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Stefan T G Bruijnen, Nicki J F Verweij, Leonie M van Duivenvoorden, Nathalie Bravenboer, Dominique L P Baeten, Christiaan J van Denderen, Irene E van der Horst-Bruinsma, Alexandre E Voskuyl, Martijn Custers, Peter M van de Ven, Joost C J Bot, Bouke J H Boden, Adriaan A Lammertsma, Otto S H Hoekstra, Pieter G H M Raijmakers, Conny J van der Laken
Objectives: Excessive bone formation is an important hallmark of AS. Recently it has been demonstrated that axial bony lesions in AS patients can be visualized using 18F-fluoride PET-CT. The aim of this study was to assess whether 18F-fluoride uptake in clinically active AS patients is related to focal bone formation in spine biopsies and is sensitive to change during anti-TNF treatment. Methods: Twelve anti-TNF-naïve AS patients [female 7/12; age 39 years (SD 11); BASDAI 5...
January 9, 2018: Rheumatology
Gaëlle Varkas, Manouk de Hooge, Thomas Renson, Sophie De Mits, Philippe Carron, Peggy Jacques, Muriel Moris, Geert Souverijns, Lennart Jans, Dirk Elewaut, Filip Van den Bosch
No abstract text is available yet for this article.
January 9, 2018: Rheumatology
Roger Hesselstrand, Johanna Nagel, Tore Saxne, Pierra Geborek, Lillemor Skattum, Meliha C Kapetanovic
Objective: To study the impact of disease and treatment with DMARDs on antibody response elicited by either pneumococcal conjugate vaccine (PCV13) or pneumococcal polysaccharide vaccine (PPV23) in patients with SSc. Methods: Forty-four SSc patients and 49 controls received a dose of either PCV13 or PPV23. Twelve patients were treated with DMARDs. Antibody levels to pneumococcal polysaccharides 6B and 23 F were measured before and 4-6 weeks after vaccination using ELISA...
January 8, 2018: Rheumatology
Meghna Jani, William G Dixon, Hector Chinoy
TNF-α inhibitor (TNFi) therapies have transformed the treatment of several rheumatic musculoskeletal diseases. However, the majority of TNFi's are immunogenic and consequent anti-drug antibodies formation can impact on both treatment efficacy and safety. Several controversies exist in the area of immunogenicity of TNFis and drug safety. While anti-drug antibodies to TNFis have been described in association with infusion reactions; serious adverse events (AEs) such as thromboembolic events, lupus-like syndrome, paradoxical AEs, for example, vasculitis-like events and other autoimmune manifestations have also been reported...
January 8, 2018: Rheumatology
Tomohiro Koga, Kiyoshi Migita, Tomohito Sato, Shuntaro Sato, Masataka Umeda, Fumiaki Nonaka, Shoichi Fukui, Shin-Ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Yukitaka Ueki, Junya Masumoto, Kazunaga Agematsu, Akihiro Yachie, Koh-Ichiro Yoshiura, Katsumi Eguchi, Atsushi Kawakami
Objective: We sought to identify the microRNA (miRNA) profile and potential biomarkers in FMF and to clarify their gene targets to elucidate the pathogenesis of FMF. Methods: We performed an miRNA microarray using serum from FMF patients in attack and in remission. We then examined the expression of miRNAs in macrophages derived from THP-1 cells stimulated with toll-like receptor (TLR) ligands. Macrophages derived from THP-1 cells transfected with pre-miRNA were stimulated with lipopolysaccharides (LPSs) for the quantification of inflammatory cytokine production...
December 25, 2017: Rheumatology
John D Pauling, Gloria Salazar, Hui Lu, Zoe E Betteridge, Shervin Assassi, Maureen D Mayes, Neil J McHugh
Objectives: Autoantibodies targeting ubiquitously expressed nuclear antigens can be identified in most patients with SSc. Cytoplasmic autoantibodies (in otherwise ANA-negative sera) targeting eukaryotic initiation factor-2B (anti-eIF2B) have recently been identified in SSc with clinical associations to dcSSc disease and interstitial lung disease (ILD), although the majority of samples originated from a tertiary SSc-ILD centre. We investigated the prevalence and clinical associations of recently described SSc-specific (including anti-eIF2B) and other cytoplasmic autoantibodies in ANA-negative sera obtained from a large representative SSc cohort...
December 22, 2017: Rheumatology
Carlos Augusto Ferreira de Andrade
No abstract text is available yet for this article.
December 22, 2017: Rheumatology
John Henderson, Steven O'Reilly
No abstract text is available yet for this article.
December 21, 2017: Rheumatology
Giuseppina Abignano, Nafisa Fadl, Mira Merashli, Claire Wenham, Jane Freeston, Dennis McGonagle, Helena Marzo-Ortega
No abstract text is available yet for this article.
December 20, 2017: Rheumatology
Fariz Yahya, Karl Gaffney, Louise Hamilton, Ellie Lonsdale, Jane Leeder, Alan Brooksby, Charlotte Cavill, Joshua Berry-Jenkins, Cathal Boyle, Debbie Bond, Raj Sengupta
Objectives: To analyse long-term survival and efficacy of TNFi, reasons for switching or discontinuing, baseline predictors of response and remission in axial spondyloarthritis (axSpA) patients in a UK cohort. Methods: All patients with a physician-verified diagnosis of axSpA attending two specialist centres who fulfilled the eligibility criteria for TNFi were included. Routinely recorded patient data were reviewed retrospectively. Initial TNFi was recorded as the index drug...
December 20, 2017: Rheumatology
Lesley Ann Saketkoo
No abstract text is available yet for this article.
December 20, 2017: Rheumatology
Polina Putrik, Sofia Ramiro, Elisabeth Lie, Kaleb Michaud, Maria K Kvamme, Andras P Keszei, Tore K Kvien, Till Uhlig, Annelies Boonen
Objective: To develop algorithms for calculating the Rheumatic Diseases Comorbidity Index (RDCI), Charlson-Deyo Index (CDI) and Functional Comorbidity Index (FCI) from the Medical Dictionary for Regulatory Activities (MedDRA), and to assess how these MedDRA-derived indices predict clinical outcomes, utility and health resource utilization (HRU). Methods: Two independent researchers linked the preferred terms of the MedDRA classification into the conditions included in the RDCI, the CDI and the FCI...
December 19, 2017: Rheumatology
Zhengping Huang, Changhai Ding, Tianwang Li, Shirley Pei-Chun Yu
OA is a chronic, progressive and disabling joint disease, leading to a poor quality of life and an enormous social and economic burden. Current therapies for OA patients remain limited, which creates an area of huge unmet medical need. For some time, researchers have been looking for approaches that can inhibit the structural progression of OA. A variety of potential disease-modifying OA drugs have been developed, targeting cartilage, inflammatory pathways or subchondral bone. In addition, non-pharmacological therapies, including joint distraction and weight loss, draw increasing attention, with some showing disease-modifying potential...
December 19, 2017: Rheumatology
Stefan Vordenbäumen, Paloma Böhmer, Ralph Brinks, Rebecca Fischer-Betz, Jutta Richter, Ellen Bleck, Petra Rengers, Heike Göhler, Hans-Dieter Zucht, Petra Budde, Peter Schulz-Knappe, Matthias Schneider
Objective: Diagnosis of SLE relies on the detection of autoantibodies. We aimed to assess the diagnostic potential of histone H4 and H2A variant antibodies in SLE. Methods: IgG-autoantibodies to histones H4 (HIST1H4A), H2A type 2-A (HIST2H2AA3) and H2A type 2-C (HIST2H2AC) were measured along with a standard antibody (SA) set including SSA, SSB, Sm, U1-RNP and RPLP2 in a multiplex magnetic microsphere-based assay in 153 SLE patients [85% female, 41 (13.5) years] and 81 healthy controls [77% female, 43...
December 15, 2017: Rheumatology
Leticia A Deveza, Richard F Loeser
OA is a multifaceted and heterogeneous syndrome that may be amenable to tailored treatment. There has been an increasing focus within the OA research community on the identification of meaningful OA phenotypes with potential implications for prognosis and treatment. Experimental and clinical data combined with sophisticated statistical approaches have been used to characterize and define phenotypes from the symptomatic and structural perspectives. An improved understanding of the existing phenotypes based on underlying disease mechanisms may shed light on the distinct entities that make up the disease...
December 15, 2017: Rheumatology
Julien Henry, Jacques-Eric Gottenberg, Stéphanie Rouanet, Stephan Pavy, Jeremie Sellam, Florence Tubach, Rakiba Belkhir, Xavier Mariette, Raphaèle Seror
Objective: To investigate maintenance of rituximab (RTX) in RA patients re-treated with reduced doses compared with standard dose in a real life setting. Methods: The Autoimmunity and Rituximab (AIR) registry is a nationwide prospective observational cohort investigating the long-term safety and efficacy of RTX in RA. The present study included patients from the AIR registry that have been re-treated with RTX after a first course of RTX standard dose (1000 mg × 2)...
December 15, 2017: Rheumatology
Kai Fu, Sarah R Robbins, Jason J McDougall
OA is a painful joint disease that predominantly affects the elderly. Pain is the primary symptom of OA, and it can present as either intermittent or constant. OA pain mechanisms are complex and have only recently been determined. Both peripheral and central processes are involved in creating the OA pain experience, making targeted therapy problematic. Nociceptive, inflammatory and neuropathic pains are all known to occur in OA, but to varying degrees in a patient- and time-specific manner. A better understanding of these multifactorial components of OA pain will lead to the development of more effective and safer pain treatments...
December 15, 2017: Rheumatology
Gaëlle Varkas, Manouk de Hooge, Thomas Renson, Sophie De Mits, Philippe Carron, Peggy Jacques, Muriel Moris, Geert Souverijns, Lennart Jans, Dirk Elewaut, Filip Van den Bosch
Objective: To assess the baseline condition of the SI joints (SIJs) in healthy individuals without symptoms of back pain and to study the effect of mechanical stress caused by intense physical training on MRI of the SIJs. Methods: Twenty-two military recruits underwent an MRI of the SIJs before and after 6 weeks of intense standardized physical training. Bone marrow oedema and structural lesions were scored based on the Spondyloarthritis Research Consortium of Canada (SPARCC) method, by three trained readers blinded for time sequence and clinical findings...
December 14, 2017: Rheumatology
Satoshi Kubo, Shingo Nakayamada, Jidong Zhao, Maiko Yoshikawa, Yusuke Miyazaki, Aya Nawata, Shintaro Hirata, Kazuhisa Nakano, Kazuyoshi Saito, Yoshiya Tanaka
Objective: To assess the role of an abnormal immune network in the pathology of IgG4-related disease (IgG4-RD). Methods: Sixteen patients diagnosed with IgG4-RD at our institution were selected. Peripheral immunocompetent cells were immunophenotyped by multicolour flow cytometry to assess the association between clinical manifestation and pathological findings. Results: Compared with healthy controls, IgG4-RD patients showed comparable proportions of Th1 and Th17 cells, but higher proportions of Treg and follicular helper T (Tfh) cells...
December 14, 2017: Rheumatology
Féline P B Kroon, Wendy Damman, Rani Liu, Jessica Bijsterbosch, Ingrid Meulenbelt, Désirée van der Heijde, Margreet Kloppenburg
Objectives: To investigate metric properties of four hand mobility tests in hand OA patients, using the OMERACT filter. Methods: Trained assessors examined the Hand Mobility in Scleroderma test (HAMIS), fingertip-to-palm distance (FPD), modified Kapandji index (MKI) and number of hand joints with limited mobility in participants from two cohorts [Genetics ARthrosis and Progression (n = 207) and Hand OSTeoArthritis in Secondary care (n = 174)]. Validity was appraised by assessment of correlations with other outcome measures, and ability to measure thumb vs finger mobility specifically, using cumulative probability plots...
December 14, 2017: Rheumatology
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