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British Journal of Dermatology

E J van Zuuren, Z Fedorowicz, B W M Arents
Eczema is a chronic inflammatory skin disorder with considerable impact on quality of life. Emollients or moisturisers are widely recommended, but are these effective and safe? We searched for randomised controlled trials (RCTs) in the Cochrane Skin Group Specialised Register, CENTRAL in The Cochrane Library, Medline, Embase, LILACS, GREAT database and five trial registers to December 2015. We included 77 RCTs with 6603 participants. Seven studies (9.1%) were at low risk of bias, 34 (44.2%) at unclear and 36 (46...
April 22, 2017: British Journal of Dermatology
M J Ridd, A J L King, E Le Roux, A Waldecker, A L Huntle
Eczema is a common, long-term condition but inadequate support and information can lead to poor adherence and treatment failure. We have reviewed the international literature of interventions designed to promote self-management in adults and children with eczema. MEDLINE, MEDLINE in process, EMBASE, CINAHL and GREAT were searched from their inception to August 2016 for randomised controlled trials. Two authors independently applied eligibility criteria, assessed risk of bias for all included studies and extracted data...
April 22, 2017: British Journal of Dermatology
M M Asgari, L Shen, M M Sokil, I Yeh, E Jorgenson
BACKGROUND: Acral lentiginous melanoma is a rare melanoma subtype that disproportionately afflicts people of color. Acral lentiginous melanomas have a worse prognosis than other melanomas subtypes, which has been attributed to aggressive biological behavior, more advanced stage at presentation and possible disparities in access to healthcare. OBJECTIVES: Using comprehensive patient data and long-term follow-up information in a well-characterized cohort, to examine how patient, tumor, and clinical management variables impact overall and melanoma-specific survival...
April 22, 2017: British Journal of Dermatology
Y Yasukochi, M Kido-Nakahara, T Nakahara, R Kuroki, T Koga, T Mashino, Y Kurihara, M Furue
Atopic eczema (AE) has a high prevalence worldwide, imposing a tremendous burden on patients in terms of the cost and time and the psychological trauma. The Harmonizing Outcome Measures for Eczema (HOME) members achieved a consensus that outcome domains for AE trials should include clinical signs, symptoms, long-term control of flares and quality of life. The Patient-Oriented Eczema Measure (POEM) is a self-assessed, repeatable measurement tool, so patients can monitor their own eczema severity without visiting a hospital...
April 21, 2017: British Journal of Dermatology
C Hurabielle, F Sicre de Fontbrune, H Moins-Teisserenc, M Robin, M Jachiet, T Coman, C Cassius, F Chasset, A de Masson, D Michonneau, M Bagot, A Bergeron, G Socié, R Peffault de Latour, J-D Bouaziz
Chronic graft-versus-host disease (cGVHD) is frequent and severe after allogeneic hematopoietic stem cell transplantation (AHSCT), with unmet therapeutic needs.(1) A recent retrospective study has shown the potential efficacy of ruxolitinib, a selective Janus Kinase (JAK) 1/2 inhibitor, for the treatment of acute (n=54) and chronic GVHD (n=41) with a 81.5% and 85.4% overall response rate for acute and chronic GVHD respectively.(3) There are no specific studies evaluating the efficacy of ruxolitinib in sclerodermatous skin cGVHD, a rare and difficult-to-treat form of cGVHD...
April 19, 2017: British Journal of Dermatology
J Tiao, R Feng, E M Berger, J F Brandsema, C C Coughlin, N Khan, E A Kichula, M A Lerman, S Lvovich, P J McMahon, L G Rider, A I Rubin, L V Scalzi, D M Smith, A J Taxter, J R Treat, R P Williams, S W Yum, J Okawa, V P Werth
BACKGROUND: The Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI) and Cutaneous Assessment Tool-Binary Method (CAT-BM) have been shown to be reliable and valid outcome measures to assess cutaneous disease in adult dermatomyositis (DM) and juvenile DM (JDM), respectively. OBJECTIVE: This study compared the CDASI and CAT-BM for use by pediatric dermatologists, pediatric rheumatologists, and pediatric neurologists in patients with JDM. METHODS: Five pediatric dermatologists, five pediatric rheumatologists, and five pediatric neurologists each evaluated 14 patients with JDM using the CDASI, CAT-BM, and skin Physician Global Assessment (PGA) scales...
April 19, 2017: British Journal of Dermatology
M Sanlorenzo, I Vujic, V De Giorgi, C Tomasini, T Deboli, P Quaglino, M T Fierro, P Broganelli
Dermatoscopy is a non-invasive technique that allows a rapid and magnified in-vivo observation of the skin (1-3) . Manual dermatoscopy uses optical systems that work by modifying the cutaneous air-tissue optical interference (1) . Videodermatoscopy, on the other hand, is supported by digital systems allowing an image acquisition at higher magnification. This article is protected by copyright. All rights reserved.
April 19, 2017: British Journal of Dermatology
L Rocha, S W Menzies, S Lo, M Avramidis, R Khoury, L Jackett, P Guitera
BACKGROUND: Electrical impedance spectroscopy (EIS) is a non-invasive diagnostic technique that measures tissue impedance. OBJECTIVES: This prospective study, conducted at 2 centres in Australia, aimed to evaluate the effect of adding an EIS measurement at baseline to suspicious melanocytic lesions undergoing routine short-term sequential digital dermoscopy imaging (SDDI) METHODS: Patients presented with suspicious melanocytic lesions that were eligible for short-term SDDI (with no clear feature of melanoma on dermoscopy)...
April 19, 2017: British Journal of Dermatology
O Zehou, J-J Raynaud, C Le Roux-Villet, M Alexandre, G Airinei, F Pascal, M Heller, N Lièvre, L Laroche, F Caux, R Benamouzig, C Prost-Squarcioni
BACKGROUND: Oesophageal involvement of mucous membrane pemphigoid (MMP) has not yet been thoroughly described. OBJECTIVES: This study was undertaken to systematically characterise the endoscopic lesions of a series of patients with oesophageal symptoms seen in a referral centre for autoimmune bullous diseases. METHODS: Clinical, endoscopic and immunological findings of consecutively referred MMP patients with oesophageal involvement, systemic and endoscopic treatments and follow-up, are described...
April 18, 2017: British Journal of Dermatology
S Cheok, F Yee, J Y S Ma, R Leow, M S L Ho, Y W Yew, Y K Tay, S A Rebello, N Luo, M J A Koh
Atopic dermatitis (AD) is a common, chronic, pruritic skin condition that is known to negatively impact the quality of life (QOL) of patients(1,2) . Due to its increasing prevalence, AD can impose a substantial economic burden on a country's healthcare system.(3) A study in 2002 found a prevalence of 20.8% of AD in Singapore schoolchildren aged between 7 and 12 years(4) . This article is protected by copyright. All rights reserved.
April 17, 2017: British Journal of Dermatology
B C Y Chan, F Al-Niaimi, R Mallipeddi
Mohs micrographic surgery (MMS) is generally considered a safe and effective method of treating certain types of skin cancers, with low reported rates of surgical site infections.(1,2) Practices relating to infection control vary considerably amongst surgeons. Furthermore, emerging evidence suggests clean surgical techniques do not increase infection rates compared to sterile surgical techniques. We sought to establish the current infection control practices amongst surgeons practising MMS in the U.K. This article is protected by copyright...
April 13, 2017: British Journal of Dermatology
S Chen, X Kong, X Wei, Y Sun, D Yin, Q Zhang, L Du, J Man, L Mao, H Li, Y Tu, Y Yang
Ichthyosis vulgaris (IV, OMIM #146700) is a common semidominant disorder of keratinization, which is characterized by the xerosis, scaling, keratosis pilaris, palmar and plantar hyperlinearity, and a strong association with atopic disorders.(1) This article is protected by copyright. All rights reserved.
April 13, 2017: British Journal of Dermatology
P Starokadomskyy, L Sifuentes-Dominguez, T Gemelli, A R Zinn, M T Dossi, C Mellado, P Bertrand, A Borzutzky, E Burstein
X-linked reticulate pigmentary disorder (XLPDR, MIM 301220) is a rare syndrome first recognized by Partington(1) . The cardinal manifestations of the disorder are diffuse reticulate hyperpigmentation, hypohidrosis, and unique facial features, as well as recurrent pneumonias and sterile inflammation in various organs(1-9) . The syndrome is exceedingly rare and only 20 patients have been reported worldwide. Recently, we identified that the disorder is associated with a recurrent intronic mutation in POLA1, the gene encoding the catalytic subunit of DNA Polymerase-α(9) ...
April 13, 2017: British Journal of Dermatology
J Zhang, M Li, Z Yao
Reticulate pigmentary disorders are a group of disorders characterized by hyperpigmented and/or hypopigmented macules with varying sizes and amounts of pigment. Some of the disorders are heritable, such as Dowling-Degos disease, dyschromatosis universalis hereditaria, dyschromatosis symmetrica hereditaria and reticulate acropigmentation of Kitamura. Although, each condition possesses unique phenotypic characteristics and the prognosis for each is somewhat different, these disorders are highly overlapped and difficult to differentiate in the clinical setting...
April 13, 2017: British Journal of Dermatology
S Brown, J Ahmed, S Zwolinski, P Brennan, N Rajan
Desmocollin and desmoglein proteins are important in intercellular adhesion in both the skin and the heart.(1) Heterozygous mutations in desmocollin 2 (DSC2)(2) and desmoglein 2 (DSG2)(3) can both result in desmosomal dysfunction in cardiomyocytes, leading to development of fibro-fatty tissue, termed arrythmogenic right ventricular cardiomyopathy (ARVC). Heterozygous truncating mutations in desmoglein 1 (DSG1), an intervening gene, can present as a striate palmoplantar keratoderma, whilst homozygous DSG1 mutations can cause severe dermatitis, allergies and metabolic wasting...
April 13, 2017: British Journal of Dermatology
N Arase, K Tanimura, H Jin, T Yamaoka, M Kishibe, M Nishioka, E Kiyohara, M Tani, S Matsuoka, K Ohmura, K Takasugi, T Yamamoto, H Murota, H Arase, I Katayama
Chronic skin ulcers in the lower legs, feet, toes, and digits are sometimes idiopathic and intractable, and occasionally cause limb gangrene. Although there are many conditions that can cause chronic limb ulcers, including primary or secondary vascular diseases, the reasons why specific patients develop chronic skin ulcers have still remained unclear.(1) Antiphospholipid syndrome (APS) is an acquired coagulation disorder occurring as vascular thrombosis or pregnancy complications. This article is protected by copyright...
April 12, 2017: British Journal of Dermatology
L M Boyden, B G Craiglow, R H Hu, J Zhou, J Browning, L Eichenfield, Y L Lim, M Luu, L M Randolph, M Ginarte, L Fachal, L Rodriguez-Pazos, A Vega, D Kramer, G Yosipovitch, H Vahidnezhad, L Youssefian, J Uitto, R P Lifton, A S Paller, L M Milstone, K A Choate
The ichthyoses are rare skin disorders linked by the common finding of scale and concomitant barrier function abnormalities. Recently, mutations in PNPLA1 which encodes patatin-like phopholipase domain containing 1, and plays a role in the formation of the epidermal lipid barrier, have been identified as rare cause of non-syndromic ARCI(1-6) . This article is protected by copyright. All rights reserved.
April 12, 2017: British Journal of Dermatology
J E Lommerts, A A Meesters, L Komen, M W Bekkenk, M A de Rie, R M Luiten, A Wolkerstorfer
BACKGROUND: Autologous non-cultured cell suspension transplantation is an effective treatment for repigmentation in segmental vitiligo and piebaldism. Full surface laser ablation is frequently used to prepare the recipient site before cell suspension transplantation, even though optimal laser settings and ablation depth are unknown. OBJECTIVES: To assess the efficacy and safety of less invasive recipient site preparations. METHODS: In a randomised, observer-blinded, controlled trial we compared different recipient site preparations before cell suspension transplantation in segmental vitiligo and piebaldism...
April 12, 2017: British Journal of Dermatology
L Michel, P Reygagne, P Benech, F Jean-Louis, S Scalvino, S Ly Ka So, Z Hamidou, S Bianovici, J Pouch, B Ducos, M Bonnet, A Bensussan, A Patatian, E Lati, J Wdzieczak-Bakala, J-C Choulot, E Loing, M Hocquaux
BACKGROUND: Male androgenetic alopecia (AGA) is the most common form of hair loss in men and is characterized by a distinct pattern of progressive hair loss starting from the frontal area and the vertex of the scalp. Although several genetic risk loci have been identified, relevant genes for AGA remain to be defined. OBJECTIVES: Herein, molecular biomarkers associated with premature AGA were identified through gene expression analysis using cDNA generated from scalp vertex biopsies of hairless/bald men with premature AGA and healthy volunteers...
April 12, 2017: British Journal of Dermatology
C Fouques, M Dorez, F Le Duff, N Cardot-Leccia, A Chevallier, J P Lacour, P Bahadoran, A Bongain
vulvar intraepithelial neoplasia (VIN), a subtype of in situ squamous cell carcinoma (SCC), is a common problem particularly among women in their 40s. Two main variants exist: VIN of usual type (uVIN) occurs in young women, and is associated with HPV infection. VIN of differentiated type (dVIN) occurs in post-menopausal women, and is associated with lichen sclerosus. This article is protected by copyright. All rights reserved.
April 12, 2017: British Journal of Dermatology
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