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Rheumatology

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https://www.readbyqxmd.com/read/27864565/targeting-non-canonical-nuclear-factor-%C3%AE%C2%BAb-signalling-attenuates-neovascularization-in-a-novel-3d-model-of-rheumatoid-arthritis-synovial-angiogenesis
#1
Chrissta X Maracle, Paulina Kucharzewska, Boy Helder, Corine van der Horst, Pedro Correa de Sampaio, Ae-Ri Noort, Katinka van Zoest, Arjan W Griffioen, Henric Olsson, Sander W Tas
OBJECTIVE: Angiogenesis is crucial in RA disease progression. Lymphotoxin β receptor (LTβR)-induced activation of the non-canonical nuclear factor-κB (NF-κB) pathway via NF-κB-inducing kinase (NIK) has been implicated in this process. Consequently, inhibition of this pathway may hold therapeutic potential in RA. We describe a novel three-dimensional (3D) model of synovial angiogenesis incorporating endothelial cells (ECs), RA fibroblast-like synoviocytes (RAFLSs) and RA synovial fluid (RASF) to further investigate the contributions of NF-κB in this process...
November 17, 2016: Rheumatology
https://www.readbyqxmd.com/read/27864564/hierarchical-structure-and-importance-of-patients-reasons-for-treatment-choices-in-knee-and-hip-osteoarthritis-a-concept-mapping-study
#2
Ellen M H Selten, Rinie Geenen, Willemijn H van der Laan, Roelien G van der Meulen-Dilling, Henk J Schers, Marc W Nijhof, Cornelia H M van den Ende, Johanna E Vriezekolk
OBJECTIVES: To improve patients' use of conservative treatment options of hip and knee OA, in-depth understanding of reasons underlying patients' treatment choices is required. The current study adopted a concept mapping method to thematically structure and prioritize reasons for treatment choice in knee and hip OA from a patients' perspective. METHODS: Multiple reasons for treatment choices were previously identified using in-depth interviews. In consensus meetings, experts derived 51 representative reasons from the interviews...
November 17, 2016: Rheumatology
https://www.readbyqxmd.com/read/27864563/a-replication-study-and-meta-analysis-of-mitochondrial-dna-variants-in-the-radiographic-progression-of-knee-osteoarthritis
#3
Mercedes Fernández-Moreno, Angel Soto-Hermida, María E Vázquez-Mosquera, Estefanía Cortés-Pereira, Sonia Pértega, Sara Relaño, Natividad Oreiro-Villar, Carlos Fernández-López, Francisco J Blanco, Ignacio Rego-Pérez
OBJECTIVE: To conduct a replication study and meta-analysis involving the study of mtDNA variants in the radiographic progression of OA in different cohorts worldwide, including Cohort Hip and Cohort Knee (CHECK), the OA Initiative and a cohort from Spain. METHODS: The influence of the haplogroups in the rate of radiographic progression at 96 months in 431 subjects from CHECK was assessed in terms of Kellgren and Lawrence (KL) grade. Progression was defined as a change from KL ⩾ 1 at baseline to any higher grade during the follow-up...
November 17, 2016: Rheumatology
https://www.readbyqxmd.com/read/27837049/comment-on-musculoskeletal-complication-of-haematological-malignancy-reply
#4
LETTER
David A Isenberg, Sandra A Morais
No abstract text is available yet for this article.
November 11, 2016: Rheumatology
https://www.readbyqxmd.com/read/27837048/cutaneous-improvement-in-refractory-adult-and-juvenile-dermatomyositis-after-treatment-with-rituximab
#5
Rohit Aggarwal, Priyadarshini Loganathan, Diane Koontz, Zengbiao Qi, Ann M Reed, Chester V Oddis
OBJECTIVE: The aim was to assess the efficacy of rituximab for the cutaneous manifestations of adult DM and JDM. METHODS: Patients with refractory adult DM (n = 72) and JDM (n = 48) were treated with rituximab in a randomized placebo-phase-controlled trial [either rituximab early drug (week 0/1) or rituximab late arms (week 8/9), such that all subjects received study drug]. Stable concomitant therapy was allowed. Cutaneous disease activity was assessed using the Myositis Disease Activity Assessment Tool, which grades cutaneous disease activity on a visual analog scale...
November 11, 2016: Rheumatology
https://www.readbyqxmd.com/read/27837047/comment-on-musculoskeletal-complication-of-haematological-disease
#6
LETTER
Anuoluwapo R Oke, Luke Sammut, Richard G Hull
No abstract text is available yet for this article.
November 11, 2016: Rheumatology
https://www.readbyqxmd.com/read/27818388/acrodermatitis-chronica-atrophicans-probably-an-overlooked-differential-diagnosis-for-arthritis
#7
Morten Kjær, Bente Jensen, Anders Clemmensen
No abstract text is available yet for this article.
November 6, 2016: Rheumatology
https://www.readbyqxmd.com/read/27818387/intravascular-lymphoma-in-a-rheumatoid-arthritis-patient-following-short-term-methotrexate-treatment
#8
LETTER
Takashi Kida, Masataka Kohno, Yoshiaki Chinen, Aiko Tominaga, Takahiro Seno, Taku Tsukamoto, Junya Kuroda, Yutaka Kawahito
No abstract text is available yet for this article.
November 6, 2016: Rheumatology
https://www.readbyqxmd.com/read/27818386/pediatric-necrotizing-myopathy-associated-with-anti-3-hydroxy-3-methylglutaryl-coenzyme-a-reductase-antibodies
#9
Wen-Chen Liang, Akinori Uruha, Shigeaki Suzuki, Nobuyuki Murakami, Eri Takeshita, Wan-Zi Chen, Yuh-Jyh Jong, Yukari Endo, Hirofumi Komaki, Tatsuya Fujii, Yutaka Kawano, Madoka Mori-Yoshimura, Yasushi Oya, Jianying Xi, Wenhua Zhu, Chongbo Zhao, Yurika Watanabe, Keisuke Ikemoto, Atsuko Nishikawa, Kohei Hamanaka, Satomi Mitsuhashi, Norihiro Suzuki, Ichizo Nishino
OBJECTIVE: Antibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) have recently been associated with immune-mediated necrotizing myopathy, especially in patients with statin exposure. As the data are very limited concerning phenotypes and treatment in paediatric patients, we aimed to identify the paediatric patients positive for anti-HMGCR antibodies and clarify their features and therapeutic strategies. METHODS: We screened 62 paediatric patients who were clinically and/or pathologically suspected to have inflammatory myopathy for anti-HMGCR antibodies...
November 6, 2016: Rheumatology
https://www.readbyqxmd.com/read/27815516/systemic-oxalosis-in-hyperoxaluria-type-1
#10
Marília Rodrigues, José Carlos Cardoso, José A P da Silva
No abstract text is available yet for this article.
November 3, 2016: Rheumatology
https://www.readbyqxmd.com/read/27803307/resolution-of-paraneoplastic-pm-scl-positive-systemic-sclerosis-after-curative-resection-of-a-pancreatic-tumour
#11
LETTER
Cosimo Bruni, Ana Lages, Hitesh Patel, Svetlana I Nihtyanova, Bryan Green, Mohammed AbuHilal, Jennifer Harvey, Voon H Ong, Marco Matucci Cerinic, Emma Derrett-Smith, Christopher P Denton
No abstract text is available yet for this article.
November 1, 2016: Rheumatology
https://www.readbyqxmd.com/read/27803306/both-prolonged-remission-and-lupus-low-disease-activity-state-are-associated-with-reduced-damage-accrual-in-systemic-lupus-erythematosus
#12
Michel W P Tsang-A-Sjoe, Irene E M Bultink, Maaike Heslinga, Alexandre E Voskuyl
OBJECTIVES: To identify predictors of organ damage and specifically the relationship between prolonged disease remission or low disease activity and damage accrual in a longitudinal cohort of SLE patients. METHODS: Data were prospectively assessed including the occurrence of minor/major flares. Once a year remission and Lupus Low Disease Activity State (LLDAS) were determined retrospectively. A prediction model for damage accrual during follow-up was constructed with backward logistic regression analyses...
November 1, 2016: Rheumatology
https://www.readbyqxmd.com/read/27803305/clinical-relevance-of-ror%C3%AE-positive-and-negative-subsets-of-cd161-cd4-t-cells-in-primary-sj%C3%A3-gren-s-syndrome
#13
Linlin Zhao, Gaetane Nocturne, Scott Haskett, Saida Boudaoud, Thierry Lazure, Christine Le Pajolec, Xavier Mariette, Michael Mingueneau, Daliya Banerjee
OBJECTIVE: The relevance of the Th17 pathway in primary SS (pSS) is unclear. Published studies have relied on restimulating circulating CD161(+) T cells in vitro for quantitation of IL-17-producing cells. While CD161 marks all IL-17(+) T cells, it is also expressed by other Th subsets. The aim of this study was to directly analyse retinoic acid receptor-related orphan nuclear receptor (ROR)-γ expressing and non-expressing subsets of CD161(+) T cells to determine the relevance of the Th17 pathway in pSS...
November 1, 2016: Rheumatology
https://www.readbyqxmd.com/read/27803304/relationship-of-bone-erosion-with-the-urate-and-soft-tissue-components-of-the-tophus-in-gout-a-dual-energy-computed-tomography-study
#14
Mark Sapsford, Gregory D Gamble, Opetaia Aati, Julie Knight, Anne Horne, Anthony J Doyle, Nicola Dalbeth
OBJECTIVES: Imaging and pathology studies have established a close relationship between tophus and bone erosion in gout. The tophus is an organized structure consisting of urate crystals and chronic inflammatory tissue. The aim of this work was to examine the relationship between bone erosion and each component of the tophus. METHODS: Plain radiographs and dual energy CT scans of the feet were prospectively obtained from 92 people with tophaceous gout. The 10 MTP joints were scored for erosion score, tophus urate and soft tissue volume...
November 1, 2016: Rheumatology
https://www.readbyqxmd.com/read/27794533/the-psoriatic-arthritis-registry-of-turkey-results-of-a-multicentre-registry-on-1081-patients
#15
Umut Kalyoncu, Özün Bayindir, Mustafa Ferhat Öksüz, Atalay Doğru, Gezmiş Kimyon, Emine Figen Tarhan, Abdulsamet Erden, Şule Yavuz, Meryem Can, Gözde Yıldırım Çetin, Levent Kılıç, Orhan Küçükşahin, Ahmet Omma, Cem Ozisler, Dilek Solmaz, Emine Duygu Ersözlü Bozkirli, Lütfi Akyol, Seval Masatlıoğlu Pehlevan, Esen Kasapoglu Gunal, Fatos Arslan, Barış Yılmazer, Nilgun Atakan, Sibel Zehra Aydın
OBJECTIVE: The aim was to assess the characteristics of PsA, find out how well the disease is controlled in real life, demonstrate the treatments and identify the unmet needs. METHODS: The PsA registry of Turkey is a multicentre Web-based registry established in 2014 and including 32 rheumatology centres. Detailed data regarding demographics for skin and joint disease, disease activity assessments and treatment choices were collected. RESULTS: One thousand and eighty-one patients (64...
October 29, 2016: Rheumatology
https://www.readbyqxmd.com/read/27789761/applicability-of-patient-utilities-as-measures-of-overall-quality-of-life-in-rheumatoid-arthritis-clinical-trials
#16
Michael M Ward, Lori C Guthrie
OBJECTIVE: The aim was to determine whether the time trade-off (TTO) and standard gamble utilities can detect treatment-related improvement in overall quality of life in patients with active RA. METHODS: We measured TTO and standard gamble utilities in 192 patients before and after escalation of anti-rheumatic treatment in a prospective longitudinal study. We also examined associations between changes in utilities and patient-reported improvement during the study, and with EULAR responses...
October 27, 2016: Rheumatology
https://www.readbyqxmd.com/read/27789760/the-evidence-for-microbiome-manipulation-in-inflammatory-arthritis
#17
REVIEW
Hannah Jethwa, Sonya Abraham
The human body consists of millions of commensal bacteria (the microbiome), with the intestinal tract being the most prevalent site of colonization. This colonization process begins at birth, and despite numerous factors such as ageing, diet and drug use affecting the microbiome make-up, by adulthood the composition of the gut bacteria is relatively consistent across local populations. The recent advent of new scientific techniques has enabled us to explore how the microbiome affects health and, in particular, has shed light on the involvement of the microbiome in the pathogenesis of inflammatory disease...
October 27, 2016: Rheumatology
https://www.readbyqxmd.com/read/27789759/cryofibrinogenaemia-a-neglected-disease
#18
REVIEW
Sergey Moiseev, Raashid Luqmani, Pavel Novikov, Tatiana Shevtsova
Cryofibrinogen is an abnormal protein that forms precipitate only in plasma. Cryofibrinogenaemia (CF) can be detected both in healthy persons and patients with autoimmune diseases, cancer and infections. Essential CF is frequently asymptomatic, although in a proportion of patients it is associated with skin lesions and systemic manifestations and can lead to refractory skin ulcers and gangrene or thrombotic events. Identification of CF in plasma is simple, but establishing a definite diagnosis may be a challenge due to a lack of accepted diagnostic criteria...
October 27, 2016: Rheumatology
https://www.readbyqxmd.com/read/27744360/chronic-signs-of-memory-b-cell-activation-in-patients-with-beh%C3%A3-et-s-disease-are-partially-restored-by-anti-tumour-necrosis-factor-treatment
#19
Tim B van der Houwen, P Martin van Hagen, Wilhemina M C Timmermans, Sophinus J W Bartol, King H Lam, Jasper H Kappen, Menno C van Zelm, Jan A M van Laar
OBJECTIVES: Behçet's disease (BD), an auto-inflammatory vasculitis with oro-genital ulcerations, skin lesions and uveitis, is regarded as T cell mediated. A successful trial with rituximab suggests an additive role for B cells in the pathogenesis. Therefore, we studied B cell abnormalities in BD patients and the effect of TNF-blocking therapy. METHODS: B cells in blood (n = 36) and tissue (n = 6) of BD patients were analysed with flow cytometry and/or immunohistochemistry and compared with healthy controls (n = 22)...
October 15, 2016: Rheumatology
https://www.readbyqxmd.com/read/27744359/distinguishing-infections-vs-flares-in-patients-with-systemic-lupus-erythematosus
#20
Fabio E Ospina, Alex Echeverri, Diana Zambrano, Juan-Pablo Suso, Javier Martínez-Blanco, Carlos A Cañas, Gabriel J Tobón
SLE is a chronic autoimmune disease involving multiple systems. Patients with SLE are highly susceptible to infections due to the combined effects of their immunosuppressive therapy and the abnormalities of the immune system that the disease itself causes, which can increase mortality in these patients. The differentiation of SLE activity and infection in a febrile patient with SLE is extremely difficult. Activity indexes are useful to identify patients with lupus flares but some clinical and biological abnormalities may, however, make it difficult to differentiate flares from infection...
October 15, 2016: Rheumatology
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