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European Heart Journal

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https://www.readbyqxmd.com/read/29790954/clinical-use-of-intracoronary-imaging-part-1-guidance-and-optimization-of-coronary-interventions-an-expert-consensus-document-of-the-european-association-of-percutaneous-cardiovascular-interventions-endorsed-by-the-chinese-society-of-cardiology
#1
Lorenz Räber, Gary S Mintz, Konstantinos C Koskinas, Thomas W Johnson, Niels R Holm, Yoshinubo Onuma, Maria D Radu, Michael Joner, Bo Yu, Haibo Jia, Nicolas Menevau, Jose M de la Torre Hernandez, Javier Escaned, Jonathan Hill, Francesco Prati, Antonio Colombo, Carlo di Mario, Evelyn Regar, Davide Capodanno, William Wijns, Robert A Byrne, Giulio Guagliumi
This Consensus Document is the first of two reports summarizing the views of an expert panel organized by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) on the clinical use of intracoronary imaging including intravascular ultrasound (IVUS) and optical coherence tomography (OCT). The first document appraises the role of intracoronary imaging to guide percutaneous coronary interventions (PCIs) in clinical practice. Current evidence regarding the impact of intracoronary imaging guidance on cardiovascular outcomes is summarized, and patients or lesions most likely to derive clinical benefit from an imaging-guided intervention are identified...
May 22, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29788351/uninterrupted-apixaban-for-atrial-fibrillation-ablation-is-a-reasonable-alternative-but-what-is-the-significance-of-silent-cerebral-infarctions
#2
Daniel J Friedman, Christopher B Granger
No abstract text is available yet for this article.
May 19, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29788263/temporal-course-of-vascular-healing-and-neoatherosclerosis-after-implantation-of-durable-or-biodegradable-polymer-drug-eluting-stents
#3
Giulio Guagliumi, Kunihiro Shimamura, Vasile Sirbu, Roberto Garbo, Giacomo Boccuzzi, Angelina Vassileva, Orazio Valsecchi, Luigi Fiocca, Paolo Canova, Francesco Colombo, Gabriel Tensol Rodriguez Pereira, Daisuke Nakamura, Guilherme F Attizzani, Alberto Cereda, Keisuke Satogami, Leonardo De Luca, Francesco Saia, Davide Capodanno
Aims: Delayed healing and endothelial dysfunction may occur with drug-eluting stents (DES), promoting accelerated infiltration of lipids in the neointima and development of neoatherosclerosis (NA). Pathology data suggest durable polymer (DP) of DES to play a major role in this process. Whether biodegradable polymer (BP) may address these issues is uncertain. We compared in vivo vessel healing and NA of current generation BP- or DP-DES using serial optical coherence tomography (OCT) assessments...
May 19, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29788047/haemodynamics-dyspnoea-and-pulmonary-reserve-in-heart-failure-with-preserved-ejection-fraction
#4
Masaru Obokata, Thomas P Olson, Yogesh N V Reddy, Vojtech Melenovsky, Garvan C Kane, Barry A Borlaug
Aims: Increases in left ventricular filling pressure are a fundamental haemodynamic abnormality in heart failure with preserved ejection fraction (HFpEF). However, very little is known regarding how elevated filling pressures cause pulmonary abnormalities or symptoms of dyspnoea. We sought to determine the relationships between simultaneously measured central haemodynamics, symptoms, and lung ventilatory and gas exchange abnormalities during exercise in HFpEF. Methods and results: Subjects with invasively-proven HFpEF (n = 50) and non-cardiac causes of dyspnoea (controls, n = 24) underwent cardiac catheterization at rest and during exercise with simultaneous expired gas analysis...
May 19, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29788044/clinical-and-haemodynamic-outcomes-of-balloon-expandable-transcatheter-mitral-valve-implantation-a-7-year-experience
#5
Marina Urena, Eric Brochet, Milena Lecomte, Caroline Kerneis, Jose Luis Carrasco, Walid Ghodbane, Jérémie Abtan, Soleiman Alkhoder, Richard Raffoul, Bernard Iung, Patrick Nataf, Alec Vahanian, Dominique Himbert
Aims: We analysed the early and long-term clinical and haemodynamic outcomes of balloon-expandable transcatheter mitral valve implantation (TMVI) in an experienced centre. Methods and results: All patients undergoing TMVI from July 2010 to July 2017 in our centre were prospectively included. Indication for TMVI relied on the judgement of the local heart team. Patients were followed at 1 month, 1 year, and yearly thereafter. A total of 91 patients underwent TMVI...
May 19, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29788143/pedunculated-aortic-thrombus-propagating-from-the-right-coronary-artery-in-a-patient-with-iga-nephropathy
#6
Jacques Scherman, Natercia da Silva, Adriaan Myburgh, Timothy Pennel
No abstract text is available yet for this article.
May 16, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29788103/post-ischaemic-administration-of-the-murine-canakinumab-surrogate-antibody-improves-outcome-in-experimental-stroke
#7
Luca Liberale, Candela Diaz-Cañestro, Nicole R Bonetti, Francesco Paneni, Alexander Akhmedov, Jürg H Beer, Fabrizio Montecucco, Thomas F Lüscher, Giovanni G Camici
Aims: The CANTOS trial underscored the efficacy of selective antibody-based interleukin (IL)-1β inhibition with Canakinumab in secondary prevention of cardiovascular events. Despite the success of the trial, incidence of stroke was not reduced likely due to the low number of events and the relatively young age of patients enrolled. Given the established role of IL-1β in stroke, we tested the efficacy of the murine Canakinumab-equivalent antibody in a mouse model of ischaemic stroke...
May 16, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29788101/left-ventricular-stroke-volume-in-severe-aortic-stenosis-and-preserved-left-ventricular-ejection-fraction-prognostic-relevance
#8
Victoria Delgado, Jeroen J Bax
No abstract text is available yet for this article.
May 16, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29771312/is-defective-cholesterol-efflux-an-integral-inflammatory-component-in-myelopoiesis-driven-cardiovascular-diseases
#9
Laurent Yvan-Charvet, Filip K Swirski
No abstract text is available yet for this article.
May 15, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29771305/yet-another-echocardiographic-index-do-we-need-more
#10
Thor Edvardsen, Anders Opdahl
No abstract text is available yet for this article.
May 15, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29750272/gut-microbial-diversity-is-associated-with-lower-arterial-stiffness-in-women
#11
Cristina Menni, Chihung Lin, Marina Cecelja, Massimo Mangino, Maria Luisa Matey-Hernandez, Louise Keehn, Robert P Mohney, Claire J Steves, Tim D Spector, Chang-Fu Kuo, Phil Chowienczyk, Ana M Valdes
Aims: The gut microbiome influences metabolic syndrome (MetS) and inflammation and is therapeutically modifiable. Arterial stiffness is poorly correlated with most traditional risk factors. Our aim was to examine whether gut microbial composition is associated with arterial stiffness. Methods and results: We assessed the correlation between carotid-femoral pulse wave velocity (PWV), a measure of arterial stiffness, and gut microbiome composition in 617 middle-aged women from the TwinsUK cohort with concurrent serum metabolomics data...
May 9, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29741615/the-incidence-and-prognostic-implications-of-worsening-right-ventricular-function-after-surgical-or-transcatheter-aortic-valve-replacement-insights-from-partner-iia
#12
Paul C Cremer, Yiran Zhang, Maria Alu, L Leonardo Rodriguez, Brian R Lindman, Alan Zajarias, Rebecca T Hahn, Stamatios Lerakis, S Chris Malaisrie, Pamela S Douglas, Philippe Pibarot, Lars G Svensson, Martin B Leon, Wael A Jaber
Aims: In patients randomized to transcatheter or surgical aortic valve replacement (TAVR, SAVR), we sought to determine whether SAVR is associated with worsening right ventricular (RV) function and whether RV deterioration is associated with mortality. Methods and results: In 1376 patients from PARTNERIIA with paired baseline and 30-day core lab echocardiograms, worsening RV function was defined as decline by at least one grade from baseline to 30 days. Our primary outcome was all-cause mortality from 30 days to 2 years...
May 8, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29741611/crispr-cas9-editing-in-human-pluripotent-stem-cell-cardiomyocytes-highlights-arrhythmias-hypocontractility-and-energy-depletion-as-potential-therapeutic-targets-for-hypertrophic-cardiomyopathy
#13
Diogo Mosqueira, Ingra Mannhardt, Jamie R Bhagwan, Katarzyna Lis-Slimak, Puspita Katili, Elizabeth Scott, Mustafa Hassan, Maksymilian Prondzynski, Stephen C Harmer, Andrew Tinker, James G W Smith, Lucie Carrier, Philip M Williams, Daniel Gaffney, Thomas Eschenhagen, Arne Hansen, Chris Denning
Aims: Sarcomeric gene mutations frequently underlie hypertrophic cardiomyopathy (HCM), a prevalent and complex condition leading to left ventricle thickening and heart dysfunction. We evaluated isogenic genome-edited human pluripotent stem cell-cardiomyocytes (hPSC-CM) for their validity to model, and add clarity to, HCM. Methods and results: CRISPR/Cas9 editing produced 11 variants of the HCM-causing mutation c.C9123T-MYH7 [(p.R453C-β-myosin heavy chain (MHC)] in 3 independent hPSC lines...
May 8, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29733360/response-to-liver-fat-content-non-alcoholic-fatty-liver-disease-and-ischaemic-heart-disease
#14
Stefan Stender, Anne Tybjaerg-Hansen
No abstract text is available yet for this article.
May 3, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29726941/hiv-and-cardiovascular-disease-much-ado-about-nothing
#15
Gary S Ma, Bruno R Cotter
No abstract text is available yet for this article.
May 3, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29726934/liver-fat-content-non-alcoholic-fatty-liver-disease-and-risk-of-ischaemic-heart-disease
#16
Christopher D Byrne, Giovanni Targher
No abstract text is available yet for this article.
May 3, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29726927/erratum
#17
(no author information available yet)
No abstract text is available yet for this article.
May 2, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29722801/cardioprotection-research-must-leave-its-comfort-zone
#18
Gerd Heusch
No abstract text is available yet for this article.
May 2, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29722796/a-randomized-multicentre-trial-to-compare-revascularization-with-optimal-medical-therapy-for-the-treatment-of-chronic-total-coronary-occlusions
#19
Gerald S Werner, Victoria Martin-Yuste, David Hildick-Smith, Nicolas Boudou, Georgios Sianos, Valery Gelev, Jose Ramon Rumoroso, Andrejs Erglis, Evald Høj Christiansen, Javier Escaned, Carlo di Mario, Thomas Hovasse, Luis Teruel, Alexander Bufe, Bernward Lauer, Kris Bogaerts, Javier Goicolea, James C Spratt, Anthony H Gershlick, Alfredo R Galassi, Yves Louvard
Aims: The clinical value of percutaneous coronary intervention (PCI) for chronic coronary total occlusions (CTOs) is not established by randomized trials. This study should compare the benefit of PCI vs. optimal medical therapy (OMT) on the health status in patients with at least one CTO. Method and results: Three hundred and ninety-six patients were enrolled in a prospective randomized, multicentre, open-label, and controlled clinical trial to compare the treatment by PCI with OMT with a 2:1 randomization ratio...
May 2, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29718318/a-rare-cause-of-pericardial-effusion-due-to-intracardiac-cement-embolism
#20
Patrick Swojanowsky, Maria Brinkmeier-Theofanopoulou, Claus Schmitt, Uwe Mehlhorn
No abstract text is available yet for this article.
April 30, 2018: European Heart Journal
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