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Rheumatology

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https://www.readbyqxmd.com/read/29149321/biosimilars-forum-applauds-food-and-drug-administration-on-new-educational-program-promoting-safety-and-effectiveness-of-biosimilars
#1
(no author information available yet)
No abstract text is available yet for this article.
November 14, 2017: Rheumatology
https://www.readbyqxmd.com/read/29149307/tumour-tif1-mutations-and-loss-of-heterozygosity-related-to-cancer-associated-myositis
#2
Iago Pinal-Fernandez, Berta Ferrer-Fabregas, Ernesto Trallero-Araguas, Eva Balada, Maria Angeles Martínez, Jose César Milisenda, Gloria Aparicio-Español, Moises Labrador-Horrillo, Vicente Garcia-Patos, Josep M Grau-Junyent, Albert Selva-O'Callaghan
Objectives: To analyse the influence of genetic alterations and differential expression of transcription intermediary factor 1 ( TIF1 ) genes in the pathophysiology of cancer-associated myositis (CAM). Methods: Paired blood and tumour DNA samples from patients with anti-TIF1γ-positive CAM and from controls were analysed by whole-exome sequencing for the presence of somatic mutations and loss of heterozygosity (LOH) in their TIF1 genes. The genesis and maintenance of the autoimmune process were investigated immunohistochemically by studying TIF1γ expression in the different tissues involved in CAM (skin, muscle and tumour) based on the immunohistochemical H-score...
November 14, 2017: Rheumatology
https://www.readbyqxmd.com/read/29149289/rheumatoid-arthritis-patients-treated-in-trial-and-real-world-settings-comparison-of-randomized-trials-with-registries
#3
Gablu Kilcher, Noemi Hummel, Eva M Didden, Matthias Egger, Stephan Reichenbach
Objective: To investigate whether patients with RA enrolled in randomized controlled trials (RCTs) and observational studies may differ in terms of characteristics that could modify treatment effects, leading to an efficacy-effectiveness gap. Methods: We conducted systematic literature reviews to identify RCTs and observational studies with RA, treated with rituximab, tocilizumab or etanercept. We extracted baseline characteristics and compared the data of RCTs and observational studies using fixed-effects meta-analyses for the RCTs and random-effects meta-analyses for the observational studies...
November 14, 2017: Rheumatology
https://www.readbyqxmd.com/read/29140474/identification-of-novel-systemic-sclerosis-biomarkers-employing-aptamer-proteomic-analysis
#4
Peter J Wermuth, Sonsoles Piera-Velazquez, Sergio A Jimenez
There is an important unmet need for clinically validated non-invasive biomarkers for SSc diagnosis, assessment of disease activity, extent of internal organ involvement, therapeutic response and prognosis. There is also an unmet need for biomarkers to accurately differentiate primary RP from recent onset RP evolving into SSc. The lack of sensitive and specific biomarkers for SSc and SSc-associated RP is a limitation for the optimal clinical management of these patients. The development of highly sensitive and specific proteomic analysis employing aptamers and the expansion in the number of proteins that can be specifically identified by aptamer proteomics have opened new horizons for biomarker discovery...
November 13, 2017: Rheumatology
https://www.readbyqxmd.com/read/29121273/unchanging-premature-mortality-trends-in-systemic-lupus-erythematosus-a-general-population-based-study-1999-2014
#5
April M Jorge, Na Lu, Yuqing Zhang, Sharan K Rai, Hyon K Choi
Objective: Patients with SLE have increased morbidity and premature mortality. Whether this mortality gap has improved in recent years, as in RA, is unknown. Methods: We conducted a population-based cohort study using a medical records database representative of the general population of the UK. We identified incident SLE cases and matched non-SLE controls between 1999 and 2014, divided into two subgroups based on year of SLE diagnosis, forming the early cohort (1999-2006) and late cohort (2007-14)...
November 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/29121263/high-prevalence-of-diabetes-in-patients-with-rheumatoid-arthritis-results-from-a-questionnaire-survey-linked-to-claims-data
#6
Katinka Albrecht, Andres Luque Ramos, Falk Hoffmann, Imke Redeker, Angela Zink
Objectives: To investigate the prevalence of diabetes in patients with RA and the impact of diabetes on self-reported outcomes and health care. Methods: RA patients between the ages of 18 and 79 years were randomly selected from a nationwide statutory health insurance fund and were surveyed about rheumatological care and disease burden. Comorbid diabetes (E10-14) was analysed regarding age, sex, BMI and socioeconomic status. Disease burden, comorbidity and prescriptions were compared in RA patients with and without diabetes...
November 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/29121248/fusion-of-positron-emission-tomography-computed-tomography-with-magnetic-resonance-imaging-reveals-hamstring-peritendonitis-in-polymyalgia-rheumatica
#7
Claire E Owen, Aurora M T Poon, Sze Ting Lee, Lee Pheng Yap, Richard B Zwar, Christine M McMenamin, Simon K L Lam, David F L Liew, Kunthi Pathmaraj, Andrew Kemp, Andrew M Scott, Russell R C Buchanan
Objectives: To characterize 18F-fluorodeoxyglucose (18F-FDG) uptake on whole-body PET/CT in PMR, and identify its precise anatomic correlate using MRI. Methods: Patients with newly diagnosed PMR according to the 2012 EULAR/ACR classification criteria were prospectively recruited. Participants with GCA were excluded. A whole-body 18F-FDG PET/CT scan was performed in all untreated patients. Qualitative and semiquantitative [standardized uptake value maximum (SUVmax)] scoring of abnormal 18F-FDG uptake was undertaken...
November 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/29126313/comment-on-kidney-disease-in-primary-antiphospholipid-antibody-syndrome
#8
Cengiz Korkmaz, Döndü U Cansu
No abstract text is available yet for this article.
November 6, 2017: Rheumatology
https://www.readbyqxmd.com/read/29126279/comment-on-residual-disease-activity-in-psoriatic-arthritis-discordance-between-the-rheumatologist-s-opinion-and-minimal-disease-activity-measurement
#9
https://www.readbyqxmd.com/read/29126262/relapsing-polychondritis-a-clinical-review-for-rheumatologists
#10
Jack Kingdon, Joseph Roscamp, Shirish Sangle, David D'Cruz
Relapsing polychondritis (RPC) is a rare autoimmune rheumatic disorder that is traditionally classified as a systemic vasculitis. It is characterized by inflammation of cartilage, and typical presenting features include chondritis of the nasal bridge, auricular chondritis, ocular inflammation and involvement of the bronchial tree. Its rarity often leads to considerable delay in establishing a diagnosis and poses a significant management challenge to clinicians, as no conventional guidelines exist. This review summarizes the clinical features of RPC and provides guidance for rheumatologists on making the diagnosis and assessing organ involvement...
November 6, 2017: Rheumatology
https://www.readbyqxmd.com/read/29112740/evaluation-of-damage-in-giant-cell-arteritis
#11
Tanaz A Kermani, Antoine G Sreih, David Cuthbertson, Simon Carette, Gary S Hoffman, Nader A Khalidi, Curry L Koening, Carol A Langford, Carol A McAlear, Paul A Monach, Larry Moreland, Christian Pagnoux, Philip Seo, Kenneth J Warrington, Steven R Ytterberg, Peter A Merkel
Objectives: To evaluate damage and variables associated with damage in GCA. Methods: Patients with GCA enrolled in a prospective, multicentre, longitudinal study were included. Per-protocol assessments were made with the Vasculitis Damage Index and the Large-Vessel Vasculitis Index of Damage. Results: The study included 204 patients: 156 women (76%), mean age at diagnosis 71.3 years (s.d. 8.3), mean follow-up of 3.5 years (s.d. 1.9). One or more damage item was present in 54% at baseline and 79% at the last follow-up on the Vasculitis Damage Index, and 60% at baseline and 82% at the last follow-up on the Large-Vessel Vasculitis Index of Damage...
November 3, 2017: Rheumatology
https://www.readbyqxmd.com/read/29112759/epigenetics-and-complex-diseases-a-new-era-in-the-assessment-of-exposure-and-risk
#12
Olga Sánchez-Pernaute, Antonio Gabucio
No abstract text is available yet for this article.
November 2, 2017: Rheumatology
https://www.readbyqxmd.com/read/29112741/atherosclerosis-as-a-potential-pitfall-in-the-diagnosis-of-giant-cell-arteritis
#13
Eugenio De Miguel, Luis M Beltran, Irene Monjo, Francesco Deodati, Wolfgang A Schmidt, Juan Garcia-Puig
Objectives: To explore whether the increase in the intima-media thickness (IMT) in arteriosclerotic disease correlates with the increase in the IMT in temporal arteries (TAs) and if that could mimic the US GCA halo sign. Methods: Consecutive patients ⩾50 years old with high vascular risk and without signs or symptoms of GCA were included. The carotid US IMT measurements were obtained using a standardized software radiofrequency-tracking technology. Colour Doppler US and grey-scale measurements of the IMT in the branches of both TAs were performed by a second sonographer using a 22 MHz probe...
November 2, 2017: Rheumatology
https://www.readbyqxmd.com/read/29095992/radiographic-joint-damage-in-early-rheumatoid-arthritis-patients-comparing-tocilizumab-and-methotrexate-based-treat-to-target-strategies
#14
Xavier M Teitsma, Johannes W G Jacobs, Paco M J Welsing, Attila Pethö-Schramm, Michelle E A Borm, Jacob M van Laar, Floris P J G Lafeber, Johannes W J Bijlsma
Objective: To evaluate the progression of erosions and joint space narrowing (JSN) in feet and hands in the U-Act-Early trial. Methods: In this trial, 317 newly diagnosed DMARD-naïve RA patients initiated randomly tocilizumab, or step-up MTX or a combination of the two. Radiographs were scored at baseline and after 52 and 104 weeks using the Sharp-van der Heijde erosion and JSN score. Between the strategy arms, changes from baseline and the proportions of patients without radiographic progression (change from baseline ≤0) were compared...
October 31, 2017: Rheumatology
https://www.readbyqxmd.com/read/29095989/erratum-to-178-does-physical-activity-change-following-hip-and-knee-replacement-an-analysis-of-data-from-the-osteoarthritis-initiative
#15
(no author information available yet)
No abstract text is available yet for this article.
October 31, 2017: Rheumatology
https://www.readbyqxmd.com/read/29087507/the-revised-bristol-rheumatoid-arthritis-fatigue-measures-and-the-rheumatoid-arthritis-impact-of-disease-scale-validation-in-six-countries
#16
Sarah Hewlett, John Kirwan, Christina Bode, Fiona Cramp, Loreto Carmona, Emma Dures, Matthias Englbrecht, Jaap Fransen, Rosemary Greenwood, Sofia Hagel, Maart van de Laar, Anna Molto, Joanna Nicklin, Ingemar F Petersson, Marta Redondo, Georg Schett, Laure Gossec
Objective: To evaluate the Bristol Rheumatoid Arthritis Fatigue Multidimensional Questionnaire (BRAF-MDQ), the revised Bristol Rheumatoid Arthritis Numerical Rating Scales (BRAF-NRS V2) and the Rheumatoid Arthritis Impact of Disease (RAID) scale in six countries. Methods: We surveyed RA patients in France, Germany, The Netherlands, Spain, Sweden and the UK, including the HAQ, 36-item Short Form Health Survey (SF-36) and potential revisions of the BRAF-NRS coping and Spanish RAID coping items...
October 26, 2017: Rheumatology
https://www.readbyqxmd.com/read/29077976/do-encourage-your-scleroderma-patients-at-risk-to-get-influenza-vaccine
#17
Meliha C Kapetanovic
No abstract text is available yet for this article.
October 25, 2017: Rheumatology
https://www.readbyqxmd.com/read/29077975/spina-ventosa-an-uncommon-case-report-of-primary-tuberculosis-infection
#18
Sonia Rekik, Lobna Ben Ammar, Boussaid Soumaya, Alia Zehani, Héla Sahli, Ilhem Cheour, Mohamed Elleuch, Mohamed Ben Amor
No abstract text is available yet for this article.
October 25, 2017: Rheumatology
https://www.readbyqxmd.com/read/29077973/prevalence-and-predictors-of-tumour-necrosis-factor-inhibitor-persistence-in-psoriatic-arthritis
#19
Carmel Stober, Weiyu Ye, Thushyanthan Guruparan, Eiphyu Htut, Gavin Clunie, Deepak Jadon
Objectives: To evaluate TNF-α inhibitor (TNFi) persistence when used as first- or second-line biologic therapy for the management of PsA, and to determine baseline clinical and laboratory parameters associated with TNFi persistence. Methods: A retrospective single-centre cohort study was performed on all patients with PsA initiated on TNFi therapy between 2003 and 2015. Demographic, clinical and laboratory characteristics were compared with TNFi persistence, using Kaplan-Meier survival and Cox proportional hazards models...
October 25, 2017: Rheumatology
https://www.readbyqxmd.com/read/29077971/tocilizumab-as-a-potential-therapeutic-option-for-children-with-severe-refractory-juvenile-localized-scleroderma
#20
Hanna Lythgoe, Eileen Baildam, Michael W Beresford, Gavin Cleary, Liza J McCann, Clare E Pain
No abstract text is available yet for this article.
October 25, 2017: Rheumatology
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