journal
MENU ▼
Read by QxMD icon Read
search

British Journal of Dermatology

journal
https://www.readbyqxmd.com/read/27905098/are-neutrophilic-dermatoses-autoinflammatory-disorders
#1
REVIEW
T K Satoh, M Mellett, E Contassot, L E French
Neutrophils constitute essential players in inflammatory responses and are the first line of defence against harmful stimuli. However, dysregulation of neutrophil homeostasis can result in excessive inflammation and subsequent tissue damage. Neutrophilic dermatoses are a spectrum of inflammatory disorders characterized by skin lesions resulting from a neutrophil-rich inflammatory infiltrate in the absence of infection. The exact molecular pathophysiology of neutrophilic dermatoses has long been poorly understood...
November 30, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27893168/not-every-patient-needs-triglyceride-check-but-all-can-get-pancreatitis-a-systematic-review-and-clinical-characterization-of-isotretinoin-associated-pancreatitis
#2
LETTER
D Opel, O N Kramer, M Chevalier, M Bigby, J Albrecht
Isotretinoin is a medication to treat primarily nodulocystic acne vulgaris. A serious complication is pancreatitis, either idiosyncratic, and not preventable or predictable; or due to elevated triglycerides. Triglyceride are elevated in practically all patients on isotretinoin, but may not be abnormal, or too minimally elevated to pose a pancreatitis risk.(1) Elevated triglycerides are not a cause of arteriosclerotic risk. but can be a marker.(2,3) Objective of this review was to clinically characterize patients with isotretinoin induced pancreatitis particularly due to hypertriglyceridemia to evaluate what monitoring is sensible...
November 28, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27893156/reply-to-a-phase-ii-randomized-controlled-trial-of-nicotinamide-for-skin-cancer-chemoprevention-in-renal-transplant-recipients-reply-from-the-authors
#3
LETTER
D L Damian, A J Martin, R A Scolyer, A C Chen, G M Halliday
We thank Yélamos et al. for their interest in our nicotinamide chemoprevention studies.(1) Some of their comments are pertinent, while others are based on a flawed interpretation of our data. Zhao(2) previously commented on (nonsignificant) numerical differences in the frequency of adverse-event term groupings (mucocutaneous infections) between the placebo and nicotinamide groups in our ONTRAC chemoprevention study (Oral Nicotinamide To Reduce Actinic Cancer).(3) As stated previously, chance remains a highly plausible explanation for the numerically higher mucocutaneous infections in the nicotinamide arm and also, for example, for the numerically lower respiratory infections observed in the nicotinamide arm...
November 28, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27893155/health-cards-by-google-dermatologist-review-of-inclusivity-and-utility-of-the-medical-search-application
#4
LETTER
J D Ransohoff, K Y Sarin
One in twenty Google web searches are related to medical conditions(1) indicating the prominent role of the internet as a resource for medical information. Indeed, 72% of internet users report searching online for medical conditions; 77% began with Google, Bing, or Yahoo.(2) While 53% additionally sought physician consultation, 46% did not.(3) Responding to its place in the medical community, in 2015 Google partnered with academic, government, and business-based ventures to develop "health cards" for searched disorders, and, in summer 2016, debuted a "related conditions" generator, suggesting diagnoses related to input disorders or symptoms...
November 28, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27893152/an-evaluation-of-high-stage-cutaneous-squamous-cell-carcinoma-outcomes-by-gender
#5
LETTER
J Duran, F C Morgan, P S Karia, C D Schmults
Data from the World Health Organization indicate that global overall age-adjusted cancer incidence and mortality rates are 1.2- and 1.5-fold higher in men as compared to women, respectively.(1) Non-melanoma skin cancer (NMSC) is the most common cancer among white populations, yet the prognostic significance of gender remains unclear.(2) A possible relationship may exist given that in melanoma, women have a lower mortality risk as compared to men.(3,4) This article is protected by copyright. All rights reserved...
November 28, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27888511/dermatological-content-of-uk-undergraduate-curricula-where-are-we-now
#6
LETTER
A Yaakub, S N Cohen, M Singh, J M R Goulding
Given its impact, prevalence and especially its prominence in primary care (1) , the importance of all medical graduates developing knowledge and awareness of skin disease ought to go without saying. Yet a previous audit of undergraduate teaching against the recommendations of the British Association of Dermatologists (BAD) identified important omissions in the courses of some medical schools (2) . We recently undertook a survey of all medical schools in the UK and Ireland to investigate whether this had changed...
November 26, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27880000/reply-to-a-phase-2-randomised-controlled-trial-of-nicotinamide-for-skin-cancer-chemoprevention-in-renal-transplant-recipients
#7
LETTER
O Yélamos, A C Halpern, M A Weinstock
We have read with interest the paper by Chen et al. in which oral nicotinamide is used to prevent keratinocyte carcinomas (KC; basal and squamous cell carcinomas of the skin) in renal transplant patients.(1) The current study suggests nicotinamide is safe and effective to prevent the development of KC in this high-risk group, similarly to a study by the same group in non-transplant patients (ONTRAC study, Oral Nicotinamide To Reduce Actinic Cancer). This article is protected by copyright. All rights reserved...
November 23, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27878819/vitiligo-and-depression-a-systematic-review-and-meta-analysis-of-observational-studies
#8
REVIEW
Y Lai, Y W Yew, C Kennedy, R A Schwartz
BACKGROUND: Vitiligo is a common depigmenting disorder with profound psychosocial impacts. Previous observational studies have suggested a link between vitiligo and psychiatric morbidity such as depression. Variability in study design, however, makes it difficult to accurately quantify the relationship between vitiligo and depression. OBJECTIVES: This study aimed to investigate the underlying prevalence and risk of depression among vitiligo patients. METHODS: A comprehensive search of Medline, Embase, and Cochrane library databases was conducted...
November 23, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27873316/aberrant-gene-expression-with-deficient-apoptotic-keratinocyte-clearance-may-predispose-to-polymorphic-light-eruption
#9
LETTER
S Lembo, J L M Hawk, G M Murphy, K Kaneko, A R Young, J M McGregor, S L Walker, R A Palmer
Polymorphic light eruption (PLE) is the commonest photodermatosis, demonstrating intermittently appearing non-scarring pruritic, erythematous papules, vesicles or plaques on patient skin within hours of ultraviolet radiation (UVR) exposure. It depends on genetic susceptibility as well as environmental UVR exposure and is apparently a failure of normal UVR-induced immunosuppression in the presence of simultaneously produced skin photoneoantigens(1,2) , with a resulting increased immune response. Reduced TNF-α, IL-4 and IL-10 expression, a lack of neutrophils, reduced T-helper-1/T-helper-2 skewing and reduced Langerhans cell migration have also been demonstrated in UVB-irradiated PLE skin(3) ...
November 22, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27873303/cutis-laxa-acquisita-novel-insights-into-impaired-elastic-fiber-regeneration
#10
LETTER
P Gkogkolou, K Hildebrandt, S Broekaert, D Metze, G Sengle, M Böhm
Cutis laxa (CL) is a rare disorder affecting elastic fiber formation(1) . The disease is disfiguring and involvement of big vessels in lung and heart often leads to severe complications. CL occurs as an inherited and acquired form, cutis laxa acquisita (CLA). While in the inherited form most mutations have been identified in genes for elastic fiber components like elastin (2) , fibulin-4 (3) , fibulin-5 (4) , or LTBP-4 (5) the pathogenesis of CLA remains poorly understood. Clinically, there often is an association between CLA and paraproteinemia (1) ...
November 22, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27873302/ultrasonographic-findings-can-identify-pseudoprogression-under-nivolumab-therapy
#11
K Imafuku, H Hata, S Kitamura, T Yanagi, H Shimizu
'Pseudoprogression' is often seen in patients with melanomas who are treated with immune-checkpoint inhibitors such as nivolumab or ipilimumab. We sometimes evaluate metastatic lesions by imaging tests such as CT or PET-CT. 'Pseudoprogression' usually occurs upon the initial administration, which may make it difficult for the physician to determine the disease condition. In our two cases of metastatic melanoma treated with nivolumab (anti-PD-1 antibody), we examined the ultrasonography (US) of target lesions that could be accessed from the body surface, such as those of the regional lymph node or subcutaneous metastasis...
November 22, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27873301/regarding-frontal-fibrosing-alopecia-possible-association-with-leave-on-facial-skin-care-products-and-sunscreens-a-questionnaire-study
#12
LETTER
A Dhana, F Gumedze, N Khumalo
Using a matched case-control study design, Aldoori et al (2016) report a possible association between frontal fibrosing alopecia (FFA) and the regular use of sunscreens and facial skin care products.(1) We commended the authors for drawing attention to potential environmental causes of this disfiguring condition. However, several methodological limitations drew our attention. First, we are concerned about selection bias. Control subjects were selected from hospital staff through advertisements and from friends and family of the authors...
November 22, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27870003/prognostic-impact-of-the-putative-cancer-stem-cell-markers-abcg2-cd133-aldh1a1-and-cd44v7-8-in-metastatic-melanoma
#13
LETTER
L Speigl, N Janssen, B Weide, G Pawelec, C Shipp
Despite recent therapeutic advances, a diagnosis of metastatic melanoma still foreshadows a grim prognosis for the majority of patients. One of the factors believed to be associated with the failure of current conventional cancer therapies are the so-called Cancer Stem Cells (CSCs). CSCs share common features with corresponding tissue stem cells, such as self-renewal capacity and the ability to give rise to progeny with the potential to proliferate and differentiate. Therapeutically targeting CSCs may thus eliminate the root cause of the cancer, however this would require the accurate identification of markers distinguishing CSCs from normal cells...
November 21, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27868192/the-association-between-drugs-and-bullous-pemphigoid
#14
LETTER
C W X Tan, Y Pang, B Sim, T Thirumoorthy, S M Pang, H Y Lee
Drug-induced bullous pemphigoid (DIBP) is often poorly defined in the existing literature from the classic, spontaneous form of bullous pemphigoid (BP). The pathogenesis is unclear and the association between bullous pemphigoid and various medications is tenuous(1-2) .Commonly reported associations include neuroleptics(3-4) and diuretics(3, 5) with more recent literature drawing attention to dipeptidyl peptidase-4 inhibitors(6) .Strength of drug causality associations is generally determined by factors such as latency between drug initiation and onset of disease, epidemiological risk, effects of withdrawal/re-challenge...
November 21, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27868183/hydroxychloroquine-prescribing-and-monitoring-practices-among-irish-dermatologists-and-rheumatologists
#15
LETTER
E Gilhooley, C Feighery, S M Collins
Hydroxychloroquine (HCQ) is an effective drug that is widely used to treat connective tissue and autoimmune diseases. Overall, it has an excellent safety profile; however, its most potentially serious and irreversible side-effect is retinal toxicity. The Royal College of Ophthalmologists (RCO) published their recommendation on HCQ and ocular toxicity screening in 2009. This article is protected by copyright. All rights reserved.
November 21, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27864930/atopic-dermatitis-patients-with-filaggrin-loss-of-function-mutations-show-good-but-lower-responses-to-immunosuppressive-treatment
#16
LETTER
E Roekevisch, M M G Leeflang, M E Schram, L E Campbell, W H Irwin McLean, S Kezic, J D Bos, P I Spuls, M A Middelkamp-Hup
Filaggrin (FLG) mutations are a strong risk factor to develop atopic dermatitis (AD). However, the relationship between FLG mutations and treatment outcome in AD has not been thoroughly studied. To investigate whether FLG mutations influence immunosuppressive treatment outcome in AD, we studied the effect of FLG mutations in patients with severe AD participating in a single blinded randomized controlled trial (RCT) with methotrexate (MTX) or azathioprine (AZA) during a 24 weeks treatment regimen.((1)) Two years after randomization buccal mucosa swabs were collected from 36 of the 42 RCT patients (86%) to determine the FLG genotype status (R501X, 2282del4, R2447X, S3247X and 3321delA mutations)...
November 19, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27864925/drug-induced-pyoderma-gangrenosum-a-model-to-understand-the-pathogenesis-of-pyoderma-gangrenosum
#17
REVIEW
B C Wu, E D Patel, A G Ortega-Loayza
Pyoderma gangrenosum (PG) is a rare auto-inflammatory condition in which the alteration of neutrophil function and the innate immune response play key roles in its pathogenesis. Cases of PG have been reported in patients being treated with certain medications, which may help us to understand some of the possible pathways involved in the etiology of PG. The aim of this review is to review the cases of PG triggered by certain drugs and try to thoroughly understand the pathogenesis of the disease. To accomplish this, a PubMed search was completed using the following words: pyoderma gangrenosum, neutrophilic dermatosis, pathophysiology, drug-induced pyoderma gangrenosum...
November 19, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27864820/response-to-a-functional-mechanistic-study-of-the-effect-of-emollients-on-the-structure-and-function-of-the-skin-barrier
#18
LETTER
V A Hart
I read, with interest, the recent article by Danby et al(1) on the effectiveness of two commercially available emollients, Diprobase cream and Doublebase gel, in relation to the structure and function of the skin barrier in atopic dermatitis. This article is protected by copyright. All rights reserved.
November 19, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27864837/risk-factors-for-non-purulent-leg-cellulitis-a-systematic-review-and-meta-analysis
#19
REVIEW
M Quirke, F Ayoub, A McCabe, F Boland, B Smith, R O'Sullivan, A Wakai
Non-purulent cellulitis is an acute bacterial infection of the dermal and subdermal tissues that is not associated with purulent drainage, discharge or abscess. The objective of this systematic review and meta-analysis (SRMA) was to identify and appraise all controlled observational studies that have examined risk factors for the development of non-purulent cellulitis of the leg (NPLC). A systematic literature search of electronic databases and grey literature sources was performed in July 2015. The Newcastle-Ottawa Scale (NOS) was used to assess methodological quality of included studies...
November 18, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27864821/effect-of-alterations-in-apoptotic-pathway-on-development-of-metabolic-syndrome-in-patients-with-psoriasis-vulgaris
#20
S Korkmaz, H Korkmaz
OBJECTIVES: The purpose of this study is to evaluate the role of changes in gene expression of apoptosis activators (BAX, cytocrome-c [cyt-c], and caspase-3) and apoptosis inhibitors (BCL2, survivin, cyclin D1 [CCND1], SOD, catalase 3 [CAT], glutathione synthetase [GS], heat shock protein [HSP]27, HSP60, HSP70, and HSP90) on the development of metabolic syndrome (MetS) in patients with psoriasis vulgarins. METHODS: Fifty patients with psoriasis were enrolled in the study, 25 of whom had MetS...
November 18, 2016: British Journal of Dermatology
journal
journal
20056
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"