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Journal of Applied Physiology

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https://www.readbyqxmd.com/read/28706001/aspirin-as-a-cox-inhibitor-and-anti-inflammatory-drug-in-human-skeletal-muscle
#1
Steve M Ratchford, Kaleen M Lavin, Ryan K Perkins, Bozena Jemiolo, Scott W Trappe, Todd A Trappe
Although aspirin is one of the most common anti-inflammatory drugs in the world, the effect of aspirin on human skeletal muscle inflammation is almost completely unknown. This study examined the potential effects and related time course of an orally consumed aspirin dose on the inflammatory PGE2/COX pathway in human skeletal muscle. Skeletal muscle biopsies were taken from the vastus lateralis of 10 healthy adults (5M/5F, 25±2y) before and 2, 4, and 24h after consuming a standard dose of aspirin (975mg) and partitioned for analysis of 1) in vivo PGE2 levels in resting skeletal muscle and 2) ex vivo skeletal muscle PGE2 production when stimulated with the COX substrate arachidonic acid (5μM)...
July 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28706000/absence-of-compensatory-vasodilation-with-perfusion-pressure-challenge-in-exercise-evidence-for-and-implications-of-the-non-compensator-phenotype
#2
Robert F Bentley, Jeremy J Walsh, Patrick J Drouin, Aleksandra Velickovic, Sarah J Kitner, Alyssa M Fenuta, Michael E Tschakovsky
Compromising oxygen delivery (O2D) during exercise requires compensatory vasodilatory and/or pressor responses to protect O2D : demand matching. The purpose of the study was to determine whether compensatory vasodilation is absent in some healthy, young individuals in the face of a sudden reduction in exercising forearm perfusion pressure, and whether this affects the exercise pressor response. 21 healthy, young males (21.6±2.0yrs) completed rhythmic forearm exercise at a work rate equivalent to 70% of their own maximal exercise vasodilation...
July 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28705999/the-effects-of-strict-prolonged-bedrest-on-cardio-respiratory-fitness-systematic-review-and-meta-analysis
#3
Mathias Ried-Larsen, Hugo Aarts, Michael J Joyner
The aim of this systematic review and meta-analysis (PROSPERO: CRD42017055619) was to assess the effects of strict prolonged bedrest (without counter measures) on V̇O2max and to explore sources of variation herein. Since 1949, 80 studies with a total of 949 participants (>90% males) have been published with data on strict bedrest and V̇O2max. The studies were conducted mainly in young participants (median age (interquartile range)) 24.5 (22.4 to 34.0) years. The duration of bedrest ranged from 1-90 days...
July 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28705998/is-normobaric-hypoxia-an-effective-treatment-for-sustaining-previously-acquired-altitude-acclimatization
#4
Beth A Beidleman, Charles S Fulco, Bruce S Cadarette, Allen Cymerman, Mark J Buller, Roy M Salgado, Alexander M Posch, Janet E Staab, Ingrid V Sils, Beau R Yurkevicius, Adam J Luippold, Alexander P Welles, Stephen R Muza
This study examined whether normobaric hypoxia (NH) treatment is more efficacious for sustaining high altitude (HA) acclimatization during re-introduction to altitude (RA) than no treatment at all. Seventeen sea level (SL) residents (age=23±6yrs; mean±SE) completed in the following order: 1)4d of SL testing, 2)12d of high altitude (HA) acclimatization at 4300m, 3)12d at SL post HA acclimatization (Post) where each received either NH (n=9;FiO2=0.122) or Sham (n=8;FiO2=0.207) treatment, and 4)24-h re-introduction to 4300m altitude (RA) in a hypobaric chamber...
July 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28705997/evidence-from-high-altitude-acclimatization-for-an-integrated-cerebrovascular-and-ventilatory-hypercapnic-response-but-different-responses-to-hypoxia
#5
Zachary M Smith, Erin Krizay, Rui Carlos Sa, Ethan T Li, Miriam Scadeng, Frank L Powell, David J Dubowitz
Ventilation and cerebral blood flow (CBF) are both sensitive to hypoxia and hypercapnia. To compare chemosensitivity in these two systems, we made simultaneous measurements of ventilatory and cerebrovascular responses to hypoxia and hypercapnia in 35 normal human subjects before and after acclimatization to hypoxia. Ventilation and CBF were measured during stepwise changes in isocapnic hypoxia and iso-oxic hypercapnia. We used MRI to quantify actual cerebral perfusion. Measurements were repeated after 2-days of acclimatization to hypoxia at 3,800m altitude (PiO2 = 90 Torr) to compare plasticity in the chemosensitivity of these two systems...
July 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28705996/different-gene-response-to-mechanical-loading-during-early-and-late-phases-of-rat-achilles-tendon-healing
#6
Malin Hammerman, Parmis Blomgran, Arie Dansac, Pernilla Eliasson, Per Aspenberg
Mechanical loading stimulates tendon healing both when applied in the inflammatory phase and in the early remodeling phase of the process, although not necessarily via the same mechanisms. We investigated the gene response to mechanical loading in these two phases of tendon healing. The right Achilles tendon in rats was transected and the hind limbs were unloaded by tail suspension. The rats were exposed to 5 minutes of treadmill running 3 or 14 days after tendon transection. Thereafter, they were re-suspended for 15 minutes or 3 hours until euthanasia...
July 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28705995/reproducibility-of-airway-luminal-size-in-asthma-measured-by-hrct
#7
Robert H Brown, Robert J Henderson, Elizabeth A Sugar, Janet T Holbrook, Robert A Wise
High resolution computed tomography (HRCT) is a well-established imaging technology to measure lung and airway morphology in vivo. However, there is a surprising lack of studies examining HRCT reproducibility. The CPAP trial was a multicenter, randomized, 3-parallel arm, sham-controlled 12 week clinical trial to assess the use of a nocturnal CPAP device on airways reactivity to methacholine. The lack of a treatment effect of CPAP on clinical or HRCT measures provided an opportunity for the current analysis...
July 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28705994/wearable-brain-imaging-with-multi-modal-physiological-recording
#8
Gary E Strangman, Vladimir Ivkovic, Quan Zhang
The brain is a central component of cognitive and physical human performance. Measures including functional brain activation, cerebral perfusion, cerebral oxygenation, evoked electrical responses, and resting hemodynamic and electrical activity are all related to, or can predict health status or performance decrements. However, measuring brain physiology typically requires large, stationary machines that are not suitable for mobile or self-monitoring. Moreover, when individuals are ambulatory, systemic physiological fluctuations-e...
July 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28705993/effects-of-%C3%AE-hydroxy-%C3%AE-methylbutyrate-hmb-on-skeletal-muscle-mitochondrial-content-and-dynamics-and-lipids-after-10-days-of-bed-rest-in-older-adults
#9
Robert A Standley, Giovanna Distefano, Suzette L Pereira, Min Tian, Owen J Kelly, Paul M Coen, Nicolaas E P Deutz, Robert R Wolfe, Bret H Goodpaster
Loss of muscle mass during periods of disuse likely has negative health consequences for older adults. We have previously shown that β-hydroxy-β-methylbutyrate (HMB) supplementation during 10 days of strict bed rest (BR) attenuates the loss of lean mass in older adults. To elucidate potential molecular mechanisms of HMB effects on muscle during bed rest and resistance training rehabilitation (RT), we examined mediators of skeletal muscle mitochondrial dynamics, autophagy and atrophy, and intramyocellular lipids...
July 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28705992/beyond-just-hemoglobin-red-blood-cell-potentiation-of-hemoglobin-oxygen-unloading-in-fish
#10
Colin J Brauner, Till S Harter
Teleosts comprise 95% of fish species, and almost half of all vertebrate species, and represent one of the most successful adaptive radiation events among vertebrates. This is thought to be in part due to their unique oxygen (O2) transport system. In salmonids, recent in vitro and in vivo studies indicate that hemoglobin-oxygen (Hb-O2) unloading to tissues may be doubled or even tripled under some conditions without changes in perfusion. This is accomplished through the short-circuiting of red blood cell (RBC) pH regulation resulting in a large arterial-venous pH difference within the RBC and induced reduction in Hb-O2 affinity...
July 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28705991/oxygen-metabolism-and-innate-immune-responses-in-the-gut
#11
Sean Patrick Colgan, Eric L Campbell
Epithelial cells of the mucosa provide a first line of protection against the inappropriate flux of antigens from the outside world. In the gastrointestinal (GI) tract, this barrier is provided at a number of levels, including mucus production, epithelial junctional complexes and the production of antimicrobial molecules. In recent years, it is better appreciated that tissue oxygen metabolism is key to homeostasis in the mucosa. The intestine, for example, maintains a low baseline pO2 levels due to counter-current blood flow and the presence of large numbers of bacteria...
July 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28684598/reduced-collagen-accumulation-and-augmented-mmp-2-activity-in-left-ventricle-of-old-rats-submitted-to-high-intensity-resistance-training
#12
Vinicius Guzzoni, Rita C Marqueti, João Luiz Quagliotti Durigan, Hernandes F Carvalho, Rafael Lino, Marcelo S Mekaro, Tayná Dos Santos, Andre Souza Mecawi, Jose Antunes-Rodrigues, Jeffrey M Hord, Jonh M Lawler, Ana Paula Davel, Heloísa Sobreiro Selistre-de-Araujo
Progressive fibrosis is a hallmark of the aging heart. Age-related fibrosis is modulated by endurance exercise training; however, little is known concerning the influence of resistance training (RT). Therefore, we investigated the chronic effects of high-intensity RT on age-associated alterations of left ventricle (LV) structure, collagen content, matrix metalloproteinase-2 (MMP-2) and extracellular matrix-related gene expression, including transforming growth factor-β (TGF-β). Young adult (3 mo.) and aged (21 mo...
July 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28684597/dynamic-hyperinflation-and-exercise-limitations-in-obese-asthmatic-women
#13
Palmira Gabriele Ferreira, Patricia Duarte Freitas, Aline Grandi Silva, Desiderio Cano Porras, Rafael Stelmach, Alberto Cukier, Frederico Leon Arrabal Fernandes, Mílton A Martins, Celso R F Carvalho
Obese individuals and patients with asthma can develop dynamic hyperinflation (DH) during exercise; however, no previous study has investigated DH as a factor associated with reduced exercise capacity in obese asthmatic women. The aim of the present study was to examine the occurrence of DH and exercise limitations in obese asthmatics. Obese grade II (obese group (Ob-G); BMI 35-39.9 kg/m2; n=36) and non-obese (non-obese group (NOb-G); BMI 18.5-29.9 kg/m2; n=18) asthmatic patients performed a cardiopulmonary test to quantify peak VO2 and a submaximal exercise test to assess DH...
July 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28684596/rebuttal-from-billman
#14
George E Billman
N/A.
July 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28684595/rebuttal-from-boyett
#15
Mark R Boyett, Yanwen Wang, Shu Nakao, Jonathan Ariyaratnam, George Hart, Oliver Monfredi, Alicia D'Souza
N/A.
July 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28684594/counterpoint-exercise-training-induced-bradycardia-the-case-for-enhanced-parasympathetic-regulation
#16
https://www.readbyqxmd.com/read/28684593/point-exercise-training-induced-bradycardia-is-caused-by-changes-in-intrinsic-sinus-node-function
#17
Mark R Boyett, Yanwen Wang, Shu Nakao, Jonathan Ariyaratnam, George Hart, Oliver Monfredi, Alicia D'Souza
N/A.
July 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28684592/principles-insights-and-potential-pitfalls-of-the-non-invasive-determination-of-muscle-oxidative-capacity-by-near-infrared-spectroscopy
#18
Alessandra Adami, Harry B Rossiter
not requested for a Viewpoint.
July 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28684591/corp-improving-the-status-quo-for-measuring-whole-body-sweat-losses-wbsl
#19
Samuel N Cheuvront, Robert W Kenefick
The measurement of whole body sweat losses (WBSL) is important to the study of body heat balance, body water balance, establishing guidelines for water and electrolyte consumption, and the study of metabolism and health. In principal, WBSL is measured by an acute change in body mass (ΔBM) in response to a thermoregulatory sweating stimulus. In this CORP review, we re-visit several basic, but rarely discussed assumptions important to WBSL research, including the common equivalences: mass = weight = water = sweat...
July 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28684590/heat-acclimation-has-a-protective-effect-on-the-central-but-not-peripheral-nervous-system
#20
Sebastien Racinais, Mathew G Wilson, Nadia Gaoua, Julien D Périard
This study aimed to clarify the pathway mediating hyperthermia-induced alterations in neural drive transmission, and determine if heat acclimation protects voluntary muscle activation and cognitive function in hyperthermic humans. Electrically evoked potentials (H-reflex and M-wave), executive function (special planning and working memory) and maximal voluntary isometric contractions (120 s) were assessed in fourteen participants in control condition (CON, 24ºC, 40% RH) and hyperthermic states (HYP, 44-50ºC, 50% RH), on consecutive days in a counterbalanced order...
July 6, 2017: Journal of Applied Physiology
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