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British Journal of Dermatology

V Eleftheriadou, I Hamzavi, A Pandya, P Grimes, J E Harris, R H Huggins, H W Lim, N Elbuluk, A Tovar-Garza, A F Nahhas, T Braunberger, K Ezzedine
BACKGROUND: There is no cure nor firm clinical recommendations for the treatment of vitiligo. One of the main issues is the heterogeneity of outcome measures used in randomised controlled trials (RCTs) for vitiligo. OBJECTIVE: This study was conducted with an aim to define successful repigmentation from patients' point of view and propose how and when repigmentation should be evaluated in clinical trials in vitiligo. METHODS: We conducted 3 workshops with vitiligo patients and their parents/care givers...
July 21, 2018: British Journal of Dermatology
F M N Forton
No abstract text is available yet for this article.
July 19, 2018: British Journal of Dermatology
L Heinz, E Bourrat, P Vabres, J Thevenon, A Hotz, S Hörer, J Küsel, A D Zimmer, S Alter, R Happle, J Fischer
Focal dermal hypoplasia (FDH, Goltz syndrome, MIM: #305600) constitutes a rare multisystem genetic disorder of the skin, skeleton, teeth and eyes with considerable variation in the clinical features. FDH is transmitted as an X-linked dominant trait and is caused by mutations in PORCN. In males, hemizygous PORCN mutations are lethal in utero. Around 300 cases have been reported in the literature to date. About 10% of them are males presenting either Klinefelter syndrome (karyotype 47, XXY) or mosaicism of a postzygotic mutation...
July 19, 2018: British Journal of Dermatology
M Akdeniz, S Gabriel, A Lichterfeld-Kottner, U Blume-Peytavi, J Kottner
BACKGROUND: Transepidermal water loss (TEWL) is one of the most important skin barrier characteristics. Higher TEWL is usually associated with skin barrier impairments and lower TEWL with healthy skin. OBJECTIVES: The aim was to update an existing systematic review and meta-analysis to provide TEWL reference values for healthy skin in adults. DATA SOURCES: The databases MEDLINE and EMBASE and other sources were searched. METHODS: This update includes studies identified by the two searches which combined cover the period from 1947 until April 13th 2017...
July 19, 2018: British Journal of Dermatology
R Waas, S Meggit
After commencing mepacrine for discoid lupus erythematosus (DLE), 2 women (aged 39 and 58 years) developed interstitial lung disease (ILD) confirmed on high resolution CT and full lung function testing. The ILD resolved completely in one case and nearly completely in the second individual after both stopping mepacrine and treating with a course of oral corticosteroids (and mycophenolate mofetil (MMF) in the second case). Differential diagnoses for this presentation include infection, drug reaction and ILD related to a systemic connective tissue disease...
July 19, 2018: British Journal of Dermatology
S Inoue, N Okiyama, M Shobo, S-I Motegi, H Hirano, Y Nakagawa, A Saito, Y Nakamura, Y Ishitsuka, Y Fujisawa, R Watanabe, M Fujimoto
Myositis-specific autoantibodies (MSAs) are closely associated with distinct clinical subsets of dermatomyositis (DM). In 2007, a novel MSA-reacting small ubiquitin-like modifier activating enzyme (SAE) was identified in some patients with DM characterised by extensive rash and dysphagia1 . Owing to the low proportion of patients with DM having the anti-SAE antibody (1.5%-3% in Asia2-4 and 6.7%-8.4% in Europe5-7 among all patients with DM), their clinical features have not been sufficiently analysed. This article is protected by copyright...
July 19, 2018: British Journal of Dermatology
A Kanzaki, Y Kato, T Kariya, Y Kanda, K Shirai, T Arai, R Tsuboi
The incidence of basal cell carcinoma (BCC), the most common form of skin cancer, has been rising1 . Since BCC progresses slowly in most cases and rarely metastasises, nonsurgical treatment is feasible. One such treatment uses the topical medication, imiquimod, which is a common treatment for superficial basal cell carcinoma (BCC) in the UK and USA. This article is protected by copyright. All rights reserved.
July 17, 2018: British Journal of Dermatology
C Serra-Guillén, E Nagore, E Bancalari, S Kindem, O Sanmartín, B Llombart, C Requena, I Serra-Guillén, L Calomarde, A Diago, E Bernia, C Guillén
We designed a prospective, randomized, intraindividual, investigator-blinded clinical trial comparing methyl-5-aminolaevulinate (MAL) cream and 5-aminolaevulinic acid nanoemulsion (BF-200 ALA) in the treatment of actinic keratosis (AK) with photodynamic therapy (PDT). Eligible patients had to have two symmetric, comparable areas of skin (left and right) containing at least eight non-hypertrophic AK lesions on the face or scalp.1 The study was approved by the ethics committee at the Instituto Valenciano de Oncología and written informed consent was obtained from all participants...
July 17, 2018: British Journal of Dermatology
S Polubothu, M Glover, S E Holder, V A Kinsler
An eight-year-old girl was under the care of dermatology with congenital ichythosis. Her past history was of full term birth as a collodion baby, the first child of unrelated healthy parents. In the neonatal period she developed generalized ichthyosiform erythroderma. This article is protected by copyright. All rights reserved.
July 14, 2018: British Journal of Dermatology
L Santiago, B R Ferreira, L Ramos, M Gonçalo
First and second line therapy of chronic spontaneous urticaria (CSU) include second-generation H1-antihistamines, but more than 50% of CSU shows little benefit1,2 . Omalizumab and ciclosporin are recommended as 3rd and 4th line treatments1 , respectively. Despite its inferior safety profile compared to omalizumab1,2 , efficacy of ciclosporin has been shown in controlled trials and case series, with approximately 60% of patients with severe CSU having a good response3 . This article is protected by copyright...
July 14, 2018: British Journal of Dermatology
R Parisi, R T Webb, C E Kleyn, M J Carr, N Kapur, C E M Griffiths, D M Ashcroft
BACKGROUND: Psychological distress among people with psoriasis may lead to elevated risks of suicide and non-fatal self-harm. OBJECTIVES: To investigate psychiatric comorbidity, psychotropic medication prescribing and risk of suicidality in people with psoriasis. METHODS: A cohort of patients with psoriasis (1998-2014) was delineated using the Clinical Practice Research Datalink, with linkage to Hospital Episode Statistics and Office for National Statistics mortality records...
July 14, 2018: British Journal of Dermatology
A Connolly, V Grandi, C M Stefanato, R Palmer, A Weir, S Whittaker
fingolimod, a disease-modifying treatment licenced (FDA approved in 2010) for relapsing-remitting multiple sclerosis (RRMS), is a modulator for four of the five known sphingosine-1-phosphate (S1P) receptor subtypes widely expressed in tissues including endothelial cells, lymphocytes, smooth muscle and neural cells (1). S1P receptor type 1 (S1PR1) is predominantly expressed by lymphocytes and represents the key molecular target for the therapeutic effect of fingolimod in multiple sclerosis (MS), by acting as a functional antagonist of the S1P receptor causing inhibition of lymphocyte egress from lymph nodes...
July 14, 2018: British Journal of Dermatology
K Papier, L G Gordon, K Khosrotehrani, N Isbel, S Campbell, A Griffin, A C Green
BACKGROUND: The incidence of skin cancer in organ transplant recipients (OTRs) is very high due mainly to long-term immunosuppressive therapy. The problem is particularly severe for organ transplant recipients living in Queensland, Australia, resulting in significant mortality. OBJECTIVE: To describe the experience of the first dedicated outpatient high-throughput Transplant Skin Clinic in Queensland. METHODS: This prospective evaluation study was conducted at a newly established, outpatient transplant skin cancer surgery and surveillance clinic...
July 13, 2018: British Journal of Dermatology
J Feng, Y Kim, M L Kornides, A L McRee, D Mays, M M Asgari, M B Gilkey
Indoor tanning greatly increases skin cancer risk, with exposure before age 35 associated with a 60% increase in the risk of melanoma. Unfortunately, despite recent declines, indoor tanning remains common among U.S. adolescents with 1.2 million high school students reporting use in 2015. Parental permission to tan and positive parental attitudes toward tanning are strong predictors of adolescent indoor tanning. To guide outreach efforts, we sought to identify factors associated with positive parental attitudes toward adolescent indoor tanning...
July 13, 2018: British Journal of Dermatology
C Zhong, H Song, A Weiss, W-H Tan, S Coury, J T Huang
Infantile myofibromatosis (IM) is a common benign tumor of childhood, characterized by proliferation of myofibroblasts in the skin, muscle, subcutaneous tissue, bone, or viscera. Dermatologic manifestations range from smooth telangiectatic nodules to ulcerated lesions. We report an unusual case of a patient with multiple intramuscular myofibromas presenting with extensive reticulated vascular changes and subcutaneous atrophy. Biopsy of affected skin revealed a heterozygous gain of function mutation in the PDGFRB gene, consistent with the diagnosis of IM...
July 12, 2018: British Journal of Dermatology
P Theut Riis, O B Pedersen, V Sigsgaard, C Erikstrup, H M Paarup, K R Nielsen, K S Burgdorf, H Hjalgrim, K Rostgaard, K Banasik, H Ullum, G B Jemec
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent inflamed nodules. No pathognomonic test is available for HS, hence the diagnosis is based on three clinical criteria. We used a questionnaire previously developed for diagnosis of HS to estimate the cross-sectional prevalence and characterize HS patients in the Danish Blood Donor Study cohort. METHOD: A questionnaire containing the HS screening questions, the Major Depression Inventory, the Short Form-12, as well as questions about height, weight and drinking habits was answered by 27,725 blood donors...
July 12, 2018: British Journal of Dermatology
L Hulshof, D P Hack, Q C J Hasnoe, B Dontje, I Jakasa, C Riethmüller, W H I McLean, W M C van Aalderen, B Van't Land, S Kezic, A B Sprikkelman, M A Middelkamp-Hup
BACKGROUND: Atopic dermatitis (AD) affects children of all skin types, most research is focused on Caucasians with light skin types. Studies investigating biomarkers in AD patients with dark skin types are lacking. OBJECTIVES: To explore skin barrier and immune response biomarkers in stratum corneum (SC) tape strips from AD children with different skin types. METHODS: Tape strips were collected from lesional and non-lesional forearm skin of 53 AD children and 50 control children...
July 10, 2018: British Journal of Dermatology
A Alex, S Frey, H Angelene, C D Neitzel, J Li, A J Bower, D R Spillman, M Marjanovic, E J Chaney, J L Medler, W Lee, L S Vasist Johnson, S A Boppart, Z Arp
BACKGROUND: In this Phase I clinical trial, the spatial bio-distribution and residency of GSK2894512 within the epidermis and dermis of healthy human participants was investigated non-invasively using fluorescence lifetime imaging microscopy (FLIM). Two topical drug formulations containing 1% GSK2894512 were applied to the right and left forearms of 6 participants for 7 consecutive days, followed by 7 days of observation for residency. OBJECTIVE: FLIM images were obtained daily throughout the study approximately every 24 hours...
July 10, 2018: British Journal of Dermatology
C Chijiwa, S Takeoka, M Kamata, H Uchida, S Fukaya, K Hayashi, A Fukuyasu, T Tanaka, T Ishikawa, T Ohnishi, Y Tada
Several papers reported that tumor necrosis factor (TNF)-α inhibitors such as adalimumab (ADA) induced interstitial pneumonia (IP) in patients with rheumatoid arthritis1-3 . We here retrospectively investigated the changes in serum KL-6 levels, which should be elevated in patient with IP4 , in psoriasis patients receiving secukinumab (SEC), anti-interleukin (IL)-17A antibody, in addition to patients receiving ADA. This article is protected by copyright. All rights reserved.
July 9, 2018: British Journal of Dermatology
S X Gu, X Mo, A L Zhang, J Liu, M E Coyle, S Ye, Z Wen, N E Cranswick, C C Xue, D Chen
Atopic eczema (AE) or atopic dermatitis is a chronic and relapsing inflammatory skin disease. The prevalence and burden of AE are increasing globally. Systemic immunomodulating medications including corticosteroids or immunosuppressive drugs are efficacious agents for difficult-to-treat or refractory moderate or severe AE, but are not used routinely due to safety concerns. Some AE patients reported using complementary and alternative medicines including Chinese herbal medicine (CHM). A Cochrane systematic review of 28 studies involving 2,306 AE participants found an oral CHM formula could improve quality of life in AE children...
July 7, 2018: British Journal of Dermatology
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