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Journal of Clinical Endocrinology and Metabolism

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https://www.readbyqxmd.com/read/29788364/effectiveness-of-prenatal-vitamin-d-deficiency-screening-and-treatment-program-a-stratified-randomized-field-trial
#1
Maryam Rostami, Fahimeh Ramezani Tehrani, Masoumeh Simbar, Razieh Bidhendi Yarandi, Sonia Minooee, Bruce W Hollis, Farhad Hosseinpanah
Context: Despite evidence on the association between hypovitaminosis D and adverse pregnancy outcomes and the positive impact of vitamin D supplementation, no evidence exists supporting a universal screening program in pregnancy as part of a routine prenatal care. Objective: We aimed at determining the effectiveness of a prenatal screening program on optimizing 25-hydroxyvitamin D(25(OH)D) levels and preventing pregnancy complications. Also, to identify a safe regimen, we compared several regimens in a subgroup of vitamin D deficient pregnant women...
May 18, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29788255/reproductive-hormones-and-subclinical-cardiovascular-disease-in-midlife-women
#2
Rebecca C Thurston, Shalender Bhasin, Yuefang Chang, Emma Barinas Mitchell, Karen A Matthews, Ravi Jasuja, Nanette Santoro
Context: Reproductive hormones are understood to be important to the pathophysiology of cardiovascular disease (CVD) in women. However, standard estradiol (E2) and testosterone (T) assays lack sensitivity at the levels of postmenopausal women. Objective: Investigate relations of mass spectrometry-assessed estrone (E1), estradiol (E2), and testosterone (T), and sex hormone binding globulin (SHBG) and subclinical CVD in women. Design, Setting, Participants: 304 peri- and postmenopausal women, aged 40-60 years, and free of clinical CVD underwent subclinical CVD measurements...
May 18, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29788090/disease-burden-and-outcome-in-pediatric-and-young-adults-with-concurrent-graves-disease-and-differentiated-thyroid-carcinoma
#3
Suzanne P MacFarland, Andrew J Bauer, N Scott Adzick, Lea F Surrey, Jessica Noyes, Ken Kazahaya, Sogol Mostoufi-Moab
Context: Adults with differentiated thyroid carcinoma (DTC) and Graves Disease (GD) demonstrate a greater reported disease burden and aggressive DTC behavior. To date, no studies have examined the impact and long-term outcome of concurrent GD and DTC (GD-DTC) in pediatric and young adults. Design: Single institution, retrospective longitudinal cohort study between 1997-2016. Participants: 139 pediatric and young adults with DTC, diagnosed at median age 15 (range 5-23) years compared to 12 GD-DTC patients, median age 18 (range 12-20) years...
May 18, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29788483/persisting-embryonal-infundibular-recess-peir-two-case-reports-and-systematic-literature-review
#4
Francesco Belotti, Isabella Lupi, Mirco Cosottini, Claudia Ambrosi, Roberto Gasparotti, Fausto Bogazzi, Marco M Fontanella, Francesco Doglietto
Context: The persisting embryonal infundibular recess (PEIR) is a rare anomaly of the floor of the third ventricle with a debated pathogenesis. It can be a cause of misdiagnosis in case of cystic lesions of the sellar and suprasellar area. Objective: To describe two recently evaluated cases and provide a systematic literature review. Evidence acquisition and Case Descriptions: PEIR has been previously reported in 6 adult patients. As in some cases it was associated to hydrocephalus and/or empty sella, a possible role of altered intracranial pressure in PEIR formation has been postulated...
May 16, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29788444/norepinephrine-and-thyroxine-are-predictors-of-fat-mass-gain-in-humans-with-cold-induced-brown-adipose-tissue-activation
#5
Brittany Begaye, Paolo Piaggi, Marie S Thearle, Kaitlyn Haskie, Mary Walter, Mathias Schlögl, Susan Bonfiglio, Jonathan Krakoff, Karyne L Vinales
Context: In healthy adults with detectable cold-induced brown fat activation (CIBA), the relationships between sympathetic nervous system (SNS) or thyroid activity during energy balance (EBL) with CIBA and body composition change are undetermined. Objective: To investigate the relationships between CIBA and thermoneutral catecholamines and thyroid hormones measured during EBL and to determine if CIBA, catecholamines, or thyroid hormones predict body composition changes...
May 16, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29788436/s-25ohd-is-associated-with-hand-grip-strength-and-myopathy-at-five-years-in-girls-an-odense-child-cohort-study
#6
Rada Faris Al-Jwadi, Eva Jespersen, Christine Dalgård, Niels Bilenberg, Henrik Thybo Christesen
Context: Severe vitamin D deficiency may lead to myopathy in adults. Little is known about vitamin D and muscle strength in children. Objective: To test whether hand grip strength (HGS) in 5-year-old-children associates with serum 25-hydroxyvitamin D (s-25OHD) from pregnancy to five years. Methods: Observational study in the population-based Odense Child Cohort, Denmark. At five years, anthropometrics, body fat percentage by skin fold measurements and HGS were obtained (n=881)...
May 16, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29788285/altered-asparagine-and-glutamate-homeostasis-precede-coronary-artery-disease-and-type-2-diabetes
#7
Filip Ottosson, Einar Smith, Olle Melander, Céline Fernandez
Context: Type 2 diabetes (T2DM) is accompanied by an increased risk of coronary artery disease (CAD), but the overlapping metabolic disturbances preceding both diseases are insufficiently described. Objective: We hypothesized that alterations in metabolism occur years before clinical manifestation of T2DM and CAD and that these alterations are reflected in the plasma metabolome. We thus aimed to identify plasma metabolites that predict future T2DM and CAD. Design: Using targeted liquid chromatography-mass spectrometry (LC-MS), 35 plasma metabolites (amino acid metabolites and acylcarnitines) were quantified in 1049 individuals, free from CAD and diabetes, drawn from a population sample of 5386 in the Malmö Preventive Project (mean age 69...
May 16, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29788217/treatment-free-survival-in-patients-with-differentiated-thyroid-cancer
#8
Mousumi Banerjee, David Reyes-Gastelum, Megan R Haymart
Purpose: Cancer recurrence is a primary concern for patients with differentiated thyroid cancer; however, population-level data on recurrent or persistent disease does not currently exist. The objective of this study was to determine treated recurrent or persistent thyroid cancer using a population-based registry, identify correlates of poor treatment-free survival, and define prognostic groups for treatment-free survival. Methods: In this population-based study, we evaluated treatment-free survival in 9,273 patients from Surveillance, Epidemiology and End Results Program - Medicare diagnosed with differentiated thyroid cancer between 1998 and 2012...
May 16, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29788189/progression-of-mineral-ion-abnormalities-in-patients-with-jansen-s-metaphyseal-chondrodysplasia
#9
Hiroshi Saito, Hiroshi Noda, Philippe Gatault, Detlef Böckenhauer, Kah Yin Loke, Olaf Hiort, Caroline Silve, Erin Sharwood, Regina Matsunaga Martin, Michael J Dillon, David Gillis, Mark Harris, Sudhaker D Rao, Richard M Pauli, Thomas J Gardella, Harald Jüppner
Context: Five different activating PTH/PTHrP receptor (PTHR1) mutations have been reported as causes of Jansen metaphyseal chondrodysplasia (JMC), a rare disorder characterized by severe growth plate abnormalities and PTH-independent hypercalcemia. Objectives: Assess the natural history of clinical and laboratory findings in twenty-four JMC patients and characterize the disease-causing mutant receptors in vitro. Patients and Methods: The H223R mutation occurred in 18 patients...
May 16, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29788123/gastric-emptying-and-the-personalized-management-of-type-1-diabetes
#10
Chinmay S Marathe, Christopher K Rayner, Tongzhi Wu, Karen L Jones, Michael Horowitz
No abstract text is available yet for this article.
May 16, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29771348/letter-to-the-editor-effects-of-long-term-denosumab-on-bone-histomorphometry-and-mineralization-in-women-with-postmenopausal-osteoporosis
#11
Toshihiro Sugiyama
No abstract text is available yet for this article.
May 15, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29767754/mid-luteal-progesterone-a-marker-of-treatment-outcomes-in-couples-with-unexplained-infertility
#12
Karl R Hansen, Esther Eisenberg, Valerie Baker, Micah J Hill, Sixia Chen, Sara Talken, Michael P Diamond, Richard S Legro, Christos Coutifaris, Ruben Alvero, Randal D Robinson, Peter Casson, Gregory M Christman, Nanette Santoro, Heping Zhang, Robert A Wild
Context: Adequate luteal phase progesterone exposure is necessary to induce endometrial changes required for a successful pregnancy outcome. The relationship between low mid-luteal progesterone concentration and the outcome of live birth in ovarian stimulation with intrauterine insemination (OS-IUI) treatments is not defined. Objective: To determine the level of mid-luteal progesterone portending a low chance of live birth following OS-IUI in couples with unexplained infertility...
May 14, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29762737/postnatal-lifestyle-intervention-for-overweight-women-with-previous-gestational-diabetes-a-randomized-controlled-trial
#13
Valerie A Holmes, Claire R Draffin, Chris C Patterson, Loraine Francis, Joanne Irwin, Mae McConnell, Brid Farrell, Sarah F Brennan, Oonagh McSorley, Amy C Wotherspoon, Mark Davies, David R McCance
Background: Gestational diabetes mellitus (GDM) is associated with a 7-fold increased lifetime risk of type 2 diabetes. Excessive gestational weight gain and postpartum weight retention are established predictors of long-term obesity. Objective: To determine the impact of a postnatal lifestyle intervention programme for overweight women with previous gestational diabetes mellitus (PAIGE). Design: Postnatal overweight women with previous GDM participated in a multi-center randomized controlled trial between June 2013 and December 2014...
May 11, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29757443/impact-of-genetic-polymorphism-in-the-%C3%AE-%C3%A2-receptor-gene-on-risk-of-severe-hypoglycemia-in-patients-with-type-1-diabetes
#14
Kim Zillo Rokamp, Niels Vidiendal Olsen, Louise Færch, Peter Lommer Kristensen, Birger Thorsteinsson, Ulrik Pedersen-Bjergaard
Context and Objective: Severe hypoglycemic events are unevenly distributed in subjects with type 1 diabetes making a genetic influence probable. The adrenergic beta-2-receptor gene (ADRB2) has several common polymorphisms of which the Arg16 allele is associated with receptor down-regulation and reduced agonist-mediated endogenous glucose production. We tested the hypothesis that the Arg16 variant is associated with severe hypoglycaemia. Method: A cohort of 311 subjects with type 1 diabetes reported severe hypoglycemic events retrospectively in a validated questionnaire...
May 10, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29757399/associations-of-dehydroepiandrosterone-sulfate-with-cardiometabolic-risk-factors-in-prepubertal-children
#15
Aino Mäntyselkä, Virpi Lindi, Anna Viitasalo, Aino-Maija Eloranta, Jyrki Ågren, Sari Väisänen, Raimo Voutilainen, Tomi Laitinen, Timo A Lakka, Jarmo Jääskeläinen
Context: Premature adrenarche (PA) has been associated with overweight and insulin resistance, but the associations of serum dehydroepiandrosterone sulfate (DHEAS) concentration with other cardiometabolic risk factors are uncertain. Objective: To examine the associations of serum DHEAS concentration with several cardiometabolic risk factors in children. Design: Cross-sectional data from the Physical Activity and Nutrition in Children Study...
May 10, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29757392/thyroid-function-in-early-pregnancy-child-iq-and-autistic-traits-a-meta-analysis-of-individual-participant-data
#16
Deborah Levie, Tim I M Korevaar, Sarah C Bath, Albert Dalmau-Bueno, Mario Murcia, Mercedes Espada, Mariana Dineva, Jesús M Ibarluzea, Jordi Sunyer, Henning Tiemeier, Marisa Rebagliato, Margaret P Rayman, Robin P Peeters, Mònica Guxens
Context: Low maternal free thyroxine (FT4) has been associated with poor child neurodevelopment in some single-centre studies. Evidence remains scarce for potential adverse effects of high FT4 and whether associations differ in countries with a different iodine status. Objective: To assess the association of maternal thyroid function in early pregnancy with child neurodevelopment in countries with a different iodine status. Design, Setting and Participants: Meta-analysis of individual-participant data compromising 9,036 mother-child pairs from three prospective population-based birth cohorts: INMA (Spain), Generation R (The Netherlands) and ALSPAC (United Kingdom)...
May 10, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29750416/serum-25-hydroxyvitamin-d-plasma-lipids-and-associated-gene-variants-in-prepubertal-children
#17
Sonja Soininen, Aino-Maija Eloranta, Anna Viitasalo, Geneviève Dion, Arja Erkkilä, Virpi Sidoroff, Virpi Lindi, Anitta Mahonen, Timo A Lakka
Context: The associations of serum 25-hydroxyvitamin D (25(OH)D) with plasma lipids remain controversial in children. Objective: To examine the associations and interactions of 25(OH)D and related gene variants with lipids in children. Design: Cross-sectional. Setting: City of Kuopio, Finland. Participants: Population sample of 419 prepubertal Caucasian children aged 6-8 years. Main Outcome Measures: 25(OH)D, total cholesterol (TC), low-density lipoprotein cholesterol (LDLC), high-density lipoprotein cholesterol (HDLC), and triglycerides...
May 9, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29750414/glucose-dependent-insulinotropic-polypeptide-increases-blood-flow-in-adipose-tissue-of-humans-by-recruiting-capillaries
#18
Meena Asmar, Ali Asmar, Lene Simonsen, Jens Juul Holst, Jens Bülow
Context and objektive: Glucose-dependent insulinotropic polypeptide (GIP) in combination with hyperinsulinemia increase blood flow and triglyceride clearance in subcutaneous abdominal adipose tissue in lean humans. The present experiments were performed to determine whether the increase may involve capillary recruitment. Design: Eight lean healthy volunteers were studied before and after 1-h infusion of GIP or saline during a hyperglycemic-hyperinsulinemic clamp, raising plasma glucose and insulin to postprandial levels...
May 9, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29741675/the-intestinotrophic-effects-of-glucagon-like-peptide-2-glp-2-in-relation-to-intestinal-neoplasia
#19
Adile Orhan, Ismail Gögenur, Hannelouise Kissow
Context: Glucagon-like peptide-2 (GLP-2) is a gastrointestinal hormone with intestinotrophic and anti-apoptotic effects. The hormone's therapeutic potential in intestinal diseases and relation to intestinal neoplasia have raised great interest among researchers. This paper reviews and discusses published experimental and clinical studies concerning the growth-stimulating and anti-apoptotic effects of GLP-2 in relation to intestinal neoplasia. Evidence acquisition: The data used in this narrative review were collected through literature research in PubMed using English keywords...
May 7, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29733361/clinical-excellence-in-endocrinology
#20
Howard B A Baum
Context: Clinical endocrinology is a field driven largely by numerical parameters. To achieve outstanding patient care, however, the clinical endocrinologist must employ a range of skills which can collectively be called "clinical excellence." While there is extensive published guidance regarding appropriate medical management and outcomes for endocrine patients, there has been no consensus definition of excellence in the field, nor any recommendation as to how excellence can be achieved...
May 3, 2018: Journal of Clinical Endocrinology and Metabolism
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