Advances in BPA-induced Oxidative Stress and Related Effects and Mechanisms in liver，1991-2017.

Bisphenol A (BPA) is an environmental endocrine disruptor widely spreading in life. Its characteristics, including small does, long incubation period, and frequent contact, make it easy to enter human body through drinking water, food, air and other pathways, leading to tumors, infertility, and liver damage. The present review summarizes the underlying mechanism of oxidative stress and its related effects induced by BPA in liver. The progress of research into the mechanism of oxidative stress induced by BPA is summarized, including mitochondrial dysfunction, lipid peroxidation and inflammation reaction, liver dyslipidemia, apoptosis, cell death mechanism. In the future, it is necessary to elucidate the mechanisms and timing of BPA-induced molecular mechanisms against oxidative stress and epigenetic disruption, clarify the effects on different exposures to different genders and growth stages, the toxic effects of BPA surrogates, the toxic effects of BPA metabolites and BPA combined with other pollutants into the environment endocrine disrupting effect, to clarify the environmental and human health effects of BPA, to provide technical reference for the development of practical control measures.