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British Journal of Dermatology

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https://www.readbyqxmd.com/read/28722209/reporting-of-outcomes-in-randomised-controlled-trials-on-nail-psoriasis-a-systematic-review
#1
REVIEW
C I M Busard, J Y C Nolte, M C Pasch, Ph I Spuls
Harmonization of outcome measures is needed to increase the value of clinical trials on nail psoriasis. To provide the first step in core outcome set (COS) development, a systematic review was conducted to identify outcome domains and instruments reported in (ongoing) randomised controlled trials (RCTs) on nail psoriasis. Identified outcome domains included clinical signs, quality of life, symptoms and delivery of care. A NAPSI was most commonly used to assess clinical signs (73.8% of studies). Other outcome instruments used included the NAS, composite fingernail score, a physician global assessment, individual nail features or a combination of these...
July 19, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28722163/risk-of-cancer-in-patients-with-psoriasis-on-biologic-therapies-a-systematic-review
#2
REVIEW
E Peleva, L S Exton, K Kelley, K J Mason, C H Smith
Biologic therapies are highly effective in psoriasis, but have profound effects on innate and adaptive immune pathways that may negatively impact on cancer immunosurveillance mechanisms. To investigate the risk of cancer in psoriasis patients treated with biologic therapy we searched Medline, Embase, and the Cochrane Library (up to August 2016) for randomized control trials, prospective cohort studies and systematic reviews that reported cancer incidence in people exposed to biologic therapy for psoriasis compared to a control population...
July 19, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28722136/changes-in-il-17a-macrophage-derived-chemokine-and-adiponectin-following-treatment-of-psoriasis-with-calcipotriol-plus-betamethasone-dipropionate-aerosol-foam-results-from-the-pso-able-study
#3
LETTER
M Røpke, C Bulai Livideanu, R Kaldate, A Snel, C Paul
Psoriasis vulgaris is an immune-mediated disease characterized by skin and systemic inflammation that is associated with an increased risk of comorbidities such as cardiovascular disease. Although typically associated with moderate-to-severe psoriasis, recent data suggests that increased vascular inflammation may occur in patients with milder psoriasis. It has been shown that systemic treatment of psoriasis leads to an improvement in cardiovascular-associated biomarkers, eg adiponectin levels. This article is protected by copyright...
July 19, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28722122/wet-work-exposure-and-hand-eczema-among-healthcare-workers-a-cross-sectional-study
#4
N Hamnerius, C Svedman, O Bergendorff, J Björk, M Bruze, A Pontén
BACKGROUND: Hand eczema is more common in healthcare workers compared to the general population. The hands are subject to changing occupational exposures due to mandatory hygiene regulations for health care workers. OBJECTIVES: To describe the exposure due to hygiene procedures and investigate the associations between occupational hand washing, use of non-sterile gloves, and hand disinfectant and self-reported hand eczema. METHODS: Cross-sectional study with an electronic questionnaire distributed to 28 762 hospital employees in southern Sweden...
July 19, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28718937/wound-healing-in-epidermolysis-bullosa
#5
L B Tuderman, J E Mellerio
Epidermolysis bullosa (EB) is a group of inherited diseases characterised by recurrent skin blistering due to impaired epidermal or dermo-epidermal adhesion. In some subtypes, damage to internal organs causes serious comorbidities, and an increased risk of early and aggressive squamous cell carcinoma (SCC) characterizes recessive dystrophic EB (RDEB). It is likely that EB will only be cured by mutation-correction interventions, but until that goal becomes a reality we need to pool and extend knowledge about wound management and other strategies to improve quality of life for people with EB...
July 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28718933/treatment-of-hidradenitis-suppurativa-with-rifampicin-have-we-forgotten-tuberculosis
#6
P Mendes-Bastos, R Macedo, R Duarte
Hidradenitis suppurativa (HS) is a chronic, recurrent and debilitating skin disease of the hair follicle that is accompanied by systemic inflammation. Treating HS is challenging, and therapeutic tools as diverse as topical and systemic antibiotics, biologics, intralesional steroids, surgical procedures or light and laser therapies are frequently needed. The combination of oral clindamycin and rifampicin (R+C) has been suggested as a possible treatment regimen (level of evidence III, strength of recommendation C)...
July 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28718898/exposure-to-biologic-therapies-during-conception-and-pregnancy-a-systematic-review
#7
E M Pottinger, R T Woolf, L S Exton, A D Burden, C Nelson-Piercy, C H Smith
Biologic therapies are effective treatments for psoriasis and are often used in women of childbearing age. To evaluate the safety of biologic therapy in conception and/or pregnancy, we have performed a systematic review of Pubmed, MEDLINE, EMBASE and Cochrane databases for multivariable adjusted studies of women exposed to biologic therapy relevant to the treatment of psoriasis during conception and/or pregnancy. We identified four population-based cohort studies involving 1300 women exposed to TNF-α inhibitors (TNFi) 3 months prior to or during the first 3 months of pregnancy...
July 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28718895/considering-the-impact-of-pregnancy-on-the-natural-history-of-hidradenitis-suppurativa
#8
P Perng, J G Zampella, G A Okoye
Hidradenitis suppurativa (HS) is a chronic and debilitating inflammatory skin disease that disproportionately affects women of childbearing age. Yet, little has been written about the impact of pregnancy on the natural history of HS. It has been postulated that apocrine-gland activity diminishes in pregnancy, accounting for symptom remission. This article is protected by copyright. All rights reserved.
July 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28714107/the-braf-and-nras-mutation-prevalence-in-dermoscopic-subtypes-of-acquired-naevi-reveals-constitutive-mapk-pathway-activation
#9
J M Tan, L N Tom, K Jagirdar, D Lambie, H Schaider, R A Sturm, H P Soyer, M S Stark
BACKGROUND: Acquired naevi can have unique dermoscopic patterns that correspond to distinct microanatomical growth patterns. Previous studies on acquired naevi stratified according to dermoscopic pattern, focused on the frequency of somatic BRAF mutations, whereas NRAS mutations remained to be elucidated. OBJECTIVES: To investigate the BRAF and NRAS mutation prevalence and activation of the MAPK pathway in distinct dermoscopic subtypes of acquired naevi. METHODS: Common mutations present in BRAF and NRAS were assessed in 40 globular, reticular, and peripheral rim of globules (PG) subtypes of acquired naevi from 27 participants (19 male, 8 female; mean age 46...
July 17, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28714085/neural-control-of-sweat-secretion-a-review
#10
REVIEW
Y Hu, C Converse, M C Lyons, W H Hsu
Humans have 4 million exocrine sweat glands, which can be classified into two types: eccrine and apocrine glands. Sweat secretion is a constitutive feature, which is directly involved in thermoregulation and metabolism. Sweat secretion is regulated by both the central nervous system(1) and autonomic nervous system.(2) In peripheral areas, the ANS, especially the sympathetic nervous system (SNS), mediates the transmission of neurotransmitters to sweat glands. Two principal chemical mediators, acetylcholine and noradrenaline (NA)/adrenaline (ADR), are released by the SNS, which stimulate sweat secretion...
July 17, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28714061/establishing-and-prioritising-research-questions-for-the-prevention-diagnosis-and-treatment-of-hair-loss-excluding-alopecia-areata-the-hair-loss-priority-setting-partnership
#11
A Macbeth, J Tomlinson, A Messenger, K Moore-Millar, C Michaelides, A Shipman, J Kassim, J Brockley, W Szczecinska, P Farrant, R Robinson, J Rodgers, J Chambers, S Upadhyaya, M Harries
BACKGROUND: Hair and scalp problems are common. Unfortunately, many uncertainties exist around the most effective management and treatments strategies for these disorders. OBJECTIVES: To identify uncertainties in hair loss management, prevention, diagnosis and treatment that are important to both people with hair loss and healthcare professionals. METHODS: A hair loss priority setting partnership was established between patients, their carers and relatives, and healthcare professionals to identify the most important uncertainties in hair loss...
July 17, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28707317/acral-lentiginous-melanoma-a-skin-cancer-with-unfavourable-prognostic-features-a-study-of-the-german-central-malignant-melanoma-registry-cmmr-in-2050-patients
#12
Y Teramoto, U Keim, A Gesierich, G Schuler, E Fiedler, T Tüting, C Ulrich, U Wollina, J C Hassel, R Gutzmer, S Goerdt, C Zouboulis, U Leiter, T K Eigentler, C Garbe
BACKGROUND: Acral lentiginous melanoma (ALM) is one of the four major subtypes in cutaneous melanoma (CM). Although ALM has a poorer prognosis than other CM subtypes, the prognostic factors of ALM have been verified only in small-sized cohorts because of the low incidence of ALM worldwide. OBJECTIVES: To investigate clinical characteristics of ALM and to evaluate their prognostic values based on a large dataset from the Central Malignant Melanoma Registry (CMMR) of the German Dermatologic Society...
July 14, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28703284/brentuximab-vedotin-in-cd30-cutaneous-lymphoma-how-do-we-treat-how-shall-we-treat-a-review-of-the-literature
#13
REVIEW
R Stranzenbach, E Dippel, M Schlaak, R Stadler
Brentuximab vedotin is an antibody-drug conjugate that brings the antimicrotubule agent monomethyl auristatin E into CD30-expressing cells. Some prior studies could demonstrate good efficacy in cutaneous lymphomas. The standard therapeutic scheme is 1.8mg/kg every 3 weeks. Background of this work is the fact that cutaneous lymphoma has a different pathophysiology, and a dynamic other than systemic lymphoma. The objectives of this review were to get an overview of the currently used therapeutic regimen, and to check whether dose reduction or modified time intervals could benefit in a similar activity with less toxicity...
July 13, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28672053/a-genome-wide-association-study-suggested-that-the-mitogen-activated-protein-kinase-14-gene-mapk14-is-associated-with-diabetic-foot-ulcer
#14
W Meng, A Veluchamy, H L Hébert, A Campbell, H M Colhoun, C N A Palmer
BACKGROUND: Diabetic foot ulcer (DFU) is a devastating complication of diabetes. OBJECTIVES: We aimed to identify genetic contributors of DFU based on a genome-wide association study approach using a Scottish diabetic cohort. METHODS: A genome-wide association approach was applied. A case was defined as a diabetic patient (type 1 or type 2) who had ever been recorded in the linked e-health records as having a foot ulcer (current or previous) in at least one foot as well as a positive result of the monofilament test in the longitudinal e-health records...
July 3, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28667760/agree-ii-assessments-of-recent-acne-treatment-guidelines-how-well-do-they-reveal-trustworthiness-as-defined-by-the-institute-of-medicine-iom-criteria
#15
E A Eady, A M Layton, J Sprakel, B W M Arents, Z Fedorowicz, E J van Zuuren
BACKGROUND: Up-to-date, trustworthy guidelines are a widely relied-upon means of promoting excellent patient care. OBJECTIVES: To determine the quality of recently published acne treatment guidelines by utilizing the Appraisal of Guidelines for Research and Evaluation (AGREE) II Reporting Checklist, the US Institute of Medicine's (IOM) criteria of trustworthiness, Lenzer et al's red flags and CheckUp. METHODS: Systematic searches were conducted in bibliographic databases, guideline depositories and using Google(™) to identify acne treatment guidelines published since 2013...
July 1, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28667759/experiences-of-rosacea-and-its-treatment-an-interpretative-phenomenological-analysis
#16
S A Johnston, M Krasuska, A Millings, A C Lavda, A R Thompson
BACKGROUND: Whilst rosacea is a chronic skin condition, the condition can often have a large psychosocial impact on the individual. There is therefore a need to understand the experience of living with rosacea from the patient perspective. OBJECTIVES: To examine the experience of living with rosacea and the experience of seeking and receiving treatment. METHODS: Nine participants took part in semi-structured interviews, which were analysed using interpretative phenomenological analysis...
July 1, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28667753/invasive-dermatophyte-infection-with-trichophyton-interdigitale-is-associated-with-prurigo-induced-pseudoperforation-and-a-stat3-mutation
#17
J K Simpson, P Fröbel, S L Seneviratne, M Brown, D M Lowe, B Grimbacher, M Fliegauf, L Fearfield
Invasive dermatophyte infection, with extention beyond the dermis, in immunocompetent hosts is exceptionally rare. Dermatophytes are keratinophilic and are usually confined to the stratum corneum, hair and nails. Susceptibility to dermatophyte infections is incompletely understood but inherited mutations in key signaling pathways of the innate immune system have been identified.(1) We report the first case of an invasive dermatophyte infection associated with abrupt onset of a prurigo induced pseudoperforation and a loss of function mutation in Signal transducer and activator of transcription 3 (STAT 3)...
July 1, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28667747/lack-of-response-to-intravenous-sodium-thiosulfate-in-three-cases-of-extensive-connective-tissue-disease-associated-calcinosis-cutis
#18
P Song, N M Fett, J Lin, J F Merola, M Costner, R A Vleugels
Dystrophic calcinosis cutis is a debilitating condition of calcium salt deposition in the skin often occurring in association with connective tissue disease (CTD). Available treatments for calcinosis cutis are unsatisfactory, but given the recent use of topical and intralesional sodium thiosulfate (STS) to treat calcifying disorders, we sought to describe the use of intravenous (IV) STS for CTD-associated dystrophic calcinosis cutis. We report three patients with longstanding and extensive CTD-associated calcinosis cutis treated with IV STS after having failed multiple prior therapies...
July 1, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28667745/a-hyaluronic-acid-based-microneedle-patch-to-treat-psoriatic-plaques-a-pilot-open-trial
#19
LETTER
J H Lee, Y S Jung, G M Kim, J M Bae
Psoriasis, a common, chronic, relapsing, inflammatory skin disease characterised by multiple erythematous papules and plaques with silvery scales, affects 0.5-3% of the world's population. Recently, great advances have been made in the treatment of psoriasis, including the introduction of targeted biological agents.(1) However, topical treatment remains important; most patients have mild disease affecting less than 2% of the body surface area.(2) This article is protected by copyright. All rights reserved.
July 1, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28667744/european-heart-score-may-underestimates-cardiovascular-risk-after-assessing-cardiovascular-disease-with-carotid-ultrasound-in-hidradenitis-suppurativa
#20
LETTER
I González, J C Pascual, D Corona, P Hispán, I Betlloch
Hidradenitis suppurativa (HS) is chronic recurrent inflammatory disease affecting intertriginous areas, especially the axilla and the groin(1) . It is characterized by painful, deep-seated, inflamed lesions, including nodules, abscesses, and sinus tracts(2) . A recent meta-analysis found an association between HS and traditional cardiovascular (CV) risk factors and metabolic syndrome(3) . This article is protected by copyright. All rights reserved.
July 1, 2017: British Journal of Dermatology
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