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Mayo Clinic Proceedings

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https://www.readbyqxmd.com/read/29329798/efficacy-of-warfarin-anticoagulation-and-incident-dementia-in-a-community-based-cohort-of-atrial-fibrillation
#1
Malini Madhavan, Tiffany Y Hu, Bernard J Gersh, Veronique L Roger, Jill Killian, Susan A Weston, Jonathan Graff-Radford, Samuel J Asirvatham, Alanna M Chamberlain
OBJECTIVE: To study the association between time in therapeutic range (TTR) during warfarin therapy and risk of dementia in a population-based cohort of incident atrial fibrillation (AF). PATIENTS AND METHODS: We conducted an observational population-based study of 2800 nondemented patients with incident AF from January 1, 2000, through December 31, 2010. The association of incident dementia with warfarin therapy and TTR was examined using Cox proportional hazards regression models...
January 9, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29329797/reducing-risk-of-dementia-in-af-is-oral-anticoagulation-the-key
#2
EDITORIAL
Celine Gallagher, Dennis H Lau, Prashanthan Sanders
No abstract text is available yet for this article.
January 9, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29329796/the-evolving-face-of-myocardial-reperfusion-in-acute-coronary-syndromes-a-primer-for-the-internist
#3
REVIEW
R Jay Widmer, Peter M Pollak, Malcolm R Bell, Bernard J Gersh, Nandan S Anavekar
Acute coronary syndromes (ACSs) account for a large proportion of disease burden in the United States and worldwide, and our understanding of ACS management continues to evolve. In this review we take a practical approach to evaluating and treating a patient with ACS, focusing on the optimal timing and methods of coronary reperfusion. Beginning with initial assessment and risk stratification, a provider managing the patient with ACS must be able to expeditiously decide on and implement the correct guideline-directed pathway to optimize outcomes...
January 9, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29307553/the-role-of-glucagon-in-the-pathophysiology-and-treatment-of-type-2-diabetes
#4
REVIEW
Sofie Hædersdal, Asger Lund, Filip K Knop, Tina Vilsbøll
Type 2 diabetes is a disease involving both inadequate insulin levels and increased glucagon levels. While glucagon and insulin work together to achieve optimal plasma glucose concentrations in healthy individuals, the usual regulatory balance between these 2 critical pancreatic hormones is awry in patients with diabetes. Although clinical discussion often focuses on the role of insulin, glucagon is equally important in understanding type 2 diabetes. Furthermore, an awareness of the role of glucagon is essential to appreciate differences in the mechanisms of action of various classes of glucose-lowering therapies...
January 4, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29307552/aortic-root-dilation-do-patients-with-marfan-syndrome-fare-worse-than-those-with-marfanoid-features
#5
Meghana R K Helder, Hartzell V Schaff, Thomas A Foley, Nandan S Anavekar, David R Deyle, Alberto Pochettino, Heidi M Connolly
OBJECTIVE: To discover whether patients with aortic root dilation and leptosomic features but without a diagnosis of Marfan syndrome (MFS) fare similarly to patients with MFS. METHODS: Of 124 patients with aortic root dilation identified from August 1, 1994, through October 31, 2012, 66 had MFS and 58 had leptosomic features but did not meet the Ghent criteria. Genetic testing was performed in 35% of patients (n=43). We compared z scores and aortic root diameters for patients who presented with aortic root dilation with and without an MFS diagnosis and with and without aortic root repair...
January 4, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29307551/change-in-submaximal-cardiorespiratory-fitness-and-all-cause-mortality
#6
Louise de Lannoy, Xuemei Sui, Carl J Lavie, Steven N Blair, Robert Ross
OBJECTIVE: To evaluate the relationship between change in submaximal cardiorespiratory fitness (sCRF) and all-cause mortality risk in adult men and women. PATIENTS AND METHODS: A prospective study with at least 2 clinical visits (mean follow-up time, 4.2±3.0 years) between April 1974 and January 2002 was conducted to assess the relationship between change in sCRF and mortality risk during follow-up. Participants were 6106 men and women. Submaximal CRF was determined using the heart rate obtained at the 5-minute mark of a graded maximal treadmill test used to determine maximal CRF (mCRF)...
January 4, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29307550/aortic-root-dilation-in-patients-with-leptosomic%C3%A2-features
#7
EDITORIAL
Frank V Brozovich
No abstract text is available yet for this article.
January 4, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29275030/testosterone-and-cardiovascular-health
#8
REVIEW
Andrew Elagizi, Tobias S Köhler, Carl J Lavie
There is an ongoing debate in the medical community regarding the effects of testosterone on cardiovascular (CV) health. For decades, there has been conflicting evidence regarding the association of endogenous testosterone levels and CV disease (CVD) events that has resulted in much debate and confusion among health care providers and patients alike. Testosterone therapy has become increasingly widespread, and after the emergence of studies that reported increased CVD events in patients receiving testosterone therapy, the US Food and Drug Administration (FDA) released a warning statement about testosterone and its potential risk regarding CV health...
December 20, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29275031/the-diagnostic-accuracy-of-fractional-exhaled-nitric-oxide-testing-in-asthma-a-systematic-review-and-meta-analyses
#9
Zhen Wang, Paolo T Pianosi, Karina A Keogh, Feras Zaiem, Mouaz Alsawas, Fares Alahdab, Jehad Almasri, Khaled Mohammed, Laura Larrea-Mantilla, Wigdan Farah, Lubna Daraz, Patricia Barrionuevo, Allison S Morrow, Larry J Prokop, Mohammad Hassan Murad
OBJECTIVE: To evaluate the diagnostic accuracy of fractional exhaled nitric oxide (FeNO) measurement in individuals with suspected asthma. METHODS: We searched MEDLINE, EMBASE, PsycINFO, Cochrane databases, and SciVerse Scopus from the databases' inception through April 4, 2017, for studies that enrolled patients aged 5 years and older with suspected asthma and evaluated FeNO diagnostic accuracy. Independent reviewers selected studies and extracted data. We used the symmetric hierarchical summary receiver operating characteristic models to estimate test performance...
December 16, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29258684/61-year-old-woman-with-episodic-dysphagia-and-chest-pain
#10
Justin G Brandler, Thomas G Cotter, Conor G Loftus
No abstract text is available yet for this article.
December 16, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29258683/79-year-old-woman-with-jaundice-and-anemia
#11
Mazie Tsang, Jayme L Dahlin, Karna K Sundsted
No abstract text is available yet for this article.
December 16, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29258682/23-year-old-man-with-jaundice-and-elevated-liver-enzymes
#12
Jacob Core, Fernando F Stancampiano
No abstract text is available yet for this article.
December 16, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29258681/67-year-old-woman-with-an-adrenal-mass
#13
Jacob Kohlenberg, Irina Bancos
No abstract text is available yet for this article.
December 16, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29223367/relationship-between-obesity-and-survival-in-patients-hospitalized-for-hypertensive-emergency
#14
LETTER
Manyoo A Agarwal, Mahek Shah, Lohit Garg, Carl J Lavie
No abstract text is available yet for this article.
December 6, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29217337/health-literacy-and-outcomes-in-patients-with-heart-failure-a-prospective-community-study
#15
Matteo Fabbri, Kathleen Yost, Lila J Finney Rutten, Sheila M Manemann, Cynthia M Boyd, Daniel Jensen, Susan A Weston, Ruoxiang Jiang, Véronique L Roger
OBJECTIVE: To examine the impact of health literacy on hospitalizations and death in a population of patients with heart failure (HF). PATIENTS AND METHODS: Residents from the 11-county region in southeast Minnesota with a first-ever International Classification of Diseases, Ninth Revision code 428 or Tenth Revision code 150 (n=5121) from January 1, 2013, through December 31, 2015, were identified and prospectively surveyed to measure health literacy using established screening questions...
December 4, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29217336/patient-physician-agreement-using-summary-outcome-determination-scores
#16
Dave R Shukla, Anthony M Vaichinger, Maegan N Shields, Julia Lee, Shabnum Gupta, James S Fitzsimmons, Shawn W O'Driscoll
OBJECTIVE: To determine whether the Summary Outcome Determination (SOD) score had exhibited a high level of physician-patient agreement in surgical patients. PATIENTS AND METHODS: The medical records of 320 postoperative patients were reviewed, of whom 164 patients were included in the study. Patients were included if both physician-assigned and patient-assigned SOD scores had been recorded. The SOD is administered as follows: the patient is asked "Compared to before surgery, is your elbow/shoulder better, worse or no different?" If better: "Is it improved, greatly improved, almost normal or normal?" If worse: "Is it worse or profoundly worse, or as bad as dying?" Each category is associated with a numerical value and definition for further clarification...
December 4, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29217335/rivaroxaban-and-apixaban-for-initial-treatment-of-acute-venous-thromboembolism-of-atypical-location
#17
Dawid T Janczak, Malgorzata K Mimier, Robert D McBane, Patrick S Kamath, Benjamin S Simmons, Dalene M Bott-Kitslaar, Charles J Lenz, Emily R Vargas, David O Hodge, Waldemar E Wysokinski
OBJECTIVES: To assess the outcome of direct oral anticoagulants (DOACs), specifically Xa inhibitors: rivaroxaban and apixaban, for the treatment of venous thromboembolism (VTE) of atypical location (VTE-AL), portal, mesenteric, hepatic, splenic, gonadal, renal, and cerebral veins, prospectively collected data of Mayo Thrombophilia Clinic Registry were used. METHODS: Patients with acute VTE-AL treated with DOACs, enrolled between March 1, 2013, and February 1, 2017, were compared with patients with VTE of typical location (VTE-TL: deep vein thrombosis of extremities and/or pulmonary embolism) receiving DOACs and with patients with VTE-AL treated with enoxaparin...
December 4, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29217334/health-literacy-an-important-clinical-tool-in-heart%C3%A2-failure
#18
EDITORIAL
Hector O Ventura, Ileana L Piña
No abstract text is available yet for this article.
December 4, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29195922/association-between-cardiorespiratory-fitness-and-health-care-costs-the-veterans-exercise-testing-study
#19
Jonathan Myers, Rachelle Doom, Robert King, Holly Fonda, Khin Chan, Peter Kokkinos, David H Rehkopf
OBJECTIVE: To determine the association between cardiorespiratory fitness (CRF) and annual health care costs in Veterans. PATIENTS AND METHODS: The sample included 9942 subjects (mean age, 59±11 years) undergoing a maximal exercise test for clinical reasons between January 2005 and December 2012. Cardiorespiratory fitness, expressed as a percentage of age-predicted peak metabolic equivalents (METs) achieved, was categorized in quartiles. Total and annualized health care costs, derived from the Veterans Administration Allocated Resource Center, were compared using multiple regression, controlling for demographic and clinical characteristics...
November 28, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29174511/cardiorespiratory-fitness-and-health-outcomes-a-call-to-standardize-fitness-categories
#20
Peter Kokkinos, Jonathan Myers, Barry Franklin, Puneet Narayan, Carl J Lavie, Charles Faselis
An inverse association between physical activity or fitness status and health outcomes has been reported by several cohort studies. When fitness categories are established in quartiles or quintiles based on the peak exercise capacity achieved, the association is graded. Although significant health benefits of increased cardiorespiratory fitness (CRF) have been uniformly reported, the degree of protection has varied substantially between studies. This variability is likely due to varying methods used to define CRF categories, and not considering age, despite its strong effect on CRF...
November 22, 2017: Mayo Clinic Proceedings
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