Late Toxicity and Patient Satisfaction in Hypofractionated Post-Mastectomy Radiotherapy after Immediate-Autologous Reconstruction.

PURPOSE/OBJECTIVE(S): Immediate autologous reconstruction (IAR) is increasingly being used in the context of breast cancer patients (BCP) treated with mastectomy with the need for subsequent radiotherapy treatment. Currently in clinical practice, despite the fact that conventional fractionated RT (CFRT) has been the standard schedule, hypofractionation schemes are becoming increasingly common. Although no results have been reported on tolerance, late toxicity and satisfaction with treatment in this setting. Our aim was to evaluate late side-effects and patient´s satisfaction receiving PMRT after IAR, comparing CFRT vs HFRT.

MATERIALS/METHODS: Between June 2015 and February 2020, 47 patients received either CF or HF PMRT after IAR in a tertiary hospital. IAR was performed with latissimus dorsi (LD) or deep inferior epigastric perforator (DIEP) flaps at the time of mastectomy. The prescribed dose was 50 Gy over 25 fractions in the CF schedule and 40.05 Gy over 15 fractions in the HF schedule. The target volume to be treated was the reconstructed chest-wall and the axillary-supraclavicular nodes if indicated, using intensity-modulated radiotherapy treatment technique. Late toxicity was evaluated using CTCAE v.5.0 criteria, and patient´s global satisfaction was assessed using a self-evaluation questionnaire, in which patients answered a series of selected questions related to radiation therapy from the BREAST-Q questionnaire, from 1-5 points.

RESULTS: Median age was 48 years (28-77) and median follow-up was 51 months (27-99). 25 patients received HFRT and 22 CFRT. Late side effects after PMRT and tolerance until 3 years with both schedules are shown in Table 1. No relationship was found between incidence of late side effects and RT fractionation. Mean patient´s satisfaction was 3.8 in the CFRT schedule and 4 in the HFRT schedule.

CONCLUSION: According to our findings, HFRT after IAR in post-mastectomy setting seems to be safe and well tolerated, with no high rates of severe late toxicity and with a good level of satisfaction of the treated patients. Table 1. Three years side effects of CRFT and HFRT radiotherapy after mastectomy and immediate autologous reconstruction in 47 patients.