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British Journal of Haematology

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https://www.readbyqxmd.com/read/28804905/the-evolution-of-paroxysmal-nocturnal-haemoglobinuria-depends-on-intensity-of-immunosuppressive-therapy
#1
LETTER
Taha Bat, Omnia N Abdelhamid, Suresh K Balasubramanian, Aly Mai, Tomas Radivoyevitch, Michael Clemente, Jaroslaw P Maciejewski
No abstract text is available yet for this article.
August 14, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28786474/dexamethasone-rituximab-and-cyclophosphamide-for-relapsed%C3%A2-and-or-refractory-and-treatment-na%C3%A3-ve-patients-with-waldenstrom-macroglobulinemia
#2
Jonas Paludo, Jithma P Abeykoon, Shaji Kumar, Amanda Shreders, Sikander Ailawadhi, Morie A Gertz, Taxiarchis Kourelis, Rebecca L King, Craig B Reeder, Nelson Leung, Robert A Kyle, Francis K Buadi, Thomas M Habermann, David Dingli, Thomas E Witzig, Angela Dispenzieri, Martha Q Lacy, Ronald S Go, Yi Lin, Wilson I Gonsalves, Rahma Warsame, John A Lust, S Vincent Rajkumar, Stephen M Ansell, Prashant Kapoor
The management of Waldenström macroglobulinaemia (WM) relies predominantly on small trials, one of which has demonstrated activity of dexamethasone, rituximab and cyclophosphamide (DRC) in the frontline setting. We report on the efficacy of DRC, focusing on relapsed/refractory (R/R) patients. Ibrutinib, a recently approved agent in WM demonstrated limited activity in patients with MYD88(WT) genotype. Herein, we additionally report on the activity of DRC based on the MYD88(L265P) mutation status. Of 100 WM patients evaluated between January 2007 and December 2014 who received DRC, 50 had R/R WM...
August 8, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28782811/risk-of-and-survival-following-histological-transformation-in-follicular-lymphoma-in-the-rituximab-era-a-retrospective-multicentre-study-by-the-spanish-geltamo-group
#3
Sara Alonso-Álvarez, Laura Magnano, Miguel Alcoceba, Marcio Andrade-Campos, Natalia Espinosa-Lara, Guillermo Rodríguez, Santiago Mercadal, Itziar Carro, Juan M Sancho, Miriam Moreno, Antonio Salar, Francesc García-Pallarols, Reyes Arranz, Jimena Cannata, María José Terol, Ana I Teruel, Antonia Rodríguez, Ana Jiménez-Ubieto, Sonia González de Villambrosia, José L Bello, Lourdes López, Silvia Monsalvo, Silvana Novelli, Erik de Cabo, María S Infante, Emilia Pardal, María García-Álvarez, Julio Delgado, Marcos González, Alejandro Martín, Armando López-Guillermo, María D Caballero
The diagnostic criteria for follicular lymphoma (FL) transformation vary among the largest series, which commonly exclude histologically-documented transformation (HT) mandatorily. The aims of this retrospective observational multicentre study by the Spanish Grupo Español de Linfoma y Transplante Autólogo de Médula Ósea, which recruited 1734 patients (800 males/934 females; median age 59 years), diagnosed with FL grades 1-3A, were, (i) the cumulative incidence of HT (CI-HT); (ii) risk factors associated with HT; and (iii) the role of treatment and response on survival following transformation (SFT)...
August 7, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28771685/paradoxical-activation-of-alternative-pro-survival-pathways-determines-resistance-to-mek-inhibitors-in-chronic-lymphocytic-leukaemia
#4
LETTER
Yixiang Chen, Sandra Germano, Ghalia Shelmani, Diana Kluczna, Sandrine Jayne, Martin J S Dyer, Salvador Macip
No abstract text is available yet for this article.
August 2, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28771682/development-of-artificial-bone-marrow-fibre-scaffolds-to-study-resistance-to-anti-leukaemia-agents
#5
LETTER
Mahroo Karimpoor, Eranka IIlangakoon, Alistair G Reid, Simone Claudiani, Mohan Edirisinghe, Jamshid S Khorashad
No abstract text is available yet for this article.
August 2, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28771681/whole-genome-mbd-seq-reveals-different-cpg-methylation-patterns-in-azacytidine-treated-juvenile-myelomonocytic-leukaemia-jmml-patients
#6
LETTER
Pier Paolo Leoncini, Patrizia Vitullo, Francesca Di Florio, Valeria Tocco, Maria Giuseppina Cefalo, Angela Pitisci, Katia Girardi, Charlotte Niemeyer, Franco Locatelli, Alice Bertaina
No abstract text is available yet for this article.
August 2, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28771676/allogeneic-haematopoietic-cell-transplantation-for-extranodal-natural-killer-t-cell-lymphoma-nasal-type-a-cibmtr-analysis
#7
LETTER
Abraham S Kanate, Alyssa DiGilio, Kwang W Ahn, Monzr Al Malki, Eric Jacobsen, Amir Steinberg, Nelson Hamerschlak, Mohamed Kharfan-Dabaja, Rachel Salit, Edward Ball, Qaiser Bashir, Amanda Cashen, Daniel Couriel, Jose Diez-Martin, Emmanuel Katsanis, Yulia Linhares, Shahram Mori, Richard Nash, Attaphol Pawarode, Miguel-Angel Perales, Colin D Phipps, Carol Richman, Bipin N Savani, Michael Y Shapira, Patrick Stiff, Roger Strair, Timothy S Fenske, Sonali M Smith, Anna Sureda, Horatiu Olteanu, Mehdi Hamadani
No abstract text is available yet for this article.
August 2, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28771675/clinicopathological-characteristics-outcomes-and-pattern-of-mutations-in-patients-with-follicular-lymphoma-who-progressed-on-bruton-tyrosine-kinase-inhibitors
#8
LETTER
Preetesh Jain, Rashmi Kanagal-Shamanna, F Anthony San Lucas, Loretta Nastoupil, Jorge Romaguera, Luis Fayad, Yasuhiro Oki, Jason R Westin, Leonard Jeffrey Medeiros, Michael Wang, Nathan Fowler
No abstract text is available yet for this article.
August 2, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28771673/activity-of-lenalidomide-in-mantle-cell-lymphoma-can-be-explained-by-nk-cell-mediated-cytotoxicity
#9
Patrick R Hagner, Hsiling Chiu, Maria Ortiz, Benedetta Apollonio, Maria Wang, Suzana Couto, Michelle F Waldman, Erin Flynt, Alan G Ramsay, Matthew Trotter, Anita K Gandhi, Rajesh Chopra, Anjan Thakurta
Lenalidomide is an immunomodulatory agent that has demonstrated clinical benefit for patients with relapsed or refractory mantle cell lymphoma (MCL); however, despite this observed clinical activity, the mechanism of action (MOA) of lenalidomide has not been characterized in this setting. We investigated the MOA of lenalidomide in clinical samples from patients enrolled in the CC-5013-MCL-002 trial (NCT00875667) comparing single-agent lenalidomide versus investigator's choice single-agent therapy and validated our findings in pre-clinical models of MCL...
August 2, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28771672/med12-mutations-and-notch-signalling-in-chronic-lymphocytic-leukaemia
#10
Bian Wu, Mikołaj Słabicki, Leopold Sellner, Sascha Dietrich, Xiyang Liu, Alexander Jethwa, Jennifer Hüllein, Tatjana Walther, Lena Wagner, Zhiqin Huang, Marc Zapatka, Thorsten Zenz
Mutations in the N-terminus of MED12 protein occur at high frequency in uterine leiomyomas and breast fibroepithelial tumours, and are frequently found in chronic lymphocytic leukaemia (CLL). MED12 mutations have been previously linked to aberrant Cyclin C-CDK8 kinase activity, but the exact oncogenic function in CLL is unknown. Here, we characterized MED12 mutations in CLL and identified recurrent mutations in 13 out of 188 CLL patients (6·9%), which clustered in the N-terminus. MED12 mutations were associated with unmutated IGHV (P = 0·024)...
August 2, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28771671/assessment-of-the-efficacy-of-a-novel-tailored-vitamin-k-dosing-regimen-in-lowering-the-international-normalised-ratio-in-over-anticoagulated-patients-a-randomised-clinical-trial
#11
Emmanouela Kampouraki, Peter J Avery, Hilary Wynne, Tina Biss, John Hanley, Kate Talks, Farhad Kamali
Current guidelines advocate using fixed-doses of oral vitamin K to reverse excessive anticoagulation in warfarinised patients who are either asymptomatic or have minor bleeds. Over-anticoagulated patients present with a wide range of International Normalised Ratio (INR) values and response to fixed doses of vitamin K varies. Consequently a significant proportion of patients remain outside their target INR after vitamin K administration, making them prone to either haemorrhage or thromboembolism. We compared the performance of a novel tailored vitamin K dosing regimen to that of a fixed-dose regimen with the primary measure being the proportion of over-anticoagulated patients returning to their target INR within 24 h...
August 2, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28771670/clarithromycin-as-a-repurposing-drug-against-malt-lymphoma
#12
LETTER
Andrés J M Ferreri, Caterina Cecchetti, Barbara Kiesewetter, Marianna Sassone, Teresa Calimeri, Salvatore Perrone, Maurilio Ponzoni, Markus Raderer
No abstract text is available yet for this article.
August 2, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28771666/how-i-manage-sickle-cell-patients-with-high-transcranial-doppler-results
#13
REVIEW
John Brewin, Banu Kaya, Subarna Chakravorty
Stroke is one of the most severe complications to affect children with sickle cell anaemia (SCA). Transcranial doppler (TCD) is an accurate and non-invasive method to determine stroke risk. Randomised controlled trials have demonstrated the efficacy of chronic transfusion therapy in stroke prevention based on risk stratification determined by TCD velocities. This has led to the regular use of TCD monitoring for children with SCA in order to determine stroke risk. Significant resource allocation is necessary to facilitate training, quality assurance and failsafe arrangements for non-attenders...
August 2, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28771663/safety-and-efficacy-of-nelarabine-in-children-and-young-adults-with-relapsed-or-refractory-t-lineage-acute-lymphoblastic-leukaemia-or-t-lineage-lymphoblastic-lymphoma-results-of-a-phase-4-study
#14
Christian Michel Zwaan, Jerzy Kowalczyk, Claudine Schmitt, Bella Bielorai, Mark W Russo, Mary Woessner, Sulabha Ranganathan, Guy Leverger
Nelarabine is an antineoplastic agent approved for the treatment of relapsed/refractory T-lineage acute lymphoblastic leukaemia (T-ALL) or T-lineage acute lymphoblastic lymphoma (T-LBL). The purpose of this phase 4, multicentre, single-arm, observational, open-label trial was to provide additional data on the safety and efficacy of nelarabine under licensed conditions of use in children and young adults ≤21 years of age. Patients (N = 28) had a mean ± standard deviation age of 11·5 ± 4·6 years; 71% were male and 61% had a diagnosis of T-ALL...
August 2, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28771662/neurotoxic-side-effects-in-children-with-refractory-or-relapsed-t-cell-malignancies-treated-with-nelarabine-based-therapy
#15
Michaela Kuhlen, Kirsten Bleckmann, Anja Möricke, Martin Schrappe, Simon Vieth, Gabriele Escherich, Annika Bronsema, Annika Vonalt, Manon Queudeville, C Michel Zwaan, Martin Ebinger, Klaus-Michael Debatin, Thomas Klingebiel, Ewa Koscielniak, Claudia Rossig, Birgit Burkhardt, Reinhard Kolb, Cornelia Eckert, Arndt Borkhardt, Arend von Stackelberg, Christiane Chen-Santel
The prognosis in children with refractory or relapsed (r/r) T-cell acute lymphoblastic leukaemia (T-ALL) or lymphoblastic lymphoma (T-LBL) is poor. Nelarabine (Ara-G) has successfully been used as salvage therapy in these children, but has been associated with significant, even fatal, neurotoxicities. We retrospectively analysed 52 patients with r/r T-ALL/T-LBL aged ≤19 years who were treated with Ara-G alone (n = 25) or in combination with cyclophosphamide and etoposide (n = 27). The majority of patients (45/52) received 1-2 cycles of Ara-G...
August 2, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28771661/hoodwinking-the-analyser-malaria-parasites-and-fluorescent-platelet-enumeration
#16
Swati Pai, Rekha Bhat
No abstract text is available yet for this article.
August 2, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28771660/international-variations-in-the-use-of-haematopoietic-cell-transplantation-for-haematological-malignancies-the-effects-of-national-transplant-indications-tables-and-differing-access-to-therapies
#17
EDITORIAL
Rachel E Protheroe, Jennifer M Bird, David I Marks
No abstract text is available yet for this article.
August 2, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28771659/excellent-outcome-with-limited-treatment-in-paediatric-patients-with-marginal-zone-lymphoma
#18
LETTER
Olga Makarova, Ilske Oschlies, Stephanie Müller, Stephanie Ruf, Martin Zimmermann, Felix Niggli, Andishe Attarbaschi, Edita Kabickova, Wolfram Klapper, Wilhelm Woessmann, Birgit Burkhardt
No abstract text is available yet for this article.
August 2, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28771658/a-clearer-light-on-the-role-of-nk-cells-in-haematological-malignancies
#19
EDITORIAL
Peter Hokland, Marianne Hokland
No abstract text is available yet for this article.
August 2, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28770576/transformed-waldenstr%C3%A3-m-macroglobulinaemia-clinical-presentation-and-outcome-a-multi-institutional-retrospective-study-of-77-cases-from-the-french-innovative-leukemia-organization-filo
#20
Eric Durot, Cécile Tomowiak, Anne-Sophie Michallet, Jehan Dupuis, Bénédicte Hivert, Stéphane Leprêtre, Elise Toussaint, Sophie Godet, Fatiha Merabet, Eric Van Den Neste, Sarah Ivanoff, Xavier Roussel, Jean-Marc Zini, Caroline Regny, Richard Lemal, Laurent Sutton, Aurore Perrot, Katell Le Dû, Lukshe Kanagaratnam, Pierre Morel, Véronique Leblond, Alain Delmer
Histological transformation (HT) to diffuse large B-cell lymphoma (DLBCL) is a rare and poorly reported complication of Waldenström macroglobulinaemia (WM). We performed a retrospective study of 77 WM patients with biopsy-proven transformation to DLBCL. The median time from WM diagnosis to HT was 4·6 years and 16 patients (21%) had never been treated for WM. At HT, extranodal sites were observed in 91% of patients with a rather high incidence of central nervous system, cutaneous or testicular involvement...
August 2, 2017: British Journal of Haematology
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