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British Journal of Dermatology

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https://www.readbyqxmd.com/read/28815560/comparison-of-indirubin-concentrations-in-indigo-naturalis-ointment-for-psoriasis-treatment-a-randomized-double-blind-dosage-controlled-trial
#1
Y K Lin, L C See, Y H Huang, C C Chi, R C Y Hui
BACKGROUND: Indigo naturalis and its refined formulation, Lindioil, are effective in treating psoriatic symptoms topically. Indirubin is the active ingredient in indigo naturalis. OBJECTIVES: To determine the efficacy and safety of different concentrations of indirubin in Lindioil ointment for treating psoriasis. METHODS: In this randomized, double-blind trial, adult patients presenting with chronic plaque psoriasis for >1 year and with <20% of the body surface area (BSA) affected were randomized to apply Lindioil ointment containing 200 μg/g, 100 μg/g, 50 μg/g, or 10 μg/g of indirubin twice daily for 8 weeks followed by an additional 12-week safety/extension period...
August 17, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28815554/severe-disruption-and-disorganization-of-dermal-collagen-fibrils-in-early-striae-gravidarum
#2
F Wang, K Calderone, T T Do, N R Smith, Y R Helfrich, T R B Johnson, S Kang, J J Voorhees, G J Fisher
BACKGROUND: Striae gravidarum (SG), or stretch marks of pregnancy, begin as erythematous streaks, and mature into hypopigmented atrophic bands. OBJECTIVES: To investigate molecular alterations that may promote atrophy of SG, we investigated dermal type I collagen fibrils, which provide human skin with support. METHODS: We obtained skin samples of recently developed, erythematous abdominal SG from pregnant women. To examine the organization of collagen fibrils, second-harmonic generation imaging was performed using multiphoton microscopy...
August 17, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28815553/osteoporosis-in-erythropoietic-protoporphyria-patients
#3
M Biewenga, R H S Matawlie, E C H Friesema, H Koole-Lesuis, M Langeveld, J H P Wilson, J G Langendonk
BACKGROUND: Erythropoietic protoporphyria is a rare metabolic disease with painful photosensitivity due to protoporphyrin IX accumulation, resulting in lifelong light avoidance behaviour. OBJECTIVES: The aim of this study was to evaluate bone mineral density and known osteoporosis risk factors in erythropoietic protoporphyria patients. METHODS: In this cross-sectional study all erythropoietic protoporphyria patients attending the Erasmus MC outpatient clinic that had undergone bone mineral density measurements were included...
August 17, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28815549/effect-of-long-term-treatment-with-tnf%C3%AE-inhibitors-on-single-dose-uv-induced-changes-in-human-skin
#4
LETTER
H J Kim, J L Langenhan, E S Robinson Es, E Privette, J C Achtman, R A Mitrani, M Zeidi, M R Sharma, R Feng, J L Nevas, C Calianno, J Okawa, L Taylor, L Pappas-Taffer, V P Werth
Tumor necrosis factor alpha (TNFα) is induced by ultraviolet (UV) light and important in photoinflammation.(1) Although TNFα inhibitors are commonly used for various inflammatory disorders like psoriasis, sometimes in combination with phototherapy, the effect of long-term TNFα inhibitor treatment with UV exposure on skin is unclear. This study was to see if chronic TNFα inhibition affects epidermal responses to UV, inflammatory infiltrate, and collagen composition in vivo. This article is protected by copyright...
August 17, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28804871/first-evaluation-of-the-behavioral-addiction-indoor-tanning-screener-baits-in-a-nationwide-representative-sample
#5
K Diehl, T Görig, E W Breitbart, R Greinert, J J Hillhouse, J L Stapleton, S Schneider
BACKGROUND: Evidence suggests that indoor tanning (IT) may have addictive properties. However, many instruments for measuring IT addiction show poor validity and reliability. Recently, a new instrument, the Behavioral Addiction Indoor Tanning Screener (BAITS), has been developed. OBJECTIVES: Our aim was to test validity and reliability of the BAITS by using a multi-method approach. METHODS: We used data of the first wave of the National Cancer Aid Monitoring on Sunbed Use (NCAM), which includes a cognitive pretest (08/2015) and a Germany-wide representative survey (10-12/2015)...
August 14, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28804873/re-frontal-fibrosing-alopecia-severity-index-ffasi-a-call-for-a-more-inclusive-and-globally-relevant-severity-index-for-frontal-fibrosing-alopecia-reply-from-the-authors
#6
LETTER
S Holmes, M Harries
No abstract text is available yet for this article.
August 13, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28799643/sebocytes-contribute-to-skin-inflammation-by-promoting-the-differentiation-of-th17-cells
#7
M Mattii, M Lovászi, N Garzorz, A Atenhan, M Quaranta, F Lauffer, A Konstantinow, M Küpper, C C Zouboulis, L Kemeny, K Eyerich, C B Schmidt-Weber, D Törőcsik, S Eyerich
BACKGROUND: The main function of sebocytes is considered to be the lipid production for moisturizing the skin. However, it became recently apparent that sebocytes release chemokines and cytokines and respond to pro-inflammatory stimuli as well as presence of bacteria. OBJECTIVES: To analyze the functional communication between human sebocytes and T cells. METHODS: Immunofluorescence stainings for CD4 and IL-17 were performed on acne sections and healthy skin...
August 11, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28796891/solar-urticaria-developing-in-patients-with-erythropoietic-protoporphyria-a-clue-to-the-pathogenesis-of-solar-urticaria
#8
LETTER
A Tewari, A Fityan, H Fassihi, R Sarkany
We describe three cases of solar urticaria (SU) developing in patients with a diagnosis of Erythropoietic Protoporphyria (EPP). We suggest that this may imply that the endothelium may be the location of a chromophore in SU. Patient 1 was a 42-year-old female. She had EPP characterised lifelong by three day long bouts of burning pain and swelling on the backs of hands and face induced by 10 minutes of exposure to spring or summer sun, and an increased red cell free protoporphyrin IX concentration (36micromol/L (normal range <0...
August 10, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28796887/sirolimus-effects-on-kasabach-merritt-phenomenon-coagulopathy
#9
LETTER
O Boccara, E Puzenat, S Proust, T Leblanc, D Lasne, S Hadj-Rabia, C Bodemer
Kasabach-Merritt phenomenon (KMP) is a very rare life-threatening condition that combines a vascular tumor belonging to the kaposiform hemangioendothelioma (KHE) spectrum lesions, and thrombocytopenia.(1,2) Thrombocytopenia results from platelet trapping within the tumor. Platelet activation leads to various degrees of decreased fibrinogen and elevated D-dimer levels. This coagulopathy is frequently protracted after thrombocytopenia resolution. Several treatments have been proposed with variable efficiency...
August 10, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28796885/photodynamic-therapy-is-more-effective-than-imiquimod-for-actinic-keratosis-in-organ-transplant-recipients-a-randomized-intra-individual-controlled-trial
#10
K Togsverd-Bo, C Halldin, C Sandberg, H Gonzalez, A M Wennberg, S S Sørensen, H C O Wulf, M Haedersdal
BACKGROUND: Actinic keratoses (AKs) in solid organ transplant recipients (OTRs) are difficult-to-treat pre-malignancies and comparison of topical therapies is therefore warranted. OBJECTIVES: In an intra-individual study to compare efficacy and safety of field treatment with methyl aminolevulinate photodynamic therapy (MAL-PDT) and imiquimod (IMIQ) for AKs in OTRs. MATERIALS AND METHODS: OTRs (n=35) with 572 AKs (grade I-III) in two similar areas in the face, scalp, dorsal hands or forearms were included...
August 10, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28796884/acquired-anhidrosis-associated-with-systemic-sarcoidosis-quantification-of-nerve-fibers-around-eccrine-glands-by-confocal-microscopy
#11
LETTER
M Nishida, T Namiki, Y Sone, T Hashimoto, S Tokoro, T Hanafusa, H Yokozeki
Neurological disorders can cause hypohidrosis and/or anhidrosis by disturbing either the central or the peripheral nervous systems.(1-3) Although a syringotropic variant of cutaneous sarcoidosis causes dysfunction of sweating, systemic sarcoidosis rarely causes hypohidrosis or anhidrosis.(4,5) Here we present a novel case of an acquired anhidrosis in a patient with systemic sarcoidosis. Furthermore, we developed a novel methodology to quantify nerve fibers around eccrine glands using confocal microscopy and found that nerve fibers around eccrine glands in anhidrotic areas are significantly decreased compared to hidrotic areas...
August 10, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28796883/are-vitiligo-treatments-cost-effective-a-systematic-review
#12
LETTER
E McManus, T Sach, N J Levell
Vitiligo is characterised by well demarcated, cutaneous, macular depigmentation, with worldwide prevalence estimated to be between 0.2-1.8% [1]. Vitiligo treatments aim to encourage re-pigmentation and include topical corticosteroids, calcineurin inhibitors and NB-UVB phototherapy. Camouflage can also be prescribed to help mask the appearance of vitiligo, although this is frequently only prescribed for the face. This article is protected by copyright. All rights reserved.
August 10, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28796881/the-immune-reconstitution-of-the-skin-following-sex-mismatched-allogeneic-hematopoietic-stem-cell-transplant-a-prospective-case-series-utilizing-fluorescent-in-situ-hybridization-and-immunohistochemistry
#13
LETTER
C L Stewart, C M Cornejo, K A Wanat, I Sander, S Samimi, S Prouty, J Seykora, P Zhang, M Rosenbach, E J Kim, R G Micheletti
Graft versus host disease (GVHD) is a common, morbid, and potentially fatal complication of allogeneic hematopoietic stem cell transplantation (aHSCT).(1-3) The exact timing of the arrival of donor-derived immune cells and their profile in the skin have not been well described in humans.(4-6) Fluorescent in situ hybridization (FISH) is a technique that has been used to distinguish host versus donor-derived immune cells in patients who have undergone sex-mismatched aHSCT.(7) This article is protected by copyright...
August 10, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28791687/skin-signs-of-primary-immunodeficiencies-how-to-find-the-genes-to-check
#14
REVIEW
M Ettinger, J Schreml, K Wirsching, M Berneburg, S Schreml
Primary immunodeficiencies (PIDs) are a heterogeneous group of rare diseases that result from defects in immune system development and/or function. The clinical manifestations of PIDs are highly variable, but most disorders involve at least an increased susceptibility to infection. Furthermore, cutaneous manifestations are very common in PIDs. As an easy accessible organ, skin canbecrucial for early diagnosis and treatment. This is relevant for preventing significant disease-associated morbidity and mortality...
August 9, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28782100/uk-national-audit-of-extracorporeal-photopheresis-in-ctcl
#15
LETTER
S Sanyal, F Child, A Alfred, T Callaghan, N Alband, S Whittaker, R Cowan, E Parry, S Robinson, M G S Dunnill, A Howles, A Arumainathan, R Azurdia, J Grant-Casey, R N Matin, D Gilson, C Howell, K El-Gheriani, P Taylor, J Scarisbrick
We performed a national audit of extracorporeal photopheresis (ECP) in cutaneous T-cell lymphoma (CTCL) to gather information on number of treatment cycles, treatment duration and reason for stopping. UK Consensus Guidelines and European ECP Guidelines recommend that ECP can be considered for first-line treatment for erythrodermic CTCL patients with blood involvement [1,2,3]. Publications have shown effectiveness of ECP in early-stage MF, stage IA-IIA [4,5] and ECP is listed as a systemic treatment option in refractory early-stage MF in the National Comprehensive Cancer Network Guidelines [6]...
August 7, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28771669/prognostic-importance-of-a-second-invasive-primary-melanoma-according-to-tumor-stage
#16
LETTER
D R Youlden, P D Baade, J F Aitken, A C Green, K Khosrotehrani
It is well known that a considerable proportion of the Caucasian population in many countries are diagnosed with multiple melanomas over time(1) . Despite this, most analyses of melanoma survival, including that of the American Joint Committee on Cancer (AJCC), consider only one tumor for every patient and disregard the potential effect of multiple melanomas on outcomes and this is reflected in the lack of specific management guidelines for patients with multiple melanomas beyond those dictated by the clinicopathological features of each tumour(2-4) ...
August 3, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28771668/safety-and-efficacy-of-topical-timolol-treatment-of-infantile-haemangioma-a-prospective-trial
#17
LETTER
J Borok, P Gangar, S Admani, J Proudfoot, S F Friedlander
Topical timolol therapy is considered a relatively "safer" alternative for the treatment of infantile haemangiomas (IH); however, sufficient supportive pharmacokinetic data does not exist. Most efficacy studies have not evaluated systemic absorption.(1-5) To our knowledge, this is the first prospective trial to assess the clinical response of proliferating IH to topical timolol maleate 0.5% gel-forming solution and to determine if systemic absorption occurred.Twenty-six subjects enrolled in this trial approved by the UCSD IRB...
August 3, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28771665/tnf-antagonist-induced-lupus-a-critically-appraised-topic
#18
REVIEW
S E Momen, B Kirkham, J N Barker, C H Smith
TNF antagonist induced lupus is diagnosed upon a temporal relationship of TNF antagonist therapy and the development of four of the 11 American college of rheumatology (ACR) diagnostic criteria for lupus. We critically appraise the literature on TNF antagonist induced lupus, focusing on the diagnostic criteria, dermatological manifestations, management and outcome. Eighty cases of TNF antagonist induced lupus that met the ACR criteria were included and analysed. Infliximab was the most commonly reported agent (58...
August 3, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28771657/time-pasi-and-dlqi-of-psoriasis-patients-who-drop-out-of-clinical-trials-on-etanercept-due-to-lack-of-efficacy-a-pooled-analysis-from-ten-clinical-trials
#19
A Nast, M Dilleen, W Liyanage, L Aikman, P Szczypa, C Dressler
BACKGROUND: Patient-reported outcomes in psoriasis studies are assessed at specific study time points. If a treatment has not become effective by a certain time point, it may increase the likelihood of patients being dissatisfied and leaving a clinical study. OBJECTIVES: Generate evidence concerning the number of patients dropping out of etanercept trials over time including PASI and DLQI data. METHODS: Data from psoriasis patients in ten trials with etanercept were pooled...
August 3, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28762482/medication-adherence-among-psoriasis-patients-on-traditional-systemic-and-biologic-treatment
#20
LETTER
R Hambly, A Kelly, E Gilhooley, E Nic Dhonncha, A Murad, R Hughes, A Lally, B Kirby
The World Health Organisation defines medication adherence as "the extent to which a patients' behaviour in taking their medication corresponds to agreed recommendations by their healthcare provider". Up to 25% of patients, across all medical conditions, do not take their medication. Patients with poor adherence have worse outcomes and higher health care costs. This article is protected by copyright. All rights reserved.
August 1, 2017: British Journal of Dermatology
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