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International Journal of Radiation Oncology, Biology, Physics

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https://www.readbyqxmd.com/read/28454734/conservative-treatments-of-ocular-melanomas-technology-used-wisely-a-response-to-yazici-et%C3%A2-al
#1
EDITORIAL
Juliette Thariat, Joel Herault, Frederic Mouriaux
No abstract text is available yet for this article.
April 25, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28476434/survival-patterns-in-elderly-head-and-neck-squamous-cell-carcinoma-patients-treated-with-definitive-radiation-therapy
#2
Linda W Sommers, Roel J H M Steenbakkers, Henk P Bijl, Johanna G M Vemer-van den Hoek, Jan L N Roodenburg, Sjoukje F Oosting, Gyorgy B Halmos, Sophia E de Rooij, Johannes A Langendijk
PURPOSE: We sought to assess the effect of age on overall survival (OS), cancer-specific survival (CSS), and non-cancer-related death (NCRD) in elderly (aged ≥70 years) head and neck squamous cell carcinoma (HNSCC) patients treated with definitive radiation therapy. The results were compared with those of younger patients, and the most important prognostic factors for survival endpoints were determined. Treatments may be better justified based on identification of the main differences in survival between young and elderly patients...
March 6, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28479002/inhibition-of-bcl-2-xl-with-abt-263-selectively-kills-senescent-type-ii-pneumocytes-and-reverses-persistent-pulmonary-fibrosis-induced-by-ionizing-radiation-in-mice
#3
Jin Pan, Deguan Li, Yanfeng Xu, Junling Zhang, Yueying Wang, Mengyi Chen, Shuai Lin, Lan Huang, Eun Joo Chung, Deborah E Citrin, Yingying Wang, Martin Hauer-Jensen, Daohong Zhou, Aimin Meng
PURPOSE: Ionizing radiation (IR)-induced pulmonary fibrosis (PF) is an irreversible and severe late effect of thoracic radiation therapy. The goal of this study was to determine whether clearance of senescent cells with ABT-263, a senolytic drug that can selectively kill senescent cells, can reverse PF. METHODS AND MATERIALS: C57BL/6J mice were exposed to a single dose of 17 Gy on the right side of the thorax. Sixteen weeks after IR, they were treated with 2 cycles of vehicle or ABT-263 (50 mg/kg per day for 5 days per cycle) by gavage...
March 4, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28501419/brachytherapy-for-conservative-treatment-of-invasive-penile-carcinoma-prognostic-factors-and-long-term-analysis-of-outcome
#4
Alexandre Escande, Christine Haie-Meder, Renaud Mazeron, Pierre Maroun, Andrea Cavalcanti, Renaud de Crevoisier, Antoine Schernberg, Fanny Marsolat, Pierre Blanchard, Florent Martinetti, Alberto Bossi, Isabelle Dumas, Eric Deutsch, Cyrus Chargari
PURPOSE: To report the largest experience with brachytherapy as a conservative approach for the treatment of penile carcinoma. METHODS AND MATERIALS: We examined the outcomes of 201 patients treated at our institution over 45 years for invasive squamous cell carcinoma of the glans penis by brachytherapy. RESULTS: With a median follow-up of 10.7 years, local relapse as first failure was reported in 37 patients (18.9%), and 24 of 31 patients (77...
February 28, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28483336/prospective-study-of-cetuximab-carboplatin-and-radiation-therapy-for-patients-with-locally-advanced-head-and-neck-squamous-cell-cancer-unfit-for-cisplatin
#5
June Corry, Mathias Bressel, Tsien Fua, Alan Herschtal, Benjamin Solomon, Sandro V Porceddu, Chris Wratten, Danny Rischin
PURPOSE: To report on the outcomes of a novel treatment regimen for patients with locally advanced head and neck squamous cell carcinoma who were fit for curative treatment but not fit for cisplatin. METHODS AND MATERIALS: Single-arm phase 1/2 study of previously untreated patients with biopsy-proven SCC of the oropharynx, larynx, or hypopharynx. The primary endpoint was feasibility of the regimen, defined as the proportion of patients successfully completing treatment...
February 24, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28463175/in-reply-to-yazici-et%C3%A2-al
#6
LETTER
Awalpreet S Chadha, Yelin Suh, Sunil Krishnan
No abstract text is available yet for this article.
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28463174/in-reply-to-aronowitz
#7
LETTER
Anna Likhacheva, Timur Mitin, Evgeni Khmelevsky
No abstract text is available yet for this article.
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28463173/in-regard-to-chadha-et%C3%A2-al
#8
LETTER
Gozde Yazici, Sezin Yuce Sari, Mustafa Cengiz
No abstract text is available yet for this article.
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28463172/in-regard-to-likhacheva-et%C3%A2-al
#9
LETTER
Jesse N Aronowitz
No abstract text is available yet for this article.
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28463171/in-reply-to-singh
#10
LETTER
Loren K Mell, Igor Sirák, Umesh Mahantshetty
No abstract text is available yet for this article.
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28463170/in-regard-to-mell-et%C3%A2-al
#11
LETTER
Anshul Singh
No abstract text is available yet for this article.
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28463169/in-reply-to-hamstra-et%C3%A2-al
#12
LETTER
W James Morris
No abstract text is available yet for this article.
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28463168/in-regard-to-morris-et%C3%A2-al
#13
LETTER
Daniel A Hamstra, Daniel Krauss, Mark K Buyyounouski
No abstract text is available yet for this article.
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28463167/exploring-the-margin-recipe-for-online-adaptive-radiation-therapy-for-intermediate-risk-prostate-cancer-an-intrafractional-seminal-vesicles-motion-analysis
#14
Yang Sheng, Taoran Li, W Robert Lee, Fang-Fang Yin, Q Jackie Wu
PURPOSE: To provide a benchmark for seminal vesicle (SV) margin selection to account for intrafractional motion and to investigate the effectiveness of 2 motion surrogates in predicting intrafractional SV coverage. METHODS AND MATERIALS: Fifteen prostate patients were studied. Each patient had 5 pairs (1 patient had 4 pairs) of pretreatment and posttreatment cone beam CTs (CBCTs). Each pair of CBCTs was registered on the basis of prostate fiducial markers. All pretreatment SVs were expanded with 1-, 2-, 3-, 4-, 5-, and 8-mm isotropic margins to form a series of planning target volumes, and their intrafractional coverage to the posttreatment SV determined the "ground truth" for exact coverage...
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28463166/early-assessment-of-treatment-responses-during-radiation-therapy-for-lung-cancer-using-quantitative-analysis-of-daily-computed-tomography
#15
Jijo Paul, Cungeng Yang, Hui Wu, An Tai, Entesar Dalah, Cheng Zheng, Candice Johnstone, Feng-Ming Kong, Elizabeth Gore, X Allen Li
PURPOSE: To investigate early tumor and normal tissue responses during the course of radiation therapy (RT) for lung cancer using quantitative analysis of daily computed tomography (CT) scans. METHODS AND MATERIALS: Daily diagnostic-quality CT scans acquired using CT-on-rails during CT-guided RT for 20 lung cancer patients were quantitatively analyzed. On each daily CT set, the contours of the gross tumor volume (GTV) and lungs were generated and the radiation dose delivered was reconstructed...
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28463165/novel-super-resolution-approach-to-time-resolved-volumetric-4-dimensional-magnetic-resonance-imaging-with-high-spatiotemporal-resolution-for-multi-breathing-cycle-motion-assessment
#16
Guang Li, Jie Wei, Mo Kadbi, Jason Moody, August Sun, Shirong Zhang, Svetlana Markova, Kristen Zakian, Margie Hunt, Joseph O Deasy
PURPOSE: To develop and evaluate a super-resolution approach to reconstruct time-resolved 4-dimensional magnetic resonance imaging (TR-4DMRI) with a high spatiotemporal resolution for multi-breathing cycle motion assessment. METHODS AND MATERIALS: A super-resolution approach was developed to combine fast 3-dimensional (3D) cine MRI with low resolution during free breathing (FB) and high-resolution 3D static MRI during breath hold (BH) using deformable image registration...
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28463164/individualized-selection-of-beam-angles-and-treatment-isocenter-in-tangential-breast-intensity-modulated-radiation-therapy
#17
Joan Penninkhof, Sara Spadola, Sebastiaan Breedveld, Margreet Baaijens, Nico Lanconelli, Ben Heijmen
PURPOSE AND OBJECTIVE: Propose a novel method for individualized selection of beam angles and treatment isocenter in tangential breast intensity modulated radiation therapy (IMRT). METHODS AND MATERIALS: For each patient, beam and isocenter selection starts with the fully automatic generation of a large database of IMRT plans (up to 847 in this study); each of these plans belongs to a unique combination of isocenter position, lateral beam angle, and medial beam angle...
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28463163/medical-device-recalls-in-radiation-oncology-analysis-of-us-food-and-drug-administration-data-2002-2015
#18
Michael J Connor, Kathryn Tringale, Vitali Moiseenko, Deborah C Marshall, Kevin Moore, Laura Cervino, Todd Atwood, Derek Brown, Arno J Mundt, Todd Pawlicki, Abram Recht, Jona A Hattangadi-Gluth
PURPOSE: To analyze all recalls involving radiation oncology devices (RODs) from the US Food and Drug Administration (FDA)'s recall database, comparing these with non-radiation oncology device recalls to identify discipline-specific trends that may inform improvements in device safety. METHODS AND MATERIALS: Recall data on RODs from 2002 to 2015 were sorted into 4 product categories (external beam, brachytherapy, planning systems, and simulation systems). Outcomes included determined cause of recall, recall class (severity), quantity in commerce, time until recall termination (date FDA determines recall is complete), and time since 510(k) approval...
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28463162/stereotactic-ablative-radiation-therapy-for-pulmonary-metastases-histology-dose-and-indication-matter
#19
Joelle Helou, Isabelle Thibault, Ian Poon, Andrew Chiang, Suneil Jain, Hany Soliman, Darby Erler, Latifa Yeung, Patrick Cheung
PURPOSE: To assess the association between colorectal cancer (CRC) histology, dose, and local failure (LF) after stereotactic ablative radiation therapy (SABR) for pulmonary metastases, and to describe subsequent cancer progression, change of systemic therapy (CST), survival, and their association with treatment indications. METHODS AND MATERIALS: From a prospective SABR cohort, 180 pulmonary metastases in 120 patients were identified. Treatment indications were single metastasis, oligometastases, oligoprogression, and dominant areas of progression...
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28463161/feasibility-of-patient-reporting-of-symptomatic-adverse-events-via-the-patient-reported-outcomes-version-of-the-common-terminology-criteria-for-adverse-events-pro-ctcae-in-a-chemoradiotherapy-cooperative-group-multicenter-clinical-trial
#20
Ethan Basch, Stephanie L Pugh, Amylou C Dueck, Sandra A Mitchell, Lawrence Berk, Shannon Fogh, Lauren J Rogak, Marcha Gatewood, Bryce B Reeve, Tito R Mendoza, Ann M O'Mara, Andrea M Denicoff, Lori M Minasian, Antonia V Bennett, Ann Setser, Deborah Schrag, Kevin Roof, Joan K Moore, Thomas Gergel, Kevin Stephans, Andreas Rimner, Albert DeNittis, Deborah Watkins Bruner
PURPOSE: To assess the feasibility of measuring symptomatic adverse events (AEs) in a multicenter clinical trial using the National Cancer Institute's Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE). METHODS AND MATERIALS: Patients enrolled in NRG Oncology's RTOG 1012 (Prophylactic Manuka Honey for Reduction of Chemoradiation Induced Esophagitis-Related Pain during Treatment of Lung Cancer) were asked to self-report 53 PRO-CTCAE items representing 30 symptomatic AEs at 6 time points (baseline; weekly ×4 during treatment; 12 weeks after treatment)...
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
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