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British Journal of Haematology

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https://www.readbyqxmd.com/read/30637732/mesenchymal-stromal-cells-for-acute-graft-versus-host-disease-response-at-1-week-predicts-probability-of-survival
#1
Antonio Galleu, Dragana Milojkovic, Simona Deplano, Richard Szydlo, Sandra Loaiza, Robert Wynn, David I Marks, Deborah Richardson, Kim Orchard, Edward Kanfer, Eleni Tholouli, Muhammad Saif, Ponni Sivaprakasam, Sarah Lawson, Adrian Bloor, Antonio Pagliuca, Victoria Potter, Varun Mehra, John A Snowden, Ajay Vora, Bhuvan Kishore, Hannah Hunter, Jane F Apperley, Francesco Dazzi
Mesenchymal stromal cells (MSCs) have been successfully used for the treatment of steroid-resistant graft-versus-host-disease (GvHD). However, the lack of early predictors of clinical responses impacts on the time at which to add further treatment and consequently the design of informative clinical trials. Here, we present the UK experience of one of the largest cohorts of GvHD patients undergoing MSC infusions so far reported. We show that clinical responses assessed as early as 1 week after MSC infusion predict patients' overall survival...
January 13, 2019: British Journal of Haematology
https://www.readbyqxmd.com/read/30637714/radiation-exposure-and-longitudinal-changes-in-peripheral-monocytes-over-50-years-the-adult-health-study-of-atomic-bomb-survivors
#2
Kengo Yoshida, Benjamin French, Noriaki Yoshida, Ayumi Hida, Waka Ohishi, Yoichiro Kusunoki
Enhanced inflammatory responses have been suggested decades after radiation exposure in atomic-bomb survivors, but cellular and molecular alterations related to prolonged inflammation remain unclear. This study, utilizing longitudinal haematological data over 50 years for 14 000 persons, investigated whether radiation exposure promoted the relative increase in peripheral myeloid cells, known as an aging-associated indicator of low-grade inflammation. Statistical modelling was performed with a linear mixed-effects model for leucocyte subsets, together with a proportional hazards regression model for all-cause mortality...
January 13, 2019: British Journal of Haematology
https://www.readbyqxmd.com/read/30632137/thrombophilia-screening-and-thromboprophylaxis-may-benefit-specific-ethnic-subgroups-with-paediatric-acute-lymphoblastic-leukaemia
#3
Shlomit Barzilai-Birenboim, Nira Arad-Cohen, Ronit Nirel, Galia Avrahami, Dan Harlev, Gil Gilad, Ronit Elhasid, Shai Izraeli, Naomi Litichever, Sarah Elitzur
This study investigated the prevalence of inherited thrombophilia, risk of venous thromboembolism (VTE) and benefit of low molecular weight heparin prophylaxis in 476 Israeli children with acute lymphoblastic leukaemia (ALL) treated between 2004 and 2016. Thrombophilia was found in 15·5%. Arab children had a higher prevalence of F5 R506Q (factor V Leiden) than Jewish children (19·4% vs. 2·9%, P < 0·01). Patients with thrombophilia had higher VTE rates VTE (26·5% vs. 5·6%, P < 0·001). None of the thrombophilic children given prophylaxis had severe VTE...
January 10, 2019: British Journal of Haematology
https://www.readbyqxmd.com/read/30613948/mature-b-nhl-in-children-adolescents-and-young-adults-current-therapeutic-approach-and-emerging-treatment-strategies
#4
REVIEW
Grace Egan, Stan Goldman, Sarah Alexander
Mature B cell lymphomas account for approximately 60% of all cases of non-Hodgkin lymphoma (NHL) in children and adolescents and includes Burkitt lymphoma (BL), diffuse large B cell lymphoma (DLBCL) and other less common histologies. The outcome for patients treated with modern regimens in resource-intensive settings is excellent. Improvements in care have been accomplished through enhanced supportive therapy, including tumour lysis management and incremental refinement of chemotherapy backbones via cooperative group clinical trials in which patients receive risk group-specific intensive chemotherapy...
January 6, 2019: British Journal of Haematology
https://www.readbyqxmd.com/read/30613940/isolated-cutaneous-lymphomatous-form-of-adult-t-cell-leukaemia-lymphoma
#5
Alex Bataller, Andrea Combalia, Adriana Garcia-Herrera, Teresa Estrach, Estella Matutes
No abstract text is available yet for this article.
January 6, 2019: British Journal of Haematology
https://www.readbyqxmd.com/read/30613939/advances-in-cellular-and-humoral-immunotherapy-implications-for-the-treatment-of-poor-risk-childhood-adolescent-and-young-adult-b-cell-non-hodgkin-lymphoma
#6
REVIEW
Yaya Chu, Aliza Gardenswartz, Amanda M Termuhlen, Mitchell S Cairo
Patients with relapsed, refractory or advanced stage B non-Hodgkin lymphoma (NHL) continue to have a dismal prognosis. This review summarises current and novel cellular and immunotherapy for these high-risk populations, including haematopoietic stem cell transplant, bispecific antibodies, viral-derived cytotoxic T cells, chimeric antigen receptor (CAR) T cells, and natural killer (NK) cell therapy, as discussed at the 6th International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma on September 26th-29th 2018 in Rotterdam, the Netherlands, and explores the future of NK/CAR NK therapies...
January 6, 2019: British Journal of Haematology
https://www.readbyqxmd.com/read/30609018/the-prevention-of-glucocorticoid-induced-osteoporosis-in-patients-with-immune-thrombocytopenia-receiving-steroids-a-british-society-for-haematology-good-practice-paper
#7
LETTER
Quentin A Hill, John D Grainger, Jecko Thachil, Drew Provan, Gillian Evans, Mamta Garg, Charlotte Bradbury, Catherine Bagot, John A Kanis, Juliet E Compston
No abstract text is available yet for this article.
January 4, 2019: British Journal of Haematology
https://www.readbyqxmd.com/read/30609016/the-management-of-primary-mediastinal-b-cell-lymphoma-a-british-society-for-haematology-good-practice-paper
#8
LETTER
Kate Cwynarski, Maria A V Marzolini, Sally F Barrington, George Follows, Timothy Illidge, Simon Stern, Andrew Davies
No abstract text is available yet for this article.
January 4, 2019: British Journal of Haematology
https://www.readbyqxmd.com/read/30609015/a-new-case-of-heterozygous-variant-of-the-gp1bb-gene-responsible-for-macrothrombocytopenia
#9
LETTER
Antoine Babuty, Pierre Boisseau, Marion Eveillard, Catherine Ternisien, Camille Debord, Marianne Sigaud, Mathilde Giraud, Benjamin Gillet, Marc Trossaert, Marie-Christine Béné, Marc Fouassier
No abstract text is available yet for this article.
January 4, 2019: British Journal of Haematology
https://www.readbyqxmd.com/read/30592297/interleukin-17-producing-angioimmunoblastic-t-cell-lymphoma-with-evans-syndrome
#10
Shoko Nakayama, Takahide Taniguchi, Hirokazu Tanaka, Jorge L Espinoza, Shinya Rai, Itaru Matsumura
No abstract text is available yet for this article.
December 28, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30592296/cbfa2t3-glis2-positive-acute-myeloid-leukaemia-a-peculiar-paediatric-entity
#11
REVIEW
Riccardo Masetti, Salvatore N Bertuccio, Andrea Pession, Franco Locatelli
The scenario of paediatric acute myeloid leukaemia (AML), particularly non-Down syndrome acute megakaryoblastic leukaemia (non-DS-AMKL), has been recently revolutionized by the advent of large-scale, genomic sequencing technologies. In this changing landscape, a significantly relevant discovery has been represented by the identification of the CBFA2T3-GLIS2 fusion gene, which is the result of a cryptic inversion of chromosome 16. It is the most frequent chimeric oncogene identified to date in non-DS-AMKL, although it seems not to be exclusively restricted to the French-American-British M7 subgroup...
December 28, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30592294/acquired-elliptocytosis-in-a-patient-with-a-myelodysplastic-syndrome-associated-with-20q-deletion
#12
Keina S Quiroz-Cervantes, Luis Miguel Juárez-Salcedo, Irene Nuevo, Helga Guillén, Jaime Arbeteta, Nuria Golbano
No abstract text is available yet for this article.
December 28, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30592034/haemophilia-and-ageing
#13
REVIEW
Susan Shapiro, Mike Makris
Advances in the development of effective and safe treatments for haemophilia over the last 50 years have resulted in a significant increase in the life expectancy of persons with haemophilia (PWH). The management of this new cohort of middle-aged and elderly PWH is challenging because of the opposing risks of haemophilia and age-related cardiovascular disease and malignancy. Furthermore, this cohort of ageing PWH has the additional comorbidities of human immunodeficiency virus/hepatitis C and chronic haemophilic arthropathy...
December 28, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30592029/ten-year-single-centre-experience-in-fertility-preservation-of-459-patients-suffering-from-acute-leukaemia
#14
Jasmine Noetzli, Sophie Voruz, Dorothea Wunder, Marie-Pierre Primi, Olivier Spertini, Sabine Blum
Acute leukaemia is a life-threatening disease that needs treatment without delay. Fertility preservation is recommended, but often not possible because of the necessity to start treatment as soon as possible. The present study is a retrospective single-centre analysis of 459 patients diagnosed with acute leukaemia between 2002 and 2012. Sperm or oocyte preservation was successfully performed in only 29 (6%) patients. Of the 150 children, no paediatric patient sample was taken. The collected samples enabled the conception of 2 children by in vitro fertilisation; in addition, 3 spontaneous, non-assisted births in partners of male patients were observed...
December 28, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30592027/doxorubicin-vinblastine-dacarbazine-and-lenalidomide-for-older-hodgkin-lymphoma-patients-final-results-of-a-german-hodgkin-study-group-ghsg-phase-i-trial
#15
Boris Böll, Annette Plütschow, Carolin Bürkle, Johannes Atta, Michael Pfreundschuh, Michaela Feuring-Buske, Martin Vogelhuber, Martin Sökler, Dennis A Eichenauer, Indra Thielen, Bastian von Tresckow, Michael Fuchs, Andreas Engert, Peter Borchmann
About 30% of all Hodgkin lymphoma (HL) patients are ≥60 years old. As lenalidomide has promising single agent activity in multiple relapsed HL, we replaced bleomycin in ABVD with lenalidomide in this phase-I trial. Patients aged ≥60 years with early-unfavourable- or advanced-stage HL (Eastern Cooperative Oncology Group performance status ≤2, Cumulative Illness Rating Scale for Geriatrics score 0-7) received 4-8 cycles of AVD (doxorubicin, vinblastine, dacarbazine) and lenalidomide in escalation with overdose control...
December 28, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30592026/a-pilot-study-of-weekly-brentuximab-vedotin-in-patients-with-cd30-malignancies-resistant-to-brentuximab-vedotin-every-3-weeks
#16
LETTER
Jacqueline N Poston, Jonathan R Fromm, Heather A Rasmussen, Andrei R Shustov, Edward N Libby, Stephen D Smith, Ted Gooley, Ajay K Gopal
No abstract text is available yet for this article.
December 28, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30592025/clinical-benefit-of-depth-of-response-for-relapsed-refractory-multiple-myeloma-patients-treated-on-clinical-trials-retrospective-analysis-from-two-tertiary-centres
#17
LETTER
Esther H L Chan, Dunnya De-Silva, Adeline H F Lin, Neil Rabin, Ashutosh Wechalekar, Rakesh Popat, Wee Joo Chng, Kwee L Yong
No abstract text is available yet for this article.
December 28, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30592036/transfusion-strategies-for-major-haemorrhage-in-trauma
#18
REVIEW
Nicola S Curry, Ross Davenport
Trauma is a leading cause of death worldwide in persons under 44 years of age, and uncontrolled haemorrhage is the most common preventable cause of death in this patient group. The transfusion management of trauma haemorrhage is unrecognisable from 20 years ago. Changes in clinical practice have been driven primarily by an increased understanding of the pathophysiology of trauma-induced coagulopathy (TIC), which is associated with poor clinical outcomes, including a 3- to 4-fold increased risk of death. Targeting this coagulopathy alongside changes to surgical and anaesthetic practices (an overarching strategy known as damage control surgery/damage control resuscitation) has led to a significant reduction in mortality rates over the last two decades...
December 27, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30592028/real-world-data-and-the-art-of-maintenance-therapy
#19
EDITORIAL
Robert K Hills
No abstract text is available yet for this article.
December 27, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30592023/the-duffy-antigen-receptor-for-chemokines-ackr1-jeanne-darc-of-benign-neutropenia
#20
REVIEW
Naama Rappoport, Amos J Simon, Ninette Amariglio, Gideon Rechavi
Benign neutropenia, observed in different ethnic groups, is the most common form of neutropenia worldwide. A specific single nucleotide polymorphism, rs2814778, located at the promoter of the ACKR1 (previously termed DARC) gene, which disrupts a binding site for the GATA1 erythroid transcription factor, resulting in a ACKR1-null phenotype, was found to serve as a predictor of low white blood cell and neutrophil counts in African-Americans and Yemenite Jews. Individuals with benign neutropenia due to the ACKR1-null allele have been found to have an increased susceptibility to human immunodeficiency virus infection and, on the other hand, a protective effect against malaria...
December 27, 2018: British Journal of Haematology
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