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Journal of Clinical Endocrinology and Metabolism

Elise M Philips, Linda G Kahn, Vincent W V Jaddoe, Yongzhao Shao, Alexandros G Asimakopoulos, Kurunthachalam Kannan, Eric A P Steegers, Leonardo Trasande
Background: Increasing evidence suggests that exposure to synthetic chemicals such as bisphenols and phthalates can influence fecundability. The current study describes associations of first trimester urinary concentrations of bisphenol A (BPA), BPA analogues and phthalate metabolites with time to pregnancy (TTP). Methods: Among 877 participants in the population-based Generation R pregnancy cohort, we measured first trimester urinary concentrations of bisphenols and phthalates (median gestational age 12...
July 16, 2018: Journal of Clinical Endocrinology and Metabolism
Amit Pandya, Elaine M Caoili, Farah Jawad-Makki, Ashish P Wasnik, Prasad R Shankar, Ron Bude, Megan R Haymart, Matthew S Davenport
Background: The 2015 American Thyroid Association (ATA) guidelines have been proposed to aid in the management of thyroid nodules by determining whether FNA is indicated. Objective: To determine if the ATA guidelines contribute to the overdiagnosis of thyroid cancer. Patients and methods: This was a retrospective cohort study of ultrasound imaged thyroid nodules (n=1,947) consecutively aspirated at a tertiary care center from 10/1/2009 to 2/22/2016...
July 3, 2018: Journal of Clinical Endocrinology and Metabolism
Yuanjun Lyu, Yingying Luo, Changping Li, Xiaohui Guo, Juming Lu, Honghua Wu, Xiaoxu Huo, Weijun Gu, Guoqing Yang, Linong Ji, Xilin Yang
Background: There are large regional variations in the prevalence and mortality of cardiovascular disease in general populations in China. It remains uncertain whether the prevalence in type 2 diabetes mellitus (T2DM) varied by region in China. Methods: We analyzed data of 219,522 Chinese patients with T2DM retrieved from the China National HbA1c Surveillance System in 2012. We used the Chinese population distribution in 2010 to standardize prevalence of coronary heart disease (CHD), stroke and composite of both in 30 provinces and 7 geological regions...
July 3, 2018: Journal of Clinical Endocrinology and Metabolism
David Neil, Richard V Clark, Mindy Magee, Julia Billiard, Ann Chan, Zhengyu Xue, Alan Russell
Objective: This was a phase 1b study intended to explore across a dose range the pharmacokinetic (PK) - pharmacodynamic (PD) relationship and further safety and tolerability data for GSK2881078. This study also evaluated effects of CYP3A4 inhibition on pharmacokinetics (PK) of GSK2881078. Methods: This was a randomized, placebo controlled, parallel group, repeat dose, dose-escalation study in healthy older males and post-menopausal females. A total of 3 cohorts of males and 3 cohorts of females were studied...
July 2, 2018: Journal of Clinical Endocrinology and Metabolism
Seung Eun Lee, Kyungdo Han, Ji Yeon Baek, Kyung Soo Ko, Ki-Up Lee, Eun Hee Koh
Context: Studies have shown an association between diabetes and Parkinson's disease (PD). The retina is a part of the central nervous system (CNS); it was proposed that diabetic retinopathy (DR) and PD share common pathophysiology of dopamine deficiency. However, no epidemiologic studies have investigated the relationship between these two diseases. Objective: We assessed the association between DR and incident PD using a population-based database. Design/Setting/Participants: Using the Korean National Health Insurance Service database, 14,912,368 participants who underwent regular health check-up from 2005 to 2008 were included...
July 2, 2018: Journal of Clinical Endocrinology and Metabolism
Christine E Cherella, Henry A Feldman, Monica Hollowell, Danielle M Richman, Edmund S Cibas, Jessica R Smith, Trevor Angell, Zhihong Wang, Erik K Alexander, Ari J Wassner
Context: Most pediatric thyroid nodules are cytologically benign, but few data exist to guide management of these nodules. Objective: To describe the natural history and outcomes of cytologically benign pediatric thyroid nodules. Design: Cohort study. Setting: Multidisciplinary thyroid clinic at an academic pediatric and adult center. Patients: Consecutive pediatric patients (≤18 years) with cytologyically benign thyroid nodules evaluated between 1998-2016...
July 2, 2018: Journal of Clinical Endocrinology and Metabolism
Arash Derakhshan, Huan Shu, Maarten A C Broeren, Ralph A de Poortere, Sverre Wikström, Robin P Peeters, Barbara Demeneix, Carl-Gustaf Bornehag, Tim I M Korevaar
Context: Establishing reference ranges as well as identifying and quantifying the determinants of thyroid function during pregnancy is important for proper clinical interpretation and optimizing research efforts. However, such data are sparse, specifically for (F)T3 measurements and most studies do not take into account thyroid antibodies or hCG. Objective: To determine reference ranges and to identify/quantify determinants of TSH, FT4, FT3, TT4 and TT3. Design, Setting and Participants: This study included 2,314 participants of the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy study, a population-based prospective pregnancy cohort of mother-child pairs...
July 2, 2018: Journal of Clinical Endocrinology and Metabolism
Freek J H Sorgdrager, Jorien Werumeus Buning, Elske H Bos, André P Van Beek, Ido P Kema
Context: Hydrocortisone (HC) treatment influences health-related quality of life (HRQOL) in secondary adrenal insufficiency (AI). Glucocorticoids regulate tryptophan metabolism through the kynurenine pathway which modulates mood and energy homeostasis. Objective: This study investigated whether tryptophan metabolism mediated the effect of HC dose on HRQOL in patients with secondary AI. Design, Setting and Patients: Forty-seven patients with secondary AI participated in this double-blind randomized controlled cross-over trial in the University Medical Center Groningen...
July 2, 2018: Journal of Clinical Endocrinology and Metabolism
Michael H Guo, Joel N Hirschhorn, Andrew Dauber
Context: In the last decade, genome wide association studies (GWAS) have catalyzed our understanding of the genetics of height and have identified hundreds of regions of the genome associated with adult height and other height-related body measurements. Evidence Acquisition: GWAS studies related to height were identified via Pubmed search and a review of the GWAS catalog ( Evidence Synthesis: The GWAS results demonstrate that height is highly polygenic; that is, many thousands of genetic variants distributed across the genome each contribute to an individual's height...
July 2, 2018: Journal of Clinical Endocrinology and Metabolism
Jiayun Shen, James F Griffith, Tracy Y Zhu, Peggy Tang, Emily W Kun, Violet K Lee, Ronald M Yip, Kitty Y Kwok, Shirley K Ying, Carmen T Ho, Sze-Lok Lau, Michelle O Pui, Tena K Li, Eleven Y Lau, Jack J Lee, Ling Qin, Lai-Shan Tam
Context: Measurement of areal bone mineral density (aBMD) by dual-energy x-ray absorptiometry (DXA) was able to predict fracture risk. High-resolution peripheral quantitative computed tomography (HR-pQCT) yields additional information about volumetric BMD (vBMD), microarchitecture, and strength that may increase understanding of fracture susceptibility. Objective: To ascertain whether vBMD, microarchitecture and estimated bone strength derived from HR-pQCT can discriminate vertebral fractures in glucocorticoid-induced osteoporosis (GIOP) patients independent of aBMD...
July 2, 2018: Journal of Clinical Endocrinology and Metabolism
Matthew R Brown, Aleksey V Matveyenko
No abstract text is available yet for this article.
July 2, 2018: Journal of Clinical Endocrinology and Metabolism
Yi Liu, John A Carrino, Alexander S Dash, Tariq Chukir, Huong Do, Richard S Bockman, Alexander P Hughes, Joel M Press, Emily M Stein
Context: Epidural steroid injections (ESI) are a common, effective treatment for lumbar radiculopathy and sciatica. While the negative skeletal effects of oral glucocorticoids are well established, little is known about the impact of ESI on bone quality. DXA is subject to artifact in patients with spine pathology and may have limited utility in this population. Objective: To investigate the relationship between ESI exposure and volumetric bone density (vBMD) at the lumbar spine (LS) using central quantitative CT (cQCT)...
July 2, 2018: Journal of Clinical Endocrinology and Metabolism
Shu-Man Lin, Jen-Hung Wang, Chung-Chao Liang, Huei-Kai Huang
Context: Post-stroke osteoporosis and consequent fracture increase the risk of morbidity and mortality and cause considerable socioeconomic burden. Objective: To evaluate the association between statin use and risks of osteoporosis and fracture in stroke patients. Design: Population-based propensity score-matched cohort study. Setting: National Health Insurance Research Database in Taiwan. Patients: Patients newly diagnosed with a stroke, between 2000 and 2012, were identified...
July 2, 2018: Journal of Clinical Endocrinology and Metabolism
Marlen Vitales-Noyola, Ana Serrano-Somavilla, Rebeca Martínez-Hernández, Miguel Sampedro-Nuñez, Ana M Ramos-Levi, Roberto González-Amaro, Mónica Marazuela
Context: T regulatory type 1 (Tr1) cells are a subpopulation of T lymphocytes (CD4+CD49+LAG-3+IL-10+) that exerts a significant immunosuppressive effect. However, its possible role in autoimmune thyroid disease (AITD) has not been explored so far. Purpose: To analyze the levels and function of Tr1 cells in peripheral blood and thyroid tissue of patients with AITD. Design: Cases and controls, observational study. Setting: Department of Endocrinology, Hospital Universitario de la Princesa, Madrid, Spain...
July 2, 2018: Journal of Clinical Endocrinology and Metabolism
Jad G Sfeir, Nana Esi Kittah, Shrikant U Tamhane, Sina Jasim, Wassim Chemaitilly, Laurie Cohen, M Hassan Murad
Background: Limited guidance exists for selecting a laboratory method for diagnosing growth hormone deficiency (GHD) when it occurs as a late effect of radiotherapy in childhood cancer survivors (CCS). Methods: We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and Database of Systematic Reviews, and Scopus for studies evaluating GHD using IGF-I and/or IGFBP-3 measurements compared to GH dynamic testing. Results: We included 15 studies [IGF-I (8) and IGFBP-3 (7)] enrolling 477 patients...
June 29, 2018: Journal of Clinical Endocrinology and Metabolism
Shrikant Tamhane, Jad G Sfeir, Nana Esi N Kittah, Sina Jasim, Wassim Chemaitilly, Laurie E Cohen, M Hassan Murad
Background: Growth hormone deficiency (GHD) is common among childhood cancer survivors (CCS) with history of tumors, surgery and/or radiotherapy involving the hypothalamus-pituitary (HP) region. We aimed to evaluate the effects of growth hormone therapy (GHT) in CCS on adult height, risk of diabetes mellitus, abnormal lipids, metabolic syndrome, quality of life, secondary tumors and disease recurrence. Methods: We searched multiple databases for randomized and observational studies...
June 29, 2018: Journal of Clinical Endocrinology and Metabolism
Charles A Sklar, Zoltan Antal, Wassim Chemaitilly, Laurie E Cohen, Cecilia Follin, Lillian R Meacham, M Hassan Murad
Objective: To formulate clinical practice guidelines for the endocrine treatment of hypothalamic-pituitary and growth disorders in survivors of childhood cancer. Participants: An Endocrine Society-appointed guideline writing committee of six medical experts and a methodologist. Conclusions: Due to remarkable improvements in childhood cancer treatment and supportive care during the past several decades, 5-year survival rates for childhood cancer currently are >80%...
June 29, 2018: Journal of Clinical Endocrinology and Metabolism
Katrien Clotman, Katleen Janssens, Pol Specenier, Ilse Weets, Christophe E M De Block
Context: Pembrolizumab (Keytruda) is a humanized IgG4 monoclonal antibody used in cancer immunotherapy. It targets the programmed cell death-1 (PD-1) receptor which is important in maintaining self-tolerance. However, immune checkpoint blockade is associated with a risk for immune-related adverse events (irAE) potentially affecting the endocrine organs. Type 1 diabetes mellitus is a rare irAE of PD-1 inhibitors, occurring in 0.2% of cases. Evidence Acquisition: Systematic search of 4 databases (Medline, Embase, Web of Science and Cochrane Library) using the search terms "diabetes" or "ketoacidosis" and "pembrolizumab", "nivolumab", "PD-1 inhibitor" or "immunotherapy...
June 27, 2018: Journal of Clinical Endocrinology and Metabolism
Henriette Ejlsmark-Svensson, Lise Sofie Bislev, Lars Rolighed, Tanja Sikjær, Lars Rejnmark
Context: Some patients with primary hyperparathyroidism (PHPT) develop renal calcifications. Investigation of urinary and non-urinary risk factors are essential. Objective: We aimed to study the prevalence and potential biochemical predictors of renal calcifications. Design: Nested case-control study. Settings: University Hospital. Patients or Other Participants: We identified 792 patients with PHPT from 2005-2015...
June 27, 2018: Journal of Clinical Endocrinology and Metabolism
Janice B Schwartz, Christopher Gallagher, Rolf Jorde, Vivian Berg, Jennifer Walsh, Richard Eastell, Amy L Evans, Simon Bowles, K E Naylor, Kerry S Jones, Inez Schoenmakers, Michael Holick, Eric Orwoll, Carrie Nielson, Martin Kaufman, Glenville Jones, Roger Bouillon, Jennifer Lai, Davide Verotta, Daniel Bikle
Context: The optimal measure of vitamin D(D) status is unknown. Objective: Directly measure circulating free 25(OH)D concentrations and relationships to total 25(OH)D in a clinically diverse sample of humans. Design: Cross-sectional analysis. Setting: Seven academic sites. Patients: 1661 adults: (healthy(n=211), pre-diabetic(n=479), outpatients(n=783), cirrhotic(n=90), pregnant(n=20), nursing home(n=79))...
June 27, 2018: Journal of Clinical Endocrinology and Metabolism
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