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British Journal of Dermatology

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https://www.readbyqxmd.com/read/28334422/increase-in-sensory-sensitivity-around-but-not-in-the-central-part-of-the-hyperkeratotic-papule-in-lichen-amyloidosis
#1
LETTER
T Andoh, T Shimizu
Lichen amyloidosis (LA) is an itchy skin disorder characterized by amyloid deposits in the superficial dermis. Pruritus is the presenting symptom in 90% of LA patients.(1) However, the underlying mechanisms and mediators of pruritus in LA remain unclear. One LA patient complained of severe pruritus in the hyperkeratotic papules, especially around the papule. This article is protected by copyright. All rights reserved.
March 23, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28334421/burden-of-respiratory-comorbidities-in-patients-with-atopic-dermatitis-and-psoriasis
#2
LETTER
Y M F Andersen, A Egeberg, G H Gislason, L Skov, J P Thyssen
Atopic dermatitis (AD), a skin disease with an estimated lifetime prevalence of up to 20%, represents a major global healthcare burden.(1) Patients with AD have a propensity to develop asthma due to a combination of genetic, immunological and environmental factors, yet descriptive studies on the impact of respiratory diseases in adults with AD are scarce.(2) In contrast, psoriasis, another chronic inflammatory skin disease, has been associated with respiratory comorbidities such as chronic obstructive pulmonary disease (COPD)(3) , asthma(4) and obstructive sleep apnea (OSA)...
March 23, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28317091/staphylococcus-aureus-colonization-in-atopic-eczema-and-its-association-with-filaggrin-gene-mutations
#3
M-L Clausen, S M Edslev, P S Andersen, K Clemmensen, K A Krogfelt, T Agner
BACKGROUND: Atopic dermatitis (AD) is a prevalent disease with significant impact on physical health and quality of life. Staphylococcus aureus (S. aureus) has been directly correlated to disease severity, and may also be a contributing causal factor in the pathogenesis of AD. The primary aim of the present study was to assess differences in S. aureus colonization in AD patients with and without filaggrin gene (FLG) mutations. Secondarily, to assess disease severity in relation to S. aureus colonization...
March 19, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28314058/a-chronic-recurrent-disease-course-of-dermatomyositis-is-associated-with-autoantibodies-against-tif1%C3%AE
#4
LETTER
S Meisterfeld, N Röber, K Conrad, S Beissert, M Aringer, C Günther
Dermatomyositis (DM) is a rare autoimmune disease with high clinical variability in terms of cutaneous and muscle involvement as well as disease duration. DM severely impacts the quality of life of the patients and may be life threatening. This is primarily due to lung involvement and the 3.0 to 7.7 fold increased relative risk for cancer compared to the general adult population(1;2) . This article is protected by copyright. All rights reserved.
March 17, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28314054/a-cross-sectional-survey-of-the-nature-and-correlates-of-sleep-disturbance-in-people-with-psoriasis
#5
A L Henry, S D Kyle, A Chisholm, C E M Griffiths, C Bundy
BACKGROUND: Research suggests that sleep disturbance is common in psoriasis. Despite 32 studies conducted in sleep, many demonstrate methodological flaws, often using unvalidated measurement, with no study examining multiple dimensions of sleep-wake functioning. Moreover, research has yet to comprehensively examine the range of physical and psychological factors that may affect sleep in people with psoriasis. OBJECTIVE: To characterise sleep disturbance using validated measures and identify physical and psychological predictors of sleep quality in people with psoriasis...
March 17, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28303566/authorship-selection-in-industry-sponsored-publications-of-dermatology-clinical-trials
#6
LETTER
M Tauber, C Paul
The issue of conflict of interest management and authorship has been the subject of debates and recommendations over the past 15 years(1-7) . Some grey areas persist concerning the definition of authorship in industry-sponsored clinical trials (IRCT)(8) . The objective of the present study was to better understand this process. This article is protected by copyright. All rights reserved.
March 17, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28301708/diffuse-large-b-cell-lymphoma-developing-in-erythrodermic-cutaneous-t-cell-lymphoma-a-case-series
#7
LETTER
B C Y Chan, C M Stefanato, M T Moonim, S L Morris, P Fields, D Dasgupta, A Therianou, S J Whittaker
Mycosis fungoides (MF) and its leukemic form, Sezary Syndrome (SS), are the most common forms of cutaneous T-cell lymphoma (CTCL). CTCL is associated with an increased risk of secondary cancers, including lymphomas.(1) Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma (NHL) in the western world and can involve both nodal and extranodal sites including the skin.(2) DLBCL is invariably associated with an aggressive course if left untreated. This article is protected by copyright...
March 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28301691/interleukin-32-is-highly-expressed-in-lesions-of-hidradenitis-suppurativa
#8
R Thomi, D Yerly, N Yawalkar, D Simon, C Schlapbach, R E Hunger
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. Its immunopathogenic mechanisms are still poorly understood. Previous studies could demonstrate that the pro-inflammatory cytokine Interleukin-32 (IL-32) is implicated in the pathogenesis of other inflammatory diseases. OBJECTIVES: The aim of our study was to investigate the tissue expression and systemic levels of IL-32 as well as its cellular sources in HS patients in comparison to healthy donors and to patients suffering from two other inflammatory skin diseases: psoriasis (PS) and atopic dermatitis (AD)...
March 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28301679/cutaneous-adverse-drug-reactions-referrals-to-a-liaison-dermatology-service
#9
LETTER
Y Teo, S Walsh, D Creamer
Adverse drug reactions (ADRs) are a common consequence of medications, with an estimated 10-20% of all hospitalised patients experiencing a drug side effect(1-2) ; those affecting the skin being the most frequently recorded. The need to optimise management of cutaneous ADRs has been underlined by the recent publication of NICE Guidelines on Drug Allergy(3) , setting out a range of standards to enhance the diagnosis and management of patients developing allergic reactions to drugs. This study was undertaken to assess the number of drug allergy referrals, and the types of cutaneous drug reaction encountered in the in-patient population...
March 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28301048/reaching-complete-or-near-complete-resolution-of-psoriasis-benefit-and-risk-considerations
#10
LETTER
A Blauvelt, C E M Griffiths, M Lebwohl, U Mrowietz, L Puig, S Ball, L Zhang, E Edson-Heredia, M Warner, B Zhu, C-Y Lin, E Nikaï, D Dey, L Mallbris, K Reich
The incremental benefits of obtaining higher levels of skin clearance for patients with psoriasis have been established across several patient reported outcomes (PROs). Patients who obtain clear or almost clear skin are more likely to report no impact of psoriasis on health-related quality of life (HRQoL) and other symptom measures. While the benefits of obtaining higher skin clearance have been reported with different therapeutic agents, the question of whether the benefits of such high levels of response may be offset by an increased risk for adverse outcomes has not been fully explored with biologics...
March 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28301047/response-to-frontal-fibrosing-alopecia-in-men-an-association-with-facial-moisturisers-and-sunscreen
#11
LETTER
L C Strazzulla, L Avila, K Lo Sicco, J Shapiro
We applaud Debroy-Kidambi et al for repeating their questionnaire study in male patients to determine possible environmental exposures that could be contributing to the increasing incidence of frontal fibrosing alopecia (FFA). In fact, in our own clinic we have noted that patients are often as interested in the possible causes of this condition as they are in available treatment methods. The discrepancy in facial moisturizer use between men with FFA compared to controls (94% versus 32%, p<0.0001) and the consistent use of primary sunscreens among FFA patients (35% versus 4%, p=0...
March 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28301045/beneficial-effect-of-ustekinumab-in-familial-pityriasis-rubra-pilaris-with-a-new-missense-mutation-in-card14
#12
S M Lwin, C-K Hsu, L Liu, H-Y Huang, N J Levell, J A McGrath
Pityriasis rubra pilaris (PRP) represents a group of rare chronic inflammatory skin disorders in which ~1 in 20 affected individuals show autosomal dominant inheritance. In such cases, there may be gain-of-function mutations in CARD14, encoding caspase recruitment domain-containing protein 14 (CARD14) that activates the non-canonical nuclear factor-kappa B (NF-κB) pathway, thereby promoting cutaneous inflammation. Here, we report a mother and son with PRP due to a new missense mutation in CARD14 and describe the beneficial clinical effects of ustekinumab, a monoclonal antibody against interleukins-12 and -23, in both subjects...
March 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28301044/cutaneous-squamous-cell-carcinoma-and-the-park2-gene
#13
LETTER
R Inzelberg, E Friedman, E Azizi
We read with great interest the excellent review by Green and Olsen on the epidemiology of cutaneous squamous cell carcinoma of skin (cSCC). The authors reported that one of the genes found to be associated with SCC in GWAS studies is PARK2, and that its' function is unknown. Parkinson's disease (PD) literature may provide some insights to the contribution of PARK2 to skin cancers. PD patients are at higher risk than the general population for skin cancers. This article is protected by copyright. All rights reserved...
March 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28301043/a-topical-treatment-optimisation-programme-ttop-improves-clinical-outcome-to-calcipotriol-betamethasone-gel-in-psoriasis-results-of-the-64-week-multinational-randomized-phase-iv-study-in-1790-patients-pso-top
#14
K Reich, I Zschocke, H Bachelez, E M G J de Jong, P Gisondi, L Puig, R B Warren, C Ortland, U Mrowietz
BACKGROUND: Around two-thirds of psoriasis patients do not adhere to topical treatment. The 'Topical Treatment Optimisation Programme' (TTOP), a five-element tool, includes guidance for the conversation between dermatologists/nurses and patients, patient information material, telephone/email helpdesks and treatment reminders. It has been developed by patients and dermatologists to help increase adherence in psoriasis. OBJECTIVE: To compare TTOP with standard of care ('non-TTOP') within a large European investigator-initiated study, PSO-TOP (Clinicaltrials...
March 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28295198/analysis-of-disease-activity-categories-in-chronic-spontaneous-idiopathic-urticaria
#15
D Stull, D McBride, H Tian, A Gimenez Arnau, M Maurer, A Marsland, M-M Balp, S Khalil, C Grattan
BACKGROUND: Measurement of disease activity guides treatment of chronic spontaneous urticaria (CSU). A weekly Urticaria Activity Score-here, the average of twice-daily patient assessment of itch and hives scores summed over 1 week (UAS7TD )-measures severity from 0 to 42. Insufficient evidence exists whether disease activity states, defined by categorical UAS7TD scores, correlate with other patient-reported outcomes and treatment response. OBJECTIVE: To evaluate and compare categorical UAS7TD scores with selected measures of disease-related quality of life and impact...
March 13, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28295197/search-strategies-for-finding-systematic-reviews
#16
LETTER
D Grindlay
I have read with interest the 2017 article by F Gómez-García and colleagues called "Systematic reviews and meta-analyses on psoriasis: role of funding sources, conflict of interest, and bibliometric indices as predictors of methodological quality" published in the BJD. This study makes a very important point about the influence of funding sources and conflicts of interests on the methodological quality of systematic reviews. However, I have some concerns about the search strategy used to find systematic reviews for this analysis...
March 13, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28295200/isothiocyanates-are-important-as-haptens-in-contact-allergy-to-chloroprene-rubber
#17
A G Ramzy, K Lammintausta, M Matura, J B Christensson, U Nilsson, L Hagvall
BACKGROUND: Contact allergy to chloroprene rubber products is well known. Thiourea compounds are considered the cause of allergy, despite being non- or weak sensitizers. Diethylthiourea is commonly occurring in this type of products and can decompose to the sensitizer ethyl isothiocyanate. OBJECTIVES: To investigate the clinical importance of degradation products and metabolites from organic thioureas in contact allergy to chloroprene rubber with focus on isothiocyanates and isocyanates...
March 10, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28295196/dermatology-life-quality-index-dlqi-as-a-psoriasis-referral-triage-tool
#18
LETTER
Ausama Atwan, Vincent Piguet, Andrew Y Finlay, Nick A Francis, John R Ingram
Most primary care psoriasis referrals in the UK are triaged as 'routine', in part because of the prioritisation of skin cancer. As a result, patients with severe psoriasis may wait several months to be seen, enduring quality of life (QoL) impairment that could have been reduced. Furthermore some patients may spontaneously improve by the time they are seen by a specialist, making the appointment unnecessary at that time. Therefore, following approval from the local ethics committee, we conducted a prospective study to evaluate the usefulness of Dermatology Life Quality Index (DLQI) scores in triaging patients with psoriasis referred to our dermatology secondary health care services...
March 10, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28295195/arrhythmias-in-metastatic-melanoma-patient-treated-with-targeted-therapy-and-icd-implant
#19
LETTER
M Licciardello, M T Giura, G Rozzo, E Marra, P Fava, C Astrua, V Contu, P Lista, M T Fierro, P Quaglino, S Ribero
Metastatic melanoma is an aggressive and rapidly progressive disease. Heart metastases were shown in over 50% of autopsy. However, these metastases are usually clinically silent and reported in less than 2% of living patients(1.2) . There are no specific guidelines for the treatment of cardiac metastases as the therapeutic approach varies with the clinical features of the patient. This article is protected by copyright. All rights reserved.
March 10, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28295172/poor-agreement-between-a-mobile-phone-application-for-the-analysis-of-skin-lesions-and-the-clinical-diagnosis-of-the-dermatologist-a-pilot-study
#20
LETTER
R Nabil, W Bergman, N A Kukutsch
The use of mobile phone health applications (apps) has become very popular in the population. The SkinVision app (SVA) is the first skin cancer app with an European CE-certification.(1) This means that a product has met EU health, safety and environmental requirements.(2) SkinVision lets the consumer "take photos of moles and skin conditions to analyse for skin cancer risk".(1) Artificial intelligence is used to automatically interpret the modified image. Based on this analysis, it evaluates lesions as low (green), medium (yellow) or high risk (red)...
March 10, 2017: British Journal of Dermatology
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