Oncology in neuroimmunomodulation. What progress has been made?

In 1987 in Dubrovnik, Yugoslavia, N.H. Spector named a new discipline: Neuroimmunomodulation. R. Ader called this new discipline psychoneuroimmunomodulation when the major emphysis was on its behavioral aspects. Neuroimmunomodulation (NIM) is devoted to the study of the interactions at different morphologic and functional levels among the immune, nervous, and endocrine systems. In fact, this science is the modern manifestation of an old science: in the words of B.D. Jankovic (1987), "Neuroimmunomodulation is a modern reflection in neurosciences and immunosciences of the ideas and experience of philosophers and ingenious observers of ancient Egypt, Greece, China, India, and other civilizations that the mind is involved in the defense against diseases." Twelve years ago NIM was regarded by many conventional scientists almost as a form of witchcraft. Today it may be the fastest growing area of biomedical science research in the world. Important clinical applications will not be far behind. NIM research has also progressed in the field of oncology research. Topics such as treatment of hormone-dependent cancer with analogues of hypothalamic hormones, the role of opioids and T cells in cancer, stress-cancer-immune connections, the anticancer role of melatonin and cytokines, immunotherapy of cancer, and the role of psychotherapy in cancer patients represent some lines of research that have been or are being investigated by scientists. Some areas remain to be thoroughly investigated such as the influence of physical exercise (sports), music (classical or modern), and/or relaxation techniques (e.g. yoga) on the development of human cancer. This paper reviews the role of NIM in oncology and provides some perspectives for further research and development of clinical applications.