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Frontiers of Medicine

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https://www.readbyqxmd.com/read/29441440/%C3%AE-%C3%AE-t-cells-in-liver-diseases
#1
REVIEW
Xuefu Wang, Zhigang Tian
γδ T cells display unique developmental, distributional, and functional patterns and can rapidly respond to various insults and contribute to diverse diseases. Different subtypes of γδ T cells are produced in the thymus prior to their migration to peripheral tissues. γδ T cells are enriched in the liver and exhibit liver-specific features. Accumulating evidence reveals that γδ T cells play important roles in liver infection, non-alcoholic fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regeneration...
February 14, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29423884/learning-curve-of-totally-thoracoscopic-pulmonary-segmentectomy
#2
LETTER
Weibing Wu, Jing Xu, Wei Wen, Yue Yu, Xinfeng Xu, Quan Zhu, Liang Chen
Totally thoracoscopic pulmonary segmentectomy (TTPS) is a feasible and safe technique that requires advanced thoracoscopic skills and knowledge of pulmonary anatomy. However, data describing the learning curve of TTPS have yet to be obtained. In this study, 128 patients who underwent TTPS between September 2010 and December 2013 were retrospectively analyzed to evaluate the learning curve and were divided chronologically into three phases, namely, ascending phase (A), plateau phase (B), and descending phase (C), through cumulative summation (CUSUM) for operative time (OT)...
February 9, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29374385/cyclospora-cayetanensis-infections-among-diarrheal-outpatients-in-shanghai-a-retrospective-case-study
#3
Yanyan Jiang, Zhongying Yuan, Guoqing Zang, Dan Li, Ying Wang, Yi Zhang, Hua Liu, Jianping Cao, Yujuan Shen
Cyclospora cayetanensis is a foodborne and waterborne pathogen that causes endemic and epidemic human diarrhea worldwide. A few epidemiological studies regarding C. cayetanensis infections in China have been conducted. During 2013, a total of 291 stool specimens were collected from patients with diarrhea at a hospital in urban Shanghai. C. cayetanensis was not detected in any of the stool specimens by traditional microscopy, whereas five stool specimens (1.72%, 5/291) were positive by PCR. These positive cases confirmed by molecular technology were all in the adult group (mean age 27...
January 26, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29372499/prevalence-and-molecular-characteristics-of-listeria-monocytogenes-in-cooked-products-and-its-comparison-with-isolates-from-listeriosis-cases
#4
Hong Wang, Lijuan Luo, Zhengdong Zhang, Jianping Deng, Yan Wang, Yimao Miao, Ling Zhang, Xi Chen, Xiang Liu, Songsong Sun, Bo Xiao, Qun Li, Changyun Ye
This study aimed to investigate the prevalence and molecular characteristics of Listeria monocytogenes in cooked products in Zigong City, China. The overall occurrence of the L. monocytogenes in the ready-to-eat (RTE) shops and mutton restaurants surveyed was 16.2% (141/873). An occurrence of 13.5% was observed in RTE pork, 6.5% in RTE vegetables, and more than 24.0% in either cooked mutton or cooked haggis. Serotype 1/2b (45.4%), 1/2a (33.3%), and 1/2c (14.2%) were the predominant types. By comparing the clonal complexes (CCs) based on multilocus sequence typing (MLST) of the L...
January 25, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29372498/pneumonic-plague-epidemic-in-northeast-china-in-1910-1911-dr-wu-lien-teh-s-epidemic-preventive-system-for-plague-control
#5
LETTER
Qingmeng Zhang, Fengmin Zhang, Baofeng Yang
Pneumonic plague that originated in Russian Siberia broke out in Northeast China in October 1910-March 1911. On the basis of field visits, autopsy, bacteriological identification, and close collaboration with local authorities and international colleagues, Dr. Wu Lien-Teh implemented a series of efficient antiplague measures, which successfully controlled the development of an extraordinary epidemic plague. In his subsequent work, Dr. Wu demonstrated the respiratory transmission of pneumonic plague and tarbagans' role in this spread...
January 25, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29368266/landscape-of-emerging-and-re-emerging-infectious-diseases-in-china-impact-of-ecology-climate-and-behavior
#6
REVIEW
Qiyong Liu, Wenbo Xu, Shan Lu, Jiafu Jiang, Jieping Zhou, Zhujun Shao, Xiaobo Liu, Lei Xu, Yanwen Xiong, Han Zheng, Sun Jin, Hai Jiang, Wuchun Cao, Jianguo Xu
For the past several decades, the infectious disease profile in China has been shifting with rapid developments in social and economic aspects, environment, quality of food, water, housing, and public health infrastructure. Notably, 5 notifiable infectious diseases have been almost eradicated, and the incidence of 18 additional notifiable infectious diseases has been significantly reduced. Unexpectedly, the incidence of over 10 notifiable infectious diseases, including HIV, brucellosis, syphilis, and dengue fever, has been increasing...
January 24, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29363038/responses-to-emerging-and-re-emerging-infectious-diseases-one-world-one-health
#7
EDITORIAL
Jianqing Xu, Jianguo Xu
No abstract text is available yet for this article.
January 23, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29363037/erratum-to-irreversible-phenotypic-perturbation-and-functional-impairment-of-b-cells-during-hiv-1-infection
#8
Jingjing Yan, Shuye Zhang, Jun Sun, Jianqing Xu, Xiaoyan Zhang
The original version of this article unfortunately contained a mistake. One of the authors of this article has been misspelled. Xiaoyang Zhang should be Xiaoyan Zhang. The update is also provided here.
January 20, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29352371/innate-and-adaptive-t-cells-in-influenza-disease
#9
REVIEW
Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H O Nguyen, Katherine Kedzierska
Influenza is a major global health problem, causing infections of the respiratory tract, often leading to acute pneumonia, life-threatening complications and even deaths. Over the last seven decades, vaccination strategies have been utilized to protect people from complications of influenza, especially groups at high risk of severe disease. While current vaccination regimens elicit strain-specific antibody responses, they fail to generate cross-protection against seasonal, pandemic and avian viruses. Moreover, vaccines designed to generate influenza-specific T-cell responses are yet to be optimized...
January 20, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29335835/etiology-of-invasive-candidosis-agents-in-russia-a-multicenter-epidemiological-survey
#10
N V Vasilyeva, E R Raush, M V Rudneva, T S Bogomolova, A E Taraskina, Yong Fang, Fengmin Zhang, N N Klimko
A multicenter prospective epidemiological survey on the etiologic agents of invasive candidosis was conducted in Russia in the period of 2012-2014. Samples were collected from 284 patients with invasive candidosis and Candida species isolated by culture. The species were identified by DNA sequencing and MALDI-TOF massspectrometry. A total of 322 isolates were recovered, in which 96% of Сandida species belonged to six major species, namely, C. albicans (43.2%), C. parapsilosis (20.2%), C. glabrata (11.5%), C...
January 16, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29380297/epidemiology-of-fungal-infections-in-china
#11
REVIEW
Min Chen, Yuan Xu, Nan Hong, Yali Yang, Wenzhi Lei, Lin Du, Jingjun Zhao, Xia Lei, Lin Xiong, Langqi Cai, Hui Xu, Weihua Pan, Wanqing Liao
With the increasing number of immunocompromised hosts, the epidemiological characteristics of fungal infections have undergone enormous changes worldwide, including in China. In this paper, we reviewed the existing data on mycosis across China to summarize available epidemiological profiles. We found that the general incidence of superficial fungal infections in China has been stable, but the incidence of tinea capitis has decreased and the transmission route has changed. By contrast, the overall incidence of invasive fungal infections has continued to rise...
January 11, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29357036/recent-transmission-of-mycobacterium-tuberculosis-in-china-the-implication-of-molecular-epidemiology-for-tuberculosis-control
#12
REVIEW
Chongguang Yang, Qian Gao
Tuberculosis (TB) has remained an ongoing concern in China. The national scale-up of the Directly Observed Treatment, Short Course (DOTS) program has accelerated the fight against TB in China. Nevertheless, many challenges still remain, including the spread of drug-resistant strains, high disease burden in rural areas, and enormous rural-to-urban migrations. Whether incident active TB represents recent transmission or endogenous reactivation has helped to prioritize the strategies for TB control. Evidence from molecular epidemiology studies has delineated the recent transmission of Mycobacterium tuberculosis (M...
January 11, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29318441/transforming-bacterial-disease-surveillance-and-investigation-using-whole-genome-sequence-to-probe-the-trace
#13
REVIEW
Biao Kan, Haijian Zhou, Pengcheng Du, Wen Zhang, Xin Lu, Tian Qin, Jianguo Xu
Two decades have passed since the first bacterial whole-genome sequencing, which provides new opportunity for microbial genome. Consequently, considerable genetic diversity encoded by bacterial genomes and among the strains in the same species has been revealed. In recent years, genome sequencing techniques and bioinformatics have developed rapidly, which has resulted in transformation and expedited the application of strategy and methodology for bacterial genome comparison used in dissection of infectious disease epidemics...
January 9, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29288283/associations-between-mycobacterium-tuberculosis-beijing-genotype-and-drug-resistance-to-four-first-line-drugs-a-survey-in-china
#14
Haican Liu, Yuanyuan Zhang, Zhiguang Liu, Jinghua Liu, Yolande Hauck, Jiao Liu, Haiyan Dong, Jie Liu, Xiuqin Zhao, Bing Lu, Yi Jiang, Gilles Vergnaud, Christine Pourcel, Kanglin Wan
Investigations on the genetic diversity of Mycobacterium tuberculosis in China have shown that Beijing genotype strains play a dominant role. To study the association between the M. tuberculosis Beijing genotype and the drug-resistance phenotype, 1286 M. tuberculosis clinical isolates together with epidemiological and clinical information of patients were collected from the center for tuberculosis (TB) prevention and control or TB hospitals in Beijing municipality and nine provinces or autonomous regions in China...
December 29, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/29282610/trends-of-foodborne-diseases-in-china-lessons-from-laboratory-based-surveillance-since-2011
#15
REVIEW
Jikai Liu, Li Bai, Weiwei Li, Haihong Han, Ping Fu, Xiaochen Ma, Zhenwang Bi, Xiaorong Yang, Xiuli Zhang, Shiqi Zhen, Xiaoling Deng, Xiumei Liu, Yunchang Guo
Foodborne disease is one of the most important public health issues worldwide. China faces various and unprecedented challenges in all aspects of the food chain. Data from laboratory-based foodborne disease surveillance systems from 2013 to 2016, as well as different regions and ages, can be found along with differences in the patterns of pathogens detected with diverse characteristics. Vibrio parahaemolyticus has been the leading cause of infectious diarrhea in China, especially among adults in coastal regions...
December 27, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/29260383/oxidative-stress-in-granulosa-cells-contributes-to-poor-oocyte-quality-and-ivf-et-outcomes-in-women-with-polycystic-ovary-syndrome
#16
Qiaohong Lai, Wenpei Xiang, Qing Li, Hanwang Zhang, Yufeng Li, Guijin Zhu, Chengliang Xiong, Lei Jin
The increased levels of intracellular reactive oxygen species (ROS) in granulosa cells (GCs) may affect the pregnancy results in women with polycystic ovary syndrome (PCOS). In this study, we compared the in vitro fertilization and embryo transfer (IVF-ET) results of 22 patients with PCOS and 25 patients with tubal factor infertility and detected the ROS levels in the GCs of these two groups. Results showed that the PCOS group had significantly larger follicles on the administration day for human chorionic gonadotropin than the tubal factor group (P < 0...
December 19, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/29247407/zfyve16-regulates-the-proliferation-of-b-lymphoid-cells
#17
Xuemei Zhao, Donghe Li, Qingsong Qiu, Bo Jiao, Ruihong Zhang, Ping Liu, Ruibao Ren
Zfyve16 (a.k.a. endofin or endosome-associated FYVE-domain protein), a member of the FYVE-domain protein family, is involved in endosomal trafficking and in TGF-β, BMP, and EGFR signaling. The FYVE protein SARA regulates the TGF-β signaling pathway by recruiting Smad2/3 and accelerating their phosphorylation, thereby altering their susceptibility to TGF-β-mediated T cell suppression. Zfyve16 binds to Smad4 and their binding affects the formation of Smad2/3-Smad4 complex in TGF-β signaling. However, the in vivo function of Zfyve16 remains unknown...
December 16, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/29230676/gut-microbial-balance-and-liver-transplantation-alteration-management-and-prediction
#18
REVIEW
Xinyao Tian, Zhe Yang, Fangzhou Luo, Shusen Zheng
Liver transplantation is a conventional treatment for terminal stage liver diseases. However, several complications still hinder the survival rate. Intestinal barrier destruction is widely observed among patients receiving liver transplant and suffering from ischemia-reperfusion or rejection injuries because of the relationship between the intestine and the liver, both in anatomy and function. Importantly, the resulting alteration of gut microbiota aggravates graft dysfunctions during the process. This article reviews the research progress for gut microbial alterations and liver transplantation...
December 12, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/29218679/possibility-of-women-treated-with-fertility-sparing-surgery-for-non-epithelial-ovarian-tumors-to-safely-and-successfully-become-pregnant-a-chinese-retrospective-cohort-study-among-148-cases
#19
Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li
This study was performed to evaluate the oncological and reproductive outcomes of childbearing-age women treated with fertility-sparing surgery (FSS) for non-epithelial ovarian tumors in China. One hundred and forty eight non-epithelial ovarian tumor women treated with FSS between January 1, 2000 and August 31, 2015 from two medical centers in China were identified. Progression-free survival (PFS) was 88.5%, whereas overall survival (OS) was 93.9%. Univariate analysis suggested that delivery after treatment is related to PFS (P = 0...
December 7, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/29218678/low-dose-ct-for-lung-cancer-screening-opportunities-and-challenges
#20
Hongbing Shen
Lung cancer is among the most frequently diagnosed cancers worldwide and the leading cause of cancer death in both males and females. Screening for lung cancer coupled with earlier intervention has long been studied as an approach to mortality reduction. However, minimal progress was achieved until recently, when lowdose spiral computed tomography (LDCT) screening demonstrated a 20% reduction in mortality from lung cancer in a randomized controlled trial (RCT), the National Lung Screening Trial, from the United States...
December 7, 2017: Frontiers of Medicine
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