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British Journal of Dermatology

C C Zouboulis, T Tzellos, A Kyrgidis, G B E Jemec, F G Bechara, E J Giamarellos-Bourboulis, J R Ingram, T Kanni, I Karagiannidis, A Martorell, Ł Matusiak, A Pinter, E P Prens, D Presser, S Schneider-Burrus, E von Stebut, J C Szepietowski, H H van der Zee, S M Wilden, R Sabat
BACKGROUND: A validated tool for the dynamic severity assessment of hidradenitis suppurativa (HS) is lacking. The aim of this study was to develop and validate such a novel scoring system. METHODS: A Delphi voting procedure was conducted among the members of the European Hidradenitis Suppurativa Foundation (EHSF) to achieve consensus towards an initial HS Severity Score System (HS4). Strengths and weaknesses of HS4 were examined by a multicenter prospective study...
June 21, 2017: British Journal of Dermatology
M Le Moigne, J-P Fournier, S Bulteau, M Grall-Bronnec, A Khammari, C Victorri-Vigneau, B Dréno
The question of the association between isotretinoin and the development of psychiatric disorders has been debated for the past 20 years. Some authors have argued that similar psychiatric symptoms or disorders could also be induced by other systemic retinoids(1) . However, few reports have included a formal assessment of the causal link between systemic retinoids and psychiatric disorders. This article is protected by copyright. All rights reserved.
June 19, 2017: British Journal of Dermatology
A K Smit, L A Keogh, A J Newson, P N Butow, K Dunlop, R L Morton, J Kirk, D Espinoza, A E Cust
BACKGROUND: Receiving information about melanoma genomic risk might trigger conversations about skin cancer prevention and skin examinations. OBJECTIVES: To explore conversations prompted by receiving personalised genomic risk of melanoma with family, friends and health professionals. METHODS: We used a mixed-methods approach. Participants without a personal history and unselected for a family history of melanoma (n=103, aged 21-69, 53% women) completed questionnaires 3-months after receiving a personalised melanoma genomic risk assessment...
June 19, 2017: British Journal of Dermatology
A Helander, M Bradley, J Lapins
No abstract text is available yet for this article.
June 19, 2017: British Journal of Dermatology
J Agustí, R Bella-Navarro, A B García-García, E Bueno, R González-Sarmiento, L Navarro, B Sanchez-Sendra, A Revert, E Jordá, C Monteagudo
BACKGROUND: A variety of genodermatoses with multiple cutaneous tumors with germline genetic alterations such as Gorlin syndrome with PTCH1 gene mutations have been described. Other cutaneous syndromes have been associated with somatic gene mutations, such as FGFR3 in familial seborrhoeic keratosis. OBJECTIVE: We describe the clinical, dermoscopic, and histopathological features of multiple cutaneous lesions, mostly infundibulocystic basal cell carcinomas and pure reticulated acanthomas, present in a family affected by familial seborrhoeic keratosis...
June 18, 2017: British Journal of Dermatology
H Sonbol, S Duchatelet, S Miskinyte, B Bonsang, A Hovnanian, L Misery
PASH syndrome is a clinical entity associating pyoderma gangrenosum (PG), severe acne and hidradenitis suppurativa (HS)(1) . Absence of pyogenic sterile arthritis (PA) distinguishes PASH syndrome from PAPASH and PAPA syndromes which associate PA in combination with PG, severe acne with or without HS, respectively(2,3) . Mutations in PSTPIP1 (proline-serine-threonine-phosphatase interacting protein 1) gene were identified in patients with PAPA and PAPASH syndromes, although genetic heterogeneity was observed in PAPA syndrome(2,3) ...
June 18, 2017: British Journal of Dermatology
N R Adler, L V Graudins, A K Aung
We read with interest Teo et al.'s recently published article examining cutaneous adverse drug reactions (cADR) referred to an inpatient liaison dermatology service.(1) The authors assessed the number and types of cADR encountered and subsequent documentation.(1) The diagnosis and management of cADR has been recognised by NICE Guidelines on Drug Allergy as a high-priority area for quality improvement.(2) We commend Teo and colleagues(1) for examining an essential, yet often overlooked, component of health service quality...
June 18, 2017: British Journal of Dermatology
J Delaunay, A P Villani, P Guillem, A Tristan, A Boibieux, D Jullien
Rifampicin/Clindamycin (RC) combination is recommended as first line therapy in moderate to severe Hidradenitis Suppurativa (HS) by European S1 guidelines (1-3), notably because a large variety of microorganisms have been isolated from HS lesions: most represented bacteria appear to be Staphylococcus aureus, Coagulase negative staphylococci (CoNS) and anaerobic bacteria from normal skin flora. It has been hypothesized that these bacteria could play a central role in the initiation and maybe in the maintenance of HS lesions, possibly by being a source of antigens in a dysregulated immune response...
June 18, 2017: British Journal of Dermatology
C Olteanu, R Dodiuk-Gad, R Hashimoto, N Shear
We read with great interest, the review paper by Lee et al. on the long term complications of Stevens-Johnson syndrome and toxic epidermal necrolysis. We would like to congratulate the authors on this important and excellent overview. This review demonstrated that SJS/TEN has a severe, chronic phase with major physical morbidities. We wish to raise awareness to the major emotional complications among survivors; as was found in our study published in the British Journal of Dermatology by Dodiuk-Gad et al. This article is protected by copyright...
June 18, 2017: British Journal of Dermatology
C Dessinioti, C Antoniou, A J Stratigos
The deciphering of the hedgehog (Hh) signaling pathway implicated in the tumorigenesis of basal cell carcinoma (BCC), led to the development of targeted drug therapies, e.g. the hedgehog pathway inhibitors (HPI), vismodegib and sonidegib. In the skin, physiologic Hh signaling is activated in growing hair follicles, where it is required for proliferation of the epithelium of hair follicles during morphogenesis and for their postnatal growth. The effects of HPI treatment leading to the regression of BCC and the development of alopecia, underpin the central role of the Hh pathway in BCC formation as well as hair cycling...
June 18, 2017: British Journal of Dermatology
H Bhullar, A Saracino, J Douglass, G Varigos, K Nicholls, R Martyres
Mastocytosis is classified by the World-Health-Organisation (WHO)(1) as cutaneous-mastocytosis (CM) and systemic-mastocytosis (SM). CM is subdivided into maculopapular (MPCM), diffuse-CM and mastocytomas. SM is subdivided into indolent (ISM), with-an-associated-haematologic-neoplasm (SM-AHN)(2) , aggressive (ASM) and mast-cell-leukemia (MCL). This article is protected by copyright. All rights reserved.
June 16, 2017: British Journal of Dermatology
A M Drucker, A A Qureshi, T J B Dummer, L Parker, W-Q Li
BACKGROUND: Atopic dermatitis (AD) has been associated with cardiovascular risk factors and diseases, but epidemiologic studies to date have found conflicting results. OBJECTIVES: We aimed to determine the associations of AD with hypertension, type-2 diabetes (T2D), myocardial infarction (MI) and stroke. METHODS: We conducted a cross-sectional analysis of baseline data from the Canadian Partnership for Tomorrow Project which includes Canadian residents aged 30-74 living in British Columbia, Alberta, Ontario, Quebec and the Atlantic Provinces...
June 15, 2017: British Journal of Dermatology
W Alwan, M Lynch, J McFadden, I R White, P Banerjee
Psoriasis and allergic contact dermatitis (ACD) are common, chronic T-lymphocyte mediated conditions. Although psoriasis patients are commonly referred for patch testing, there are conflicting views on the relationship between contact allergy and psoriasis. Previous studies have suggested ACD is less common in psoriasis(1) and that psoriatics are more difficult to sensitize(1,2,3) . This article is protected by copyright. All rights reserved.
June 15, 2017: British Journal of Dermatology
S K Kim, C A Barker
Non-melanoma cutaneous squamous and basal cell carcinoma (NMSC) is common, and most patients present with early stage (T1/T2) NMSC, which has an excellent prognosis. However, a minority of NMSC patients present with an advanced stage (T3/T4) primary tumor, which may be surgically unresectable but potentially curable with radiation therapy (RT). Because advanced NMSC is rare, studies(1-5) examining the outcomes of RT for patients with T3/T4 tumors are limited. As the outcomes of RT in this patient cohort are unclear, this study was undertaken to examine survival in a large cohort of patients treated at our institution and to explore variables associated with survival outcomes...
June 15, 2017: British Journal of Dermatology
M F Holick
Whiteman, Olsen and Green noted the Felton study (1) was short term and limited by the number of biopsies. What this study demonstrated was that even for only 6 weeks of repeated exposures to sensible suberythemal doses of simulated solar ultraviolet radiation (UVR), there was a marked increase in the skin's defense mechanisms to overcome the damaging effects caused by the DNA absorbing the UVR. Whiteman et al. acknowledge that within 24 hours after the final exposure the levels of photo damage were significantly lower...
June 12, 2017: British Journal of Dermatology
A Blauvelt, L K Ferris, P S Yamauchi, A Qureshi, C L Leonardi, K Farahi, S Fakharzadeh, M-C Hsu, S Li, M Chevrier, K Smith, K Goyal, Y Chen, E J Muñoz-Elías, K Callis Duffin
BACKGROUND: Phase 3 studies showed some patients maintained response for ≥6 months post-ustekinumab discontinuation. OBJECTIVES: To assess clinical responses with extended ustekinumab maintenance dosing intervals. METHODS: Adults with moderate-to-severe plaque psoriasis received ustekinumab (45mg/90mg for weight ≤100 kg/>100 kg) at Week0, Week4, Week16 during open-label treatment. Patients achieving a Week 28 Physician's Global Assessment score of cleared/minimal (PGA=0/1) were randomized 1:4 to Group1 (approved every-12-weeks [q12wk] maintenance) or Group2 (q12-24wk response-based dosing determined by time-to-loss-of-PGA=0/1)...
June 10, 2017: British Journal of Dermatology
D C Whiteman, C M Olsen, A C Green
We read with interest the recent paper by Felton and colleagues (1) describing the effects of solar-simulated ultraviolet radiation (UVR) on cutaneous DNA damage and vitamin D production. However, we were disappointed by the accompanying editorial by Dr Holick (2) proclaiming that healthcare regulators (and by inference, doctors and the public) "could have their cake and eat it too". In particular, his assertion that "sensible sun exposure that does not cause burning" should raise "little concern" about skin cancer risk is at odds with the photodamage observed by Felton and colleagues in the epidermal cells of fair-skinned participants following repeated, low-level sun exposure...
June 10, 2017: British Journal of Dermatology
K A Papp, H Bachelez, A Blauvelt, K L Winthrop, R Romiti, M Ohtsuki, N Acharya, D K Braun, L Mallbris, F Zhao, W Xu, C D Walls, B Strober
BACKGROUND: Infections are associated with biologic therapies in psoriasis. OBJECTIVES: To summarise the incidence of infections in moderate-to-severe psoriasis patients treated with ixekizumab, an anti-interleukin (IL)-17A monoclonal antibody. METHODS: Infections are summarised from an integrated database of 7 controlled and uncontrolled ixekizumab psoriasis trials. Data are presented from placebo-controlled induction (Weeks 0-12; UNCOVER-1, -2, and -3) and maintenance periods (Weeks 12-60; UNCOVER-1 and -2) as well as all ixekizumab-exposed patients pooled from all 7 trials...
June 10, 2017: British Journal of Dermatology
D T Egu, E Walter, V Spindler, J Waschke
BACKGROUND: Pemphigus vulgaris (PV) is a skin blistering disease caused by autoantibodies targeting the desmosomal adhesion proteins desmoglein (Dsg) 3 and 1. The mechanisms underlying pemphigus skin blistering are not fully elucidated but p38MAPK activation is one of the signaling events necessary for full loss of cell cohesion. However, it is unclear whether ultrastructural hallmarks of desmosome morphology as observed in patients' lesions are mediated by p38MAPK signaling. OBJECTIVE: In this study, we tested the relevance of p38MAPK for blister formation and the ultrastructural changes induced by PV autoantibodies in human skin...
June 10, 2017: British Journal of Dermatology
W J Lee, Y J Kim, Y J Lee, C H Won, S E Chang, J H Choi, M W Lee
Vascular endothelial growth factor (VEGF) can stimulate angiogenesis and lymphangiogenesis, which are crucial processes in the growth and metastasis of tumour cells.(1,2) The immunohistochemical status of VEGF protein expression in tumour tissue of extranodal NK/T-cell lymphoma (ENKTL) has not yet been evaluated. Herein, we investigated VEGF protein expression, as well as its prognostic value in cutaneous ENKTL patients. This article is protected by copyright. All rights reserved.
June 9, 2017: British Journal of Dermatology
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