome (pulmonary embolism and myocardial necrosis and infarction)...
November 24, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27876316/optimism-during-hospitalization-for-first-acute-myocardial-infarction-and-long-term-mortality-risk-a-prospective-cohort-study
#3
Netanela Weiss-Faratci, Ido Lurie, Yael Benyamini, Gali Cohen, Uri Goldbourt, Yariv Gerber
OBJECTIVE: To assess the association between dispositional optimism, defined as generalized positive expectations about the future, and long-term mortality in young survivors of myocardial infarction (MI). PATIENTS AND METHODS: A subcohort of 664 patients 65 years and younger, drawn from the longitudinal Israel Study of First Acute Myocardial Infarction, completed an adapted Life Orientation Test (LOT) questionnaire during their index hospitalization between February 15, 1992, and February 15, 1993...
November 19, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27876315/cardiorespiratory-fitness-and-incidence-of-major-adverse-cardiovascular-events-in-us-veterans-a-cohort-study
#4
Peter F Kokkinos, Charles Faselis, Jonathan Myers, Puneet Narayan, Xuemei Sui, Jiajia Zhang, Carl J Lavie, Hans Moore, Pamela Karasik, Ross Fletcher
OBJECTIVE: To assess the association between exercise capacity and the risk of major adverse cardiovascular events (MACEs). PATIENTS AND METHODS: A symptom-limited exercise tolerance test was performed to assess exercise capacity in 20,590 US veterans (12,975 blacks and 7615 whites; mean ± SD age, 58.2±11.0 years) from the Veterans Affairs medical centers in Washington, District of Columbia, and Palo Alto, California. None had a history of MACE or evidence of ischemia at the time of or before their exercise tolerance test...
November 19, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27876314/risk-of-jaw-osteonecrosis-after-intravenous-bisphosphonates-in-cancer-patients-and-patients-without-cancer
#5
James S Goodwin, Jie Zhou, Yong-Fang Kuo, Jacques Baillargeon
OBJECTIVE: To compare the risk of jaw osteonecrosis after intravenous (IV) bisphosphonate administered to patients with cancer vs patients without cancer. PATIENTS AND METHODS: We conducted a retrospective cohort study of a 5% national sample of Medicare patients administered IV bisphosphonate from January 1, 2008, through December 31, 2013, for cancer vs noncancer indications. Probable jaw osteonecrosis was estimated with an algorithm including diagnoses, surgical procedures, and imaging studies...
November 19, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27871627/executive-leadership-and-physician-well-being-nine-organizational-strategies-to-promote-engagement-and-reduce-burnout
#6
REVIEW
Tait D Shanafelt, John H Noseworthy
These are challenging times for health care executives. The health care field is experiencing unprecedented changes that threaten the survival of many health care organizations. To successfully navigate these challenges, health care executives need committed and productive physicians working in collaboration with organization leaders. Unfortunately, national studies suggest that at least 50% of US physicians are experiencing professional burnout, indicating that most executives face this challenge with a disillusioned physician workforce...
November 18, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27866655/prediction-of-cardiovascular-mortality-by-estimated-cardiorespiratory-fitness-independent-of-traditional-risk-factors-the-hunt-study
#7
Javaid Nauman, Bjarne M Nes, Carl J Lavie, Andrew S Jackson, Xuemei Sui, Jeff S Coombes, Steven N Blair, Ulrik Wisløff
OBJECTIVE: To assess the predictive value of estimated cardiorespiratory fitness (eCRF) and evaluate the additional contribution of traditional risk factors in cardiovascular disease (CVD) mortality prediction. PARTICIPANTS AND METHODS: The study included healthy men (n=18,721) and women (n=19,759) aged 30 to 74 years. A nonexercise algorithm estimated cardiorespiratory fitness. Cox proportional hazards models evaluated the primary (CVD mortality) and secondary (all-cause, ischemic heart disease, and stroke mortality) end points...
November 16, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27865444/the-prospective-association-of-organized-sports-participation-with-cardiovascular-disease-risk-in-children-the-champs-study-dk
#8
Jeffrey J Hebert, Heidi Klakk, Niels Christian Møller, Anders Grøntved, Lars Bo Andersen, Niels Wedderkopp
OBJECTIVE: To investigate the prospective association of organized leisure-time sports participation with cardiovascular risk in children. METHODS: Students were recruited from 10 public primary schools. From July 2009 to October 2010, parents reported children's weekly organized leisure-time sports participation via text messaging. Clustered cardiovascular risk was estimated with a composite score comprising fasting serum triglyceride levels, homeostasis assessment model-estimated insulin resistance, total to high-density lipoprotein cholesterol ratio, and systolic blood pressure...
November 15, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27855953/increasing-cardiac-rehabilitation-participation-from-20-to-70-a-road-map-from-the-million-hearts-cardiac-rehabilitation-collaborative
#9
REVIEW
Philip A Ades, Steven J Keteyian, Janet S Wright, Larry F Hamm, Karen Lui, Kimberly Newlin, Donald S Shepard, Randal J Thomas
The primary aim of the Million Hearts initiative is to prevent 1 million cardiovascular events over 5 years. Concordant with the Million Hearts' focus on achieving more than 70% performance in the "ABCS" of aspirin for those at risk, blood pressure control, cholesterol management, and smoking cessation, we outline the cardiovascular events that would be prevented and a road map to achieve more than 70% participation in cardiac rehabilitation (CR)/secondary prevention programs by the year 2022. Cardiac rehabilitation is a class Ia recommendation of the American Heart Association and the American College of Cardiology after myocardial infarction or coronary revascularization, promotes the ABCS along with lifestyle counseling and exercise, and is associated with decreased total mortality, cardiac mortality, and rehospitalizations...
November 14, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27842706/insomnia-from-drug-treatments-evidence-from-meta-analyses-of-randomized-trials-and-concordance-with-prescribing-information
#10
Anthony G Doufas, Orestis A Panagiotou, Periklis Panousis, Shane Shucheng Wong, John P A Ioannidis
OBJECTIVE: To determine whether drugs used to treat diverse conditions cause insomnia symptoms and whether their prescription information is concordant with this evidence. METHODS: We conducted a survey of meta-analyses (Cochrane Database of Systematic Reviews) and comparisons with package inserts compiled in the Physicians' Desk Reference (PDR). We identified randomized controlled trials (RCTs) in which any drug had been evaluated vs placebo and sleep had been assessed...
November 11, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27842705/the-language-of-stewardship-is-the-low-value-label-overused
#11
Kevin R Riggs, Sara J Knight
No abstract text is available yet for this article.
November 11, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27842704/61-year-old-woman-with-systemic-lupus-erythematosus-and-chest-pain
#12
Dharma B Sunjaya, Matthew J Koster, Thomas G Osborn
No abstract text is available yet for this article.
November 11, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27836112/depression-after-spinal-surgery-a-comparative-analysis-of-the-california-outcomes-database
#13
Bayard R Wilson, Kathryn R Tringale, Brian R Hirshman, Tianzan Zhou, Anya Umlauf, William R Taylor, Joseph D Ciacci, Bob S Carter, Clark C Chen
OBJECTIVE: To examine the relative incidence of newly recorded diagnosis of depression after spinal surgery as a proxy for the risk of post-spinal surgery depression. PATIENTS AND METHODS: We used the longitudinal California Office of Statewide Health Planning and Development database (January 1, 2000, through December 31, 2010) to identify patients who underwent spinal surgery during these years. Patients with documented depression before surgery were excluded...
November 8, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27836111/empathy-in-the-time-of-burnout
#14
Edward R Melnick, Seth M Powsner
No abstract text is available yet for this article.
November 5, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27825618/the-state-of-the-art-atrial-fibrillation-epidemiology-prevention-and-treatment
#15
REVIEW
Daniel P Morin, Michael L Bernard, Christopher Madias, Paul A Rogers, Sudarone Thihalolipavan, N A Mark Estes
As the most common sustained arrhythmia in adults, atrial fibrillation (AF) is an established and growing epidemic. To provide optimal patient care, it is important for clinicians to be aware of AF's epidemiological trends, methods of risk reduction, and the various available treatment modalities. Our understanding of AF's pathophysiology has advanced, and with this new understanding has come advancements in prevention strategies as well as pharmacological and nonpharmacological treatment options. Following PubMed and MEDLINE searches for AF risk factors, epidemiology, and therapies, we reviewed relevant articles (and bibliographies of those articles) published from 2000 to 2016...
November 5, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27814895/effect-of-center-volume-on-outcomes-in-hospitalized-patients-with-hereditary-hemorrhagic-telangiectasia
#16
Vivek N Iyer, Waleed Brinjikji, Bibek S Pannu, Dinesh R Apala, Giuseppe Lanzino, Harry J Cloft, Sanjay Misra, Michael J Krowka, Christopher P Wood, Karen L Swanson
OBJECTIVE: To determine whether hospitalized patients with hereditary hemorrhagic telangiectasia (HHT) had better outcomes at high-volume treatment centers (HVCs). PATIENTS AND METHODS: The Nationwide Inpatient Sample (2000-2011) was used to identify HHT-related hospitalizations. Hospitals were classified based on quartiles of annual HHT discharge volume. The 75th percentile cutoff value (third quartile) was used to classify hospitals as low-volume centers (1-7 HHT discharges per year) or as HVCs (≥8 discharges per year...
November 1, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27902443/association-between-cataract-and-risk-of-incident-atrial-fibrillation-a-nationwide-population-based-retrospective-cohort-study
#17
Wei-Syun Hu, Cheng-Li Lin
OBJECTIVE: To identify the association between cataract and the subsequent atrial fibrillation (AF) risk. PATIENTS AND METHODS: Our retrospective cohort study was designed to analyze the Longitudinal Health Insurance Database 2000 of the Taiwan National Health Insurance program. We established a cataract cohort (n=39,347) and a noncataract cohort (n=39,347) to observe the incidence of AF. The cataract cohort included patients who were newly diagnosed with cataract from January 1, 2000, to December 31, 2010...
October 27, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27776840/association-of-physical-activity-and-inflammation-with-all-cause-cardiovascular-related-and-cancer-related-mortality
#18
Jong-Young Lee, Seungho Ryu, EunSun Cheong, Ki-Chul Sung
OBJECTIVE: To investigate the association between physical activity (PA) and risk of mortality in a large middle-aged cohort stratified by inflammatory status. PATIENTS AND METHODS: A total of 336,560 individuals (mean age, 39.7 years; 58% male) who underwent comprehensive health screenings were enrolled in this prospective cohort study. They were grouped according to self-reported PA level using a questionnaire: no regular PA with a sedentary lifestyle, regular but insufficient PA (below the guidelines), sufficient PA (concordant with the guidelines), and health-enhancing PA...
October 21, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27810088/the-promise-and-peril-of-precision-medicine-phenotyping-still-matters-most
#19
REVIEW
Jaeger P Ackerman, Daniel C Bartos, Jamie D Kapplinger, David J Tester, Brian P Delisle, Michael J Ackerman
We illustrate the work necessary to reverse course after identification of a KCNQ1 variant interpreted erroneously as causing long QT syndrome (LQTS) and to identify the true cause of a case of sudden death in the young. Surrogate genetic testing of a decedent's living brother identified a rare KCNQ1-V133I variant, which prompted an implantable cardioverter defibrillator and subsequent diagnosis of LQTS in other family members. Subsequently, this presumed LQT1 family came to our institution for further clinical evaluation and research-based investigations, including KCNQ1-V133I variant-specific analysis of the decedent, heterologous expression studies of KCNQ1-V133I, and a whole-exome molecular autopsy along with genomic triangulation using his unaffected parents' DNA...
October 8, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27810087/the-many-faces-of-sudden-death
#20
EDITORIAL
Daniel P Morin, Carl J Lavie
No abstract text is available yet for this article.
October 8, 2016: Mayo Clinic Proceedings
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