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British Journal of Dermatology

R Goorochurn, C Viennet, M Tissot, F Locatelli, C Granger, N Varin-Blank, P Humbert, C Le Roy
Upon ageing, chronic exposure to ultraviolet radiations and pollution induces benign hyper-pigmented lesions, such as Solar Lentigo maculae (SL) (1) . Well-defined histologically, SL is distinguishable from other hyper-pigmented diseases and can be classified relative to its evolution (2-4) . Differential gene-profiling analyses comparing SL and normal skin biopsies revealed that SL tissues are mainly composed of epidermal activated melanocytes as well as hypo-proliferating and hypo-differentiated keratinocytes with a background of chronic inflammation...
February 17, 2017: British Journal of Dermatology
A C Green, C M Olsen
Cutaneous squamous cell carcinoma (SCC) is a common cancer in white populations and its disease burden is often substantially underestimated. SCC occurs more often in men than women and increases dramatically with age; those affected often develop multiple primaries over time, which increases the burden. The main external cause is solar ultraviolet radiation (UVR), with immunosuppression being the other established risk factor, shown by the high SCC rates in organ transplant recipients. Sunbed use and certain genetic disorders and medical conditions are also associated with SCC, while associations with human papillomavirus infection and high bodyweight are not established...
February 16, 2017: British Journal of Dermatology
P Dani, N Patnaik, A Singh, A Jaiswal, B Agrawal, A A Kumar, S R Varkhande, A Sharma, U Vaish, P Ghosh, V K Sharma, P Sharma, G Verma, H K Kar, S Gupta, V T Natarajan, R S Gokhale, R Rani
BACKGROUND: Vitiligo is a multifactorial, autoimmune, depigmenting disorder of the skin where aberrant presentation of auto antigens may have a role to play. OBJECTIVES: To study the association of antigen processing genes, PSMB8 and PSMB9 with vitiligo. METHODS: 1320 vitiligo cases (1050 generalized and 270 localized) and 752 normal healthy controls were studied for PSMB9 exon 3 G/A SNP, PSMB8 exon 2 C/A SNP and PSMB8 Intron 6 G/T at 37360 site using PCR-RFLP...
February 16, 2017: British Journal of Dermatology
R Dybboe, J Bandier, L Skov, L Engstrand, J D Johansen
BACKGROUND: Dysbiosis is a hallmark of atopic dermatitis. The composition of skin microbiome communities and the causality of dysbiosis in eczema have not been well established. OBJECTIVE: To describe the skin microbiome profile in atopic dermatitis and address if there is a causal relationship between dysbiosis and atopic dermatitis. METHODS: The protocol is registered in PROSPERO (CRD42016035813). We searched PubMed, Embase, Scopus and ClinicalTrials...
February 16, 2017: British Journal of Dermatology
M Talamonti, M Galluzzo, J M van den Reek, E M de Jong, J L W Lambert, P Malagoli, L Bianchi, A Costanzo
BACKGROUND: Little is known about role of HLA-C*06 related to response to psoriasis treatments. OBJECTIVES: This study that involved four European centres aims to confirm the role of HLA-C*06 in a new large cohort of patients, as a pharmacogenetic marker of response to ustekinumab. METHODS: In this retrospective multicenter study we reviewed data of 255 psoriasis patients genotyped for HLA-C*06, which have started ustekinumab treatment between January 2014 and March 2015...
February 16, 2017: British Journal of Dermatology
S Ribero, C Costa, F Sidoti, S Osella-Abate, R Senetta, P Cassoni, M T Fierro, R Cavallo
Some viral proteins expressed by Human Polyomaviruses (HPyV) are known to be able to cause cancer. Besides Merkel-Cell-Polyoma-Virus (MCV), four new human polyomaviruses have been identified in the last years. In 2010, the Sixth and Seventh HPyV (HPyV6 and HPyV7) were discovered(2) . Similar to MCV, HPyV6 and HPyV7 seem to be constituents of the human skin microbiome. Co-infecting HPyVs may therefore act as a co-factor in the development of cancers, including those induced by other oncoviruses. Despite these observations, their role in cancer remains controversial...
February 16, 2017: British Journal of Dermatology
Z Qin, R M Balimunkwe, T Quan
BACKGROUND: Fragmentation of collagen fibrils, the major structure protein in skin, is a hallmark of dermal aging. Matrix metalloproteinases (MMPs) are largely responsible for fragmentation of collagen fibrils. However, the alteration of all known mammalian MMPs and the mechanism underlying altered expression of MMPs in chronologically aged human skin are less understood. OBJECTIVES: To quantify gene expression of all 23 known mammalian MMPs in sun-protected young and aged human skin in vivo, and investigate the potential mechanism underlying age-related alteration of multiple MMPs...
February 14, 2017: British Journal of Dermatology
C Santonja, A Santos-Briz, G Palmedo, H Kutzner, L Requena
BACKGROUND: Human parvovirus B19 (B19V) has been associated with a number of dermatologic and systemic conditions, including myocarditis and autoimmune syndromes. OBJECTIVES: To determine the frequency of B19V deoxyribonucleic acid (DNA) detection in a large dermatopathology practice, and to characterize the histopathologic patterns involved. METHODS: We selected for polymerase chain reaction (PCR) detection of B19V a total of 1,815 skin biopsies pertaining to entities allegedly related to Parvovirus B19, as well as cases suspected clinically of representing paraviral exanthemas...
February 14, 2017: British Journal of Dermatology
J Bagel, S Tyring, K C Rice, D H Collier, G Kricorian, J Chung, J Iles, B S Stolshek, A Kaliyaperumal, K A Papp
BACKGROUND: Some plaque psoriasis patients experience secondary failure of tumour necrosis factor inhibitor therapy. OBJECTIVES: To evaluate efficacy, safety, and patient-reported outcomes (PROs) with etanercept in patients with secondary adalimumab failure. METHODS: This phase 4, open-label, single-arm, estimation study (NCT01543204) enrolled patients on adalimumab who had achieved static physician global assessment (sPGA) score 0/1 (clear/almost clear)...
February 14, 2017: British Journal of Dermatology
F Gómez-García, J Ruano, M Aguilar-Luque, J Gay-Mimbrera, B Maestre-Lopez, J L Sanz-Cabanillas, P J Carmona-Fernández, M González-Padilla, A Vélez García-Nieto, B Isla-Tejera
BACKGROUND: The quality of systematic reviews (SRs) and meta-analyses about psoriasis, a chronic inflammatory skin disease that severely impairs quality of life and is associated with high costs, remains unknown. OBJECTIVES: To assess the methodological quality of SRs published on psoriasis. METHODS: After a comprehensive search in MEDLINE, EMBASE, and the Cochrane Database (PROSPERO:CDR4201604161), the quality was assessed by two raters using Assessment of Multiple Systematic Reviews (AMSTAR) tool...
February 13, 2017: British Journal of Dermatology
C Peeters, A Herman, M Baeck
A 25 years-old woman, with a history of personal atopic dermatitis, allergic asthma and hay fever, experienced a facial angioedema 5 minutes after consuming fresh donkey's milk for the first time (Fig. 1). She developed dyspnea and collapsed after a few minutes. The patient required administration of adrenaline and corticosteroids. During her childhood, her atopic dermatitis was treated with different topical treatments including donkey's milk based emollients. She never presented reactions to this topical treatment and she had no history of food allergy...
February 11, 2017: British Journal of Dermatology
C Mazaud, L Fardet
Low-dose (i.e., ≤30 mg/week) methotrexate is widely prescribed by dermatologists. However, there are few evidence-based data regarding the relative risk of and determinants for adverse events associated with this treatment. The aims of this review were to assess the relative risk of and the determinants for adverse events associated with low-dose methotrexate exposure. A systematic review was undertaken using the MEDLINE, EMBASE, and CENTRAL databases. Randomized controlled trials comparing low-dose methotrexate with placebo were eligible...
February 9, 2017: British Journal of Dermatology
I Vázquez-Osorio, N Chmel, E Rodríguez-Díaz, P Gonzalvo-Rodríguez, R Happle, E Bueno, C Has, A Torrelo
Ectodermal dysplasia-skin fragility syndrome (ED-SFS) is an autosomal recessive genodermatosis characterized by skin fragility, chronic cheilitis, palmoplantar keratoderma, abnormal hair growth and nail dystrophy. ED-SFS is caused by mutations in the PKP1 gene encoding pakophilin-1 (PKP1), which results in desmosomal abnormality and poor intercellular cohesion between the epidermal cells. We report a case of a 2-year-old girl with unilateral superficial erosions, plantar keratoderma and nail dystrophy, all showing a Blaschko-linear arrangement...
February 9, 2017: British Journal of Dermatology
I M Skoie, I Dalen, T Ternowitz, G Jonsson, I Kvivik, K Norheim, R Omdal
BACKGROUND: Fatigue is associated with various chronic inflammatory diseases, but few studies have focused on its occurrence in psoriasis. OBJECTIVES: To describe fatigue prevalence and degree among patients with chronic plaque psoriasis compared with age- and gender-matched healthy subjects, and to examine how fatigue is influenced by essential clinical and demographic factors. METHODS: In 84 patients and 84 healthy subjects, fatigue severity was assessed using three different generic fatigue instruments: the fatigue Visual Analogue Scale (fVAS), the Fatigue Severity Scale (FSS), and the Short Form 36 (SF-36) vitality scale...
February 9, 2017: British Journal of Dermatology
J C Su, R Dailey, M Zallmann, E Leins, L Taresch, S Donath, S S Heah, A J Lowe
INTRODUCTION: Despite limited evidence, woollen clothing has traditionally been considered to be an irritant that should be avoided by individuals with atopic dermatitis (AD). Wool fibres come in a range of diameters, and have beneficial thermodynamic and moisture transport properties. This study examines the effects of superfine merino wool on symptoms in participants with mild-moderate AD. METHODS: The trial was a 12-week randomized assessor-blinded cross-over prospective cohort study of 39 patients aged 4 weeks to 3 years with mild-moderate AD, comparing superfine merino wool ensembles with standard cotton clothing chosen by parents...
February 9, 2017: British Journal of Dermatology
L Gao, R Yin, H Wang, W Guo, W Song, J S Nelson, W Tan, G Wang
Port wine stain (PWS) is a congenital vascular malformation of human skin involving the superficial vascular plexus,(1-4) but the molecular pathogenesis of these lesions remains incompletely understood.(5-8) We herein performed a transmission electron microscopy (TEM) study to determine the main pathological characteristics and ultrastructure of various cell types, including endothelial cells (ECs), pericytes, fibroblasts and keratinocytes, in hypertrophic and nodular PWS. The study was approved by the Investigational Review Board at the Xijing Hospital, Xi'an, China...
February 9, 2017: British Journal of Dermatology
R Hughes, E Knudsen, S Kirthi, G Kelly, A M Tobin, C M Sweeney, G B E Jemec, B Kirby
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with a known association with obesity [1]. Evidence of an association between metabolic syndrome and HS has been reported [2]. The Framingham Risk Score (FRS) [3] is a gender-specific algorithm used to estimate an individual's 10-year cardiovascular risk. Despite limitations of its use, it remains one of the most widely used risk assessment tools. Patients scoring less than 10% are considered to be at low risk, those between 10% and 20% are at moderate risk and those scoring 20% or more are considered to be at high risk...
February 6, 2017: British Journal of Dermatology
C Y Ng, Y-H Huang, C-F Chu, T-C Wu, S-H Liu
Evidence on whether psoriasis patients have a higher risk for staphylococcal colonization than healthy controls remained controversial. To synthesize the current literature, we performed a systematic review on prevalence and relative risk (RR) of S. aureus colonization in psoriasis patients. We modified the QUADAS-2 instrument to assess the reporting quality of individual studies and applied random-effects models in meta-analysis. Overall, we identified 21 eligible studies, of which 15 enrolled one or more comparison groups...
February 3, 2017: British Journal of Dermatology
S M Gilbert, A Gidley Baird, S Glazer, J A Barden, A Glazer, L C Teh, J King
BACKGROUND: Expression of P2X7 , an ATP gated calcium channel, increases cancer cell proliferation and invasiveness. A variant of P2X7 (termed nfP2X7 ), in which a normally hidden epitope (E200) is exposed for antibody binding, is observed in a variety of different cancers. OBJECTIVES: To investigate the safety, tolerability and pharmacokinetics and assess indicative efficacy of a novel antibody ointment as a therapeutic for BCC. METHODS: An open label, Phase 1 clinical trial was undertaken at 3 dermatology clinics to evaluate the safety and tolerability of topical administration of an ointment containing 10% sheep polyclonal anti-nfP2X7 antibodies (BIL010t) to primary BCC lesions twice daily for 28 days...
February 2, 2017: British Journal of Dermatology
E Galimova, E Khusnutdinova, R Rätsep, T Traks, K Kingo, V Escott-Price, S Kõks
BACKGROUND: Interleukin (IL)-10 family cytokines IL-10, IL-19, IL-20, and IL-24 have been implicated in autoimmune diseases and we have previously reported that genetic variants in IL10 gene cluster were associated with psoriasis. OBJECTIVE: To analyze the relationship of genetic polymorphisms in the IL10 gene cluster with psoriasis. This study also explores whether there are gene-gene interactions among these genetic polymorphisms. METHODS: A total of 377 patients with psoriasis and 403 matched healthy controls were enrolled to carry out a case-control study for 48 SNPs of IL10 gene cluster...
February 2, 2017: British Journal of Dermatology
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