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British Journal of Dermatology

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https://www.readbyqxmd.com/read/30239981/clinical-dermoscopic-and-reflectance-confocal-microscopy-characterization-of-facial-basal-cell-carcinomas-presenting-as-small-white-lesions-on-sun-damaged-skin
#1
LETTER
K Liopyris, C Navarrete-Dechent, O Yélamos, M A Marchetti, H Rabinovitz, A A Marghoob
Basal cell carcinoma (BCC) can present with a spectrum of clinical and dermoscopic morphologies, making their detection challenging; if left untreated can lead to significant cosmetic and/or functional morbidity. Dermoscopy and reflectance confocal microscopy (RCM) have been shown to aid in the diagnosis of BCC. Herein, we highlight the clinical, dermoscopic, and RCM characteristics of an under-appreciated morphology of BCC presenting as inconspicuous, white facial lesions that can easily go unnoticed or mistaken for fibrous papules or other benign lesions...
September 21, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30238444/a-randomized-trial-of-early-endovenous-ablation-in-venous-ulceration-a-critical-appraisal
#2
K T Weiß, F Zeman, S Schreml
Manjit S. Gohel et al. (N Engl J Med 2018; 378: 2105-2114) aimed to compare early endovenous ablation vs. deferred endovenous ablation of superficial venous reflux regarding time to healing of venous leg ulcers, rate of healing at 24 weeks, recurrence rate, ulcer-free time, and health-related quality of life. SETTING AND DESIGN: This multicentre, parallel-group (ratio 1:1), randomized controlled trial was conducted in a vascular surgery department setting at 20 participating centres across the United Kingdom...
September 20, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30230522/subtype-specific-inherited-predisposition-to-pemphigus-in-chinese-population
#3
S Zhang, X Zhou, X Zhou, Y Zhang, Y Deng, F Liao, M Yang, X Xia, Y Zhou, D Yin, P Ojaswi, Q Hou, L Wang, D Zhang, D Xia, Y Deng, L Ding, H Liu, W Yan, M Li, W Ma, J J Ma, Q Yu, B Liu, L Yang, W Zhang, Y Shu, H Xu, W Li
BACKGROUND: Pemphigus is a group of rare life-threatening cutaneous autoimmune diseases, presenting mainly as two subtypes including pemphigus vulgaris (PV) and pemphigus foliaceus (PF). Inherited predispositions to pemphigus have long been speculated but remains poorly understood. OBJECTIVE: To identify common and specific non-genetic and genetic factors associated with pemphigus and its subtypes in Chinese population. METHODS: Genome-wide association study was performed in 496 unrelated pemphigus patients (365 PV and 104 PF) and 1105 non-pemphigus controls...
September 19, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30229872/risk-of-first-time-and-recurrent-depression-in-patients-with-psoriasis-a-population-based-cohort-study
#4
A Egeberg, J P Thyssen, J J Wu, L Skov
BACKGROUND: Psoriasis impairs quality of life, but it is unknown whether psoriasis is also an independent risk factor for depression. OBJECTIVES: To evaluate incidence and risk of new and recurrent depression in patients with psoriasis. METHODS: We used individual-level linkage of Danish administrative registers. Patients with psoriasis aged ≥18 years between January 1st , 1997 and December 31st , 2016 were matched 1:1 with non-psoriasis individuals...
September 19, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30222854/valaciclovir-a-culprit-drug-for-dress-not-to-be-neglected-three-cases
#5
LETTER
S Ingen-Housz-Oro, C Bernier, G Gener, F Fichel, A Barbaud, B Lebrun-Vignes, H Assier
Valaciclovir is widely used for the treatment and prevention of Herpesvirus infections, especially in hematological diseases and solid organ transplantation1,2 , and has a very good benefit-to-risk ratio.3 Thus, its involvement in cases of cutaneous reaction may be neglected, especially if high-risk drugs are used concomitantly. We describe three cases of drug reactions with eosinophilia and systemic symptoms (DRESS) with proven causality by valaciclovir, illustrating this risk. This article is protected by copyright...
September 17, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30218575/precision-and-reproducibility-of-automated-computer-guided-pasi-measurements-in-comparison-to-trained-physicians
#6
C Fink, C Alt, L Uhlmann, C Klose, A Enk, H A Haenssle
BACKGROUND: The Psoriasis Area and Severity Index (PASI) represents the gold standard for psoriasis severity assessments but is limited by its subjectivity and low intra- and inter-rater consistency. OBJECTIVE: To investigate the precision and reproducibility of automated, computer-guided PASI measurements (ACPMs) in comparison to three trained physicians. METHODS: Comparative observational study assessing ACPMs attained by automated total body imaging (ATBI) and computerized digital image analysis in a cohort of 120 patients affected by plaque psoriasis of various severities...
September 15, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30216419/the-utility-of-optical-coherence-tomography-for-diagnosis-of-basal-cell-carcinoma-a-quantitative-review
#7
REVIEW
N Reddy, B T Nguyen
BACKGROUND: Optical coherence tomography (OCT) is a non-invasive near-infrared light imaging technology that can be utilized to diagnose basal cell carcinomas (BCCs) based on specific morphologic features. OBJECTIVES: To conduct a quantitative review using tumor level data from published studies to assess i) in-vivo diagnostic accuracy of different OCT systems; ii) correlation between OCT features and histopathological diagnosis; and iii) factors that impact accuracy of tumor depth estimation...
September 14, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30216412/sensitive-and-specific-assay-for-the-serological-diagnosis-of-anti-laminin-332-mucous-membrane-pemphigoid
#8
S Goletz, C Probst, L Komorowski, W Schlumberger, K Fechner, N van Beek, M M Holtsche, A Recke, K B Yancey, T Hashimoto, F Antonicelli, G Di Zenzo, D Zillikens, W Stöcker, E Schmidt
BACKGROUND: Anti-laminin 332 mucous membrane pemphigoid (MMP) is an autoimmune subepidermal blistering disease with predominant mucosal involvement and autoantibodies against laminin 332. Malignancies have been associated with this disease but however, no standardized detection system for anti-laminin 332 serum antibodies is widely available. OBJECTIVE: Development of a sensitive and specific assay for the detection of anti-laminin 332 antibodies. METHODS: An indirect immunofluorescence (IF) assay using recombinant laminin 332 was developed and probed with a large number of anti-laminin 332 MMP patients sera (n=93) as well as sera from patients with anti-laminin 332-negative MMP (n=153), bullous pemphigoid (n=20), pemphigus vulgaris (n=20), non-inflammatory dermatoses (n=22), and healthy blood donors (n=100)...
September 14, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30216411/cancer-is-not-a-risk-factor-for-bullous-pemphigoid-a-ten-year-population-based-cohort-study
#9
C T Chen, H Y Hu, Y T Chang, C P Li, C Y Wu
BACKGROUND: Bullous pemphigoid (BP) is the most common autoimmune bullous disease. Whether there is an increased risk for subsequent BP among cancer patients is still unclear. OBJECTIVE: We evaluated the risk for subsequent BP in cancer patients. METHODS: This nationwide population-based cohort study was based on data obtained from the Taiwan National Health Insurance Database between 2000 and 2011. A total of 36,838 cancer patients and 147,352 age-, sex- and index date-matched controls were recruited...
September 14, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30216406/management-of-congenital-ichthyoses-european-guidelines-of-care-part-one
#10
J Mazereeuw-Hautier, A Vahlquist, H Traupe, A Bygum, C Amaro, M Aldwin, A Audouze, C Bodemer, E Bourrat, A Diociaiuti, M Dolenc-Voljc, I Dreyfus, M El Hachem, J Fischer, A Ganemo, C Gouveia, R Gruber, S Hadj-Rabia, D Hohl, N Jonca, K Ezzedine, D Maier, R Malhotra, M Rodriguez, H Ott, D G Paige, A Pietrzak, F Poot, M Schmuth, J C Sitek, P Steijlen, G Wehr, M Moreen, E A O'Toole, V Oji, A Hernandez-Martin
These guidelines for the management of congenital ichthyoses have been developed by a multidisciplinary group of European experts following a systematic review of the current literature, an expert conference held in Toulouse in 2016, and a consensus on the discussions. They summarize evidence and expert-based recommendations and intend to help clinicians with the management of these rare and often complex diseases. These guidelines comprise two sections. This is Part one, covering topical therapies, systemic therapies, psychosocial management, communicating the diagnosis and genetic counselling...
September 14, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30216405/infrared-spectroscopy-as-a-novel-tool-to-diagnose-onychomycosis
#11
S De Bruyne, R Speeckaert, J Boelens, M-P Hayette, M Speeckaert, J Delanghe
BACKGROUND: The determination of causative organisms of onychomycosis is still not optimal. There remains a need for a cheap, fast and easy-to-perform diagnostic tool with highly distinctive capacities. OBJECTIVES: To determine whether ATR-FTIR spectroscopy can detect and differentiate causative agents in a culture based, ex vivo nail and in vivo nail model. METHODS: A methodological study was conducted. Both the ex vivo nail model and in vivo pilot study were carried out in an academic university hospital...
September 14, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30216404/factors-influencing-pain-and-efficacy-of-topical-photodynamic-therapy-a-retrospective-study
#12
LETTER
E Lydon, R Dawe, S Ibbotson
Photodynamic therapy (PDT) is widely used to treat superficial non-melanoma skin cancers and dysplasia. Pain may be experienced during irradiation, with one study showing pain intervention was required in 44% of PDT treatments. Other retrospective studies indicated that large treatment areas on head and neck sites, actinic keratoses and strong protoporphyrin IX fluorescence may be predictors of more severe PDT-induced pain, but data were not conclusive. This article is protected by copyright. All rights reserved...
September 14, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30207606/reference-method-for-digital-surface-measurement-of-target-lesions-in-vitiligo-a-comparative-analysis
#13
N van Geel, D Vandendriessche, E Vandersichel, S De Schepper, L Grine, L Mertens, V Vandaele, F Spoelders, M Bekkenk, A Wolkerstorfer, C A Prinsen, R Speeckaert
BACKGROUND: Objective measurement of target lesions in vitiligo is important for clinical practice and trials, yet no a preferred tool has been defined. Reported digital tools have shortcomings related to feasibility aspects and often lack information on validity, reliability and responsiveness. Moreover, studies are not yet based on UV photography. OBJECTIVES: To assess the reliability, validity and feasibility of two functions in ImageJ for measurement of target lesions, based on three different types of images including UV pictures...
September 12, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30207594/diagnostic-accuracy-of-content-based-dermatoscopic-image-retrieval-with-deep-classification-features
#14
P Tschandl, G Argenziano, M Razmara, J Yap
BACKGROUND: Automated classification of medical images through neural networks can reach high accuracy rates but lack interpretability. OBJECTIVES: To compare the diagnostic accuracy obtained by using content based image retrieval (CBIR) to retrieve visually similar dermatoscopic images with corresponding disease labels against predictions made by a neural network. METHODS: A neural network was trained to predict disease classes on dermatoscopic images from three retrospectively collected image datasets containing 888, 2750 and 16691 images respectively...
September 12, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30207589/variation-in-daily-ultraviolet-light-exposure-and-sun-protection-behaviours-of-melanoma-survivors-an-observational-single-arm-pilot-study-with-a-wearable-sensor
#15
LETTER
S Xu, T K Stump, J Jain, N Alshurafa, J K Robinson
Melanoma survivors are at risk to develop another melanoma and the same patterns of sun exposure that caused the initial melanoma contribute to the risk for a second melanoma.1 Despite awareness of the risk of developing another melanoma and the benefit of sun protection in modifying that risk,2 melanoma survivors often engage in unprotected episodes of sun exposure resulting in sunburn.3 While melanoma survivors initially decrease sun exposure following diagnosis, these changes are not maintained.4 This proof-of-concept study paired a wearable UV sensor with a self-report survey to explore sun protection behaviours of melanoma survivors This article is protected by copyright...
September 12, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30207587/gm-csf-as-a-therapeutic-target-in-psoriasis-randomised-controlled-investigation-using-namilumab-a-specific-human-anti-gm-csf-monoclonal-antibody
#16
K A Papp, M Gooderham, R Jenkins, R Vender, J C Szepietowski, T Wagner, B Hunt, B Souberbielle
BACKGROUND: The relevance of granulocyte-macrophage colony-stimulating factor (GM-CSF) in the management of psoriasis has not been studied previously. GM-CSF is important in the initiation and maintenance of chronic inflammatory processes. OBJECTIVE: To investigate the clinical use of GM-CSF neutralisation by evaluating the efficacy and safety of namilumab (AMG203), a monoclonal antibody GM-CSF inhibitor, in patients with moderate-to-severe plaque psoriasis. METHODS: A phase 2, multicentre, randomised, double-blind, placebo-controlled, parallel-group, dose-finding, proof-of-concept study (NEPTUNE) was conducted...
September 12, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30199574/recurrence-rate-of-cutaneous-squamous-cell-carcinoma-of-the-head-and-neck-after-mohs-micrographic-surgery-versus-standard-excision-a-retrospective-cohort-study
#17
C B van Lee, B M Roorda, M Wakkee, Q Voorham, A L Mooyaart, H C de Vijlder, T Nijsten, R R Van den Bos
BACKGROUND: Recurrent cutaneous squamous cell carcinoma (cSCC) has been associated with an increased risk of local functional and aesthetic comorbidity, metastasis and mortality. OBJECTIVE: To compare the risk of recurrence between Mohs micrographic surgery (MMS) and standard excision (SE) for cSCC of the head and neck. METHODS: Retrospective cohort study of all patients with a cSCC treated with MMS or SE at the Department of Dermatology in a secondary or tertiary care hospital in the Netherlands between 2003 and 2012...
September 10, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30194758/image-gallery-hairy-cell-leukaemia-presenting-with-sweet-syndrome
#18
P R Shah, G Scott, L A Beck
A 57-year-old man presented with a 1-month history of fevers, dermatitis and pancytopenia in the setting of a 14-lb weight loss, fatigue, night sweats and arthralgia. Skin examination revealed multiple erythematous papules on the (a) trunk and (b) extremities. Erythrocyte sedimentation rate and C-reactive protein were elevated (104 mm h-1 and 14.8 mg L-1 , respectively). This article is protected by copyright. All rights reserved.
September 8, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30192389/photodynamic-inactivation-of-bacteria-to-decolonize-methicillin-resistant-staphylococcus-aureus-mrsa-from-human-skin
#19
M Schreiner, W Bäumler, D Eckl, A Späth, B König, A Eichner
BACKGROUND: To prevent infections that arises from the skin surface it is necessary to decolonize human skin prior to any proposed treatment or surgical intervention. Photodynamic inactivation of bacteria (PIB) uses cationic photosensitizers that attach to the surface of bacteria, generate reactive oxygen species upon light irradiation and thereby kill bacteria via oxidative mechanisms. OBJECTIVES: To evaluate the potential and the safety of PIB for decolonization of bacteria from skin...
September 7, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30192377/cost-savings-of-adalimumab-in-hidradenitis-suppurativa-a-retrospective-analysis-of-a-real-world-cohort
#20
M Argyropoulou, T Kanni, M Kyprianou, N Melachroinopoulos, E J Giamarellos-Bourboulis
BACKGROUND: The introduction of adalimumab (ADA) in the management of hidradenitis suppurativa (HS) generates the question of the cost-efficacy of treatment. This was explored in a real-world cohort. METHODS: Patients with Hurley II and III stages under at least one-year of follow-up with at least three visits per year from September 2003 to December 2016 were analyzed. Patient-visits were divided into visits under treatment with agents blocking tumour necrosis factor (anti-TNFs) or other therapies...
September 7, 2018: British Journal of Dermatology
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