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International Journal of Radiation Oncology, Biology, Physics

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https://www.readbyqxmd.com/read/28209443/continued-benefit-to-rectal-separation-for-prostate-radiation-therapy-final-results-of%C3%A2-a%C3%A2-phase-iii-trial
#1
Daniel A Hamstra, Neil Mariados, John Sylvester, Dhiren Shah, Lawrence Karsh, Richard Hudes, David Beyer, Steven Kurtzman, Jeffrey Bogart, R Alex Hsi, Michael Kos, Rodney Ellis, Mark Logsdon, Shawn Zimberg, Kevin Forsythe, Hong Zhang, Edward Soffen, Patrick Francke, Constantine Mantz, Peter Rossi, Theodore DeWeese, Stephanie Daignault-Newton, Benjamin W Fischer-Valuck, Anupama Chundury, Hiram Gay, Walter Bosch, Jeff Michalski
PURPOSE: SpaceOAR, a Food and Drug Administration-approved hydrogel intended to create a rectal-prostate space, was evaluated in a single-blind phase III trial of image guided intensity modulated radiation therapy. A total of 222 men were randomized 2:1 to the spacer or control group and received 79.2 Gy in 1.8-Gy fractions to the prostate with or without the seminal vesicles. The present study reports the final results with a median follow-up period of 3 years. METHODS AND MATERIALS: Cumulative (Common Terminology Criteria for Adverse Events, version 4...
December 23, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28126312/in-regard-to-pan-et%C3%A2-al-and-falit-et%C3%A2-al
#2
LETTER
John Leung
No abstract text is available yet for this article.
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28126311/in-reply-to-mazeron-et%C3%A2-al
#3
LETTER
Cameron W Swanick, Patricia J Eifel, Ann H Klopp
No abstract text is available yet for this article.
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28126310/in-regard-to-swanick-et%C3%A2-al
#4
LETTER
Renaud Mazeron, Eleonor Rivin Del Campo, Christine Haie-Meder, Cyrus Chargari
No abstract text is available yet for this article.
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28126309/smart-radiation-therapy-biomaterials
#5
REVIEW
Wilfred Ngwa, Francis Boateng, Rajiv Kumar, Darrell J Irvine, Silvia Formenti, Twalib Ngoma, Carsten Herskind, Marlon R Veldwijk, Georg Lars Hildenbrand, Michael Hausmann, Frederik Wenz, Juergen Hesser
Radiation therapy (RT) is a crucial component of cancer care, used in the treatment of over 50% of cancer patients. Patients undergoing image guided RT or brachytherapy routinely have inert RT biomaterials implanted into their tumors. The single function of these RT biomaterials is to ensure geometric accuracy during treatment. Recent studies have proposed that the inert biomaterials could be upgraded to "smart" RT biomaterials, designed to do more than 1 function. Such smart biomaterials include next-generation fiducial markers, brachytherapy spacers, and balloon applicators, designed to respond to stimuli and perform additional desirable functions like controlled delivery of therapy-enhancing payloads directly into the tumor subvolume while minimizing normal tissue toxicities...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28126308/large-scale-retrospective-monte-carlo-dosimetric-study-for-permanent-implant-prostate-brachytherapy
#6
Nelson Miksys, Eric Vigneault, Andre-Guy Martin, Luc Beaulieu, Rowan M Thomson
PURPOSE: To retrospectively compare water-based and full tissue model Monte Carlo dose calculations in a large cohort of patients undergoing (125)I permanent implant prostate brachytherapy. METHODS AND MATERIALS: For 613 patients, EGSnrc BrachyDose dose calculations were performed in 2 virtual patient models: TG43sim (simulated American Association of Physicists in Medicine Task Group Report 43 conditions) and MCref (computed tomography-derived heterogeneous tissue model with interseed effects)...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28126307/molecular-contrast-enhanced-ultrasound-imaging-of-radiation-induced-p-selectin-expression-in-healthy-mice-colon
#7
Ahmed El Kaffas, Kevin Smith, Pooja Pradhan, Steven Machtaler, Huaijun Wang, Rie von Eyben, Jürgen K Willmann, Dimitre Hristov
PURPOSE: To evaluate the feasibility of using molecular contrast-enhanced ultrasound (mCEUS) to image radiation (XRT)-induced expression of cell adhesion molecules that mediate inflammatory response to XRT in healthy mouse colon tissue. METHODS AND MATERIALS: The colons of male BALB/c mice (aged 6-8 weeks, n=9) were irradiated with 14 Gy using a Kimtron IC-225 x-ray irradiator operating at 225 kV/13.0 mA at a dose rate of 0.985 Gy/min. The head and thorax regions were shielded during irradiation...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28126306/the-impact-of-radiation-oncologists-on-the-early-adoption-of-hypofractionated-radiation-therapy-for-early-stage-breast-cancer
#8
Isabel J Boero, Erin F Gillespie, Jiayi Hou, Anthony J Paravati, Ellen Kim, John P Einck, Catheryn Yashar, Loren K Mell, James D Murphy
PURPOSE: Despite multiple randomized trials showing the efficacy of hypofractionated radiation therapy in early-stage breast cancer, the United States has been slow to adopt this treatment. The goal of this study was to evaluate the impact of individual radiation oncologists on the early adoption of hypofractionated radiation therapy for early-stage breast cancer. METHODS: We identified 22,233 Medicare beneficiaries with localized breast cancer that was diagnosed from 2004 to 2011 who underwent breast-conserving surgery with adjuvant radiation...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28126305/hypofractionated-regional-nodal-irradiation-for-women-with-node-positive-breast-cancer
#9
Sara Bellefqih, Sanaa Elmajjaoui, Jihan Aarab, Jihane Khalil, Mohamed Afif, Amine Lachgar, Hanan El Kacemi, Tayeb Kebdani, Noureddine Benjaafar
PURPOSE: To evaluate the effect of hypofractionated radiation therapy (HFRT) of the breast/chest wall and regional nodes on overall survival (OS), disease-free survival (DFS), locoregional control and on treatment-related toxicity in patients with breast cancer and nodal involvement. METHODS AND MATERIALS: Two hundred fifty-seven patients treated between October 2009 and June 2011 with hypofractionated locoregional radiation therapy (42 Gy in 15 fractions) were retrospectively reviewed, 51 (19...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28126304/significance-of-co-expression-of-epidermal-growth-factor-receptor-and-ki67-on-clinical-outcome-in-patients-with-anal-cancer-treated-with-chemoradiotherapy-an-analysis-of-nrg-oncology-rtog-9811
#10
Corinne M Doll, Jennifer Moughan, Alexander Klimowicz, Clement K Ho, Elizabeth N Kornaga, Susan P Lees-Miller, Jaffer A Ajani, Christopher H Crane, Lisa A Kachnic, Gordon S Okawara, Lawrence B Berk, Kevin S Roof, Mark J Becker, David L Grisell, Robert J Ellis, Paul W Sperduto, Gerald W Marsa, Chandan Guha, Anthony M Magliocco
PURPOSE: To measure co-expression of EGFR and Ki67 proteins in pretreatment tumor biopsies of anal cancer patients enrolled on NRG Oncology RTOG 9811, a phase III trial comparing 5-fluorouracil/mitomycin-C/radiation therapy (Arm A) versus 5-fluorouracil/cisplatin/radiation therapy (Arm B), and to correlate expression with clinical outcome. METHODS AND MATERIALS: EGFR and Ki67 co-expression was measured after constructing a tissue microarray using fluorescence immunohistochemistry and automated quantitative image analysis...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28126303/bone-marrow-sparing-intensity-modulated-radiation-therapy-with-concurrent-cisplatin-for-stage-ib-iva-cervical-cancer-an-international-multicenter-phase-ii-clinical-trial-intertecc-2
#11
Loren K Mell, Igor Sirák, Lichun Wei, Rafal Tarnawski, Umesh Mahantshetty, Catheryn M Yashar, Michael T McHale, Ronghui Xu, Gordon Honerkamp-Smith, Ruben Carmona, Mary Wright, Casey W Williamson, Linda Kasaová, Nan Li, Stephen Kry, Jeff Michalski, Walter Bosch, William Straube, Julie Schwarz, Jessica Lowenstein, Steve B Jiang, Cheryl C Saenz, Steve Plaxe, John Einck, Chonlakiet Khorprasert, Paul Koonings, Terry Harrison, Mei Shi, A J Mundt
PURPOSE: To test the hypothesis that intensity modulated radiation therapy (IMRT) reduces acute hematologic and gastrointestinal (GI) toxicity for patients with locoregionally advanced cervical cancer. METHODS AND MATERIALS: We enrolled patients with stage IB-IVA cervical carcinoma in a single-arm phase II trial involving 8 centers internationally. All patients received weekly cisplatin concurrently with once-daily IMRT, followed by intracavitary brachytherapy, as indicated...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28126302/patterns-of-recurrence-after-postprostatectomy-fossa-radiation-therapy-identified-by-c-11-choline-positron-emission-tomography-computed-tomography
#12
William P Parker, Jaden D Evans, Bradley J Stish, Sean S Park, Kenneth Olivier, Richard Choo, Mark A Nathan, Brian T Welch, R Jeffrey Karnes, Lance A Mynderse, Thomas M Pisansky, Eugene D Kwon, Val J Lowe, Brian J Davis
PURPOSE: To evaluate C-11 choline positron emission tomography/computed tomography (CholPET) in staging and determining patterns of recurrence in prostate cancer patients with rising prostate-specific antigen levels after prostatectomy radiation therapy (RT). METHODS AND MATERIALS: The study includes patients with biochemical failure after postprostatectomy RT who underwent CholPET between 2008 and 2015. Patient and disease characteristics were examined in relation to sites of recurrence...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28126301/exploring-value-from-the-patient-s-perspective-between-modern-radiation-therapy-modalities-for-localized-prostate-cancer
#13
Narek Shaverdian, Darlene Verruttipong, Pin-Chieh Wang, Amar U Kishan, D Jeffrey Demanes, Susan McCloskey, Patrick Kupelian, Michael L Steinberg, Christopher R King
PURPOSE: Patients' perspectives on their treatment experiences have not been compared between modern radiation modalities for localized prostate cancer. We evaluated treatment regret and patients' perceptions of their treatment experiences to better inform our understanding of a treatment's value. METHODS AND MATERIALS: Patients with localized prostate cancer treated with stereotactic body radiation therapy (SBRT), intensity modulated radiation therapy (IMRT), or high-dose-rate (HDR) brachytherapy between 2008 and 2014 with at least 1 year of follow-up were surveyed...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28126300/effect-of-long-term-hormonal-therapy-vs-short-term-hormonal-therapy-a-secondary-analysis-of-intermediate-risk-prostate-cancer-patients-treated-on-nrg-oncology-rtog-9202
#14
Amin J Mirhadi, Qiang Zhang, Gerald E Hanks, Herbert Lepor, David J Grignon, Christopher A Peters, Seth A Rosenthal, Kenneth Zeitzer, John S Radwan, Colleen Lawton, Matthew B Parliament, Robert S Reznik, Howard M Sandler
PURPOSE: NRG Oncology RTOG 9202 was a randomized trial testing long-term adjuvant androgen deprivation (LTAD) versus initial androgen deprivation only (STAD) with external beam radiation therapy (RT) in mostly high-risk and some intermediate-risk prostate cancer patients. RTOG 9408 found an overall survival (OS) advantage in patients with cT1b-T2b disease and prostate-specific antigen (PSA) <20 ng/mL, with benefit observed mostly among intermediate-risk patients. It was still unknown whether intermediate-risk patients would experience an additional survival benefit with LTAD; thus, we performed a secondary analysis to explore whether LTAD had any incremental benefit beyond STAD among the intermediate-risk subset of RTOG 9202...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28126299/acute-and-late-adverse-events-associated-with-radical-radiation-therapy-prostate-cancer-treatment-a-systematic-review-of-clinician-and-patient-toxicity-reporting-in-randomized-controlled-trials
#15
REVIEW
Patricia Holch, Ann M Henry, Susan Davidson, Alexandra Gilbert, Jacqueline Routledge, Leanne Shearsmith, Kevin Franks, Emma Ingleson, Abigail Albutt, Galina Velikova
PURPOSE: This review aimed to determine the clinician and patient reported outcome (PRO) instruments currently usedin randomized controlled trials (RCTs) of radical radiation therapy for nonmetastatic prostate cancer to report acute and late adverse events (AEs), review the quality of methodology and PRO reporting, and report the prevalence of acute and late AEs. METHODS AND MATERIALS: The MEDLINE, EMBASE, and Cochrane databases were searched between April and August 2014 according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28126298/hyperbaric-oxygen-as-radiation-sensitizer-for-locally-advanced-squamous-cell-carcinoma-of-the-oropharynx-a-phase-1-dose-escalation-study
#16
Alan C Hartford, Thomas H Davis, Jay C Buckey, Robert L Foote, Mark S Sinesi, Benjamin B Williams, Anna K Fariss, Philip E Schaner, Paul L Claus, Scott H Okuno, James R Hussey, Richard E Clarke
PURPOSE: To explore, in a dose-escalation study, the feasibility of hyperbaric oxygen (HBO) treatments immediately before intensity modulated radiation therapy in conjunction with cisplatinum chemotherapy for squamous cell carcinoma of the head and neck (SCCHN). METHODS AND MATERIALS: Eligible patients presented with SCCHN (stage III-IV [M0]), life expectancy >6 months, and Karnofsky performance status ≥70. Enrollees received intensity modulated radiation therapy, 70 Gy in 35 fractions over 7 weeks with weekly cisplatinum...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28126297/chemotherapy-first-then-select-for-local-therapy
#17
LETTER
Benjamin D Smith
No abstract text is available yet for this article.
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28126296/ablative-therapy-a-reasonable-approach
#18
LETTER
Asal Rahimi, Robert Timmerman
No abstract text is available yet for this article.
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28126295/oligometastasis-directed-ablative-therapy-a-clinical-trial-question
#19
LETTER
James M Melotek, Steven J Chmura
No abstract text is available yet for this article.
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28126294/internal-mammary-misfortune
#20
EDITORIAL
Penny Fang
No abstract text is available yet for this article.
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
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