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British Journal of Haematology

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https://www.readbyqxmd.com/read/29143319/the-full-spectrum-of-castleman-disease-273-patients-studied-over-20%C3%A2-years
#1
Eric Oksenhendler, David Boutboul, David Fajgenbaum, Adrien Mirouse, Claire Fieschi, Marion Malphettes, Laetitia Vercellino, Véronique Meignin, Laurence Gérard, Lionel Galicier
The spectrum of Castleman disease (CD) has considerably extended since its first description in 1956. Recently, an international collaborative working group has reached consensus on the diagnostic criteria and classification of CD. We herein report 273 patients with lymph node histopathology consistent with CD and investigate the newly established diagnostic criteria. Twenty of these patients with Castleman-like histopathology were removed from analyses, because they were diagnosed with an exclusionary disorder (18 with haematological malignancy)...
November 16, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29143317/castleman-disease-delineating-the-spectrum
#2
EDITORIAL
Musa Alzahrani, Heather A Leitch
No abstract text is available yet for this article.
November 16, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29143315/fetal-haemoglobin-induction-in-sickle-cell-disease
#3
REVIEW
Alireza Paikari, Vivien A Sheehan
Fetal haemoglobin (HbF, α2γ2) induction has long been an area of investigation, as it is known to ameliorate the clinical complications of sickle cell disease (SCD). Progress in identifying novel HbF-inducing strategies has been stymied by limited understanding of gamma (γ)-globin regulation. Genome-wide association studies (GWAS) have identified variants in BCL11A and HBS1L-MYB that are associated with HbF levels. Functional studies have established the roles of BCL11A, MYB, and KLF1 in γ-globin regulation, but this information has not yielded new pharmacological agents...
November 16, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29143312/erythrophagocytosis-by-t-cell-lymphoma-cells-in-a-patient-with-hereditary-spherocytosis-post-splenectomy
#4
Ithiel J Frame, Jared Coberly, Franklin S Fuda, Mingyi Chen
No abstract text is available yet for this article.
November 16, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29143311/interleukin-12-and-its-procoagulant-effect-on-erythrocytes-platelets-and-fibrin-ogen-the-lesser-known-side-of-inflammation
#5
Martin J Page, Janette Bester, Etheresia Pretorius
Inflammation, with its associated inflammatory molecules, is integral to most chronic diseases, including the various cardiovascular diseases. Interleukin 12 (IL12) is one of the inflammatory cytokines that is upregulated during inflammation; however, we know very little about its exact effect on red blood cells (RBCs), platelets and fibrin(ogen). IL12 is an important pleiotropic cytokine in early inflammatory responses and has potent immunomodulatory, antitumour and anti-infection activity. Here we investigate how low levels of circulating IL12, comparable to levels found during chronic inflammation, affect coagulation parameters, platelets and RBCs...
November 16, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29143310/clinical-features-and-outcomes-of-secondary-intraocular-lymphoma
#6
LETTER
Ayako Karakawa, Kazuki Taoka, Toshikatsu Kaburaki, Rie Tanaka, Aya Shinozaki-Ushiku, Hiroyuki Hayashi, Akiko Miyagi-Maeshima, Yu Nishimura, Toshimasa Uekusa, Yui Kojima, Masashi Fukayama, Mineo Kurokawa, Makoto Aihara
No abstract text is available yet for this article.
November 16, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29143308/bone-marrow-dikkopf-1-levels-are-a-new-independent-risk-factor-for-progression-in-patients-with-smouldering-myeloma
#7
LETTER
Benedetta Dalla Palma, Valentina Marchica, Mario Pedrazzoni, Fabrizio Accardi, Laura Notarfranchi, Matteo Goldoni, Federica De Luca, Federica Costa, Paola Storti, Denise Toscani, Gabriella Sammarelli, Sabrina Bonomini, Franco Aversa, Nicola Giuliani
No abstract text is available yet for this article.
November 16, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29143304/inter-individual-variability-in-phospholipid-dependent-interference-of-c-reactive-protein-on-activated-partial-thromboplastin-time
#8
LETTER
Lale Erdem-Eraslan, Jacques J H Hens, André P van Rossum, Marieke A M Frasa, Jeffrey F W Keuren
No abstract text is available yet for this article.
November 16, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29143303/is-food-intolerance-a-factor-underlying-chronic-immune-thrombocytopenia-itp
#9
LETTER
Claire A Batty, John O Hunter, Jenny Woolner, Trevor Baglin, Claire Turner
No abstract text is available yet for this article.
November 16, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29143301/potentially-inappropriate-medication-use-in-elderly-non-hodgkin-lymphoma-patients-is-associated-with-reduced-survival-and-increased-toxicities
#10
Richard J Lin, Helen Ma, Robin Guo, Andrea B Troxel, Catherine S Diefenbach
Survival outcomes for elderly lymphoma patients are disproportionally inferior to those of younger patients. We examined medication usage at diagnosis for 171 elderly patients (median age 70 years) with aggressive non-Hodgkin lymphoma treated between 2009 and 2014. At least one potentially inappropriate medication was used in 47% of patients according to the Beers Criteria, 59% experienced treatment delays and/or dose reduction and 65% experienced ≥ grade 3 treatment-related toxicities. We report here for the first time that potentially inappropriate medication use was associated with reduced progression-free survival and overall survival, and increased ≥ grade 3 treatment-related toxicities in multivariate analysis...
November 16, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29105823/pyridoxine-sensitive-x-linked-sideroblastic-anaemia-in-the-absence-of-ring-sideroblasts-molecular-diagnosis
#11
Thomas Creasey, Tina Biss, John Lambert, Frances Smith, Barnaby Clark, Peter Carey
No abstract text is available yet for this article.
November 5, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29105742/enumeration-and-characterization-of-circulating-multiple-myeloma-cells-in-patients-with-plasma-cell-disorders
#12
Brad Foulk, Mike Schaffer, Steve Gross, Chandra Rao, Denis Smirnov, Mark C Connelly, Shalini Chaturvedi, Manjula Reddy, Greg Brittingham, Marielena Mata, Madeline Repollet, Claudia Rojas, Daniel Auclair, Mary DeRome, Brendan Weiss, Amy K Sasser
We have developed an automated assay to enumerate and characterize circulating multiple myeloma cells (CMMC) from peripheral blood of patients with plasma cell disorders. CMMC show expression of genes characteristic of myeloma and fluorescence in situ hybridisation results on CMMC correlated well with bone marrow results. We enumerated CMMC from over 1000 patient samples including separate cohorts of newly diagnosed multiple myeloma and high/intermediate risk smouldering multiple myeloma (SMM) with clinical follow-up data...
November 5, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29094350/transplant-results-in-adults-with-fanconi-anaemia
#13
Marc Bierings, Carmem Bonfim, Regis Peffault De Latour, Mahmoud Aljurf, Parinda A Mehta, Cora Knol, Farid Boulad, Abdelghani Tbakhi, Albert Esquirol, Grant McQuaker, Gulsan A Sucak, Tarek B Othman, Constantijn J M Halkes, Ben Carpenter, Dietger Niederwieser, Marco Zecca, Nicolaus Kröger, Mauricette Michallet, Antonio M Risitano, Gerhard Ehninger, Raphael Porcher, Carlo Dufour
The outcomes of adult patients transplanted for Fanconi anaemia (FA) have not been well described. We retrospectively analysed 199 adult patients with FA transplanted between 1991 and 2014. Patients were a median of 16 years of age when diagnosed with FA, and underwent transplantation at a median age of 23 years. Time between diagnosis and transplant was shortest (median 2 years) in those patients who had a human leucocyte antigen identical sibling donor. Fifty four percent of patients had bone marrow (BM) failure at transplantation and 46% had clonal disease (34% myelodysplasia, 12% acute leukaemia)...
November 2, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29094334/quantitative-mass-spectrometry-of-human-reticulocytes-reveal-proteome-wide-modifications-during-maturation
#14
Trang T T Chu, Ameya Sinha, Benoit Malleret, Rossarin Suwanarusk, Jung E Park, Renugah Naidu, Rupambika Das, Bamaprasad Dutta, Seow Theng Ong, Navin K Verma, Jerry K Chan, François Nosten, Laurent Rénia, Siu K Sze, Bruce Russell, Rajesh Chandramohanadas
Erythropoiesis is marked by progressive changes in morphological, biochemical and mechanical properties of erythroid precursors to generate red blood cells (RBC). The earliest enucleated forms derived in this process, known as reticulocytes, are multi-lobular and spherical. As reticulocytes mature, they undergo a series of dynamic cytoskeletal re-arrangements and the expulsion of residual organelles, resulting in highly deformable biconcave RBCs (normocytes). To understand the significant, yet neglected proteome-wide changes associated with reticulocyte maturation, we undertook a quantitative proteomics approach...
November 2, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29082516/efficacy-of-biological-agents-in-the-treatment-of-erdheim-chester-disease
#15
LETTER
Gaurav Goyal, Mithun V Shah, Timothy G Call, Mark R Litzow, Alexandra P Wolanskyj-Spinner, Matthew J Koster, W Oliver Tobin, Robert Vassallo, Jay H Ryu, Christopher C Hook, William J Hogan, Ronald S Go
No abstract text is available yet for this article.
October 30, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29082515/a-new-heterozygous-mutation-in-gp1ba-gene-responsible-for-macrothrombocytopenia
#16
LETTER
Dorsaf Ghalloussi, Noémie Saut, Denis Bernot, Xavier Pillois, Philippe Rameau, Gérard Sébahoun, Marie-Christine Alessi, Hana Raslova, Véronique Baccini
No abstract text is available yet for this article.
October 30, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29082513/role-of-99m-tc-dpd-scintigraphy-in-imaging-extra-cardiac-light-chain-al-amyloidosis
#17
LETTER
Sajitha Sachchithanantham, David F Hutt, Ann-Marie Quigley, Philip Hawkins, Ashutosh D Wechalekar
No abstract text is available yet for this article.
October 30, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29082508/optimizing-the-management-of-hereditary-haemochromatosis-the-value-of-mri-r2-quantification-to-predict-and-monitor-body-iron-stores
#18
LETTER
Manuela França, Luis Martí-Bonmatí, Sara Silva, Carla Oliveira, Ángel Alberich Bayarri, Filipa Vilas Boas, Helena Pessegueiro-Miranda, Graça Porto
No abstract text is available yet for this article.
October 30, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29082522/what-is-currently-known-about-the-genetics-of-venous-thromboembolism-at-the-dawn-of-next-generation-sequencing-technologies
#19
REVIEW
David-Alexandre Trégouët, Pierre-Emmanuel Morange
Venous thromboembolism (VTE) has a strong genetic component. This review summarizes what is known at the seventeen genes that are now well established to harbour VTE-associated genetic variants. In addition, it discusses additional candidate genes that deserve further validation before being claimed as VTE associated genes. Finally, several research strategies are briefly described to identify other molecular determinants of the disease.
October 29, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29082519/outcomes-of-adults-and-children-with-primary-mediastinal-b-cell-lymphoma-treated-with-dose-adjusted-epoch-r
#20
Lisa Giulino-Roth, Tara O'Donohue, Zhengming Chen, Nancy L Bartlett, Ann LaCasce, William Martin-Doyle, Matthew J Barth, Kimberly Davies, Kristie A Blum, Beth Christian, Carla Casulo, Sonali M Smith, James Godfrey, Amanda Termuhlen, Matthew J Oberley, Sarah Alexander, Sheila Weitzman, Burton Appel, Benjamin Mizukawa, Jakub Svoboda, Zeinab Afify, Melinda Pauly, Hema Dave, Rebecca Gardner, Deborah M Stephens, William A Zeitler, Christopher Forlenza, Jennifer Levine, Michael E Williams, Jody L Sima, Catherine M Bollard, John P Leonard
Treatment with dose-adjusted EPOCH (etoposide, doxorubicin, cyclophosphamide, vincristine, prednisone) chemotherapy and rituximab (DA-EPOCH-R) has become the standard of care for primary mediastinal B-cell lymphoma (PMBCL) at many institutions despite limited data in the multi-centre setting. We report a large, multi-centre retrospective analysis of children and adults with PMBCL treated with DA-EPOCH-R to characterize outcomes and evaluate prognostic factors. We assessed 156 patients with PMBCL treated with DA-EPOCH-R across 24 academic centres, including 38 children and 118 adults...
October 29, 2017: British Journal of Haematology
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