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Orthostatic hypotension promotes the progression from mild cognitive impairment to dementia in type 2 diabetes mellitus.
Journal of Clinical Endocrinology and Metabolism 2024 January 3
INTRODUCTION: In type 2 diabetes mellitus (T2DM), orthostatic hypotension (OH) was associated with cognition, but the mechanisms governing the link between OH and cognition are still unclear.
METHODS: We recruited T2DM with mild cognitive impairment (MCI) subjects, collected general healthy information and blood samples. Complement proteins of astrocyte-derived exosomes isolated and Alzheimer's disease (AD) biomarkers of neuronal cell-derived exosomes isolated were quantified by ELISA. Cognitive assessments were performed at patient enrollment and follow-up.
RESULTS: Mediation analysis showed that the influence of OH on cognition in T2DM was partly mediated by baseline AD biomarkers and complement proteins. Cox proportional hazards regression proved OH group had a higher risk of developing dementia compared to T2DM without OH group.
DISCUSSION: In T2DM with MCI patients, AD biomarkers and complement proteins mediate the effects of OH on cognitive impairment and OH may be a risk factor of progression from MCI to dementia in T2DM.
METHODS: We recruited T2DM with mild cognitive impairment (MCI) subjects, collected general healthy information and blood samples. Complement proteins of astrocyte-derived exosomes isolated and Alzheimer's disease (AD) biomarkers of neuronal cell-derived exosomes isolated were quantified by ELISA. Cognitive assessments were performed at patient enrollment and follow-up.
RESULTS: Mediation analysis showed that the influence of OH on cognition in T2DM was partly mediated by baseline AD biomarkers and complement proteins. Cox proportional hazards regression proved OH group had a higher risk of developing dementia compared to T2DM without OH group.
DISCUSSION: In T2DM with MCI patients, AD biomarkers and complement proteins mediate the effects of OH on cognitive impairment and OH may be a risk factor of progression from MCI to dementia in T2DM.
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