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Vincenzo Venerito, Giuseppe Lopalco, Maria Grazia Anelli, Fabio Cacciapaglia, Florenzo Iannone
No abstract text is available yet for this article.
September 12, 2018: Rheumatology
You-Jung Ha, Yong Seok Choi, Dong Woo Han, Eun Ha Kang, In Seol Yoo, Jin Hyun Kim, Seong Wook Kang, Eun Young Lee, Yeong Wook Song, Yun Jong Lee
Objectives: This study investigated the expression of proviral-integration site for Moloney murine leukaemia virus (PIM) -1 kinase in RA synovium and RA fibroblast-like synoviocytes (FLSs) along with its impact on RA-FLS aggressiveness. Methods: The expression of PIM kinases was assessed in synovial tissues by immunohistochemistry and double IF. After PIM-1 inhibition using either small-interfering RNA or the chemical inhibitor AZD1208, we performed proliferation and migration assays and measured the levels of MMPs and IL-6 released from RA-FLSs under stimulation with proinflammatory cytokines (TNF-α, S100A4 and IL-6/soluble IL-6 receptor)...
September 10, 2018: Rheumatology
Hylton B Menz, Martin J Thomas, Michelle Marshall, Trishna Rathod-Mistry, Alison Hall, Linda S Chesterton, George M Peat, Edward Roddy
Objectives: To examine associations between plantar calcaneal spurs, plantar fascia thickening and plantar heel pain (PHP), and to determine whether tenderness on palpation of the heel differentiates between these presentations. Methods: Adults aged ⩾50 years registered with four general practices were mailed a Health Survey. Responders reporting foot pain within the last 12 months underwent a detailed clinical assessment. PHP in the past month was documented using a foot manikin...
September 10, 2018: Rheumatology
Sayam Dubash, Thiraupathy Marianayagam, Ilaria Tinazzi, Tariq Al-Araimi, Christian Pagnoux, Adam V Weizman, Pascal Richette, My-Linh Tran Minh, Matthieu Allez, Animesh Singh, Francesco Ciccia, John Hamlin, Ai Lyn Tan, Helena Marzo-Ortega, Dennis McGonagle
Objectives: Vedolizumab (VDZ) blocks α4β7 integrin and is licenced for the treatment of IBD. It has been associated with mild SpA-related features, including sacroiliitis and synovitis. Herein we report a series of cases demonstrating the emergence of severe SpA-associated enthesitis/osteitis following successful IBD therapy with VDZ. Methods: We evaluated 11 VDZ-treated patients with IBD across seven centres who developed severe active SpA and/or enthesopathy, with the aim of characterizing the VDZ-associated SpA or entheseal flares...
September 10, 2018: Rheumatology
Yuanyuan Wang, Andrew J Teichtahl, Jean-Pierre Pelletier, François Abram, Anita E Wluka, Sultana Monira Hussain, Johanne Martel-Pelletier, Flavia M Cicuttini
Objective: To examine whether baseline knee joint effusion volume and the change in effusion volume over 1 year are associated with cartilage volume loss, progression of radiographic OA (ROA) over 4 years and risk of total knee replacement over 6 years. Methods: This study included 4115 Osteoarthritis Initiative participants with knee joint effusion volume quantified by MRI at baseline. The change in effusion volume over 1 year was assessed. Cartilage volume loss and progression of ROA over 4 years were assessed using MRI and X-ray and total knee replacement over 6 years was assessed...
September 10, 2018: Rheumatology
Monica S M Persson, Aliya Sarmanova, Michael Doherty, Weiya Zhang
No abstract text is available yet for this article.
September 10, 2018: Rheumatology
Duygu Tecer, Hamit Kucuk
No abstract text is available yet for this article.
September 10, 2018: Rheumatology
Jacqueline S Dekkers, Sytske Anne Bergstra, Arvind Chopra, Mohammed Tikly, João Eurico Fonseca, Karen Salomon-Escoto, Tom W J Huizinga, Diane van der Woude
Objectives: In RA, the relationship between autoantibody status and treatment response to MTX remains unclear. We investigated the association between autoantibody status and early remission in newly diagnosed RA patients treated with MTX using real-world data. Methods: RA-patients initially treated with MTX were selected from an international observational database (METEOR). Patients were stratified into autoantibody-positive (RF- and/or ACPA-positive) or autoantibody negative (RF- and ACPA-negative)...
September 10, 2018: Rheumatology
Haruna Nakaseko, Naomi Iwata, Kazushi Izawa, Hirofumi Shibata, Ryuhei Yasuoka, Toaki Kohagura, Naoki Abe, Shinji Kawabe, Ryuta Nishikomori
No abstract text is available yet for this article.
September 8, 2018: Rheumatology
Domenico Prisco, Elena Silvestri, Gerardo Di Scala, Giacomo Emmi
No abstract text is available yet for this article.
September 8, 2018: Rheumatology
Steven J Russell, Robert Sala, Philip G Conaghan, George Habib, Quang Vo, Rickey Manning, Alan Kivitz, Yvonne Davis, Joelle Lufkin, James R Johnson, Scott Kelley, Neil Bodick
Objective: Approximately 30% of patients with type 2 diabetes mellitus have knee osteoarthritis. IA corticosteroids used to manage osteoarthritis pain can elevate blood glucose in these patients. We compared blood glucose levels following intra-articular injection of triamcinolone acetonide extended-release (TA-ER), an extended-release, microsphere-based triamcinolone acetonide formulation, vs standard triamcinolone acetonide crystalline suspension (TAcs) in patients with knee osteoarthritis and comorbid type 2 diabetes...
September 6, 2018: Rheumatology
Rachel Charlton, Amelia Green, Gavin Shaddick, Julia Snowball, Alison Nightingale, William Tillett, Catherine Smith, Neil McHugh
Objectives: To determine the risk of type 2 diabetes (T2D) and cardiovascular diseases in PsA patients compared with the general population and patients with psoriasis. Methods: Incident PsA patients aged 18-89 years were identified in the UK Clinical Practice Research Datalink between 1998 and 2014 and were matched (1:4 ratio) to a general population cohort and psoriasis cohort. The incidence of T2D, cerebrovascular disease, ischaemic heart disease and peripheral vascular disease (PVD) was calculated for each study cohort...
September 6, 2018: Rheumatology
Chi-Ching Chang, Tzu-Min Lin, Yu-Sheng Chang, Wei-Sheng Chen, Jau-Jiuan Sheu, Yi-Hsuan Chen, Jin-Hua Chen
Objectives: Previous studies have shown myasthenia gravis (MG) and autoimmune rheumatic diseases (ARDs) share common pathogenetic mechanisms. Therefore, the present study investigated the possible relationship between MG and ARDs. Methods: We analysed Taiwanese medical data from the Registry of Catastrophic Illness and identified patients with MG. From the entire general population data of the National Health Insurance Research Database, we randomly selected a comparison cohort that was frequency-matched by age (in 5-year increments), sex, and index date...
September 4, 2018: Rheumatology
Lisa Schapink, Cornelia H M van den Ende, Laura A H A Gevers, Annelies E van Ede, Alfons A den Broeder
Objectives: To investigate the added value of MTX-HCQ combination therapy (CTG) in early RA in a controlled cohort study. MTX monotherapy (MTG) is recommended as (part of) first choice treatment but no head-to-head comparisons are available comparing MTX-HCQ CTG with MTG. Methods: RA patients from the Sint Maartenskliniek and Radboudumc Nijmegen who started MTX with or without concomitant HCQ from April 2010 to October 2015 were included. The primary outcome was the between-group ΔDAS28-CRP at 6 months, and secondary outcomes were ΔDAS28-CRP at 12 months, EULAR response at 6 and 12 months, and treatment intensification...
September 4, 2018: Rheumatology
Kirsten Davies, Marwan Bukhari, Lesley Ottewell
No abstract text is available yet for this article.
August 31, 2018: Rheumatology
Cecilie Heegaard Brahe, Simon Krabbe, Mikkel Østergaard, Lykke Ørnbjerg, Daniel Glinatsi, Henrik Røgind, Hanne S Jensen, Annette Hansen, Jesper Nørregaard, Søren Jacobsen, Lene Terslev, Tuan K Huynh, Dorte V Jensen, Natalia Manilo, Karsten Asmussen, Per Brown Frandsen, Mikael Boesen, Zoreh Rastiemadabadi, Lone Morsel Carlsen, Jakob M Møller, Niels S Krogh, Merete Lund Hetland
Objectives: A cohort of routine care RA patients in sustained remission had biological DMARD (bDMARDs) tapered according to a treatment guideline. We studied: the proportion of patients whose bDMARD could be successfully tapered or discontinued; unwanted consequences of tapering/discontinuation; and potential baseline predictors of successful tapering and discontinuation. Methods: One-hundred-and-forty-three patients (91% receiving TNF inhibitor and 9% a non-TNF inhibitor) with sustained disease activity score (DAS28-CRP)⩽2...
August 28, 2018: Rheumatology
Satoshi Kubo, Yasuyuki Todoroki, Shingo Nakayamada, Kazuhisa Nakano, Minoru Satoh, Aya Nawata, Yurie Satoh, Ippei Miyagawa, Kazuyoshi Saito, Vanessa Smith, Maurizio Cutolo, Yoshiya Tanaka
Objective: The aim of this study was to investigate the clinical and immunological significance of nailfold videocapillaroscopy (NVC) abnormalities in patients with idiopathic inflammatory myopathies (IIMs). Methods: Seventy consecutive Japanese patients with untreated IIMs, enrolled between April 2014 and August 2017, were prospectively studied. Clinical features, NVC findings, autoantibody profile by immunoprecipitation and ELISA, and histopathological findings of skin biopsies of DM rash were assessed at baseline and after 1-year of immunosuppressive therapy...
August 28, 2018: Rheumatology
Aman Sharma, G S R S N K Naidu, Arghya Chattopadhyay, Nupoor Acharya, Saket Jha, Sanjay Jain
No abstract text is available yet for this article.
August 24, 2018: Rheumatology
Lianne Kearsley-Fleet, Michael W Beresford, Rebecca Davies, Diederik De Cock, Eileen Baildam, Helen E Foster, Taunton R Southwood, Wendy Thomson, Kimme L Hyrich
Objectives: To investigate real-world short-term outcomes among patients with systemic JIA starting tocilizumab or anakinra. Methods: This analysis included all systemic JIA patients within the UK Biologics for Children with Rheumatic Diseases study starting tocilizumab or anakinra between 2010 and 2016. Disease activity was assessed at baseline and one year. At one year the following outcomes were assessed: minimal disease activity, clinically inactive disease, 90% ACR Paediatric response (ACRPedi90)...
August 21, 2018: Rheumatology
Christopher R Holroyd, Rakhi Seth, Marwan Bukhari, Anshuman Malaviya, Claire Holmes, Elizabeth Curtis, Christopher Chan, Mohammed A Yusuf, Anna Litwic, Susan Smolen, Joanne Topliffe, Sarah Bennett, Jennifer Humphreys, Muriel Green, Jo Ledingham
This is the executive summary of The British Society for Rheumatology biologic DMARD safety guidelines in inflammatory arthritis, doi: 10.1093/rheumatology/key208.
August 21, 2018: Rheumatology
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