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International Journal of Radiation Oncology, Biology, Physics

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https://www.readbyqxmd.com/read/28011050/could-the-addition-of-cetuximab-to-conventional-radiation-therapy-improve-organ-preservation-in-those-patients-with-locally-advanced-larynx-cancer-who-respond-to-induction-chemotherapy-an-organ-preservation-spanish-head-and-neck-cancer-cooperative-group-phase
#1
Ricard Mesía, Jose A Garcia-Saenz, Alicia Lozano, Miguel Pastor, Juan J Grau, Javier Martínez-Trufero, Julio Lambeaz, Joaquina Martínez-Galán, Jose R Mel, Belen González, Silvia Vázquez, Manel Mañós, Miren Taberna, Beatriz Cirauqui, Elvira Del Barco, Esther Casado, Jordi Rubió-Casadevall, Angles Rodríguez-Jaráiz, Juan J Cruz
PURPOSE: To evaluate the efficacy and safety of induction chemotherapy (IC) followed by bioradiotherapy (BRT) to achieve functional larynx preservation in the setting of locally advanced head and neck tumors. METHODS AND MATERIALS: This was a phase 2, open-label, multicenter study of patients with stage III and IVA laryngeal carcinoma who were candidates for total laryngectomy. The primary endpoint was the rate of survival with functional larynx (SFL) at 3 years, with a critical value to consider the study positive of SFL >59%...
November 17, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28011045/diffusion-weighted-magnetic-resonance-imaging-as-a-predictor-of-outcome-in-cervical-cancer-after-chemoradiation
#2
Jennifer C Ho, Pamela K Allen, Priya R Bhosale, Gaiane M Rauch, Clifton D Fuller, Abdallah S R Mohamed, Michael Frumovitz, Anuja Jhingran, Ann H Klopp
PURPOSE: To determine whether apparent diffusion coefficient (ADC) value is predictive of survival after definitive chemoradiation for cervical cancer independent of established imaging and clinical prognostic factors. METHODS AND MATERIALS: Between 2011 and 2013, the pretreatment MRI scans for 69 patients treated with definitive chemoradiation for newly diagnosed cervical cancer were retrieved. Scans were acquired with a 1.5-T magnetic resonance scanner, including diffusion-weighted imaging sequences...
November 17, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28011049/effect-of-anatomic-changes-on-pencil-beam-scanned-proton-dose-distributions-for-cranial-and-extracranial-tumors
#3
Lorenzo Placidi, Alessandra Bolsi, Antony J Lomax, Ralf A Schneider, Robert Malyapa, Damien C Weber, Francesca Albertini
PURPOSE: To estimate the frequency and impact of anatomic changes on the delivered dose in pencil beam scanning proton therapy, to assess the need for repeat CT scanning and adaptive replanning. METHODS AND MATERIALS: A total of 730 patients treated at Paul Scherrer Institut between 2007 and 2014 were included in this study, for which the number of patients who had control CT scans and who were replanned as a result of anatomic changes was analyzed. For those that were replanned, the nominal dose distributions (originally optimized on the planning CT scan) were recalculated on the replanning CT scan and differences evaluated using standard dose metrics for planning target volumes and clinical target volumes and organs at risk (OARs)...
November 16, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28011051/a-phase-2-trial-of-neoadjuvant-temozolomide-followed-by-hypofractionated-accelerated-radiation-therapy-with-concurrent-and-adjuvant-temozolomide-for-patients-with-glioblastoma
#4
George Shenouda, Luis Souhami, Kevin Petrecca, Scott Owen, Valerie Panet-Raymond, Marie-Christine Guiot, Andrea Gomez Corredor, Bassam Abdulkarim
PURPOSE: We performed a phase 2 trial of neoadjuvant temozolomide (TMZ), followed by hypofractionated accelerated radiation therapy (HART) with concurrent TMZ, and adjuvant TMZ in patients with newly diagnosed glioblastoma to determine whether neoadjuvant TMZ would safely improve outcomes in this group of patients prior to subsequent cytotoxic therapy. METHODS AND MATERIALS: Adult patients with newly diagnosed glioblastoma and a Karnofsky Performance Status >60 were eligible...
November 15, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28011044/association-of-radiomics-and-metabolic-tumor-volumes-in-radiation-treatment-of-glioblastoma-multiforme
#5
Christopher J Lopez, Natalya Nagornaya, Nestor A Parra, Deukwoo Kwon, Fazilat Ishkanian, Arnold M Markoe, Andrew Maudsley, Radka Stoyanova
PURPOSE: To build a framework for investigation of the associations between imaging, clinical target volumes (CTVs), and metabolic tumor volumes (MTVs) features for better understanding of the underlying information in the CTVs and dependencies between these volumes. High-throughput extraction of imaging and metabolomic quantitative features from magnetic resonance imaging (MRI) and magnetic resonance spectroscopic imaging of glioblastoma multiforme (GBM) results in tens of variables per patient...
November 15, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28011048/direct-comparison-of-respiration-correlated-four-dimensional-magnetic-resonance-imaging-reconstructed-using-concurrent-internal-navigator-and-external-bellows
#6
Guang Li, Jie Wei, Devin Olek, Mo Kadbi, Neelam Tyagi, Kristen Zakian, James Mechalakos, Joseph O Deasy, Margie Hunt
PURPOSE: To compare the image quality of amplitude-binned 4-dimensional magnetic resonance imaging (4DMRI) reconstructed using 2 concurrent respiratory (navigator and bellows) waveforms. METHODS AND MATERIALS: A prospective, respiratory-correlated 4DMRI scanning program was used to acquire T2-weighted single-breath 4DMRI images with internal navigator and external bellows. After a 10-second training waveform of a surrogate signal, 2-dimensional MRI acquisition was triggered at a level (bin) and anatomic location (slice) until the bin-slice table was completed for 4DMRI reconstruction...
November 9, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28011046/promoting-the-appropriate-use-of-advanced-radiation-technologies-in-oncology-summary-of-a-national-cancer-policy-forum-workshop
#7
Grace L Smith, Patricia A Ganz, Justin E Bekelman, Steven J Chmura, James J Dignam, Jason A Efstathiou, Reshma Jagsi, Peter A Johnstone, Michael L Steinberg, Stephen B Williams, James B Yu, Anthony L Zietman, Ralph R Weichselbaum, Ya-Chen Tina Shih
PURPOSE: Leaders in the oncology community are sounding a clarion call to promote "value" in cancer care decisions. Value in cancer care considers the clinical effectiveness, along with the costs, when selecting a treatment. To discuss possible solutions to the current obstacles to achieving value in the use of advanced technologies in oncology, the National Cancer Policy Forum of the National Academies of Sciences, Engineering, and Medicine held a workshop, "Appropriate Use of Advanced Technologies for Radiation Therapy and Surgery in Oncology" in July 2015...
November 8, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28068255/in-regard-to-speers-et%C3%A2-al
#8
LETTER
Alice Lee
No abstract text is available yet for this article.
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28068254/in-regard-to-arthurs-et%C3%A2-al
#9
LETTER
Pierre Blanchard, Adam S Garden
No abstract text is available yet for this article.
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28068253/in-reply-to-ghadjar-et-al
#10
LETTER
Thomas M Pisansky, Rahul D Tendulkar
No abstract text is available yet for this article.
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28068252/in-regard-to-pisansky-et%C3%A2-al
#11
LETTER
Pirus Ghadjar, Stefanie Hayoz, Daniel R Zwahlen, George N Thalmann, Daniel M Aebersold
No abstract text is available yet for this article.
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28068251/in-regard-to-lee-et%C3%A2-al
#12
LETTER
Puneet Pareek
No abstract text is available yet for this article.
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28068250/in-reply-to-pareek
#13
LETTER
Nancy Lee, John Humm, Nadeem Riaz
No abstract text is available yet for this article.
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28068249/rod-withers-data-are-available-online
#14
EDITORIAL
Howard D Thames, Nancy R Hunter, Kathy A Mason
No abstract text is available yet for this article.
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28068248/clinical-implementation-of-dual-energy-ct-for-proton-treatment-planning-on-pseudo-monoenergetic-ct-scans
#15
Patrick Wohlfahrt, Christian Möhler, Volker Hietschold, Stefan Menkel, Steffen Greilich, Mechthild Krause, Michael Baumann, Wolfgang Enghardt, Christian Richter
PURPOSE: To determine whether a standardized clinical application of dual-energy computed tomography (DECT) for proton treatment planning based on pseudomonoenergetic CT scans (MonoCTs) is feasible and increases the precision of proton therapy in comparison with single-energy CT (SECT). METHODS AND MATERIALS: To define an optimized DECT protocol, CT scan settings were analyzed experimentally concerning beam hardening, image quality, and influence on the heuristic conversion of CT numbers into stopping-power ratios (SPRs) and were compared with SECT scans with identical CT dose...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28068247/modeling-urinary-dysfunction-after-external-beam-radiation-therapy-of-the-prostate-using-bladder-dose-surface-maps-evidence-of-spatially-variable-response-of-the-bladder-surface
#16
Noorazrul Yahya, Martin A Ebert, Michael J House, Angel Kennedy, John Matthews, David J Joseph, James W Denham
PURPOSE: We assessed the association of the spatial distribution of dose to the bladder surface, described using dose-surface maps, with the risk of urinary dysfunction. METHODS AND MATERIALS: The bladder dose-surface maps of 754 participants from the TROG 03.04-RADAR trial were generated from the volumetric data by virtually cutting the bladder at the sagittal slice, intersecting the bladder center-of-mass through to the bladder posterior and projecting the dose information on a 2-dimensional plane...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28068246/intercellular-adhesion-molecule-1-and-vascular-cell-adhesion-molecule-are-induced-by-ionizing-radiation-on-lymphatic-endothelium
#17
María E Rodriguez-Ruiz, Saray Garasa, Inmaculada Rodriguez, Jose Luis Solorzano, Benigno Barbes, Alba Yanguas, Alvaro Teijeira, Iñaki Etxeberria, José Javier Aristu, Cornelia Halin, Ignacio Melero, Ana Rouzaut
PURPOSE/OBJECTIVES: The goal of this study was to assess the effects of ionizing radiation on the expression of the integrin ligands ICAM-1 and VCAM that control leucocyte transit by lymphatic endothelial cells. MATERIALS/METHODS: Confluent monolayers of primary human lymphatic endothelial cells (LEC) were irradiated with single dose of 2, 5, 10 or 20 Gy, with 6 MeV-x-rays using a Linear-Accelerator. ICAM-1 and VCAM expression was determined by flow cytometry. Human tissue specimens received a single dose of 20 Gy with 15 MeV-x-rays...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28068245/ku70-ku80-and-sclusterin-a-cluster-of-predicting-factors-for-response-to-neoadjuvant-chemoradiation-therapy-in-patients-with-locally-advanced-rectal-cancer
#18
Sabina Pucci, Chiara Polidoro, Alessandro Joubert, Francesca Mastrangeli, Barbara Tolu, Michaela Benassi, Valeria Fiaschetti, Laura Greco, Roberto Miceli, Roberto Floris, Giuseppe Novelli, Augusto Orlandi, Riccardo Santoni
PURPOSE: The identification of predictive biomarkers for neoadjuvant chemoradiation therapy (CRT) is a current clinical need. The heterodimer Ku70/80 plays a critical role in DNA repair and cell death induction after damage. The aberrant expression and localization of these proteins fail to control DNA repair and apoptosis. sClusterin is the Ku70 partner that sterically inhibits Bax-dependent cell death after damage in some pathologic conditions. This study sought to evaluate the molecular relevance of Ku70-Ku80-Clu as a molecular cluster predicting the response to neoadjuvant CRT in patients with locally advanced rectal cancer (LARC)...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28068244/-18-f-fluorodeoxyglucose-positron-emission-tomography-predicts-patterns-of-failure-after-definitive-chemoradiation-therapy-for-locally-advanced-non-small-cell-lung-cancer
#19
Nitin Ohri, William R Bodner, Balazs Halmos, Haiying Cheng, Roman Perez-Soler, Steven M Keller, Shalom Kalnicki, Madhur Garg
BACKGROUND: We previously reported that pretreatment positron emission tomography (PET) identifies lesions at high risk for progression after concurrent chemoradiation therapy (CRT) for locally advanced non-small cell lung cancer (NSCLC). Here we validate those findings and generate tumor control probability (TCP) models. METHODS: We identified patients treated with definitive, concurrent CRT for locally advanced NSCLC who underwent staging (18)F-fluorodeoxyglucose/PET/computed tomography...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28068243/sentinel-lymph-node-dissection-to-select-clinically-node-negative-prostate-cancer-patients-for-pelvic-radiation-therapy-effect-on-biochemical-recurrence-and-systemic-progression
#20
Nikolaos Grivas, Esther Wit, Floris Pos, Jeroen de Jong, Erik Vegt, Axel Bex, Kees Hendricksen, Simon Horenblas, Gijs KleinJan, Bas van Rhijn, Henk van der Poel
PURPOSE: To assess the efficacy of robotic-assisted laparoscopic sentinel lymph node (SLN) dissection (SLND) to select those patients with prostate cancer (PCa) who would benefit from additional pelvic external beam radiation therapy and long-term androgen deprivation therapy (ADT). METHODS AND MATERIALS: Radioisotope-guided SLND was performed in 224 clinically node-negative patients scheduled to undergo external beam radiation therapy. Patients with histologically positive SLNs (pN1) were also offered radiation therapy to the pelvic lymph nodes, combined with 3 years of ADT...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
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