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British Journal of Haematology

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https://www.readbyqxmd.com/read/30430556/interim-fdg-pet-does-not-predict-outcome-in-advanced-stage-hodgkin-lymphoma-patients-treated-with-beacopp
#1
LETTER
Hugo J A Adams, Thomas C Kwee
No abstract text is available yet for this article.
November 14, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30430539/sickle-cell-screening-in-europe-the-time-has-come
#2
EDITORIAL
Lisa M Shook, Russell E Ware
No abstract text is available yet for this article.
November 14, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30426480/hepatitis-e-virus-infection-after-haploidentical-haematopoietic-stem-cell-transplantation-incidence-and-clinical-course
#3
Fei-Fei Tang, Xiao-Dong Mo, Yu Wang, Chen-Hua Yan, Yu-Hong Chen, Huan Chen, Wei Han, Ying-Jun Chang, Hai-Ying Zhang, Yan-Di Xie, Hui Ma, Lai Wei, Lan-Ping Xu, Xiao-Jun Huang, Xiao-Hui Zhang
Hepatitis E virus (HEV) is increasingly found to cause hepatitis in allogeneic haematopoietic stem cell transplantation (HSCT) patients. However, little is known about HEV infection in patients receiving haploidentical HSCT (haplo-HSCT). Here, we retrospectively evaluate the incidence and clinical course of HEV infection in haplo-HSCT patients. From January 2014 to July 2017, 177 patients with unexplained elevated transaminases after receiving haplo-HSCT at Peking University Institute of Haematology were screened for HEV using HEV serology...
November 13, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30426472/a-guideline-for-the-management-of-specific-situations-in-polycythaemia-vera-and-secondary-erythrocytosis-a-british-society-for-haematology-guideline
#4
Mary F F McMullin, Adam J Mead, Sahra Ali, Catherine Cargo, Frederick Chen, Joanne Ewing, Mamta Garg, Anna Godfrey, Steven Knapper, Donal P McLornan, Jyoti Nangalia, Mallika Sekhar, Frances Wadelin, Claire N Harrison
No abstract text is available yet for this article.
November 13, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30426471/circulating-dendritic-cells-deficiencies-as-a-new-biomarker-in-classical-hodgkin-lymphoma
#5
Domenico Galati, Serena Zanotta, Gaetano Corazzelli, Dario Bruzzese, Gaetana Capobianco, Emanuela Morelli, Manuela Arcamone, Rosaria De Filippi, Antonio Pinto
No robust biomarkers have been yet validated to identify the recurrence of disease in classical Hodgkin Lymphoma (cHL) patients upon induction treatment. The relevance of the inflammatory microenvironment in cHL prompted us to investigate the key immunomodulator myeloid dendritic cells type-1 (mDC1), type-2 (mDC2) and plasmacytoid dendritic cells (pDC). Blood DC levels were assessed in 52 newly diagnosed patients through multiparametric flow-cytometry. All but two patients received ABVD regimen (doxorubicin, bleomycin, vinblastine, dacarbazine)...
November 13, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30426468/acute-promyelocytic-leukaemia-with-increased-basophils
#6
Juan Zhang, Mingyong Li, Yuan He
No abstract text is available yet for this article.
November 13, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30421536/incidence-and-risk-factors-for-clinical-neurodegenerative-langerhans-cell-histiocytosis-a-longitudinal-cohort-study
#7
Sébastien Héritier, Mohamed-Aziz Barkaoui, Jean Miron, Caroline Thomas, Despina Moshous, Anne Lambilliotte, Françoise Mazingue, Kamila Kebaili, Eric Jeziorski, Geneviève Plat, Nathalie Aladjidi, Hélène Pacquement, Claire Galambrun, Laurence Brugières, Guy Leverger, Ludovic Mansuy, Catherine Paillard, Anne Deville, Anne Pagnier, Anne Lutun, Marion Gillibert-Yvert, Jean-Louis Stephan, Fleur Cohen-Aubart, Julien Haroche, Isabelle Pellier, Fréderic Millot, Virginie Gandemer, Nadine Martin-Duverneuil, Valérie Taly, Zofia Hélias-Rodzewicz, Jean-François Emile, Khe Hoang-Xuan, Ahmed Idbaih, Jean Donadieu
Neurodegenerative (ND) complications in Langerhans cell histiocytosis (LCH) are a late-onset but dramatic sequelae for which incidence and risk factors are not well defined. Based on a national prospective registry of paediatric LCH patients, we determined the incidence rate of clinical ND LCH (cND-LCH) and analysed risk factors, taking into account disease extent and molecular characteristics. Among 1897 LCH patients, 36 (1·9%) were diagnosed with a cND-LCH. The 10-year cumulative incidence of cND-LCH was 4·1%...
November 12, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30417946/the-translational-science-of-hodgkin-lymphoma
#8
REVIEW
Melita Cirillo, Sarah Reinke, Wolfram Klapper, Sven Borchmann
Hodgkin Lymphoma (HL) is an unusual B-cell lymphoma because the malignant cells exist as a minority population in a densely cellular microenvironment. The microenvironment is comprised predominately of inflammatory and immune cells with fibrosis in some cases. There are multiple dysregulated signalling pathways that sustain HL within this microenvironment, such as the Nuclear factor-κB and Janus kinase/signal transducers and activators of transcription pathways. Advances in genomic medicine have enabled a better characterisation of the rare tumour cells and improved our understanding of the signalling mechanisms that exist between the malignant cell and its microenvironment...
November 12, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30417943/prognostic-impact-of-trisomy-21-in-follicular-lymphoma
#9
Takeki Mitsui, Akihiko Yokohama, Hiromi Koiso, Akio Saito, Kohtaro Toyama, Hiroaki Shimizu, Takuma Ishizaki, Hiroyuki Irisawa, Makiko Takizawa, Takayuki Saitoh, Kayoko Murayama, Morio Matsumoto, Hiroshi Handa, Junko Hirato, Masaru Kojima, Hirokazu Murakami, Norifumi Tsukamoto
The chromosomal abnormalities associated with follicular lymphoma (FL) prognosis are not fully elucidated. Here, we evaluated the pattern of chromosomal abnormalities in FL, and clarified the correlations between the cytogenetic features and clinical outcome. Cytogenetic analysis was performed using standard methods of Giemsa-banding at diagnosis for 201 FL patients admitted to our hospitals between 2001 and 2013. The identified chromosomal abnormalities were: t(14;18)(q32;q21) (59·2%), +X (17·9%), del(6)(q)/-6 (16·9%), +7 (14·4%), abnormality of 1q12-21/1q (12·9%), del(13)(q)/-13 (11·9%), abnormality of 3q27 (10·4%), abnormality of 10q22-24 (10·0%), +12/dup(12)(q) (10·0%), abnormality of 1p21-22/1p (9·0%), +18 (9·0%), del(17)(p)/-17 (5·0%), and a complex karyotype (54·7%)...
November 12, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30417925/elevated-fetal-haemoglobin-levels-are-associated-with-decreased-incidence-of-retinopathy-in-adults-with-sickle-cell-disease
#10
Umar K Mian, Joyce Tang, Ana P M Allende, Moonseong Heo, Nicole Bernstein, Leena Vattappally, Daniel Schoenfeld, Caterina P Minniti
Among the many vascular complications of sickle cell disease (SCD), retinopathy is the most prevalent and represents a leading cause of blindness. Hydroxycarbamide therapy ameliorates many symptoms of SCD, and high fetal haemoglobin (HbF) levels have been shown to protect against the development of retinopathy in children with HbSS. Its effect on adults with SCD, who are at a much higher risk of developing retinopathy, has not been studied. We aimed to investigate the effect of hydroxycarbamide use and HbF level on sickle cell retinopathy development in adults...
November 12, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30408164/dose-limiting-stomatitis-associated-with-ibrutinib-therapy-a-case-series
#11
LETTER
Emmanuelle Vigarios, Marie Beylot-Barry, Marie-Hélène Jegou, Luice Oberic, Loïc Ysebaert, Vincent Sibaud
No abstract text is available yet for this article.
November 8, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30408160/the-effect-on-lymphocyte-subsets-of-decreasing-stopping-tyrosine-kinase-inhibitor-therapy-in-chronic-myeloid-leukaemia-data-from-the-destiny-trial
#12
LETTER
Gemma M Austin, Katy Knight, Joanne Bell, Anthony Carter, Earnest Heartin, David Watson, Letizia Foroni, Stephen E Christmas, Fotios Polydoros, Richard E Clark
No abstract text is available yet for this article.
November 8, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30408157/understanding-how-older-age-drives-decision-making-and-outcome-in-immune-thrombocytopenia-a-single-centre-study-on-465-adult-patients
#13
Francesca Palandri, Lucia Catani, Giuseppe Auteri, Daniela Bartoletti, Sofia Fatica, Alessio Fusco, Maria L Bacchi Reggiani, Michele Cavo, Nicola Vianelli
We analysed the impact of older age on the management of immune thrombocytopenia (ITP) in 465 adult patients diagnosed between 1995 and 2017 and followed at our institution for a minimum of 12 months. Over a follow-up of 4248 patient-years, front-line corticosteroids therapy was required in 334 patients (71·8%), mainly (85·3%) within 1 year from diagnosis. Need for first-, second- and third-line therapy was comparable in younger and older (age ≥65 years, n = 154) patients. Older patients presented more frequently with severe haemorrhages, started therapy with a higher platelet count and received lower dose front-line corticosteroids; thereafter, they were preferentially treated with mild immunosuppressive therapies/thrombopoietin-receptor agonists...
November 8, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30408156/current-treatment-paradigms-for-advanced-stage-hodgkin-lymphoma
#14
REVIEW
Jemma Longley, Peter W M Johnson
The treatment of advanced classical Hodgkin Lymphoma (cHL) has evolved over the last 50 years with a progressive improvement in long term cure rates in patients up to the age of 60 years. However, a minority of these survivors experience severe morbidity and mortality resulting from intensive chemotherapy and radiotherapy, leading to a drive to de-escalate treatment without compromising survival. The early identification of patients with chemoresistant disease by functional imaging allows the modulation of therapy and an efficient means to test new agents in those most in need of more effective therapy...
November 8, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30408155/mesenchymal-stem-cells-gene-signature-in-high-risk-myeloma-bone-marrow-linked-to-suppression-of-distinct-igfbp2-expressing-small-adipocytes
#15
Syed J Mehdi, Sarah K Johnson, Joshua Epstein, Maurizio Zangari, Pingping Qu, Antje Hoering, Frits van Rhee, Carolina Schinke, Sharmilan Thanendrarajan, Bart Barlogie, Faith E Davies, Gareth J Morgan, Shmuel Yaccoby
Recent studies suggest that multiple myeloma (MM) induces proliferation and expansion of bone marrow (BM) mesenchymal stem cells (MSCs), but others showed that MM cells induce MSC senescence. To clarify the interaction between MM and MSCs, we exploited our established MSC gene signature to identify gene expression changes in myeloma MSCs and associated functional differences. Single MSCs from patients with MM had changes in expression of genes associated with cellular proliferation and senescence and a higher proportion of senescent cells and lower proliferative potential than those from age-matched healthy donors...
November 8, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30408153/myd88-p-l265p-detection-on-cell-free-dna-in-liquid-biopsies-of-patients-with-primary-central-nervous-system-lymphoma
#16
LETTER
Laura S Hiemcke-Jiwa, Roos J Leguit, Tom J Snijders, Jacoline E C Bromberg, Stefan Nierkens, N Mehdi Jiwa, Monique C Minnema, Manon M H Huibers
No abstract text is available yet for this article.
November 8, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30408149/granular-b-lineage-acute-lymphoblastic-leukaemia-mimicking-acute-myeloid-leukaemia
#17
Juan Zhang, Mingyong Li, Yuan He
No abstract text is available yet for this article.
November 8, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30408148/cell-of-origin-in-diffuse-large-b-cell-lymphoma-findings-from-the-uk-s-population-based-haematological-malignancy-research-network
#18
LETTER
Daniel Painter, Sharon Barrans, Stuart Lacy, Alexandra Smith, Simon Crouch, David Westhead, Chulin Sha, Russell Patmore, Reuben Tooze, Cathy Burton, Eve Roman
No abstract text is available yet for this article.
November 8, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30408147/cxcr4-mutations-in-lymphoplasmacytic-lymphoma-lead-to-altered-cxcr4-expression
#19
LETTER
Laura S Hiemcke-Jiwa, Roos J Leguit, N Mehdi Jiwa, Manon M H Huibers, Monique C Minnema
No abstract text is available yet for this article.
November 8, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30408145/the-incidence-of-symptomatic-osteonecrosis-after-allogeneic-haematopoietic-stem-cell-transplantation-in-children-with-acute-lymphoblastic-leukaemia-controversy-on-dexamethasone-as-a-risk-factor
#20
LETTER
Reo Tanoshima, Bruce C Carleton
No abstract text is available yet for this article.
November 8, 2018: British Journal of Haematology
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