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BMC Nephrology

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https://www.readbyqxmd.com/read/27899079/vasopressin-related-copeptin-is-a-novel-predictor-of-early-endothelial-dysfunction-in-patients-with-adult-polycystic-kidney-disease
#1
Ismail Kocyigit, Mahmut Ilker Yilmaz, Ozkan Gungor, Eray Eroglu, Aydin Unal, Ozcan Orscelik, Bulent Tokgoz, Murat Sipahioglu, Ahmet Sen, Juan Jesús Carrero, Oktay Oymak, Jonas Axelsson
BACKGROUND: In this study, we examined the relative usefulness of serum copeptin levels as a surrogate marker of vasopressin (AVP) in adult polycystic kidney disease (ADPKD) by correlating it with baseline and longitudinal changes in markers of both renal function and common CVD manifestations (hypertensive vascular disease, atherosclerosis and endothelial dysfunction) that accompany the progression of this disease. METHODS: We studied a cohort of young and otherwise healthy ADPKD patients (n = 235) and measured cardiovascular function using flow-mediation dilatation (FMD), carotid intima media thickness (cIMT) and pulse wave velocity (PWV), as well as serum copeptin (commercial ELISA, a stable marker of AVP activity)...
November 30, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27887592/association-of-peripheral-arterial-disease-with-all-cause-and-cardiovascular-mortality-in-hemodialysis-patients-a-meta-analysis
#2
Yi Yang, Yong Ning, Weifeng Shang, Ran Luo, Lixi Li, Shuiming Guo, Gang Xu, Xiaofeng He, Shuwang Ge
BACKGROUND: Recent studies have shown an association between peripheral arterial disease (PAD) and increased risk of mortality in hemodialysis (HD) patients; however, the estimates vary widely and are inconsistent. It is necessary to elucidate the degree of mortality risk for PAD patients in HD population. METHODS: PubMed, EMBASE, Web of Science and Cochrane Library (from inception to September 4th, 2016) were systematically searched for cohort studies assessing the association between PAD and mortality in HD patients...
November 25, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27884120/removal-of-free-light-chains-in-hemodialysis-patients-without-multiple-myeloma-a-crossover-comparison-of-three-different-dialyzers
#3
Gabriele Donati, Maria Ilaria Moretti, Olga Baraldi, Alessandra Spazzoli, Irene Capelli, Giorgia Comai, Antonio Marchetti, Maria Sarma, Rita Mancini, Gaetano La Manna
BACKGROUND: Immunoglobulin light chains are classified as middle molecule uremic toxins able to interact with B lymphocyte membranes leading to the activation of transmembrane signaling. The ensuing impairment of neutrophil function can contribute to the chronic inflammation state of uremic patients, and the increased risk of bacterial infections or vascular calcifications. The aim of this crossover observational study was to assess the difference in free light chain removal by three different hemodialysis filters in patients not affected by multiple myeloma...
November 25, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27884116/kidney-disease-in-the-elderly-biopsy-based-data-from-14-renal-centers-in-poland
#4
Agnieszka Perkowska-Ptasinska, Dominika Deborska-Materkowska, Artur Bartczak, Tomasz Stompor, Tomasz Liberek, Barbara Bullo-Piontecka, Anna Wasinska, Agnieszka Serwacka, Marian Klinger, Jolanta Chyl, Michal Kuriga, Robert Malecki, Krzysztof Marczewski, Bogdan Hryniewicz, Tadeusz Gregorczyk, Monika Wieliczko, Stanislaw Niemczyk, Olga Rostkowska, Leszek Paczek, Magdalena Durlik
BACKGROUND: Longer life expectancy is associated with an increasing prevalence of kidney disease. Aging itself may cause renal damage, but the spectrum of kidney disorders that affect elderly patients is diverse. Few studies, mostly form US, Asia and West Europe found differences in the prevalence of some types of kidney diseases between elderly and younger patients based on renal biopsy findings, with varied proportion between glomerulopathies and arterionephrosclerosis as a dominant injury found...
November 25, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27881101/knowledge-barriers-and-facilitators-of-exercise-in-dialysis-patients-a-qualitative-study-of-patients-staff-and-nephrologists
#5
Manisha Jhamb, Mary L McNulty, Gerald Ingalsbe, Julie W Childers, Jane Schell, Molly B Conroy, Daniel E Forman, Andrea Hergenroeder, Mary Amanda Dew
BACKGROUND: Despite growing evidence on benefits of increased physical activity in hemodialysis (HD) patients and safety of intra-dialytic exercise, it is not part of standard clinical care, resulting in a missed opportunity to improve clinical outcomes in these patients. To develop a successful exercise program for HD patients, it is critical to understand patients', staff and nephrologists' knowledge, barriers, motivators and preferences for patient exercise. METHODS: In-depth interviews were conducted with a purposive sample of HD patients, staff and nephrologists from 4 dialysis units...
November 24, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27881100/high-prevalence-of-non-steroidal-anti-inflammatory-drug-use-among-acute-kidney-injury-survivors-in-the-southern-community-cohort-study
#6
Loren Lipworth, Khaled Abdel-Kader, Jennifer Morse, Thomas G Stewart, Edmond K Kabagambe, Sharidan K Parr, Kelly A Birdwell, Michael E Matheny, Adriana M Hung, William J Blot, T Alp Ikizler, Edward D Siew
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used and have been linked to acute kidney injury (AKI), chronic kidney disease (CKD) and cardiovascular disease (CVD). Patients who survive an AKI episode are at risk for future adverse kidney and cardiovascular outcomes. The objective of our study was to examine the prevalence and predictors of NSAID use among AKI survivors. METHODS: The Southern Community Cohort Study is a prospective study of low-income adults aged 40-79 in the southeastern US...
November 24, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27881094/neutrophil-lymphocyte-ratio-is-associated-with-arterial-stiffness-in-patients-with-peritoneal-dialysis
#7
Kedan Cai, Qun Luo, Beixia Zhu, Lina Han, Dan Wu, Zhiwei Dai, Kaiyue Wang
BACKGROUND: Patients with peritoneal dialysis are in the persistent inflammation state and have elevated arterial stiffness. Neutrophil-lymphocyte ratio(NLR) is a new inflammatory marker in renal and cardiac disorders. Brachial-ankle pulse wave velocity (baPWV) is a non-invasive measurement, which is widely used as a surrogate marker of arterial stiffness. However, there is little evidence to show an association between NLR and baPWV in patients with peritoneal dialysis. The aim of this cross-section study was to investigate the relationship between NLR and arterial stiffness measured by baPWV in patients with peritoneal dialysis...
November 24, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27881093/continuous-quality-improvement-in-nephrology-a-systematic-review
#8
Julie Wright Nunes, F Jacob Seagull, Panduranga Rao, Jonathan H Segal, Nandita S Mani, Michael Heung
BACKGROUND: Continuous quality improvement (CQI) has been successfully applied in business and engineering for over 60 years. While using CQI techniques within nephrology has received increased attention, little is known about where, and with what measure of success, CQI can be attributed to improving outcomes within nephrology care. This is particularly important as payors' focus on value-based healthcare and reimbursement is tied to achieving quality improvement thresholds. We conducted a systematic review of CQI applications in nephrology...
November 24, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27876011/nivolumab-associated-acute-glomerulonephritis-a-case-report-and-literature-review
#9
Kyungsuk Jung, Xu Zeng, Marijo Bilusic
BACKGROUND: Immune checkpoint inhibitors are changing the landscape of oncology treatment as they are significantly improving treatment for multiple malignancies. Nivolumab, an anti-programmed death 1 antibody, is a US Food and Drug Administration-approved treatment for melanoma, non-small cell lung cancer, and kidney cancer but can result in a spectrum of autoimmune side effects. Adverse effects can occur within any organ system in the body including the colon, lung, liver, endocrine systems, or kidneys...
November 22, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27876008/physical-activity-and-metabolic-health-in-chronic-kidney-disease-a-cross-sectional-study
#10
Wilson Bowlby, Leila R Zelnick, Connor Henry, Jonathan Himmelfarb, Steven E Kahn, Bryan Kestenbaum, Cassianne Robinson-Cohen, Kristina M Utzschneider, Ian H de Boer
BACKGROUND: Patients with chronic kidney disease (CKD) are at high risk of progression to end stage renal disease and cardiovascular events. Physical activity may reduce these risks by improving metabolic health. We tested associations of physical activity with central components of metabolic health among people with moderate-severe non-diabetic CKD. METHODS: We performed a cross-sectional study of 47 people with CKD (estimated GFR <60 ml/min/1.73 m(2)) and 29 healthy control subjects...
November 22, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27876003/pla2r-antibodies-and-pla2r-glomerular-deposits-in-psoriasis-patients-with-membranous-nephropathy
#11
Yong-Chun Ge, Bo Jin, Cai-Hong Zeng, Ming-Chao Zhang, Da-Cheng Chen, Ru Yin, Wei-Bo Le
BACKGROUND: The association between psoriasis and membranous nephropathy (MN) remains largely unclear. We examined the prevalence of serum PLA2R antibody and characterized the expression of PLA2R and THSD7A in glomeruli in patients with MN and psoriasis. METHODS: A total of 24 patients with MN without evidence of a secondary cause except psoriasis were enrolled. The clinical and pathological features were retrospectively analyzed. Serum anti-PLA2R antibody was measured using IFA Mosaic...
November 22, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27875991/the-prevalence-of-renal-impairment-in-individuals-seeking-hiv-testing-in-urban-malawi
#12
Nicola Glaser, Sam Phiri, Tom Bruckner, Dominic Nsona, Hannock Tweya, Nomeda Ahrenshop, Florian Neuhann
BACKGROUND: Chronic kidney disease (CKD) poses a major health threat to people living in low- and middle-income countries, especially when it is combined with HIV, antiretroviral treatment (ART) or communicable and non-communicable diseases. Data about the prevalence of CKD and its association with other diseases is scarce, particularly in HIV-negative individuals. This study estimated the prevalence of CKD in individuals who were either HIV-positive (and ART-naïve) or HIV-negative in an urban Malawian population...
November 22, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27871261/quantitative-characterization-of-t-cell-repertoire-and-biomarkers-in-kidney-transplant-rejection
#13
Houda Alachkar, Martin Mutonga, Taigo Kato, Sowjanya Kalluri, Yoichi Kakuta, Motohide Uemura, Ryoichi Imamura, Norio Nonomura, Vikas Vujjini, Sami Alasfar, Hamid Rabb, Yusuke Nakamura, Nada Alachkar
BACKGROUND: T-cell-mediated rejection (TCMR) remains a major cause of kidney allograft failure. The characterization of T-cell repertoire in different immunological disorders has emerged recently as a novel tool with significant implications. We herein sought to characterize T-cell repertoire using next generation sequencing to diagnose TCMR. METHODS: In this prospective study, we analyzed samples from 50 kidney transplant recipients. We collected blood and kidney transplant biopsy samples at sequential time points before and post transplant...
November 21, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27871254/familial-aggregation-of-albuminuria-and-arterial-hypertension-in-an-aboriginal-australian-community-and-the-contribution-of-variants-in-ace-and-tp53
#14
David L Duffy, Stephen P McDonald, Beverley Hayhurst, Sianna Panagiotopoulos, Trudy J Smith, Xing L Wang, David E Wilcken, Natalia L Duarte, John Mathews, Wendy E Hoy
BACKGROUND: Aboriginal Australians are at high risk of cardiovascular, metabolic and renal diseases, resulting in a marked reduction in life expectancy when compared to the rest of the Australian population. This is partly due to recognized environmental and lifestyle risk factors, but a contribution of genetic susceptibility is also likely. METHODS: Using results from a comprehensive survey of one community (N = 1350 examined individuals), we have tested for familial aggregation of plasma glucose, arterial blood pressure, albuminuria (measured as urinary albumin to creatinine ratio, UACR) and estimated glomerular filtration rate (eGFR), and quantified the contribution of variation at four candidate genes (ACE; TP53; ENOS3; MTHFR)...
November 21, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27871253/impact-of-residual-urine-volume-decline-on-the-survival-of-chronic-hemodialysis-patients-in-kinshasa
#15
Vieux Momeme Mokoli, Ernest Kiswaya Sumaili, François Bompeka Lepira, Jean Robert Rissassy Makulo, Justine Busanga Bukabau, Patrick Parmba Osa Izeidi, Jeannine Losa Luse, Stéphane Kalambay Mukendi, Désiré Kulimba Mashinda, Nazaire Mangani Nseka
BACKGROUND: Despite the multiple benefits of maintaining residual urine volume (RUV) in hemodialysis (HD), there is limited data from Sub-Saharan Africa. The aim of this study was to assess the impact of RUV decline on the survival of HD patients. METHODS: In a retrospective cohort study, 250 consecutive chronic HD patients (mean age 52.5 years; 68.8% male, median HD duration 6 months) from two hospitals in the city of Kinshasa were studied, between January 2007 and July 2013...
November 21, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27871238/long-chain-n-3-polyunsaturated-fatty-acids-and-vascular-function-in-patients-with-chronic-kidney-disease-and-healthy-subjects-a-cross-sectional-and-comparative-study
#16
Morten Borg, My Svensson, Johan V Povlsen, Erik B Schmidt, Christian Aalkjær, Jeppe H Christensen, Per Ivarsen
BACKGROUND: Patients with chronic kidney disease have a markedly increased cardiovascular mortality compared with the general population. Long chain n-3 polyunsaturated fatty acids have been suggested to possess cardioprotective properties. This cross-sectional and comparative study evaluated correlations between hemodynamic measurements, resistance artery function and fish consumption to the content of long chain n-3 polyunsaturated fatty acids in adipose tissue, a long-term marker of seafood intake...
November 21, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27863475/spanish-modified-version-of-the-palliative-care-outcome-scale-symptoms-renal-cross-cultural-adaptation-and-validation
#17
Daniel Gutiérrez-Sánchez, Juan P Leiva-Santos, Rosa Sánchez-Hernández, Domingo Hernández-Marrero, Antonio I Cuesta-Vargas
BACKGROUND: Patients with chronic kidney disease (CKD) have a high symptoms burden that is related to a poor health-related quality of life (HRQoL) and high costs of care. Validated instruments may be useful for assessing the symptoms and monitoring outcomes in these patients. The Palliative care Outcome Scale-Symptoms Renal (POS-S Renal) is a patient-reported outcome measure for assessing symptoms in CKD stage 4-5. This study is the first cross-cultural adaptation and psychometric analysis of this clinical tool...
November 18, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27855647/albuminuria-serum-antioxidant-enzyme-levels-and-markers-of-hemolysis-and-inflammation-in-steady-state-children-with-sickle-cell-anemia
#18
Karen E Itokua, Jean Robert Makulo, François B Lepira, Michel N Aloni, Pépé M Ekulu, Ernest K Sumaili, Justine B Bukabau, Vieux M Mokoli, Augustin L Longo, François M Kajingulu, Chantal V Zinga, Yannick M Nlandu, Yannick M Engole, Pierre Z Akilimali, René M Ngiyulu, Jean Lambert Gini, Nazaire M Nseka
BACKGROUND: Oxidative stress is thought to be involved in the pathogenesis of microalbuminuria in Sickle cell anemia (SCA). Antioxidant enzymes such as glutathione peroxidase (GPx) and Cu-Zn superoxide dismutase (SOD) may play an important protective role. This study aimed to evaluate the association between albuminuria and these two antioxidant enzymes. METHODS: We consecutively recruited Steady state children aged between 2 and 18 years old with established diagnosis of homozygous SCA in two hospitals of Kinshasa/DR Congo...
November 17, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27855638/alteration-of-histone-h3k4-methylation-in-glomerular-podocytes-associated-with-proteinuria-in-patients-with-membranous-nephropathy
#19
Takayuki Fujino, Naoyuki Hasebe
BACKGROUND: Histone H3K4 trimethylation (H3K4 me3) is found in active euchromatic regions and plays an important role in podocyte function in which actin filaments are abundant in the foot processes. The pathogenesis of membranous nephropathy (MN), the most prevalent cause of primary nephrotic syndrome in the middle-aged and elderly, is podocyte dysfunction. METHODS: We investigated the role of H3K4 me3 in podocyte dysfunction in nephrotic syndrome using cultured podocytes and a mouse proteinuria model induced by LPS...
November 17, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27852236/effects-of-intravenous-iron-on-fibroblast-growth-factor-23-fgf23-in-haemodialysis-patients-a-randomized-controlled-trial
#20
Matthew A Roberts, Louis Huang, Darren Lee, Robert MacGinley, Stefanie M A Troster, Annette B Kent, Sukhvinder S Bansal, Iain C Macdougall, Lawrence P McMahon
BACKGROUND: Intravenous iron affects serum levels of intact fibroblast growth factor-23 (iFGF23) and its cleavage product c-terminal FGF23 (cFGF23) in iron-deficient people with normal renal function. We hypothesized that intravenous iron modulates iFGF23 and cFGF23 in haemodialysis patients differently according to the type of iron used. METHODS: Prevalent, stable haemodialysis patients requiring protocol-based intravenous iron therapy were randomized to a single 200 mg dose of either ferric carboxymaltose (FCM) or iron sucrose (IS)...
November 16, 2016: BMC Nephrology
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