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British Journal of Haematology

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https://www.readbyqxmd.com/read/28211581/analysis-of-high-resolution-human-leucocyte-antigen-allele-polymorphism-in-3788-han-chinese-patients-with-leukaemia
#1
LETTER
Kuanzhen Liao, Zhongzheng Zheng, Lan Yang, Liping Wang, Ningjuan Wang, Lirong Zhang, Jie Pan, Keming Du, Ying Hu, Jinwei Du, Hongyan Chen
No abstract text is available yet for this article.
February 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28211579/impact-of-treatment-variability-on-survival-in-immuno-competent-and-immuno-compromised-patients-with-primary-central-nervous-lymphoma
#2
Reem Karmali, Chadi Nabhan, Adam M Petrich, Jeffrey Raizer, David Peace, Rimas Lukas, Leo I Gordon, Sanjib Basu, Vineela Chukkapalli, Parameswaran Venugopal
Patients with primary central nervous system lymphoma (PCNSL) treated in the 'real-world' setting do not represent those treated on clinical trials and might not be treated similarly. We studied characteristics and variability in care for 113 newly diagnosed PCNSL patients treated at 5 institutions in the Chicago area between 2000 and 2012. In 111 patients, single modality therapy with a high dose methotrexate (HD-MTX) regimen +/- rituximab, was most commonly employed (n = 65), and 34 underwent radiotherapy (+/- systemic therapy)...
February 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28211578/myeloid-sarcoma-arising-in-malignant-phyllodes-tumour-clonal-relationships-revealed-by-comparative-genome-wide-analyses
#3
LETTER
Hideo Arai, Sumihito Nobusawa, Reika Kawabata-Iwakawa, Susumu Rokudai, Toru Higuchi, Tatsuya Yamazaki, Jun Horiguchi, Takaaki Sano, Masaru Kojima, Masahiko Nishiyama, Hideaki Yokoo, Junko Hirato, Tetsunari Oyama
No abstract text is available yet for this article.
February 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28211574/conditioning-regimens-for-autologous-haematopoietic-stem-cell-transplantation-can-natural-killer-cell-therapy-help
#4
EDITORIAL
John A Snowden, Geoffrey R Hill
No abstract text is available yet for this article.
February 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28211573/the-cationic-small-molecule-gw4869-is-cytotoxic-to-high-phosphatidylserine-expressing-myeloma-cells
#5
Slavica Vuckovic, Kate Vandyke, David A Rickards, Padraig McCauley Winter, Simon H J Brown, Todd W Mitchell, Jun Liu, Jun Lu, Philip W Askenase, Elizabeth Yuriev, Ben Capuano, Paul A Ramsland, Geoffrey R Hill, Andrew C W Zannettino, Andrew T Hutchinson
We have discovered that a small cationic molecule, GW4869, is cytotoxic to a subset of myeloma cell lines and primary myeloma plasma cells. Biochemical analysis revealed that GW4869 binds to anionic phospholipids such as phosphatidylserine - a lipid normally confined to the intracellular side of the cell membrane. However, interestingly, phosphatidylserine was expressed on the surface of all myeloma cell lines tested (n = 12) and 9/15 primary myeloma samples. Notably, the level of phosphatidylserine expression correlated well with sensitivity to GW4869...
February 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28211570/platelet-phagocytosis-by-granulopoietic-precursors-in-a-myelodysplastic-syndrome-overexpressing-the-p-selectin-gene
#6
Rosario M Morales-Camacho, M Dolores Serrano-Chacón, Concepción Prats-Martín, M Teresa Vargas, Ricardo Bernal, Sergio Burillo-Sanz
No abstract text is available yet for this article.
February 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28211569/microcytic-anaemias-in-childhood-and-iron-refractory-iron-deficiency-anaemia
#7
EDITORIAL
Martin J Pippard
No abstract text is available yet for this article.
February 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28211568/targeted-therapies-for-t-cell-acute-lymphoblastic-leukaemia-t-all-what-makes-t-all-tyk
#8
EDITORIAL
David J Curtis
No abstract text is available yet for this article.
February 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28211564/the-genomics-of-inherited-bone-marrow-failure-from-mechanism-to-the-clinic
#9
REVIEW
Talia Wegman-Ostrosky, Sharon A Savage
The inherited bone marrow failure syndromes (IBMFS) typically present with significant cytopenias in at least one haematopoietic cell lineage that may progress to pancytopenia, and are associated with increased risk of cancer. Although the clinical features of the IBMFS are often diagnostic, variable disease penetrance and expressivity may result in diagnostic dilemmas. The discovery of the genetic aetiology of the IBMFS has been greatly facilitated by next-generation sequencing methods. This has advanced understanding of the underlying biology of the IBMFS and been essential in improving clinical management and genetic counselling for affected patients...
February 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28211562/long-term-impact-of-molecular-response-fluctuations-in-chronic-myeloid-leukaemia-patients-treated-with-imatinib
#10
LETTER
Matteo Molica, Massimo Breccia, Gioia Colafigli, Fulvio Massaro, Luisa Quattrocchi, Marco Mancini, Daniela Diverio, Roberto Latagliata, Robin Foà
No abstract text is available yet for this article.
February 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28211560/carfilzomib-lenalidomide-and-dexamethasone-in-patients-with-relapsed-multiple-myeloma-categorised-by-age-secondary-analysis-from-the-phase-3-aspire-study
#11
Meletios A Dimopoulos, A Keith Stewart, Tamás Masszi, Ivan Špička, Albert Oriol, Roman Hájek, Laura Rosiñol, David Siegel, Georgi G Mihaylov, Vesselina Goranova-Marinova, Péter Rajnics, Aleksandr Suvorov, Ruben Niesvizky, Andrzej Jakubowiak, Jesus San-Miguel, Heinz Ludwig, Antonio Palumbo, Mihaela Obreja, Sanjay Aggarwal, Philippe Moreau
: A primary analysis of the ASPIRE study found that the addition of carfilzomib to lenalidomide and dexamethasone (carfilzomib group) significantly improved progression-free survival (PFS) compared with lenalidomide and dexamethasone alone (control group) in patients with relapsed multiple myeloma (RMM). This post hoc analysis examined outcomes from ASPIRE in patients categorised by age. In the carfilzomib group, 103/396 patients were ≥70 years old, and in the control group, 115/396 patients were ≥70 years old...
February 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28211054/real-world-use-of-pomalidomide-and-dexamethasone-in-double-refractory-multiple-myeloma-suggests-benefit-in-renal-impairment-and-adverse-genetics-a-multi-centre-uk-experience
#12
Nicola Maciocia, Andrew Melville, Simon Cheesman, Faye Sharpley, Karthik Ramasamy, Matthew Streetly, Matthew Jenner, Reuben Benjamin, Steve Schey, Paul Maciocia, Rakesh Popat, Shirley D'sa, Ali Rismani, Aviva Cerner, Kwee Yong, Neil Rabin
Myeloma patients who become refractory to immunomodulatory agents (IMiDs) and bortezomib have poor survival, with limited therapeutic options. Pomalidomide has shown improved survival and good tolerability in this patient cohort in clinical trials, but real world data are scarce. We retrospectively analysed all patients treated with pomalidomide at five UK centres between 2013 and 2016. Of 85 patients identified, 70 had sufficient information for response assessments. Median age was 66 years [40-89], 96·5% were refractory to IMiDs, 72·9% were refractory to both an IMiD and bortezomib and 92·9% were refractory to their last treatment...
February 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28211051/antibiotic-use-associated-with-vte-and-its-implications-a-new-trigger-for-thromboprophylaxis-and-for-reclassification-of-some-unprovoked-to-provoked-vte-s
#13
EDITORIAL
Jürg H Beer
No abstract text is available yet for this article.
February 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28211044/antibiotic-use-as-a-marker-of-acute-infection-and-risk-of-first-and-recurrent-venous-thrombosis
#14
Jasmijn F Timp, Suzanne C Cannegieter, Vladimir Tichelaar, Sigrid K Braekkan, Frits R Rosendaal, Saskia le Cessie, Willem M Lijfering
A role for transient infections in the aetiology of venous thrombosis (VT) has been suggested. This study aimed to determine whether individuals who receive antibiotic treatment (as a proxy for infections) have an increased risk of first and recurrent VT and whether infections should be seen as a provoking risk factor for VT. We used the self-controlled case series method to study the risk of first VT during antibiotic prescriptions. The risk of recurrent VT during antibiotic use was estimated by of time-dependent Cox-regression...
February 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28211042/renal-failure-in-multiple-myeloma-something-new-on-the-horizon
#15
EDITORIAL
Massimo Offidani, Laura Corvatta
No abstract text is available yet for this article.
February 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28198999/investigation-and-management-of-igm-and-waldenstr%C3%A3-m-associated-peripheral-neuropathies-recommendations-from-the-iwwm-8-consensus-panel
#16
LETTER
Shirley D'Sa, Marie José Kersten, Jorge J Castillo, Meletios Dimopoulos, Efstathios Kastritis, Edward Laane, Véronique Leblond, Giampaolo Merlini, Steven P Treon, Josephine M Vos, Michael P Lunn
Paraproteinaemic neuropathies are a heterogeneous group of disorders most frequently associated with IgM monoclonal gammopathies including Waldenström macroglobulinaemia (WM). Their consequences are significant for affected patients, and their management challenging for their physicians. The variability in clinical presentation and time course hamper classification and management. The indications for invasive investigations such as cerebrospinal fluid analysis, nerve conduction tests and sensory nerve biopsies are unclear, and the optimum way to measure clinical response to treatment unknown...
February 15, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28198996/treatment-burden-haemostatic-strategies-and-real-world-inhibitor-screening-practice-in-non-severe-haemophilia-a
#17
Paul Batty, Steve K Austin, Kate Khair, Carolyn M Millar, Ben Palmer, Savita Rangarajan, Jan-Phillip Stümpel, Murugaiyan Thanigaikumar, Thynn T Yee, Daniel P Hart
Inhibitor formation in non-severe haemophilia A is a life-long risk and associated with morbidity and mortality. There is a paucity of data to understand real-world inhibitor screening practice. We evaluated the treatment burden, haemostatic strategies, F8 genotyping and inhibitor screening practices in non-severe haemophilia A in seven London haemophilia centres. In the 2-year study period, 44% (377/853) patients received at least one haemostatic treatment. Seventy-nine percent of those treated (296/377) received factor VIII (FVIII) concentrate...
February 15, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28198001/lymphoma-cell-of-origin-assignment-by-gene-expression-profiling-is-clinically-meaningful-across-broad-laboratory-contexts
#18
LETTER
Grace Gifford, Sara Gabrielli, Anthony Gill, Matthew Greenwood, Kelly Wong, Giles Best, David Nevell, Kirsty McIlroy, David Kliman, Louise Ilmay-Gillespie, Campbell Tiley, Sunaina Miranda, Tasman Armytage, William Stevenson
No abstract text is available yet for this article.
February 15, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28197996/upfront-lower-dose-lenalidomide-is-less-toxic-and-does-not-compromise-efficacy-for-vulnerable-patients-with-relapsed-refractory-multiple-myeloma-final-analysis-of-the-phase-ii-revlite-study
#19
Hang Quach, Liam Fernyhough, Ross Henderson, Gillian Corbett, Bart Baker, Peter Browett, Hilary Blacklock, Cecily Forsyth, Craig Underhill, Paul Cannell, Judith Trotman, Annette Neylon, Simon Harrison, Emma Link, Arlene Swern, Linda Cowan, Meletios A Dimopoulos, H Miles Prince
The combination of lenalidomide and dexamethasone is an established treatment for patients with multiple myeloma (MM). Increasingly, treatment attenuation is advocated for frail/elderly patients to minimize toxicity even though there have been no prospective studies to demonstrate whether lenalidomide dose attenuation impacts on response and survival outcome. This prospective multicentre phase II study assessed the efficacy and tolerability of lower dose lenalidomide (15 mg) and dexamethasone (20 mg) in 149 eligible patients with relapsed/refractory MM aged over 59 years and/or with renal impairment...
February 15, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28182257/inhibitor-screening-in-non-severe-haemophilia-patients-a-major-challenge
#20
EDITORIAL
Anne-Mette Hvas, Lone H Poulsen
No abstract text is available yet for this article.
February 9, 2017: British Journal of Haematology
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