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Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America

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https://www.readbyqxmd.com/read/28430999/repurposing-quantiferon-for-detection-of-neutralizing-ifn-%C3%AE-autoantibodies-in-patients-with-nontuberculous-mycobacterial-infections
#1
Isabelle Suárez, Clara Lehmann, Henning Gruell, Jessica Graeb, Matthias Kochanek, Gerd Fätkenheuer, Georg Plum, Annelies van Wengen, Esther van de Vosse, Pia Hartmann, Leif G Hanitsch, Jan Rybniker
Nontuberculous mycobacterial (NTM) infections due to autoantibodies targeting IFN-γ are an emerging medical problem. However, case finding is hampered due to highly complex diagnostic procedures not available in routine laboratories. We show that QuantiFERON assays can be exploited as a simple screening tool that may facilitate adequate and timely treatment.
April 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28431103/reply-to-skowronski-and-chambers
#2
Allen C Cheng, Kristine K Macartney, Grant W Waterer, Tom Kotsimbos, Paul M Kelly, Christopher C Blyth
No abstract text is available yet for this article.
April 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28430899/mycobacterium-chimaera-infections-associated-with-contaminated-heater-cooler-devices-for-cardiac-surgery-outbreak-management
#3
Alexandre R Marra, Daniel J Diekema, Michael B Edmond
This paper focuses on assisting hospitals in establishing a rapid response for identification, notification, and evaluation of exposed patients, and management of HCDs with regards to placement and containment, environmental culturing, and disinfection.The global outbreak of Mycobacteriurm chimaera infections associated with heater-cooler devices (HCDs) presents several important, unique challenges for the infection prevention community. The primary focus of this paper is to assist hospitals in establishing a rapid response for identification, notification, and evaluation of exposed patients, and management of HCDs with regards to placement and containment, environmental culturing, and disinfection...
April 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28430894/pooling-and-the-potential-dilution-of-repeat-influenza-vaccination-effects
#4
Danuta M Skowronski, Catharine Chambers
No abstract text is available yet for this article.
April 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28430889/accuracy-of-diagnostic-tests-for-schistosoma-mansoni-infection-in-asymptomatic-eritrean-refugees-serology-and-poc-cca-against-stool-microscopy
#5
Afona Chernet, Kerstin Kling, Véronique Sydow, Esther Kuenzli, Christoph Hatz, Jürg Utzinger, Lisette van Lieshout, Hanspeter Marti, Niklaus D Labhardt, Andreas Neumayr
Background: The unprecedented increase in number of African refugees arriving in Europe is confronting clinicians and general practitioners with the question of whether or not and how to screen migrants from endemic regions for Schistosoma mansoni infection. Methods: We assessed the accuracy of three different diagnostic tests for S.mansoni infection (stool microscopy [samples prepared by sedimentation technique], serology, and point-of-care circulating cathodic antigen [POC-CCA] urine cassette test) in 107 newly arrived asymptomatic Eritrean refugees in Switzerland...
April 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28430880/cerebral-abscess-associated-with-odontogenic-bacteremias-hypoxemia-and-iron-loading-in-immunocompetent-patients-with-right-to-left-shunting-through-pulmonary-arteriovenous-malformations
#6
E J Boother, S Brownlow, H C Tighe, K B Bamford, J E Jackson, C L Shovlin
Background: Cerebral abscess is a recognised complication of pulmonary arteriovenous malformations (PAVMs) that allow systemic venous blood to bypass the pulmonary capillary bed through anatomic right-to-left shunts. Broader implications and mechanisms remain poorly explored. Methods: Between June 2005 and December 2016, at a single institution, 445 consecutive adult patients with CT-scan confirmed PAVMs (including 403 (90.5%) with hereditary haemorrhagic telangiectasia) were recruited to a prospective series...
April 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28419350/epidemiology-of-meningitis-and-encephalitis-in-the-united-states-from-2011-2014
#7
Rodrigo Hasbun, Ning Rosenthal, J M Balada-Llasat, Jessica Chung, Steve Duff, Samuel Bozzette, Louise Zimmer, Christine C Ginocchio
Background: Large epidemiological studies evaluating the etiologies, management decisions and outcomes of adults with meningitis and encephalitis in the United States (US) are lacking. Methods: Adult patients (≥18 years) with meningitis or encephalitis by ICD-9 codes available in the Premier Healthcare Database during 2011-2014 were analyzed. Results: A total of 26,429 patients with meningitis or encephalitis were identified. The median age was 43 years; 53% were female...
April 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28419259/adjunctive-corticosteroid-therapy-in-the-treatment-of-coccidioidal-meningitis
#8
George R Thompson, Janis Blair, Sharon Wang, Robert Bercovitch, Michael Bolaris, Dane Van Den Akker, Rodrigo Lopez, Arash Heidari, Antonino Catanzaro, Jose Cadena, Peter Chin-Hong, Brad Spellberg, Royce Johnson
Coccidioidal meningitis (CM) has high morbidity, and adjunctive measures to improve outcomes are needed. Using an established multicenter retrospective cohort study of CM (N=221), we found patients receiving adjunctive corticosteroids had a significant reduction in secondary cerebrovascular events (P=0.0049). Those with CM-associated cerebrovascular events (8%) may benefit from short-term corticosteroids.
April 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28419213/risks-factors-for-congenital-cmv-infection-following-primary-and-non-primary-maternal-infection-a-prospective-neonatal-screening-study-using-pcr-in-saliva
#9
Marianne Leruez-Ville, Jean-François Magny, Sophie Couderc, Christine Pichon, Marine Parodi, Laurence Bussières, Tiffany Guilleminot, Idir Ghout, Yves Ville
Background: The design of diagnostic and preventive strategies have been prevented by gaps in knowledge of the epidemiology of congenital CMV (cCMV) with the type of maternal infection as well as the lack of large-scale neonatal screening tools. Methods: 11,715 consecutive newborns were screened for cCMV by PCR in saliva. Prevalence, type of maternal infection, socio-demographic, obstetrical and serological data were analyzed. Results: Positive predictive value of CMV PCR in saliva was 59%, false positive results were associated with lower viral loads (p<0...
April 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28419202/genomic-characterization-of-usa300-mrsa-to-evaluate-intraclass-transmission-and-recurrence-of-ssti-among-high-risk-military-trainees
#10
Eugene V Millar, Gregory K Rice, Emad M Elassal, Carey D Schlett, Jason W Bennett, Cassie L Redden, Deepika Mor, Natasha N Law, David R Tribble, Theron Hamilton, Michael W Ellis, Kimberly A Bishop-Lilly
Background.: Military trainees are at increased risk for methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infection (SSTI). Whole genome sequencing (WGS) can refine our understanding of MRSA transmission and microevolution in congregate settings. Methods.: We conducted a prospective case-control study of SSTI among US Army Infantry trainees at Fort Benning, GA from July 2012-December 2014. We identified clusters of USA300 MRSA SSTI within select training classes and performed WGS on clinical isolates...
April 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28419200/switching-to-efavirenz-versus-remaining-on-ritonavir-boosted-lopinavir-in-hiv-infected-children-exposed-to-nevirapine-long-term-outcomes-of-a-randomized-trial
#11
Pamela M Murnane, Renate Strehlau, Stephanie Shiau, Faeezah Patel, Ndileke Mbete, Gillian Hunt, Elaine J Abrams, Ashraf Coovadia, Louise Kuhn
Background: We previously demonstrated the non-inferiority of switching to efavirenz (EFV) versus remaining on ritonavir-boosted lopinavir (LPV/r) for virologic control in HIV-infected children exposed to nevirapine (NVP) for prevention of mother-to-child transmission. Here we assess outcomes up to four years post-randomization. Methods: From 2010-2013, 298 NVP-exposed HIV-infected children ≥3 years of age were randomized to switch to EFV or remain on LPV/r in Johannesburg, South Africa (Clinicaltrials...
April 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28419238/antiretroviral-therapy-initiation-and-changes-in-self-reported-depression
#12
Ellen F Eaton, Ronnie M Gravett, Ashutosh R Tamhane, Michael J Mugavero
In this retrospective study of treatment-naive PLWH initiating antiretroviral therapy, the score for the depression scale of the Patient Health Questionnaire (PHQ-9) was significantly higher at baseline (median, 6.0; interquartile range, 2-11) than at 12 months (3.0; 0-8; P < .001). Baseline depression and lack of insurance are associated with 12-month depression, but receipt of efavirenz-based antiretroviral therapy is not.
April 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28419222/reply-to-manian-et-al
#13
Jason M Pogue, Bhagyashri Navalkele, Keith S Kaye
No abstract text is available yet for this article.
April 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28419215/reply-to-allan-blitz-and-klausner
#14
Michael Gaisa, Keith Sigel, Judith Aberg, Michelle Cespedes
No abstract text is available yet for this article.
April 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28419214/the-evidence-that-increased-syphilis-testing-controls-syphilis-is-compelling-what-is-needed-to-act
#15
Jeffrey D Klausner
No abstract text is available yet for this article.
April 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28419210/dasatinib-use-and-risk-of-cytomegalovirus-reactivation-after-allogeneic-hematopoietic-cell-transplantation
#16
Daniel P Prestes, Esther Arbona, Alexandra Nevett-Fernandez, Ann E Woolley, Vincent T Ho, Sophia Koo, Lindsey R Baden, John Koreth, Sarah P Hammond, Nicolas C Issa, Francisco M Marty
Viral infections have been reported with dasatinib use, but its cytomegalovirus risk after hematopoietic-cell transplantation (HCT) is not known. We found that post-HCT dasatinib use increased the risk of cytomegalovirus reactivation (adjusted hazard ratio 7.65; 95% CI, 1.84-31.7), controlling for acute graft-versus-host disease, in 109 patients with Philadelphia-chromosome-positive malignancies.
April 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28419204/immune-serum-from-sabin-inactivated-poliovirus-vaccine-immunization-neutralizes-multiple-individual-wild-and-vaccine-derived-polioviruses
#17
Mingbo Sun, Changgui Li, Wenbo Xu, Guoyang Liao, Rongcheng Li, Jian Zhou, Yanping Li, Wei Cai, Dongmei Yan, Yanchun Che, Zhifang Ying, Jianfeng Wang, Huijuan Yang, Yan Ma, Lei Ma, Guang Ji, Li Shi, Shude Jiang, Qihan Li
Background.: A Sabin strain-based inactivated poliomyelitis vaccine (Sabin-IPV) is the rational option for completely eradicating poliovirus transmission. The neutralizing capacity of Sabin-IPV immune serum to different strains of poliovirus is a key indicator of the clinical protective efficacy of this vaccine. Methods.: Sera collected from 500 infants enrolled in a randomized, blinded, positive control, phase 2 clinical trial were randomly divided into 5 groups: Groups A, B, and C received high, medium, and low doses, respectively, of Sabin-IPV, while groups D and E received trivalent oral polio vaccine and Salk strain-based IPV, respectively, all on the same schedule...
April 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28419199/should-we-revisit-the-nephrotoxic-potential-of-piperacillin-tazobactam-as-well
#18
Farrin A Manian
No abstract text is available yet for this article.
April 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28419198/increased-syphilis-testing-of-men-who-have-sex-with-men-greater-detection-of-asymptomatic-early-syphilis-and-relative-reduction-in-secondary-syphilis
#19
Eric P F Chow, Denton Callander, Christopher K Fairley, Lei Zhang, Basil Donovan, Rebecca Guy, David A Lewis, Margaret Hellard, Phillip Read, Alison Ward, Marcus Y Chen
Background: Syphilis rates have increased markedly among men who have sex with men (MSM) in many countries. This study examined trends in syphilis testing and detection of early syphilis among MSM in Australia. Methods: Serial cross-sectional analyses on syphilis testing and diagnoses among MSM attending a national sentinel network of 46 sexual health clinics in Australia between 2007 and 2014. Results: There were 359,313 clinic visits included in the analysis, with 32% of clinic visits for HIV-positive MSM...
April 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28419196/the-need-for-outcome-studies-prior-to-large-scale-implementation-of-screening-for-anal-cancer
#20
Lao-Tzu Allan-Blitz, Jeffrey D Klausner
No abstract text is available yet for this article.
April 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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