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International Journal of Radiation Oncology, Biology, Physics

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https://www.readbyqxmd.com/read/28454734/conservative-treatments-of-ocular-melanomas-technology-used-wisely-a-response-to-yazici-et%C3%A2-al
#1
EDITORIAL
Juliette Thariat, Joel Herault, Frederic Mouriaux
No abstract text is available yet for this article.
April 25, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28602420/toward-personalized-cancer-care-for-elderly-head-and-neck-cancer-patients
#2
LETTER
Ester Orlandi, Paolo Bossi
No abstract text is available yet for this article.
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28602419/-but-we-are-already-geriatric-oncologists-why-older-patients-need-a-special-approach-a-view-from-a-united-kingdom-cancer-center
#3
LETTER
Anthea Cree, Tania Hawthorn, Laura Pemberton, Richard Cowan, Ananya Choudhury
No abstract text is available yet for this article.
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28602418/use-of-stereotactic-radiosurgery-in-elderly-and-very-elderly-patients-with-brain-metastases-to-limit-toxicity-associated-with-whole-brain-radiation-therapy
#4
Linda Chen, Colette Shen, Kristin J Redmond, Brandi R Page, Megan Kummerlowe, Todd Mcnutt, Chetan Bettegowda, Daniele Rigamonti, Michael Lim, Lawrence Kleinberg
PURPOSE: We evaluated the toxicity associated with stereotactic radiosurgery (SRS) and whole brain radiation therapy (WBRT) in elderly and very elderly patients with brain metastases, as the role of SRS in geriatric patients who would traditionally receive WBRT is unclear. METHODS AND MATERIALS: We conducted a retrospective review of elderly patients (aged 70-79 years) and very elderly patients (aged ≥80 years) with brain metastases who underwent RT from 2010 to 2015 at Johns Hopkins Hospital...
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28602417/survival-outcomes-with-short-course-radiation-therapy-in-elderly-patients-with-glioblastoma-data-from-a-randomized-phase-3-trial
#5
Douglas Guedes de Castro, Juliana Matiello, Wilson Roa, Sunita Ghosh, Lucyna Kepka, Narendra Kumar, Valery Sinaika, Darejan Lomidze, Dalenda Hentati, Eduardo Rosenblatt, Elena Fidarova
PURPOSE: To perform a subset analysis of survival outcomes in elderly patients with glioblastoma from a randomized phase 3 trial comparing 2 short-course radiation therapy (RT) regimens in elderly and/or frail patients. METHODS AND MATERIALS: The original trial population included elderly and/or frail patients with a diagnosis of glioblastoma. Patients joined the phase 3, randomized, multicenter, prospective, noninferiority trial; were assigned to 1 of 2 groups in a 1:1 ratio, either short-course RT (25 Gy in 5 fractions, arm 1) or commonly used RT (40 Gy in 15 fractions, arm 2); and were stratified by age (<65 years and ≥65 years), Karnofsky Performance Status (KPS), and extent of surgery...
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28602416/breaking-up-is-hard-to-do-omission-of-radiation-therapy-for-select-women-aged-70%C3%A2-years-with-breast-cancer
#6
EDITORIAL
Jeffrey Peppercorn, Rachel Jimenez
No abstract text is available yet for this article.
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28602415/evaluation-of-treatment-candidacy-in-older-adults-with-cancer
#7
Joe C Huang, Upendra Parvathaneni
No abstract text is available yet for this article.
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28602414/the-older-adult-with-locoregionally-advanced-head-and-neck-squamous-cell-carcinoma-knowledge-gaps-and-future-direction-in-assessment-and-treatment
#8
Ronald Maggiore, Zachary S Zumsteg, Karlynn BrintzenhofeSzoc, Kelly M Trevino, Ajeet Gajra, Beatriz Korc-Grodzicki, Joel B Epstein, Stewart M Bond, Ira Parker, Julie A Kish, Barbara A Murphy, Noam A VanderWalde
Older adults with head and neck squamous cell carcinoma (HNSCC) pose unique treatment and supportive care challenges to oncologists and other cancer care providers. The majority of patients with HNSCC present with locoregionally advanced disease, for which combined-modality treatment integrating chemotherapy and radiation therapy is often necessary to maximize tumor control. However, applying these approaches to an older population with concomitant comorbidities and a higher risk of functional impairments remains challenging and is exacerbated by the paucity of studies involving older adults...
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28602413/the-use-of-hormone-therapy-alone-versus-hormone-therapy-and-radiation-therapy-for-breast-cancer-in-elderly-women-a-population-based-study
#9
Alan M Nichol, Elisa K Chan, Sarah Lucas, Sally L Smith, Lovedeep Gondara, Caroline Speers, Scott Tyldesley
PURPOSE: The Cancer and Leukemia Group B (CALGB) 9343 trial randomized elderly women with estrogen receptor-positive, stage 1 breast cancer to receive either hormone therapy (HT) or HT and radiation therapy (HT-RT) after lumpectomy and showed no difference in survival. After this publication, a practice guideline made HT alone a standard treatment option in British Columbia. The subsequent population-based pattern of practice was studied. METHODS AND MATERIALS: All women aged 70 to 79 years, referred after lumpectomy from 1999 to 2009, with stage 1, estrogen receptor-positive breast cancer were identified...
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28602412/definitive-chemoradiation-therapy-for-esophageal-cancer-in-the-elderly-clinical-outcomes-for-patients-exceeding-80%C3%A2-years-old
#10
Cai Xu, Mian Xi, Amy Moreno, Yutaka Shiraishi, Brian P Hobbs, Meilin Huang, Ritsuko Komaki, Steven H Lin
PURPOSE: The optimal treatment approach for patients ≥80 years ("elderly") with esophageal cancer is not well established. We assessed the clinical outcomes in elderly patients treated with definitive chemoradiation therapy (CCRT) at our institution. METHODS AND MATERIALS: 56 consecutive patients ≥80 years with esophageal cancer treated with conventional CCRT between 2001 and 2016 were propensity score matched 1:2 to generate 2 younger patient cohorts treated with CCRT without surgery: "intermediate" (65-79 years, n=112) and "younger" (<65 years, n=112)...
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28602411/survival-outcomes-of-elderly-patients-with-glioblastoma-multiforme-in-their-75th-year-or-older-treated-with-adjuvant-therapy
#11
Georgia Harris, Dasantha Jayamanne, Helen Wheeler, Cecelia Gzell, Marina Kastelan, Geoff Schembri, David Brazier, Raymond Cook, Jonathan Parkinson, Mustafa Khasraw, Sandra Louw, Michael Back
PURPOSE: To assess the outcomes of the most elderly cohort of patients with a diagnosis of glioblastoma multiforme (GBM) after intensity modulated radiation therapy (IMRT). METHODS AND MATERIALS: The data of patients with GBM who had underwent IMRT from May 2007 to December 2015 were entered into a prospective database. Analysis was performed on the data from patients diagnosed during or after 75 years of age. The primary endpoint was the median survival. Univariate and multivariate analyses were performed with respect to survival for patients aged 74 to 80 versus >80 years, Eastern Cooperative Oncology Group performance status of 0 to 1 versus 2 to 3, extent of resection, a high radiation dose (60 Gy) versus any hypofractionated schedule, MGMT methylation status, planning target volume, and the use of temozolomide (TMZ) versus no TMZ...
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28602410/adjuvant-chemoradiation-after-surgical-resection-in-elderly-patients-with-high-risk-squamous-cell-carcinoma-of-the-head-and-neck-a-national-cancer-database-analysis
#12
Neil M Woody, Matthew C Ward, Shlomo A Koyfman, Chandana A Reddy, Jessica Geiger, Nikhil Joshi, Brian Burkey, Joseph Scharpf, Eric Lamarre, Brandon Prendes, David J Adelstein
PURPOSE: To determine the patterns of adjuvant chemoradiotherapy use in elderly patients treated with definitive surgical resection for squamous cell carcinoma of the head and neck with extracapsular extension (ECE) or positive margins and determine whether an association with overall survival (OS) exists with adjuvant concurrent chemoradiotherapy (CRT). METHODS AND MATERIALS: The National Cancer Database was queried to identify patients with SCC of the oral cavity, oropharynx, larynx, and hypopharynx who were treated with primary definitive surgery and adjuvant radiation therapy between 2004 and 2012...
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28602409/clinical-outcomes-in-elderly-patients-treated-for-oral-cavity-squamous-cell-carcinoma
#13
Jie Jane Chen, Jennifer L Shah, Jeremy P Harris, Timothy T Bui, Kurt Schaberg, Christina S Kong, Michael J Kaplan, Vasu Divi, David Schoppy, Quynh-Thu Le, Wendy Y Hara
PURPOSE: Oral cavity squamous cell carcinoma (OCSCC) commonly occurs in elderly patients. This study explores the clinical outcomes in elderly patients with OCSCC based on their functional status and clinical comorbidities. METHODS AND MATERIALS: We retrospectively reviewed 180 patients aged ≥70 who were treated with definitive intent with surgery followed by adjuvant therapy if indicated for newly diagnosed OCSCC from 1998 to 2013. Pathology review was conducted, and Eastern Cooperative Oncology Group (ECOG) performance status and the Head and Neck Charlson Comorbidity Index (HN-CCI) were assessed...
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28602408/communicating-effectively-with-elderly-cancer-patients
#14
Mohamad H Fakhreddine, Eva Galvan, Jamie Pawlowski, William E Jones
No abstract text is available yet for this article.
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28602407/improving-consistency-and-quality-of-care-for-older-adults-with-cancer-the-challenges-of-developing-consensus-guidelines-for-radiation-therapy
#15
EDITORIAL
Noam VanderWalde, Arti Hurria, Reshma Jagsi
No abstract text is available yet for this article.
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28602406/cancer-in-the-elderly-moving-the-needle-toward-evidence-based-personalized-oncology
#16
EDITORIAL
Martine Extermann
No abstract text is available yet for this article.
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28602405/radiation-therapy-in-elderly-persons-an-old-issue-with-new-approaches
#17
EDITORIAL
Benjamin Movsas
No abstract text is available yet for this article.
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28602404/frailty-is-our-destiny-an-introduction-to-the-red-journal-s-special-edition-on-radiation-therapy-in-the-elderly
#18
EDITORIAL
Anthony L Zietman
No abstract text is available yet for this article.
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28476434/survival-patterns-in-elderly-head-and-neck-squamous-cell-carcinoma-patients-treated-with-definitive-radiation-therapy
#19
Linda W Sommers, Roel J H M Steenbakkers, Henk P Bijl, Johanna G M Vemer-van den Hoek, Jan L N Roodenburg, Sjoukje F Oosting, Gyorgy B Halmos, Sophia E de Rooij, Johannes A Langendijk
PURPOSE: We sought to assess the effect of age on overall survival (OS), cancer-specific survival (CSS), and non-cancer-related death (NCRD) in elderly (aged ≥70 years) head and neck squamous cell carcinoma (HNSCC) patients treated with definitive radiation therapy. The results were compared with those of younger patients, and the most important prognostic factors for survival endpoints were determined. Treatments may be better justified based on identification of the main differences in survival between young and elderly patients...
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28366581/information-needs-of-older-women-with-early-stage-breast-cancer-when-making-radiation-therapy-decisions
#20
Shi-Yi Wang, Gabrielle Kelly, Cary Gross, Brigid K Killelea, Sarah Mougalian, Carolyn Presley, Liana Fraenkel, Suzanne B Evans
PURPOSE: To identify the information older women with early-stage breast cancer need when making radiation therapy decisions, and who patients identify as the main decision maker. METHODS AND MATERIALS: We surveyed (through face-to-face interview, telephone, or mail) women aged ≥65 years who received lumpectomy and were considering or receiving adjuvant radiation therapy for early-stage breast cancer. The survey instrument was constructed with input from patient and professional advisory committees, including breast cancer survivors, advocates of breast cancer care and aging, clinicians, and researchers...
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
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