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Rheumatology

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https://www.readbyqxmd.com/read/28096458/more-severe-disease-and-slower-recovery-in-younger-patients-with-anti-3-hydroxy-3-methylglutaryl-coenzyme-a-reductase-associated-autoimmune-myopathy
#1
Eleni Tiniakou, Iago Pinal-Fernandez, Thomas E Lloyd, Jemima Albayda, Julie Paik, Jessie L Werner, Cassie A Parks, Livia Casciola-Rosen, Lisa Christopher-Stine, Andrew L Mammen
OBJECTIVE: To study disease severity and response to therapy in a large cohort of patients with anti-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)-associated myositis. METHODS: Muscle strength, creatine kinase levels and treatments were assessed in anti-HMGCR-positive patients at each clinical visit. Univariate and multivariate analyses were used to analyse the influence of clinical characteristics on strength and the change in strength over time. Whole exome sequencing was performed in a subset of patients...
January 17, 2017: Rheumatology
https://www.readbyqxmd.com/read/28096457/the-predictive-value-of-serum-s100a9-and-response-to-etanercept-is-not-confirmed-in-a-large-uk-rheumatoid-arthritis-cohort
#2
Samantha Louise Smith, Darren Plant, Stephen Eyre, Kimme Hyrich, Ann W Morgan, Anthony G Wilson, John D Isaacs, Anne Barton
OBJECTIVE: The aim was to correlate protein concentrations of S100A9 in pretreatment serum samples with response to the tumour-necrosis factor (TNF) inhibitor drugs etanercept in a large UK replication cohort. METHODS: Pretreatment serum samples from patients with RA (n = 236) about to commence treatment with etanercept had S100A9 serum concentration measured using an ELISA. Following the experimental procedure, S100A9 concentrations were analysed with respect to EULAR response...
January 16, 2017: Rheumatology
https://www.readbyqxmd.com/read/28087832/comparison-of-cardiovascular-risk-algorithms-in-patients-with-vs-without-rheumatoid-arthritis-and-the-role-of-c-reactive-protein-in-predicting-cardiovascular-outcomes-in-rheumatoid-arthritis
#3
Evo Alemao, Hélène Cawston, François Bourhis, Maiwenn Al, Maureen Rutten-van Molken, Katherine P Liao, Daniel H Solomon
OBJECTIVES: The aims were to compare the performance of cardiovascular risk calculators, Framingham Risk Score (FRS) and QRISK2, in RA and matched non-RA patients and to evaluate whether their performance could be enhanced by the addition of CRP. METHODS: We conducted a retrospective analysis, using a clinical practice data set linked to Hospital Episode Statistics (HES) data from the UK. Patients presenting with at least one RA diagnosis code and no prior cardiovascular events were matched to non-RA patients using disease risk scores...
January 12, 2017: Rheumatology
https://www.readbyqxmd.com/read/28082622/myositis-associated-usual-interstitial-pneumonia-has-a-better-survival-than-idiopathic-pulmonary-fibrosis
#4
Rohit Aggarwal, Christine McBurney, Frank Schneider, Samuel A Yousem, Kevin F Gibson, Kathleen Lindell, Carl R Fuhrman, Chester V Oddis
OBJECTIVE: To compare the survival outcomes between myositis-associated usual interstitial pneumonia (MA-UIP) and idiopathic pulmonary fibrosis (IPF-UIP). METHODS: Adult MA-UIP and IPF-UIP patients were identified using CTD and IPF registries. The MA-UIP cohort included myositis or anti-synthetase syndrome patients with interstitial lung disease while manifesting UIP on high-resolution CT chest and/or a lung biopsy revealing UIP histology. IPF subjects met American Thoracic Society criteria and similarly had UIP histopathology...
January 12, 2017: Rheumatology
https://www.readbyqxmd.com/read/28082621/ccr5%C3%AE-32-and-the-genetic-susceptibility-to-rheumatoid-arthritis-in-admixed-populations-a-multicentre-study
#5
LETTER
Bruno Toson, Eduardo José Dos Santos, José Eduardo Adelino, Paula Sandrin-Garcia, Sergio Crovella, Paulo Louzada-Júnior, Renê Donizete Ribeiro Oliveira, Larysse Santa Rosa Aquino Pedroza, Maria de Fátima Lobato Cunha Sauma, Clayton Pereira Silva de Lima, Fabiola Brasil Barbosa, Claiton Viegas Brenol, Ricardo Machado Xavier, José Artur Bogo Chies, Tiago Degani Veit
No abstract text is available yet for this article.
January 12, 2017: Rheumatology
https://www.readbyqxmd.com/read/28082620/long-term-persistence-and-adherence-on-urate-lowering-treatment-can-be-maintained-in-primary-care-5-year-follow-up-of-a-proof-of-concept-study
#6
Abhishek Abhishek, Wendy Jenkins, Jonathan La-Crette, Gwen Fernandes, Michael Doherty
OBJECTIVES: To evaluate the persistence and adherence on urate-lowering treatment (ULT) in primary care 5 years after an initial nurse-led treatment of gout. METHODS: One hundred gout patients initiated on up-titrated ULT between March and July 2010 were sent a questionnaire that elicited information on current ULT, reasons for discontinuation of ULT if applicable, medication adherence and generic and disease-specific quality-of-life measures in 2015. They were invited for one visit at which height and weight were measured and blood was collected for serum uric acid measurement...
January 12, 2017: Rheumatology
https://www.readbyqxmd.com/read/28077693/new-grappa-and-eular-recommendations-for-the-management-of-psoriatic-arthritis-process-and-challenges-faced
#7
EDITORIAL
Laura C Coates, Laure Gossec, Sofia Ramiro, Philip Mease, Désirée van der Heijde, Josef S Smolen, Christopher Ritchlin, Arthur Kavanaugh
No abstract text is available yet for this article.
January 11, 2017: Rheumatology
https://www.readbyqxmd.com/read/28077692/reference-curves-for-the-australian-canadian-hand-osteoarthritis-index-in-the-middle-aged-dutch-population
#8
Féline P B Kroon, Sofia Ramiro, Patrick Royston, Saskia Le Cessie, Frits R Rosendaal, Margreet Kloppenburg
OBJECTIVE: The aim was to establish reference curves of the Australian/Canadian Hand Osteoarthritis Index (AUSCAN), a widely used questionnaire assessing hand complaints. METHODS: Analyses were performed in a population-based sample, The Netherlands Epidemiology of Obesity study (n = 6671, aged 45-65 years). Factors associated with AUSCAN scores were analysed with ordered logistic regression, because AUSCAN data were zero inflated, dividing AUSCAN into three categories (0 vs 1-5 vs >5)...
January 11, 2017: Rheumatology
https://www.readbyqxmd.com/read/28077691/establishment-and-baseline-characteristics-of-a-nationwide-danish-cohort-of-patients-with-ehlers-danlos-syndrome
#9
Marie-Louise Kulas Søborg, Julie Leganger, Laura Quitzau Mortensen, Jacob Rosenberg, Jakob Burcharth
OBJECTIVES: The aim of this study was to investigate national prevalence, general demographic characteristics and survival of Danish patients with Ehlers-Danlos syndrome (EDS). METHOD: A population-based cohort study was conducted using a database consisting of the entire Danish population alive at any given time between 1 January 2000 and 31 December 2012, based upon longitudinal Danish national registers. All patients with EDS were identified, and the cohort was described by disease prevalence, basic demographic characteristics, mean age at death and mortality for the observational period of 13 years...
January 11, 2017: Rheumatology
https://www.readbyqxmd.com/read/28077690/educating-people-with-rare-rheumatological-conditions-patients-deserve-better
#10
EDITORIAL
Janice Mooney, Richard A Watts
No abstract text is available yet for this article.
January 11, 2017: Rheumatology
https://www.readbyqxmd.com/read/28077689/giant-cell-arteritis-and-vascular-disease-risk-factors-and-outcomes-a-cohort-study-using-uk-clinical-practice-research-datalink
#11
Lin Li, Tuhina Neogi, Susan Jick
OBJECTIVE: To evaluate the associations between GCA and vascular diseases and other comorbidities in patients with GCA compared with non-vasculitis patients. METHODS: Using the UK-based Clinical Practice Research Datalink we identified 9778 newly diagnosed GCA patients in 1990-2014, and up to 10 non-vasculitis patients randomly matched to each case on age, sex, practice and years of history before cohort entry. We compared the distributions of 9 different pre-existing vascular diseases and 11 other comorbidities, and risks of incident vascular diseases and other comorbidities after cohort entry between GCA and non-vasculitis patients...
January 11, 2017: Rheumatology
https://www.readbyqxmd.com/read/28073957/primary-inefficacy-of-tnf-inhibitors-in-patients-with-axial-spondyloarthritis-a-long-term-follow-up-of-25-patients
#12
Sandra Kossi, Sabrina Dadoun, Guillaume Geri, Aurore Hermet, Bruno Fautrel, Maxime Dougados, Laure Gossec
OBJECTIVES: Primary inefficacy of TNF inhibitors (TNFi) for axial spondyloarthritis (axSpA) is infrequent. The objective of this study was to assess the long-term evolution and final diagnosis of patients with primary inefficacy of TNFi for axSpA. METHODS: This was a systematic retrospective study of all patients receiving a TNFi for axSpA in one tertiary referral centre. Patients had axSpA confirmed by a rheumatologist and were started on a first course of TNFi according to usual practice...
January 9, 2017: Rheumatology
https://www.readbyqxmd.com/read/28073956/the-effect-of-rheumatoid-arthritis-associated-autoantibodies-on-the-incidence-of-cardiovascular-events-in-a-large-inception-cohort-of-early-inflammatory-arthritis
#13
Lillian J Barra, Janet E Pope, Carol Hitchon, Gilles Boire, Orit Schieir, Daming Lin, Carter J Thorne, Diane Tin, Edward C Keystone, Boulos Haraoui, Shahin Jamal, Vivian P Bykerk
OBJECTIVE: RA is associated with an increased risk of cardiovascular events (CVEs). The objective was to estimate independent effects of RA autoantibodies on the incident CVEs in patients with early RA. METHODS: Patients were enrolled in the Canadian Early Inflammatory Arthritis Cohort, a prospective multicentre inception cohort. Incident CVEs, including acute coronary syndromes and cerebrovascular events, were self-reported by the patient and partially validated by medical chart review...
January 9, 2017: Rheumatology
https://www.readbyqxmd.com/read/28073955/establishment-of-a-rat-model-of-thrombosis-induced-by-intravenous-injection-of-anti-phosphatidylserine-prothrombin-complex-antibody
#14
Mai Yamada, Tamihiro Kawakami, Kohei Takashima, Yusuke Nishioka, Yuka Nishibata, Sakiko Masuda, Shigeru Yoshida, Utano Tomaru, Akihiro Ishizu
OBJECTIVE: Recent studies have suggested that aPS-PT antibody is one of the most relevant autoantibodies to APS. This study aimed to demonstrate the pathogenicity of aPS-PT antibody in vivo METHODS: At first, cultured rat vascular endothelial cells (RECs) were exposed to calf thymus-derived histones. Two hours later, lactate dehydrogenase release from the RECs and expression of PS on the cell surface were assessed. Next, we administered an i.v. injection of calf thymus-derived histones into Wistar rats (12...
January 9, 2017: Rheumatology
https://www.readbyqxmd.com/read/28064210/characteristics-of-autoantibodies-targeting-14-3-3-proteins-and-their-association-with-clinical-features-in-newly-diagnosed-giant-cell-arteritis
#15
Anne Kistner, Marc B Bigler, Kathrin Glatz, Simon B Egli, Fabian S Baldin, Florian A Marquardsen, Matthias Mehling, Katharina M Rentsch, Daniel Staub, Markus Aschwanden, Mike Recher, Thomas Daikeler, Christoph T Berger
OBJECTIVES: Autoantibodies are useful biomarkers for diagnosing and monitoring treatment in some autoimmune diseases. Antibodies against isoforms of 14-3-3 protein have been proposed as biomarkers for the presence of aortic aneurysm in large-vessel vasculitis (LVV). Here, we aimed to evaluate the diagnostic role and potential immunopathological involvement of anti-14-3-3 antibodies in newly diagnosed LVV patients. METHODS: Antibodies against three isoforms of 14-3-3 (γ, ε and ζ) were measured in 90 subjects: 48 GCA and 3 Takayasu's arteritis (TA) patients, and 39 controls (non-inflammatory and inflammatory diseases), using a multiplexed bead-based immunoassay and immunoprecipitation studies...
January 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/28064209/efficacy-and-effectiveness-of-tumour-necrosis-factor-inhibitors-in-the-treatment-of-rheumatoid-arthritis-in-randomized-controlled-trials-and-routine-clinical-practice
#16
Kalle J Aaltonen, Suvi Ylikylä, Jaana Tuulikki Joensuu, Pia Isomäki, Laura Pirilä, Markku Kauppi, Tuomas Rannio, Kari Eklund, Marja Blom, Dan Nordström
OBJECTIVE: Efficacy of TNF inhibitors in the treatment of RA assessed in randomized controlled trials (RCTs) may not be fully comparable to routine care owing to the stringent inclusion criteria. The objective of this study was to observe the effectiveness of TNF inhibitors in real-world patients and assess the patients' potential eligibility for the RCTs. METHODS: RA patients starting a TNF-inhibitor treatment between 2004 and 2014 were identified from the National Register for Biologic Treatment in Finland, which is a longitudinal observational cohort study...
January 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/28064208/work-disability-in-non-radiographic-axial-spondyloarthritis-patients-before-and-after-start-of-anti-tnf-therapy-a-population-based-regional-cohort-study-from-southern-sweden
#17
Johan K Wallman, Anna Jöud, Tor Olofsson, Lennart T H Jacobsson, Henning Bliddal, Lars E Kristensen
OBJECTIVE: The aim was to assess work-loss days before and after commencement of anti-TNF treatment in patients with non-radiographic axial spondylarthritis (nr-axSpA). METHODS: Bionaïve nr-axSpA patients (n = 75), aged 17-62 years, fulfilling the Assessment of SpondyloArthritis international Society criteria for axial spondyloarthritis and starting anti-TNF treatment during 2004-11, were retrieved from the observational South Swedish Arthritis Treatment Group study...
January 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/28064207/rheumatoid-arthritis-is-getting-less-frequent-results-of-a-nationwide-population-based-cohort-study
#18
Abhishek Abhishek, Michael Doherty, Chang-Fu Kuo, Christian D Mallen, Weiya Zhang, Matthew J Grainge
OBJECTIVES: The objectives of this study were to examine changes in the incidence and prevalence of RA between 1990 and 2014 and to explore if there is any geographic variation in the incidence and prevalence of RA in the UK. METHODS: This was a primary care-based prospective cohort study. People contributing acceptable data to Clinical Practice Research Datalink between 1 January 1990 and 31 December 2014 were included. Read codes were used to identify RA cases ⩾18 years of age...
January 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/28064211/a-timely-review-series-on-sle
#19
EDITORIAL
Anna-Marie Fairhurst
No abstract text is available yet for this article.
January 6, 2017: Rheumatology
https://www.readbyqxmd.com/read/28053277/auto-antibodies-to-double-stranded-dna-as-biomarker-in-systemic-lupus-erythematosus-comparison-of-different-assays-during-quiescent-and-active-disease
#20
Karina de Leeuw, Laura Bungener, Caroline Roozendaal, Hendrika Bootsma, Coen A Stegeman
OBJECTIVE: Auto-antibodies directed to dsDNA (anti-dsDNA) are used in diagnosis and follow-up for SLE. However, multiple assays are used. The objective of this study was to determine the best-performing assays, especially in prediction of exacerbations. METHODS: Seven assays were compared during LN (n = 58). The two assays with the most frequent positive results during active nephritis were selected and tested in 152 SLE patients with quiescent disease, 40 with active disease and 214 disease controls...
January 3, 2017: Rheumatology
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