We have located links that may give you full text access.
Peripheral hypercapnic chemosensitivity at rest and progressive exercise intensities in males and females.
Journal of Applied Physiology 2023 December 22
Peripheral hypercapnic chemosensitivity (PHC) is the ventilatory response to hypercapnia and is enhanced with acute whole-body exercise. However, little is known about the mechanism(s) responsible for the exercise related increase in PHC and if progressive exercise leads to further augmentation. We hypothesized that unloaded cycle exercise (0W) would increase PHC but progressively increasing the intensity would not further augment the response. Twenty healthy subjects completed 2 testing days. Day 1 was a maximal exercise test on a cycle ergometer to determine peak power output (Wmax ). Day 2 consisted of six 12-minute stages: (i) rest on chair, (ii) rest on bike, (iii) 0W unloaded cycling, (iv) 25% Wmax , (v) 50% Wmax , and (vi) ~70% Wmax with ~10 min of rest between each exercise stage. In each stage, PHC was assessed via 2 breaths of 10% CO2 (~21% O2 ) repeated 5 times with ~45s between each to ensure end-tidal CO2 (PET CO2 ) and ventilation returned to baseline. Pre-stimulus PET CO2 was not different between rest and unloaded cycling ( p =0.478). There was a significant increase in PHC between seated rest and 25% Wmax (0.71±0.37 vs. 1.03±0.52 LmmHg-1 min-1 , respectively p =0.0006), and between seated rest and unloaded cycling (0.71±0.37 vs. 1.04±0.4 LmmHg-1 min-1 , respectively p =0.0017). There was no effect of exercise intensity on PHC (1.03±0.52 vs. 0.95±0.58 vs. 1.01±0.65 LmmHg-1 min-1 for 25, 50 and 70% Wmax , p =0.44). The increased PHC response from seated rest to unloaded and 25% Wmax , but no effect of exercise intensity suggests a possible feedforward/feedback mechanism causing increased PHC sensitivity through the act of cycling.
Full text links
Related Resources
Trending Papers
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Prevention and treatment of ischaemic and haemorrhagic stroke in people with diabetes mellitus: a focus on glucose control and comorbidities.Diabetologia 2024 April 17
British Society for Rheumatology guideline on management of adult and juvenile onset Sjögren disease.Rheumatology 2024 April 17
Diagnosis and Management of Cardiac Sarcoidosis: A Scientific Statement From the American Heart Association.Circulation 2024 April 19
Albumin: a comprehensive review and practical guideline for clinical use.European Journal of Clinical Pharmacology 2024 April 13
Eosinophilic Esophagitis: Clinical Pearls for Primary Care Providers and Gastroenterologists.Mayo Clinic Proceedings 2024 April
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app