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BMC Nephrology

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https://www.readbyqxmd.com/read/30651091/simultaneous-occurrence-of-igg4-related-tubulointerstitial-nephritis-and-colon-adenocarcinoma-with-hepatic-metastasis-a-case-report-and-literature-review
#1
Shen-Ju Gou, Lu-Jia Xue, Zhang-Xue Hu
BACKGROUND: Understanding the uncommon association of IgG4-related disease with other disorders is essential for the accurate diagnosis and effective treatment of patients. To the best of our knowledge, there have been only few reports of patients with IgG4-related kidney disease coexisting with metastasis of malignancy. Here, we report a rare case of simultaneous occurring IgG4-related tubulointerstitial nephritis and colon adenocarcinoma with hepatic metastasis. CASE PRESENTATION: A 71-year-old Chinese man presented with dysuria and was initially diagnosed as benign prostatic hyperplasia for one year...
January 16, 2019: BMC Nephrology
https://www.readbyqxmd.com/read/30651084/rapid-decline-of-renal-function-in-patients-with-type-2-diabetes-with-heavy-proteinuria-a-report-of-three-cases
#2
Christopher Thiam Seong Lim, Nurul Zaynah Nordin, N Z Fadhlina, M S Anim, T Kalaiselvam, W Z Haikal, Bak Leong Goh
BACKGROUND: Although there is a large volume of literature regarding the definition and epidemiology of. Type 2 diabetes nephropathy (T2DN). There has been a paucity of data focused on the rate of transition of T2 DN. Based on our personal observation a certain percentage of our incident end stage renal disease (ESRD) patients from T2DN experienced a rapid decline of renal function. Their rapid decline nature of glomerular filtration rate (GFR) of 46 to 60 mL/min per 1.73m2 per year have far exceeded the KDIGO definitions of acute kidney injury (abrupt decrease in kidney function occurring over 7 days or less), acute kidney disease (acute or subacute damage and/or loss of kidney function for a duration of between 7 and 90 days after exposure to an acute kidney injury initiating event (Chawla et al Nat Rev Nephrol 241-57 2017) or even rapid decliner (eGFR declines > 5 mL/min per 1...
January 16, 2019: BMC Nephrology
https://www.readbyqxmd.com/read/30651081/identification-of-young-adults-at-risk-of-an-accelerated-loss-of-kidney-function-in-an-area-affected-by-mesoamerican-nephropathy
#3
Marvin Gonzalez-Quiroz, Evangelia-Theano Smpokou, Neil Pearce, Ben Caplin, Dorothea Nitsch
BACKGROUND: After two-years of follow-up of 263 apparently healthy 18- to 30-year-old men in communities affected by Mesoamerican nephropathy (MeN), we identified three distinct case groups: a subgroup with (i) established renal dysfunction (case-group 1); individuals with (ii) a rapid decline in kidney function (case-group 2); and individuals with (iii) stable kidney function (non-cases). This paper investigates whether local tests are potentially useful for the timely identification of these case groups...
January 16, 2019: BMC Nephrology
https://www.readbyqxmd.com/read/30646860/serum-25-hydroxyvitamin-d-were-associated-with-higher-risk-of-both-albuminuria-and-impaired-gfr-incidence-a-cohort-study-based-on-clhls-study
#4
Miao Liu, Jianhua Wang, Yao He
BACKGROUND: This study aimed to examine the relationship between 25-hyfromxyvitamin D (25OHD) and chronic kidney disease (CKD) incidence. METHODS: All the elderly who had participated both in the 2011-2012 survey and 2014 survey in the Chinese Longitudinal Healthy Longevity Survey (CLHLS), and have biomarker data were included in the analysis. We studied those without CKD with complete data at 2011-2012 waves. Serum 25-Hydroxyvitamin D was assessed at baseline. Cox proportional risk model was used to evaluate associations between serum 25-Hydroxyvitamin D and CKD (including both albuminuria and impaired eGFR) incidence after adjusted for potential confounding...
January 15, 2019: BMC Nephrology
https://www.readbyqxmd.com/read/30642279/serum-uric-acid-and-cardiovascular-mortality-in-chronic-kidney-disease-a-meta-analysis
#5
Qimei Luo, Xi Xia, Bin Li, Zhenchuan Lin, Xueqing Yu, Fengxian Huang
BACKGROUND: Conflicting results have been reported from studies evaluating serum uric acid (SUA) levels as an independent risk factor for cardiovascular mortality in patients with chronic kidney disease (CKD). METHODS: We systematically searched MEDLINE, Web of Science, and bibliographies of retrieved articles to identify studies reporting on the association between SUA levels and cardiovascular mortality in patients with CKD. Random-effects models were used to calculate the pooled hazard ratios (HR) and corresponding 95% confidence intervals (CI)...
January 14, 2019: BMC Nephrology
https://www.readbyqxmd.com/read/30642276/bilateral-renal-artery-stenosis-as-a-cause-of-refractory-intradialytic-hypertension-in-a-patient-with-end-stage-renal-disease
#6
Zachary Wolfmueller, Kunal Goyal, Bhanu Prasad
BACKGROUND: We report a 61-year-old female with end-stage renal disease (ESRD) secondary to polycystic kidney disease (PKD) complicated by intradialytic hypertension (IDH). Increased sympathetic drive leading to increased stroke volume and/or vasoconstriction with an inappropriate increase in peripheral vascular resistance (PVR) has been postulated to be the cause of IDH. CASE PRESENTATION: Attempts to control her blood pressure by reducing her goal weight; increasing dialysis times/ frequency and decreasing her sodium concentrate in the dialysis fluid were unsuccessful...
January 14, 2019: BMC Nephrology
https://www.readbyqxmd.com/read/30634947/embolization-of-high-output-idiopathic-renal-arteriovenous-fistula-primarily-using-an-atrial-septal-defect-occluder-via-venous-access-a-case-report
#7
Xiaomao Chen, Qingle Zeng, Peng Ye, Hongfei Miao, Yong Chen
BACKGROUND: The case report is to evaluate the efficacy and safety of embolization of a high-output idiopathic renal arteriovenous fistula (IRAVF) with an atrial septal defect occluder (ASDO) via venous access. CASE PRESENTATION: A 57-year-old male diagnosed with high-output IRAVF received embolization with an ASDO via renal venous access and compact occlusion with 3 vascular plugs and a detachable elastic coil. The IRAVF was successfully occluded. After a follow-up of 2 months, renal arterial computed tomography angiography (CTA) showed the precise location of the ASDO...
January 11, 2019: BMC Nephrology
https://www.readbyqxmd.com/read/30634936/renal-limited-thrombotic-microangiopathy-after-switching-from-bevacizumab-to-ramucirumab-a-case-report
#8
Ryo Yamada, Takao Okawa, Ken Matsuo, Makoto Suzuki, Noriko Mori, Kiyoshi Mori
BACKGROUND: It is well known that vascular endothelial growth factor (VEGF) inhibitors can cause proteinuria. The incidence of proteinuria is high for bevacizumab, a humanized monoclonal antibody directed against VEGF, but the range of proteinuria rarely becomes nephrotic (2.2% occurrence according to a meta-analysis). In such cases, renal pathology shows thrombotic microangiopathy (TMA). Ramucirumab, anti-VEGF receptor 2 (VEGFR2) monoclonal antibody, can also cause proteinuria, but it is not yet reported whether the drug may induce TMA...
January 11, 2019: BMC Nephrology
https://www.readbyqxmd.com/read/30634935/process-based-quality-improvement-using-a-continuous-renal-replacement-therapy-dashboard
#9
Theresa A Mottes, Stuart L Goldstein, Rajit K Basu
BACKGROUND: The prevalence of continuous renal replacement therapy (CRRT) utilization in critically ill patients with acute kidney is increasing. In comparison to published and on-going trials attempting to answer questions surrounding the optimal timing of CRRT initiation, anticoagulation, and modality, a paucity of literature describes the quality of the therapy delivered. METHODS: We conducted a single-center process improvement project to determine if a methodology to assess the quality of CRRT delivery could lead to improvement in CRRT delivery outcomes...
January 11, 2019: BMC Nephrology
https://www.readbyqxmd.com/read/30634931/gut-derived-endotoxin-contributes-to-inflammation-in-severe-ischemic-acute-kidney-injury
#10
Jiangtao Li, Krishna Rekha Moturi, Lirui Wang, Kun Zhang, Chen Yu
BACKGROUND: Recent researches indicate that the intestinal consequences of renal ischemia reperfusion (IR) would predispose to the translocation of gut-derived endotoxin. Here, we designed experiments to test the hypothesis that the gut-derived endotoxin has a potential role in mediating local inflammatory processes in the acutely injured kidney. METHODS: Rats were performed sham or renal IR surgery (60 min of bilateral renal ischemia, then 24 h of reperfusion) (n = 5)...
January 11, 2019: BMC Nephrology
https://www.readbyqxmd.com/read/30630452/a-prospective-observational-study-of-iron-isomaltoside-in-haemodialysis-patients-with-chronic-kidney-disease-treated-for-iron-deficiency-dino
#11
Ashraf I Mikhail, Staffan Schön, Sylvia Simon, Christopher Brown, Jörgen B A Hegbrant, Gert Jensen, Jason Moore, Lennart D I Lundberg
BACKGROUND: Iron deficiency is frequent in haemodialysis (HD) patients with chronic kidney disease (CKD), and intravenous iron is an established therapy for these patients. This study assessed treatment routine, effectiveness, and safety of iron isomaltoside (IIM) 5% (Diafer®) in a HD cohort. METHODS: This prospective observational study included 198 HD patients converted from iron sucrose (IS) and treated with IIM according to product label and clinical routine...
January 10, 2019: BMC Nephrology
https://www.readbyqxmd.com/read/30630438/validation-of-diagnostic-utility-of-fasting-plasma-glucose-and-hba1c-in-stable-renal-transplant-recipients-one-year-after-transplantation
#12
Amin M Ussif, Anders Åsberg, Thea Anine Strøm Halden, Espen Nordheim, Anders Hartmann, Trond Jenssen
BACKGROUND: The use of HbA1c ≥6.5% for diagnosis of diabetes has been challenged for post-transplantation diabetes mellitus (PTDM) also known as new onset diabetes after transplantation (NODAT) due to a low sensitivity early after renal transplantation. PTDM diagnosed with an oral glucose tolerance test (OGTT) is highly predictable for long-term patient mortality. HbA1c was introduced for diagnosis based on the risk of developing diabetic retinopathy. The utility of HbA1c measures versus glucose criteria has not been widely assessed in stable transplant patients but still HbA1c is widely used in this population...
January 10, 2019: BMC Nephrology
https://www.readbyqxmd.com/read/30630437/low-use-of-routine-medical-care-among-african-americans-with-high-ckd-risk-the-jackson-heart-study
#13
Clarissa J Diamantidis, Clemontina A Davenport, Joseph Lunyera, Nrupen Bhavsar, Julia Scialla, Rasheeda Hall, Crystal Tyson, Mario Sims, Tara Strigo, Neil R Powe, L Ebony Boulware
BACKGROUND: Use of routine medical care (RMC) is advocated to address ethnic/racial disparities in chronic kidney disease (CKD) risks, but use is less frequent among African Americans. Factors associated with low RMC use among African Americans at risk of renal outcomes have not been well studied. METHODS: We examined sociodemographic, comorbidity, healthcare access, and psychosocial (discrimination, anger, stress, trust) factors associated with low RMC use in a cross-sectional study...
January 10, 2019: BMC Nephrology
https://www.readbyqxmd.com/read/30626362/long-term-incense-use-and-the-risk-of-end-stage-renal-disease-among-chinese-in-singapore-the-singapore-chinese-health-study
#14
Ting-Ting Geng, Tazeen Hasan Jafar, Jian-Min Yuan, Woon-Puay Koh
BACKGROUND: Experimental studies have shown that exposure to incense burning may have deleterious effects on kidney function and architecture. However, the association between chronic exposure to incense smoke and risk of end-stage renal disease (ESRD) has not been reported in epidemiologic studies. METHODS: We investigated this association in the Singapore Chinese Health Study, a prospective population-based cohort of 63,257 Chinese men and women of 45-74 years of age in Singapore during recruitment from 1993 to 1998...
January 9, 2019: BMC Nephrology
https://www.readbyqxmd.com/read/30626357/asian-americans-chronic-kidney-disease-in-a-nationally-representative-cohort
#15
Merle Kataoka-Yahiro, James Davis, Krupa Gandhi, Connie M Rhee, Victoria Page
BACKGROUND: There is a paucity of specific data on early stages of chronic kidney disease (CKD) among Asian Americans (AAs). The objective of this study was to examine the independent association of Asian race/ethnicity and socio-demographic and co-morbidity factors with markers of early kidney damage, ascertained by ACR levels, as well as kidney dysfunction, ascertained by eGFR levels in a large cross-sectional sample of AAs enrolled in the National Health and Nutrition Examination Survey (NHANES)...
January 9, 2019: BMC Nephrology
https://www.readbyqxmd.com/read/30626347/ihdip-a-controlled-randomized-trial-to-assess-the-security-and-effectiveness-of-the-incremental-hemodialysis-in-incident-patients
#16
Javier Deira, Miguel A Suárez, Francisca López, Emilio García-Cabrera, Antonio Gascón, Eduardo Torregrosa, Giannina E García, Jorge Huertas, Jose C de la Flor, Suleya Puello, Jonathan Gómez-Raja, Jesús Grande, José L Lerma, Carlos Corradino, Carlos Musso, Manuel Ramos, Jesús Martín, Carlo Basile, Francesco G Casino
BACKGROUND: Most people who make the transition to renal replacement therapy (RRT) are treated with a fixed dose thrice-weekly hemodialysis réegimen, without considering their residual kidney function (RKF). Recent papers inform us that incremental hemodialysis is associated with preservation of RKF, whenever compared with conventional hemodialysis. The objective of the present controlled randomized trial (RCT) is to determine if start HD with one sessions per week (1-Wk/HD), it is associated with better patient survival and other safety parameters...
January 9, 2019: BMC Nephrology
https://www.readbyqxmd.com/read/30621634/longitudinal-patterns-of-health-related-quality-of-life-and-dialysis-modality-a-national-cohort-study
#17
Nwamaka D Eneanya, Dugan W Maddux, Marta M Reviriego-Mendoza, John W Larkin, Len A Usvyat, Frank M van der Sande, Jeroen P Kooman, Franklin W Maddux
BACKGROUND: Health-related quality of life (HrQoL) varies among dialysis patients. However, little is known about the association of dialysis modality with HrQoL over time. We describe longitudinal patterns of HrQoL among chronic dialysis patients by treatment modality. METHODS: National retrospective cohort study of adult patients who initiated in-center dialysis or a home modality (peritoneal or home hemodialysis) between 1/2013 and 6/2015. Patients remained on the same modality for the first 120 days of the first two years...
January 8, 2019: BMC Nephrology
https://www.readbyqxmd.com/read/30621605/recurrence-of-goodpasture-syndrome-without-circulating-anti-glomerular-basement-membrane-antibodies-after-kidney-transplant-a-case-report
#18
V Thibaud, N Rioux-Leclercq, C Vigneau, S Morice
BACKGROUND: Goodpasture Syndrome (GS) is an autoimmune disease caused by the development of auto-antibodies against the Glomerular Basement Membrane (GBM). Linear deposit of immunoglobulins G on the GBM detected by immunofluorescence analysis of renal biopsies is a GS pathognomonic finding. GS is commonly monophasic and its incidence is 1.6 case per million per year. CASE PRESENTATION: This report describes and discusses the case of a 40-year-old woman who one year after allograft kidney transplant, presented with acute pulmonary and renal symptoms of GS, leading to acute graft dysfunction, without circulating anti-GBM antibody detection in laboratory assays...
January 8, 2019: BMC Nephrology
https://www.readbyqxmd.com/read/30616548/achievement-of-renal-anemia-kdigo-targets-by-two-different-clinical-strategies-a-european-hemodialysis-multicenter-analysis
#19
Maciej Drozdz, André Weigert, Fatima Silva, João Frazão, Abdulkareem Alsuwaida, Mahesh Krishnan, Werner Kleophas, Szymon Brzosko, Fredrik K Johansson, Stefan H Jacobson
BACKGROUND: The optimal treatment algorithm for iron therapy and the use of erythropoiesis-stimulating agents (ESA) in anemic hemodialysis (HD) patients has not been established. Hemoglobin (Hb) target levels can be achieved through more frequent intravenous (IV) iron use with lower ESA dose, or with less iron dosing but higher ESA. ESA therapy to correct anemia may result in severe arterial and venous thrombotic complications and the evidence base evaluating hard clinical outcomes related to the use of IV iron is sparse...
January 7, 2019: BMC Nephrology
https://www.readbyqxmd.com/read/30606155/successful-re-administration-of-pazopanib-in-a-patient-with-metastatic-renal-cell-carcinoma-and-a-history-of-pazopanib-induced-nephrotic-syndrome-a-case-report
#20
So-Yeon Jeon, Na-Ri Lee, Chang-Yeol Yim
BACKGROUND: Drug-induced nephrotic syndrome (NS) can be resolved by eliminating the causative agents. However, patients with metastatic cancer have not been previously reported to achieve complete recovery from anticancer drug-induced NS after discontinuation of treatment, because many patients die of cancer progression before NS is restored. CASE PRESENTATION: A 67-year-old man presented with edema of both lower extremities. He received pazopanib therapy for recurrent metastatic renal cell carcinoma (mRCC) for 17 months...
January 3, 2019: BMC Nephrology
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