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Journal of Clinical Endocrinology and Metabolism

Christopher J Child, Alan G Zimmermann, George P Chrousos, Elisabeth Cummings, Cheri L Deal, Tomonobu Hasegawa, Nan Jia, Sarah Lawrence, Agnès Linglart, Sandro Loche, Mohamad Maghnie, Jacobo Pérez Sánchez, Michel Polak, Barbara Predieri, Annette Richter-Unruh, Ron G Rosenfeld, Diego Yeste, Tohru Yorifuji, Werner F Blum
Context: Safety concerns regarding premature mortality, diabetes, neoplasia and cerebrovascular disease in association with growth hormone (GH) therapy have been raised. Objective: To assess incidence of key safety outcomes. Design: Prospective, multinational, observational study (1999-2015). Setting: 22,311 GH-treated children from 827 investigative sites in 30 countries. Patients: Children with growth disorders...
September 13, 2018: Journal of Clinical Endocrinology and Metabolism
Anawin Sanguankeo, Sikarin Upala
No abstract text is available yet for this article.
September 13, 2018: Journal of Clinical Endocrinology and Metabolism
James R M Black, Stephen R Atkinson, Amal Singh, Joanne Evans, Rohini Sharma
Background: Peptide Receptor Radionuclide Therapy (PRRT) is an effective treatment for certain patients with metastatic neuroendocrine tumours (NETs). Tumour response is highly variable; no biomarker in clinical practice has been demonstrated to reliably predict outcome. The Inflammation-Based Index (IBI), derived from serum C-reactive protein and albumin levels, predicts survival and response to treatment in patients in a number of cancer types and was therefore explored in this setting...
September 13, 2018: Journal of Clinical Endocrinology and Metabolism
Karen Lindhardt Madsen, Nicolai Preisler, Jan Rasmussen, Gitte Hedermann, Jess Have Olesen, Allan Meldgaard Lund, John Vissing
Context: Primary Carnitine Deficiency (PCD) is an inborn error of fatty acid metabolism. PCD patients risk sudden heart failure upon fasting or illness if they are not treated with daily L-carnitine. Objective: To investigate energy metabolism during exercise in patients with PCD with and without L-carnitine treatment. Design: Interventional study. Setting: Hospital exercise laboratories and department of cardiology...
September 13, 2018: Journal of Clinical Endocrinology and Metabolism
Katherine G Lindeman, Logan B Greenblatt, Caroline Rourke, Mary L Bouxsein, Joel S Finkelstein, Elaine W Yu
Context: Bone health declines in the initial years after Roux-en-Y Gastric Bypass (RYGB), but long-term skeletal effects are unclear. Objective: To document longitudinal changes in bone mineral density (BMD) and microarchitecture 5 years after RYGB. Design, Setting, and Participants: Prospective 5-year observational study of 21 severely obese adults receiving RYGB at an academic medical center. Main Outcome Measures: Spine and hip areal BMD (aBMD) were measured by dual-energy X-ray absorptiometry (DXA) and trabecular volumetric BMD (vBMD) of the spine was assessed by quantitative computed tomography (QCT)...
September 13, 2018: Journal of Clinical Endocrinology and Metabolism
C E Stiles, E T Tetteh-Wayoe, J Bestwick, R P Steeds, W M Drake
Context: Cabergoline is first line treatment for most patients with lactotrope pituitary tumors and hyperprolactinemia. Its use at high-dose in Parkinson's disease has largely been abandoned, because of its association with the development of a characteristic restrictive cardiac valvulopathy. Whether similar valvular changes occur in patients receiving lower doses for treatment of hyperprolactinemia is unclear, although stringent regulatory recommendations for echocardiographic screening exist...
September 11, 2018: Journal of Clinical Endocrinology and Metabolism
Martin B Whyte, Fariba Shojaee-Moradie, Sharaf E Sharaf, Nicola C Jackson, Barbara Fielding, Roman Hovorka, Jeewaka Mendis, David Russell-Jones, A Margot Umpleby
Context: GLP-1 agonists control postprandial glucose and lipid excursion in type 2 diabetes; however the mechanism(s) are unclear. Objective: To determine the mechanism(s) of postprandial lipid and glucose control with lixisenatide (GLP-1 analogue) in type 2 diabetes. Design: Randomised, double-blind, cross-over study. Setting: Centre for Diabetes, Endocrinology, and Research, Royal Surrey County Hospital, Guildford, UK...
September 11, 2018: Journal of Clinical Endocrinology and Metabolism
Danielle A Swales, Leah A Grande, Deborah A Wing, Michelle Edelmann, Laura M Glynn, Curt Sandman, Roger Smith, Maria Bowman, Elysia Poggi Davis
Context: Antenatal corticosteroids commonly are administered to pregnant women at risk of delivering between 23 and 34 gestational weeks, providing crucial benefits to fetal lung maturation and reducing risk of neonatal morbidity and mortality. Corticosteroids are maximally efficacious for lung maturation when administered within 2 to 7 days of delivery. Accurately identifying the timing of preterm delivery is thus critical to ensure that antenatal corticosteroids are administered within a week of delivery and to avoid unnecessary administration to women who will deliver at term...
September 11, 2018: Journal of Clinical Endocrinology and Metabolism
Maria Nethander, Liesbeth Vandenput, Anna L Eriksson, Sara Windahl, Thomas Funck-Brentano, Claes Ohlsson
Context: Observational studies indicate that serum estradiol (E2) is more strongly associated with bone mineral density (BMD) than serum testosterone (T) while both E2 and T associate with fracture risk in men. Objective: To evaluate the possible causal effect of serum E2 and T on fracture risk in men. Design, Setting, and Participants: A Mendelian Randomization (MR) approach was undertaken using individual-level data of genotypes, BMD as estimated by quantitative ultrasound of the heel (eBMD), fractures (n=17,650), and relevant covariates of 175,583 unrelated men of European origin from the UK Biobank...
September 11, 2018: Journal of Clinical Endocrinology and Metabolism
Ilaria Capua, Alessia Mercalli, Aurora Romero-Tejeda, Matteo S Pizzuto, Samantha Kasloff, Valeria Sordi, Ilaria Marzinotto, Vito Lampasona, Elisa Vicenzi, Cristian De Battisti, Riccardo Bonfanti, Andrea Rigamonti, Calogero Terregino, Claudio Doglioni, Giovanni Cattoli, Lorenzo Piemonti
Context: Recent studies have suggested that influenza A virus (IAV) might be involved in the aetiology of diabetes. Objective and methods: To address this question, we tested the ability of H1N1 pandemic IAV to infect, replicate, and damage human beta cell/pancreatic islet in vitro, and to induce pancreatic damage and/or glucose metabolism alteration in chemical and autoimmune models of beta cell damage in vivo. Moreover, we looked for direct and/or indirect evidence of correlation between IAV infection and autoimmunity/diabetes in humans...
September 7, 2018: Journal of Clinical Endocrinology and Metabolism
Sarah Roels, Olivier R Costa, Sarah A Tersey, Geert Stangé, Dieter De Smet, Eric V Balti, Pieter Gillard, Bart Keymeulen, Zhidong Ling, Daniel G Pipeleers, Frans K Gorus, Raghavendra G Mirmira, Geert A Martens
Aim: several biomarkers were proposed to detect pancreatic beta cell destruction in vivo but were so far not compared for sensitivity and significance. Methods: we used islet transplantation as model to compare plasma concentrations of miR-375, GAD65 and (un)methylated insulin DNA, measured at subpicomolar sensitivity, to study their discharge kinetics, power for outcome prediction and detection of graft loss during follow-up. Results: at 60 min post-transplantation, GAD65 and miR-375 consistently showed near-equimolar and correlated increases, proportional to the number of implanted beta cells...
September 7, 2018: Journal of Clinical Endocrinology and Metabolism
Azimeh Izadi, Sara Ebrahimi, Shabnam Shirzai, Shiva Taghizadeh, Marziyeh Parizad, Laya Farzadi, Bahram Pourghassem Gargari
Context: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive age women. No study has examined the hormonal and metabolic effects of coenzyme Q10 and/or vitamin E in patients with PCOS. Objective: To evaluate the effects of coenzyme Q10 and/or vitamin E on glucose homeostasis parameters and reproductive hormones in women with PCOS. Design/Setting/Participants: Randomized double-blind placebo-controlled clinical trial among 86 women with PCOS...
September 7, 2018: Journal of Clinical Endocrinology and Metabolism
Ningjian Wang, Meng Lu, Chi Chen, Fangzhen Xia, Bing Han, Qin Li, Jing Cheng, Yi Chen, Chunfang Zhu, Michael D Jensen, Yingli Lu
Context: Previous epidemiological studies had inconsistent results regarding the relationship between blood lead level (BLL) and adiposity. Objective: We aimed to investigate the associations of BLL with body mass index (BMI) particularly using mendelian randomization analyses and examine the interaction between obesity-predisposing genes and BLL on the associations. Design and setting: 3,922 participants were enrolled from 16 sites in East China during 2014 based SPECT-China (ChiCTR-ECS-14005052, www...
September 7, 2018: Journal of Clinical Endocrinology and Metabolism
Felicia Gerst, Benjamin A Jaghutriz, Harald Staiger, Anke M Schulte, Estela Lorza-Gil, Gabriele Kaiser, Madhura Panse, Sieglinde Haug, Martin Heni, Monika Schütz, Mandy Stadion, Annette Schürmann, Flavia Marzetta, Mark Ibberson, Bence Sipos, Falko Fend, Thomas Fleming, Peter P Nawroth, Alfred Königsrainer, Silvio Nadalin, Silvia Wagner, Andreas Peter, Andreas Fritsche, Daniela Richter, Michele Solimena, Hans-Ulrich Häring, Susanne Ullrich, Robert Wagner
Context: Reduced beta-cell mass, impaired islet function and dedifferentiation are considered causal to development of hyperglycemia and type 2 diabetes. In human cohort studies, changes of islet cell-specific expression patterns have been associated with diabetes but not directly with in vivo insulin secretion. Objective: This study investigates alterations of islet gene expression and corresponding gene variants in the context of in vivo glycemic traits from the same patients...
September 7, 2018: Journal of Clinical Endocrinology and Metabolism
Sandra Loves, Lenneke van Groningen, Margreet Filius, Marja Mekking, Tom Brandon, Cees J Tack, Ad Hermus, Hans de Boer
Introduction: Obesity-related hyperinsulinism may impede lifestyle initiated weight loss. Aim: Proof-of-concept study to investigate the amplifying effects of diazoxide (DZX)-mediated insulin suppression on lifestyle-induced weight loss in non-diabetic, hyperinsulinemic obese men. Methods: 12-month study comprising an initial 6-month, double-blind trial followed by a partially de-blinded 6-month extension in obese men with a BMI of 30 - 37...
September 7, 2018: Journal of Clinical Endocrinology and Metabolism
Fahimeh Ramezani Tehrani, Sonia Minooee, Maryam Rostami, Razieh Bidhendi Yarandi, Farhad Hosseinpanah
No abstract text is available yet for this article.
September 6, 2018: Journal of Clinical Endocrinology and Metabolism
Alexis Shub, Elizabeth A McCarthy
No abstract text is available yet for this article.
September 6, 2018: Journal of Clinical Endocrinology and Metabolism
Giulia Sapuppo, Martina Tavarelli, Antonino Belfiore, Riccardo Vigneri, Gabriella Pellegriti
Context: Differentiated thyroid cancer (DTC) has an excellent prognosis, but up to 20% of DTC patients have disease events after initial treatment, indistinctly defined as persistent/recurrent disease. Objective: To evaluate the prevalence and outcome of "recurrent" (relapse after 12 months disease-free) compared to "persistent" disease (present ab initio since diagnosis). Design: Retrospective analysis of persistent/recurrent disease in DTC patients (1990-2016) with 6...
August 24, 2018: Journal of Clinical Endocrinology and Metabolism
Mary H Samuels, Irina Kolobova, Meike Niederhausen, Jonathan Q Purnell, Kathryn G Schuff
Background: It is unclear whether variations in thyroid status within and near the reference range affect energy expenditure, body mass, or body composition. Methods: 138 subjects treated with levothyroxine (L-T4) for hypothyroidism with normal TSH levels underwent measurement of total, resting, and physical activity energy expenditure; thermic effect of food; substrate oxidation; diet intake; and body composition. They were then assigned to receive an unchanged, higher or lower L-T4 dose in randomized, double-blind fashion, targeting one of three TSH ranges (0...
August 24, 2018: Journal of Clinical Endocrinology and Metabolism
Youichi Ohno, Masakatsu Sone, Nobuya Inagaki, Toshinari Yamasaki, Osamu Ogawa, Yoshiyu Takeda, Isao Kurihara, Hironobu Umakoshi, Takamasa Ichijo, Takuyuki Katabami, Norio Wada, Yoshihiro Ogawa, Takanobu Yoshimoto, Junji Kawashima, Minemori Watanabe, Yuichi Matsuda, Hiroki Kobayashi, Hirotaka Shibata, Shozo Miyauchi, Kohei Kamemura, Tomikazu Fukuoka, Koichi Yamamoto, Michio Otsuki, Tomoko Suzuki, Mitsuhide Naruse
CONTEXT: Recently, the relationship between primary aldosteronism (PA) and various metabolic disorders including obesity, diabetes mellitus, and dyslipidemia has been discussed. In PA, however, aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA) have different etiologies. OBJECTIVE: Our objectives were to clarify differences in obesity and metabolic disorders between APA and IHA, and to gain new insight in the pathogenesis of IHA. DESIGN, SETTING, AND PARTICIPANTS: This is a retrospective cross-sectional study...
August 24, 2018: Journal of Clinical Endocrinology and Metabolism
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