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Mayo Clinic Proceedings

Sargam Kapoor, Jane A Little, Lydia H Pecker
Sickle cell disease (SCD) is a monogenic disorder that afflicts approximately 100,000 Americans and millions of people worldwide. It is characterized by hemolytic anemia, vaso-occlusive crises, relentless end-organ injury, and premature death. Currently, red blood cell transfusion and hydroxyurea are the major disease-modifying therapies available for SCD. Hematopoetic stem cell transplant is curative, but barriers to treatment are substantial and include a lack of suitable donors, immunologic transplant rejection, long-term adverse effects, prognostic uncertainty, and poor end-organ function, which is especially problematic for older patients...
November 7, 2018: Mayo Clinic Proceedings
Christopher V DeSimone, Niyada Naksuk, Samuel J Asirvatham
Supraventricular arrhythmias can cause uncomfortable symptoms for patients. Often, the first point of contact is in the primary care setting, and thus, it is imperative for the general internist to have a clinical framework in place to recognize this cluster of cardiac arrhythmias, be familiar with immediate and long-term management of supraventricular tachycardias, and understand when cardiac electrophysiologic consultation is necessary. The electrocardiographic characteristics can have subtle but important clues to the diagnosis and initial management...
November 7, 2018: Mayo Clinic Proceedings
Kristyn L Lewis, Sheetal Patel, Jose Valery
No abstract text is available yet for this article.
November 7, 2018: Mayo Clinic Proceedings
Jaskanwal D Sara, Megha Prasad, Suraj Kapa
No abstract text is available yet for this article.
November 7, 2018: Mayo Clinic Proceedings
Lindsay S Mayberry, Jonathan S Schildcrout, Kenneth A Wallston, Kathryn Goggins, Amanda S Mixon, Russell L Rothman, Sunil Kripalani
OBJECTIVE: To test theorized patient-level mediators in the causal pathway between health literacy (HL) and 1-year mortality in adults with cardiovascular disease (CVD). PATIENTS AND METHODS: A total of 3000 adults treated at Vanderbilt University Hospital from October 11, 2011, through December 18, 2015, for acute coronary syndrome or acute decompensated heart failure (ADHF) participated in the Vanderbilt Inpatient Cohort Study. Participants completed a bedside-administered survey and consented to health record review and longitudinal follow-up...
November 5, 2018: Mayo Clinic Proceedings
Cheng-Yi Chen, Vin-Cent Wu, Cheng-Jui Lin, Chih-Sheng Lin, Chi-Feng Pan, Han-Hsiang Chen, Yu-Feng Lin, Tao-Min Huang, Likwang Chen, Chih-Jen Wu
OBJECTIVE: To focus on the potential beneficial effects of the pleiotropic effects of dipeptidyl peptidase-4 inhibitors (DPP4is) on attenuating progression of diabetic kidney disease in reducing the long-term effect of the acute kidney injury (AKI) to chronic kidney disease (CKD) transition. PATIENTS AND METHODS: Data from the National Health Insurance Research Database from January 1, 1999, to July 31, 2011, were analyzed, and patients with diabetes weaning from dialysis-requiring AKI were identified...
October 19, 2018: Mayo Clinic Proceedings
Ian J Barbash
No abstract text is available yet for this article.
October 9, 2018: Mayo Clinic Proceedings
Lisa M Daniels, Sarah B Nelson, Ryan D Frank, John G Park
OBJECTIVE: To determine whether treatment of delirium affects outcomes. PATIENTS AND METHODS: A retrospective cohort study of patients admitted to the medical intensive care unit (ICU) from July 1, 2015, through June 30, 2016, was conducted. Patients with ICU delirium, defined by a positive Confusion Assessment Method for the ICU score, were included. Patients were stratified into 4 treatment groups based on exposure to melatonin and antipsychotic agents during ICU stay: no pharmacologic treatment, melatonin only, antipsychotics only, and both melatonin and antipsychotics...
October 3, 2018: Mayo Clinic Proceedings
Phillip J Schulte, David P Martin, Atousa Deljou, Moldovan Sabov, Rosebud O Roberts, David S Knopman, Ronald C Petersen, Toby N Weingarten, Andrew C Hanson, Darrell R Schroeder, David O Warner, Juraj Sprung
OBJECTIVE: To investigate whether older adults with mild cognitive impairment (MCI) or dementia have higher rates of procedures requiring general anesthesia or intensive care unit (ICU) admissions compared with cognitively normal (CN) patients. PATIENTS AND METHODS: A population-based cohort, 70 to 89 years old at enrollment, underwent clinical and longitudinal neurocognitive testing to identify those with MCI and dementia. We analyzed the effects of cognitive status (CN, MCI, or dementia) at entry into the study from October 1, 2004, through December 31, 2014, on the risk of receiving procedures requiring surgical anesthesia and ICU admission...
September 28, 2018: Mayo Clinic Proceedings
Robinson Ramírez-Vélez, José M Saavedra, Felipe Lobelo, Carlos A Celis-Morales, Borja Del Pozo-Cruz, Antonio García-Hermoso
OBJECTIVE: To investigate the association between ideal cardiovascular health (CVH) metrics and incident cardiovascular disease (CVD) by conducting a systematic review and meta-analysis of prospective cohort studies. METHODS: The MEDLINE, EMBASE, and CINAHL databases were searched from January 1, 2010 through July 31, 2017, for studies that met the following criteria: (1) prospective studies conducted in adults, (2) with outcome data on CVD incidence and (3) a measure of ideal CVH metrics...
September 28, 2018: Mayo Clinic Proceedings
Kelly C Gast, Kate Hoversten, Mrinal M Patnaik
No abstract text is available yet for this article.
September 27, 2018: Mayo Clinic Proceedings
Lyanne M Kieneker, Michele F Eisenga, Ron T Gansevoort, Rudolf A de Boer, Gerjan Navis, Robin P F Dullaart, Michel M Joosten, Stephan J L Bakker
The positive relationship between sodium intake and blood pressure is well established. However, results of observational studies on dietary sodium intake and risk of stroke are inconsistent. Moreover, prospective studies with multiple 24-hour urine samples for accurate estimation of habitual sodium intake are scarce. We examined the association of urinary sodium excretion (UNaV) as an accurate estimate of intake with risk of stroke. We studied 7330 individuals free of cardiovascular events at baseline in the Prevention of Renal and Vascular End-stage Disease (PREVEND) study, a prospective, population-based cohort of Dutch men and women...
September 20, 2018: Mayo Clinic Proceedings
Peter Schnohr, James H O'Keefe, Andreas Holtermann, Carl J Lavie, Peter Lange, Gorm Boje Jensen, Jacob Louis Marott
OBJECTIVE: To evaluate the differential improvements in life expectancy associated with participation in various sports. PATIENTS AND METHODS: The Copenhagen City Heart Study (CCHS) is a prospective population study that included detailed questionnaires regarding participation in different types of sports and leisure-time physical activity. The 8577 participants were followed for up to 25 years for all-cause mortality from their examination between October 10, 1991, and September 16, 1994, until March 22, 2017...
September 4, 2018: Mayo Clinic Proceedings
Björn Oskarsson, Tania F Gendron, Nathan P Staff
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting motor neurons and other neuronal cells, leading to severe disability and eventually death from ventilatory failure. It has a prevalence of 5 in 100,000, with an incidence of 1.7 per 100,000, reflecting short average survival. The pathogenesis is incompletely understood, but defects of RNA processing and protein clearance may be fundamental. Repeat expansions in the chromosome 9 open reading frame 72 gene (C9orf72) are the most common known genetic cause of ALS and are seen in approximately 40% of patients with a family history and approximately 10% of those without...
November 2018: Mayo Clinic Proceedings
Margaret R Wentz
Recognizing the contribution art has had in the Mayo Clinic environment since the original Mayo Clinic Building was finished in 1914, Mayo Clinic Proceedings features some of the numerous works of art displayed throughout the buildings and grounds on Mayo Clinic campuses, as interpreted by the author.
November 2018: Mayo Clinic Proceedings
Robert A Kyle, David P Steensma
No abstract text is available yet for this article.
November 2018: Mayo Clinic Proceedings
Linda N Dao, Lori A Erickson
No abstract text is available yet for this article.
November 2018: Mayo Clinic Proceedings
Kenneth N Huynh, Ba D Nguyen
No abstract text is available yet for this article.
November 2018: Mayo Clinic Proceedings
Bhanu Prakash Kolla, Meghna P Mansukhani, Eric J Olson, Erik K St Louis, Michael H Silber, Timothy I Morgenthaler
No abstract text is available yet for this article.
November 2018: Mayo Clinic Proceedings
Eugene L Scharf, Jon O Ebbert, Ryan T Hurt
No abstract text is available yet for this article.
November 2018: Mayo Clinic Proceedings
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