Effect of Vitamin E on Diabetic Nephropathy: A Meta-Analysis.

BACKGROUND: Diabetes nephropathy has always been one of the main causes of chronic kidney disease and end-stage kidney disease (ESRD), and diabetes nephropathy accounts for about 40% of ESRD cases. Vitamin E can effectively reduce urinary microalbumin, urinary albumin excretion rate and serum nitric oxide level in patients with type 2 diabetes nephropathy.

METHODS: The computer retrieves four databases to obtain controlled trials on the effects of vitamin E in patients with diabetic nephropathy. After a rigorous literature quality evaluation, data analysis was performed using Stata software. Study Design Type Published controlled trials on the effects of vitamin E in patients with diabetic nephropathy. However, the animal trials were excluded. The intervention group received vitamin E in the treatment of patients with diabetic nephropathy, and the control group received a placebo in the treatment of patients with diabetic nephropathy. Outcome indicators patients with diabetic nephropathy; According to research, the assessment tools for the effects of vitamin E in patients with diabetic nephropathy are: (1) HbA1c (Glycated hemoglobin,%); (2) EGFR (mL/min 1.73 m2); (3) Serum creatinine (μmol/L); (4) Urea (mmol/L); (5) Systolic BP (mmHg); (6) Diastolic BP (mmHg).

RESULTS: 5 studies were ultimately included in this meta-analysis. 5 studies reported the glycosylated hemoglobin (HbA1c) of the test group and the control group, which was significantly lower (SMD: -0.17; 95% Cl: -0.26,-0.07; P < .01) than the control group. Meta-analysis showed that the Serum creatinine of the test group was also significantly lower (SMD: -11.20; 95% Cl: -12.89,-9.51; P < .01) than the control group. EGFR of the test group had no significant statistical significance (SMD: -0.90; 95% Cl: -13.30,11.49; P = .886) than the control group. Meta-analysis showed that the urea of the test group had no significant statistical significance(SMD: -0.57; 95% Cl: -1.58,0.45; P = .275). The systolic BP (SMD: -3.95; 95% Cl: -9.79,1.88; P = .184) and Diastolic BP (SMD: 0.26; 95% Cl: -0.75,1.27; P = .617) are also consistent with the group.

CONCLUSION: The results of this study suggest that vitamin E may be effective on in patients with diabetic nephropathy, as evidenced by HbA1c and Serum creatinine, and the above conclusions need to be verified by more high-quality studies.