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British Journal of Dermatology

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https://www.readbyqxmd.com/read/29341104/hair-cortisol-is-elevated-in-erythropoietic-protoporphyria-patients-and-correlates-with-body-mass-index-and-quality-of-life
#1
I Suijker, M Savas, E F C van Rossum, J G Langendonk
No abstract text is available yet for this article.
January 17, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29341069/reliability-and-validity-of-iscoreb-instrument-for-scoring-clinical-outcomes-of-research-for-epidermolysis-bullosa
#2
A L Bruckner, D L Fairclough, J A Feinstein, I Lara-Corrales, Anne W Lucky, Jakub Tolar, Elena Pope
BACKGROUND: Epidermolysis bullosa (EB) is a group of rare and currently incurable genetic blistering disorders. As more pathogenic driven therapies are being developed, the need for EB-specific validated outcomes measures designed for use in clinical trials is becoming important. OBJECTIVES: We previously reported on development of an instrument for scoring clinical outcomes of research for Epidermolysis Bullosa (iscorEB), a new combined clinician and patient reported outcomes tool...
January 17, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29341065/the-use-of-methotrexate-in-adolescents-contraception-confidentiality-and-consent
#3
LETTER
L Griffin, S Ryan, C Hackett, B Ramsay
The British Association of Dermatologist's recently published guidelines for safe and effective prescribing of methotrexate address on- and off-licence use in adults and children,1 but should more attention be paid to the group in between, adolescents? This article is protected by copyright. All rights reserved.
January 17, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29341063/localised-inflammatory-reactions-at-sites-of-subcutaneous-methotrexate-injections-during-treatment-with-ultraviolet-b
#4
LETTER
S Muthiah, F Charlton, P M Farr
Ultraviolet B (UVB) phototherapy may be used in combination with methotrexate to treat psoriasis. When given in high doses as chemotherapy, methotrexate can induce a "radiation recall" reaction where a rash develops at sites of previous exposure to sunlight or radiotherapy, and where keratinocyte necrosis is a prominent histopathological finding1 . However, this reaction does not seem to occur when methotrexate, given orally in conventional dermatological doses, is combined with UVB2, 3 . This article is protected by copyright...
January 17, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29341072/epidermal-melanocytes-of-segmental-vitiligo-show-altered-expression-of-e-cadherin-but-not-p-cadherin
#5
LETTER
C Grill, B Laila, A Rubod, Z Aktary, K Ezzedine, A Taieb, Y Gauthier, L Larue, V Delmas
Vitiligo is the most common pigmentation disorder, with a worldwide prevalence of 1%. The loss of melanocytes from the skin is the main clinical feature of patients with vitiligo, resulting in depigmentation macules. Vitiligo has been classified into two major forms: non-segmental vitiligo (NSV) and segmental vitiligo (SV). NSV lesions are generally bilateral or symmetrically scattered over the entire body. Onset may occur at any age, but most patients develop vitiligo before 40 years of age, and the depigmentation evolves over time...
January 16, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29341062/reflectance-confocal-microscopy-for-the-diagnosis-of-langerhans-cell-histiocytosis
#6
LETTER
C Chiaverini, F Le Duff, A Deville, N Cardot-Leccia, J P Lacour, P Bahadoran
Langerhans cell histiocytosis (LCH) is a rare proliferative disease occurring in young children. The most affected organs are the bones and the skin (1). The diagnosis of LCH relies on histopathology. Reflectance confocal microscopy (RCM) is a non-invasive imaging technique used to diagnose skin cancer (2). We report that in three children RCM examination of cutaneous lesions of LCH showed specific signs correlated to histopathology. This article is protected by copyright. All rights reserved.
January 16, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29336019/computerized-planimetry-to-assess-clinical-responsiveness-in-a-phase-ii-randomized-trial-of-topical-r333-for-discoid-lupus-erythematosus
#7
J K Presto, L G Okon, R Feng, D J Wallace, R Furie, D Fiorentino, V P Werth
BACKGROUND: R333 is a topical janus kinase and spleen tyrosine kinase inhibitor being evaluated for discoid lupus erythematosus (DLE) treatment. There is no validated measure to assess area of active DLE lesions. OBJECTIVES: To evaluate R333 efficacy and assess a technique to measure responsiveness. METHODS: 54 DLE patients were randomized in a double blind design to R333 or placebo. The primary endpoint was the proportion of patients achieving ≥50% decrease in erythema and scale based on lesional CLASI for all treated lesions at week 4...
January 16, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29336013/systematic-review-of-atopic-dermatitis-disease-definition-in-studies-using-routinely-collected-health-data
#8
REVIEW
M P Dizon, A M Yu, R K Singh, J Wan, Mary-Margaret Chren, Carsten Flohr, J Silverberg, D J Margolis, S M Langan, K Abuabara
BACKGROUND: Routinely collected electronic health data (RCD) obtained for administrative and clinical purposes are increasingly used to study atopic dermatitis (AD). Methods for identifying AD patients in RCD differ, and it is unknown how this might affect study results. OBJECTIVES: We sought to evaluate how AD patients have been identified in studies using RCD, to determine whether these methods were validated, and to estimate how the method for identifying AD patients affected variability in prevalence estimates...
January 16, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29336008/dermatology-training-across-the-globe
#9
LETTER
C Barber, K St Claire, K A Ashack, R P Dellavalle
Dermatology residency program rankings often stem from assessments by practicing physicians or evaluations of scholarly achievements such as grants and publicatons.1-3 Such rankings, however, are continuously changing, and fail to account for the specific missions of dermatology training programs.2 Additionally, a global comparison of dermatology training requirements and a worldwide understanding of the ideal dermatology curriculum remains missing from the literature. Therefore, this study aims to compare and contrast accreditation requirements for dermatology training programs across the world...
January 16, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29336016/could-conjunctivitis-in-dupilumab-treated-atopic-dermatitis-patients-be-caused-by-colonization-with-demodex-and-increased-il-17-levels-reply-from-authors
#10
LETTER
M de Bruin-Weller, N M H Graham, G Pirozzi, B Shumel
In studies in atopic dermatitis (AD), dupilumab has been associated with higher rates of conjunctivitis compared with placebo. Consistent with previous studies, in LIBERTY AD CAFÉ (NCT02755649), all cases but one were mild or moderate, most (62-89%) were recovered/resolved or recovering/resolving by end of treatment, and no patients permanently discontinued study treatment because of conjunctivitis.1 No patients reported atopic keratoconjunctivitis in this study. This article is protected by copyright. All rights reserved...
January 15, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29333670/pustular-psoriasis-and-related-pustular-skin-diseases
#11
REVIEW
H Bachelez
Patients with pustular psoriasis or related pustular diseases may have genetic abnormalities impairing the function of key players of the innate skin immune system. Recently, identification of these abnormalities has changed the paradigm of several of these diseases. These include generalized pustular psoriasis, palmoplantar pustular psoriasis and acrodermatitis continua of Hallopeau, and also drug-induced acute exanthematous generalized pustular eruption. Identified mutations in IL36RN, CARD14 and AP1S3 in different groups of patients lead to enhanced inflammatory cascade in several cellular subtypes including keratinocytes, and to the recruitment and activation of neutrophils and macrophages...
January 15, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29333668/a-photonumeric-scale-for-the-assessment-of-atrophic-facial-photodamage
#12
J Ayer, A Ahmed, E Duncan-Parry, P Beck, T W Griffiths, R E B Watson, C E M Griffiths
BACKGROUND: Photonumeric scales have consistently shown superiority over descriptive equivalents. They have the advantage of providing a consistent visual frame of reference by minimising variability in perception and subjectivity. A photonumeric scale to assess hypertrophic facial photodamage already exists. However, there is currently no objective measure for atrophic facial photodamage. To address this, we have devised a nine-point photonumeric standardised scale. OBJECTIVES: To design, test and validate a photonumeric scale for the assessment of atrophic facial photodamage against a descriptive scale for the same indication...
January 15, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29333603/could-conjunctivitis-in-dupilumab-treated-atopic-dermatitis-patients-be-caused-by-colonization-with-demodex-and-increased-il-17-levels
#13
LETTER
J P Thyssen
de Bruin-Weller et al., reported alarmingly high rates of unspecified and allergic conjunctivitis in trial patients with moderate-to-severe atopic dermatitis (AD) who underwent treatment with dupilumab; an antibody that inhibits signaling of IL-4 and IL-13.1 Importantly, the exact pathogenic mechanism behind incident conjunctivitis in dupilumab-treated patients is unclear. While all, but one case, were considered to be of mild or moderate severity, and most resolved after treatment discontinuation, ocular complications may ultimately deprive AD patients from effective treatment with dupilumab...
January 15, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29330859/differential-effects-of-phototherapy-adalimumab-and-betamethasone-calcipotriol-on-effector-and-regulatory-t-cells-in-psoriasis
#14
I S Kotb, B J Lewis, R N Barker, A D Ormerod
BACKGROUND: Psoriasis is a chronic T cell-mediated skin disease with marked social and economic burdens. Current treatments are unsatisfactory, with unpredictable remission times and incompletely understood modes of action. Recent advances in our understanding of the pathogenesis of psoriasis identify the imbalance between CD4+ T effector cells, particularly the T helper (Th) 17 subset, and regulatory T cells (Treg) as key to the development of psoriatic lesions, and therefore a novel therapeutic target...
January 12, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29330857/reduction-of-hyaluronan-and-increased-expression-of-hybid-kiaa1199-correlate-with-clinical-symptoms-in-photoaged-skin
#15
H Yoshida, A Nagaoka, A Komiya, M Aoki, S Nakamura, T Morikawa, R Ohtsuki, T Sayo, Y Okada, Y Takahashi
BACKGROUND: Hyaluronan (HA) metabolism in skin fibroblasts is mediated by HYBID (HYaluronan Binding protein Involved in hyaluronan Depolymerisation, KIAA1199) and HA synthases 1/2 (HAS1/2). However, photoageing-dependent changes in HA and their molecular mechanisms, and the relationship between HA metabolism and clinical symptoms in photoaged skin remain elusive. OBJECTIVES: We examined amount, size and tissue distribution of HA and expression levels of HYBID and HAS1/2 in photoaged skin, and analysed their relationships to the degree of photoageing...
January 12, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29330851/a-case-of-xeroderma-pigmentosum-complementation-group-c-with-diverse-clinical-features
#16
LETTER
T Masaki, E Nakano, K Okamura, R Ono, K Sugasawa, M-H Lee, T Suzuki, C Nishigori
Xeroderma pigmentosum (XP) is an autosomal recessive disease characterized by sensitivity to sunlight and increased risk of skin cancers. XP is classified into seven nucleotide excision repair-deficient types (A-G) and a variant type1 . Differential diagnosis of XP from other genetic pigmentary disorders such as dyschromatosis symmetrica hereditaria (DSH) and dyschromatosis universalis hereditaria (DUH) should be considered, which is sometimes difficult without DNA repair tests or a genetic diagnosis2 . DSH and DUH are autosomal dominant diseases characterized by hypo-and hyperpigmented maculae...
January 12, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29330849/expression-of-yap-and-taz-in-molluscum-contagiosum-virus-infected-skin
#17
LETTER
H-M Seo, G T Moon, Y M Song, H Y Gee, Y M Park, J Y Lee, J H Lee
The Hippo signaling pathway, which is highly conserved in organisms ranging from Drosophila to mammals, plays a key role in organ size control, cellular proliferation, survival and tumorigenesis1 Yes-associated protein (YAP) is the major downstream effector of Hippo signaling pathway and transcriptional co-activator with PDZ-binding motif (TAZ) is a YAP paralog. Recently, Zhang et al. found that YAP/TAZ acts as natural inhibitors of TANK binding kinase 1 (TBK1), which is a key component for cytosolic nucleic acid sensing antiviral defense and antiviral physiology2 This article is protected by copyright...
January 12, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29330848/cultured-allogeneic-fibroblast-injection-versus-fibroblasts-cultured-on-amniotic-membrane-scaffold-for-dystrophic-epidermolysis-bullosa-treatment
#18
H Moravvej, F Abdollahimajd, M-H Naseh, Z Piravar, E Abolhasani, N Mozafari, H Niknejad
BACKGROUND: Different methods of fibroblast application have been examined to treat recessive dystrophic epidermolysis bullosa (RDEB). OBJECTIVE: To compare the effects of intradermal injection of cultured allogeneic fibroblasts in healing RDEB wounds with that of fibroblasts seeded on amniotic membrane scaffolds (FAMS) or standard wound care (SWC) with Vaseline gauze as controls. MATERIALS &METHODS: Seven patients were recruited, and seven wounds were assessed in each patient: three wounds were treated with injection of intradermal fibroblasts, three were treated with FAMS, and one was dressed with SWC...
January 12, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29330846/oral-propranolol-for-infantile-haemangioma-may-be-associated-with-transient-gross-motor-delay
#19
LETTER
C Mahon, G Heron, D Perkins, A Drage, O Wargon
Oral propranolol, first-line therapy for infantile haemangioma (IH) threatening functional impairment or cosmetic disfigurement, readily crosses the blood-brain barrier. Subsequently therefore, there are concerns about potential effects on infant development. Phillips et al. followed 200 children prescribed propranolol, observing sedative effects during treatment and reported gross motor abnormalities in 13 of 188 children, 7 of whom had delayed age (17-20 months) at first walking. This article is protected by copyright...
January 12, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29328510/a-multidimensional-assessment-of-the-burden-of-psoriasis-results-from-a-multinational-dermatologist-and-patient-survey
#20
C E M Griffiths, S J Jo, L Naldi, R Romiti, E Guevara-Sangines, T Howe, G Pietri, I Gilloteau, C Richardson, H Tian, M Augustin
BACKGROUND: Psoriasis is a chronic, immune-mediated disease, characterised by symptoms that include itching and skin pain and is often associated with comorbidities. Patients have a substantial detriment to quality of life (QoL) and work productivity with associated cost burden. OBJECTIVE: To investigate the incremental burden of comorbidities, itch, and affected body areas among systemic eligible patients with psoriasis, using a multinational survey of dermatologists and their psoriasis patients...
January 12, 2018: British Journal of Dermatology
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