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Mayo Clinic Proceedings

Brijesh Patel, George Prousi, Mahek Shah, Paul Secheresiu, Lohit Garg, Manyoo Agarwal, Shantanu Patil, Rahul Gupta, Bruce Feldman
OBJECTIVE: To determine the readmission rate in patients with acute heart failure (AHF) discharged against medical advice (AMA). METHODS: We performed a retrospective analysis using the 2014 National Readmission Database. Patients admitted with a primary diagnosis of AHF were selected. Only those discharged to home and who left AMA were included in the study. The primary outcome was 30-day readmission. We compared the readmission rates among those discharged AMA vs routinely discharged patients using propensity score matching (PSM) to address imbalance in variables between the 2 groups...
July 10, 2018: Mayo Clinic Proceedings
Daniel S Tawfik, Jochen Profit, Timothy I Morgenthaler, Daniel V Satele, Christine A Sinsky, Liselotte N Dyrbye, Michael A Tutty, Colin P West, Tait D Shanafelt
OBJECTIVE: To evaluate physician burnout, well-being, and work unit safety grades in relationship to perceived major medical errors. PARTICIPANTS AND METHODS: From August 28, 2014, to October 6, 2014, we conducted a population-based survey of US physicians in active practice regarding burnout, fatigue, suicidal ideation, work unit safety grade, and recent medical errors. Multivariate logistic regression and mixed-effects hierarchical models evaluated the associations among burnout, well-being measures, work unit safety grades, and medical errors...
July 4, 2018: Mayo Clinic Proceedings
Rafael Fonseca, Desi Peneva, Zoe Clancy, Safiya Abouzaid, Anupam B Jena
No abstract text is available yet for this article.
June 23, 2018: Mayo Clinic Proceedings
Michael D Klajda, Nikhil Kolluri, Nandan S Anavekar
No abstract text is available yet for this article.
June 22, 2018: Mayo Clinic Proceedings
Rachel Wells, Adrian D Elliott, Rajiv Mahajan, Amanda Page, Valeria Iodice, Prashanthan Sanders, Dennis H Lau
OBJECTIVE: To identify the evidence base and evaluate the efficacy of each treatment for postural tachycardia syndrome (POTS) in light of a recent consensus statement highlighting the lack of treatment options with clear benefit to risk ratios for this debilitating condition. METHODS: The CENTRAL (Cochrane Central Register of Controlled Trials), PubMed, and Embase databases from inception to May 2017 were searched using the terms postural AND tachycardia AND syndrome...
June 21, 2018: Mayo Clinic Proceedings
(no author information available yet)
No abstract text is available yet for this article.
June 19, 2018: Mayo Clinic Proceedings
Ayalew Tefferi, Naseema Gangat, Mythri Mudireddy, Terra L Lasho, Christy Finke, Kebede H Begna, Michelle A Elliott, Aref Al-Kali, Mark R Litzow, C Christopher Hook, Alexandra P Wolanskyj, William J Hogan, Mrinal M Patnaik, Animesh Pardanani, Darci L Zblewski, Rong He, David Viswanatha, Curtis A Hanson, Rhett P Ketterling, Jih-Luh Tang, Wen-Chien Chou, Chien-Chin Lin, Cheng-Hong Tsai, Hwei-Fang Tien, Hsin-An Hou
OBJECTIVE: To develop a new risk model for primary myelodysplastic syndromes (MDS) that integrates information on mutations, karyotype, and clinical variables. PATIENTS AND METHODS: Patients with World Health Organization-defined primary MDS seen at Mayo Clinic (MC) from December 28, 1994, through December 19, 2017, constituted the core study group. The National Taiwan University Hospital (NTUH) provided the validation cohort. Model performance, compared with the revised International Prognostic Scoring System, was assessed by Akaike information criterion and area under the curve estimates...
June 1, 2018: Mayo Clinic Proceedings
Aaron S Mansfield, Tobias Peikert, Nicholas J Vogelzang, James T Symanowski
OBJECTIVE: To understand the relationship between response and survival in malignant pleural mesothelioma (MPM). PATIENTS AND METHODS: The original clinical trial was conducted from April 1999 through March 2001. Patients with epithelioid MPM (n=305) were categorized using modified pleural Response Evaluation Criteria in Solid Tumors by whether they responded to treatment. Median progression-free survival (PFS) and overall survival (OS) were estimated and hazard ratios for responders and nonresponders were estimated and compared using the log-rank test...
May 24, 2018: Mayo Clinic Proceedings
Erika L Weil, Lukas W Richards, Bradley R Salonen
No abstract text is available yet for this article.
May 24, 2018: Mayo Clinic Proceedings
Abhishek A Mangaonkar, Mrinal M Patnaik
Short telomere syndromes (STSs) are accelerated aging syndromes often caused by inheritable gene mutations resulting in decreased telomere lengths. Consequently, organ systems with increased cell turnover, such as the skin, bone marrow, lungs, and gastrointestinal tract, are commonly affected. Owing to diverse clinical presentations, STSs pose a diagnostic challenge, with bone marrow failure and idiopathic pulmonary fibrosis being frequent manifestations, occurring in association with gene mutations involving DKC1 (for expansion of gene symbols, use search tool at www...
May 24, 2018: Mayo Clinic Proceedings
S Bradley Hicks, Amrit K Kamboj, Conor G Loftus
No abstract text is available yet for this article.
May 24, 2018: Mayo Clinic Proceedings
Adam R Schmitt, Beverly J Long, Amy L Weaver, Michaela E McGree, Jamie N Bakkum-Gamez, Jerry D Brewer, William A Cliby
OBJECTIVES: To identify the rates of associated and occult cancers in patients with extramammary Paget disease (EMPD) discovered using cancer screening methods at a tertiary medical center; to propose evidence-based cancer screening guidelines at the time of diagnosis of EMPD; and to clarify terminology associating EMPD with underlying malignancies. PATIENTS AND METHODS: A retrospective review of patients with histologically confirmed EMPD presenting for care at our institution between January 1, 1992, and December 31, 2015, was performed...
May 24, 2018: Mayo Clinic Proceedings
Jonah Rubin, Kenneth M Prager
No abstract text is available yet for this article.
May 22, 2018: Mayo Clinic Proceedings
Rhanderson Cardoso, Sanjay Kaul, David R Okada, Roger S Blumenthal, Erin D Michos
No abstract text is available yet for this article.
May 22, 2018: Mayo Clinic Proceedings
Dawit T Zemedikun, Laura J Gray, Kamlesh Khunti, Melanie J Davies, Nafeesa N Dhalwani
OBJECTIVE: To assess the prevalence, disease clusters, and patterns of multimorbidity using a novel 2-stage approach in middle-aged and older adults from the United Kingdom. PATIENTS AND METHODS: Data on 36 chronic conditions from 502,643 participants aged 40 to 69 years with baseline measurements between March 13, 2006, and October 1, 2010, from the UK Biobank were extracted. We combined cluster analysis and association rule mining to assess patterns of multimorbidity overall and by age, sex, and ethnicity...
May 22, 2018: Mayo Clinic Proceedings
José Miguel Rivera-Caravaca, María Asunción Esteve-Pastor, Francisco Marín, Mariano Valdés, Vicente Vicente, Vanessa Roldán, Gregory Y H Lip
OBJECTIVE: To investigate the incidence and risk of adverse clinical outcomes in a "real- world" cohort of patients with atrial fibrillation (AF) anticoagulated with vitamin K antagonists (VKAs) from the Murcia AF Project in comparison with the warfarin arm of the randomized clinical trial (RCT) AMADEUS (Evaluating the Use of SR34006 Compared to Warfarin or Acenocoumarol in Patients With Atrial Fibrillation). PATIENTS AND METHODS: We included 1361 patients with AF from the Murcia AF Project (recruitment from May 1, 2007, to December 1, 2007) and 2293 from the AMADEUS trial (started in September 2003 and primary completed in March 2006), all taking VKA treatment...
May 2, 2018: Mayo Clinic Proceedings
Margaret R Wentz
Recognizing the contribution art has had in the Mayo Clinic environment since the original Mayo Clinic Building was finished in 1914, Mayo Clinic Proceedings features some of the numerous works of art displayed throughout the buildings and grounds on Mayo Clinic campuses as interpreted by the author.
July 2018: Mayo Clinic Proceedings
David P Steensma, Carol A Roede, Robert A Kyle
No abstract text is available yet for this article.
July 2018: Mayo Clinic Proceedings
Lori A Erickson
No abstract text is available yet for this article.
July 2018: Mayo Clinic Proceedings
Sadaf Iftikhar
No abstract text is available yet for this article.
July 2018: Mayo Clinic Proceedings
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