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Rheumatology

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https://www.readbyqxmd.com/read/28666383/how-routine-use-of-a-treat-to-target-approach-in-psa-might-impact-on-clinical-decision-making
#1
Laura C Coates
No abstract text is available yet for this article.
June 29, 2017: Rheumatology
https://www.readbyqxmd.com/read/28666379/risks-of-serious-infections-in-children-treated-with-biologic-response-modifying-drugs-bacterial-infection-risk-in-children-with-juvenile-idiopathic-arthritis
#2
https://www.readbyqxmd.com/read/28651377/can-epidemiological-studies-uncover-the-origin-of-beh%C3%A3-et-s-disease-the-origin-of-beh%C3%A3-et-s-disease
#3
Jan A M van Laar
No abstract text is available yet for this article.
June 25, 2017: Rheumatology
https://www.readbyqxmd.com/read/28859331/rivaroxaban-versus-warfarin-to-treat-patients-with-thrombotic-antiphospholipid-syndrome-dr-hannah-cohen-about-the-results-of-the-raps-trial-lancet-haematol-2016-3-e426-36
#4
(no author information available yet)
No abstract text is available yet for this article.
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28859330/ultrasound-cut-off-values-for-intima-media-thickness-of-temporal-facial-and-axillary-arteries-in-giant-cell-arteritis
#5
Valentin S Schäfer, Aaron Juche, Sofia Ramiro, Andreas Krause, Wolfgang A Schmidt
No abstract text is available yet for this article.
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28859329/familial-mediterranean-fever-in-children-and-adolescents-factors-for-colchicine-dosage-and-predicting-parameters-for-dose-increase
#6
Anne-Marie Knieper, Jens Klotsche, Elke Lainka, Thomas Berger, Frank Dressler, Annette F Jansson, Christoph Rietschel, Prasad T Oommen, Rainer Berendes, Tim Niehues, Ulrich Neudorf, Dirk Foell, Helmut Wittkowski, Tilmann Kallinich
Objectives: The aim was to analyse factors influencing the individual colchicine dose in children with FMF, to evaluate the impact of dose adjustment on the clinical course and inflammation and to identify clinical parameters and biomarkers that predict dose increase in the near future. Methods: Data from 409 paediatric FMF patients (4566 visits) derived from the national auto-inflammatory diseases registry were analysed. Serum concentrations of S100 molecules were determined by ELISA...
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28859328/are-interferon-related-biomarkers-advantageous-for-monitoring-disease-activity-in-systemic-lupus-erythematosus-a-longitudinal-benchmark-study
#7
Thomas Rose, Andreas Grützkau, Jens Klotsche, Philipp Enghard, Alexandra Flechsig, Johannes Keller, Gabriela Riemekasten, Andreas Radbruch, Gerd-Rüdiger Burmester, Thomas Dörner, Falk Hiepe, Robert Biesen
Objective: To determine the clinical value of six traditional and three IFN-related biomarkers in monitoring disease activity (DA) in SLE. Methods: Prospective longitudinal study of IFNα, IFNγ-inducible protein 10 (IP-10) and sialic acid-binding Ig-like lectin 1 (SIGLEC1) vs antibodies against dsDNA (ELISA and Farr radioimmunoassay), dsDNA-complexed nucleosomes (anti-dsDNA-NcX: ELISA), nucleosomes (ANuA: ELISA) and complement C3/C4 for correlation with DA (measured by BILAG 2004 index) in 26 SLE patients (77 visits)...
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28859327/female-hormonal-factors-and-the-development-of-anti-citrullinated-protein-antibodies-in-women-at-risk-of-rheumatoid-arthritis
#8
Deshiré Alpizar-Rodriguez, Rüdiger B Mueller, Burkhard Möller, Jean Dudler, Adrian Ciurea, Pascal Zufferey, Diego Kyburz, Ulrich A Walker, Ines von Mühlenen, Pascale Roux-Lombard, Michael Mahler, Celine Lamacchia, Delphine S Courvoisier, Cem Gabay, Axel Finckh
Objectives: To analyse the association between female hormonal factors and the development of systemic autoimmunity associated with RA in women at increased risk for RA, namely first-degree relatives of patients with RA (RA-FDRs). Methods: In an ongoing cohort study of RA-FDRs, we analysed all women with available ACPA status. The primary outcome was ACPA positivity. The predictors of interest were female hormonal factors, such as oral contraceptives, breastfeeding, post-menopausal status, early post-menopausal period and total number of ovulatory years...
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28859326/similar-efficacy-and-safety-of-initial-cobra-light-and-cobra-therapy-in-rheumatoid-arthritis-4-year-results-from-the-cobra-light-trial
#9
Nicole P C Konijn, Lilian H D van Tuyl, Maarten Boers, Debby den Uyl, Marieke M Ter Wee, Lindsey K M van der Wijden, Irene E M Bultink, Pit J S M Kerstens, Alexandre E Voskuyl, Dirkjan van Schaardenburg, Michael T Nurmohamed, Willem F Lems
Objective: To assess the efficacy and safety of initial COBRA-light vs COBRA therapy in RA patients after a 4-year follow-up period. Methods: In the COBRA-light trial, 162 consecutive patients with recent-onset RA were randomized to either COBRA-light (prednisolone and MTX) or COBRA therapy (prednisolone, MTX and SSZ) for 1 year. After 1 year, treatment was continued without protocol, and adjusted by the treating physician according to clinical judgement, preferably with a treat-to-target strategy...
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28859325/drivers-of-patient-global-assessment-in-patients-with-rheumatoid-arthritis-who-are-close-to-remission-an-analysis-of-1588-patients
#10
Ricardo J O Ferreira, Maxime Dougados, John R Kirwan, Cátia Duarte, Maarten de Wit, Martin Soubrier, Bruno Fautrel, Tore K Kvien, José A P da Silva, Laure Gossec
Objectives: ACR/EULAR Boolean remission in RA is frequently not obtained solely due to a patient global assessment (PGA) >1/10 (a condition often designated as near-remission). This study aimed to assess which domains of impact could explain an elevated PGA in near-remission patients. Methods: We performed an ancillary analysis of data from three cross-sectional studies in patients with established RA. Three disease activity states were defined: remission (tender and swollen joint counts, CRP and PGA all ⩽1), near-remission (tender and swollen joint counts, and CRP are all ≤1 but PGA >1) and non-remission...
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28859324/vasodilation-is-not-the-only-approach-to-the-management-of-cutaneous-ulceration-in-systemic-sclerosis
#11
John D Pauling
No abstract text is available yet for this article.
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28859323/unusual-tense-bullae-on-the-legs-of-a-woman-with-rheumatoid-arthritis
#12
Hideyuki Kosumi, Teruki Yanagi, Keiko Shiba, Tatsuro Sugai, Hiroyuki Nakamura, Hiroshi Shimizu
No abstract text is available yet for this article.
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28641391/a-multicentre-study-to-improve-clinical-interpretation-of-proteinase-3-and-myeloperoxidase-anti-neutrophil-cytoplasmic-antibodies
#13
Xavier Bossuyt, Niels Rasmussen, Pieter van Paassen, Bernard Hellmich, Bo Baslund, Pieter Vermeersch, Daniel Blockmans, Jan-Willem Cohen Tervaert, Elena Csernok, Jan Damoiseaux
No abstract text is available yet for this article.
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28605535/muscle-wasting-in-male-tnf-%C3%AE-blocker-na%C3%A3-ve-ankylosing-spondylitis-patients-a-comparison-of-gender-differences-in-body-composition
#14
Sebastián Ibáñez Vodnizza, Ingrid M Visman, Christiaan van Denderen, Willem F Lems, Francisca Jaime, Michael T Nurmohamed, Irene E van der Horst-Bruinsma
Objective: To assess gender differences in body composition (BC) in a cohort of AS patients naïve to TNF-α blockers. Methods: Patients included fulfilled the Modified New York criteria for AS. Demographic information and disease activity measures (ASDAS and BASDAI) were reported. BC was measured by whole body DXA. Body fat percentage (BF%), fat mass index (FMI), fat free mass index (FFMI) and android/gynoid fat ratio were reported and compared between men and women and with the reference population (percentiles)...
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28595367/limited-value-for-ultrasonography-in-predicting-flare-in-rheumatoid-arthritis-patients-with-low-disease-activity-stopping-tnf-inhibitors
#15
Femke B Lamers-Karnebeek, Jolanda J Luime, David F Ten Cate, Steven Teerenstra, Nanno W A A Swen, Andreas H Gerards, Jos Hendrikx, Emma M van Rooyen, Ramon Voorneman, Cees Haagsma, Natalja Basoski, Mike de Jager, Marjan Ghiti Moghadam, Monique N Efde, Yvonne P M Goekoop-Ruiterman, Piet L C M van Riel, Johannes W G Jacobs, Tim L Jansen
Objective: Ultrasonography (US) can be used for treatment decisions in RA patients. This study investigated the added value of US to clinical variables in predicting flare in RA patients with longstanding low disease activity when stopping TNF inhibitors (TNFi). Methods: Cox models with and without using US added to clinical variables were developed in the Potential Optimization of Expediency of TNFi-UltraSonography study. RA patients (n = 259), using >1 year TNFi and csDMARD with DAS28 < 3...
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28595349/prenatal-exposure-to-antimalarials-decreases-the-risk-of-cardiac-but-not-non-cardiac-neonatal-lupus-a-single-centre-cohort-study
#16
Julie Barsalou, Edgar Jaeggi, Carl A Laskin, Patrick Brown, Simon Y Tian, Robert M Hamilton, Earl D Silverman
Objective: Recent studies have suggested that prenatal exposure to HCQ reduces the risk of cardiac neonatal lupus. The aim of this study is to assess if maternal intake of antimalarials (AMs) throughout pregnancy lowered the risk of cardiac and non-cardiac neonatal lupus. Methods: Consecutive children seen between 1 January 1984 to 1 October 2013 born to women with a CTD and positive anti-Ro and/or anti-La antibodies were eligible for this single-centre retrospective cohort study...
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28582539/more-than-meets-the-eye-igg4-related-disease-presenting-as-isolated-interstitial-lung-disease
#17
Aprajita Jagpal, David R Crowe, Joao A de Andrade, Maria Del Pilar Acosta Lara, Iris Navarro-Millan
No abstract text is available yet for this article.
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28582527/transcriptional-profiles-of-jia-patient-blood-with-subsequent-poor-response-to-methotrexate
#18
Halima Moncrieffe, Mark F Bennett, Monica Tsoras, Lorie K Luyrink, Anne L Johnson, Huan Xu, Jason Dare, Mara L Becker, Sampath Prahalad, Margalit Rosenkranz, Kathleen M O'Neil, Peter A Nigrovic, Thomas A Griffin, Daniel J Lovell, Alexei A Grom, Mario Medvedovic, Susan D Thompson
Objective: The mechanisms that determine the efficacy or inefficacy of MTX in JIA are ill-defined. The objective of this study was to identify a gene expression transcriptional signature associated with poor response to MTX in patients with JIA. Methods: RNA sequencing was used to measure gene expression in peripheral blood mononuclear cells collected from 47 patients with JIA prior to MTX treatment and 14 age-matched controls. Differentially expressed baseline genes between responders and non-responders were evaluated...
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28575416/toxic-drug-induced-liver-failure-during-therapy-of-rheumatoid-arthritis-with-tocilizumab-subcutaneously-a-case-report
#19
Friedrich Anger, Armin Wiegering, Johanna Wagner, Johan Lock, Johannes Baur, Lukas Haug, Marc Schmalzing, Andreas Geier, Stefan Löb, Ingo Klein
No abstract text is available yet for this article.
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28541581/a-multicentre-study-to-improve-clinical-interpretation-of-proteinase-3-and-myeloperoxidase-anti-neutrophil-cytoplasmic-antibodies
#20
Xavier Bossuyt, Niels Rasmussen, Pieter van Paassen, Bernard Hellmich, Bo Baslund, Pieter Vermeersch, Daniel Blockmans, Jan-Willem Cohen Tervaert, Elena Csernok, Jan Damoiseaux
Objective: The objective of this multicentre study was to improve the clinical interpretation of PR3- and MPO-ANCAs as an adjunct for the diagnosis of ANCA-associated vasculitis (AAV) by defining thresholds and test result intervals based on predefined specificities and by calculating test result interval-specific likelihood ratios (LRs). Methods: Eight different PR3- and MPO-ANCA immunoassays from seven companies were evaluated using 251 diagnostic samples from AAV patients and 924 diseased controls...
September 1, 2017: Rheumatology
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