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European Heart Journal

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https://www.readbyqxmd.com/read/29165585/lamin-a-c-mutations-in-patients-with-dilated-cardiomyopathy
#1
Sabine Pankuweit
No abstract text is available yet for this article.
November 20, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29165549/prognostic-impacts-of-rho-kinase-activity-in-circulating-leucocytes-in-patients-with-vasospastic-angina
#2
Taro Nihei, Jun Takahashi, Kiyotaka Hao, Yoku Kikuchi, Yuji Odaka, Ryuji Tsuburaya, Kensuke Nishimiya, Yasuharu Matsumoto, Kenta Ito, Satoshi Miyata, Yasuhiko Sakata, Hiroaki Shimokawa
Aims: Rho-kinase activity in circulating leucocytes is a useful biomarker for diagnosis and disease activity assessment of vasospastic angina (VSA). The present study aimed to examine the long-term prognostic impact of Rho-kinase activity in circulating leucocytes in VSA patients. Methods and results: We prospectively enrolled 174 consecutive patients with VSA and 50 non-VSA patients, in whom we measured Rho-kinase activity in circulating leucocytes, and they were followed for a median of 16 months...
November 20, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29165548/affairs-of-the-heart-outcomes-in-men-and-women-with-hypertrophic-cardiomyopathy
#3
Constantinos O'Mahony, Perry Elliott
No abstract text is available yet for this article.
November 20, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29165556/resumption-of-oral-anticoagulation-following-traumatic-injury-and-risk-of-stroke-and-bleeding-in-patients-with-atrial-fibrillation-a-nationwide-cohort-study
#4
Laila Staerk, Emil Loldrup Fosbøl, Morten Lamberts, Anders Nissen Bonde, Kasper Gadsbøll, Caroline Sindet-Pedersen, Ellen A Holm, Thomas Alexander Gerds, Brice Ozenne, Gregory Y H Lip, Christian Torp-Pedersen, Gunnar Hilmar Gislason, Jonas Bjerring Olesen
Aims: We examined the risks of all-cause mortality, stroke, major bleeding, and recurrent traumatic injury associated with resumption of vitamin K antagonists (VKAs) and non-VKAs oral anticoagulants (NOACs) following traumatic injury in atrial fibrillation (AF) patients. Methods and results: This was a Danish nationwide registry-based study (2005-16), including 4541 oral anticoagulant (OAC)-treated AF patients experiencing traumatic injury (defined as traumatic brain injury, hip fracture, or traumatic torso or abdominal injury)...
November 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29165554/the-effect-of-1-5%C3%A2-t-cardiac-magnetic-resonance-on-human-circulating-leucocytes
#5
William R Critchley, Anna Reid, Julie Morris, Josephine H Naish, John P Stone, Alexandra L Ball, Triin Major, David Clark, Nick Waldron, Christien Fortune, Jakub Lagan, Gavin A Lewis, Mark Ainslie, Erik B Schelbert, Daniel M Davis, Matthias Schmitt, James E Fildes, Christopher A Miller
Aims: Investigators have proposed that cardiovascular magnetic resonance (CMR) should have restrictions similar to those of ionizing imaging techniques. We aimed to investigate the acute effect of 1.5 T CMR on leucocyte DNA integrity, cell counts, and function in vitro, and in a large cohort of patients in vivo. Methods and results: In vitro study: peripheral blood mononuclear cells (PBMCs) were isolated from healthy volunteers, and histone H2AX phosphorylation (γ-H2AX) expression, leucocyte counts, and functional parameters were quantified using flow cytometry under the following conditions: (i) immediately following PBMC isolation, (ii) after standing on the benchside as a temperature and time control, (iii) after a standard CMR scan...
November 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29161405/quantifying-infective-endocarditis-risk-in-patients-with-predisposing-cardiac-conditions
#6
Martin H Thornhill, Simon Jones, Bernard Prendergast, Larry M Baddour, John B Chambers, Peter B Lockhart, Mark J Dayer
Aims: There are scant comparative data quantifying the risk of infective endocarditis (IE) and associated mortality in individuals with predisposing cardiac conditions. Methods and results: English hospital admissions for conditions associated with increased IE risk were followed for 5 years to quantify subsequent IE admissions. The 5-year risk of IE or dying during an IE admission was calculated for each condition and compared with the entire English population as a control...
November 17, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29161374/the-challenges-of-antithrombotic-therapy-in-patients-with-left-ventricular-thrombosis
#7
Wael Sumaya, Robert F Storey
No abstract text is available yet for this article.
November 17, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29155984/cysteine-rich-angiogenic-inducer-61-cyr61-a-novel-soluble-biomarker-of-acute-myocardial-injury-improves-risk-stratification-after-acute-coronary-syndromes
#8
Roland Klingenberg, Soheila Aghlmandi, Christoph Liebetrau, Lorenz Räber, Baris Gencer, David Nanchen, David Carballo, Alexander Akhmedov, Fabrizio Montecucco, Stefan Zoller, Chad Brokopp, Dik Heg, Peter Jüni, Helena Marti Soler, Pedro-Manuel Marques-Vidal, Peter Vollenweider, Oliver Dörr, Nicolas Rodondi, François Mach, Stephan Windecker, Ulf Landmesser, Arnold von Eckardstein, Christian W Hamm, Christian M Matter, Thomas F Lüscher
Aims: We aimed to identify a novel biomarker involved in the early events leading to an acute coronary syndrome (ACS) and evaluate its role in diagnosis and risk stratification. Methods and results: Biomarker identification was based on gene expression profiling. In coronary thrombi of ACS patients, cysteine-rich angiogenic inducer 61 (Cyr61, CCN1) gene transcripts were highly up-regulated compared with peripheral mononuclear cells. In a murine ischaemia-reperfusion model (I/R), myocardial Cyr61 expression was markedly increased compared with the controls...
November 16, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29140425/annular-rupture-during-transcatheter-aortic-valve-replacement-novel-treatment-with-amplatzer-vascular-plugs
#9
Mohamad Alkhouli, Elizabeth Carpenter, Abdul Tarabishy, Partho Sengupta
No abstract text is available yet for this article.
November 13, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29140424/cholesterol-variability-a-marker-for-increased-risk-or-a-risk-factor
#10
Sripal Bangalore
No abstract text is available yet for this article.
November 13, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29140410/rare-coronary-anomaly-with-hemodynamic-consequence-squeezing-of-the-right-coronary-artery
#11
Andrea Denegri, Nooraldaem Yousif, Robert Manka, Hatem Alkadhi, Willibald Maier
No abstract text is available yet for this article.
November 13, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29136146/the-abc-death-risk-score-is-it-time-to-start-measuring-gdf-15
#12
M Benjamin Shoemaker, William G Stevenson
No abstract text is available yet for this article.
November 10, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29136138/calcific-aortic-valve-stenosis-hard-disease-in-the-heart-a-biomolecular-approach-towards-diagnosis-and-treatment
#13
Frederique E C M Peeters, Steven J R Meex, Marc R Dweck, Elena Aikawa, Harry J G M Crijns, Leon J Schurgers, Bas L J H Kietselaer
Calcific aortic valve stenosis (CAVS) is common in the ageing population and set to become an increasing economic and health burden. Once present, it inevitably progresses and has a poor prognosis in symptomatic patients. No medical therapies are proven to be effective in holding or reducing disease progression. Therefore, aortic valve replacement remains the only available treatment option. Improved knowledge of the mechanisms underlying disease progression has provided us with insights that CAVS is not a passive disease...
November 10, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29136136/a-battle-in-the-crusade-to-understand-scimitar-syndrome
#14
Alexander R Opotowsky, Gary D Webb
No abstract text is available yet for this article.
November 10, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29136134/asymptomatic-dissection-of-a-giant-aorta-ascendens-aneurysm-in-turner-syndrome
#15
Piotr Dobrowolski, Anna Klisiewicz, Ilona Michalowska, Mariusz Kusmierczyk, Piotr Hoffman
No abstract text is available yet for this article.
November 10, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29136142/the-forkhead-transcription-factor-foxo3-negatively-regulates-natural-killer-cell-function-and-viral-clearance-in-myocarditis
#16
Madlen Loebel, Luise Holzhauser, Jelka A Hartwig, Praphulla C Shukla, Konstantinos Savvatis, Alexander Jenke, Martina Gast, Felicitas Escher, Sonya C Becker, Sandra Bauer, Andrea Stroux, Antje Beling, Meike Kespohl, Sandra Pinkert, Henry Fechner, Uwe Kuehl, Dirk Lassner, Wolfgang Poller, Heinz-Peter Schultheiss, Tanja Zeller, Stefan Blankenberg, Anna-Pia Papageorgiou, Stephane Heymans, Ulf Landmesser, Carmen Scheibenbogen, Carsten Skurk
Aims: Foxo3 is a transcription factor involved in cell metabolism, survival, and inflammatory disease. However, mechanistic insight in Foxo3 effects is still limited. Here, we investigated the role of Foxo3 on natural killer (NK) cell responses and its effects in viral myocarditis. Methods and results: Effects of Foxo3 on viral load and immune responses were investigated in a model of coxsackie virus B3 myocarditis in wild-type (WT) and Foxo3 deficient mice. Reduced immune cell infiltration, viral titres, and pro-inflammatory cytokines in cardiac tissue were observed in Foxo3-/- mice 7 days post-infection (p...
November 9, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29126266/non-insulin-antidiabetic-pharmacotherapy-in-patients-with-established-cardiovascular-disease-a-position-paper-of-the-european-society-of-cardiology-working-group-on-cardiovascular-pharmacotherapy
#17
Alexander Niessner, Juan Tamargo, Lorenz Koller, Christoph H Saely, Thomas Andersen Schmidt, Gianluigi Savarese, Sven Wassmann, Giuseppe Rosano, Claudio Ceconi, Christian Torp-Pedersen, Juan Carlos Kaski, Keld Per Kjeldsen, Stefan Agewall, Thomas Walther, Heinz Drexel, Basil S Lewis
No abstract text is available yet for this article.
November 8, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29096007/diagnosis-of-active-pericarditis-by-positron-emission-tomography-pet-cardiac-magnetic-resonance-cmr-imaging
#18
Bo Xu, Steve Shih-Lin Huang, Christine Jellis, Scott D Flamm
No abstract text is available yet for this article.
October 31, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29095976/lamin-a-c-cardiomyopathy-young-onset-high-penetrance-and-frequent-need-for-heart-transplantation
#19
Nina Eide Hasselberg, Trine Fink Haland, Jørg Saberniak, Pål Haugar Brekke, Knut Erik Berge, Trond Paul Leren, Thor Edvardsen, Kristina Hermann Haugaa
Aims: Lamin A/C (LMNA) mutations cause familial dilated cardiomyopathy (DCM) with frequent conduction blocks and arrhythmias. We explored the prevalence, cardiac penetrance, and expressivity of LMNA mutations among familial DCM in Norway. Furthermore, we explored the risk factors and the outcomes in LMNA patients. Methods and results: During 2003-15, genetic testing was performed in patients referred for familial DCM. LMNA genotype-positive subjects were examined by electrocardiography, Holter monitoring, cardiac magnetic resonance imaging, and echocardiography...
October 31, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29095969/first-in-man-implantation-of-a-pre-packaged-self-expandable-dry-tissue-transcatheter-aortic-valve
#20
Yuan Feng, Zhen-Gang Zhao, Jorge Baccaro, Min Frank Zeng, R David Fish, Mao Chen
No abstract text is available yet for this article.
October 31, 2017: European Heart Journal
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