A randomized trial of danazol pretreatment prior to endometrial resection.

OBJECTIVES: To assess the effect of danazol pretreatment in women undergoing endometrial resection for dysfunctional uterine bleeding.

STUDY DESIGN: A total of 132 patients were randomly divided into danazol pretreated and untreated groups. Endometrial resection was carried out using a 24Fr cutting wire loop electrode and 1.5% glycine as the distension media. Patients were followed-up for 6 years. The t-test and Chi-square tests were used to test differences between the two groups.

RESULTS: The mean endometrial thickness, fluid used, fluid deficit, weight of resected tissue and duration of surgery were significantly greater in the unprepared group. Over 70% of patients in both the groups achieved amenorrhoea or spotting. Two (1.5%) patients underwent a repeat procedure and two (1.5%) others a hysterectomy, while the rest had hypomenorrhoea. The perimenstrual symptoms also showed significant improvement. No statistically significant difference was found in the outcomes of the two groups.

CONCLUSION: Endometrial resection is an effective alternative to hysterectomy and pretreatment of the endometrium is not necessary for good outcomes.