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Intensive Care Medicine

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https://www.readbyqxmd.com/read/28444409/diagnostic-work-up-and-specific-causes-of-acute-kidney-injury
#1
REVIEW
Michael Darmon, Marlies Ostermann, Jorge Cerda, Meletios A Dimopoulos, Lui Forni, Eric Hoste, Matthieu Legrand, Nicolas Lerolle, Eric Rondeau, Antoine Schneider, Bertrand Souweine, Miet Schetz
Acute kidney injury (AKI) is common in critically ill patients and associated with grim short- and long-term outcome. Although in the vast majority of cases AKI is multifactorial, with sepsis, shock and nephrotoxicity accounting for most episodes, specific causes of AKI are not uncommon. Despite remaining uncertainties regarding their prevalence in the ICU, prompt recognition of specific aetiologies of AKI is likely to ensure timely management, limit worsening of renal dysfunction, and ultimately limit renal and systemic consequences of AKI...
April 25, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28439646/critical-care-admission-following-elective-surgery-was-not-associated-with-survival-benefit-prospective-analysis-of-data-from-27-countries
#2
Brennan C Kahan, Desponia Koulenti, Kostoula Arvaniti, Vanessa Beavis, Douglas Campbell, Matthew Chan, Rui Moreno, Rupert M Pearse
PURPOSE: As global initiatives increase patient access to surgical treatments, there is a need to define optimal levels of perioperative care. Our aim was to describe the relationship between the provision and use of critical care resources and postoperative mortality. METHODS: Planned analysis of data collected during an international 7-day cohort study of adults undergoing elective in-patient surgery. We used risk-adjusted mixed-effects logistic regression models to evaluate the association between admission to critical care immediately after surgery and in-hospital mortality...
April 25, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28439645/-permissive-hypercapnia-in-ards-is-it-pass%C3%A3
#3
LETTER
Valliappan Muthu, Ritesh Agarwal, Inderpaul Singh Sehgal, Óscar Peñuelas, N Nin, Alfonso Muriel, Andrés Esteban
No abstract text is available yet for this article.
April 24, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28439644/have-biomarkers-failed-in-acute-kidney-injury-no
#4
EDITORIAL
Blaithin A McMahon, Jay L Koyner
No abstract text is available yet for this article.
April 24, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28439643/have-renal-biomarkers-failed-in-acute-kidney-injury-yes
#5
Jill Vanmassenhove, Jan T Kielstein, Marlies Ostermann
No abstract text is available yet for this article.
April 24, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28439642/have-biomarkers-failed-in-acute-kidney-injury-we-are-not-sure
#6
EDITORIAL
John R Prowle, Mitchell H Rosner
No abstract text is available yet for this article.
April 24, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28434156/paediatric-sepsis-old-wine-in-new-bottles
#7
Luregn J Schlapbach, Etienne Javouhey, Nicolaas J G Jansen
No abstract text is available yet for this article.
April 22, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28424848/glycemic-control-mortality-secondary-infection-and-hypoglycemia-in-critically-ill-pediatric-patients-a-systematic-review-and-network-meta-analysis-of-randomized-controlled-trials
#8
LETTER
Tomohide Yamada, Nobuhiro Shojima, Kazuo Hara, Hisashi Noma, Toshimasa Yamauchi, Takashi Kadowaki
No abstract text is available yet for this article.
April 19, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28421246/immunoglobulin-g-for-patients-with-necrotising-soft-tissue-infection-instinct-a-randomised-blinded-placebo-controlled-trial
#9
Martin B Madsen, Peter B Hjortrup, Marco B Hansen, Theis Lange, Anna Norrby-Teglund, Ole Hyldegaard, Anders Perner
PURPOSE: The aim of the INSTINCT trial was to assess the effect of intravenous polyspecific immunoglobulin G (IVIG) compared with placebo on self-reported physical function in intensive care unit (ICU) patients with necrotising soft tissue infection (NSTI). METHODS: We randomised 100 patients with NSTI 1:1 to masked infusion of 25 g of IVIG (Privigen, CSL Behring) or an equal volume of 0.9% saline once daily for the first 3 days of ICU admission. The primary outcome was the physical component summary (PCS) score of the 36-item short form health survey (SF-36) 6 months after randomisation; patients who had died were given the lowest possible score (zero)...
April 18, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28421245/research-in-community-acquired-pneumonia-the-next-steps
#10
Antoni Torres, Igancio Martín-Loeches, Rosario Menéndez
No abstract text is available yet for this article.
April 18, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28409205/what-s-wrong-in-the-control-of-antimicrobial-resistance-in-critically-ill-patients-from-low-and-middle-income-countries
#11
Arjen M Dondorp, Direk Limmathurotsakul, Elizabeth A Ashley
No abstract text is available yet for this article.
April 13, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28409204/-salvage-treatment-for-infections-by-extensively-and-pan-drug-resistant-pathogens-is-common-and-often-sub-optimal
#12
LETTER
Garyfallia Poulakou, Dimitrios K Matthaiou, Matteo Bassetti, Hakan Erdem, George Dimopoulos, Daniel J Curcio, Jean Carlet, Jeffrey Lipman, Jean-François Timsit, Helen Giamarellou, Angelos Arfaras-Melainis, Jordi Rello
No abstract text is available yet for this article.
April 13, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28409203/the-role-of-infection-models-and-pk-pd-modelling-for-optimising-care-of-critically-ill-patients-with-severe-infections
#13
REVIEW
T Tängdén, V Ramos Martín, T W Felton, E I Nielsen, S Marchand, R J Brüggemann, J B Bulitta, M Bassetti, U Theuretzbacher, B T Tsuji, D W Wareham, L E Friberg, J J De Waele, V H Tam, Jason A Roberts
Critically ill patients with severe infections are at high risk of suboptimal antimicrobial dosing. The pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobials in these patients differ significantly from the patient groups from whose data the conventional dosing regimens were developed. Use of such regimens often results in inadequate antimicrobial concentrations at the site of infection and is associated with poor patient outcomes. In this article, we describe the potential of in vitro and in vivo infection models, clinical pharmacokinetic data and pharmacokinetic/pharmacodynamic models to guide the design of more effective antimicrobial dosing regimens...
April 13, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28393258/intermittent-noninvasive-ventilation-after-extubation-in-patients-with-chronic-respiratory-disorders-a-multicenter-randomized-controlled-trial-vhyper
#14
Frédéric Vargas, Marc Clavel, Pascale Sanchez-Verlan, Sylvain Garnier, Alexandre Boyer, Hoang-Nam Bui, Benjamin Clouzeau, Charline Sazio, Aissa Kerchache, Olivier Guisset, Antoine Benard, Julien Asselineau, Bernard Gauche, Didier Gruson, Stein Silva, Philippe Vignon, Gilles Hilbert
PURPOSE: Early noninvasive ventilation (NIV) after extubation decreases the risk of respiratory failure and lowers 90-day mortality in patients with hypercapnia. Patients with chronic respiratory disease are at risk of extubation failure. Therefore, it could be useful to determine the role of NIV with a discontinuous approach, not limited to patients with hypercapnia. We assessed the efficacy of early NIV in decreasing respiratory failure after extubation in patients with chronic respiratory disorders...
April 9, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28386728/critical-illness-the-brain-is-always-in-the-line-of-fire
#15
EDITORIAL
Martin Smith, Geert Meyfroidt
No abstract text is available yet for this article.
April 6, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28386727/what-s-new-in-pharmacokinetics-of-antimicrobials-in-aki-and-rrt
#16
Jason A Roberts, Jean-Yves Lefrant, Jeffrey Lipman
No abstract text is available yet for this article.
April 6, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28386726/recruitment-maneuvers-using-transpulmonary-pressure-to-help-goldilocks
#17
LETTER
E Baedorf Kassis, S H Loring, D Talmor
No abstract text is available yet for this article.
April 6, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28378124/focus-on-infection-and-sepsis-2017
#18
EDITORIAL
Ignacio Martin-Loeches, Jose Garnacho-Montero, Saad Nseir
No abstract text is available yet for this article.
April 4, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28374098/implementation-of-continuous-qeeg-in-two-neurointensive-care-units-by-intensivists-a-feasibility-study
#19
LETTER
Giuseppe Citerio, Adriana Patruno, Simone Beretta, Luca Longhi, Barbara Frigeni, Luca Lorini
No abstract text is available yet for this article.
April 4, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28374097/performance-and-economic-evaluation-of-the-molecular-detection-of-pathogens-for-patients-with-severe-infections-the-evamica-open-label-cluster-randomised-interventional-crossover-trial
#20
Emmanuelle Cambau, Isabelle Durand-Zaleski, Stéphane Bretagne, Christian Brun Buisson, Catherine Cordonnier, Xavier Duval, Stéphanie Herwegh, Julien Pottecher, René Courcol, Sylvie Bastuji-Garin
PURPOSE: Microbiological diagnosis (MD) of infections remains insufficient. The resulting empirical antimicrobial therapy leads to multidrug resistance and inappropriate treatments. We therefore evaluated the cost-effectiveness of direct molecular detection of pathogens in blood for patients with severe sepsis (SES), febrile neutropenia (FN) and suspected infective endocarditis (SIE). METHODS: Patients were enrolled in a multicentre, open-label, cluster-randomised crossover trial conducted during two consecutive periods, randomly assigned as control period (CP; standard diagnostic workup) or intervention period (IP; additional testing with LightCycler(®)SeptiFast)...
April 3, 2017: Intensive Care Medicine
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