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International Journal of Radiation Oncology, Biology, Physics

Stephanie Dorta-Estremera, Lauren E Colbert, Nookala Sita Mahalakshmi Krishna, Ananta V Yanamandra, Guojun Yang, Andrea Delgado, Megan Mikkelson, Patricia Eifel, Anuja Jhingran, Lilie Lin, James Welsh, Kathleen Schmeler, K Jagannadha Sastry, Ann Klopp
PURPOSE: Radiation therapy (RT) has direct cytotoxic effects on tumor-infiltrating lymphocytes, but also has immune stimulatory effects that increase immune cell infiltration. The dynamics of these competing effects on immune cells at the site of the tumor are poorly characterized during chemoradiation treatment (CRT) due to the difficulty of obtaining consecutive tumor biopsies. We utilized a minimally invasive cervical cytobrushing method to analyze the kinetics of intratumoral immune cell changes in cervical cancer patients during CRT...
July 12, 2018: International Journal of Radiation Oncology, Biology, Physics
Annalisa Patriarca, Charles Fouillade, Michel Auger, Frédéric Martin, Frédéric Pouzoulet, Catherine Nauraye, Sophie Heinrich, Vincent Favaudon, Samuel Meyroneinc, Rémi Dendale, Alejandro Mazal, Philip Poortmans, Pierre Verrelle, Ludovic De Marzi
PURPOSE: Recent in vivo investigations have shown that short pulses (FLASH) of electrons are less harmful to healthy tissues, but just as efficient as conventional dose-rate radiation to inhibit tumor growth. In view of the potential clinical value of FLASH and the availability of modern proton therapy infrastructures to achieve this goal, we herein describe a series of technological developments required to investigate the biology of FLASH irradiation, using a commercially available clinical proton therapy system...
July 11, 2018: International Journal of Radiation Oncology, Biology, Physics
Intae Park, Hannah Yang, Jin-Sung Park, Gou Young Koh, Eun Kyung Choi
PURPOSE: Several clinical trials have combined anti-angiogenic agents and radiotherapy, but evidence of its clinical benefit is insufficient. In this study, we rationalized and investigated the combination of VEGF-Grab, an anti-angiogenic drug that inhibits VEGF-A and PlGF, and radiotherapy for anti-cancer therapy. METHODS AND MATERIALS: To observe for changes in PlGF after radiation, HCT116, HCT15, SW480, BxPC3, and RAW264.7 cells and LLC and BxPC3 tumors were given 10 Gy of radiation and changes in the expression of PlGF were analyzed...
July 11, 2018: International Journal of Radiation Oncology, Biology, Physics
Mai K Bishr, Mohamed S Zaghloul
The access of low- and middle-income countries (LMIC) to radiation facilities is far from optimal. Latin America and Africa represent 55% of LMIC, where radiotherapy facilities are available in only 70% and 46% of the countries, respectively. Only three countries in both regions meet the International Atomic Energy Agency (IAEA) recommendation of 250,000 population per megavoltage machine (MVM). In Africa, the mean population served by one MVM is 3.56 million compared to 0.65 million in Latin America. The distribution of radiation facilities in both regions varies according to the income groups...
July 10, 2018: International Journal of Radiation Oncology, Biology, Physics
Patrick Wohlfahrt, Esther G C Troost, Christian Hofmann, Christian Richter, Annika Jakobi
PURPOSE: Single-source dual-spiral dual-energy computed tomography (DECT) provides additional patient information but is prone to motion between the two consecutively acquired CT scans. Here, the clinical applicability of dual-spiral time-resolved DECT (4D-DECT) for proton treatment planning within the thoracic region was evaluated. METHODS AND MATERIALS: Dual-spiral 4D-DECT scans of three lung-cancer patients were acquired. For time-averaged datasets and four breathing phases, the geometrical conformity of 80 kVp and 140 kVp 4D-DECT scans before image post-processing was assessed by normalized cross correlation (NCC)...
July 9, 2018: International Journal of Radiation Oncology, Biology, Physics
Benjamin S Rosen, Peter G Hawkins, Daniel F Polan, James M Balter, Kristy K Brock, Justin D Kamp, Christina M Lockhart, Avraham Eisbruch, Michelle L Mierzwa, Randall K Ten Haken, Issam El Naqa
PURPOSE: To determine whether serial cone-beam computed tomography (CBCT) images taken during head and neck radiotherapy (HNR) can improve chronic xerostomia prediction METHODS AND MATERIALS: In a retrospective analysis, parotid glands (PGs) were delineated on daily kV CBCT images using deformable image registration (DIR) for 119 HNR patients (60 or 70 Gy in 2 Gy/fraction over 6 or 7 weeks). DIR accuracy for a subset of deformed contours was quantified using the Dice similarity coefficient (DSC) and mean distance-to-agreement (MDA) in comparison to manually drawn contours...
July 9, 2018: International Journal of Radiation Oncology, Biology, Physics
W Jeffrey Petty, James J Urbanic, Tamjeed Ahmed, Ryan Hughes, Beverly Levine, Kyle Rusthoven, Michael Papagikos, Jimmy R Ruiz, Brian E Lally, Michael Chan, Hollins Clark, Ralph B D'Agostino, A William Blackstock
PURPOSE: Recent data indicate consolidative radiation therapy (CRT) improves progression free survival (PFS) for patients with oligometastatic non-small cell lung cancer (NSCLC). Data regarding long term outcomes are limited. METHODS AND MATERIALS: In 2010, this prospective, multi-center, single arm, phase II trial was initiated and enrolled patients with oligometastatic NSCLC. Oligometastatic disease was defined as a maximum number of five metastatic lesions for all disease sites including no more than three active extracranial metastatic lesions...
July 9, 2018: International Journal of Radiation Oncology, Biology, Physics
Michael M Dominello, Judith C Keen, Tyler F Beck, John Bayouth, Jonathan Knisely, David J Carlson, Marc S Mendonca, Omar Mian, Kristy K Brock, Mitchell Anscher, Geoffrey Hugo, Eduardo G Moros, Anurag K Singh, James B Yu
No abstract text is available yet for this article.
July 9, 2018: International Journal of Radiation Oncology, Biology, Physics
Chia-Lin Tseng, Hany Soliman, Sten Myrehaug, Young K Lee, Mark Ruschin, Eshetu G Atenafu, Mikki Campbell, Pejman Maralani, Victor Yang, Albert Yee, Arjun Sahgal
OBJECTIVES: We report mature outcomes for a cohort of patients with no prior radiation (de novo) to the spine treated with 24 Gy in 2 daily fractions for metastases, which represents the SBRT regimen under evaluation on the current SC-24 phase 3 randomized trial (NCT02512965). METHODS: The cohort consisted of 279 de novo spinal metastases in 145 consecutive patients treated with 24 Gy in 2 SBRT fractions, identified from a prospective single-institution database...
July 9, 2018: International Journal of Radiation Oncology, Biology, Physics
Grace C Blitzer, Stephen A Rosenberg, Bethany M Anderson, Timothy M McCulloch, Aaron M Wieland, Gregory K Hartig, Justine Y Bruce, Matthew E Witek, Randall J Kimple, Paul M Harari
No abstract text is available yet for this article.
July 3, 2018: International Journal of Radiation Oncology, Biology, Physics
Alessandro Cicchetti, Barbara Avuzzi, Federica Palorini, Francesca Ballarini, Claudio Stucchi, Giovanni Fellin, Pietro Gabriele, Vittorio Vavassori, Claudio Degli Esposti, Cesare Cozzarini, Claudio Fiorino, Tiziana Rancati, Riccardo Valdagni
PURPOSE: This study aimed to validate a previously published predictive model for late fecal incontinence (FI) in a contemporary population of prostate cancer patients treated with radical radiation therapy. METHODS AND MATERIALS: The validation included patients treated with intensity-modulated radiation therapy (IMRT) (2010-2014). Prescribed dose range was 65-80 Gy, including conventional and moderate hypo-fractionated treatments. Rectal toxicity was scored using LENT/SOMA, a minimum 2-year follow up was considered...
June 30, 2018: International Journal of Radiation Oncology, Biology, Physics
Alexander J Lin, Caressa Hui, Sonika Dahiya, Hsiang-Chih Lu, Albert H Kim, Jian L Campian, Christina Tsien, Gregory J Zipfel, Keith M Rich, Michael Chicoine, Jiayi Huang
PURPOSE: To evaluate the clinical outcomes of reirradiation of recurrent meningiomas and factors related to patient selection and treatment modality. METHODS AND MATERIALS: Recurrent meningioma patients who failed prior stereotactic radiosurgery (SRS) or fractionated external beam radiation therapy (EBRT) received reirradiation using either SRS or EBRT. Complete response (CR), partial response (PR), and progression after reirradiation were evaluated using the MacDonald criteria...
June 30, 2018: International Journal of Radiation Oncology, Biology, Physics
Robert H Press, Hui-Kuo G Shu, Hyunsuk Shim, James M Mountz, Brenda F Kurland, Richard L Wahl, Ella F Jones, Nola M Hylton, Elizabeth R Gerstner, Robert J Nordstrom, Lori Henderson, Karen A Kurdziel, Bhadrasain Vikram, Michael A Jacobs, Matthias Holdhoff, Edward Taylor, David A Jaffray, Lawrence H Schwartz, David A Mankoff, Paul E Kinahan, Hannah M Linden, Philippe Lambin, Thomas J Dilling, Daniel L Rubin, Lubomir Hadjiiski, John M Buatti
Modern radiation therapy is delivered with great precision, in part by relying on high-resolution multi-dimensional anatomical imaging to define targets in space and time. The development of quantitative imaging (QI) modalities capable of monitoring biologic parameters has the potential to provide deeper insight into tumor biology and facilitate more personalized clinical decision-making. The Quantitative Imaging Network (QIN) was established by the National Cancer Institute (NCI) to advance and validate these QI modalities in the context of oncology clinical trials, emphasizing the great clinical need for this technology...
June 29, 2018: International Journal of Radiation Oncology, Biology, Physics
Christoph Speier, Giampaolo Pileggi, David Izquierdo-Garcia, Ciprian Catana, Gregory Sharp, Maria Francesca Spadea, Christoph Bert, Joao Seco
PURPOSE: To investigate advanced multi-modal methods for pseudo-CT generation from standard MRI sequences and to validate the results by IMRT and VMAT radiation therapy plans. We present two novel methods which employ key techniques to enhance pseudo-CTs and we investigate the impact on image quality and applicability for IMRT and VMAT therapy planning. MATERIALS AND METHODS: The dataset contains CTs and MRIs from 15 patients who underwent cranial radiotherapy. For each patient pseudo-CTs of the head were generated with a patch-based and a voxel-based algorithm...
June 29, 2018: International Journal of Radiation Oncology, Biology, Physics
J Wasiak, D G Hamilton, F Foroudi, C M Faggion
OBJECTIVE: The purpose of this study was to characterize retracted studies within the field of radiation oncology. METHODS: Computerized searches were performed in Ovid MEDLINE, PubMed, Ovid EMBASE and The Cochrane Library through to May 2017 looking for retracted studies using the terms 'retraction note', 'retracted note', 'withdrawn' and 'radiotherapy', 'radiation oncology'. Additional studies were identified by hand-searching 10 discipline-specific journals. Two authors independently screened papers, and then extracted author demographics, journal characteristics and retraction-specific variables...
June 28, 2018: International Journal of Radiation Oncology, Biology, Physics
Jonathan D Schoenfeld, Evisa Gjini, Scott J Rodig, Roy B Tishler, Bhupendra Rawal, Paul J Catalano, Ravindra Uppaluri, Robert I Haddad, Glenn J Hanna, Nicole G Chau, Guilherme Rabinowits, Jochen Lorch, Vickie Y Jo, Jeffrey F Krane, Laura A Goguen, Donald J Annino, Sara Abdelrahman, Mikel Lipschitz, Danielle N Margalit
PURPOSE: Programmed death-1 (PD-1) inhibitors are approved for the treatment of patients with recurrent and metastatic squamous cell carcinoma of the head and neck (SCCHN). Ongoing and planned randomized phase 3 trials are testing the benefit of combining PD-1/programmed death-ligand 1 (PD-L1) inhibitors with chemoradiation for patients with locoregionally confined SCCHN. Few studies have investigated relationships among potential predictive pathologic biomarkers such as PD-L1, PD-L2, and PD-1 in this population and associations between these markers and clinical characteristics...
June 27, 2018: International Journal of Radiation Oncology, Biology, Physics
Sweet Ping Ng, Jason M Johnson, G Brandon Gunn, David I Rosenthal, Heath D Skinner, Jack Phan, Steven J Frank, William Morrison, Erich M Sturgis, Frank E Mott, Michelle D Williams, Clifton D Fuller, Adam S Garden
INTRODUCTION: Patients with p16/HPV-associated oropharyngeal squamous cell carcinoma have a favorable outcome after treatment. In this group of patients who potentially have a long life expectancy, the optimal surveillance strategy and modality is not well established. We aim to determine the ability of a negative post-radiation PET/CT scan in predicting the risk of subsequent relapse in these patients. MATERIALS/METHODS: A retrospective analysis of patients with p16/HPV-associated oropharyngeal squamous cell carcinoma who completed definitive (chemo)radiotherapy and had a post-treatment PET/CT scan from 2006 to 2013 was performed...
June 27, 2018: International Journal of Radiation Oncology, Biology, Physics
Hajime Tanaka, Soichiro Yoshida, Fumitaka Koga, Kazuma Toda, Ryoichi Yoshimura, Yutaka Nakajima, Emiko Sugawara, Takumi Akashi, Yuma Waseda, Masaharu Inoue, Toshiki Kijima, Minato Yokoyama, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Kazunori Kihara, Yasuhisa Fujii
PURPOSE: Bladder-sparing strategy is a useful option for patients with muscle-invasive bladder cancer (MIBC), in which the response to chemoradiotherapy (CRT) is primarily important in achieving favorable oncological outcomes. Our objective is to evaluate the impact of immunohistochemistry (IHC)-based subtyping in MIBC on prediction of CRT-response. MATERIALS AND METHODS: Treatment protocol consisted of induction CRT followed by partial/radical cystectomy as consolidative surgery; 118 eligible patients with non-metastatic MIBC were retrospectively analyzed...
June 27, 2018: International Journal of Radiation Oncology, Biology, Physics
Shearwood McClelland, Jerry J Jaboin
INTRODUCTION: Pre-residency peer reviewed publications (PRP) have been associated with resident choice of academic versus private practice careers in both neurosurgery and radiation oncology. The relationship between PRP and subsequent citation-based scholarly activity of radiation oncology residents has not been previously examined. METHODS: A list of 2016 radiation oncology resident graduates (163 residents from 76 Accreditation Council for Graduate Medical Education-certified programs) and their PRP were compiled...
June 27, 2018: International Journal of Radiation Oncology, Biology, Physics
Ping Han, Xiaolin Wang, Faya Liang, Yimin Liu, Xingsheng Qiu, Yaodong Xu, Renhui Chen, Shitong Yu, Xiaoming Huang
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a type of malignancy with a high prevalence in southern China and Southeast Asia. The primary treatment modality is radiotherapy (RT). Osteoradionecrosis (ORN) of the skull base remains one of the most serious complications after RT, affecting survival time and quality of life. Thus far, skull base ORN has been seldom reported and can be difficult to distinguish and easy to misdiagnose. In this retrospective study, we report the incidence of skull base ORN and analyze its associated factors in an attempt to decrease the occurrence of ORN...
June 27, 2018: International Journal of Radiation Oncology, Biology, Physics
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