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British Journal of Dermatology

F L Nowrouzian, G Lina, E Hodille, E Lindberg, B Hesselmar, R Saalman, I Adlerberth, A E Wold
According to the hygiene hypothesis, insufficient immune activation by microbes increases the risk of allergy development. Staphylococcus aureus, which is part of the skin and gut microbiota of infants in Western countries, produces a variety of T-cell-activating enterotoxins, called superantigens. We investigated whether early (0-2 months of age) gut colonisation by S. aureus strains that carry specific superantigens and adhesins was related to subsequent development of atopic eczema in a Swedish birth-cohort...
October 19, 2016: British Journal of Dermatology
E Teasdale, I Muller, M Santer
BACKGROUND: Childhood eczema is very common and can have substantial impact on quality of life. One of the main treatments is topical-corticosteroids, but these are often under-used by parents/carers for reasons that include concerns about safety. OBJECTIVES: To explore understandings and concerns about topical-corticosteroids amongst parents/carers of children with eczema who had posted messages in online forums. METHODS: A qualitative study of messages and their resultant discussions about topical-corticosteroids for childhood eczema posted by parents/carers on two UK-based discussion forums...
October 18, 2016: British Journal of Dermatology
Hadar Lev-Tov, Larissa Larsen, Rasiq Zackria, Harvind Chahal, Daniel B Eisen, Raja K Sivamani
Photodynamic therapy (PDT) is a common method of treating actinic keratoses (AKs) that compares favorably to other treatment methods.(1,2) However, treatment is limited by prolonged incubation times required for the medication to penetrate the stratum corneum.(3) Microneedles (MNs) are micrometer scale needles that are capable of puncturing the stratum corneum with minimal pain.(4,5) They have been utilized for various applications, including enhanced drug delivery.6 Few studies have evaluated MNs in conjunction with PDT for AKs...
October 12, 2016: British Journal of Dermatology
A M C Coneo, A R Thompson, A Lavda
BACKGROUND: Individuals with visible skin conditions often experience stigmatisation and discrimination. This may trigger maladaptive responses such as feelings of anger and hostility with negative consequences to social interactions and relationships. OBJECTIVES: The present study aimed to identify psychosocial factors contributing to aggression levels in dermatology patients. METHODS: Data was obtained from ninety-one participants recruited from out-patient clinics in the north of England, UK...
October 11, 2016: British Journal of Dermatology
G Richtig, L Byrom, R Kupsa, H Schaider, R Hofmann-Wellenhof, I H Wolf, H P Soyer, E Richtig
Whether or not pregnancy favours the occurrence and growth of melanoma is a source of controversy in the literature. Several case reports have shown dramatic courses of diseases in pregnancy. We present a case of a 36-year-old woman with multiple naevi with one melanoma detected in 2009 in the first trimester and a second primary melanoma in 2010 in the third trimester of her pregnancy. Both lesions have been present for at least 5 years and have been interpreted as dysplastic naevi. Because of their growth during pregnancy they were removed...
October 8, 2016: British Journal of Dermatology
F Larese Filon, S Plazzotta, F Rui, M Mauro, P De Michieli, C Negro
The incidence of OCD (occupational contact dermatitis) in different European Countries and USA ranges between 0.5 and 1.9 cases per 1000 workers per year. (1,2,3) OCD is lowering in the last 10-15 years, with incidence rate that varies between 1.2 to 0.56 cases per 1000 person-years from 1993 to 1996 in Germany (1,3) and from 0.29 to 0.1 cases per 1000 from 1997 to 2008 in a Czech study.(4) Incidence of notified occupational skin diseases for health care workers (HCWs) was 3.1 cases per 1000 workers per year in USA, 1...
October 8, 2016: British Journal of Dermatology
M J van Geel, M E Otero, E M G J de Jong, P C M van de Kerkhof, M M B Seyger
BACKGROUND: The Simplified Psoriasis Index (SPI) is a three-domain assessment measure for psoriasis, including separate indicators of current severity (SPI-s), psychosocial impact (SPI-p), and past history and interventions (SPI-i). There are two complementary versions available designed for completion by a health professional (proSPI) or by patient self-assessment (saSPI). The validity and reliability of proSPI versus saSPI have already been demonstrated in adults. To date, validated severity measures for pediatric psoriasis do not exist...
October 8, 2016: British Journal of Dermatology
J Tan, L Almeida, A Bewley, B Cribier, N Dlova, R Gallo, G Kautz, M Mannis, H Oon, M Rajagopalan, M Steinhoff, D Thiboutot, P Troielli, G Webster, Y Wu, E van Zuuren, M Schaller
BACKGROUND: Rosacea is currently diagnosed by consensus-defined primary and secondary features and managed by subtype. However, individual features (phenotypes) can span multiple subtypes, which has implications for clinical practice and research. Adopting a phenotype-led approach may facilitate patient-centred management. OBJECTIVES: To advance clinical practice by obtaining international consensus to establish a phenotype-led rosacea diagnosis and classification scheme with global representation...
October 8, 2016: British Journal of Dermatology
E H Modalsli, B O Åsvold, P R Romundstad, A Langhammer, M Hoff, S Forsmo, L Naldi, M Saunes
BACKGROUND: An association between psoriasis and osteoporosis has been reported. OBJECTIVE: In a large prospective population-based Norwegian study, we investigated whether psoriasis was associated with increased risk of forearm or hip fracture. We also investigated the cross-sectional association between psoriasis and bone mineral density (BMD) T-score in a sub-population. METHODS: Hospital-derived fracture data from Nord-Trøndelag County 1995-2013 was linked to psoriasis-information, BMD measurements and lifestyle factors from the third survey of the Nord-Trøndelag Health Study 2006-08 (HUNT3), socioeconomic data from the National Education Database and use of medication from the Norwegian Prescription Database...
October 8, 2016: British Journal of Dermatology
O Maiques, A Macià, S Moreno, C Barceló, M Santacana, A Vea, J Herreros, S Gatius, E Ortega, J Valls, B J Chen, D Llobet-Navas, X Matias-Guiu, C Cantí, R M Marti
BACKGROUND AND OBJECTIVES: Cutaneous malignant melanoma arises from transformed melanocytes de novo or from congenital or acquired melanocytic nevi. We have recently reported that T-type Ca(2+) channels (TTCs) are upregulated in human melanoma and play an important role on cell proliferation. The aim of this study was to describe for the first time in formalin-fixed-paraffin-embedded tissue the immunoexpression of TT-Cs in biopsies of normal skin, acquired melanocytic nevi and melanoma, in order to evaluate their role in melanomagenesis and/or tumor progression, their utility as prognostic markers and their possible use in targeted therapies...
October 8, 2016: British Journal of Dermatology
O D van Cranenburgh, S B W Nijland, R Lindeboom, J de Korte, M A de Rie, J A Ter Stege, C A C Prinsen
BACKGROUND: Although considered relevant, little is known about satisfaction with treatment and health-related quality of life (HRQoL) among lichen sclerosus (LS) patients. OBJECTIVES: In a cross-sectional study, we aimed to examine 1) satisfaction with treatment, 2) patient characteristics associated with satisfaction, and 3) HRQoL in Dutch LS patients. METHODS: Members of the Dutch LS Patient Association (N=750) were invited to complete a web-based survey...
October 8, 2016: British Journal of Dermatology
M Kabuto, N Fujimoto, T Takahashi, T Tanaka
BACKGROUND: hile the frequency of IL-10-producing B cells (B10 cells) is reported to have an inverse correlation with disease activity in some human autoimmune diseases, the association between B10 cells and autoimmune blistering diseases (AIBD) has not been well-evaluated. Although several phenotypes of human regulatory B cells have been proposed, the most appropriate one was not established. OBJECTIVE: This study aimed to evaluate B10 cells in AIBD including their phenotypes...
October 7, 2016: British Journal of Dermatology
I Hoorens, L Brochez
No abstract text is available yet for this article.
October 7, 2016: British Journal of Dermatology
T Hashimoto, A Ohzono, K Teye, S Numata, S Hiroyasu, D Tsuruta, T Hachiya, K Kuroda, M Hashiguchi, T Kawakami, N Ishii
BACKGROUND: IgE autoantibodies are considered to be involved in pathogenesis of bullous pemphigoid (BP), particularly inflammatory and erythematous phenotypes. OBJECTIVE: To develop reliable ELISAs for detection of IgE autoantibodies to both BP180 and BP230 in BP sera, and to compare the ELISA results with clinical features. METHODS: We used commercially available IgG ELISAs to develop IgE ELISAs for both BP180 and BP230. To determine the influence of excess amount of IgG autoantibodies, all normal and BP sera were tested before and after IgG adsorption...
October 7, 2016: British Journal of Dermatology
P K C Goon, D C Greenberg, L Igali, N J Levell
Potential skin cancer referrals constitute a dominant and disproportionate number of dermatology referrals from primary care in the UK. The majority of dermatology and pathology departments in the UK are struggling to cope with rising demand for diagnostic and treatment services and recent austerity measures, with cutbacks in all public service budgets have also affected the NHS. In this study, we have analysed data from the East of England, specifically East Norfolk and Waveney, and estimated the number of cases for SCCs and BCCs of skin for 2020 and 2025...
October 7, 2016: British Journal of Dermatology
J R Marsden, R Fox, N M Boota, M Cook, K Wheatley, L Billingham, N Steven
BACKGROUND: Topical imiquimod is sometimes used for lentigo maligna (LM) in-situ melanoma instead of surgery, but frequency of cure is uncertain. Pathological complete regression (pCR) is a logical surrogate marker for cure after imiquimod, although residual LM and atypical melanocytic hyperplasia may not be reliably distinguished. A trial comparing imiquimod versus surgery might be justified by a high imiquimod pCR rate. OBJECTIVES: Primary: to estimate pCR rate for LM following imiquimod...
October 6, 2016: British Journal of Dermatology
A Sakai, Y Shimomura, O Ansai, Y Saito, K I Tomii, Y Tsuchida, H Iwata, H Ujiie, H Shimizu, R Abe
Bullous pemphigoid (BP) is a common autoimmune subepidermal blistering disease characterized by autoantibodies against BP180 and/or BP230, both of which are a major structural component of hemidesmosomes. In most cases, autoantibodies against NC16A domain of BP180 (BP180-NC16A) are detected, and as such the pathomechanisms of BP have been becoming clear.(1) However, the initial triggers of the disease are still largely unidentified. Nevertheless, it has been shown that certain medications including antibiotics, neuroleptics, and NSAIDs can be associated with the development of BP...
October 6, 2016: British Journal of Dermatology
S Aguilar-Duran, A Panthagani, L Naysmith, S A Holme
No abstract text is available yet for this article.
October 6, 2016: British Journal of Dermatology
F R Ali, E E Craythorne, F Al-Niaimi
No abstract text is available yet for this article.
October 6, 2016: British Journal of Dermatology
K Fattouh, S Debarbieux, L Depaepe, M Amini-Adle, B Balme, L Thomas
in situ or minimally invasive melanoma can be treated by nonamputative wide excision of the nail unit followed by a skin graft, performed by a dermatologic surgeon, with an excellent cosmetic and functional result that does not impair the prognosis.(1-2) We previously published a preliminary study showing a good correlation between perioperative Reflectance Confocal Microscopy (RCM) and histopathology of the nail matrix in case of subungual melanoma (SUM)(3) . Since then, we used perioperative in vivo RCM in our centre, after informed consent of patient, during surgical exploration of 30 consecutive cases of suspicious MS between 1/11/2012 and 31/03/2016...
October 3, 2016: British Journal of Dermatology
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