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International Journal of Radiation Oncology, Biology, Physics

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https://www.readbyqxmd.com/read/29325810/current-and-future-initiatives-for-radiation-oncology-at-the-national-cancer-institute-in-the-era-of-precision-medicine
#1
EDITORIAL
Charles A Kunos, C Norman Coleman
No abstract text is available yet for this article.
January 8, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29306585/radiation-safety-for-pregnant-workers-at-a-proton-facility
#2
Genevieve Maquilan, Marc R Bussière, Joseph McCormack, Tara Medich, Andrzej Niemierko, Helen A Shih
PURPOSE: To quantify radiation exposure of radiation therapy technologists (RTTs) in a proton treatment facility in comparison with a photon therapy facility, to inform and establish these specialized occupational safety guidelines. METHODS AND MATERIALS: Two groups of RTTs, consisting of 12 full-time passive scattering proton RTTs and 18 full-time conventional photon RTTs, wore an additional dosimetry badge at the waist for a period of 14 weeks. The 2 groups of RTTs were given identical instructions on the proper use of the badges...
November 16, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29246722/development-and-validation-of-a-predictive-radiomics-model-for-clinical-outcomes-in-stage-i-non-small-cell-lung-cancer
#3
Wen Yu, Chad Tang, Brian P Hobbs, Xiao Li, Eugene J Koay, Ignacio I Wistuba, Boris Sepesi, Carmen Behrens, Jaime Rodriguez Canales, Edwin Roger Parra Cuentas, Jeremy J Erasmus, Laurence E Court, Joe Y Chang
PURPOSE: To develop and validate a radiomics signature that can predict the clinical outcomes for patients with stage I non-small cell lung cancer (NSCLC). METHODS AND MATERIALS: We retrospectively analyzed contrast-enhanced computed tomography images of patients from a training cohort (n = 147) treated with surgery and an independent validation cohort (n = 295) treated with stereotactic ablative radiation therapy. Twelve radiomics features with established strategies for filtering and preprocessing were extracted...
November 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29248168/low-dose-hypersensitive-response-for-residual-patm-and-%C3%AE-h2ax-foci-in-normal-fibroblasts-of-cancer-patients
#4
Dorota Słonina, Aleksandra Kowalczyk, Anna Janecka-Widła, Damian Kabat, Wiktor Szatkowski, Beata Biesaga
PURPOSE: To define the dose-response relationship for initial and residual pATM and γH2AX foci and temporal response of pATM foci in fibroblasts of 4 hyper-radiosensitivity (HRS)-positive cancer patients and 8 HRS-negative cancer patients and answer the question regarding the role of DNA double-strand break (DSB) recognition and repair in the mechanism of HRS. METHODS AND MATERIALS: The cells were irradiated with single doses (0.1-4 Gy) of 6-MV X rays. The number of initial and residual pATM and γH2AX foci was assessed 1 hour and 24 hours after irradiation, respectively...
November 6, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29246721/functional-outcomes-after-de-escalated-chemoradiation-therapy-for-human-papillomavirus-positive-oropharyngeal-cancer-secondary-analysis-of-a-phase-2-trial
#5
John V Hegde, Narek Shaverdian, Carol Felix, Pin-Chieh Wang, Darlene Veruttipong, Sophia Hsu, Jonathan W Riess, Shyam D Rao, Megan E Daly, Allen M Chen
PURPOSE: To analyze functional outcomes for patients treated on a phase 2 trial of de-escalated chemoradiation therapy for human papillomavirus-positive oropharyngeal cancer. METHODS AND MATERIALS: Patient eligibility included p16-positive, stage III or IV oropharyngeal squamous cell carcinoma and a Zubrod performance status of 0 to 1. Treatment was induction chemotherapy with paclitaxel, 175 mg/m2, and carboplatin, area under the curve (AUC) of 6 mg/ml/min, for 2 cycles every 21 days, followed by concurrent paclitaxel, 30 mg/m2, every 7 days with dose-reduced radiation therapy of 54 or 60 Gy...
November 6, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29249529/optimal-high-dose-rate-brachytherapy-fractionation-scheme-after-keloid-excision-a%C3%A2-retrospective-multicenter-comparison-of-recurrence-rates-and-complications
#6
Eveline Bijlard, Gerda M Verduijn, J X Harmeling, Homan Dehnad, Frank B Niessen, Otto W M Meijer, Marc A M Mureau
PURPOSE: To determine the optimal brachytherapy dose and fractionation scheme for keloid treatment. METHODS AND MATERIALS: Patient cohorts from 3 centers treated with keloid excision followed by 2 × 9 Gy, 3 × 6 Gy, or 2 × 6 Gy high-dose-rate brachytherapy were retrospectively compared regarding recurrence (after at least 12 months' follow-up) and complications (after at least 1 month's follow-up), using logistic regression analyses. RESULTS: A total of 238 keloids were treated...
November 4, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29248169/simultaneous-integrated-boost-for-radiation-dose-escalation-to-the-gross-tumor-volume-with-intensity-modulated-photon-radiation-therapy-or-intensity-modulated-proton-therapy-and-concurrent-chemotherapy-for-stage-ii-to-iii-non-small-cell-lung-cancer-a-phase
#7
Melenda D Jeter, Daniel Gomez, Quynh-Nhu Nguyen, Ritsuko Komaki, Xiaodong Zhang, Xiaorong Zhu, Michael O'Reilly, Frank V Fossella, Ting Xu, Xiong Wei, Hui Wang, Wenjuan Yang, Anne Tsao, Radhe Mohan, Zhongxing Liao
PURPOSE: To establish, in the phase 1 portion of a prospective phase 1/2 study, the maximum tolerated dose of image guided intensity modulated radiation therapy (IMRT) or proton therapy (IMPT), both with a simultaneous integrated boost (SIB), for patients with stage II to IIIB non-small cell lung cancer receiving concurrent chemoradiation therapy. METHODS AND MATERIALS: Patients had pathologically proven non-small cell lung cancer, either unresectable stage II to IIIB disease or recurrent disease after surgical resection, and could tolerate concurrent chemoradiation...
November 3, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29249526/curative-radiation-therapy-at-time-of-progression-under-active-surveillance-compared-with-up-front-radical-radiation-therapy-for-prostate-cancer
#8
Alejandro Berlin, Ardalan E Ahmad, Melvin L K Chua, Fabio Y Moraes, Haiyan Jiang, Maria Komisarenko, Narhari Trimilshina, Hamid Raziee, Ali Hosni, Jure Murgic, Peter Chung, Robert G Bristow, Antonio Finelli
PURPOSE: To describe and compare outcomes in men with initially presumed indolent prostate cancer receiving definitive radiation therapy after active surveillance (AS) versus those in a risk-matched cohort undergoing up-front radiation therapy. METHODS AND MATERIALS: Men prospectively enrolled in an AS program between 1992 and 2014 and subsequently undergoing curative radiation therapy (ie, image guided radiation therapy [IGRT] or low-dose-rate brachytherapy [LDR-BT]) were identified...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29249528/critical-appraisal-of-the-risk-of-secondary-cancer-induction-from-breast-radiation-therapy-with-volumetric-modulated-arc-therapy-relative-to-3d-conformal-therapy
#9
Antonella Fogliata, Fiorenza De Rose, Davide Franceschini, Antonella Stravato, Jan Seppälä, Marta Scorsetti, Luca Cozzi
PURPOSE: To evaluate the excess absolute risk (EAR) comparing volumetric modulated arc therapy (VMAT) and 3-dimensional (3D) conformal radiation therapy (CRT) in breast cancer radiation therapy treatment. METHODS AND MATERIALS: Two VMAT arrangements (VMAT_tang and VMAT_full, i.e. partial arcs with and without a sector of 0 Monitor Unit, respectively) and a 3D CRT (field-in-field [FinF]) plan were calculated with an accurate dose calculation algorithm, Acuros, in 20 patients presenting with early-stage breast cancer...
October 31, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29249527/positron-emission-tomography-adjusted-intensity-modulated-radiation-therapy-for-locally-advanced-non-small-cell-lung-cancer
#10
Nitin Ohri, William R Bodner, Rafi Kabarriti, Viswanathan Shankar, Haiying Cheng, Tony Abraham, Balazs Halmos, Rasim Gucalp, Roman Perez-Soler, Shalom Kalnicki, Madhur Garg
PURPOSE: To perform a prospective trial examining positron emission tomography (PET)-based, dose-painted intensity modulated radiation therapy (IMRT) in the setting of locally advanced non-small cell lung cancer (NSCLC). METHODS AND MATERIALS: Patients with stage IIB-III NSCLC were treated with 25 fractions of dose-painted IMRT. Tumors or lymph nodes with metabolic tumor volume exceeding 25 cm3 were deemed "high risk" and received 65 Gy. Smaller lesions were treated with 57 Gy or 52...
October 28, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29229329/prognostic-value-of-c-met-expression-in-patients-with-pancreatic-cancer-receiving-adjuvant-and-neoadjuvant-chemoradiation-therapy
#11
Kyle C Cuneo, Meredith A Morgan, Kent A Griffith, Peter G Hawkins, Joel K Greenson, Edgar Ben-Josef, Theodore S Lawrence, Mark M Zalupski
PURPOSE: To determine the prognostic significance of c-MET expression and develop a predictor of distant failure in patients with resectable pancreatic cancer treated with chemoradiation. METHODS AND MATERIALS: We used a tissue microarray to study protein expression by immunohistochemistry in 102 patients treated surgically for pancreatic cancer. Two cores per patient were blindly scored from 0 (no staining) to 3 (strong staining) by a single pathologist. The Kaplan-Meier method was used to determine time to local and distant failure, overall survival, and progression-free survival...
October 28, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29229324/comparison-of-36%C3%A2-gy-20%C3%A2-gy-or-no-radiation-therapy-after-6-cycles-of-ebvp-chemotherapy-and-complete-remission-in-early-stage-hodgkin-lymphoma-without-risk-factors-results-of-the-eort-gela-h9-f-intergroup-randomized-trial
#12
José Thomas, Christophe Fermé, Evert M Noordijk, Franck Morschhauser, Théodore Girinsky, Isabelle Gaillard, Pieternella J Lugtenburg, Marc André, Marnix L M Lybeert, Aspasia Stamatoullas, Max Beijert, Philippe Hélias, Houchingue Eghbali, Jean Gabarre, Richard W M van der Maazen, Jérôme Jaubert, Krimo Bouabdallah, Olivier Boulat, Judith M Roesink, Bernard Christian, Francisca Ong, Dominique Bordessoule, Gérard Tertian, Hugo Gonzalez, Andrej Vranovsky, Philippe Quittet, Umberto Tirelli, Daphne de Jong, Josée Audouin, Berthe M P Aleman, Michel Henry-Amar
PURPOSE: While patients with early-stage Hodgkin lymphoma (HL) have an excellent outcome with combined treatment, the radiation therapy (RT) dose and treatment with chemotherapy alone remain questionable. This noninferiority trial evaluates the feasibility of reducing the dose or omitting RT after chemotherapy. METHODS AND MATERIALS: Patients with untreated supradiaphragmatic HL without risk factors (age ≥ 50 years, 4 to 5 nodal areas involved, mediastinum-thoracic ratio ≥ 0...
October 27, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29254783/time-driven-activity-based-costing-in-oncology-a-step-in-the-right-direction
#13
EDITORIAL
Sushil Beriwal, Junzo Chino
No abstract text is available yet for this article.
January 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29254782/prostate-specific-antigen-psa-bounce-after-dose-escalated-external-beam-radiation-therapy-is-an-independent-predictor-of-psa-recurrence-metastasis-and-survival-in-prostate-adenocarcinoma-patients
#14
Paul B Romesser, Xin Pei, Weiji Shi, Zhigang Zhang, Marisa Kollmeier, Sean M McBride, Michael J Zelefsky
PURPOSE: To evaluate the difference in prostate-specific antigen (PSA) recurrence-free, distant metastasis-free, overall, and cancer-specific survival between PSA bounce (PSA-B) and non-bounce patients treated with dose-escalated external beam radiation therapy (DE-EBRT). METHODS AND MATERIALS: During 1990-2010, 1898 prostate adenocarcinoma patients were treated with DE-EBRT to ≥75 Gy with ≥5 years follow-up. Patients receiving neoadjuvant/concurrent androgen-deprivation therapy (n=1035) or with fewer than 4 PSA values obtained 6 months or more after post-EBRT completion (n=87) were excluded...
January 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29254781/lack-of-apparent-survival-benefit-with-use-of-androgen-deprivation-therapy-in-patients-with-high-risk-prostate-cancer-receiving-combined-external-beam-radiation-therapy-and-brachytherapy
#15
David D Yang, Vinayak Muralidhar, Brandon A Mahal, Paul L Nguyen, Phillip M Devlin, Martin T King, Peter F Orio
PURPOSE: Although level 1 evidence has demonstrated a survival benefit from the addition of androgen deprivation therapy (ADT) to external beam radiation therapy (EBRT) for patients with high-risk prostate cancer, the benefits of ADT with combined EBRT and brachytherapy for high-risk patients are unclear. We examined the association between ADT and overall survival in a national cohort of high-risk patients treated with EBRT with or without brachytherapy. METHODS AND MATERIALS: We identified 46,325 men in the National Cancer Database with a diagnosis of high-risk prostate cancer (Gleason score 8-10, clinical stage T3-T4, or prostate-specific antigen >20 ng/mL) who were treated with EBRT with or without brachytherapy and ADT from 2004 through 2011...
January 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29254780/radiation-oncology-in-the-netherlands
#16
EDITORIAL
Ben J Slotman, Pieter Vos, Annerie Slot, Ronald Keus, Marcel Verheij
No abstract text is available yet for this article.
January 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29254779/erratum-to-kanehira-t-matsuura-t-takao-s-et%C3%A2-al-impact-of-real-time-image-gating-on-spot-scanning-proton-therapy-for-lung-tumors-a-simulation-study-int%C3%A2-j-radiat-oncol-biol-phys-2016-97-173-181
#17
(no author information available yet)
No abstract text is available yet for this article.
January 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29254778/in-reply-to-thomas
#18
LETTER
Christina Hunter Chapman, Reshma Jagsi
No abstract text is available yet for this article.
January 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29254777/in-regard-to-chapman-and-jagsi
#19
LETTER
Charles R Thomas
No abstract text is available yet for this article.
January 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29254776/breast-cancer-biology-clinical-implications-for-breast-radiation-therapy
#20
REVIEW
Janet K Horton, Reshma Jagsi, Wendy A Woodward, Alice Ho
Historically, prognosis and treatment decision making for breast cancer patients have been dictated by the anatomic extent of tumor spread. However, in recent years, "breast cancer" has proven to be a collection of unique phenotypes with distinct prognoses, patterns of failure, and treatment responses. Recent advances in biologically based assays and targeted therapies designed to exploit these unique phenotypes have profoundly altered systemic therapy practice patterns and treatment outcomes. Data associating locoregional outcomes with tumor biology are emerging...
January 1, 2018: International Journal of Radiation Oncology, Biology, Physics
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