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International Journal of Radiation Oncology, Biology, Physics

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https://www.readbyqxmd.com/read/29100787/facility-volume-and-survival-in-nasopharyngeal-carcinoma
#1
Emi J Yoshida, Michael Luu, John M David, Sungjin Kim, Alain Mita, Kevin Scher, Stephen L Shiao, Mourad Tighiouart, Nancy Y Lee, Allen S Ho, Zachary S Zumsteg
INTRODUCTION: Definitive treatment of nasopharyngeal carcinoma (NPC) is challenging owing to its rarity, complicated regional anatomy, and the intensity of therapy. In contrast to other head and neck cancers, the effect of facility volume has not been well described for NPC. METHODS AND MATERIALS: The National Cancer Database was queried for patients with stage II-IVB NPC diagnosed from 2004 to 2014 and treated with definitive radiation. Patients with incomplete staging, unknown receipt or timing of treatment, unknown follow-up duration, incomplete socioeconomic information, or treatment outside the reporting facility were excluded...
September 28, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29102647/the-transcriptional-landscape-of-radiation-treated-human-prostate-cancer-analysis-of-a-prospective-tissue-cohort
#2
Simon P Keam, Franco Caramia, Cristina Gamell, Piotr J Paul, Gisela Mir Arnau, Paul J Neeson, Scott G Williams, Ygal Haupt
PURPOSE: The resistance of prostate cancer to radiation therapy (RT) is a significant clinical issue and still largely unable to be guided by patient-specific molecular characteristics. The present study describes the gene expression changes induced in response to RT in human prostate tissue obtained from a prospective tissue acquisition study designed for radiobiology research. METHODS AND MATERIALS: A prospective cohort of 5 men with intermediate-risk and clinically localized tumors were treated with high-dose-rate brachytherapy with 2 × 10-Gy fractions...
September 25, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29102279/microdosimetric-evaluation-of-current-and-alternative-brachytherapy-sources-a-geant4-dna-simulation-study
#3
Gabriel Famulari, Piotr Pater, Shirin A Enger
PURPOSE: Radioisotopes such as (75)Se, (169)Yb, and (153)Gd have photon energy spectra and half-lives that make them excellent candidates as alternatives to (192)Ir for high-dose-rate brachytherapy. The aim of the present study was to evaluate the relative biological effectiveness (RBE) of current ((192)Ir, (125)I, (103)Pd) and alternative ((75)Se, (169)Yb, (153)Gd) brachytherapy radionuclides using Monte Carlo simulations of lineal energy distributions. METHODS AND MATERIALS: Brachytherapy sources (microSelectron v2 [(192)Ir, (75)Se, (169)Yb, (153)Gd], SelectSeed [(125)I], and TheraSeed [(103)Pd]) were placed in the center of a spherical water phantom with a radius of 40 cm using the Geant4 Monte Carlo simulation toolkit...
September 25, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29100788/deep-inspiration-breath-hold-intensity-modulated-radiation-therapy-to-the-mediastinum-for-lymphoma-patients-setup-uncertainties-and-margins
#4
Michalis Aristophanous, Pai-Chun M Chi, Jeremy Kao, Ryan Williamson, Sam Tung, Therese Andraos, Sarah A Milgrom, Chelsea C Pinnix, Bouthaina S Dabaja
PURPOSE: Patient setup for treating large target volumes can be challenging. In the present study, we measured the local uncertainties in the treatment of mediastinal lymphoma and investigated the need for region-specific planning target volume (PTV) margins. METHODS AND MATERIALS: The data from 30 patients who had undergone radiation therapy for mediastinal lymphoma were retrospectively analyzed. A computed tomography (CT)-on-rails (CTOR) system in the treatment room was used for daily image guidance...
September 25, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29128147/using-indocyanine-green-extraction-to-predict-liver-function-after-stereotactic-body-radiation-therapy-for-hepatocellular-carcinoma
#5
Krithika Suresh, Dawn Owen, Latifa Bazzi, William Jackson, Randall K Ten Haken, Kyle Cuneo, Mary Feng, Theodore S Lawrence, Matthew J Schipper
PURPOSE: To test the hypothesis that mid-treatment measures of the retention of indocyanine green after 15 minutes (ICGR15) would improve the prediction of posttreatment liver function in the setting of hepatocellular carcinoma. METHODS AND MATERIALS: Between 2006 and 2015, 144 patients with hepatocellular carcinoma received 175 courses of stereotactic body radiation therapy (SBRT). Patient data, such as age, sex, portal vein thrombosis, cirrhosis, Child-Pugh (CP) score, prior liver-directed therapies, and liver function tests, including albumin-bilirubin (ALBI) and ICG clearance, and dosimetric data, such as tumor volume and radiation dose, were collected...
September 22, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29107335/analysis-of-chromatin-opening-in-heterochromatic-non-small-cell-lung-cancer-tumor-initiating-cells-in-relation-to-dna-damaging-antitumor-treatment
#6
Mina Eriksson, Petra Hååg, Beata Brzozowska, Magdalena Lipka, Halina Lisowska, Rolf Lewensohn, Andrzej Wojcik, Kristina Viktorsson, Lovisa Lundholm
PURPOSE: We previously reported that sphere-forming non-small cell lung cancer (NSCLC) tumor-initiating cells (TICs) have an altered activation of DNA damage response- and repair proteins and are refractory to DNA-damaging treatments. We analyzed whether chromatin organization plays a role in the observed refractoriness. METHODS AND MATERIALS: Bulk cells and TICs from the NSCLC H23 and H1299 cell lines were examined using cell viability, clonogenic survival, Western blot, short interfering RNA analysis, and micronucleus assay...
September 22, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29102278/incidence-of-high-risk-radiologic-features-in-patients-without-local-recurrence-after-stereotactic-ablative-radiation-therapy-for-early-stage-non-small-cell-lung-cancer
#7
M I Ronden, J R van Sörnsen de Koste, C Johnson, B J Slotman, F O B Spoelstra, C J A Haasbeek, G Blom, E M Bongers, A Warner, A Ward, D Palma, S Senan
PURPOSE: To investigate, in the setting of stereotactic ablative radiation therapy (SABR) for early-stage non-small cell lung cancer, the incidence and patterns of change in high-risk radiologic features (HRFs) in patients known to have no local recurrence. METHODS AND MATERIALS: Computed tomography (CT) scans of patients treated using volumetric modulated arc therapy SABR between 2008 and 2013 were eligible if follow-up scans were available for 2 years and no local recurrences were diagnosed...
September 22, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29102276/effect-of-cd4-count-on-treatment-toxicity-and-tumor-recurrence-in-human-immunodeficiency-virus-positive-patients-with-anal-cancer
#8
Alex K Bryant, Ross Mudgway, Minh-Phuong Huynh-Le, Daniel R Simpson, Loren K Mell, Samir Gupta, Andrew B Sharabi, James D Murphy
PURPOSE: To study the effects of immunosuppression on treatment toxicity, long-term cancer recurrence risk, and survival among human immunodeficiency virus (HIV)-positive anal cancer patients. METHODS AND MATERIALS: From a nationwide retrospective cohort of veterans with anal cancer we identified 142 HIV-positive patients with stage I-III disease, diagnosed between 2000 and 2015 and treated with definitive-intent chemotherapy and radiation. We used regression models to study the impact of pretreatment CD4 counts and longitudinal posttreatment CD4 counts on outcomes including acute toxicity, long-term ostomy rates, cancer recurrence, cancer-specific survival, and overall survival...
September 22, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29102277/short-term-follow-up-mammography-in-breast-conservation-therapy-likely-leads-to-unnecessary-downstream-workup-a-longitudinal-study
#9
Shaakir Hasan, Stephen Abel, LaShondria Simpson-Camp, Meredith Witten, Luis Aguilera, Leslie Teng, Frances Hite Philp, Thomas B Julian, Mark Trombetta, Stephen Karlovits, Michael Cowher
PURPOSE: To analyze the effect of post-radiation therapy (XRT) mammographic timing and radiation technique in relation to additional downstream workup for 569 breast conservation therapy patients treated with adjuvant XRT after their initial surveillance mammogram (MMG). METHODS AND MATERIALS: From January 2011 to December 2014, 569 breast cancer patients treated with breast conservation surgery and adjuvant XRT with a follow-up MMG were reviewed. Patients were stratified by the time interval until their first post-XRT MMG, and by XRT technique-whole breast (472), accelerated partial breast (96), conventional fractionation (373), hypofractionation (94), surgical cavity boosts (407), or no boost (66)...
September 21, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29066122/comparing-the-effectiveness-of-combined-external-beam-radiation-and-hyperthermia-versus-external-beam-radiation-alone-in-treating-patients-with-painful-bony-metastases-a-phase-3-prospective-randomized-controlled-trial
#10
Mau-Shin Chi, Kai-Lin Yang, Yue-Cune Chang, Hui-Ling Ko, Yi-Hsien Lin, Su-Chen Huang, Yi-Ying Huang, Kuang-Wen Liao, Motoharu Kondo, Kwan-Hwa Chi
PURPOSE: To compare the response, duration of pain relief, and time to achieve complete pain relief after radiation therapy (RT) with or without hyperthermia (HT) in patients with painful bony metastases. METHODS AND MATERIALS: Cancer patients with bony metastases and pain score ≥4 on the Brief Pain Inventory (BPI) were randomized to RT of 30 Gy in 10 fractions combined with HT (RT + HT) versus RT alone. Hyperthermia was performed by the Thermotron RF-8, with maintenance of the target temperature for 40 minutes per treatment within 2 hours after RT, twice weekly for 2 weeks...
September 21, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29029884/identification-of-atic-as-a-novel-target-for-chemoradiosensitization
#11
Xiangfei Liu, Uma Devi Paila, Sharon N Teraoka, Jocyndra A Wright, Xin Huang, Aaron R Quinlan, Richard A Gatti, Patrick Concannon
PURPOSE: Mutations in the gene encoding 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), a bifunctional enzyme that catalyzes the final 2 steps of the purine de novo biosynthetic pathway, were identified in a subject referred for radiation sensitivity testing. Functional studies were performed to determine whether ATIC inhibition was radiosensitizing and, if so, to elucidate the mechanism of this effect and determine whether small molecule inhibitors of ATIC could act as effective radiosensitizing agents...
September 21, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29066123/deep-inspiration-breath-hold-radiation-therapy-in-breast-cancer-a-word-of-caution-on-the-dose-to-the-axillary-lymph-node-levels
#12
Kai Joachim Borm, Markus Oechsner, Stephanie E Combs, Marciana-Nona Duma
PURPOSE: To assess the differences in unintended regional nodal irradiation between free breathing (FB) and deep inspiration breath hold (DIBH) during tangential field irradiation. METHODS AND MATERIALS: We randomly chose 32 patients from our database who underwent both DIBH and FB treatment planning. Contouring of the axillary lymph node levels (LI, LII, and LIII) was performed retrospectively according to the Radiation Therapy Oncology Group contouring atlas...
September 20, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29066119/concurrent-chemoradiotherapy-in-curatively-resected-gallbladder-carcinoma-a-propensity-score-matched-analysis
#13
Benxing Gu, Liwen Qian, Hong Yu, Jianbin Hu, Qi Wang, Jingjing Shan, Liming Shi, Hai Liu, Qichu Yang, Xiao Liang, Xiujun Cai, Xiaonan Sun
PURPOSE: To compare overall survival (OS) between patients receiving radical resection followed by concurrent chemoradiotherapy (S+CCRT) and patients receiving radical resection only (S) for advanced resectable gallbladder carcinoma (GBC). METHODS AND MATERIALS: Ninety-four GBC patients with stage pT2-4, N0-1, and M0 consented to inclusion in a clinical database from June 2003 to July 2013. Patients who received S+CCRT were matched by propensity score with those who received S through nearest-neighbor matching, with a caliper width of 0...
September 20, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29079119/evaluation-of-stopping-power-prediction-by-dual-and-single-energy-computed-tomography-in-an-anthropomorphic-ground-truth-phantom
#14
Patrick Wohlfahrt, Christian Möhler, Christian Richter, Steffen Greilich
PURPOSE: To determine the accuracy of particle range prediction for proton and heavier ion radiation therapy based on dual-energy computed tomography (DECT) in a realistic inhomogeneous geometry and to compare it with the state-of-the-art clinical approach. METHODS AND MATERIALS: A 3-dimensional ground-truth map of stopping-power ratios (SPRs) was created for an anthropomorphic head phantom by assigning measured SPR values to segmented structures in a high-resolution CT scan...
September 18, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29066124/population-based-study-of-stereotactic-radiosurgery-or-fractionated-stereotactic-radiation-therapy-for-vestibular-schwannoma-long-term-outcomes-and-toxicities
#15
Andrea Lo, Gareth Ayre, Roy Ma, Fred Hsu, Ryojo Akagami, Michael McKenzie, Boris Valev, Ermias Gete, Isabelle Vallieres, Alan Nichol
PURPOSE: To examine long-term local control of vestibular schwannoma and side effects in patients treated with stereotactic radiosurgery (SRS) and fractionated stereotactic radiation therapy (SRT) in British Columbia. METHODS AND MATERIALS: From August 1998 to May 2009, 207 patients were treated with radiation therapy (RT) at British Columbia Cancer Agency. 136 (66%) received SRS, and 71 (34%) received SRT. Dose prescriptions were 50 Gy/25 fractions for SRT and 12 Gy/1 fraction for SRS...
September 18, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29079120/evaluation-of-delivery-costs-for-external-beam-radiation-therapy-and-brachytherapy-for-locally-advanced-cervical-cancer-using-time-driven-activity-based-costing
#16
Kristine Bauer-Nilsen, Colin Hill, Daniel M Trifiletti, Bruce Libby, Donna H Lash, Melody Lain, Deborah Christodoulou, Constance Hodge, Timothy N Showalter
PURPOSE: To evaluate the delivery costs, using time-driven activity-based costing, and reimbursement for definitive radiation therapy for locally advanced cervical cancer. METHODS AND MATERIALS: Process maps were created to represent each step of the radiation treatment process and included personnel, equipment, and consumable supplies used to deliver care. Personnel were interviewed to estimate time involved to deliver care. Salary data, equipment purchasing information, and facilities costs were also obtained...
September 14, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29066120/stereotactic-body-radiation-therapy-as-an-alternative-to-transarterial-chemoembolization-for-hepatocellular-carcinoma
#17
Eli Sapir, Yebin Tao, Matthew J Schipper, Latifa Bazzi, Paula M Novelli, Pauline Devlin, Dawn Owen, Kyle C Cuneo, Theodore S Lawrence, Neehar D Parikh, Mary Feng
PURPOSE: To conduct a large single-institution comparison of transarterial chemoembolization (TACE) and stereotactic body radiation therapy (SBRT) outcomes in similar groups of patients with hepatocellular carcinoma (HCC). METHODS AND MATERIALS: From 2006 to 2014, 209 patients with 1 to 2 tumors underwent TACE (n=84) to 114 tumors or image guided SBRT (n=125) to 173 tumors. Propensity score analysis with inverse probability of treatment weighting was used to compare outcomes between treatments while adjusting for imbalances in treatment assignment...
September 14, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29079118/full-monte-carlo-based-biologic-treatment-plan-optimization-system-for-intensity-modulated-carbon-ion-therapy-on-graphics-processing-unit
#18
Nan Qin, Chenyang Shen, Min-Yu Tsai, Marco Pinto, Zhen Tian, Georgios Dedes, Arnold Pompos, Steve B Jiang, Katia Parodi, Xun Jia
PURPOSE: One of the major benefits of carbon ion therapy is enhanced biological effectiveness at the Bragg peak region. For intensity modulated carbon ion therapy (IMCT), it is desirable to use Monte Carlo (MC) methods to compute the properties of each pencil beam spot for treatment planning, because of their accuracy in modeling physics processes and estimating biological effects. We previously developed goCMC, a graphics processing unit (GPU)-oriented MC engine for carbon ion therapy...
September 12, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29051038/image-guided-radiation-therapy-strategies-for-pelvic-lymph-node-irradiation-in-high-risk-prostate-cancer-motion-and-margins
#19
Lucy Kershaw, Laila van Zadelhoff, Wilma Heemsbergen, Floris Pos, Marcel van Herk
PURPOSE: To quantify the relative motion of the pelvic lymph nodes (LNs), seminal vesicles (SV) and prostate and define indicative margins for image-guided radiotherapy based on bony anatomy or prostate correction strategies for a 3 or 6 degrees-of-freedom couch. METHODS AND MATERIALS: Nineteen patients had a planning computed tomography (CT) scan followed by a mean of 11 repeated CT scans during radiation therapy. The prostate, SV, and external and internal iliac LN regions on the left and right were outlined on each CT scan...
September 8, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29066121/patterns-of-intraosseous-recurrence-after-stereotactic-body-radiation-therapy-for-coxal-bone-metastasis
#20
Kei Ito, Takuya Shimizuguchi, Keiji Nihei, Tomohisa Furuya, Hiroaki Ogawa, Hiroshi Tanaka, Keisuke Sasai, Katsuyuki Karasawa
PURPOSE: To analyze the detailed pattern of intraosseous failure after stereotactic body radiation therapy (SBRT) for coxal bone metastasis. METHODS AND MATERIALS: Patients treated with SBRT to coxal bone metastasis were identified by retrospective chart review. The SBRT doses were 30 Gy or 35 Gy in 5 fractions. A margin of 5 to 10 mm was added to the gross tumor volume to create the clinical target volume. We evaluated the presence or absence of intraosseous recurrence using magnetic resonance imaging...
September 5, 2017: International Journal of Radiation Oncology, Biology, Physics
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