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Journal Article
Review
Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas.
Frontiers of Medicine 2018 April 13
Viral infections cause at least 10%-15% of all human carcinomas. Over the last century, the elucidation of viral oncogenic roles in many cancer types has provided fundamental knowledge on carcinogenetic mechanisms and established a basis for the early intervention of virus-related cancers. Meanwhile, rapidly evolving genomeediting techniques targeting viral DNA/RNA have emerged as novel therapeutic strategies for treating virusrelated carcinogenesis and have begun showing promising results. This review discusses the recent advances of genome-editing tools for treating tumorigenic viruses and their corresponding cancers, the challenges that must be overcome before clinically applying such genome-editing technologies, and more importantly, the potential solutions to these challenges.
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