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British Journal of Dermatology

D Leskur, J Bukić, A Petrić, L Zekan, D Rušić, A Šešelja Perišin, I Petrić, M Stipić, N Puizina-Ivić, D Modun
BACKGROUND: Sodium laurylsulphate (SLS) induced contact dermatitis is a commonly used model for testing effects of different topical formulations. Volar forearms are preferred testing site by the guidelines, but other anatomical locations were used in previous research, especially upper back, as the clinically used site for testing different antigens. OBJECTIVES: Aim of the present study was to investigate existence of anatomical variations of skin response to irritation and its' effects on response to treatment...
January 13, 2019: British Journal of Dermatology
E M Rehbinder, A J Winger, L Landrø, A Asarnoj, T L Berents, K H Carlsen, G Hedlin, C M Jonassen, B Nordlund, L Sandvik, H O Skjerven, C Söderhäll, R Vettukattil, K C L Carlsen
Atopic dermatitis (AD) usually begins in infancy, commonly involving the cheeks and extensor surfaces of the extremities. It is associated with a dysfunctional skin barrier, which can be measured as increased transepidermal water loss (TEWL) in both lesional and non-lesional skin in AD patients. Dry skin, a cardinal sign of AD, is associated with higher TEWL in adult AD patients. The documentation of the prevalence and manifestation of dry skin in infancy and its association to TEWL, is however limited. Therefore, we aimed to determine the prevalence of dry skin in early infancy and to assess if dry skin in general, or more specifically on cheeks and extensor surfaces of the extremities, was associated with dysfunctional skin barrier...
January 13, 2019: British Journal of Dermatology
M E Ogunsanya, S K Cho, A Hudson, B F Chong
BACKGROUND: Cutaneous lupus erythematosus (CLE) is a potentially disfiguring, chronic autoimmune disease with extremely variable skin manifestations, negatively affecting quality of life (QoL) of patients. Patient-reported outcome (PRO) measures used in assessing QoL in CLE patients have been either generic or developed without input from patients with CLE. OBJECTIVES: To demonstrate the reliability and validity of a disease-specific QoL measure for CLE - the cutaneous lupus erythematosus quality of life (CLEQoL)...
January 13, 2019: British Journal of Dermatology
J H Kim, J K Seok, Y M Kim, Y C Boo
BACKGROUND: Antimelanogenic peptides are potentially useful to treat hyperpigmentation, but many peptides have limited application because of high cost and/or low activity. OBJECTIVES: To identify small and potent peptide inhibitors of cellular melanin synthesis useful for cosmetic and medical applications. METHODS: A positional scanning synthetic tetrapeptide combinatorial library was used for screening of potentially active peptides. Antimelanogenic activities of the peptide pools and individual peptides were evaluated in B16-F10 melanoma cells and human epidermal melanocytes (HEMs) treated with alpha-melanocyte-stimulating hormone (α-MSH)...
January 13, 2019: British Journal of Dermatology
E C Noels, L M Hollestein, S van Egmond, M Lugtenberg, L P J van Nistelrooij, P Bindels, J van der Lei, R S Stern, T Nijsten, M Wakkee
BACKGROUND: The high prevalence of actinic keratosis (AK) requires optimal use of healthcare resources. OBJECTIVES: To gain insight in health care utilization and management of AK, by describing the healthcare utilization of people with AK in a population-based cohort and in a primary and secondary care setting. METHODS: A retrospective cohort study using three complementary data sources was conducted to describe the use of care, diagnosis, treatment, and follow-up of AK patients in the Netherlands...
January 12, 2019: British Journal of Dermatology
Y Wu, Y Sun, L Qiu, H Wang, Y Zhang, K Chen, H Li, H Gu, J Zhang, X-H Gao
Managing patients with vitiligo is no longer whether to treat or not to treat, but to decide what modalities are more appropriate. Both topical calcineurin inhibitors and 308-nm excimer laser (EL) were generally accepted to treat vitiligo, and the combination of the two achieved better efficacy.However, there has been no strict comparison of the two methods in treating facial/neck vitiligo. Here we conducted a multi-center,randomized, left-right comparative trial in face and/or neck vitiligo,between 2012 and 2014...
January 11, 2019: British Journal of Dermatology
M Tauber, P A Apoil, C Richet, J Laurent, G De Bonnecaze, E Mouchon, M Cassagne, M C Marguery, S Hegazy, M P Konstantinou, M Severino, C Uthurriague, F Giordano-Labadie, A Didier, C Paul
Dupilumab has demonstrated efficacy in atopic dermatitis (AD)1-3 , asthma4 , perennial allergic rhinitis5 and chronic sinusitis6 . The objectives of this prospective observational, single-centre study were to assess 1) dupilumab efficacy in real-life practice and 2) the evolution of atopic co-morbidities and specific immunoglobulin E (IgE) levels during dupilumab treatment. This article is protected by copyright. All rights reserved.
January 11, 2019: British Journal of Dermatology
D Thorel, A Delcampe, S Ingen-Housz-Oro, C Hajj, E Gabison, O Chosidow, P Wolkenstein, G Royer, K Ezzedine, M Muraine, J Gueudry
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute severe skin reactions with extensive apoptosis of the epidermis and mucous membranes. Ocular involvement occurs in up to 75% of patients at the acute phase, described as mild, moderate and severe involvement and may result in long-term severe sequelae with dryness, photophobia, cicatrising conjunctivitis complicated with corneal vascularisation and scarring, which may result in severe visual loss. The acute management of SJS/TEN ocular complications has not been codified...
January 11, 2019: British Journal of Dermatology
S McKenzie, P Zang, P Blackcloud, B Cohen, A Truong, S Worswick, J Arzeno
Mucormycosis is an aggressive infection caused by an angioinvasive fungus that results in significant human disease. It most commonly manifests as rhinocerebral, pulmonary, and cutaneous infections. Among healthcare-associated mucormycosis, cutaneous manifestations are the most common, accounting for >50% of infections. Although mucormycosis can remain limited to the skin, it has the potential to disseminate hematogenously if left unrecognized or untreated, particularly in patients with multiple risk factors...
January 11, 2019: British Journal of Dermatology
A Al-Janabi, Z K Jabbar-Lopez, C E M Griffiths, Z Z N Yiu
AIM: Gordon et al investigated the efficacy and safety of risankizumab (an anti-interleukin[IL]23p19 biologic) compared with ustekinumab (anti-IL12/23p40) and placebo in patients with moderate-to-severe chronic plaque psoriasis. This is a parallel group controlled study up to 16 weeks with a planned switch of the placebo group to risankizumab at 16 weeks. SETTING AND DESIGN: This study consisted of two replicate phase 3, double-blinded randomised-controlled trials (UltIMMa-1 and UltIMMa-2) conducted across 139 centres in Australia, Austria, Belgium, Canada, Czech Republic, France, Germany, Japan, Mexico, Poland, Portugal, South Korea, Spain and the USA...
January 11, 2019: British Journal of Dermatology
P R Hansen, J Lynggaard Isaksen, G Borut Jemec, C Ellervik, J Kim Kanters
Psoriasis has been associated with other autoimmune diseases, e.g. inflammatory bowel disease and autoimmune thyroid disease. These diseases may share genetic susceptibility loci and autoimmune mechanisms including interleukin-17-dependent pathways. However, the relationship between psoriasis and autoimmune thyroid disease remains unclear and a recent meta-analysis of available evidence concluded that more data are needed. This article is protected by copyright. All rights reserved.
January 10, 2019: British Journal of Dermatology
K J Mason, S Williams, Z Z N Yiu, K McElhone, D M Ashcroft, C E Kleyn, Z K Jabbar-Lopez, C M Owen, N J Reynolds, C H Smith, N Wilson, R B Warren, C E M Griffiths
BACKGROUND: The persistence and effectiveness of systemic therapies for moderate-severe psoriasis in current clinical practice are poorly characterised. OBJECTIVES: To systematically review observational studies investigating the persistence and effectiveness of acitretin, ciclosporin, fumaric acid esters (FAE) and methotrexate involving at least 100 adult patients with moderate-severe psoriasis, exposed to therapy for ≥3 months. METHODS: Medline, Embase, the Cochrane Library and PubMed were searched from 01/01/2007 to 01/11/2017 for observational studies reporting on persistence (therapy duration or the proportion of patients discontinuing therapy during follow-up) or effectiveness (improvements in Psoriasis Area and Severity Index [PASI] or Physician Global Assessment [PGA])...
January 10, 2019: British Journal of Dermatology
S L Soon, S F Ibrahim, S T Arron
Vismodegib is indicated for adults with metastatic or locally advanced basal cell carcinoma (BCC) inappropriate for surgery or radiotherapy. Neoadjuvant vismodegib has been reported to shrink locally advanced and high-risk BCC before surgery. It is unclear whether non-contiguous residual tumour remains after neoadjuvant treatment. This article is protected by copyright. All rights reserved.
January 9, 2019: British Journal of Dermatology
Y W Lee, C-H Won, K Jung, H-J Nam, G Choi, Y-H Park, M Park, B Kim
BACKGROUND: Transient receptor potential vanilloid subfamily, member 1 (TRPV1) may play an important role in pruritus and inflammation induction in atopic dermatitis (AD). The treatment effect of TRPV1 antagonist via topical application in patients with AD remains unknown. OBJECTIVES: To assess the clinical efficacy and safety of PAC-14028, a TRPV1 antagonist, via topical application in patients with AD. METHODS: In this 8-week, phase IIb, randomized, double-blind, multicentre, vehicle-controlled study, patients with mild-to-moderate AD were randomized to receive PAC-14028 cream 0·1%, 0·3%, 1·0% or vehicle cream twice daily...
January 8, 2019: British Journal of Dermatology
M Maarouf, C L Maarouf, G Yosipovitch, V Y Shi
INTRODUCTION: The epidermal barrier functions to limit skin infection and inflammation by inhibiting irritant and immunogen invasion. Abundant evidence suggests that psychological stress stemming from crowding, isolation, nicotine smoking, insomnia, mental arithmetic tasks, physical pain, real life-stressors (examinations and marital strain), and lack of positive personality traits may impart both acute and chronic epidermal dysfunction. MATERIALS/METHODS: A review of PubMed and EMBASE databases was conducted to identify all English case-control, cross-sectional, and randomized control trials that report the effect of stress on epidermal barrier function...
January 7, 2019: British Journal of Dermatology
L C J van Delft, B A B Essers, S Harnas, N W J Kelleners-Smeets
There are many effective treatment options for basal-cell carcinoma (BCC). To ensure a shared treatment decision, it is essential to understand patient preferences, values, and experience with treatments. We evaluated patients' recollections of the treatment choices for their BCC and what kind of information they valued most by doing a quantitative survey via the largest Dutch patient federation ('Patiëntenfederatie Nederland', PFN). The PFN includes a 25,000 member patient-panel; their medical history is not reported...
January 5, 2019: British Journal of Dermatology
D F Carr, C-W Wang, T Bellón, L Ressel, G Nwikue, V Shrivastava, W Bergfeld, A L Jorgensen, W-H Chung, M Pirmohamed
High-mobility group box 1 (HMGB1) is a damage-associated molecular-pattern protein indicative of cell/tissue injury and innate immune response. Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) are serious, immune-mediated skin-blistering conditions characterised by widespread keratinocyte death and epidermal detachment. The purpose of the study was to determine: a) serum and/or blister-fluid total HMGB1 levels in independent SJS/TEN cohorts: and b) HMGB1 expression in formalin-fixed, paraffin-embedded SJS/TEN skin vs...
January 5, 2019: British Journal of Dermatology
Z Jiyad, V Akhras
Longitudinal melanonychia is a pigmented longitudinal band on the nail plate and may occur due to melanocyte activation, nail matrix nevus, lentigo or subungual melanoma.1 In a racially diverse community, melanonychia is a relatively common presenting complaint. However, despite this, little is known about the incidence of melanoma in longitudinal melanonychia, as well as variations in management approaches. This article is protected by copyright. All rights reserved.
January 4, 2019: British Journal of Dermatology
M C Aichelburg, A Pinkowicz, C Schuster, B Volc-Platzer, A Tanew
Granuloma annulare (GA) is a benign cutaneous disease. Clinical variants include classic, generalized, perforating, subcutaneous and patch type GA. Patch GA shows a distinct clinical presentation of smooth erythematous to brownish macules surfacing on the extremities and trunk with no evidence of papules or induration. Diagnosis is usually made by histopathology revealing a pattern of interstitial GA. This article is protected by copyright. All rights reserved.
January 4, 2019: British Journal of Dermatology
N Enzan, A Kitadate, A Tanaka, K Matsue
Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of malignant lymphoma characterised by atypical lymphoid cell proliferation within small vessels. We previously reported that random skin biopsy (RSB) is useful for the early diagnosis of IVLBCL; we emphasised the importance of subcutaneous fat tissue in biopsied specimens because most IVLBCL lesions are found in the vessels of subcutaneous fat tissue. However, Maekawa et al. found that seven of nine patients (78%) had IVLBCL lesions in the dermis...
January 4, 2019: British Journal of Dermatology
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