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Diverse assays from a single skin punch biopsy to assess topical drug intervention.
British Journal of Dermatology 2018 October 27
SIR-The development of targeted topical treatments for inherited skin tumour syndromes such as naevoid basal cell carcinoma syndrome is desirable because it avoids surgery and is unlikely to cause systemic side effects.1 However in CYLD cutaneous syndrome (CCS; syn. Brooke-Spiegler syndrome), transgenic mouse models fail to recapitulate the human phenotype,2 hampering similar translational advances for these patients. Research methodologies that offer drug penetration data as well as evidence of "on-target" drug effects in human topically treated CCS tumour samples are informative in the absence of relevant mouse models. Here we describe such a method, employing serial sections of human skin tumour punch biopsies, which is relevant to the study of topical interventions in CCS and can be used in other skin diseases. This article is protected by copyright. All rights reserved.
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