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Journal of Applied Physiology

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https://www.readbyqxmd.com/read/28209743/skeletal-muscle-bioenergetics-during-all-out-exercise-mechanistic-insight-into-the-oxygen-uptake-slow-component-and-neuromuscular-fatigue
#1
Ryan M Broxterman, Gwenael Layec, Thomas J Hureau, Markus Amann, Russell S Richardson
Although commonly used, the physiological mechanisms underlying all-out exercise performance are still unclear and an in-depth assessment of skeletal muscle bioenergetics is lacking. Therefore, phosphorous magnetic resonance spectroscopy ((31)P-MRS) was utilized to assess skeletal muscle bioenergetics during a 5-min all-out intermittent isometric knee-extensor protocol in 8 healthy men. The metabolic perturbation, adenosine triphosphate (ATP) synthesis rates, ATP cost of contraction, and mitochondrial capacity were determined from intramuscular concentrations of phosphocreatine (PCr), inorganic phosphate (Pi), diprotonated phosphate (H2PO4⁻ ), and pH...
February 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28209742/cardiorespiratory-fitness-modulates-the-acute-flow-mediated-dilation-response-following-high-intensity-but-not-moderate-intensity-exercise-in-elderly-men
#2
Tom G Bailey, Maria Perissiou, Mark Windsor, Fraser D Russell, Jonathan Golledge, Daniel J Green, Christopher D Askew
Impaired endothelial function is observed with ageing and with low cardiorespiratory fitness (VO2peak) whilst improvements in both are suggested to be reliant on higher-intensity exercise in the elderly. This may be due to the flow-mediated dilation (FMD) response to acute exercise of varying intensity. We examined the hypothesis that exercise-intensity alters the FMD response in healthy elderly adults, and would be modulated by VO2peak Forty-seven elderly men were stratified into lower- (VO2peak = 24.3±2...
February 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28209741/frequency-characteristics-of-human-muscle-and-cortical-responses-evoked-by-noisy-achilles-tendon-vibration
#3
Robyn Lynne Mildren, Ryan M Peters, Aimee J Hill, Jean-Sebastien Blouin, Mark Gregory Carpenter, J Timothy Inglis
Noisy stimuli, along with linear systems analysis, have proven to be effective for mapping functional neural connections. We explored the use of noisy (10-115 Hz) Achilles tendon vibration to examine proprioceptive reflexes in the triceps surae muscles in standing healthy young adults (n = 8). We also examined the association between noisy vibration and electrical activity recorded over the sensorimotor cortex using electroencephalography. We applied two-minutes of vibration and recorded ongoing muscle activity of the soleus and gastrocnemii using surface electromyography (EMG)...
February 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28209740/quantitative-mri-volumetry-diffusivity-cerebrovascular-flow-and-cranial-hydrodynamics-during-head-down-tilt-and-hypercapnia-the-spacecot-study
#4
Larry Allen Kramer, Khader M Hasan, Ashot E Sargsyan, Karina Marshall-Goebel, Jörn Rittweger, Dorit Donoviel, Saki Higashi, Benson Mwangi, Darius A Gerlach, Eric M Bershad
PURPOSE: In order to improve the pathophysiologic understanding of visual changes observed in astronauts, we aimed to use quantitative MRI to measure anatomic and physiologic responses during a ground-based spaceflight analogue (head down tilt, HDT) combined with increased ambient carbon dioxide (CO2). METHODS: Six healthy, male subjects participated in the double-blinded, randomized cross-over design study with two conditions: 26.5 h of -12° HDT with ambient air and with 0...
February 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28209739/myocardial-ischemic-tolerance-in-rats-subjected-to-endurance-exercise-training-during-adaptation-to-chronic-hypoxia
#5
Petra Alánová, Anna Chytilová, Jan Neckář, Jaroslav Hrdlička, Petra Míčová, Kristýna Holzerová, Markéta Hlaváčková, Kristýna Macháčková, František Papoušek, Jana Vašinová, Daniel Benák, Olga Nováková, František Kolář
Chronic hypoxia and exercise are natural stimuli that confer sustainable cardioprotection against ischemia/reperfusion (I/R) injury but it is unknown whether they can act in synergy to enhance ischemic resistance. Inflammatory response mediated by tumor necrosis factor-α (TNF-α) plays a role in the infarct size-limitation by continuous normobaric hypoxia (CNH) whereas exercise is associated with anti-inflammatory effects. This study was conducted to determine whether exercise training performed under conditions of CNH (12% O2) affects myocardial ischemic resistance with respect to inflammatory and redox status...
February 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28183823/occlusion-of-blood-flow-attenuates-exercise-induced-hypoalgesia-in-the-occluded-limb-of-healthy-adults
#6
Matthew D Jones, Janet L Taylor, Benjamin K Barry
Animal studies have demonstrated an important role of peripheral mechanisms as contributors to exercise-induced hypoalgesia (EIH). Whether these same mechanisms contribute to EIH in humans is not known. In the current study, pain thresholds were assessed in healthy volunteers (n = 36) before and after 5 min of high intensity leg cycling exercise and an equivalent period of quiet rest. Pressure pain thresholds (PPT) were assessed over the rectus femoris muscle of one leg and first dorsal interosseous muscles (FDI) of both arms...
February 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28183822/development-of-a-technique-for-determination-of-pulmonary-artery-pulse-wave-velocity-in-horses
#7
Gonçalo Teixeira de Almeida Silva, Bruce B Guest, Diego E Gomez, Martine McGregor, Laurent Viel, M Lynne O'Sullivan, John Runciman, Luis G Arroyo
Calcification of the tunica media of the axial pulmonary arteries (PA) has been reported in a large proportion of racehorses. In humans, medial calcification is a significant cause of arterial stiffening and is implicated in the pathogenesis of cardiac, cerebral and renal microvascular diseases. Pulse wave velocity (PWV) provides a measure of arterial stiffness. This study aimed to develop a technique to determine PA-PWV in horses, and secondarily to investigate a potential association between PA-PWV and arterial fibro-calcification...
February 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28183821/exercise-induced-upregulation-of-endothelial-adhesion-molecules-in-human-skeletal-muscle-and-number-of-circulating-cells-with-remodeling-properties
#8
Anna Strömberg, Eric Rullman, Eva Jansson, Thomas Gustafsson
Multipotent cells have received great interest due to their potential capacity to repair and remodel peripheral tissues. We examined the effect of an acute exercise bout on the number of circulating cells with known remodeling properties, and the level of factors in plasma and skeletal muscle tissue with potential to recruit these cells. Twenty healthy male subjects performed a 60 min cycling exercise. Blood samples for flow cytometry were drawn from 10 subjects (Group 1) before and up to 2 h after exercise, and absolute cell counts of the classical (CD14(++)CD16(-)), intermediate (CD14(++)CD16(+)), and nonclassical (CD14(+)CD16(++)) monocyte (MO) subpopulations, and of CD45(dim)CD34(+)VEGFR2(+) endothelial progenitor cells (EPCs) were measured using bead-based determination...
February 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28183820/sarcolipin-expression-is-not-required-for-the-mitochondrial-enzymatic-response-to-physical-activity-or-diet
#9
Daniel Gamu, Anton Trinh, Val A Farjado, Eric Bombardier, A Russell Tupling
In mice, transgenic manipulation of Ca(2+)-handling proteins is sufficient to alter the metabolic phenotype of muscle. We have previously shown that ablation of sarcolipin (SLN), a regulatory protein and uncoupler of sarco(endo)plasmic reticulum Ca(2+)-ATPases, leads to excessive diet-induced obesity and glucose intolerance in mice. However, it is unclear how loss of SLN per se affects muscle oxidative capacity and the ability of mitochondria to adapt to physiological stimuli such as exercise training or calorie overload...
February 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28183819/a-chronic-physical-activity-treatment-in-obese-rats-normalizes-the-contributions-of-et-1-and-no-to-insulin-mediated-posterior-cerebral-artery-vasodilation
#10
T Dylan Olver, Matthew W McDonald, Diana Klakotskaia, Rachel A Richardson, Jeffrey L Jasperse, C W James Melling, Todd R Schachtman, Hsiao T Yang, Craig A Emter, M Harold Laughlin
This study tested the hypotheses that obesity-induced decrements in insulin-stimulated cerebrovascular vasodilation would be normalized with acute endothelin-1a receptor antagonism, and treatment with a physical activity intervention restores vasoreactivity to insulin through augmented nitric oxide synthase (NOS)-dependent dilation. Otsuka Long-Evans Tokushima Fatty rats were divided into the following groups; 20-wk old food-controlled (CON-20); 20-wk old free-food access (model of obesity, OB-20); 40-wk old food-controlled (CON-40); 40-wk old free-food access (OB-40); and 40-wk old free-food access+RUN (RUN-40; wheel-running access from 20-40 wk)...
February 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28183818/normalization-of-hemoglobin-based-oxygen-carrier-201-induced-vasoconstriction-roles-of-nitric-oxide-scavenging-and-endothelin
#11
Yannick J Taverne, Daphne P M de Wijs-Meijler, Maaike Te Lintel Hekkert, Paula F Moon-Massat, Greg P Dubé, Dirk Jan Duncker, Daphne Merkus
BACKGROUND: Hemoglobin-based oxygen carrier (HBOC)-201 is a cell-free modified hemoglobin solution potentially facilitating oxygen uptake and delivery in cardiovascular disorders and hemorrhagic shock. Clinical use has been hampered by vasoconstriction in the systemic and pulmonary beds. Therefore we aimed to 1) determine the possibility of counteracting HBOC-201-induced pressor effects with adenosine (ADO), 2) assess the potential roles of nitric oxide (NO) scavenging, reactive oxygen species (ROS) and endothelin (ET) in mediating the observed vasoconstriction and 3) compare these effects in resting and exercising swine...
February 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28183817/comparison-between-the-phase-angle-and-phase-shift-parameters-to-assess-thoracoabdominal-asynchrony-in-copd-patients
#12
Desiderio Cano Porras, Adriana C Lunardi, Cibele C B Marques da Silva, Denise M Paisani, Rafael Stelmach, Henrique Takachi Moriya, Celso R F Carvalho
BACKGROUND: Determining the presence of thoracoabdominal asynchrony in chronic obstructive pulmonary disease patients is clinically relevant, but there is no consensus on the optimal parameters for performing this analysis. METHODS: We assessed 22 COPD patients (FEV1 40±10% predicted) and 13 healthy controls during rest and exercise with optoelectronic plethysmography (70% maximum workload) on a cycle ergometer. Thoracoabdominal asynchrony was calculated by using phase angle and phase shift parameters following a three-compartment model involving the upper and lower ribcages and abdomen...
February 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28183816/two-weeks-of-moderate-intensity-continuous-training-but-not-high-intensity-interval-training-increases-insulin-stimulated-intestinal-glucose-uptake
#13
Kumail Kumar Motiani, Anna M Savolainen, Jari-Joonas Eskelinen, Jussi Toivanen, Tamiko Ishizu, Minna Yli-Karjanmaa, Kirsi A Virtanen, Riitta Parkkola, Jukka Kapanen, Tove J Gronroos, Merja Haaparanta-Solin, Olof Solin, Nina Savisto, Markku Ahotupa, Eliisa Löyttyniemi, Juhani Knuuti, Pirjo Nuutila, Kari K Kalliokoski, Jarna C Hannukainen
Similar to muscles, the intestine is also insulin resistant in obese subjects and subjects with impaired glucose tolerance. Exercise training improves muscle insulin sensitivity, but its effects on intestinal metabolism are not known. We studied the effects of high intensity interval training (HIIT) and moderate intensity continuous training (MICT) on intestinal glucose and free fatty acid uptake from circulation in humans. Twenty-eight healthy middle-aged sedentary men were randomized for two weeks of HIIT or MICT...
February 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28153947/corp-measurement-of-the-maximum-oxygen-uptake-vo2max-vo2peak-is-no-longer-acceptable
#14
David C Poole, Andrew M Jones
The maximum rate of VO2 uptake (i.e., VO2max), as measured during large muscle mass exercise such as cycling or running, is widely considered to be the gold standard measurement of integrated cardiopulmonary-muscle oxidative function. The development of rapid-response gas analyzers, enabling measurement of breath-by-breath pulmonary gas exchange, has led to replacement of the discontinuous progressive maximal exercise test (that produced an unambiguous VO2-work rate plateau definitive for VO2max) with the rapidly-incremented or ramp testing protocol...
February 2, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28153946/effects-and-prevalence-of-non-responders-after-12weeks-of-high-intensity-interval-or-resistan-training-in-adult-woman-with-insulin-resistance-a-randomized-trial
#15
Cristian Alvarez, Rodrigo Ramírez-Campillo, Robinson Ramírez-Vélez, Mikel Izquierdo
AIMS/HYPOTHESIS: Our aim was to investigate the effects and prevalence of non-responders (NR) to high-intensity interval training (HIIT) and resistant training (RT)in adult woman with insulin resistance on cardiometabolic health parameters. METHODS: Sedentary overweight/obese insulin resistant adult women (age = 33.5 ±6.5 years;BMI=29.9 ± 3.7kg/m2) were randomly assigned to a tri-weekly HIIT program(HIIT;n=18) or resistant training (RT;n=17).Anthropometry (body mass, fat mas, muscle mass, waist circumference and skinfolds thickness),cardiovascular(blood pressure), metabolic (fasting glucose, fasting insulin and HOMA-IR),as well muscle strength, and endurance performance co-variables were measured before and after 12 weeks in both intervention groups...
February 2, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28153945/metabolic-imaging-in-exercise-physiology
#16
Thorsten Rudroff, Nathaniel B Ketelhut, John H Kindred
This mini-review focuses on selected, noninvasive imaging techniques that have been used in the study of exercise physiology. These imaging modalities can be roughly divided into two categories: tracer based and non-tracer based. Tracer based methods use radio-labeled substrates whose location and quantity can subsequently be imaged once they are incorporated into metabolic processes. Non-tracer based imaging modalities rely on specific properties of substrates to identify metabolites and determine their concentrations...
February 2, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28153944/involvement-of-glycogen-synthase-kinase-3%C3%AE-in-liver-ischemic-conditioning-induced-cardioprotection-against-myocardial-ischemia-and-reperfusion-injury-in-rats
#17
Shuai Yang, Geoffrey W Abbott, Wei Dong Gao, Jin Liu, Chaozhi Luo, Zhaoyang Hu
Remote ischemic conditioning has been convincingly shown to render the myocardium resistant to a subsequent more severe sustained episode of ischemia. Compared to other organs, little is known regarding the effect of transient liver ischemic conditioning. We proposed the existence cardioprotection induced by remote liver conditioning. Male Sprague Dawley rats were divided into sham-operated, control(CON, no further hepatic intervention) and remote liver ischemic conditioning groups. For liver ischemic conditioning, three cycles of 5min of liver ischemia/reperfusion stimuli were conducted prior to-(liver preconditioning), post-myocardial ischemia (liver postconditioning), or in combination of both (liver preconditioning+liver postconditioning)...
February 2, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28153943/the-cardiovascular-system-after-exercise
#18
Steven A Romero, Christopher Todd Minson, John R Halliwill
Recovery from exercise refers to the time period between the end of a bout of exercise and the subsequent return to a resting or recovered state. It also refers to specific physiological processes or states, occurring after exercise, which are distinct from the physiology of either the exercising or the resting states. In this context, recovery of the cardiovascular system after exercise occurs across a period of minutes to hours, during which many characteristics of the system, even how it is controlled, are changing over time...
February 2, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28153942/divergent-endothelial-function-but-similar-platelet-microvesicle-responses-following-eccentric-and-concentric-cycling-at-a-similar-aerobic-power-output
#19
Mark Rakobowchuk, Ophélie Ritter, Eurico Nestor Wilhelm, Laurie Isacco, Malika Bouhaddi, Bruno Degano, Nicolas Tordi, Laurent Mourot
Endothelial function and microvesicle concentration changes after acute bouts of continuous eccentric exercise have not been assessed previously nor compared to concentric exercise at similar aerobic power outputs. This method of training may be useful amongst some clinical populations, but acute responses are not well described. As such, twelve healthy males completed two experimental sessions of either 45 minutes of eccentric or concentric cycling at a matched aerobic power output below the ventilatory threshold...
February 2, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28153941/decreases-in-maximal-oxygen-uptake-following-long-duration-spaceflight-role-of-convective-and-diffusive-o2-transport-mechanisms
#20
Carl J Ade, Ryan M Broxterman, Alan Moore, Thomas J Barstow
We have previously predicted that the decrease in maximal oxygen uptake (VO2max) that accompanies time in microgravity reflects decrements in both convective and diffusive O2 transport to the mitochondria of the contracting myocytes. The aim of this investigation was therefore to quantify the relative changes in convective O2 transport (QO2) and O2 diffusing capacity (DO2) following long duration spaceflight. In 9 astronauts, resting hemoglobin concentration ([Hb]), VO2max, maximal cardiac output (QTmax), and differences in arterial and venous O2 contents (CaO2-CvO2) were obtained retrospectively for International Space Station Increments 19 through 33 (April 2009-November 2012)...
February 2, 2017: Journal of Applied Physiology
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