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British Journal of Dermatology

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https://www.readbyqxmd.com/read/29150858/q-switched-532nm-laser-energy-causes-significant-vascular-damage-in-the-capillary-plexus-how-does-this-affect-laser-tattoo-removal
#1
LETTER
M Murphy
Tattoos can be effectively removed using Q-switched and picosecond lasers at four wavelengths - 1064, 755, 694 and 532nm(1,2,3,4) . However, there are two particular problems with the 532nm line. Firstly, it is well absorbed by the melanin in the epidermis, due to its relatively high absorption coefficient(5) , (μa_mel = 56 cm(-1) for typical Caucasian skin). Secondly, 532nm is also strongly absorbed in the haemoglobin located in the capillary plexus(5) (μa_HbO = 260 cm(-1) ). This article is protected by copyright...
November 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29150847/chronic-sun-exposure-is-associated-with-distinct-histone-acetylation-changes-in-human-skin
#2
S Ding, J Chen, Q Zeng, J Lu, L Tan, A Guo, J Kang, S Yang, Y Xiang, C Zuo, J Huang
BACKGROUND: Photoaging is attributed to continuous sunlight or artificial UV exposure and manifests the clinical and histological changes of skin. Epigenetic changes have been found to be involved in the pathogenesis of photoaging. However, the underlying mechanisms are unclear. OBJECTIVES: To analyse histone modification patterns in sun-exposed and non-exposed skins, and identify the abnormally histone modified-genes related to photoaging. METHODS: Skin biopsies were collected both from the outer forearm (sun-exposed area) and the buttock (sun-protected area) in 20 healthy middle-aged female volunteers...
November 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29150844/a-phase-i-randomised-controlled-trial-to-evaluate-safety-and-clinical-effect-of-topically-applied-gsk2981278-ointment-in-a-psoriasis-plaque-test
#3
LETTER
E G Kang, S Wu, A Gupta, Y-L von Mackensen, H Siemetzki, J M Freudenberg, W Wigger-Alberti, Y Yamaguchi
RORγt, a truncated isoform of retinoic acid receptor-related orphan receptor gamma (RORγ), is a transcription factor involved in Th17 cell differentiation. It is expressed in a few distinct types of immune cells and described as the master regulator of Th17 cytokine expression(1) . RORγ has identical ligand-binding domains as RORγt(2) ; consequently, compounds targeting RORγ are also expected to modulate Th17 cell activity. This article is protected by copyright. All rights reserved.
November 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29150843/liver-fibrosis-is-associated-with-cutaneous-inflammation-in-the-imiquimod-induced-murine-model-of-psoriasiform-dermatitis
#4
P Vasseur, M Pohin, J F Jégou, L Favot, N Venisse, J Mcheik, F Morel, J C Lecron, C Silvain
BACKGROUND: Psoriasis associates several extra-cutaneous manifestations. Little is known about hepatic parameters specifically associated with psoriasis. OBJECTIVE: To study whether psoriasiform dermatitis is associated with liver injury. METHODS: We studied liver parameters of inflammation and fibrosis in a murine model of psoriasiform dermatitis induced by topical application of imiquimod for nine weeks. RESULTS: Topical treatment with imiquimod induced a form of psoriasiform dermatitis reminiscent of the human disorder, characterized by thickened and scaly skin, psoriasiform epidermal hyperplasia, altered keratinocyte differentiation, and cutaneous overexpression of interleukin-17A...
November 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29150841/how-well-are-reporting-guidelines-and-trial-registration-used-by-dermatology-journals-to-limit-bias-a-meta-epidemiological-study
#5
LETTER
C Cook, J X Checketts, P Atakpo, N Nelson, M Vassar
Reporting guidelines were created to ensure research is reported in a transparent, complete manner that minimizes reporting bias. Further, these guidelines assist editors and peer reviewers when reviewing manuscripts for publication and readers when critically appraising published articles (1) . Though reporting guidelines and trial registration have been associated with improved reporting quality, the full effect of these guidelines has yet to manifest because many journals do not require their use (2) . This article is protected by copyright...
November 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29150837/aprepitant-improves-refractory-pruritus-in-primary-cutaneous-t-cell-lymphomas-experience-of-the-spanish-working-group-on-cutaneous-lymphomas
#6
LETTER
L Maroñas-Jiménez, T Estrach, F Gallardo, A Pérez, H Andrés Borja, O Servitje, S Pérez Gala, M Linares Barrio, D Jiménez Gallo, D J Sanz-Bueno, D Lora, V Monsálvez, P L Ortiz-Romero
Aprepitant has shown a promising anti-itch activity in several cases of cutaneous T-cell lymphomas (CTCLs)(1-8) . We sought to determine its antipruritic efficacy in a large multicenter series of CTCLs patients with refractory pruritus and, secondarily, to define possible clinical predictors of response.A retrospective, analytical review of the Spanish Working Group on Cutaneous Lymphoma database was designed to collect patients with CTCLs and refractory pruritus, treated with aprepitant from 2009 to 2013. This article is protected by copyright...
November 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29150836/serum-thymus-and-activation-regulated-chemokine-tarc-is-associated-with-the-severity-of-drug-reaction-with-eosinophilia-and-systemic-symptoms-drug-induced-hypersensitivity-syndrome-dress-dihs
#7
LETTER
Y Nakamura-Nishimura, F Miyagawa, K Miyashita, R Ommori, H Azukizawa, H Asada
Drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome (DRESS/DIHS) is a severe adverse drug-induced reaction with reactivation of human herpesvirus 6 (HHV-6).(1-3) We previously reported that serum thymus and activation-regulated chemokine (TARC) levels were markedly increased in patients with DIHS and suggested TARC as a useful diagnostic marker of DIHS in the early stage.(4,5) In this study, we determined whether serum TARC levels correlate with the severity of clinical symptoms and laboratory data in patients with DRESS/DIHS...
November 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29150835/the-expanding-spectrum-of-clinical-phenotypes-associated-with-pstpip1-mutations-from-papa-to-pami-syndrome-and-beyond
#8
LETTER
H-W Klötgen, H Beltraminelli, N Yawalkar, M E van Gijn, D Holzinger, L Borradori
Mutations in the PSTPIP1 gene encoding proline-serine-threonine-phosphatase interactive protein 1 were first identified in an autosomal dominant syndrome called PAPA associated with pyogenic sterile arthritis, pyoderma gangrenosum (PG) and cystic acne.(1,2) . We report a patient with an autoinflammatory syndrome called PSTPIP1-associated myeloid-related proteinemia inflammatory (PAMI) syndrome.(3) A 23-year-old man had a 3-year-history of skin ulcerations. This article is protected by copyright. All rights reserved...
November 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29150833/response-to-il-36-in-hidradenitis-suppurativa-evidence-for-a-distinctive-pro-inflammatory-role-and-a-key-factor-in-the-development-of-an-inflammatory-loop
#9
LETTER
A Balato, G Caiazzo, R Di Caprio, S Lembo, A Raimondo, G Monfrecola, G Fabbrocini
we read with interest the recent paper of Hessam et al.(1) regarding the involvement of IL-36 in hidradenitis suppurativa (HS). They have showed that agonist members of IL-36 were significantly overexpressed in HS lesional skin. This article is protected by copyright. All rights reserved.
November 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29150832/response-to-clinical-presentation-of-terbinafine-induced-severe-liver-injury-and-the-value-of-laboratory-monitoring-a-critically-appraised-topic
#10
LETTER
A Khurana, K Sardana, V Bhardwaj
We read with interest the article by Kramer et al entitled "Clinical presentation of terbinafine-induced severe liver injury and the value of laboratory monitoring: a critically appraised topic". (1) We would like to bring to focus our experience in this regard. With increasing concerns of reduced susceptibility to terbinafine(2) and an upsurge of recalcitrant cutaneous dermatophytoses, dermatologists in India have been using higher doses of terbinafine for cutaneous dermatophytoses, as used in the early literature with this drug (upto 500mg/day in single or divided doses) (3) ; and for longer periods of time...
November 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29143981/high-plasma-25-hydroxyvitamin-d-and-high-risk-of-non-melanoma-skin-cancer-a-mendelian-randomisation-study-of-97849-individuals
#11
U C Winsløw, B G Nordestgaard, S Afzal
BACKGROUND: High plasma 25-hydroxyvitamin D (25 (OH)D) concentration has been associated observationally with high risk of non-melanoma skin cancer, while many studies suggest that vitamin D could have a protective effect on cancer. The true association between vitamin D and risk of skin cancer remains unclear. OBJECTIVES: In this Mendelian randomisation study we tested the hypothesis that genetically high plasma 25(OH)D protects against non-melanoma skin cancer...
November 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29143979/analysis-of-anti-tnf-induced-skin-lesions-reveals-strong-th1-activation-with-some-distinct-immunological-characteristics
#12
E Stoffel, H Maier, E Riedl, M-C Brüggen, B Reininger, M Schaschinger, C Bangert, E Guenova, G Stingl, P M Brunner
BACKGROUND: Psoriasiform and eczematous eruptions are the most common dermatological adverse reaction linked to anti-TNF-α therapy. Yet, a detailed characterization of their immune phenotype is lacking. OBJECTIVES: We sought to characterize anti-TNF-α induced inflammatory skin lesions on a histopathologic, cellular and molecular level, compared to psoriasis, eczema (atopic dermatitis), and healthy control skin. METHODS: Histopathologic evaluation, gene expression (quantitative RT-PCR) and computer-assisted immunohistologic studies (TissueFAXS) were performed on 19 skin biopsies from IBD (n=17) and rheumatoid arthritis (n=2) patients with new-onset inflammatory skin lesions during anti-TNF-α-therapy...
November 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29131317/molecular-photoprotection-of-human-keratinocytes-in-vitro-by-the-naturally-occurring-mycosporine-like-amino-acid-maa-palythine
#13
K P Lawrence, R Gacesa, P F Long, A R Young
BACKGROUND: Solar ultraviolet radiation (UVR) induces molecular and genetic changes in the skin, which result in skin cancer, photoageing and photosensitivity disorders. The use of sunscreens is advocated to prevent such photodamage, however most formulations contain synthetic UVR filters that are non-biodegradable and can damage fragile marine ecosystems. Mycosporine-like amino acids (MAA) are natural UVR-absorbing compounds that have evolved in marine species for protection against chronic UVR exposure in shallow-water habitats...
November 13, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29124728/generating-new-evidence-improving-clinical-practice-and-developing-research-capacity-the-benefits-of-recruiting-to-the-u-k-dermatology-clinical-trials-network-s-stop-gap-and-blister-trials
#14
J M Batchelor, A Chapman, F E Craig, K E Harman, G Kirtschig, A Martin-Clavijo, A D Ormerod, S Walton, H C Williams
Clinical trials may benefit clinical practice in three ways: firstly, clinicians may change their practice according to the new trial evidence; secondly, clinical processes can improve when working on a trial; and thirdly, research capacity is increased. We held a meeting to present and discuss the results of two large multicentre randomized controlled trials delivered through the U.K. Dermatology Clinical Trials Network. Investigators gave reflections on how the trials had changed their clinical practice. The STOP GAP trial showed that prednisolone and ciclosporin are equally effective as first-line systemic treatment for pyoderma gangrenosum...
November 10, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29124750/response-to-providing-dermatological-care-in-resource-limited-settings-barriers-and-potential-solutions-reply-from-authors
#15
LETTER
A Y Chang, S K Kiprono, T A Maurer
We thank Drs. Mahé and Faye for their interest in our article. We applaud them for their tremendous work in improving the delivery of dermatologic care through their programme with healthcare professionals in Mali. This article is protected by copyright. All rights reserved.
November 9, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29124739/psychological-stress-and-psoriasis-a-systematic-review-and-meta-analysis
#16
REVIEW
I Snast, O Reiter, L Atzmony, Y A Leshem, E Hodak, D Mimouni, L Pavlovsky
BACKGROUND: Psychological stress has long been linked with psoriasis exacerbation/onset. However, it is unclear if they are associated. OBJECTIVE: To determine if antecedent psychological stress and psoriasis exacerbation/onset are associated. METHODS: A comprehensive search of Pubmed, PsycINFO, Cochrane library, and clinicaltrials. gov databases was performed. Studies investigating the association between preceding psychological stress and psoriasis exacerbation/onset were classified as cross-sectional, case-control or cohort...
November 9, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29124736/response-to-providing-dermatological-care-in-resource-limited-settings-barriers-and-potential-solutions
#17
LETTER
A Mahé, O Faye
We read with interest the paper from Chang et al (1). However, the authors overlooked certain solutions that were developed by our team to improve on a large scale the problem of skin diseases (SD) in resource limited settings (RLS), through an organized, public health approach (2-4). This article is protected by copyright. All rights reserved.
November 9, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29114862/fumaric-acid-esters-in-combination-with-a-6-week-course-of-narrow-band-uvb-provides-for-an-accelerated-response-as-compared-to-fumaric-acid-esters-monotherapy-in-patients-with-moderate-to-severe-plaque-psoriasis-a-randomized-prospective-clinical-study
#18
S Tzaneva, A Geroldinger, H Trattner, A Tanew
BACKGROUND: Fumaric acid esters are (FAE) safe and effective in patients with moderate to severe psoriasis but have a slow onset of action. A short-term combination with narrow-band UVB (NB UVB) may substantially accelerate the therapeutic response in the induction phase of treatment. OBJECTIVES: To assess the synergistic effect of a 6-week course of NB UVB phototherapy in addition to fumaric acid esters in adult patients with moderate to severe plaque psoriasis...
November 8, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29106713/a-systematic-review-of-diagnostic-criteria-for-psoriasis-in-adults-and-children-evidence-from-studies-with-a-primary-aim-to-develop-or-validate-diagnostic-criteria
#19
REVIEW
E Burden-Teh, R C Phillips, K S Thomas, S Ratib, D Grindlay, R Murphy
BACKGROUND: The diagnosis of psoriasis in adults and children is made clinically, for both patient management and the selection of participants in research. Diagnostic criteria provide a structure for clinical assessment, which in turn helps standardise patient recruitment into clinical trials and case definitions in observational studies. OBJECTIVE: The aim of this systematic review was to identify and critically appraise the published studies to date that had a primary research aim to develop or validate diagnostic criteria for psoriasis...
November 6, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29106703/prevalence-and-incidence-of-chronic-spontaneous-urticaria-in-the-entire-korean-adult-population
#20
LETTER
Y S Kim, S H Park, K Han, C H Bang, J H Lee, Y M Park
Ethnic differences and temporal trends in the epidemiology of chronic spontaneous urticaria (CSU) are not well understood, especially in East Asia.(1-3) The aim of our study was to investigate trends in the prevalence and incidence of CSU among adult Korean subjects from 2006 to 2014 using a nationwide, population-based study. This article is protected by copyright. All rights reserved.
November 6, 2017: British Journal of Dermatology
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