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Journal of Clinical Endocrinology and Metabolism

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https://www.readbyqxmd.com/read/28009530/maternal-cortisol-during-pregnancy-and-infant-adiposity-a-prospective-investigation
#1
Sonja Entringer, Claudia Buss, Jerod M Rasmussen, Karen Lindsay, Daniel L Gillen, Dan M Cooper, Pathik D Wadhwa
CONTEXT: Glucocorticoids play a key role during intrauterine development in cellular growth and differentiation. Evidence suggests that exposure to inappropriate concentrations of glucocorticoids during sensitive developmental periods may produce alterations in physiological systems that impact obesity risk. OBJECTIVE: To elucidate the magnitude and stage-of-gestation specific association of maternal cortisol concentrations during pregnancy with infant adiposity...
December 23, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28009526/pubertal-progression-and-reproductive-hormones-in-healthy-girls-with-transient-thelarche
#2
Marie Lindhardt Johansen, Casper P Hagen, Mikkel G Mieritz, Ole D Wolthers, Carsten Heuck, Jørgen Holm Petersen, Anders Juul
CONTEXT: Detailed evaluation of pubertal progression in girls from longitudinal studies is sparse and the phenomenon of transient thelarche (TT), defined as the appearance, regression and subsequent reappearance of breast buds, in healthy girls remains undescribed. OBJECTIVE: To describe TT in terms of pubertal progression, growth, genotypes and reproductive hormones and to apply new puberty nomograms for breast stages, pubic hair and menarche. DESIGN: A prospective, longitudinal population-based study...
December 23, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28005440/effect-of-a-single-dose-vitamin-d3-on-postprandial-arterial-stiffness-and-inflammation-in-vitamin-d-deficient-women
#3
Marijke A de Vries, Noëlle van der Meulen, Gert-Jan M van de Geijn, Boudewijn Klop, Ellen M van der Zwan, Lenneke Prinzen, Erwin Birnie, Elsbeth M Westerman, Wouter W de Herder, Manuel Castro Cabezas
CONTEXT: Cholecalciferol (vitamin D3) may improve vascular function and reduce inflammation, potentially providing an explanation for the proposed cardiovascular protection by vitamin D . OBJECTIVE: We investigated whether cholecalciferol supplementation reduces postprandial arterial dysfunction and inflammation. DESIGN: This was a randomized 1:1, double blind trial. SETTING: The study was conducted in the Diabetes and Vascular Center of the Franciscus Gasthuis, Rotterdam, The Netherlands...
December 22, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28001468/long-term-quality-of-life-in-adult-survivors-of-pediatric-differentiated-thyroid-carcinoma
#4
Marloes Nies, Mariëlle S Klein Hesselink, Gea A Huizinga, Esther Sulkers, Adrienne H Brouwers, Johannes G M Burgerhof, Eveline W C M van Dam, Bas Havekes, Marry M van den Heuvel-Eibrink, Eleonora P M Corssmit, Leontien C M Kremer, Romana T Netea-Maier, Heleen J H van der Pal, Robin P Peeters, John T M Plukker, Cécile M Ronckers, Hanneke M van Santen, Wim J E Tissing, Thera P Links, Gianni Bocca
INTRODUCTION: Little is known about long-term quality of life (QoL) of survivors of pediatric differentiated thyroid carcinoma (DTC). Therefore, this study aimed to evaluate generic health-related QoL (HRQoL), fatigue, anxiety, and depression in adult survivors of pediatric DTC compared with matched controls, and to evaluate thyroid cancer-specific HRQoL in survivors only. MATERIALS AND METHODS: Adult survivors of pediatric DTC, diagnosed between 1970-2013 at age <18 years were included...
December 21, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28001459/long-term-effect-of-adrenalectomy-on-cardiovascular-remodeling-in-patients-with-pheochromocytoma
#5
Bohumil Majtan, Tomáš Zelinka, Ján Rosa, Ondřej Petrák, Zuzana Krátká, Branislav Štrauch, Vladimír Tuka, Alice Vránková, David Michalský, Květoslav Novák, Dan Wichterle, Jiří Widimský, Robert Holaj
CONTEXT: Catecholamines may contribute to the accumulation of collagen fibers and extracellular matrix in the arterial and myocardial wall due to various mechanisms. Reversibility of this process has not been studied on both structures simultaneously. OBJECTIVE: This study aimed to clarify the long-term effect of catecholamines' excess normalization on carotid and myocardial wall changes in patients with pheochromocytoma or functional paraganglioma (PHEO) after tumor removal...
December 21, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28001454/metabolic-health-and-long-term-safety-of-growth-hormone-treatment-in-silver-russell-syndrome
#6
C C J Smeets, J S Renes, M van der Steen, A C S Hokken-Koelega
CONTEXT: Children with Silver-Russell syndrome (SRS) are born small for gestational age (SGA) and remain short. Growth hormone (GH)-treatment improves height in short SGA children, including those with SRS. Data on metabolic health and long-term safety of GH-treatment in SRS are lacking. OBJECTIVE: To investigate metabolic health in SRS patients during and until two years after discontinuation of GH-treatment. DESIGN: Metabolic health was assessed longitudinally at GH-start, GH-stop, and six months and two years thereafter...
December 21, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28001453/insulin-resistance-is-associated-with-smaller-cortical-bone-size-in-non-diabetic-men-at-the-age-of-peak-bone-mass
#7
Charlotte Verroken, Hans-Georg Zmierczak, Stefan Goemaere, Jean-Marc Kaufman, Bruno Lapauw
CONTEXT: In type 2 diabetes mellitus, fracture risk is increased despite preserved areal bone mineral density. Although this apparent paradox may in part be explained by insulin resistance affecting bone structure and/or material properties, few studies have investigated the association between insulin resistance and bone geometry. OBJECTIVE: We aimed to explore this association in a cohort of non-diabetic men at the age of peak bone mass. DESIGN, SETTING AND PARTICIPANTS: 996 non-diabetic men aged 25-45 years were recruited in a cross-sectional, population-based sibling-pair study at a university research center...
December 21, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27997272/progesterone-receptors-and-proliferation-of-the-endometrium-in-obese-women-with-polycystic-ovary-syndrome-a-lifestyle-intervention-study
#8
M Paulson, L Sahlin, A L Hirschberg
CONTEXT: Polycystic ovary syndrome (PCOS) is associated with increased risk of endometrial cancer. This is usually explained by chronic anovulation and deficient progesterone activity. However, the role of progesterone receptors (PRs) in endometrial proliferation is unclear. OBJECTIVE: To evaluate PRs in relation to endometrial proliferation in women with PCOS. DESIGN: Cross-sectional study and lifestyle intervention. SETTINGS: Clinical and laboratory research unit at a university hospital...
December 20, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27997268/impaired-apob-lipoprotein-and-triglyceride-metabolism-in-obese-adolescents-with-polycystic-ovary-syndrome
#9
D F Vine, Y Wang, M M Jetha, Gdc Ball, S D Proctor
CONTEXT: Adolescents with Polycystic Ovary Syndrome (PCOS) have atherogenic dyslipidemia and increased cardiovascular disease (CVD) risk, and this is exacerbated in obesity. OBJECTIVE: To determine and compare fasting and non-fasting lipid and ApoB-lipoprotein metabolism in three groups of adolescent girls: i) healthy-weight controls, ii) obese without PCOS (obese-control) and iii) obese with PCOS (obese-PCOS). DESIGN, SETTING AND PARTICIPANTS: Participants aged 12-17 years were recruited for this cross-sectional study from a pediatric weight management clinic and the local community in Alberta, Canada...
December 20, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27992261/effects-of-testosterone-replacement-on-electrocardiographic-parameters-in-men-findings-from-two-randomized-trials
#10
Thiago Gagliano-Jucá, Tevhide Betül İçli, Karol M Pencina, Zhuoying Li, John Tapper, Grace Huang, Thomas G Travison, Panayiotis Tsitouras, S Mitchell Harman, Thomas W Storer, Shalender Bhasin, Shehzad Basaria
CONTEXT: Endogenous testosterone levels have been negatively associated with QTc interval in small case series; the effects of testosterone therapy on electrocardiographic parameters have not been evaluated in randomized trials. OBJECTIVE: To evaluate the effects of testosterone replacement on corrected QT interval (QTcF) in two randomized controlled trials. PARTICIPANTS: Men with pre- and post-randomization electrocardiograms (ECGs) from the Testosterone and Pain (TAP) and the Testosterone Effects on Atherosclerosis in Aging Men (TEAAM) Trials...
December 19, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27992249/the-role-of-epithelial-to-mesenchymal-transition-in-human-amniotic-membrane-rupture
#11
Carla Janzen, Suvajit Sen, Margarida Y Y Lei, Marina Gagliardi de Assumpcao, John Challis, Gautam Chaudhuri
CONTEXT: Biochemical weakening of the amnion is a major factor preceding preterm premature rupture of membranes (PPROM), leading to preterm birth. Activation of matrix metalloproteinases (MMPs) is known to play a key role in collagen degradation of the amnion, yet epithelial to mesenchymal transition (EMT) that is also induced by MMP activation, has not been investigated as a mechanism for amnion weakening. OBJECTIVE: To measure amniotic EMT associated with vaginal delivery (VD) as compared to non-labored cesarean sections (CS), and assess changes in amniotic mechanical strength with pharmacologic inhibitors and inducers of EMT, thus testing the hypothesis that EMT is a key biochemical event that promotes amniotic rupture...
December 19, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27977320/selection-of-high-quality-spermatozoa-may-be-promoted-by-activated-vitamin-d-in-the-woman
#12
Lasse Bøllehuus Hansen, Anders Rehfeld, Rosanna de Neergaard, John Erik Nielsen, Lea Hedegaard Iversen, Ida Marie Boisen, Li Juel Mortensen, Beate Lanske, Kristian Almstrup, Elisabeth Carlsen, Anders Hayden Berg, Niels Jørgensen, Anders Nyboe Andersen, Anders Juul, Martin Blomberg Jensen
CONTEXT: The vitamin D receptor (VDR) and enzymes involved in activation (CYP2R1, CYP27B1) and inactivation (CYP24A1) of vitamin D are expressed in ovary, testes, and spermatozoa. OBJECTIVE: Determine responsiveness to 1,25-dihydroxyvitamin D (1,25(OH)2D3) in spermatozoa from normal and infertile men, identify site of exposure and how 1,25(OH)2D3 influences sperm function. DESIGN: Spermatozoa expressing VDR, CYP2R1, CYP27B1, and CYP24A1 were analyzed in normal and infertile men...
December 15, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27967600/dna-methylation-is-an-independent-prognostic-marker-of-survival-in-adrenocortical-cancer
#13
Anne Jouinot, Guillaume Assie, Rossella Libe, Martin Fassnacht, Thomas Papathomas, Olivia Barreau, Bruno DE LA Villeon, Simon Faillot, Nadim Hamzaoui, Mario Neou, Karine Perlemoine, Fernande Rene-Corail, Stéphanie Rodriguez, Mathilde Sibony, Frédérique Tissier, Bertrand Dousset, Silviu Sbiera, Cristina Ronchi, Matthias Kroiss, Esther Korpershoek, Ronald DE Krijger, Jens Waldmann, Detlef K Bartsch, Marcus Quinkler, Magalie Haissaguerre, Antoine Tabarin, Olivier Chabre, Nathalie Sturm, Michaela Luconi, Franco Mantero, Massimo Mannelli, Regis Cohen, Véronique Kerlan, Philippe Touraine, Gaelle Barrande, Lionel Groussin, Xavier Bertagna, Eric Baudin, Laurence Amar, Felix Beuschlein, Eric Clauser, Joel Coste, Jérôme Bertherat
CONTEXT: Adrenocortical cancer (ACC) is an aggressive tumor with heterogeneous outcome. Prognostic stratification is difficult even based on tumor stage and Ki67 index. Recently integrated genomics studies have demonstrated that CpG islands hypermethylation is correlated with poor survival. OBJECTIVE: To confirm the prognostic value of CpG islands methylation on an independent cohort with a single commonly available methylation assay. DESIGN: CpG islands methylation was measured by methylation-specific-multiplex-ligation-dependent-probe-amplification (MS-MLPA) using the ME002 kit (MRC-Holland)...
December 14, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27967317/the-longitudinal-relationship-between-cortisol-responses-to-mental-stress-and-leukocyte-telomere-attrition
#14
Andrew Steptoe, Mark Hamer, Jue Lin, Elizabeth H Blackburn, Jorge D Erusalimsky
CONTEXT: Chronic psychological stress has been associated with shorter telomeres in some studies, but the underlying mechanisms are poorly understood. One possibility is that the neuroendocrine responses associated with stress exposure are involved. OBJECTIVE: To testing the hypothesis that greater cortisol responsivity to acute stressors predicts more rapid telomere attrition. DESIGN: We measured salivary cortisol responses to two challenging behavioral tasks...
December 14, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27967316/adipogenic-impairment-of-adipose-tissue-derived-mesenchymal-stem-cells-in-subjects-with-metabolic-syndrome-possible-protective-role-of-fgf2
#15
Wilfredo Oliva-Olivera, Leticia Coín-Aragüez, Said Lhamyani, Mercedes Clemente-Postigo, Juan Alcaide Torres, Maria Rosa Bernal-López, Rajaa El Bekay, Francisco José Tinahones
CONTEXT: The decreased expansion capacity of adipose tissue plays a crucial role in the onset of disorders associated with metabolic syndrome. Objetive: The aim of this study was to examine the state of adipose tissue-derived mesenchymal stem cells (ASCs) from obese subjects with different metabolic profiles. DESIGN: This was a 2-year study to enroll subjects who underwent bariatric surgery or cholecystectomy. SETTING: University Hospital Patients and Intervention: Patients who underwent either bariatric surgery (20 morbidly obese) or cholecystectomy (40 subjects) participated in the study...
December 14, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27967308/a-biallelic-mutation-in-the-homologous-recombination-repair-gene-spidr-is-associated-with-human-gonadal-dysgenesis
#16
Pola Smirin-Yosef, Nehama Zuckerman-Levin, Shay Tzur, Yaron Granot, Lior Cohen, Juliane Sachsenweger, Guntram Borck, Irina Lagovsky, Mali Salmon-Divon, Lisa Wiesmüller, Lina Basel-Vanagaite
CONTEXT: Primary ovarian insufficiency (POI) is caused by ovarian follicle depletion or follicle dysfunction, characterized by amenorrhea with elevated gonadotropin levels. The disorder presents as absence of normal progression of puberty. OBJECTIVE: To elucidate the cause of ovarian dysfunction in a family with POI. DESIGN: We performed whole exome sequencing in two affected individuals. To evaluate whether DNA double-stranded break (DSB) repair activities are altered in biallelic mutation carriers we applied an EGFP-based assay for the detection of specific DSB repair pathways in blood-derived cells...
December 14, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27967304/histopathological-classification-of-cross-sectional-image-negative-hyperaldosteronism
#17
Yuto Yamazaki, Yasuhiro Nakamura, Kei Omata, Kazue Ise, Yuta Tezuka, Yoshikiyo Ono, Ryo Morimoto, Yukinaga Nozawa, Celso E Gomez-Sanchez, Scott A Tomlins, William E Rainey, Sadayoshi Ito, Fumitoshi Satoh, Hironobu Sasano
CONTEXT: Approximately half of primary aldosteronism (PA) have clinically evident disease according to clinical (hypertension) and/or laboratory (aldosterone and renin levels) findings but do not have nodules detectable in routine cross-sectional imaging. However, the detailed histopathologic, steroidogenic and pathobiological features of cross-sectional image negative PA have not been well characterized. OBJECTIVE: Examine histopathology, steroidogenic enzyme expression and somatic mutation status of aldosterone-driver genes in adrenals from cross-sectional image negative hyperaldosteronism...
December 14, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27967300/clinical-features-and-management-of-non-hiv-related-lipodystrophy-in-children-a-systematic-review
#18
Nidhi Gupta, Noor Asi, Wigdan Farah, Jehad Almasri, Patricia Moreno Barrionuevo, Mouaz Alsawas, Zhen Wang, Morey W Haymond, Rebecca J Brown, M Hassan Murad
CONTEXT: Lipodystrophy syndromes are characterized by generalized or partial absence of adipose tissue, usually associated with insulin resistance-related conditions. OBJECTIVE: We conducted a systematic review to synthesize existing data on clinical and metabolic features of lipodystrophy (age at onset < 18 years). DATA SOURCE: Sources included Medline, Embase, Cochrane Library, Scopus and Non-Indexed Citations from inception through January 2016...
December 14, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27967299/thiazide-treatment-in-primary-hyperparathyroidism-a-new-indication-for-an-old-medication
#19
Gloria Tsvetov, Dania Hirsch, Ilan Shimon, Carlos Benbassat, Hiba Masri-Iraqi, Alexander Gorshtein, Dana Herzberg, Tzippy Shochat, Ilana Shraga-Slutzky, Talia Diker-Cohen
CONTEXT: There is no available targeted therapy for control of hypercalciuria in nonoperable patients with primary hyperparathyroidism (PHPT). Thiazide diuretics are used for idiopathic hypercalciuria but avoided in PHPT to prevent exacerbating hypercalcemia. Nevertheless, several reports suggested that thiazides may be safe in patients with PHPT. OBJECTIVE: To test the safety and efficacy of thiazides in PHPT. DESIGN: Retrospective analysis of medical records...
December 14, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27967296/new-jag1-mutation-causing-alagille-syndrome-presenting-with-severe-hypercholesterolemia-case-report-with-emphasis-on-genetics-and-lipid-abnormalities
#20
Zeina C Hannoush, Herminia Puerta, Mislen S Bauer, Ronald B Goldberg
CONTEXT: Alagille syndrome is a rare autosomal dominant genetic disorder caused by defects in the Notch signaling pathway that involves multiple organ systems. Bile duct paucity is the main characteristic feature of the disease, which often leads to cholestatic hypercholesterolemia. CASE DESCRIPTION: We report the case of a male infant who at one year of age had developed failure to thrive, jaundice, intermittent pruritus and multiple diffuse symmetrical skin xanthomas...
December 14, 2016: Journal of Clinical Endocrinology and Metabolism
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