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Journal of Applied Physiology

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https://www.readbyqxmd.com/read/28336541/unilateral-nasal-obstruction-affects-motor-representation-development-within-the-face-primary-motor-cortex-in-growing-rats
#1
Yasunori Abe, Chiho Kato, Karin Harumi Uchima Koecklin, Hidemasa Okihara, Takayoshi Ishida, Koichi Fujita, Tadachika Yabushita, Satoshi Kokai, Takashi Ono
Postnatal growth is influenced by genetic and environmental factors. Nasal obstruction during growth alters the electromyographic activity of orofacial muscles. The facial primary motor area represents muscles of the tongue and jaw, which are essential in regulating orofacial motor functions, including chewing and jaw opening. This study aimed to evaluate the effect of chronic unilateral nasal obstruction during growth on the motor representations within the face primary motor cortex (M1). Seventy-two 6-day-old male Wistar rats were randomly divided into control (n = 36) and experimental (n = 36) groups...
March 23, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28336540/effects-of-midline-sagittal-location-on-bone-conducted-cervical-and-ocular-vestibular-evoked-myogenic-potentials
#2
Sendhil Govender, James Gordon Colebatch
We have investigated the effectiveness of two bone conducted stimuli in producing vestibular evoked myogenic potentials (VEMPs) following stimulation along mid-sagittal skull sites. Twenty subjects (mean age 24, range: 18 to 34 years; 6 males; 14 females) were studied using a smoothed impulse and a 500 Hz tone burst applied to Nz, Fpz, AFz, Fz, FCz and Cz with both compressive and rarefactive onset phases. Cervical (cVEMPs) and ocular VEMPs (oVEMPs) were recorded as well as linear acceleration in 3 axes. cVEMPs evoked by 500 Hz showed no change in response polarity to either stimulus location or phase...
March 23, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28336539/the-influence-of-gravity-on-regional-lung-blood-flow-in-humans-spect-in-the-upright-and-head-down-posture
#3
Malin Ax, Alejandro Sanchez-Crespo, Sten G E Lindahl, Margareta Mure, Johan Petersson
Previous studies in humans have shown that gravity has little influence on the distribution of lung blood flow while changing posture from supine to prone. This study aimed to evaluate the maximal influence of posture by comparison of regional lung blood flow in the upright and head-down posture in 8 healthy volunteers, using a tilt table. Regional lung blood flow was marked by i.v. injection of macroaggregates of human albumin labeled with (99m)Tc or (113m)In, in the upright and head-down posture respectively, during tidal breathing...
March 23, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28336538/effects-of-dobutamine-on-intestinal-microvascular-blood-flow-heterogeneity-and-oxygen-extraction-during-septic-shock
#4
Gustavo Adolfo Ospina-Tascón, Alberto Federico García Marín, Gabriel J Echeverri, William Fernando Bermúdez, Humberto José Madriñán Navia, Juan David Valencia, Edgardo Quiñones, Fernando Rodríguez, Angela Marulanda, César Augusto Arango Davila, Alejandro Bruhn, Glenn Hernández, Daniel De Backer
Derangements of microvascular blood flow distribution might contribute to disturbing oxygen extraction by peripheral tissues. We evaluated the dynamic relationships between the mesenteric oxygen extraction ratio (mes-ERO2) and the heterogeneity of microvascular blood flow at the gut and sublingual mucosa, during the development and resuscitation of septic shock in a swine model of fecal peritonitis. Jejunal-villi and sublingual microcirculation were evaluated using a portable intravital-microscopy technique...
March 23, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28336537/muscle-specific-and-age-related-changes-in-protein-synthesis-and-protein-degradation-in-response-to-hindlimb-unloading-in-rats
#5
Leslie M Baehr, Daniel W D West, Andrea G Marshall, George R Marcotte, Keith Baar, Sue C Bodine
Disuse is a potent inducer of muscle atrophy, but the molecular mechanisms driving this loss of muscle mass are highly debated. In particular, the extent to which disuse triggers decreases in protein synthesis or increases in protein degradation, and whether these changes are uniform across muscles or influenced by age is unclear. We aimed to determine the impact of disuse on protein synthesis and protein degradation in lower limb muscles of varied function and fiber type in adult and old rats. Alterations in protein synthesis and degradation were measured in the soleus, medial gastrocnemius (MG), and tibialis anterior (TA) muscles of adult and old rats subjected to hindlimb unloading (HU) for 3, 7 or 14 days...
March 23, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28336536/the-effect-of-aging-and-cardiorespiratory-fitness-on-the-lung-diffusing-capacity-response-to-exercise-in-healthy-humans
#6
Kirsten E Coffman, Alex R Carlson, Andrew D Miller, Bruce D Johnson, Bryan Joseph Taylor
Aging is associated with deterioration in the structure and function of the pulmonary circulation. We characterized the lung diffusing capacity for carbon monoxide (DLCO), alveolar-capillary membrane conductance (DmCO), and pulmonary-capillary blood volume (VC) response to discontinuous incremental exercise at 25, 50, 75, and 90% of peak work (Wpeak) in four groups: 1) Young [27 ± 3 y, maximal oxygen consumption (V̇O2max) 110 ± 18% age-predicted]; 2) Young Highly-Fit (27 ± 3 y, V̇O2max 147 ± 8% age-predicted); 3) Old (69 ± 5 y, V̇O2max 116 ± 13% age-predicted); and 4) Old Highly-Fit (65 ± 5 y, V̇O2max 162 ± 18% age-predicted)...
March 23, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28336535/the-effects-of-short-work-versus-longer-work-periods-within-intermittent-exercise-on-v%C3%AC-o2p-kinetics-muscle-deoxygenation-and-energy-system-contribution
#7
Michael Christopher McCrudden, Daniel A Keir, Glen R Belfry
We examined the effects of inserting 3 s recovery periods during high-intensity cycling exercise at 25 s and 10 s intervals on pulmonary oxygen uptake (V̇O2p), muscle deoxygenation (HHb), associated kinetics (τ), and energy system contributions. Eleven men (24±3 years) completed two trials of three cycling protocols: an 8 min continuous protocol (CONT) and two, 8 min intermittent exercise protocols with work-to-rest periods of 25 s-to-3 s (25INT) and 10 s-to-3 s (10INT). Each protocol began with a step-transition from a 20 W baseline to a power output (PO) of 60% between lactate threshold and maximal V̇O2p (Δ60)...
March 23, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28336534/muscle-length-dependent-contribution-of-motoneuron-cav1-3-channels-to-force-production-in-model-slow-motor-unit
#8
Hojeong Kim
Persistent inward current (PIC)-generating Cav1.3 channels in spinal motoneuron dendrites are thought to be actively recruited during normal behaviors. However, whether and how the activation of PIC channels influences force output of motor unit remains elusive. Here, building a physiologically realistic model of slow motor unit I demonstrate that force production induced by the PIC activation is much smaller for short than lengthened muscles during the regular firing of the motoneuron that transitioned from the quiescent state by either a brief current pulse at the soma or a brief synaptic excitation at the dendrites...
March 23, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28302709/acute-impact-of-conventional-and-eccentric-cycling-on-platelet-and-vascular-function-in-patients-with-chronic-heart-failure
#9
Andrew Haynes, Matthew D Linden, Lauren C Chasland, Kazunori Nosaka, Andrew J Maiorana, Ellen Adele Dawson, Lawrence Dembo, Louise H Naylor, Daniel J Green
Evidence-based guidelines recommend exercise therapy for patients with chronic heart failure (CHF). Such patients have increased atherothrombotic risk. Exercise can transiently increase platelet activation and reactivity and decrease vascular function in healthy participants, although data in CHF is scant. Eccentric (ECC) cycling is a novel exercise modality which may be particularly suited to patients with CHF, but the acute impacts of ECC on platelet and vascular function are currently unknown. Our null hypothesis was that ECC and concentric (CON) cycling, performed at matched external workloads, would not induce changes in platelet or vascular function in patients with CHF...
March 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28302708/thermoregulatory-responses-to-exercise-at-a-fixed-rate-of-heat-production-are-not-altered-by-acute-hypoxia
#10
Geoff B Coombs, Matthew N Cramer, Nicholas Ravanelli, Pascal Imbeault, Ollie Jay
This study sought to assess the within-subject influence of acute hypoxia on exercise-induced changes in core temperature and sweating. Eight participants [1.75 (0.06) m, 70.2 (6.8) kg, 25 (4) y, 54 (8) mL(.)kg(-1)(.)min(-1)] completed 45 min of cycling, once in normoxia (NORM; FiO2=0.21) and twice in hypoxia (HYP1/HYP2; FiO2=0.13) at 34.4(0.2)°C, 46(3)% RH. These trials were designed to elicit a) two distinctly different %VO2peak [NORM:45(8)% and HYP1:62(7)%] at the same heat production (Hprod) [NORM:6.7(0...
March 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28302707/neuropeptide-y3-36-incorporated-into-pvax-nanoparticle-improves-functional-blood-flow-in-a-murine-model-of-hind-limb-ischemia
#11
Derek Eshun, Rabya Saraf, Soochan Bae, Jelliffe Jeganathan, Feroze Mahmood, Serkan Dilmen, Qingen Ke, Dongwon Lee, Peter M Kang, Robina Matyal
We generated a novel nanoparticle called PVAX, which has intrinsic anti-apoptotic and anti-inflammatory properties. This nanoparticle was loaded with Neuropeptide Y3-36, an angiogenic neuro-hormone that plays a central role in angiogenesis. Subsequently, we investigated whether PVAX-NPY3-36 could act as a therapeutic agent and induce angiogenesis and vascular remodeling in a murine model of hind limb ischemia. Adult C57BL/J6 mice (n=40) were assigned to treatment groups: Control, Ischemia PBS, Ischemia PVAX, Ischemia NPY3-36, and Ischemia PVAX-NPY3-36 Ischemia was induced by ligation of the femoral artery in all groups except Control and given relevant treatments (PBS, PVAX, NPY3-36, and PVAX-NPY3-36)...
March 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28302706/acclimatization-of-the-systemic-microcirculation-to-alveolar-hypoxia-is-mediated-by-inos-dependent-increased-nitric-oxide-availability
#12
Alfred J Casillan, Jie Chao, John G Wood, Norberto C Gonzalez
Rats breathing 10% O2 show a rapid and widespread systemic microvascular inflammation that results from nitric oxide (NO) depletion secondary to increased reactive O2 species (ROS) generation. The inflammation eventually resolves and the microcirculation becomes resistant to more severe hypoxia. These experiments were directed to determine the mechanisms underlying this microvascular acclimatization process. Intravital microscopy of the mesentery showed that after three weeks of hypoxia (PB ~380 Torr, inspired PO2 ~ 68-70 Torr) rats showed no evidence of inflammation; however, treatment with the inducible NO synthase (iNOS) inhibitor L-N(6)-(1-Iminoethyl) lysine dihydrochloride (L-NIL) led to ROS generation, leukocyte-endothelial adherence and emigration, and increased vascular permeability...
March 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28302705/brown-and-beige-adipose-tissues-phenotype-and-metabolic-potential-in-mice-and-men
#13
Kanta Chechi, Wouter David van Marken Lichtenbelt, Denis Richard
With the recent re-discovery of brown fat in adult humans, our outlook on adipose tissue biology has undergone a paradigm shift. While we attempt to identify, recruit and activate classic brown fat stores in humans, identification of beige/brite adipocytes has also raised the possibility of browning our white fat stores. Whether such transformation of human white fat depots can be achieved in order to enhance the whole-body oxidative potential remains to be seen. Evidence to-date, however, largely points towards a major oxidative role only for classic brown fat depots in rodents and in humans (e...
March 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28302704/swimming-attenuates-d-galactose-induced-brain-aging-via-suppressing-mir-34a-mediated-autophagy-impairment-and-abnormal-mitochondrial-dynamics
#14
Xianjuan Kou, Jie Li, Xingran Liu, Jingru Chang, Qingxia Zhao, Shaohui Jia, Jingjing Fan, Ning Chen
MicroRNAs (miRNAs) have been reported to be involved in many neurodegenerative diseases. In order to explore the regulatory role of miR-34a in aging-related diseases such as Alzheimer's disease (AD) during exercise intervention, we constructed a rat model with (D-galactose) D-gal-induced oxidative stress and cognitive impairment coupled with dysfunctional autophagy and abnormal mitochondrial dynamics, determined the mitigation of cognitive impairment of D-gal-induced aging rats during swimming intervention, and evaluated miR-34a-mediated functional status of autophagy and abnormal mitochondrial dynamics...
March 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28280109/exercise-induced-dehydration-alters-pulmonary-function-but-does-not-modify-airway-responsiveness-to-dry-air-in-athletes-with-mild-asthma
#15
Andrew J Simpson, Lee M Romer, Pascale Kippelen
BACKGROUND: Local airway water loss is the main physiological trigger for exercise-induced bronchoconstriction (EIB). AIM: To investigate the effects of whole-body water loss on airway responsiveness and pulmonary function in athletes with mild asthma and/or EIB. METHODS: Ten recreational athletes with a doctor diagnosis of mild asthma and/or EIB completed a randomized, cross-over study. Pulmonary function tests (spirometry, whole-body plethysmography and diffusing capacity for carbon monoxide [DLCO]) were conducted before and after three conditions: i) 2 h exercise in the heat with no fluid intake (dehydration); ii) 2 h exercise with ad libitum fluid intake (control); and iii) time-matched rest period (rest)...
March 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28280108/moderate-and-intense-muscular-exercises-induce-marked-intramyocellular-metabolic-acidosis-in-sickle-cell-disease-mice
#16
Benjamin Chatel, Laurent André Messonnier, Christophe Hourdé, Christophe Vilmen, Monique Bernard, David Bendahan
Sickle cell disease (SCD) is associated with an impaired oxygen delivery to skeletal muscle that could alter ATP production processes. The present study aimed to determine the effects of sickle hemoglobin (HbS) on muscle pH homeostasis in response to exercise in homozygous (HbSS, n = 9) and heterozygous (HbAS, n = 10) SCD (Townes) mice in comparison to control (HbAA, n = 10) littermates. Magnetic resonance spectroscopy of phosphorus 31 enabled to measure intramuscular pH (pHi) and phosphocreatine (PCr) concentration during rest-stimulation-recovery protocols at two different intensities...
March 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28280107/ventilation-heterogeneity-measured-by-multiple-breath-inert-gas-testing-is-not-affected-by-inspired-oxygen-concentration-in-healthy-humans
#17
Susan Roberta Hopkins, Ann R Elliott, Gordon Kim Prisk, Chantal Darquenne
Multiple breath washout (MBW) and oxygen-enhanced MRI techniques use acute exposure to 100% oxygen to measure ventilation heterogeneity. Implicit is the assumption that breathing 100% oxygen does not induce changes in ventilation heterogeneity, however, this is untested. We hypothesized that ventilation heterogeneity decreases with increasing inspired oxygen concentration in healthy subjects. We performed MBW in 8 healthy subjects (4 female, 4 male, Age=43±15y) with normal pulmonary function (FEV1=98±6% predicted) using 10% Argon as a tracer gas and oxygen concentrations of 12...
March 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28280106/dynamics-of-middle-cerebral-artery-blood-flow-velocity-during-moderate-intensity-exercise
#18
Sandra A Billinger, Jesse C Craig, Sarah J Kwapiszeski, Jason-Flor Villarosa Sisante, Eric Dennis Vidoni, Rebecca Maletsky, David C Poole
The dynamic response to a stimulus such as exercise can reveal valuable insights into systems control in health and disease that is not evident from the steady-state perturbation. However, the dynamic response profile and kinetics of cerebrovascular function have not been determined to date. We tested the hypotheses that bilateral middle cerebral artery blood flow velocity (MCAV) increases exponentially following the onset of moderate intensity exercise in ten healthy young subjects. The MCAV response profiles were well fit to a delay (TD) + exponential (time constant, τ) model with substantial agreement for baseline (L: 69, R: 64 cm·s(-1), coefficient of variation, c...
March 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28280105/measurement-of-the-distribution-of-ventilation-perfusion-ratios-in-the-human-lung-with-proton-mri-comparison-with-the-multiple-inert-gas-elimination-technique
#19
Rui Carlos Sá, Angela Cortney Henderson, Tatum S Simonson, Tatsuya J Arai, Harrieth Wagner, Rebecca J Theilmann, Peter D Wagner, Gordon Kim Prisk, Susan Roberta Hopkins
We have developed a novel functional proton magnetic resonance imaging (MRI) technique to measure regional ventilation-perfusion (VA/Q ) ratio in the lung. We conducted a comparison study of this technique in healthy subjects (n=7, age=42±16, Forced expiratory volume in 1 second=94% predicted), by comparing data measured using MRI to that obtained from the multiple inert gas elimination technique (MIGET). Regional ventilation measured in a sagittal lung slice using Specific Ventilation Imaging was combined with proton density measured using a fast gradient-echo sequence to calculate regional alveolar ventilation, registered with perfusion images acquired using arterial spin labeling, and divided on a voxel-by-voxel basis to obtain regional VA/Q ratio...
March 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28255089/anthropometric-prediction-of-skeletal-muscle-cross-sectional-area-in-persons-with-spinal-cord-injury
#20
Rodney C Wade, Ashraf S Gorgey
Finding an accurate and affordable method to quantify muscle size following spinal cord injury (SCI) could provide benefits clinically and in research settings. The purpose of this study was to validate the use of anthropometric measurements versus magnetic resonance imaging (MRI) to evaluate muscle cross-sectional area (CSA) and develop a field equation to predict muscle CSA specific to the SCI population. Twenty-two men with chronic (>1yr) motor complete SCI participated in the current study. Anthropometric measurements, including mid-thigh circumference and anterior skinfold thickness (SFT), were taken on the right thigh...
March 2, 2017: Journal of Applied Physiology
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