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Journal of Personalized Medicine

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https://www.readbyqxmd.com/read/30400625/impact-of-precision-medicine-on-drug-repositioning-and-pricing-a-too-small-to-thrive-crisis
#1
REVIEW
Venkataswarup Tiriveedhi
The pricing of targeted medicines continues to be a major area of contention in healthcare economics. This issue is further complicated by redefining the role of molecular testing in precision medicine. Currently, whilst pricing of clinical laboratory diagnostics is cost-based, drug pricing is value-based. The pricing for molecular testing is under pressure to change the traditional business model, for it has a critical subsidiary role in determining the final value of targeted medicines. The market size for drugs is reduced by molecular testing when patients with the same disease are stratified based on their genetics, it is critical to determine the value of this new enhanced drug specificity to realize its full pricing potential...
November 5, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/30400379/patient-and-provider-perspectives-on-a-decision-aid-for-familial-hypercholesterolemia
#2
Medhat Farwati, Ashok Kumbamu, David C Kochan, Iftikhar J Kullo
Familial Hypercholesterolemia (FH) is an inherited disorder associated with increased cardiovascular risk that requires patients to make multiple impactful decisions regarding the management of their condition. Patient decision aids (PDAs) can facilitate shared decision-making (SDM) and enable patients to make choices that are concordant with their goals and values. To inform the development of a PDA for patients with FH, we employed a qualitative inductive approach and focus group discussions with patients, physicians, and genetic counselors...
November 4, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/30282955/current-and-emerging-reconstituted-hdl-apoa-i-and-hdl-apoe-approaches-to-treat-atherosclerosis
#3
REVIEW
Eftaxia-Konstantina Valanti, Katerina Dalakoura-Karagkouni, Despina Sanoudou
Atherosclerosis affects millions of people worldwide. However, the wide variety of limitations in the current therapeutic options leaves much to be desired in future lipid-lowering therapies. For example, although statins, which are the first-line treatment for coronary heart disease (CHD), reduce the risk of cardiovascular events in a large percentage of patients, they lead to optimal levels of low density lipoprotein-cholesterol (LDL-C) in only about one-third of patients. A new promising research direction against atherosclerosis aims to improve lipoprotein metabolism...
October 3, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/30275411/40-years-of-percutaneous-coronary-intervention-history-and-future-directions
#4
REVIEW
John Canfield, Hana Totary-Jain
The field of interventional cardiology has evolved significantly since the first percutaneous transluminal coronary angioplasty was performed 40 years ago. This evolution began with a balloon catheter mounted on a fixed wire and has progressed into bare-metal stents (BMS), first-generation drug-eluting stents (DES), second- and third-generation biodegradable polymer-based DES, and culminates with the advent of bioabsorbable stents, which are currently under development. Each step in technological advancement has improved outcomes, while new persisting challenges arise, caused by the stent scaffolds, the polymers employed, and the non-selective cytostatic and cytotoxic drugs eluted from the stents...
October 1, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/30275409/the-implementation-process-for-pharmacogenomic-testing-for-cancer-targeted-therapies
#5
Ann Chen Wu, Kathleen M Mazor, Rachel Ceccarelli, Stephanie Loomer, Christine Y Lu
Recent advances in genomic medicine have led to the availability of genomic tests that have the potential to improve population health, yet the process for obtaining these tests and getting them reimbursed by insurers has not been described. The objective of this study was to describe the process of ordering pharmacogenomic tests by interviewing providers, patients, and laboratories about cancer-related pharmacogenomic tests. We interviewed patients who were prescribed, providers who prescribed medications that should be guided by pharmacogenomic testing, and individuals from diagnostic laboratories...
October 1, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/30248964/personalised-medicine-the-odyssey-from-hope-to-practice
#6
REVIEW
Sophie Visvikis-Siest, Vesna Gorenjak, Maria G Stathopoulou
In this endeavour, inspired by the Odyssey, we aim to embark with the reader on a journey on a ship from Troy to Ithaca, coursing through the history of the momentous events and achievements that paved the way for personalised medicine. We will set sail amidst important genetic discoveries, beginning with the discovery of the first human genome, and voyage through the projects that contributed to the progress of pharmacogenomic studies. Concurrently, we will propose methods to overcome the obstacles that are slowing the potential full implementation of accumulated knowledge into everyday practice...
September 21, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/30227640/the-role-of-next-generation-sequencing-in-precision-medicine-a-review-of-outcomes-in-oncology
#7
REVIEW
Margaret Morash, Hannah Mitchell, Himisha Beltran, Olivier Elemento, Jyotishman Pathak
Precision medicine seeks to use genomic data to help provide the right treatment to the right patient at the right time. Next-generation sequencing technology allows for the rapid and accurate sequencing of many genes at once. This technology is becoming more common in oncology, though the clinical benefit of incorporating it into precision medicine strategies remains under significant debate. In this manuscript, we discuss the early findings of the impact of next-generation sequencing on cancer patient outcomes...
September 17, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/30223463/individualized-transcriptional-resolution-of-complicated-malaria-in-a-colombian-study
#8
Mónica L Rojas-Peña, Meixue Duan, Dalia Arafat, Lina Rengifo, Socrates Herrera, Myriam Arévalo-Herrera, Greg Gibson
To evaluate whether recovery from complicated malaria follows a common trajectory in terms of immunological mechanism or, rather, is highly individualized for each patient, we performed longitudinal gene expression profiling of whole blood. RNA sequencing (RNAseq) was performed on blood samples obtained from eight patients on four consecutive days between hospital admission and discharge. Six patients were infected with Plasmodium falciparum , and two with Plasmodium vivax; one patient was a pregnant woman infected with P...
September 14, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/30189667/a-metabolomics-approach-to-pharmacotherapy-personalization
#9
REVIEW
Elena E Balashova, Dmitry L Maslov, Petr G Lokhov
The optimization of drug therapy according to the personal characteristics of patients is a perspective direction in modern medicine. One of the possible ways to achieve such personalization is through the application of "omics" technologies, including current, promising metabolomics methods. This review demonstrates that the analysis of pre-dose metabolite biofluid profiles allows clinicians to predict the effectiveness of a selected drug treatment for a given individual. In the review, it is also shown that the monitoring of post-dose metabolite profiles could allow clinicians to evaluate drug efficiency, the reaction of the host to the treatment, and the outcome of the therapy...
September 5, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/30142941/design-of-a-controlled-trial-of-cascade-screening-for-hypercholesterolemia-the-cash-study
#10
Iftikhar J Kullo, Kent R Bailey
To inform guidelines for screening family members of patients with familial hypercholesterolemia (FH), we designed a clinical trial to compare the yield of cascade screening in FH patients with and without an identifiable pathogenic variant. Participants with hypercholesterolemia (Low-density lipoprotein cholesterol (LDL-C) > 155 mg/dL) underwent sequencing of LDLR , APOB , and PCSK9 and genotyping of six single nucleotide polymorphisms associated with LDL-C followed by calculation of a polygenic score for LDL-C...
August 23, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/30082654/gene-metabolite-interaction-in-the-one-carbon-metabolism-pathway-predictors-of-colorectal-cancer-in-multi-ethnic-families
#11
S Pamela K Shiao, James Grayson, Chong Ho Yu
For personalized healthcare, the purpose of this study was to examine the key genes and metabolites in the one-carbon metabolism (OCM) pathway and their interactions as predictors of colorectal cancer (CRC) in multi-ethnic families. In this proof-of-concept study, we included a total of 30 participants, 15 CRC cases and 15 matched family/friends representing major ethnic groups in southern California. Analytics based on supervised machine learning were applied, with the target variable being specified as cancer, including the ensemble method and generalized regression (GR) prediction...
August 6, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/30046027/early-outcome-data-assessing-utility-of-a-post-test-genomic-counseling-framework-for-the-scalable-delivery-of-precision-health
#12
Amy C Sturm, Tara Schmidlen, Laura Scheinfeldt, Shelly Hovick, Joseph P McElroy, Amanda E Toland, J Scott Roberts, Kevin Sweet
Information on patients' preferences is essential to guide the development of more efficient genomic counseling service delivery models. We examined patient preferences in the context of use of a post-test genomic counseling framework on patients ( n = 44) with chronic disease receiving online test reports for eight different diseases and one drug-response result. We also explored patients' disease risk awareness, recall of test report information, and confidence in knowing what to do with their test results...
July 25, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/30042363/physician-reported-benefits-and-barriers-to-clinical-implementation-of-genomic-medicine-a-multi-site-ignite-network-survey
#13
Aniwaa Owusu Obeng, Kezhen Fei, Kenneth D Levy, Amanda R Elsey, Toni I Pollin, Andrea H Ramirez, Kristin W Weitzel, Carol R Horowitz
Genetic medicine is one of the key components of personalized medicine, but adoption in clinical practice is still limited. To understand potential barriers and provider attitudes, we surveyed 285 physicians from five Implementing GeNomics In pracTicE (IGNITE) sites about their perceptions as to the clinical utility of genetic data as well as their preparedness to integrate it into practice. These responses were also analyzed in comparison to the type of study occurring at the physicians' institution (pharmacogenetics versus disease genetics)...
July 24, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/29973520/preface-to-special-issue-on-cytochrome-p450-variation-in-pharmacogenomics
#14
EDITORIAL
Allan E Rettie, Stephen B Liggett
No abstract text is available yet for this article.
July 4, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/29958440/warfarin-the-end-or-the-end-of-one-size-fits-all-therapy
#15
REVIEW
Munir Pirmohamed
Oral anticoagulants are required for both treatment and prophylaxis in many different diseases. Clinicians and patients now have a choice of oral anticoagulants, including the vitamin K antagonists (of which warfarin is the most widely used and is used as the exemplar in this paper), and direct oral anticoagulants (DOACs: dabigatran, apixaban, rivaroxaban, and edoxaban). This paper explores the recent advances and controversies in oral anticoagulation. While some commentators may favour a complete switchover to DOACs, this paper argues that warfarin still has a place in therapy, and a stratified approach that enables the correct choice of both drug and dose would improve both patient outcomes and affordability...
June 28, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/29949895/willingness-to-participate-in-a-national-precision-medicine-cohort-attitudes-of-chronic-kidney-disease-patients-at-a-cleveland-public-hospital
#16
Jessica N Cooke Bailey, Dana C Crawford, Aaron Goldenberg, Anne Slaven, Julie Pencak, Marleen Schachere, William S Bush, John R Sedor, John F O'Toole
Multiple ongoing, government-funded national efforts longitudinally collect health data and biospecimens for precision medicine research with ascertainment strategies increasingly emphasizing underrepresented groups in biomedical research. We surveyed chronic kidney disease patients from an academic, public integrated tertiary care system in Cleveland, Ohio, to examine local attitudes toward participation in large-scale government-funded studies. Responses ( n = 103) indicate the majority (71%) would participate in a hypothetical national precision medicine cohort and were willing to send biospecimens to a national repository and share de-identified data, but <50% of respondents were willing to install a phone app to track personal data...
June 26, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/29786664/enable-2017-the-first-european-phd-and-post-doc-symposium-session-3-in-vitro-to-in-vivo-modeling-life-in-3d
#17
Gianmarco Di Mauro, Ambra Dondi, Giovanni Giangreco, Alexander Hogrebe, Elja Louer, Elisa Magistrati, Meeli Mullari, Gemma Turon, Wouter Verdurmen, Helena Xicoy Cortada, Sanja Zivanovic
The EUROPEAN ACADEMY FOR BIOMEDICAL SCIENCE (ENABLE) is an initiative funded by the European Union Horizon 2020 program involving four renowned European research institutes (Institute for Research in Biomedicine-IRB Barcelona, Spain; Radboud Institute for Molecular Life Sciences-RIMLS, the Netherlands; Novo Nordisk Foundation Center for Protein Research-NNF CPR, Denmark; European School of Molecular Medicine-SEMM, Italy) and an innovative science communication agency (Scienseed). With the aim to promote biomedical science of excellence in Europe, ENABLE organizes an annual three-day international event...
May 22, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/29772692/insurance-coverage-policies-for-pharmacogenomic-and-multi-gene-testing-for-cancer
#18
Christine Y Lu, Stephanie Loomer, Rachel Ceccarelli, Kathleen M Mazor, James Sabin, Ellen Wright Clayton, Geoffrey S Ginsburg, Ann Chen Wu
Insurance coverage policies are a major determinant of patient access to genomic tests. The objective of this study was to examine differences in coverage policies for guideline-recommended pharmacogenomic tests that inform cancer treatment. We analyzed coverage policies from eight Medicare contractors and 10 private payers for 23 biomarkers (e.g., HER2 and EGFR ) and multi-gene tests. We extracted policy coverage and criteria, prior authorization requirements, and an evidence basis for coverage. We reviewed professional society guidelines and their recommendations for use of pharmacogenomic tests...
May 16, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/29735935/correction-antoniou-m-et-al-fixed-and-adaptive-parallel-subgroup-specific-design-for-survival-outcomes-power-and-sample-size-j-pers-med-2017-7-19
#19
Miranta Antoniou, Andrea L Jorgensen, Ruwanthi Kolamunnage-Dona
No abstract text is available yet for this article.
May 7, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/29735910/correction-antoniou-m-et-al-biomarker-guided-non-adaptive-trial-designs-in-phase-ii-and-phase-iii-a-methodological-review-j-pers-med-2017-7-1
#20
Miranta Antoniou, Ruwanthi Kolamunnage-Dona, Andrea L Jorgensen
No abstract text is available yet for this article.
May 7, 2018: Journal of Personalized Medicine
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