journal
MENU ▼
Read by QxMD icon Read
search

British Journal of Haematology

journal
https://www.readbyqxmd.com/read/27905102/elevated-fetal-haemoglobin-is-a-predictor-of-better-outcome-in%C3%A2-mds-aml-patients-receiving-5-aza-2-deoxycytidine-decitabine
#1
Michael Lübbert, Gabriele Ihorst, Philipp N Sander, Ljudmila Bogatyreva, Heiko Becker, Pierre W Wijermans, Stefan Suciu, Emmanuel Bissé, Rainer Claus
Although azanucleoside DNA-hypomethylating agents (HMAs) are routinely used for the treatment of myelodysplastic syndrome/acute myeloid leukaemia (MDS/AML), very few outcome predictors have been established. Expression of the β-like globin gene locus is tightly regulated by DNA methylation, is HMA-sensitive in vitro, and fetal haemoglobin (HbF) expression is under study as a potential biomarker for response of MDS patients to azacitidine. We determined HbF expression in 16 MDS and 36 AML patients receiving decitabine (DAC)...
December 1, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27905100/the-severity-of-anaemia-depletes-cerebrovascular-dilatory-reserve-in-children-with-sickle-cell-disease-a-quantitative-magnetic-resonance-imaging-study
#2
Przemyslaw D Kosinski, Paula L Croal, Jackie Leung, Suzan Williams, Isaac Odame, Gregory M T Hare, Manohar Shroff, Andrea Kassner
Overt ischaemic stroke is one of the most devastating complications in children with sickle cell disease (SCD). The compensatory response to anaemia in SCD includes an increase in cerebral blood flow (CBF) by accessing cerebrovascular dilatory reserve. Exhaustion of dilatory reserve secondary to anaemic stress may lead to cerebral ischaemia. The purpose of this study was to investigate CBF and cerebrovascular reactivity (CVR) using magnetic resonance imaging (MRI) in children with SCD and to correlate these with haematological markers of anaemia...
December 1, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27897332/recent-advances-in-t-cell-immunotherapy-for-haematological-malignancies
#3
REVIEW
Rayne H Rouce, Sandhya Sharma, Mai Huynh, Helen E Heslop
In vitro discoveries have paved the way for bench-to-bedside translation in adoptive T cell immunotherapy, resulting in remarkable clinical responses in a variety of haematological malignancies. Adoptively transferred T cells genetically modified to express CD19 CARs have shown great promise, although many unanswered questions regarding how to optimize T-cell therapies for both safety and efficacy remain. Similarly, T cells that recognize viral or tumour antigens though their native receptors have produced encouraging clinical responses...
November 29, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27897314/comment-on-addendum-to-the-british-committee-for-standards-in-haematology-bcsh-guidelines-for-the-use-of-fresh-frozen-plasma-cryoprecipitate-and-cryosupernatant-2004-br-j-haematol-2004-126-11-28
#4
LETTER
https://www.readbyqxmd.com/read/27897311/the-evolutionary-and-clinical-implications-of-the-uneven-distribution-of-the-frequency-of-the-inherited-haemoglobin-variants-over-short-geographical-distances
#5
Anuja Premawardhena, Angela Allen, Fred Piel, Chris Fisher, Laxman Perera, Rexan Rodrigo, Gayan Goonathilaka, Lebbe Ramees, Tim Peto, Nancy Olivieri, David Weatherall
Studies of the frequency of heterozygous carriers for common inherited diseases of haemoglobin in over 7500 adolescent children in 25 districts in Sri Lanka have disclosed a highly significant variation over very short geographical distances. A further analysis of these findings, including their relationship to the past frequency and distribution of malaria, climatic variation, altitude, ethnic origin and consanguinity rates, have provided evidence regarding the evolutionary basis for the variable distribution of these conditions over short distances...
November 29, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27897310/c-reactive-protein-prior-to-myeloablative-allogeneic-haematopoietic-cell-transplantation-identifies-patients-at-risk-of-early-and-long-term-mortality
#6
LETTER
Amit Patel, Richard M Szydlo, Holger W Auner, Edward J Kanfer, Donald H MacDonald, Dragana Milojkovic, Syed Altaf, Andrew Innes, Ian Gabriel, Amin Rahemtulla, Aristeidis Chaidos, Anastasios Karadimitris, Eduardo Olavarria, Jane F Apperley, Jiří Pavlů
No abstract text is available yet for this article.
November 29, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27891588/whole-body-mri-reveals-high-incidence-of-osteonecrosis-in-children-treated-for-hodgkin-lymphoma
#7
Annemieke S Littooij, Thomas C Kwee, Goya Enríquez, Jonathan I M L Verbeke, Claudio Granata, Auke Beishuizen, Charlotte de Lange, Floriana Zennaro, Marrie C A Bruin, Rutger A J Nievelstein
Osteonecrosis is a well-recognized complication in patients treated with corticosteroids. The incidence of osteonecrosis in children treated for Hodgkin lymphoma is unknown because prospective whole-body magnetic resonance imaging (MRI) studies are lacking in this patient population. Paediatric patients with newly diagnosed Hodgkin lymphoma who were treated according to a uniform paediatric Hodgkin protocol were eligible for inclusion in this prospective study. Whole-body MRI was performed in all 24 included patients (mean age 15·1 years, 12 girls) both before treatment and after 2 cycles of chemotherapy, and in 16 patients after completion of chemotherapy...
November 28, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27891583/the-use-of-anthracyclines-in-the-treatment-of-endemic-burkitt-lymphoma
#8
Elizabeth Molyneux, Ed Schwalbe, George Chagaluka, Kondwani Banda, Trijn Israels, Sarita Depani, Kirstin Mittermayer-Vassallo, Kevin Windebank, Jessie Mvula, Jenala Njiram'madzi, Stephen O'Brien, Peter Carey, Simon Bailey
Burkitt lymphoma is the most common malignancy in children in Malawi, the world's poorest country, where there is a long history of treating this disease using a 28-day cyclophosphamide-based protocol. Stage III/IV disease has had poor outcomes. In an attempt to improve the outcome for higher stage disease, anthracyclines were added to the existing protocol. The disease-free (DFS) and overall survival (OS) of 58 children with cytologically confirmed Burkitt lymphoma admitted during 2012-2014 and treated using this protocol were calculated...
November 28, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27891581/antigen-specificity-determines-anti-red-blood-cell-igg-fc-alloantibody-glycosylation-and-thereby-severity-of-haemolytic-disease-of-the-fetus-and-newborn
#9
Myrthe E Sonneveld, Joke Koelewijn, Masja de Haas, Jon Admiraal, Rosina Plomp, Carolien A M Koeleman, Agnes L Hipgrave Ederveen, Peter Ligthart, Manfred Wuhrer, C Ellen van der Schoot, Gestur Vidarsson
Haemolytic disease of the fetus and newborn (HDFN) is a severe disease in which fetal red blood cells (RBC) are destroyed by maternal anti-RBC IgG alloantibodies. HDFN is most often caused by anti-D but may also occur due to anti-K, -c- or -E. We recently found N-linked glycosylation of anti-D to be skewed towards low fucosylation, thereby increasing the affinity to IgG-Fc receptor IIIa and IIIb, which correlated with HDFN disease severity. Here, we analysed 230 pregnant women with anti-c, -E or -K alloantibodies from a prospective screening cohort and investigated the type of Fc-tail glycosylation of these antibodies in relation to the trigger of immunisation and pregnancy outcome...
November 28, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27879999/addendum-to-the-british-committee-for-standards-in-haematology-bcsh-guidelines-for-the-use-of-fresh-frozen-plasma-cryoprecipitate-and-cryosupernatant-2004-br-j-haematol-2004-126-11-28-response-to-neisser-svae-and%C3%A2-heger
#10
LETTER
Laura Green, Rebecca Cardigan, Craig Beattie, Paula Bolton-Maggs, Simon J Stanworth, Jecko Thachil, Yiannis Kallis, Sharon Zahra
No abstract text is available yet for this article.
November 23, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27879997/a-united-kingdom-immune-thrombocytopenia-itp-forum-review-of-practice-thrombopoietin-receptor-agonists
#11
LETTER
Jecko Thachil, Catherine Bagot, Charlotte Bradbury, Nichola Cooper, Will Lester, John D Grainger, Gillian Lowe, Gillian Evans, Kate Talks, Keith Sibson, Mamta Garg, Michael F Murphy, Henry G Watson, Paula H B Bolton-Maggs, Shirley Watson, Marie Scully, Drew Provan, Adrian Newland, Quentin A Hill
No abstract text is available yet for this article.
November 23, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27879994/a-new-mutation-of-ano6-in-two-familial-cases-of-scott-syndrome
#12
LETTER
Pierre Boisseau, Marie C Bene, Thomas Besnard, Sinthuja Pachchek, Mathilde Giraud, Patricia Talarmain, Nelly Robillard, Marie A Gourlaouen, Stéphane Bezieau, Marc Fouassier
No abstract text is available yet for this article.
November 23, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27879992/spleen-hypofunction-in-eosinophilic-gastrointestinal-disease
#13
Antonio Di Sabatino, Alessandro Vanoli, Rosangela Invernizzi, Gino R Corazza
No abstract text is available yet for this article.
November 23, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27879990/sequential-chemotherapy-followed-by-reduced-intensity-conditioning-and-allogeneic-haematopoietic-stem-cell-transplantation-in-adult-patients-with-relapse-or-refractory-acute-myeloid-leukaemia-a-survey-from-the-acute-leukaemia-working-party-of-ebmt
#14
Olle Ringdén, Myriam Labopin, Christoph Schmid, Behnam Sadeghi, Emmanuelle Polge, Johanna Tischer, Arnold Ganser, Mauricette Michallet, Lothar Kanz, Rainer Schwerdtfeger, Arnon Nagler, Mohamad Mohty
This study analysed the outcome of 267 patients with relapse/refractory acute myeloid leukaemia (AML) who received sequential chemotherapy including fludarabine, cytarabine and amsacrine followed by reduced-intensity conditioning (RIC) and allogeneic haematopoietic stem cell transplantation (HSCT). The transplants in 77 patients were from matched sibling donors (MSDs) and those in 190 patients were from matched unrelated donors. Most patients (94·3%) were given anti-T-cell antibodies. The incidence of acute graft-versus-host disease (GVHD) of grades II-IV was 32·1% and that of chronic GVHD was 30·2%...
November 23, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27879989/cd274-pd-l1-pdcd1-pd-1-expression-in-de-novo-and-transformed-diffuse-large-b-cell-lymphoma
#15
LETTER
Anna Kwiecinska, Nikolaos Tsesmetzis, Mehran Ghaderi, Lorand Kis, Leonie Saft, George Z Rassidakis
No abstract text is available yet for this article.
November 23, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27879988/immune-thrombocytopenia-a-need-for-assisted-suicide
#16
EDITORIAL
James B Bussel, Nichola Cooper
No abstract text is available yet for this article.
November 23, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27879987/ocular-extramedullary-myeloid-leukaemia
#17
LETTER
Maro Ohanian, Naveen Pemmaraju, Uri Rozovski, Mona L Alattar, Zeev Estrov, Vikas Kundra, Cynthia Tung, Farhad Ravandi, John Manning, Lynne V Abruzzo
No abstract text is available yet for this article.
November 23, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27859002/statistical-reporting-in-the-bjh-some-dos-and-don-ts
#18
REVIEW
Robert K Hills
Statistics provides an important tool to enable large amounts of data from an experiment to be summarised and conclusions drawn. To be informative statistics need to serve the experimenter appropriately and give clear and understandable answers. It is important that the reader can clearly understand the methodology used, and that that methodology is appropriate to the situation. We present here some issues to be considered when writing for publication in the British Journal of Haematology (BJH).
November 18, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27859001/a-phase-iib-trial-of-vorinostat-in-combination-with-lenalidomide-and-dexamethasone-in-patients-with-multiple-myeloma-refractory-to-previous-lenalidomide-containing-regimens
#19
Larysa Sanchez, David H Vesole, Joshua R Richter, Noa Biran, Elizabeth Bilotti, Laura McBride, Palka Anand, Kristin Ivanovski, David S Siegel
Clinical trials of vorinostat, a Class I/II histone deacetylase inhibitor, in combination with proteasome inhibitors and immunomodulatory agents have shown activity in relapsed/refractory multiple myeloma. This phase IIb, open-label, single-institution study evaluated the efficacy of vorinostat in combination with lenalidomide and dexamethasone in lenalidomide-refractory patients. Patients were considered lenalidomide-refractory if they had no clinical response (<minimal response) on a previous lenalidomide-containing regimen (lenalidomide non-responsive) or if they had progressive disease on or within 60 days of discontinuing a previous lenalidomide-containing regimen (lenalidomide relapsed/refractory)...
November 18, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27858994/guidelines-on-red-cell-transfusion-in-sickle-cell-disease-part-ii-indications-for-transfusion
#20
LETTER
Bernard A Davis, Shubha Allard, Amrana Qureshi, John B Porter, Shivan Pancham, Nay Win, Gavin Cho, Kate Ryan
No abstract text is available yet for this article.
November 18, 2016: British Journal of Haematology
journal
journal
20057
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"