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British Journal of Haematology

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https://www.readbyqxmd.com/read/28542862/subsequent-primary-malignancies-after-diffuse-large-b-cell-lymphoma-in-the-modern-treatment-era
#1
Li Tao, Christina A Clarke, Aaron S Rosenberg, Ranjana H Advani, Brian A Jonas, Christopher R Flowers, Theresa H M Keegan
With the addition of rituximab and other treatment advances, survival after diffuse large B-cell lymphoma (DLBCL) has improved, but subsequent primary malignancies (SPMs) have emerged as an important challenge for DLBCL survivorship. We calculated standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) for SPMs among 23 879 patients who survived at least 1 year after a first primary DLBCL diagnosed during 1989-2012, compared to the general population in California. Cumulative incidence (CMI) of SPMs, accounting for the competing risk of death, also was calculated...
May 25, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28542835/subcutaneous-rituximab-can-be-safely-administered-without-pre-medication
#2
LETTER
Samuel H Burrows, Oluwatosin Akinbobuyi, Simon Rule, Nicola Crosbie
No abstract text is available yet for this article.
May 25, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28542787/understanding-the-reconstitution-of-the-b-cell-compartment-in-bone-marrow-and-blood-after-treatment-for-b-cell-precursor-acute-lymphoblastic-leukaemia
#3
Prisca M J Theunissen, Anouk van den Branden, Alita Van Der Sluijs-Gelling, Valerie De Haas, Auke Beishuizen, Jacques J M van Dongen, Vincent H J Van Der Velden
A better understanding of the reconstitution of the B-cell compartment during and after treatment in B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) will help to assess the immunological status and needs of post-treatment BCP-ALL patients. Using 8-colour flow cytometry and proliferation-assays, we studied the composition and proliferation of both the B-cell precursor (BCP) population in the bone marrow (BM) and mature B-cell population in peripheral blood (PB) during and after BCP-ALL therapy. We found a normal BCP differentiation pattern and a delayed formation of classical CD38(dim) -naive mature B-cells, natural effector B-cells and memory B-cells in patients after chemotherapy...
May 25, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28542715/hyperleucocytosis-in-paediatric-acute-myeloid-leukaemia-the-challenge-of-white-blood-cell-counts-above-200%C3%A2-%C3%A3-%C3%A2-10-9-l-the-nopho-experience-1984-2014
#4
Bernward Zeller, Heidi Glosli, Erik Forestier, Shau-Yin Ha, Kirsi Jahnukainen, Ólafur G Jónsson, Birgitte Lausen, Josefine Palle, Henrik Hasle, Jonas Abrahamsson
Hyperleucocytosis in paediatric acute myeloid leukaemia (AML) is associated with increased morbidity and mortality. We studied hyperleucocytosis in 890 patients with AML aged 0-18 years registered in the Nordic Society of Paediatric Haematology and Oncology (NOPHO) registry, with special focus on very high white blood cell counts (WBC >200 × 10/l). Eighty-six patients (10%) had WBC 100-199 × 10(9) /l and 57 (6%) had WBC ≥200 × 10(9) /l. Patients with WBC ≥200 × 10(9) /l had a high frequency of t(9;11) and a paucity of trisomy 8...
May 25, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28543061/serum-ferritin-in-the-diagnosis-of-cardiac-and-liver-iron-overload-in-thalassaemia-patients-real-world-practice-a-multicentre-study
#5
LETTER
Rungroj Krittayaphong, Vip Viprakasit, Pairash Saiviroonporn, Wipaporn Wangworatrakul, John C Wood
No abstract text is available yet for this article.
May 23, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28542907/british-committee-for-standards-in-haematology-guidelines-for-aplastic-anemia-single-centre-retrospective-review-finds-no-compelling-evidence-for-the-recommended-higher-platelet-count-threshold-of-20%C3%A2-%C3%A3-%C3%A2-10-9-l-response-to-yan-et%C3%A2-al
#6
LETTER
Sally B Killick, Nick Bown, Jamie Cavenagh, Inderjeet Dokal, Theodora Foukaneli, Peter Hillmen, Robin Ireland, Austin Kulasekararaj, Ghulam Mufti, John A Snowden, Sujith Samarasinghe, Anna Wood, Judith C W Marsh
No abstract text is available yet for this article.
May 23, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28542840/role-of-nox2-for-leukaemic-expansion-in-a-murine-model-of-bcr-abl1-leukaemia
#7
LETTER
Hanna Grauers Wiktorin, Tina Nilsson, Ebru Aydin, Kristoffer Hellstrand, Lars Palmqvist, Anna Martner
No abstract text is available yet for this article.
May 23, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28542830/wilms-tumour-1-peptide-vaccine-as-a-cure-oriented-post-chemotherapy-strategy-for-patients-with-acute-myeloid-leukaemia-at-high-risk-of-relapse
#8
LETTER
Jun Nakata, Yoshiki Nakae, Manabu Kawakami, Soyoko Morimoto, Daisuke Motooka, Naoki Hosen, Fumihiro Fujiki, Hiroko Nakajima, Kana Hasegawa, Sumiyuki Nishida, Akihiro Tsuboi, Yusuke Oji, Yoshihiro Oka, Atsushi Kumanogoh, Haruo Sugiyama
No abstract text is available yet for this article.
May 23, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28542814/gpiib-iiia-autoantibody-predicts-better-rituximab-response-in-itp
#9
LETTER
Rui Feng, Xinguang Liu, Yajing Zhao, Yuanyuan Zhu, Jun Peng, Ming Hou, Chunyan Chen
No abstract text is available yet for this article.
May 23, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28542795/interleukin-6-g-174c-polymorphism-predicts-higher-risk-of-stroke-in-sickle-cell-anaemia
#10
LETTER
Igor F Domingos, Diego A Pereira-Martins, Juan L Coelho-Silva, Rayssa L Borges-Medeiros, Diego A Falcão, Renata C Azevedo, Ana C Anjos, Fernando F Costa, Taciana F Mendonça, Maria S Cavalcanti, Aderson S Araujo, Antonio R Lucena-Araujo, Marcos A Bezerra
No abstract text is available yet for this article.
May 23, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28542789/annotation-developing-a-national-programme-for-vte-prevention
#11
Lara N Roberts, Mike Durkin, Roopen Arya
The National Venous Thromboembolism Prevention Programme was launched in England, in 2010. Its central objective was to reduce morbidity and mortality from preventable deep vein thrombosis and pulmonary embolism through introduction of a comprehensive systematic approach. The cornerstone of the programme was the introduction of mandatory documented risk assessment for venous thromboembolism, supported by national thromboprophylaxis guidance. Despite widespread uptake of risk assessment, measuring the impact of the national programme on outcomes has proved challenging...
May 23, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28542728/hypomegakaryocytic-thrombocytopenia-and-increased-number-of-pnh-phenotype-cells-an-emerging-subgroup-of-myelodysplastic-syndrome-showing-frequent-response-to-immunosuppression
#12
LETTER
Mark Rafferty, Mike Leach
No abstract text is available yet for this article.
May 23, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28542718/impact-of-genotype-on-leukaemic-transformation-in-polycythaemia-vera-and-essential-thrombocythaemia
#13
Alberto Alvarez-Larrán, Alicia Senín, Concepción Fernández-Rodríguez, Arturo Pereira, Eduardo Arellano-Rodrigo, Montse Gómez, Francisca Ferrer-Marin, Joaquín Martínez-López, Laura Camacho, Dolors Colomer, Anna Angona, Blanca Navarro, Francisco Cervantes, Carlos Besses, Beatriz Bellosillo, Juan Carlos Hernández-Boluda
The influence of driver mutations on leukaemic transformation was analysed in 1747 patients with polycythaemia vera or essential thrombocythaemia. With a median follow-up of 7·2 years, 349 patients died and 62 progressed to acute leukaemia or myelodysplastic syndrome. Taking death as a competing risk, CALR genotype was associated with a lower risk of transformation [subdistribution hazard ratio (SHR): 0·13, 95% confidence interval (CI): 0·2-0·9, P = 0·039], whereas JAK2 V617F showed borderline significance for higher risk (SHR: 2·05, 95% CI: 0·9-4·6, P = 0·09)...
May 23, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28542714/real-world-data-on-rituximab-maintenance-therapy-after-frontline-immunochemotherapy-in-grade-1-3a-follicular-lymphoma
#14
LETTER
Rie S Bech, Kasper L Nielsen, Thomas S Larsen, Hans H Bentzen, Line S Lynggaard, Trung H Do, Peter Braendstrup, Jessica Brady, N George Mikhaeel, Karen Dybkaer, Hans E Johnsen, Paw Jensen, Martin Bøgsted, Tarec C El-Galaly
No abstract text is available yet for this article.
May 23, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28542711/preventing-relapse-after-haematopoietic-stem-cell-transplantation-for-acute-leukaemia-the-role-of-post-transplantation-minimal-residual-disease-mrd-monitoring-and-mrd-directed-intervention
#15
REVIEW
Xiao-Dong Mo, Meng Lv, Xiao-Jun Huang
Relapse is the main cause of treatment failure after allogeneic haematopoietic stem cell transplantation (allo-HSCT) for acute leukaemia (AL). Post-transplantation minimal residual disease (MRD) monitoring enables risk stratification and identifies AL patients at higher risk of relapse. MRD assessment primarily involves the determination of leukaemia-associated immunophenotypic patterns using multiparameter flow cytometry, and the polymerase chain reaction (PCR)-based evaluation of expression levels of leukaemia-related genes (specific reciprocal gene rearrangements and other mutation types)...
May 23, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28543173/a-clinical-review-of-communication-training-for-haematologists-and-haemato-oncologists-a-case-of-art-versus-science
#16
REVIEW
Deborah Christie, Sarah Glew
The art of communication at times seems at odds with the science of medicine. Poor communication is associated with risks for patient and physician. Communication skills are highly relevant for haematologists and are associated with increased physician and patient satisfaction, positive psychosocial outcomes and possible health outcomes. Medical communication training has recently become widespread but is largely restricted to junior medical professionals. In haematology, the proliferation of high quality communication skills is low and there are few interventions catering for the required skillset...
May 22, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28542841/blood-donors-perceptions-motivators-and-deterrents-in-sub-saharan-africa-a-scoping-review-of-evidence
#17
REVIEW
Lucy Asamoah-Akuoko, Oliver W Hassall, Imelda Bates, Henrik Ullum
Achieving an adequate blood supply in Sub-Saharan Africa (SSA) through donor mobilization and retention is crucial. Factors that motivate or deter blood donors vary according to beliefs and social norms. Understanding the factors that influence blood donation behaviour in SSA is vital to developing effective strategies to address blood donor motivation and retention. This review of 35 studies from 16 SSA countries collates available evidence concerning the perceptions, motivators and deterrents that influence blood donors in SSA...
May 22, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28516484/incidental-finding-of-recent-parvovirus-infection
#18
Elaine Leung, Eileen McBride
No abstract text is available yet for this article.
May 18, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28516512/defective-%C3%AE-2-antiplasmin-cross-linking-and-thrombus-stability-in-a-case-of-acquired-factor-xiii-deficiency
#19
Joanne L Mitchell, Sonja Wright, Sajida Kazi, Henry G Watson, Nicola J Mutch
Acquired factor XIII (FXIII) deficiency is a rare and life-threatening condition that is often misdiagnosed or missed completely. A 72-year-old woman presented with symptoms of major unprovoked bleeding but routine coagulation screening tests and platelet count were normal. Low activated FXIII (FXIIIa) activity levels and abnormal urea clot stability led to diagnosis of acquired FXIII deficiency. A modified Bethesda inhibitor titre of 1.6 Bethesda units/ml indicated the presence of a FXIII inhibitor. Bleeding responded to a single dose of FXIII concentrate and immunosuppression with prednisolone induced remission...
May 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28516501/the-histone-acetyltranseferase-kat8-regulates-cell-differentiation-by-suppression-of-mn1-in-aml
#20
LETTER
Wen-Bo Zhao, Meng Wang, Shuang Gao, Abdul S Shaikh, Jianmei Chen, Xiang-Zhi Li
No abstract text is available yet for this article.
May 17, 2017: British Journal of Haematology
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