journal
https://read.qxmd.com/read/38529544/incidence-of-symptomatic-venous-thromboembolisms-in-stroke-patients
#1
JOURNAL ARTICLE
Mostafa Al Turk, Michael Abraham
Venous thromboembolism (VTE) is a common but preventable complication observed in critically ill patients. Deep vein thrombosis (DVT) is the most common type of VTE, with clinical significance based on location and symptoms. There is an increased incidence of DVT and pulmonary embolism (PE) in ischemic stroke patients using unfractionated heparin (UFH) for VTE prophylaxis compared with those using enoxaparin. However, UFH is still used in some patients due to its perceived safety, despite conflicting literature suggesting that enoxaparin may have a protective effect...
March 26, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38505947/when-our-best-friend-becomes-our-worst-enemy-the-mitochondrion-in-trauma-surgery-and-critical-illness
#2
REVIEW
May-Kristin Torp, Kåre-Olav Stensløkken, Jarle Vaage
Common for major surgery, multitrauma, sepsis, and critical illness, is a whole-body inflammation. Tissue injury is able to trigger a generalized inflammatory reaction. Cell death causes release of endogenous structures termed damage associated molecular patterns (DAMPs) that initiate a sterile inflammation. Mitochondria are evolutionary endosymbionts originating from bacteria, containing molecular patterns similar to bacteria. These molecular patterns are termed mitochondrial DAMPs (mDAMPs). Mitochondrial debris released into the extracellular space or into the circulation is immunogenic and damaging secondary to activation of the innate immune system...
March 20, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38465637/vascular-reactivity-index-as-an-effective-predictor-of-mortality-in-patients-with-septic-shock-a-retrospective-study
#3
JOURNAL ARTICLE
Sun Jingyi, Gao Cunliang, Chen Biao, Xie Yingguang, Ma Jinluan, Cao Xiaohua, Li Wenqiang
BACKGROUND: Sepsis is a serious complication that occurs after trauma, burns, and infections, and it is an important cause of death in intensive care unit (ICU) patients. Despite many new measures being proposed for sepsis treatment, its mortality rate remains high; sepsis has become a serious threat to human health, and there is an urgent need to carry out in-depth clinical research related to sepsis. In recent years, it has been found that septic shock-induced vasoplegia is a result of vascular hyporesponsiveness to vasopressors...
March 11, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38449336/early-beta-blocker-utilization-in-critically-ill-patients-with-moderate-severe-traumatic-brain-injury-a-retrospective-cohort-study
#4
JOURNAL ARTICLE
Margot Kelly-Hedrick, Sunny Yang Liu, Jordan Komisarow, Jordan Hatfield, Tetsu Ohnuma, Miriam M Treggiari, Katharine Colton, Evangeline Arulraja, Monica S Vavilala, Daniel T Laskowitz, Joseph P Mathew, Adrian Hernandez, Michael L James, Karthik Raghunathan, Vijay Krishnamoorthy
BACKGROUND: There is limited evidence that beta-blockers may provide benefit for patients with moderate-severe traumatic brain injury (TBI) during the acute injury period. Larger studies on utilization patterns and impact on outcomes in clinical practice are lacking. OBJECTIVE: The present study uses a large, national hospital claims-based dataset to examine early beta-blocker utilization patterns and its association with clinical outcomes among critically ill patients with moderate-severe TBI...
March 6, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38415281/nephrotoxic-risk-associated-with-combination-therapy-of-vancomycin-and-piperacillin-tazobactam-in-critically-ill-patients-with-chronic-kidney-disease
#5
JOURNAL ARTICLE
Tamyah Pipkin, Stuart Pope, Alley Killian, Sarah Green, Benjamin Albrecht, Katherine Nugent
Background: The combination of vancomycin and piperacillin-tazobactam (VPT) has been associated with acute kidney injury (AKI) in hospitalized patients when compared to similar combinations. Additional studies examining this nephrotoxic risk in critically ill patients have not consistently demonstrated the aforementioned association. Furthermore, patients with baseline renal dysfunction have been excluded from almost all of these studies, creating a need to examine the risk in this patient population. Methods: This was a retrospective cohort analysis of critically ill adults with baseline chronic kidney disease (CKD) who received vancomycin plus an anti-pseudomonal beta-lactam at Emory University Hospital...
February 28, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38414438/risk-factors-associated-with-intensive-care-admission-in-children-with-severe-acute-respiratory-syndrome-coronavirus-2-related-multisystem-inflammatory-syndrome-mis-c-in-latin-america-a-multicenter-observational-study-of-the-rekamlatina-network
#6
JOURNAL ARTICLE
Jaime Fernández-Sarmiento, Lorena Acevedo, Laura Fernanda Niño-Serna, Raquel Boza, Jimena García-Silva, Adriana Yock-Corrales, Marco A Yamazaki-Nakashimada, Enrique Faugier-Fuentes, Olguita Del Águila, German Camacho-Moreno, Dora Estripeaut, Iván F Gutiérrez, Kathia Luciani, Graciela Espada, Martha I Álvarez-Olmos, Paola Pérez-Camacho, Saulo Duarte-Passos, Maria C Cervi, Edwin M Cantillano, Beatriz A Llamas-Guillén, Patricia Saltigeral-Simental, Javier Criales, Enrique Chacon-Cruz, Miguel García-Domínguez, Karla L Borjas Aguilar, Daniel Jarovsky, Gabriela Ivankovich-Escoto, Adriana H Tremoulet, Rolando Ulloa-Gutierrez
Background: Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 varies widely in its presentation and severity, with low mortality in high-income countries. In this study in 16 Latin American countries, we sought to characterize patients with MIS-C in the pediatric intensive care unit (PICU) compared with those hospitalized on the general wards and analyze the factors associated with severity, outcomes, and treatment received. Study Design: An observational ambispective cohort study was conducted including children 1 month to 18 years old in 84 hospitals from the REKAMLATINA network from January 2020 to June 2022...
February 28, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38414385/updated-review-of-radiologic-imaging-and-intervention-for-acute-pancreatitis-and-its-complications
#7
REVIEW
Joshua Willis, Eric vanSonnenberg
This is a current update on radiologic imaging and intervention of acute pancreatitis and its complications. In this review, we define the various complications of acute pancreatitis, discuss the imaging findings, as well as the timing of when these complications occur. The various classification and scoring systems of acute pancreatitis are summarized. Advantages and disadvantages of the 3 primary radiologic imaging modalities are compared. We then discuss radiologic interventions for acute pancreatitis. These include diagnostic aspiration as well as percutaneous catheter drainage of fluid collections, abscesses, pseudocysts, and necrosis...
February 28, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38414379/epidemiology-and-outcomes-of-critical-illness-and-novel-predictors-of-mortality-in-an-ethiopian-medical-intensive-care-unit
#8
JOURNAL ARTICLE
Aschalew Worku, Deborah Haisch, Madhavi Parekh, Amir Sultan, Abebe Shumet, Kibrom G/Selassie, Max O'Donnell, Amsalu Binegdie, Charles B Sherman, Neil W Schluger
Low- and middle-income countries (LMICs) bear most of the global burden of critical illness. Managing this burden requires improved understanding of epidemiology and outcomes in LMIC intensive care units (ICUs), including LMIC-specific mortality prediction scores. This study was a retrospective observational study at Tikur Anbessa Specialized Hospital in Addis Ababa, Ethiopia, examining all consecutive medical ICU admissions from June 2014 to April 2015. The primary outcome was ICU mortality; secondary outcomes were prolonged ICU stay and prolonged mechanical ventilation...
February 28, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38404127/comparison-of-clinical-characteristics-and-outcomes-in-intensive-care-units-between-patients-with-coronavirus-disease-2019-covid-19-and-patients-with-influenza-a-systematic-review-and-meta-analysis
#9
JOURNAL ARTICLE
Zhuan Zhong, Xin Wang, Jia Guo, Xingzhao Li, Yingying Han
BACKGROUND: Severe infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or influenza virus can cause patients to be admitted to intensive care units (ICUs). It is necessary to understand the differences in clinical characteristics and outcomes between these two types of critically ill patients. METHODS: We searched Embase, PubMed, and Web of Science for articles and performed a meta-analysis using Stata 14.0 with a random-effects model. This paper was written in strict accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
February 25, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38403984/association-of-shock-indices-with-peri-intubation-hypotension-and-other-outcomes-a-sub-study-of-the-keep-pace-trial
#10
JOURNAL ARTICLE
Nathan J Smischney, Mohamed O Seisa, Darrell R Schroeder
BACKGROUND: Based on current evidence, there appears to be an association between peri-intubation hypotension and patient morbidity and mortality. Studies have identified shock indices as possible pre-intubation risk factors for peri-intubation hypotension. Thus, we sought to evaluate the association between shock index (SI), modified shock index (MSI), and diastolic shock index (DSI) and peri-intubation hypotension along with other outcomes. METHODS: The present study is a sub-study of a randomized controlled trial involving critically ill patients undergoing intubation...
February 25, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38403973/study-of-empiric-antibiotic-prescription-patterns-and-microbiological-isolates-in-hemodynamically-stable-and-unstable-icu-patients-with-community-acquired-sepsis
#11
JOURNAL ARTICLE
Mahuya Bhattacharyya, Ananya Saha, Subhash Todi
Background: The efficacy of combination empiric antibiotic therapy for all intensive care unit (ICU) patients with community-acquired sepsis is a subject of ongoing debate in the era of increasing antibiotic resistance. This study was conducted to evaluate the patterns of antibiotic usage and microbial resistance in sepsis patients admitted to the ICU with both hemodynamically stable (HS) and unstable states and to analyze their clinical outcomes. Methods: In this observational study, patients aged 18 years and above who received antibiotics upon admission and had a culture report were included...
February 25, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38403970/comparing-simulation-training-of-bronchoscopy-guided-percutaneous-dilatational-tracheostomy-using-conventional-versus-3d-printed-simulators-trac-sim-study
#12
JOURNAL ARTICLE
Moritz Wegner, Fabian Dusse, Finnard Beeser, Nicolas Leister, Marian Lefarth, Simon-Richard Finke, Bernd W Böttiger, Bernhard Dorweiler, Sandra Emily Stoll
Background: Individual implementation rate of bronchoscopy-guided percutaneous dilatational tracheostomy (PDT) varies among intensivists. Simulation training (ST) can increase the safety of medical procedures by reducing stress levels of the performing team. The aim of this study was to evaluate the benefit of ST in PDT regarding procedural time, quality of performance, and percepted feelings of safety of the proceduralist and to compare conventional simulators (CSIM) with simulators generated from 3D printers (3DSIM)...
February 25, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38374621/the-impact-of-fluid-balance-on-acute-kidney-injury-in-nontraumatic-subarachnoid-hemorrhage
#13
JOURNAL ARTICLE
Dante Merrill, Jack M Craven, Scott Silvey, Daniel Gouger, Chen Wang, Rishi Patel, Vishal Yajnik
Background: Nontraumatic subarachnoid hemorrhage (SAH) can lead to poor neurologic outcomes, particularly when delayed cerebral ischemia (DCI) occurs. Maintenance of euvolemia following SAH is thought to reduce the risk of DCI. However, attempts at maintaining euvolemia often err on the side of hypervolemia. In this study, we assessed the relationship between fluid balance and acute kidney injury (AKI) in SAH patients, assessing hypervolemia versus euvolemia and their impact on AKI. Methods: In a quaternary care center, neuroscience intensive care unit we conducted a retrospective longitudinal analysis in adult patients who suffered a nontraumatic SAH...
February 19, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38374620/prognostic-implications-of-the-timing-of-st-elevation-myocardial-infarction-development-in-relation-to-covid-19-infection
#14
JOURNAL ARTICLE
Aleksandra D Milošević, Marija M Polovina, Dario D Jelic, Damjan D Simic, Mihajlo M Viduljevic, Dragan M Matic, Milenko M Tomic, Tatjana N Adzic, Milika R Asanin
Background: Patients with ST-segment elevation myocardial infarction (STEMI) and COVID-19 infection have a worse clinical course and prognosis. The prognostic significance of the timing of STEMI in relation to COVID-19 infection was not investigated. Objectives: To assess whether the time of STEMI development in relation to COVID-19 infection (concurrent or following the infection) influenced the short-term prognosis. Methods: This was an observational study of consecutive COVID-19 patients with STEMI admitted to the COVID-hospital Batajnica (February 2021-March 2022)...
February 19, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38374617/continuous-versus-intermittent-control-cuff-pressure-for-preventing-ventilator-associated-pneumonia-an-updated-meta-analysis
#15
JOURNAL ARTICLE
Yanshuo Wu, Yanan Li, Meirong Sun, Jingjing Bu, Congcong Zhao, Zhenjie Hu, Yanling Yin
OBJECTIVE: This study aimed to evaluate the effect of continuous control cuff pressure (CCCP) versus intermittent control cuff pressure (ICCP) for the prevention of ventilator-associated pneumonia (VAP) in critically ill patients. METHODS: Relevant literature was searched in several databases, including PubMed, Embase, Web of Science, ProQuest, the Cochrane Library, Wanfang Database and China National Knowledge Infrastructure between inception and September 2022...
February 19, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38374613/ten-influential-point-of-care-ultrasound-papers-2023-in-review
#16
REVIEW
Scott J Millington, Mangala Narasimhan, Paul H Mayo, Antoine Vieillard-Baron
In an effort to help keep busy clinicians up to date with the latest ultrasound research, our group of experts has selected 10 influential papers from the past 12 months and provided a short summary of each. We hope to provide emergency physicians, intensivists, and other acute care providers with a succinct update concerning some key areas of ultrasound interest.
February 19, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38356292/efficacy-and-safety-of-nirmatrelvir-ritonavir-in-severe-hospitalized-patients-with-covid-19-and-in-patients-at-high-risk-for-progression-to-critical-illness-a-real-world-study
#17
JOURNAL ARTICLE
Xiaohua Chen, Ying Zhu, Leer Shen, Dan Zhou, Nannan Feng, Qiang Tong
Background: Nirmatrelvir/Ritonavir is an orally administered anti-SARS-Cov-2 drug used in mild-to-moderate COVID-19 patients. Our retrospective cohort study aims to evaluate the efficacy and safety of Nirmatrelvir/Ritonavir in severe hospitalized patients with Omicron infection, as well as in patients at high risk for progression to critical illness in real-world settings. Methods: A total of 350 patients received Nirmatrelvir/Ritonavir while 350 matched controls did not. Patients with confirmed COVID-19 were administered Nirmatrelvir 300 mg and Ritonavir 100 mg orally twice a day for 5 days, with the medication initiated on the first day after admission...
February 14, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38343031/association-of-body-mass-index-with-multiple-organ-failure-in-hospitalized-patients-with-covid-19-a-multicenter-retrospective-cohort-study
#18
JOURNAL ARTICLE
Timothy Phillips, Abdallah Mughrabi, Levindo J Garcia, Christopher El Mouhayyar, Laith Hattar, Hocine Tighiouart, Andrew H Moraco, Claudia Nader, Bertrand L Jaber
Purpose: This study examines whether excessive adipose tissue, as measured by the body mass index (BMI), is associated with higher systemic markers of inflammation and higher risk of severe acute organ failure among patients with coronavirus disease 2019 (COVID-19). Methods: This was a multicenter retrospective cohort study of 1370 hospitalized adults (18 years or older) with COVID-19 during the first wave of the pandemic. Patient-level variables were extracted from the electronic medical record. The primary predictor variable was the BMI at time of hospital admission, in accordance with the World Health Organization classification...
February 11, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38321761/management-of-immunosuppressive-therapy-in-kidney-transplant-recipients-with-sepsis-a-multicenter-retrospective-study
#19
JOURNAL ARTICLE
Hyung Duk Kim, Byung Ha Chung, Chul Woo Yang, Seok Chan Kim, Kyung Hoon Kim, Shin Young Kim, Kyu Yean Kim, Jongmin Lee
BACKGROUND: Up to 6% of kidney transplant recipients (KTRs) experience life-threatening complications requiring intensive care unit (ICU) admission, and one of the most common medical complications requiring ICU admission is infection. This study aimed to evaluate the effect of immunosuppressive therapy (IST) modification on prognosis of KTRs with sepsis. METHODS: We conducted a multicenter retrospective study in 4 university-affiliated hospitals to evaluate the effect of adjusting the IST in KTRs with sepsis...
February 6, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38320979/clinical-characteristics-outcomes-and-risk-factors-for-mortality-in-pregnant-puerperal-women-with-covid-19-admitted-to-icu-in-turkey-a-multicenter-retrospective-study-from-a-middle-income-country
#20
JOURNAL ARTICLE
Nur Baykara
BACKGROUND: Coronaviruses have been the cause of 3 major outbreaks during the last 2 decades. Information on coronavirus diseases in pregnant women is limited, and even less is known about seriously ill pregnant women. Data are also lacking regarding the real burden of coronavirus disease 2019 (COVID-19) infection in pregnant women from low/middle-income countries. The aim of this study was to determine the characteristics and clinical course of COVID-19 in pregnant/puerperal women admitted to ICUs in Turkey...
February 6, 2024: Journal of Intensive Care Medicine
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