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European Heart Journal

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https://www.readbyqxmd.com/read/30020442/neonatal-ecg-screening-and-qt-correction-the-march-towards-consistency-and-accuracy
#1
Robert H Pass, John D Fisher
No abstract text is available yet for this article.
July 17, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30020440/primary-prevention-implantable-cardioverter-defibrillator-and-opportunities-for-sudden-cardiac-death-risk-assessment-in-non-ischaemic-cardiomyopathy
#2
Rajeev K Pathak, Prashanthan Sanders, Rajat Deo
Sudden cardiac death (SCD) accounts for approximately one-third of all deaths among patients with non-ischaemic cardiomyopathy (NICM). Implantable cardioverter-defibrillator (ICD) therapy has been the primary intervention for managing individuals at high risk for SCD. However, individual ICD trials in the NICM population have failed to demonstrate a mortality benefit with prophylactic ICD implantation. Current guidelines recommend ICD implantation in NICM patients with symptomatic heart failure and a left ventricular ≤35% and are based on meta-analyses of multiple trials that span three decades and include the recent Danish Study to Assess the Efficacy of ICDs in Patients with Non-ischaemic Heart Failure on Mortality (DANISH) trial...
July 17, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30020433/frank-s-sign-diagonal-earlobe-crease
#3
Takanori Aizawa, Hiroki Shiomi, Kazuki Kitano, Takeshi Kimura
No abstract text is available yet for this article.
July 17, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30020432/paravalvular-root-abscess-with-mycotic-pseudoaneurysm
#4
William K F Kong, Chih Ching Choong, Jai Ajitchandra Sule, Kian Keong Poh, Theodoros Kofidis
No abstract text is available yet for this article.
July 17, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30020431/patent-foramen-ovale-and-long-term-risk-of-ischaemic-stroke-after-surgery
#5
Sabine Friedrich, Pauline Y Ng, Katharina Platzbecker, Sara M Burns, Valerie Banner-Goodspeed, Christian Weimar, Balachundhar Subramaniam, Timothy T Houle, Deepak L Bhatt, Matthias Eikermann
Aims: Pre-operatively diagnosed patent foramen ovale (PFO) is associated with an increased risk of ischaemic stroke within 30 days after surgery. This study aimed to assess the PFO-attributable ischaemic stroke risk beyond the perioperative period. Methods and results: This observational study of adult patients without history of stroke undergoing non-cardiac surgery with general anaesthesia examined the association of PFO with ischaemic stroke 1 and 2 years after surgery using multivariable logistic regression...
July 17, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30016425/bromocriptine-for-the-treatment-of-peripartum-cardiomyopathy-comparison-of-outcome-with-a-danish-cohort
#6
Anne Schjødt Ersbøll, Zoltan Arany, Finn Gustafsson
No abstract text is available yet for this article.
July 16, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30016421/reply-to-bromocriptine-for-the-treatment-of-peripartum-cardiomyopathy-comparison-of-outcome-with-a-nationwide-danish-cohort
#7
Denise Hilfiker-Kleiner, Karen Sliwa, Johann Bauersachs
No abstract text is available yet for this article.
July 16, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30010848/development-of-significant-tricuspid-regurgitation-over-time-and-prognostic-implications-new-insights-into-natural-history
#8
Edgard A Prihadi, Pieter van der Bijl, Erhan Gursoy, Rachid Abou, E Mara Vollema, Rebecca T Hahn, Gregg W Stone, Martin B Leon, Nina Ajmone Marsan, Victoria Delgado, Jeroen J Bax
Aims: To evaluate the risk factors influencing the development of significant (moderate and severe) tricuspid regurgitation (TR), and its impact on all-cause mortality in large registry of referral centre. Methods and results: In 1000 patients (mean age 68 ± 13 years; 50.9% male) with documented significant TR, clinical, and echocardiographic data were retrospectively analysed when the echocardiogram showed none/mild TR. Patients with congenital heart disease were excluded...
July 13, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30010740/the-electrocardiogram-and-the-phenotypic-expression-of-hypertrophic-cardiomyopathy
#9
Stefano Caselli, Antonio Pelliccia
No abstract text is available yet for this article.
July 13, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30010900/prospective-cohort-study-of-c-reactive-protein-as-a-predictor-of-clinical-events-in-adults-with-congenital-heart-disease-results-of-the-boston-adult-congenital-heart-disease-biobank
#10
Alexander R Opotowsky, Anne Marie Valente, Laith Alshawabkeh, Susan Cheng, Allison Bradley, Eric B Rimm, Michael J Landzberg
Aims: Despite the well-defined association of high-sensitivity hsCRP with cardiovascular outcomes in apparently healthy adults and those with acquired heart disease, the relevance of this inflammatory marker in adults with congenital heart disease (ACHD) remains unclear. We aimed to examine the clinical correlates and prognostic value of high-sensitivity C-reactive protein levels in ACHD. Methods and results: We conducted a prospective cohort study of (n = 707) outpatient ACHD (age 39 ± 14 years, 49% women), enrolled mainly at a referral centre, who had serum hsCRP measured in conjunction with a clinical assessment between 2012 and 2016...
July 12, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30010925/re-broken-and-remended-male-heart
#11
Iolanda Aquila, Maria Petullà, Daniele Torella, Ciro Indolfi
No abstract text is available yet for this article.
July 11, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30010924/disease-modelling-and-drug-discovery-for-hypertrophic-cardiomyopathy-using-pluripotent-stem-cells-how-far-have-we-come
#12
Chi Keung Lam, Joseph C Wu
No abstract text is available yet for this article.
July 11, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29992303/helping-to-understand-heart-failure-with-preserved-ejection-fraction
#13
Vanessa van Empel, Hans-Peter Brunner-La Rocca
No abstract text is available yet for this article.
July 9, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29992264/standardized-classification-and-framework-for-reporting-interpreting-and-analysing-medication-non-adherence-in-cardiovascular-clinical-trials-a-consensus-report-from-the-non-adherence-academic-research-consortium-narc
#14
Marco Valgimigli, Hector Garcia Garcia, Bernard Vrijens, Pascal Vranckx, Eugène P McFadden, Francesco Costa, Karen Pieper, David M Vock, Min Zhang, Gerrit-Anne Van Es, Pierluigi Tricoci, Usman Baber, Gabriel Steg, Gilles Montalescot, Dominick J Angiolillo, Patrick W Serruys, Andrew Farb, Stephan Windecker, Adnan Kastrati, Antonio Colombo, Fausto Feres, Peter Jüni, Gregg W Stone, Deepak L Bhatt, Roxana Mehran, Jan G P Tijssen
Non-adherence has been well recognized for years to be a common issue that significantly impacts clinical outcomes and health care costs. Medication adherence is remarkably low even in the controlled environment of clinical trials where it has potentially complex major implications. Collection of non-adherence data diverge markedly among cardiovascular randomized trials and, even where collected, is rarely incorporated in the statistical analysis to test the consistency of the primary endpoint(s). The imprecision introduced by the inconsistent assessment of non-adherence in clinical trials might confound the estimate of the calculated efficacy of the study drug...
July 9, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29986094/pulmonary-artery-rupture-during-right-heart-catheterization-successful-endovascular-treatment-with-amplatzer-vascular-plug
#15
Antonio Landi, Luca Nai Fovino, Tommaso Fabris, Massimo Napodano
No abstract text is available yet for this article.
July 6, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29982405/a-10-year-study-of-hospitalized-atrial-fibrillation-related-stroke-in-england-and-its-association-with-uptake-of-oral-anticoagulation
#16
J Campbell Cowan, Jianhua Wu, Marlous Hall, Andi Orlowski, Robert M West, Chris P Gale
Aims: To determine whether changing patterns of anticoagulant use in atrial fibrillation (AF) have impacted on stroke rates in England. Methods and results: English national databases, 2006-2016, were interrogated to assess stroke admissions and oral anticoagulant use. The number of patients with known AF increased linearly from 692 054 to 983 254 (prevalence 1.29% vs. 1.71%). Hospital episodes of AF-related stroke/100 000 AF patients increased from 80/week in 2006 to 98/week in 2011 and declined to 86/week in 2016 (2006-2011 difference 18...
July 5, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29982602/susceptibility-of-low-density-lipoprotein-particles-to-aggregate-depends-on-particle-lipidome-is-modifiable-and-associates-with-future-cardiovascular-deaths
#17
Maija Ruuth, Su Duy Nguyen, Terhi Vihervaara, Mika Hilvo, Teemu D Laajala, Pradeep Kumar Kondadi, Anton Gisterå, Hanna Lähteenmäki, Tiia Kittilä, Jenni Huusko, Matti Uusitupa, Ursula Schwab, Markku J Savolainen, Juha Sinisalo, Marja-Liisa Lokki, Markku S Nieminen, Antti Jula, Markus Perola, Seppo Ylä-Herttula, Lawrence Rudel, Anssi Öörni, Marc Baumann, Amos Baruch, Reijo Laaksonen, Daniel F J Ketelhuth, Tero Aittokallio, Matti Jauhiainen, Reijo Käkelä, Jan Borén, Kevin Jon Williams, Petri T Kovanen, Katariina Öörni
Aims: Low-density lipoprotein (LDL) particles cause atherosclerotic cardiovascular disease (ASCVD) through their retention, modification, and accumulation within the arterial intima. High plasma concentrations of LDL drive this disease, but LDL quality may also contribute. Here, we focused on the intrinsic propensity of LDL to aggregate upon modification. We examined whether inter-individual differences in this quality are linked with LDL lipid composition and coronary artery disease (CAD) death, and basic mechanisms for plaque growth and destabilization...
July 4, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29982362/pathological-phenotypes-of-ldl-particles
#18
Ulrich Laufs, Oliver Weingärtner
No abstract text is available yet for this article.
July 4, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29982592/pcsk9-deficiency-reduces-insulin-secretion-and-promotes-glucose-intolerance-the-role-of-the-low-density-lipoprotein-receptor
#19
Lorenzo Da Dalt, Massimiliano Ruscica, Fabrizia Bonacina, Gloria Balzarotti, Ashish Dhyani, Eliana Di Cairano, Andrea Baragetti, Lorenzo Arnaboldi, Simona De Metrio, Fabio Pellegatta, Liliana Grigore, Margherita Botta, Chiara Macchi, Patrizia Uboldi, Carla Perego, Alberico Luigi Catapano, Giuseppe Danilo Norata
Aims: PCSK9 loss of function genetic variants are associated with lower low-density lipoprotein cholesterol but also with higher plasma glucose levels and increased risk of Type 2 diabetes mellitus. Here, we investigated the molecular mechanisms underlying this association. Methods and results: Pcsk9 KO, WT, Pcsk9/Ldlr double KO (DKO), Ldlr KO, albumin AlbCre+/Pcsk9LoxP/LoxP (liver-selective Pcsk9 knock-out mice), and AlbCre-/Pcsk9LoxP/LoxP mice were used. GTT, ITT, insulin and C-peptide plasma levels, pancreas morphology, and cholesterol accumulation in pancreatic islets were studied in the different animal models...
July 2, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29982507/definition-of-hidden-drug-cardiotoxicity-paradigm-change-in-cardiac-safety-testing-and-its-clinical-implications
#20
Péter Ferdinandy, István Baczkó, Péter Bencsik, Zoltán Giricz, Anikó Görbe, Pál Pacher, Zoltán V Varga, András Varró, Rainer Schulz
Unexpected cardiac adverse effects are the leading causes of discontinuation of clinical trials and withdrawal of drugs from the market. Since the original observations in the mid-90s, it has been well established that cardiovascular risk factors and comorbidities (such as ageing, hyperlipidaemia, and diabetes) and their medications (e.g. nitrate tolerance, adenosine triphosphate-dependent potassium inhibitor antidiabetic drugs, statins, etc.) may interfere with cardiac ischaemic tolerance and endogenous cardioprotective signalling pathways...
July 2, 2018: European Heart Journal
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