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International Journal of Radiation Oncology, Biology, Physics

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https://www.readbyqxmd.com/read/27843029/stereotactic-body-radiation-therapy-and-the-influence-of-chemotherapy-on-overall-survival-for-large-%C3%A2-5-centimeter-non-small-cell-lung-cancer
#1
Vivek Verma, Matthew T McMillan, Surbhi Grover, Charles B Simone
PURPOSE: Stereotactic body radiation therapy (SBRT) for ≥5 cm lesions is poorly defined, largely owing to the low sample sizes in existing studies. The present analysis examined the SBRT outcomes and assessed the effect of chemotherapy in this population. METHODS AND MATERIALS: The National Cancer Data Base was queried for primary non-small cell lung cancer ≥5 cm treated with SBRT (≤10 fractions). Patient, tumor, and treatment parameters were extracted. The primary outcome was overall survival (OS)...
September 29, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27839909/histologic-subtype-in-core-lung-biopsies-of-early-stage-lung-adenocarcinoma-is-a-prognostic-factor-for-treatment-response-and-failure-patterns-after-stereotactic-body-radiation-therapy
#2
Jonathan E Leeman, Andreas Rimner, Joseph Montecalvo, Meier Hsu, Zhigang Zhang, Donata von Reibnitz, Kelly Panchoo, Ellen Yorke, Prasad S Adusumilli, William Travis, Abraham J Wu
PURPOSE: Stereotactic body radiation therapy (SBRT) has emerged as an effective treatment for early-stage lung cancer. The histologic subtype of surgically resected lung adenocarcinoma is recognized as a prognostic factor, with the presence of solid or micropapillary patterns predicting poor outcomes. We describe the outcomes after SBRT for early-stage lung adenocarcinoma stratified by histologic subtype. METHODS AND MATERIALS: We identified 119 consecutive patients (124 lesions) with stage I to IIA lung adenocarcinoma who had undergone definitive SBRT at our institution from August 2008 to August 2015 and had undergone core biopsy...
September 29, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27856039/impact-of-real-time-image-gating-on-spot-scanning-proton-therapy-for-lung-tumors-a%C3%A2-simulation-study
#3
Takahiro Kanehira, Taeko Matsuura, Seishin Takao, Yuka Matsuzaki, Yusuke Fujii, Takaaki Fujii, Yoichi M Ito, Naoki Miyamoto, Tetsuya Inoue, Norio Katoh, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
PURPOSE: To investigate the effectiveness of real-time-image gated proton beam therapy for lung tumors and to establish a suitable size for the gating window (GW). METHODS AND MATERIALS: A proton beam gated by a fiducial marker entering a preassigned GW (as monitored by 2 fluoroscopy units) was used with 7 lung cancer patients. Seven treatment plans were generated: real-time-image gated proton beam therapy with GW sizes of ±1, 2, 3, 4, 5, and 8 mm and free-breathing proton therapy...
September 28, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27843033/benchmark-credentialing-results-for-nrg-br001-the-first-national-cancer-institute-sponsored-trial-of-stereotactic-body-radiation-therapy-for-multiple-metastases
#4
Hania A Al-Hallaq, Steven J Chmura, Joseph K Salama, Jessica R Lowenstein, Susan McNulty, James M Galvin, David S Followill, Clifford G Robinson, Thomas M Pisansky, Kathryn A Winter, Julia R White, Ying Xiao, Martha M Matuszak
PURPOSE: The NRG-BR001 trial is the first National Cancer Institute-sponsored trial to treat multiple (range 2-4) extracranial metastases with stereotactic body radiation therapy. Benchmark credentialing is required to ensure adherence to this complex protocol, in particular, for metastases in close proximity. The present report summarizes the dosimetric results and approval rates. METHODS AND MATERIALS: The benchmark used anonymized data from a patient with bilateral adrenal metastases, separated by <5 cm of normal tissue...
September 28, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27843032/volume-of-lytic-vertebral-body-metastatic-disease-quantified-using-computed-tomography-based-image-segmentation-predicts-fracture-risk-after-spine-stereotactic-body-radiation-therapy
#5
Isabelle Thibault, Cari M Whyne, Stephanie Zhou, Mikki Campbell, Eshetu G Atenafu, Sten Myrehaug, Hany Soliman, Young K Lee, Hamid Ebrahimi, Albert J M Yee, Arjun Sahgal
PURPOSE: To determine a threshold of vertebral body (VB) osteolytic or osteoblastic tumor involvement that would predict vertebral compression fracture (VCF) risk after stereotactic body radiation therapy (SBRT), using volumetric image-segmentation software. METHODS AND MATERIALS: A computational semiautomated skeletal metastasis segmentation process refined in our laboratory was applied to the pretreatment planning CT scan of 100 vertebral segments in 55 patients treated with spine SBRT...
September 28, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27839910/positron-emission-tomography-computed-tomography-assessment-after-immunochemotherapy-and-irradiation-using-the-lugano-classification-criteria-in-the-ielsg-26-study-of-primary-mediastinal-b-cell-lymphoma
#6
Luca Ceriani, Maurizio Martelli, Maria K Gospodarowicz, Umberto Ricardi, Andrés J M Ferreri, Annalisa Chiappella, Caterina Stelitano, Monica Balzarotti, Maria E Cabrera, David Cunningham, Attilio Guarini, Pier Luigi Zinzani, Luca Giovanella, Peter W M Johnson, Emanuele Zucca
PURPOSE: To assess the predictive value of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) for disease recurrence after immunochemotherapy (R-CHT) and mediastinal irradiation (RT), using the recently published criteria of the Lugano classification to predict outcomes for patients with primary mediastinal large B-cell lymphoma. METHODS AND MATERIALS: Among 125 patients prospectively enrolled in the IELSG-26 study, 88 were eligible for central review of PET/CT scans after completion of RT...
September 28, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27843031/influence-of-institutional-experience-and-technological-advances-on-outcome-of-stereotactic-body-radiation-therapy-for-oligometastatic-lung-disease
#7
Juliane Rieber, Nasrin Abbassi-Senger, Sonja Adebahr, Nicolaus Andratschke, Oliver Blanck, Marciana Duma, Michael J Eble, Iris Ernst, Michael Flentje, Sabine Gerum, Peter Hass, Christoph Henkenberens, Guido Hildebrandt, Detlef Imhoff, Henning Kahl, Nathalie Desirée Klass, Robert Krempien, Fabian Lohaus, Frank Lohr, Cordula Petersen, Elsge Schrade, Jan Streblow, Lorenz Uhlmann, Andrea Wittig, Florian Sterzing, Matthias Guckenberger
PURPOSE: Many technological and methodical advances have made stereotactic body radiotherapy (SBRT) more accurate and more efficient during the last years. This study aims to investigate whether experience in SBRT and technological innovations also translated into improved local control (LC) and overall survival (OS). METHODS AND MATERIALS: A database of 700 patients treated with SBRT for lung metastases in 20 German centers between 1997 and 2014 was used for analysis...
September 26, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27843030/adjuvant-radiation-therapy-for-margin-positive-vulvar-squamous-cell-carcinoma-defining-the-ideal-dose-response-using-the-national-cancer-data-base
#8
Bhavana V Chapman, Beant S Gill, Akila N Viswanathan, Goundappa K Balasubramani, Paniti Sukumvanich, Sushil Beriwal
PURPOSE: Positive surgical margins after radical vulvectomy for vulvar cancer portend a high risk for local relapse, which may be challenging to salvage. We assessed the impact of adjuvant radiation therapy (aRT) on overall survival (OS) and the dose-response relationship using the National Cancer Data Base. METHODS AND MATERIALS: Patients with vulvar squamous cell carcinoma who underwent initial extirpative surgery with positive margins from 1998 to 2012 were included...
September 24, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27843034/intensity-modulated-radiation-therapy-with-simultaneous-integrated-boost-in-patients-with-brain-oligometastases-a-phase-1-study-iside-bm-1
#9
Marica Ferro, Silvia Chiesa, Gabriella Macchia, Savino Cilla, Federica Bertini, Giovanni Frezza, Andrea Farioli, Silvia Cammelli, Mario Balducci, Anna Ianiro, Anna Lisa Angelini, Gaetano Compagnone, Vincenzo Valentini, Francesco Deodato, Alessio G Morganti
PURPOSE: To investigate the maximum tolerated dose of intensity modulated radiation therapy simultaneous integrated boost whole-brain radiation therapy for palliative treatment of patients with <5 brain metastases using a standard linear accelerator. MATERIALS AND METHODS: The whole brain plus 3-mm margin was defined as the planning target volume (PTVwb), whereas each brain metastasis, defined as the contrast-enhancing tumor on MRI T1 scans, plus a 3-mm isotropic margin, was defined as metastases PTV (PTVm)...
September 23, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27838186/temporal-evolution-and-dose-volume-histogram-predictors-of-visual-acuity-after-proton-beam-radiation-therapy-of-uveal-melanoma
#10
Alexei L Polishchuk, Kavita K Mishra, Vivian Weinberg, Inder K Daftari, Jacqueline M Nguyen, Tia B Cole, Jeanne M Quivey, Theodore L Phillips, Devron H Char
PURPOSE: To perform an in-depth temporal analysis of visual acuity (VA) outcomes after proton beam radiation therapy (PBRT) in a large, uniformly treated cohort of uveal melanoma (UM) patients, to determine trends in VA evolution depending on pretreatment and temporally defined posttreatment VA measurements; and to investigate the relevance of specific patient, tumor and dose-volume parameters to posttreatment vision loss. METHODS AND MATERIALS: Uveal melanoma patients receiving PBRT were identified from a prospectively maintained database...
September 23, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27816362/experimental-platform-for-ultra-high-dose-rate-flash-irradiation-of-small-animals-using-a-clinical-linear-accelerator
#11
Emil Schüler, Stefania Trovati, Gregory King, Frederick Lartey, Marjan Rafat, Manuel Villegas, A Joe Praxel, Billy W Loo, Peter G Maxim
PURPOSE: A key factor limiting the effectiveness of radiation therapy is normal tissue toxicity, and recent preclinical data have shown that ultra-high dose rate irradiation (>50 Gy/s, "FLASH") potentially mitigates this effect. However, research in this field has been strongly limited by the availability of FLASH irradiators suitable for small animal experiments. We present a simple methodologic approach for FLASH electron small animal irradiation with a clinically available linear accelerator (LINAC)...
September 20, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27816361/genetic-variants-in-cd44-and-mat1a-confer-susceptibility-to-acute-skin-reaction-in-breast-cancer-patients-undergoing-radiation-therapy
#12
Kamalesh Dattaram Mumbrekar, Satish Rao Bola Sadashiva, Shama Prasada Kabekkodu, Donald Jerard Fernandes, Bejadi Manjunath Vadhiraja, Tomo Suga, Yoshimi Shoji, Fumiaki Nakayama, Takashi Imai, Kapaettu Satyamoorthy
PURPOSE: Heterogeneity in radiation therapy (RT)-induced normal tissue toxicity is observed in 10% of cancer patients, limiting the therapeutic outcomes. In addition to treatment-related factors, normal tissue adverse reactions also manifest from genetic alterations in distinct pathways majorly involving DNA damage-repair genes, inflammatory cytokine genes, cell cycle regulation, and antioxidant response. Therefore, the common sequence variants in these radioresponsive genes might modify the severity of normal tissue toxicity, and the identification of the same could have clinical relevance as a predictive biomarker...
September 20, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27816360/does-peer-review-of-radiation-plans-affect-clinical-care-a-systematic-review-of-the-literature
#13
Kelsey Brunskill, Timothy K Nguyen, R Gabriel Boldt, Alexander V Louie, Andrew Warner, Lawrence B Marks, David A Palma
PURPOSE: Peer review is a recommended component of quality assurance in radiation oncology; however, it is resource-intensive and its effect on patient care is not well understood. We conducted a systematic review of the published data to assess the reported clinical impact of peer review on radiation treatment plans. METHODS AND MATERIALS: A systematic review of published English studies was performed in accordance with the PRISMA guidelines using the MEDLINE and EMBASE databases and abstracts published from major radiation oncology scientific meeting proceedings...
September 20, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27843035/consensus-contouring-guidelines-for-postoperative-stereotactic-body-radiation-therapy-for-metastatic-solid-tumor-malignancies%C3%A2-to-the-spine
#14
Kristin J Redmond, Scott Robertson, Simon S Lo, Scott G Soltys, Samuel Ryu, Todd McNutt, Samuel T Chao, Yoshiya Yamada, Amol Ghia, Eric L Chang, Jason Sheehan, Arjun Sahgal
PURPOSE: To develop consensus contouring guidelines for postoperative stereotactic body radiation therapy (SBRT) for spinal metastases. METHODS AND MATERIALS: Ten spine SBRT specialists representing 10 international centers independently contoured the clinical target volume (CTV), planning target volume (PTV), spinal cord, and spinal cord planning organ at risk volume (PRV) for 10 representative clinical scenarios in postoperative spine SBRT for metastatic solid tumor malignancies...
September 17, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27816365/patterns-of-care-in-proton-radiation-therapy-for-pediatric-central-nervous-system-malignancies
#15
Bismarck Odei, Jonathan E Frandsen, Dustin Boothe, Ralph P Ermoian, Matthew M Poppe
PURPOSE: Proton beam therapy (PBT) potentially allows for improved sparing of normal tissues, hopefully leading to decreased late side effects in children. Using a national registry, we sought to perform a patterns-of-care analysis for children receiving PBT for primary malignancies of the central nervous system (CNS). METHODS AND MATERIALS: Using the National Cancer Data Base, we identified pediatric patients with primary CNS malignancies that were diagnosed between 2004 and 2012...
September 17, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27816363/patterns-of-primary-tumor-invasion-and-regional-lymph-node-spread-based-on-magnetic-resonance-imaging-in-early-stage-nasal-nk-t-cell-lymphoma-implications-for-clinical-target-volume-definition-and-prognostic-significance
#16
Run-Ye Wu, Kang Liu, Wei-Hu Wang, Jing Jin, Yong-Wen Song, Shu-Lian Wang, Yue-Ping Liu, Hua Ren, Hui Fang, Qing-Feng Liu, Yong Yang, Bo Chen, Shu-Nan Qi, Ning-Ning Lu, Yu Tang, Yuan Tang, Ning Li, Han Ouyang, Ye-Xiong Li
PURPOSE: This study aimed to determine the pathways of primary tumor invasion (PTI) and regional lymph node (LN) spread based on magnetic resonance imaging (MRI) in early-stage nasal NK/T-cell lymphoma (NKTCL), to improve clinical target volume (CTV) delineation and evaluate the prognostic value of locoregional extension patterns. METHODS AND MATERIALS: A total of 105 patients with newly diagnosed early-stage nasal NKTCL who underwent pretreatment MRI were retrospectively reviewed...
September 17, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27816364/in%C3%A2-vivo-imaging-reveals-significant-tumor-vascular-dysfunction-and-increased-tumor-hypoxia-inducible-factor-1%C3%AE-expression-induced-by-high-single-dose-irradiation-in-a-pancreatic-tumor-model
#17
Azusa Maeda, Yonghong Chen, Jiachuan Bu, Hilda Mujcic, Bradly G Wouters, Ralph S DaCosta
PURPOSE: To investigate the effect of high-dose irradiation on pancreatic tumor vasculature and microenvironment using in vivo imaging techniques. METHODS AND MATERIALS: A BxPC3 pancreatic tumor xenograft was established in a dorsal skinfold window chamber model and a subcutaneous hind leg model. Tumors were irradiated with a single dose of 4, 12, or 24 Gy. The dorsal skinfold window chamber model was used to assess tumor response, vascular function and permeability, platelet and leukocyte adhesion to the vascular endothelium, and tumor hypoxia for up to 14 days after 24-Gy irradiation...
September 14, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27869098/radiation-dose-escalation-in-esophageal-cancer-revisited-a-contemporary-analysis-of-the-national-cancer-data-base-2004-to-2012
#18
Jeffrey V Brower, Shuai Chen, Michael F Bassetti, Menggang Yu, Paul M Harari, Mark A Ritter, Andrew M Baschnagel
PURPOSE: To evaluate the effect of radiation dose escalation on overall survival (OS) for patients with nonmetastatic esophageal cancer treated with concurrent radiation and chemotherapy. METHODS AND MATERIALS: Patients diagnosed with stage I to III esophageal cancer treated from 2004 to 2012 were identified from the National Cancer Data Base. Patients who received concurrent radiation and chemotherapy with radiation doses of ≥50 Gy and did not undergo surgery were included...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27869097/the-impact-of-radiation-treatment-time-on-survival-in-patients-with-head-and-neck-cancer
#19
Talha Shaikh, Elizabeth A Handorf, Colin T Murphy, Ranee Mehra, John A Ridge, Thomas J Galloway
PURPOSE: To assess the impact of radiation treatment time (RTT) in head and neck cancers on overall survival (OS) in the era of chemoradiation. METHODS AND MATERIALS: Patients with diagnoses of tongue, hypopharynx, larynx, oropharynx, or tonsil cancer were identified by use of the National Cancer Database. RTT was defined as date of first radiation treatment to date of last radiation treatment. In the definitive setting, prolonged RTT was defined as >56 days, accelerated RTT was defined as <47 days, and standard RTT was defined as 47 to 56 days...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27869096/predictive-factor-analysis-of-response-adapted-radiation-therapy-for-chemotherapy-sensitive-pediatric-hodgkin-lymphoma-analysis-of-the-children-s-oncology-group-ahod-0031-trial
#20
Anne-Marie Charpentier, Debra L Friedman, Suzanne Wolden, Cindy Schwartz, Bethany Gill, Jenna Sykes, Alisha Albert-Green, Kara M Kelly, Louis S Constine, David C Hodgson
PURPOSE: To evaluate whether clinical risk factors could further distinguish children with intermediate-risk Hodgkin lymphoma (HL) with rapid early and complete anatomic response (RER/CR) who benefit significantly from involved-field RT (IFRT) from those who do not, and thereby aid refinement of treatment selection. METHODS AND MATERIALS: Children with intermediate-risk HL treated on the Children's Oncology Group AHOD 0031 trial who achieved RER/CR with 4 cycles of chemotherapy, and who were randomized to 21-Gy IFRT or no additional therapy (n=716) were the subject of this study...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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