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Journal of Clinical Endocrinology and Metabolism

Marta Guasch-Ferré, Miguel Ruiz-Canela, Jun Li, Yan Zheng, Mònica Bulló, Dong D Wang, Estefanía Toledo, Clary Clish, Dolores Corella, Ramon Estruch, Emilio Ros, Montserrat Fitó, Fernando Arós, Miquel Fiol, José Lapetra, Lluís Serra-Majem, Liming Liang, Christopher Papandreou, Courtney Dennis, Miguel A Martínez-González, Frank B Hu, Jordi Salas-Salvadó
Context: The potential associations between acylcarnitine profiles and incidence of T2D, and whether acylcarnitines can be used to improve diabetes prediction remains unclear. Objective: To evaluate the associations between baseline and 1-year changes in acylcarnitines, and their diabetes predictive ability beyond traditional risk factors. Design, setting and participants: We designed a case-cohort study within the PREDIMED Study including all incident cases of T2D(n=251) and 694 randomly selected participants at baseline(follow-up:3...
November 13, 2018: Journal of Clinical Endocrinology and Metabolism
Chantal Zevenbergen, Stefan Groeneweg, Sigrid M A Swagemakers, Arthur de Jong, Evita Medici-Van den Herik, Madzy Rispens, Wim Klootwijk, Marco Medici, Yolanda B de Rijke, Marcel E Meima, P Reed Larsen, Laurent Chavatte, Deon Venter, Robin P Peeters, Peter J Van der Spek, W Edward Visser
Context: Thyroid hormone (TH) is important for normal brain development. The type 2 deiodinase (D2) controls TH action in the brain by activating T4 to T3. The enzymatic activity of D2 depends on the incorporation of selenocysteine (Sec) for which the SECIS element located in the 3`UTR is indispensable. We hypothesized that mutations in the SECIS element could impact on D2 function, resulting in a neurocognitive phenotype. Objective: To identify mutations in the SECIS element of DIO2 in patients with intellectual disability (ID) and to test their functional consequences...
November 13, 2018: Journal of Clinical Endocrinology and Metabolism
Berit A M Larsson, Daniel Sundh, Dan Mellström, Kristian F Axelsson, Anna G Nilsson, Mattias Lorentzon
Context: Treatment with statins has been associated with increased bone mineral density (BMD), but if this association depends on differences in cortical or trabecular volumetric bone microstructure is unknown. Objective: The aim of this study was to investigate if treatment with statins is associated with bone microstructure and geometry in older women. Design setting and participants: Older women were included in a population-based study of 3,028 women (mean age ± SD: 77...
November 13, 2018: Journal of Clinical Endocrinology and Metabolism
Rachel L Boal, Yi Shiau Ng, Sarah Pickett, Andrew M Schaefer, Catherine Feeney, Alex Bright, Robert W Taylor, Doug M Turnbull, Grainne S Gorman, Tim Cheetham, Robert McFarland
Context: Abnormal growth and short stature are observed in patients with mitochondrial disease but it is unclear whether there is a relationship between final adult height, and disease severity. Objective: To determine whether patients with genetically confirmed mitochondrial disease are shorter than their peers and whether stature is related to disease severity. Design: Analysis of final adult height in relation to disease severity determined by the Newcastle Mitochondrial Disease Adult Scale (NMDAS)...
November 13, 2018: Journal of Clinical Endocrinology and Metabolism
A García-Martínez, J Sottile, L Sánchez-Tejada, C Fajardo, R Cámara, C Lamas, V M Barberá, A Picó
Context: Epigenetic alterations may play a role in the development and behaviour of Pituitary Neuroendocrine Tumours (PitNETs). Objective: To evaluate the effect of methylation of Tumour Suppressor Genes (TSGs) in their gene expression and in the behaviour of PitNETs. Material and Methods: We use MS-MLPA and q-RT-PCR techniques to analyse the DNA-promoter hypermethylation and the gene expression of 35 TSGs in 105 PitNETs. We define functionality, size and invasiveness of tumours according to their clinical manifestations, Hardy's classification and MRI invasion of the cavernous sinus, respectively...
November 12, 2018: Journal of Clinical Endocrinology and Metabolism
A M H Horstman, I W K Kouw, J W van Dijk, H M Hamer, B B L Groen, J van Kranenburg, S H M Gorissen, L J C van Loon
Rationale: Muscle mass maintenance is largely regulated by the postprandial rise in muscle protein synthesis rates. It remains unclear whether postprandial protein handling differs between women and men. Methods: Healthy men (43±3 y; BMI: 23.4±0.4 kg/m2; n=12) and women (46±2 y; BMI: 21.3±0.5 kg/m2; n=12) received primed continuous infusions of L-[ring-2H5]-phenylalanine and L-[ring-3,5-2H2]-tyrosine and ingested 25 g intrinsically L-[1-13C]-phenylalanine-labeled whey protein...
November 12, 2018: Journal of Clinical Endocrinology and Metabolism
Ju-Sheng Zheng, Fumiaki Imamura, Stephen J Sharp, Yvonne T van der Schouw, Ivonne Sluijs, Thomas E Gundersen, Eva Ardanaz, Heiner Boeing, Catalina Bonet, Jesus Humberto Gómez, Courtney Dow, Guy Fagherazzi, Paul W Franks, Mazda Jenab, Tilman Kühn, Rudolf Kaaks, Timothy J Key, Kay-Tee Khaw, Cristina Lasheras, Olatz Mokoroa, Francesca Romana Mancini, Peter M Nilsson, Kim Overvad, Salvatore Panico, Domenico Palli, Olov Rolandsson, Sabina Sieri, Elena Salamanca-Fernández, Carlotta Sacerdote, Annemieke Mw Spijkerman, Magdalena Stepien, Anne Tjonneland, Rosario Tumino, Adam S Butterworth, Elio Riboli, John Danesh, Claudia Langenberg, Nita G Forouhi, Nicholas J Wareham
Background: Existing evidence for the prospective association of vitamin D status with type 2 diabetes (T2D) is focused almost exclusively on circulating total 25-hydroxyvitamin D [25(OH)D] without distinction between its subtypes: non-epimeric and epimeric 25(OH)D3 stereoisomers; and 25(OH)D2, the minor component of 25(OH)D. We aimed to investigate the prospective associations of circulating levels of the sum and each of these three metabolites with incident T2D. Methods: This analysis in the EPIC-InterAct case-cohort study for T2D included 9671 incident T2D cases and 13562 subcohort members...
November 9, 2018: Journal of Clinical Endocrinology and Metabolism
Bernadette Biondi
No abstract text is available yet for this article.
November 9, 2018: Journal of Clinical Endocrinology and Metabolism
Alessandro Ciresi, Giuseppe Pizzolanti, Valentina Guarnotta, Carla Giordano
PURPOSE: To evaluate circulating irisin levels in children with growth hormone deficiency (GHD) and any relation with clinical and metabolic parameters. PATIENTS: Fifty-four prepubertal children (mean age 7.4 ± 0.8 years) with idiopathic GHD treated with GH for at least 12 months and 31 healthy short children as controls. METHODS: Body height, body mass index (BMI), waist circumference (WC), insulin-like growth factor (IGF)-I, HbA1c, lipid profile, fasting and after-OGTT glucose and insulin, insulin sensitivity indices and irisin levels were evaluated at baseline and after 12 months of growth hormone replacement (GHR)...
November 9, 2018: Journal of Clinical Endocrinology and Metabolism
Deqiang Zheng, Jingtao Dou, Guangxu Liu, Yuesong Pan, Yuxiang Yan, Fen Liu, Herbert Y Gaisano, Juming Lu, Yan He
Context: Elevated blood triglyceride levels are known to increase the risk of diabetes and prediabetes. However, it is still unclear whether elevated triglyceride levels are associated with inadequate glycemic control in type 2 diabetic patients. Objective: To investigate the association between elevated triglyceride levels and inadequate glycemic control among insulin-treated patients with type 2 diabetes. Design, Setting, and Patients: We recruited 20,108 type 2 diabetic patients who were treated with a sufficient dose of insulin...
November 9, 2018: Journal of Clinical Endocrinology and Metabolism
Christian L Roth, Susan J Melhorn, Clinton T Elfers, Kelley Scholz, Mary Rosalynn B De Leon, Maya Rowland, Sue Kearns, Elizabeth Aylward, Thomas J Grabowski, Brian E Saelens, Ellen A Schur
Context: Behavioral studies suggest that responses to food consumption are altered in children with obesity. Objective: To test central nervous system and peripheral hormone response by functional magnetic resonance imaging (fMRI) and satiety-regulating hormone levels before and after a meal. Design and Setting: Cross-sectional study comparing children with obesity (OB) and children of healthy weight (HW) recruited from across the Puget Sound region of Washington...
November 9, 2018: Journal of Clinical Endocrinology and Metabolism
Raffaella Labbadia, Carla Bizzarri, Mafalda Mucciolo, Giacomo Di Zazzo, Isabella Guzzo, Marco Cappa, Francesco Emma, Luca Dello Strologo
Context: Type 1A Pseudohypoparathyroidism (PHP-1A) is characterized by target organ resistance to parathyroid hormone (PTH). Patients can show various dysmorphic features, but renal failure is not classically described. Case Description: A female patient came to our attention at the age of seven years with characteristic signs of PTH resistance, namely hypocalcemia, hyperphosphatemia and high serum PTH levels. She also presented hypothyroidism, early-onset obesity, short metacarpal bones and multiple subcutaneous ossifications leading to a clinical diagnosis of pseudohypoparathyroidism In addition to her genetic condition, she had bilateral renal hypodysplasia slowly progressing to end-stage kidney disease...
November 9, 2018: Journal of Clinical Endocrinology and Metabolism
Nivedita Patni, Xilong Li, Beverley Adams-Huet, Chandna Vasandani, Rita A Gomez-Diaz, Abhimanyu Garg
Context: Familial partial lipodystrophy, Dunnigan variety (FPLD2) is a rare autosomal dominant disorder due to heterozygous missense LMNA mutations. FPLD2 subjects gradually lose fat from the upper and lower extremities but gain fat in the face and neck around puberty. However, the precise onset of body fat changes and metabolic complications during childhood remains unknown. Objective: To compare metabolic parameters and regional body fat in children with FPLD2 with the sex- and age-matched controls from the National Health and Nutrition Examination Survey (NHANES) 2005-2010...
November 9, 2018: Journal of Clinical Endocrinology and Metabolism
Olah Hakim, Riccardo C Bonadonna, Cynthia Mohandas, Zoya Billoo, Alexander Sunderland, Linda Boselli, K George M M Alberti, Janet L Peacock, A Margot Umpleby, Geoff Charles-Edwards, Stephanie A Amiel, Louise M Goff
Context: Intrapancreatic lipid (IPL) has been linked with beta-cell dysfunction. Black populations suffer disproportionately from type 2 diabetes (T2D) and show distinctions in beta-cell function compared to Whites. Objective: We aimed to quantify IPL in White European (WE) and Black West African (BWA) men with early T2D, and to investigate relationships between IPL and beta-cell insulin secretory function (ISF). Design, Setting and Participants: We performed a cross-sectional assessment of 18 WE and 19 BWA middle-aged men with early T2D as part of the South London Diabetes and Ethnicity Phenotyping (Soul-Deep) study...
November 7, 2018: Journal of Clinical Endocrinology and Metabolism
(no author information available yet)
No abstract text is available yet for this article.
November 7, 2018: Journal of Clinical Endocrinology and Metabolism
(no author information available yet)
No abstract text is available yet for this article.
November 7, 2018: Journal of Clinical Endocrinology and Metabolism
Jane E Yardley, Jordan L Rees, Deanna R Funk, Saeed Reza Toghi-Eshghi, Normand G Boulé, Peter A Senior
Context: Islet transplantation is effective in preventing hypoglycemia in individuals with type 1 diabetes (T1D). However, it is currently unknown whether transplanted islets regulate plasma glucose concentrations appropriately during and after exercise in human islet transplant recipients (ITx). Objective: To determine the effect of exercise on plasma glucose, insulin, and glucagon concentrations in ITx compared to individuals without diabetes (CON). Intervention: Participants completed two conditions in random order, 1) 45 minutes of aerobic exercise (60% VO2peak), and 2) 45 minutes of seated rest...
November 6, 2018: Journal of Clinical Endocrinology and Metabolism
Irakoze Laurent, Manirakiza Astère, Fengfan Zheng, Xiangjun Chen, Jun Yang, Qingfeng Cheng, Qifu Li
Context: Adrenal venous sampling (AVS) with or without adrenocorticotropic hormone (ACTH) stimulation is the test of choice to identify patients with a surgically curable subtype of primary aldosteronism (PA). Whether AVS with ACTH stimulation is more effective than AVS without ACTH stimulation remains controversial. Objective: To compare the effectiveness of AVS with ACTH stimulation and AVS without ACTH stimulation in patients with PA. Methods: The Cochrane Library, PubMed, Embase, and Web of Science databases were searched to identify relevant articles...
November 6, 2018: Journal of Clinical Endocrinology and Metabolism
Andrea Di Nisio, Iva Sabovic, Umberto Valente, Simone Tescari, Maria Santa Rocca, Diego Guidolin, Stefano Dall'Acqua, Laura Acquasaliente, Nicola Pozzi, Mario Plebani, Andrea Garolla, Carlo Foresta
Background: Considerable attention has been paid to perfluoroalkyl compounds (PFCs) because of their worldwide presence in humans, wildlife, and environment. A wide variety of toxicological effects is well supported in animals, including testicular toxicity and male infertility. For these reasons, the understanding of epidemiological associations and of the molecular mechanisms involved in the endocrine-disrupting properties of PFCs on human reproductive health is a major concern. Objective: To investigate the relationship between PFCs exposure and male reproductive health...
November 6, 2018: Journal of Clinical Endocrinology and Metabolism
Alanna Dunn, Anna Lam, Luis Hidalgo, Am James Shapiro, Peter A Senior
Context: Clinical islet transplantation (CIT) is an innovative strategy to treat highly selected individuals with type 1 diabetes mellitus (T1DM). Lymphodepletion with alemtuzumab or thymoglobulin is often used for induction therapy in CIT. Alemtuzumab was recently licensed as a treatment for relapsing remitting multiple sclerosis (RRMS). In RRMS, autoimmune thyroid disease (AITD) has developed in up to 40% of individuals treated with alemtuzumab. The appearance of AITD after CIT is not well described...
November 5, 2018: Journal of Clinical Endocrinology and Metabolism
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