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https://www.readbyqxmd.com/read/30419251/the-role-of-egfr-overexpression-on-the-recurrence-of-basal-cell-carcinomas-with-positive-surgical-margins
#1
Cigir Biray Avci, Isa Kaya, Arin Ozturk, Neslihan Pinar Ozates Ay, Baha Sezgin, Cansu Caliskan Kurt, Nurullah Serdar Akyildiz, Aykut Bozan, Banu Yaman, Taner Akalin, Fazil Apaydin
BACKGROUND: Epidermal growth factor receptor (EGFR) expression may have role on recurrence of basal cell carcinoma (BCC) with positive surgical margin(s). OBJECTIVE: The aim was to investigate the role of genetic expression changes of EGFR on recurrence rates in patients in follow up with surgically excised BCC with positive surgical margin(s). METHODS: Thirty-four surgical margin-positive BCC lesions that were closely followed up without an immediate reoperation were included in this study...
November 9, 2018: Gene
https://www.readbyqxmd.com/read/30419250/revisiting-the-association-of-hla-alleles-and-haplotypes-with-cyp21a2-mutations-in-a-large-cohort-of-patients-with-congenital-adrenal-hyperplasia
#2
Rahul Jayakrishnan, Qizong Lao, Sharon D Adams, William W Ward, Deborah P Merke
The CYP21A2 gene encoding 21‑hydroxylase is on chromosome 6p21.3 within the human leukocyte antigen (HLA) class III major histocompatibility complex and an association between congenital adrenal hyperplasia (CAH) due to 21‑hydroxylase deficiency and HLA class I and II alleles has been shown in genetically isolated populations. One-third of CAH causing alleles are 30-kb deletions due to homologous recombination events between active and pseudogenes resulting in chimeric genes. The aim of this study was to re-visit the association between the CYP21A2 variants and HLA polymorphisms in a large ethnically diverse cohort of patients with CAH who underwent comprehensive CYP21A2 genotyping, including specification of chimeric gene subtypes (CAH CH-1 through CH-9 of CYP21A1P/CYP21A2 chimeras; CAH-X CH-1 through CH-3 of TNXA/TNXB chimeras) in alleles with 30-kb deletions...
November 9, 2018: Gene
https://www.readbyqxmd.com/read/30415011/dmrt1-directly-regulates-the-transcription-of-the-testis-biased-sox9b-gene-in-nile-tilapia-oreochromis-niloticus
#3
Ling Wei, Xiaoyan Li, Minghui Li, Yaohao Tang, Jing Wei, Deshou Wang
The Nile tilapia Sox9b gene is characterized as a homolog of the mammalian Sox9 gene, which exhibits testis-biased expression and is involved in testis development. However, the transcriptional regulation of the Sox9b gene is poorly understood. In this study, we demonstrated that the male sex differentiation gene doublesex and mab-3 related transcription factor 1 (Dmrt1) was predominantly expressed in the Nile tilapia testis and that Dmrt1 knockdown in the Nile tilapia decreased the expression of the Sox9b gene in the testis...
November 8, 2018: Gene
https://www.readbyqxmd.com/read/30415010/in-depth-study-of-lin-28-suggests-selectively-conserved-let-7-independent-mechanism-in-drosophila
#4
Mihye Lee, Thanh My Thi Nguyen, Kiyoung Kim
Lin-28 is a conserved RNA-binding protein that is involved in a wide range of developmental processes and pathogenesis. At the molecular level, Lin-28 blocks the maturation of let-7 and regulates translation of certain mRNA targets. In Drosophila, Lin-28 is reported to play a role in oogenesis, muscle formation, and the symmetric division of adult intestinal stem cells. In this study, we characterized Drosophila Lin-28 through a detailed examination of its temporal and spatial expression. Lin-28 is specifically expressed in embryonic nervous and cardiac systems...
November 8, 2018: Gene
https://www.readbyqxmd.com/read/30415009/expression-and-prognosis-analyses-of-forkhead-box-a-foxa-family-in-human-lung-cancer
#5
Chaoqun Huang, Jiuyang Liu, Bin Xiong, Yutaka Yonemura, Xiaojun Yang
Despite advances in early diagnosis and treatment, cancer still remains the major reason of mortality worldwide. The forkhead box A (FOXA) family is reported to participate in diverse human diseases. However, little is known about their expression and prognostic values in human lung cancer. Herein, we conducted a detailed cancer vs. normal analysis. The mRNA expression levels of FOXA family in numerous kind of cancers, including lung cancer, were analyzed using the Oncomine and GEPIA database. We observed that the mRNA expression levels of FOXA1, and FOXA3 were all increased while FOXA2 were decreased in most cancers compared with normal tissues, especially in lung cancer...
November 8, 2018: Gene
https://www.readbyqxmd.com/read/30415008/expression-profile-analysis-identifies-the-long-non-coding-rna-landscape-and-the-potential-carcinogenic-functions-of-linc00668-in-laryngeal-squamous-cell-carcinoma
#6
Lei Zhao, Huan Cao, Weiwei Chi, Wenxia Meng, Weina Cui, Wei Guo, Baoshan Wang
In order to explore the differentially expressed long non-coding RNAs (lncRNAs) in laryngeal squamous cell carcinoma (LSCC), the GSE84957 lncRNA expression profile was included in the present study through data mining in the National Center for Biotechnology Information/Gene Expression Omnibus (NCBI/GEO). Then, the differentially expressed genes (DEGs) of LSCC (1646 lncRNAs and 2713 mRNAs, fold change ≥ 2, P ≤ 0.05) were identified from the GSE84957 dataset using bioinformatics analysis. Of the 10 selected differentially expressed lncRNAs, the expression of 7 lncRNAs were verified by qRT-PCR method...
November 8, 2018: Gene
https://www.readbyqxmd.com/read/30415007/combined-treatment-of-abt199-and-irinotecan-suppresses-kras-mutant-lung-cancer-cells
#7
Yinhai Xu, Shuai Zong, Xin Gao, Haoliang Zhang, Bin Wang, Pengpeng Li, Tielong Liu, Shibao Li
Lung cancer has become the most prevalent neoplasm throughout the world with 1,2 million deaths per year. Molecular genetic analyses have suggested that KRAS mutation is much more frequency in NSCLC. Significant challenges are to develop selective pharmacological inhibitors for RAS mutation to treat cancers driven. In our study, we used the combinatorial strategy to target oncogene addiction for RAS-mutant cells and the data showed that ABT199 and irinotecan leads to RAS-mutant lung cancer cell growth inhibition and enhanced apoptosis in vitro and in vivo...
November 8, 2018: Gene
https://www.readbyqxmd.com/read/30415006/overexpression-of-long-non-coding-rna-ca3-as1-suppresses-proliferation-invasion-and-promotes-apoptosis-via-mirna-93-pten-axis-in-colorectal-cancer
#8
Hua Wei, Zhichao Yang, Bo Lin
AIMS: In previous studies, dysregulated lncRNAs in colorectal cancer were screened using RNA-sequencing by Atsushi Yamada. In these dysregulated lncRNAs, a long non coding RNA named CA3-AS1 attracted our attention due to its high conservation and fold change, which was downregulated in colorectal cancer. In this study, we aimed to investigate the function and mechanism of lncRNA CA3-AS1 in colorectal cancer. METHODS: RT-PCR was used to detect CA3-AS1, miR-93, PTEN mRNA expression...
November 8, 2018: Gene
https://www.readbyqxmd.com/read/30415005/inhibition-of-mir-423-5p-suppressed-prostate-cancer-through-targeting-grim-19
#9
Haili Lin, Tianqi Lin, Jiangui Lin, Minggen Yang, Zaixiong Shen, Hongjie Liu, Zongkai Zou, Zhouda Zheng
OBJECTIVE: To determine the effect of miR-423-5p on the progression of prostate cancer (PC). METHODS: miR-423-5p and GRIM-19 expressions were detected by qRT-PCR and western blot. PC cell proliferation was measured by MTT assay. PC cell apoptosis was detected by flow cytometry. Dual luciferase reporter assay was used to confirm the interaction between miR-423-5p and GRIM-19. RESULTS: Compared with normal prostate tissues and prostate epithelial cell HPrEC, miR-423-5p was up-regulated in human PC tissues and PC3 cells, whereas GRIM-19 expression was decreased...
November 8, 2018: Gene
https://www.readbyqxmd.com/read/30412747/analysis-of-ub-and-l40-related-to-deltamethrin-stress-in-the-diamondback-moth-plutella-xylostella-l
#10
Xiaoli Ying, Qingping Chi, Mengying Ge, Yahui Liu, Lu Chen, Fengliang Li, Luogen Cheng
Pests have been subjected to heavy selection by insecticide pressure, producing greater and more serious resistance. It is extremely valuable to identify the resistance genes that are relevant for pest control. In our previous studies, we reported that UBL40 is the deltamethrin resistance-associated gene. UBL40 is cleaved by specific endopeptidases to release UB and L40. Therefore, further we compared the expression of UB and L40 in different tissues from larvae of the diamondback moth using a deltamethrin-resistant (DR) strain and a deltamethrin-sensitive (DS) strain...
November 6, 2018: Gene
https://www.readbyqxmd.com/read/30412746/mir-3926-inhibits-synovial-fibroblasts-proliferation-and-inflammatory-cytokines-secretion-through-targeting-toll-like-receptor-5
#11
Di Fu, Chuyin Xiao, Yingying Xie, Jianquan Gao, Shanhui Ye
Rheumatoid arthritis synovial fibroblasts (RASFs) play a key role in the pathogenesis of rheumatoid arthritis (RA). This study was aimed to investigate the effects of miR-3926 on the biological activities of RASFs. The results showed that miR-3926 was significantly down-regulated in RASFs and RA synovial tissue. Overexpression of miR-3926 significantly inhibited RASFs proliferation and decreased the secretion of inflammatory cytokines including TNF-α, IL-1β and IL-6 in RASFs. TLR5 was identified to be a direct target of miR-3926...
November 6, 2018: Gene
https://www.readbyqxmd.com/read/30412745/genetic-variations-in-inflammation-related-genes-and-their-influence-on-the-susceptibility-of-pediatric-acute-lung-injury-in-a-chinese-population
#12
Xinqian Zhao, Jing He, Guoyan Xie, Song Xu, Jun Xie, Youyuan Chen, Hui Wu
Acute lung injury (ALI) is a serious clinical syndrome that can cause respiratory failure and threaten the life of the patients. A biomarker that can predict the syndrome can contribute to a better clinical management of the patients. In adults, genetic polymorphisms in inflammatory-response genes have been shown to be a promising biomarker. However, the pathogenesis of ALI in adult is known to be different from that in children and no previous study has investigated the association between inflammatory gene polymorphisms and pediatric ALI (PALI) risk...
November 6, 2018: Gene
https://www.readbyqxmd.com/read/30408551/ezh2-mediated-epigenetic-suppression-of-ephb3-inhibits-gastric-cancer-proliferation-and-metastasis-by-affecting-e-cadherin-and-vimentin-expression
#13
Kun Zhao, Jing He, Yan-Fen Wang, Shi-Dai Jin, Yu Fan, Na Fang, Jun Qian, Tong-Peng Xu, Ren-Hua Guo
EphB3 is a member of the EPH family of receptors and has been found to play a role in the carcinogenesis of some human cancers. However, its expression and clinical significance in gastric cancer (GC) have not been well documented. In the present study, we detected the expression of EphB3 in GC and adjacent noncancerous tissues and explored its relationships with the clinicopathological features and prognosis of GC patients. It was found that EphB3 silenced GC cells epigenetically by direct transcriptional repression of GC cells via polycomb group protein EZH2 mediation...
November 5, 2018: Gene
https://www.readbyqxmd.com/read/30408550/mir-509-3p-enhances-platinum-drug-sensitivity-in-ovarian-cancer
#14
Leilei Niu, Hua Ni, Yingzi Hou, Quan Du, Hua Li
Drug-resistance of platinum remains a big challenge for effective treatment of patients with ovarian cancer. MicroRNAs (miRNAs) act as post-transcriptional regulators of gene expression and are associated with multi-drug resistance. Our study aims on identifying role of miRNAs in drug-resistance of platinum in ovarian cancer. In present study, we compared the expression profiles of miRNAs between three pairs of platinum-resistant and platinum-sensitive ovarian tissues and found that miR-509-3p was significantly down-regulated in cisplatin-resistant ovarian cancer tissues...
November 5, 2018: Gene
https://www.readbyqxmd.com/read/30408549/spleen-tyrosine-kinase-syk-protects-renal-tubular-epithelial-cell-against-hypoxia-injury-in-children-with-acute-kidney-injury
#15
Zhiyong Zhang, Ya Gao, Ximin Qiao
Spleen tyrosine kinase (SYK), which is a non-receptor protein tyrosine kinase, has been reported to be connected to the cells survival. Especially, SYK is demonstrated to have protective effect on B cells against the injury induced by the anoxia/hypoglycemia (A/H) condition. However, the role of SYK in the renal cells exposed to the A/H injury is still unclear currently. In our study, we aimed to explore the role and the molecular mechanism of SYK in renal cells with A/H injury. We found that the mRNA and protein expressions of SYK were significantly increased in the human proximal tubular epithelial cell HK-2 with the treatment of A/H injury...
November 5, 2018: Gene
https://www.readbyqxmd.com/read/30408548/mining-of-aminotransferase-gene-ota3-from-bacillus-pumilus-w3-via-genome-analysis-gene-cloning-and-expressing-for-compound-bioamination
#16
Lixin Zhai, Shaolan Yang, Yingjie Lai, Di Meng, Qiaopeng Tian, Zhengbing Guan, Yujie Cai, Xiangru Liao
Aminotransferases are widely employed as biocatalysts to produce chiral amines and biologically active pharmaceuticals via asymmetric synthesis. In this study, transaminase genes in the Bacillus pumilus W3 genome were analysed, and gene ota3 encoding a putative (R)-selective transaminase was identified. The sequence of ota3 shares highest sequence identity (24.7%) with the first (R)-selective aminotransferase from Arthrobacter sp. KNK 168. Amino acid sequence and conserved domains analyses indicated that ω-BPAT encoded by ota3 belonged to the pyridoxal 5'-phosphate-dependent class IV (PLPDE_IV) superfamily...
November 5, 2018: Gene
https://www.readbyqxmd.com/read/30408547/one-16-bp-insertion-deletion-indel-within-the-kdm6a-gene-revealing-strong-associations-with-growth-traits-in-goat
#17
Ke Wang, Yang Cui, Zhen Wang, Hailong Yan, Zhe Meng, Haijing Zhu, Lei Qu, Xianyong Lan, Chuanying Pan
Lysine demethylase 6A (KDM6A), as a candidate gene associated with skeletal dysplasia and the differentiation of osteogenesis, might affect the growth traits in animals. In the previous study (Cui et al., 2018), one 16 bp intronic insertion/deletion (NW_017189516.1: g.138, 431_138,446delAATGTATAGCTTAAAA) within the KDM6A gene significantly influenced KDM6A gene expression. The objective of this work was to investigate the association between this 16 bp indel and growth-related traits in Shaanbei White Cashmere goat (SWCG)...
November 5, 2018: Gene
https://www.readbyqxmd.com/read/30403964/association-between-rs738409-polymorphism-in-patatin-like-phospholipase-domain-containing-protein-3-pnpla3-gene-and-hepatocellular-carcinoma-susceptibility-evidence-from-case-control-studies
#18
REVIEW
Jian-Feng Li, En-Qi Zheng, Ming Xie
OBJECTIVES: Numerous studies have investigated the association between patatin-like phospholipase domain-containing protein-3 (PNPLA3) rs738409 C > G polymorphism and the risk of hepatocellular carcinoma (HCC). However, the results are conflicting and inconclusive among different populations. Thus, a meta-analysis was performed to resolve this inconsistency. METHODS: Potentially related studies were investigated in PubMed, Cochrane Library, EMBASE, and Chinese Biomedical Database (CBM) up to June 12, 2018...
November 4, 2018: Gene
https://www.readbyqxmd.com/read/30399428/genome-wide-association-and-gene-environment-interaction-study-identifies-variants-in-aldh2-associated-with-serum-ferritin-in-a-chinese-population
#19
Yuting Tao, Xiaoliang Huang, Yuanliang Xie, Xianguo Zhou, Xiaoli He, Shaomei Tang, Ming Liao, Yang Chen, Aihua Tan, Yingchun Chen, Qiuyan Wang, Zengnan Mo
Ferritin is not only a biomarker of total iron status and systemic inflammation but is also associated with metabolic disorders. A number of genetic variations have been identified to affect serum ferritin, but there is limited understanding of the genetic variations in serum ferritin. To evaluate the relationships among genetic variations, metabolism and ferritin, we performed a secondary analysis of our previous genome-wide association study of ferritin. After adjusting for population stratification and age, the rs671 in ALDH2 was significantly associated with ferritin concentrations (P-combined = 2...
November 3, 2018: Gene
https://www.readbyqxmd.com/read/30399427/meg2-inhibits-the-growth-and-metastasis-of-hepatocellular-carcinoma-by-inhibiting-akt-pathway
#20
Dongjian Ying, Yi Ruan, Xinhua Zhou
MEG2 was recently found to have important functions in human cancers. However, the expression status and biological functions of MEG2 in hepatocellular carcinoma (HCC) remain unknown. In this study, we demonstrated that MEG2 expression was reduced in HCC tissues and cell lines using qRT-PCR, western blot and immunohistochemical staining. Decreased MEG2 expression predicted unfavorable clinical features and decreased overall survival and disease-free survival of HCC patients. In vitro functional assays showed that overexpression of MEG2 inhibited the cell viability, migration and invasion of HCCLM3 cells while MEG2 knockdown promoted these biological functions of Hep3B cells...
November 3, 2018: Gene
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