We have located links that may give you full text access.
Comparative Study
Journal Article
Comparative analysis of the neurula transcriptomes of two species of flatfishes: Platichthys stellatus and Paralichthys olivaceus.
Gene 2017 January 6
Flatfish with left-right eye asymmetry are the most significant among vertebrates. However, the genetic basis for the control of this characteristic is still unclear. We propose that the gene(s) for eye asymmetry initially control minor differences in cell number in the tissues around the eyes during eye development. This minor difference is then amplified, causing eye migration during metamorphosis. Therefore, comparing the neurula transcriptomes between flatfish species with different eye-reversal mutants may provide very useful information to screen for genes involved in eye asymmetry. In this study, two cDNA libraries constructed from neurulas of P. stellatus (high ratio of eye reversal) and P. olivaceus (very low ratio of eye reversal) were sequenced and compared. There were 8121 and 8108 unigenes annotated to 32 categories in P. stellatus and P. olivaceus, respectively, and the highest KEGG pathways in both species were 'signal transduction', 'immune system', and 'endocrine system'. In total, 62,692 and 18,938 putative single nucleotide polymorphisms (SNPs) were predicted in the P. stellatus and P. olivaceus transcriptomes, respectively. Furthermore, 8026 SNPs found in P. stellatus did not exist in P. olivaceus. Fifty-one SNPs were identified in nine genes (Fgf7, Wnt9, Sfrp2, Bmpr1B, Bmpr2, Pax3, Pax6, Six1 and Tgfβr2) related to eye development. In particular, Tgfβr2 with Asp77Glu found in P. stellatus but not in P. olivaceus will provide important information for screening genes associated with eye asymmetry.
Full text links
Related Resources
Trending Papers
Consensus Statement on Vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows.Endocrine Reviews 2024 April 28
The Tricuspid Valve: A Review of Pathology, Imaging, and Current Treatment Options: A Scientific Statement From the American Heart Association.Circulation 2024 April 26
Intravenous infusion of dexmedetomidine during the surgery to prevent postoperative delirium and postoperative cognitive dysfunction undergoing non-cardiac surgery: a meta-analysis of randomized controlled trials.European Journal of Medical Research 2024 April 19
Interstitial Lung Disease: A Review.JAMA 2024 April 23
Ventilator Waveforms May Give Clues to Expiratory Muscle Activity.American Journal of Respiratory and Critical Care Medicine 2024 April 25
Acute Kidney Injury and Electrolyte Imbalances Caused by Dapagliflozin Short-Term Use.Pharmaceuticals 2024 March 27
Systemic lupus erythematosus.Lancet 2024 April 18
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app