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Journal of Personalized Medicine

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https://www.readbyqxmd.com/read/28657610/the-clinical-and-economic-impact-of-inaccurate-egfr-mutation-tests-in-the-treatment-of-metastatic-non-small-cell-lung-cancer
#1
Mindy M Cheng, John F Palma, Sidney Scudder, Nick Poulios, Oliver Liesenfeld
Advances in personalized medicine are supported by companion diagnostic molecular tests. Testing accuracy is critical for selecting patients for optimal therapy and reducing treatment-related toxicity. We assessed the clinical and economic impact of inaccurate test results between laboratory developed tests (LDTs) and a US Food and Drug Administration (FDA)-approved test for detection of epidermal growth factor receptor (EGFR) mutations. Using a hypothetical US cohort of newly diagnosed metastatic non-small cell lung cancer (NSCLC) patients and EURTAC (erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer) clinical trial data, we developed a decision analytic model to estimate the probability of misclassification with LDTs compared to a FDA-approved test...
June 28, 2017: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/28587070/development-and-initial-assessment-of-a-patient-education-video-about-pharmacogenetics
#2
Rachel Mills, Megan Ensinger, Nancy Callanan, Susanne B Haga
As few patient-friendly resources about pharmacogenetics are currently available, we aimed to create and assess a patient educational video on pharmacogenetic testing. A primary literature and resources review was conducted to inform the content and the format of the video. The educational video was then created using a commercially available animation program and pilot tested in focus groups of the general public and by an online survey of pharmacists. Emerging themes from the focus groups and survey indicate a desire for appropriate risk contextualization and specific examples when pharmacogenetic testing may be beneficial...
May 25, 2017: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/28538708/accuracy-in-wrist-worn-sensor-based-measurements-of-heart-rate-and-energy-expenditure-in-a-diverse-cohort
#3
Anna Shcherbina, C Mikael Mattsson, Daryl Waggott, Heidi Salisbury, Jeffrey W Christle, Trevor Hastie, Matthew T Wheeler, Euan A Ashley
The ability to measure physical activity through wrist-worn devices provides an opportunity for cardiovascular medicine. However, the accuracy of commercial devices is largely unknown. The aim of this work is to assess the accuracy of seven commercially available wrist-worn devices in estimating heart rate (HR) and energy expenditure (EE) and to propose a wearable sensor evaluation framework. We evaluated the Apple Watch, Basis Peak, Fitbit Surge, Microsoft Band, Mio Alpha 2, PulseOn, and Samsung Gear S2. Participants wore devices while being simultaneously assessed with continuous telemetry and indirect calorimetry while sitting, walking, running, and cycling...
May 24, 2017: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/28134833/methods-for-the-in-vitro-characterization-of-nanomedicines-biological-component-interaction
#4
REVIEW
Cristina Fornaguera, Conxita Solans
The design of colloidal nanosystems intended for biomedical applications, specifically in the field of personalized medicine, has increased notably in the last years. Consequently, a variety of characterization techniques devoted to studying nanomedicine interactions with proteins and cells have been developed, since a deep characterization of nanosystems is required before starting preclinical and clinical studies. In this context, this review aims to summarize the main techniques used to assess the interaction of nanomedicines with biological systems, highlighting their advantages and disadvantages...
January 27, 2017: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/28125057/biomarker-guided-non-adaptive-trial-designs-in-phase-ii-and-phase-iii-a-methodological-review
#5
REVIEW
Miranta Antoniou, Ruwanthi Kolamunnage-Dona, Andrea L Jorgensen
Biomarker-guided treatment is a rapidly developing area of medicine, where treatment choice is personalised according to one or more of an individual's biomarker measurements. A number of biomarker-guided trial designs have been proposed in the past decade, including both adaptive and non-adaptive trial designs which test the effectiveness of a biomarker-guided approach to treatment with the aim of improving patient health. A better understanding of them is needed as challenges occur both in terms of trial design and analysis...
January 25, 2017: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/27827859/precision-health-economics-and-outcomes-research-to-support-precision-medicine-big-data-meets-patient-heterogeneity-on-the-road-to-value
#6
Yixi Chen, Gregory F Guzauskas, Chengming Gu, Bruce C M Wang, Wesley E Furnback, Guotong Xie, Peng Dong, Louis P Garrison
The "big data" era represents an exciting opportunity to utilize powerful new sources of information to reduce clinical and health economic uncertainty on an individual patient level. In turn, health economic outcomes research (HEOR) practices will need to evolve to accommodate individual patient-level HEOR analyses. We propose the concept of "precision HEOR", which utilizes a combination of costs and outcomes derived from big data to inform healthcare decision-making that is tailored to highly specific patient clusters or individuals...
November 2, 2016: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/27801815/idicap-a-novel-tool-for-integrating-drug-intervention-based-on-cancer-panel
#7
Noelle Kosarek, Eric S Ho
Cancer is a heterogeneous disease afflicting millions of people of all ages and their families worldwide. Tremendous resources have been and continue to be devoted to the development of cancer treatments that target the unique mutation profiles of patients, namely targeted cancer therapy. However, the sheer volume of drugs coupled with cancer heterogeneity becomes a challenge for physicians to prescribe effective therapies targeting patients' unique genetic mutations. Developing a web service that allows clinicians as well as patients to identify effective drug therapies, both approved and experimental, would be helpful for both parties...
October 28, 2016: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/27657137/implementing-personalized-medicine-in-the-academic-health-center
#8
EDITORIAL
Scott T Weiss
Recently we at Partners Health Care had a series of articles in the Journal of Personalized Medicine describing how we are going about implementing Personalized Medicine in an academic health care system [1-10].[...].
September 21, 2016: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/27294961/implementation-of-electronic-consent-at-a-biobank-an-opportunity-for-precision-medicine-research
#9
Natalie T Boutin, Kathleen Mathieu, Alison G Hoffnagle, Nicole L Allen, Victor M Castro, Megan Morash, P Pearl O'Rourke, Elizabeth L Hohmann, Neil Herring, Lynn Bry, Susan A Slaugenhaupt, Elizabeth W Karlson, Scott T Weiss, Jordan W Smoller
The purpose of this study is to characterize the potential benefits and challenges of electronic informed consent (eIC) as a strategy for rapidly expanding the reach of large biobanks while reducing costs and potentially enhancing participant engagement. The Partners HealthCare Biobank (Partners Biobank) implemented eIC tools and processes to complement traditional recruitment strategies in June 2014. Since then, the Partners Biobank has rigorously collected and tracked a variety of metrics relating to this novel recruitment method...
June 9, 2016: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/27144585/personalized-medicine-in-the-u-s-and-germany-awareness-acceptance-use-and-preconditions-for-the-wide-implementation-into-the-medical-standard
#10
Kateryna Kichko, Paul Marschall, Steffen Flessa
The aim of our research was to collect comprehensive data about the public and physician awareness, acceptance and use of Personalized Medicine (PM), as well as their opinions on PM reimbursement and genetic privacy protection in the U.S. and Germany. In order to give a better overview, we compared our survey results with the results from other studies and discussed Personalized Medicine preconditions for its wide implementation into the medical standard. For the data collection, using the same methodology, we performed several surveys in Pennsylvania (U...
May 2, 2016: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/27136589/barriers-and-facilitators-to-adoption-of-genomic-services-for-colorectal-care-within-the-veterans-health-administration
#11
Nina R Sperber, Sara M Andrews, Corrine I Voils, Gregory L Green, Dawn Provenzale, Sara Knight
We examined facilitators and barriers to adoption of genomic services for colorectal care, one of the first genomic medicine applications, within the Veterans Health Administration to shed light on areas for practice change. We conducted semi-structured interviews with 58 clinicians to understand use of the following genomic services for colorectal care: family health history documentation, molecular and genetic testing, and genetic counseling. Data collection and analysis were informed by two conceptual frameworks, the Greenhalgh Diffusion of Innovation and Andersen Behavioral Model, to allow for concurrent examination of both access and innovation factors...
April 28, 2016: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/27023617/personal-genome-sequencing-in-ostensibly-healthy-individuals-and-the-peopleseq-consortium
#12
REVIEW
Michael D Linderman, Daiva E Nielsen, Robert C Green
Thousands of ostensibly healthy individuals have had their exome or genome sequenced, but a much smaller number of these individuals have received any personal genomic results from that sequencing. We term those projects in which ostensibly healthy participants can receive sequencing-derived genetic findings and may also have access to their genomic data as participatory predispositional personal genome sequencing (PPGS). Here we are focused on genome sequencing applied in a pre-symptomatic context and so define PPGS to exclude diagnostic genome sequencing intended to identify the molecular cause of suspected or diagnosed genetic disease...
March 25, 2016: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/26927187/infrastructure-for-personalized-medicine-at-partners-healthcare
#13
Scott T Weiss, Meini Sumbada Shin
Partners HealthCare Personalized Medicine (PPM) is a center within the Partners HealthCare system (founded by Massachusetts General Hospital and Brigham and Women's Hospital) whose mission is to utilize genetics and genomics to improve the care of patients in a cost effective manner. PPM consists of five interconnected components: (1) Laboratory for Molecular Medicine (LMM), a CLIA laboratory performing genetic testing for patients world-wide; (2) Translational Genomics Core (TGC), a core laboratory providing genomic platforms for Partners investigators; (3) Partners Biobank, a biobank of samples (DNA, plasma and serum) for 50,000 Consented Partners patients; (4) Biobank Portal, an IT infrastructure and viewer to bring together genotypes, samples, phenotypes (validated diagnoses, radiology, and clinical chemistry) from the electronic medical record to Partners investigators...
February 27, 2016: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/26927186/bioinformatics-workflow-for-clinical-whole-genome-sequencing-at-partners-healthcare-personalized-medicine
#14
Ellen A Tsai, Rimma Shakbatyan, Jason Evans, Peter Rossetti, Chet Graham, Himanshu Sharma, Chiao-Feng Lin, Matthew S Lebo
Effective implementation of precision medicine will be enhanced by a thorough understanding of each patient's genetic composition to better treat his or her presenting symptoms or mitigate the onset of disease. This ideally includes the sequence information of a complete genome for each individual. At Partners HealthCare Personalized Medicine, we have developed a clinical process for whole genome sequencing (WGS) with application in both healthy individuals and those with disease. In this manuscript, we will describe our bioinformatics strategy to efficiently process and deliver genomic data to geneticists for clinical interpretation...
February 27, 2016: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/26861400/serotonin-2a-receptor-snp-rs7330461-association-with-treatment-response-to-pomaglumetad-methionil-in-patients-with-schizophrenia
#15
Laura K Nisenbaum, AnnCatherine M Downing, Fangyi Zhao, Brian A Millen, Leanne Munsie, Bruce J Kinon, David H Adams, Juan Carlos Gomez, Michelle Ann Penny
This study aims to confirm the initial pharmacogenetic finding observed within the clinical proof-of-concept trial of an enhanced response to treatment with pomaglumetad methionil (LY2140023 monohydrate) in Caucasian schizophrenia patients homozygous for T/T at single nucleotide polymorphism rs7330461 in the serotonin (5-hydroxytryptamine) 2A receptor gene compared to A/A homozygous patients. The effect of the rs7330461 genotype on the response to pomaglumetad methionil treatment was assessed in three additional clinical trials and in an integrated analysis...
February 5, 2016: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/26927185/the-translational-genomics-core-at-partners-personalized-medicine-facilitating-the-transition-of-research-towards-personalized-medicine
#16
Ashley Blau, Alison Brown, Lisa Mahanta, Sami S Amr
The Translational Genomics Core (TGC) at Partners Personalized Medicine (PPM) serves as a fee-for-service core laboratory for Partners Healthcare researchers, providing access to technology platforms and analysis pipelines for genomic, transcriptomic, and epigenomic research projects. The interaction of the TGC with various components of PPM provides it with a unique infrastructure that allows for greater IT and bioinformatics opportunities, such as sample tracking and data analysis. The following article describes some of the unique opportunities available to an academic research core operating within PPM, such the ability to develop analysis pipelines with a dedicated bioinformatics team and maintain a flexible Laboratory Information Management System (LIMS) with the support of an internal IT team, as well as the operational challenges encountered to respond to emerging technologies, diverse investigator needs, and high staff turnover...
2016: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/26927184/the-biobank-portal-for-partners-personalized-medicine-a-query-tool-for-working-with-consented-biobank-samples-genotypes-and-phenotypes-using-i2b2
#17
Vivian S Gainer, Andrew Cagan, Victor M Castro, Stacey Duey, Bhaswati Ghosh, Alyssa P Goodson, Sergey Goryachev, Reeta Metta, Taowei David Wang, Nich Wattanasin, Shawn N Murphy
We have designed a Biobank Portal that lets researchers request Biobank samples and genotypic data, query associated electronic health records, and design and download datasets containing de-identified attributes about consented Biobank subjects. This do-it-yourself functionality puts a wide variety and volume of data at the fingertips of investigators, allowing them to create custom datasets for their clinical and genomic research from complex phenotypic data and quickly obtain corresponding samples and genomic data...
2016: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/26828522/the-changing-landscape-of-molecular-diagnostic-testing-implications-for-academic-medical-centers
#18
Heidi L Rehm, Elizabeth Hynes, Birgit H Funke
Over the last decade, the field of molecular diagnostics has undergone tremendous transformation, catalyzed by the clinical implementation of next generation sequencing (NGS). As technical capabilities are enhanced and current limitations are addressed, NGS is increasingly capable of detecting most variant types and will therefore continue to consolidate and simplify diagnostic testing. It is likely that genome sequencing will eventually serve as a universal first line test for disorders with a suspected genetic origin...
2016: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/26805892/the-information-technology-infrastructure-for-the-translational-genomics-core-and-the-partners-biobank-at-partners-personalized-medicine
#19
Natalie Boutin, Ana Holzbach, Lisa Mahanta, Jackie Aldama, Xander Cerretani, Kevin Embree, Irene Leon, Neeta Rathi, Matilde Vickers
The Biobank and Translational Genomics core at Partners Personalized Medicine requires robust software and hardware. This Information Technology (IT) infrastructure enables the storage and transfer of large amounts of data, drives efficiencies in the laboratory, maintains data integrity from the time of consent to the time that genomic data is distributed for research, and enables the management of complex genetic data. Here, we describe the functional components of the research IT infrastructure at Partners Personalized Medicine and how they integrate with existing clinical and research systems, review some of the ways in which this IT infrastructure maintains data integrity and security, and discuss some of the challenges inherent to building and maintaining such infrastructure...
2016: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/26805891/an-emerge-clinical-center-at-partners-personalized-medicine
#20
Jordan W Smoller, Elizabeth W Karlson, Robert C Green, Sekar Kathiresan, Daniel G MacArthur, Michael E Talkowski, Shawn N Murphy, Scott T Weiss
The integration of electronic medical records (EMRs) and genomic research has become a major component of efforts to advance personalized and precision medicine. The Electronic Medical Records and Genomics (eMERGE) network, initiated in 2007, is an NIH-funded consortium devoted to genomic discovery and implementation research by leveraging biorepositories linked to EMRs. In its most recent phase, eMERGE III, the network is focused on facilitating implementation of genomic medicine by detecting and disclosing rare pathogenic variants in clinically relevant genes...
2016: Journal of Personalized Medicine
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