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European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies

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https://www.readbyqxmd.com/read/29443444/diabetes-and-intracerebral-hemorrhage-baseline-characteristics-and-mortality
#1
Ron Liebkind, Daniel Gordin, Daniel Strbian, Atte Meretoja, Lena M Thorn, Stephanie Hägg-Holmberg, Carol Forsblom, Turgut Tatlisumak, Per-Henrik Groop, Jukka Putaala
BACKGROUND: Acknowledging the conflicting evidence of diabetes as a predictor of short- and long-term mortality following an intracerebral hemorrhage (ICH), we compared baseline characteristics and 30-day and long-term mortality between patients with and without diabetes after an ICH-paying special attention to differences between type 1 (T1D) and type 2 (T2D) diabetes. METHODS: Patients with a first-ever ICH were followed for a median of 2.3 years. Adjusting for demographics, comorbidities and documented ICH characteristics increasing mortality after ICH, logistic regression analysis assessed factors associated with case-fatality and 1-year survival among the 30-day survivors...
February 14, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29443442/paediatric-adem-followed-by-optic-neuritis-disease-course-treatment-response-and-outcome
#2
Y Y M Wong, Y Hacohen, T Armangue, E Wassmer, H Verhelst, C Hemingway, E D van Pelt, C E Catsman-Berrevoets, R Q Hintzen, K Deiva, M J Lim, K Rostásy, R F Neuteboom
BACKGROUND: Acute disseminated encephalomyelitis, followed by optic neuritis (ADEM-ON) is a rare demyelinating syndrome different than MS and neuromyelitis optica spectrum disorder. We aim to describe the disease course, treatment response and outcome of these children. METHODS: children <18 years were identified from 6 countries of the EU Paediatric Demyelinating Disease Consortium. Patients fulfilled the diagnostic criteria for ADEM, followed by at least one ON...
February 14, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29442416/t1-or-t2-weighted-mri-what-is-the-best-choice-to-evaluate-the-atrophy-of-the-hippocampus
#3
Cyrielle Fischbach-Boulanger, Aikaterini Fitsiori, Vincent Noblet, Seyyid Baloglu, Hélène Oesterle, Silviu Draghici, Nathalie Philippi, Emmanuelle Duron, Olivier Hanon, Jean-Louis Dietemann, Frédéric Blanc, Stéphane Kremer
BACKGROUND: MR imaging is part of the diagnostic criteria for Alzheimer's disease through the evaluation of hippocampal atrophy. The objective of this study is to evaluate which sequence between T1 Weighted Imaging (T1WI) and T2 Weighted Imaging (T2WI) allows the best visual evaluation of hippocampal atrophy. METHODS: Visual qualitative ratings of the hippocampus of 100 MCI and 50 AD patients were made independently by four operators according to the Medial Temporal lobe Atrophy (MTA) score based either on T1WI or T2WI...
February 14, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29442411/a-multiprofessional-approach-to-teach-child-neurology-in-africa-a-powerful-project-for-local-needs-and-the-avoidance-of-brain-drain
#4
Wolfgang Grisold
The article by M. Leone [1] describes an interesting educational project in Mozambique, a joint project of the Besta Neurological Institute, Milan and the neuropaediatric and EEG unit in Maputo. The aim is the training of paediatric neurologists locally with support and supervision of a European department. As such it does not only increase local capacities, but also empowers the region for further local training. This article is protected by copyright. All rights reserved.
February 14, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29437287/novel-mutations-in-dnajb6-cause-lgmd1d-and-distal-myopathy-in-french-families
#5
Per H Jonson, Johanna Palmio, Mridul Johari, Sini Penttilä, Anni Evilä, Isabelle Nelson, Gisèle Bonne, Nicolas Wiart, Vincent Meyer, Anne Boland, Jean-François Deleuze, Cécile Masson, Tanya Stojkovic, Françoise Chapon, Norma B Romero, Guilhem Solé, Xavier Ferrer, Ana Ferreiro, Peter Hackman, Isabelle Richard, Bjarne Udd
BACKGROUND AND PURPOSE: To determine the genetic background of unknown muscular dystrophy in five French families. METHODS: Twelve patients with limb girdle muscular dystrophy or distal myopathy were clinically evaluated. Gene mutations were identified using targeted exon sequencing and mutated DNAJB6 was tested in vitro. RESULTS: Five patients presented with distal lower limb weakness while others had proximal presentation with variable rate of progression starting at the median age of 34...
February 13, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29431886/impact-of-anemia-on-in-hospital-complications-after-ischemic-stroke
#6
Chen-Chen Wei, Shu-Ting Zhang, Ge Tan, Shi-Hong Zhang, Ming Liu
BACKGROUND: In-hospital complications after stroke represent barriers of optimal recovery and are even potentially life-threatening. Anemia is common in stroke patients and is related to poor outcome after stroke. Less is known, however, of the association of anemia with complications. We aimed to investigate the impact of anemia on a series of in-hospital complications after ischemic stroke. METHODS: Consecutive patients with ischemic stroke within 7 days were included...
February 12, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29431884/successes-and-optimism-in-deep-brain-stimulation-for-neurological-disorders-ripe-for-a-surgical-time-out
#7
Alexander I Tröster
In the USA, the Food and Drug Administration (FDA) has approved deep brain stimulation (DBS) devices for the treatment of Parkinson's disease (PD), essential tremor (ET), dystonia, and obsessive compulsive disorder (OCD). DBS has been approved for these same conditions in Europe, but, additionally the European Commission (EC) has granted the Conformité Européenne (CE) Mark for DBS as adjunctive treatment for partial-onset seizures in adults with medically refractory epilepsy. In this issue of EJN Budman and colleagues [1] briefly review the range of neurologic conditions that might constitute promising new indications for DBS...
February 12, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29431878/characteristics-associated-with-outcome-in-first-ever-posterior-fossa-stroke-patients
#8
Kersten Villringer, Malgorzata Florczak-Rzepka, Ulrike Grittner, Peter Brunecker, Hans Tepe, Christian H Nolte, Jochen B Fiebach
BACKGROUND: Factors like infarct volume, infarct location and symptom severity can considerably influence long-term outcome in posterior fossa strokes. Therapy decision can sometimes be complicated by discrepancies between infarct volume and clinical severity. We aimed to evaluate imaging and clinical parameters possibly influencing long-term outcome in first-ever posterior fossa stroke patients. METHODS: Imaging was performed on a 3 T MRI scanner. Sixty-one out of 1795 patients from the observational 1000Plus and LOBI studies (clinicaltrials...
February 12, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29431876/real-life-long-term-effectiveness-of-fingolimod-in-swiss-patients-with-relapsing-remitting-multiple-sclerosis-realite
#9
Chiara Zecca, Serge Roth, Oliver Findling, Guillaume Perriard, Valérie Bachmann, Misha L Pless, Andreas Baumann, Christian P Kamm, Patrice H Lalive, Adam Czaplinski
BACKGROUND AND PURPOSE: In 2011, fingolimod was approved in Switzerland for the treatment of relapsing remitting multiple sclerosis (RRMS). The aim of the present study was to assess the effectiveness and retention of fingolimod in a real life Swiss setting, in which patients can receive fingolimod both as first or second line treatment for RRMS. METHODS: This cross-sectional, observational study with retrospective data collection was performed at 19 sites that comprised both hospitals and office-based physicians across Switzerland...
February 12, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29427462/is-diffusion-mri-the-future-biomarker-to-measure-therapeutic-efficacy-in-multiple-sclerosis
#10
Zsigmond Tamas Kincses, László Vécsei
MRI is the cornerstone of the diagnosis of multiple sclerosis (MS), and in recent years it was advocated for the follow up of the efficacy of the ever-growing number of disease modifying treatments (DMT). While in the clinical practice the most important biomarkers are still the T2 and T1 enhancing lesion burden, clinical studies are already utilising atrophy estimation. These measures cover a vast majority of MS pathology, namely the perivenular inflammation and gliosis in the white matter lesions as well as grey matter pathology...
February 10, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29427459/acute-amnestic-syndrome-in-isolated-bilateral-fornix-stroke
#11
Alessandro Salvalaggio, Annachiara Cagnin, Lucia Nardetto, Renzo Manara, Chiara Briani
BACKGROUND: Acute onset of amnestic syndrome may represent a challenging diagnostic issue. Besides non-vascular etiology, thalamic strokes or infarction involving several temporal lobe structures has been reported. PATIENTS: We describe three patients in whom an isolated bilateral anterior fornix infarction presented with an acute amnestic syndrome. Clinical presentation, differential diagnosis and MR images are discussed for each patient and vascular anatomy of the involved brain regions is also considered...
February 10, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29394470/serum-neurofilament-chain-light-as-diagnostic-biomarker-for-acute-cerebral-ischemia-promising-tool
#12
Mohamed Al-Khaled
The search for serum markers to detect acute and chronic cerebral damage has become of vital importance in the clinical diagnosis and the monitoring of neurological diseases. In the past few years many studies have found an elevated Neurofilmant Light Chain (sNfL) level in the cerebrospinal fluid among patients with chronic neurodegenerative diseases,[1-3] the concentration of the aforementioned marker in the serum and cerebrospinal fluid has been found to be associated with acute nerve damage, particularly in the central nervous system...
February 2, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29383812/socioeconomic-disparities-in-clinical-trials-on-alzheimer-s-disease-a-systematic-review
#13
Marco Canevelli, Giuseppe Bruno, Carlo Vico, Valerio Zaccaria, Eleonora Lacorte, Ivo Iavicoli, Nicola Vanacore, Matteo Cesari
BACKGROUND: There is now a wide consensus at recognizing social and economic circumstances as main determinants of the individual's health status. Nevertheless, characteristics relating to socioeconomic status (SES) are poorly described in research reports. The aim of the present review was to verify if the SES of participants is adequately reported in interventional studies targeting Alzheimer's disease (AD), and to explore the impact of SES proxy measures on the efficacy of the considered medications...
January 30, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29377594/spatial-epidemiology-of-amyotrophic-lateral-sclerosis-in-piedmont-and-aosta-valley-italy-a-population-based-cluster-analysis
#14
R Vasta, A Calvo, C Moglia, S Cammarosano, U Manera, A Canosa, F D'Ovidio, L Mazzini, A Chiò
BACKGROUND: The analysis of the spatial distribution of cases could give important cues on putative environmental causes of a disease. We aimed to perform a spatial analysis of a 20-years period ALS cohort from the Piedmont and Aosta Valley ALS register (PARALS). METHODS: Address at the moment of diagnosis was considered for each ALS case. Municipalities' and census divisions' resident populations during the 1995-2014 period were obtained. Cluster analysis was performed adopting both Moran's Index and the Kulldorff's spatial scan statistic...
January 27, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29377401/increased-expression-of-trem2-in-peripheral-cells-from-mild-cognitive-impairment-patients-that-progress-into-alzheimer-s-disease
#15
Martina Casati, Evelyn Ferri, Cristina Gussago, Paolo Mazzola, Carlo Abbate, Giuseppe Bellelli, Daniela Mari, Matteo Cesari, Beatrice Arosio
BACKGROUND: Neuroinflammation plays a role in the etiopathogenesis of Alzheimer's disease (AD). TREM2, a cell surface receptor of the immunoglobulin superfamily, seems to have protective anti-inflammatory activity in AD. METHODS: We analyzed TREM2 expression in peripheral blood mononuclear cells from healthy subjects (CT) and from patients with either AD or mild cognitive impairment (MCI). MCI were re-evaluated at a two-year follow-up to investigate their progression to AD (MCI-AD), or lack thereof (MCI-MCI)...
January 27, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29368362/nonalcoholic-fatty-liver-disease-an-emerging-predictor-of-stroke-risk-severity-and-outcome
#16
Marianthi Papagianni, Konstantinos Tziomalos
Nonalcoholic fatty liver disease (NAFLD) is defined as excessive intrahepatic fat accumulation in the absence of increased alcohol consumption or other causes of liver steatosis [1]. NAFLD is the commonest chronic liver disease in high-income countries and affects approximately 34-46% of the general population [2]. Patients with NAFLD have increased prevalence of both established cardiovascular risk factors, including type 2 diabetes mellitus and obesity, and emerging risk factors, including subclinical atherosclerosis and reduced adiponectin levels [3]...
January 25, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29360254/intravenous-thrombolysis-for-acute-ischaemic-stroke-in-patients-on-direct-oral-anticoagulants-expert-opinion-of-the-societe-francaise-de-neurologie-vasculaire-sfnv-french-vascular-neurology-society-and-the-groupe-francais-d-etudes-sur-l-hemostase-et-la-thrombose
#17
Emmanuel Touzé, Yves Gruel, Isabelle Gouin-Thibault, Emmanuel De Maistre, Sophie Susen, Pierre Sie, Laurent Derex
BACKGROUND AND PURPOSE: Whereas intravenous thrombolysis (IVT) is allowed in acute ischaemic stroke (IS) in patients on vitamin K antagonists if INR≤1.7, there is no similar recommendations for patients on direct oral anticoagulants (DOACs), notably due to the lack of coagulation tests to assess the therapeutic effects. Although the literature is scarce, consisting in small case series and retrospective studies, considering the frequency of this situation, the French Vascular Neurology Society and the French study Group on Haemostasis and Thrombosis have worked on a joined position paper to provide a practical position regarding emergency management of IS in patients on DOACs...
January 23, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29359374/value-of-clinical-features-to-differentiate-refractory-epilepsy-from-mimics-a-prospective-longitudinal-cohort-study
#18
Angelo Labate, Laura Mumoli, Antonio Curcio, Giovanni Tripepi, Graziella D'Arrigo, Edoardo Ferlazzo, Umberto Aguglia, Ciro Indolfi, Aldo Quattrone, Antonio Gambardella
BACKGROUND AND PURPOSE: Misdiagnosis of refractory epilepsy (rE) is common and such patients experience a long diagnostic delay. Our aim was to identify key clinical/laboratory factors in order to obtain an alternative diagnosis in patients referred for rE. METHODS: Between January 2010 and December 2015, 125 consecutive patients with a diagnosis of rE were prospectively enrolled. All patients underwent a comprehensive neurological, neuropsychiatric and cardiologic evaluation, and had an observation time of at least one year after the study entry...
January 22, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29356273/unknown-onset-strokes-with-anterior-circulation-occlusion-treated-by-thrombectomy-after-dwi-flair-mismatch-selection
#19
Simon Escalard, Benjamin Gory, Maéva Kyheng, Jean-Philippe Desilles, Hocine Redjem, Gabriele Ciccio, Stanislas Smajda, Julien Labreuche, Mikael Mazighi, Michel Piotin, Raphaël Blanc, Bertrand Lapergue, Robert Fahed
BACKGROUND AND PURPOSE: The DAWN Trial recently showed compelling evidence in treating late window and wake-up stroke patients with thrombectomy using a clinical-imaging mismatch. We aimed to evaluate the results of thrombectomy for unknown-onset strokes (UOS) treated in our centers after a DWI-FLAIR mismatch based selection. METHODS: We performed a multicenter, cohort study of consecutive UOS treated by thrombectomy between 2012 and 2016. We compared UOS with proximal anterior circulation occlusion discovered beyond 6 hours from "last seen normal" with known-onset strokes (KOS) for whom thrombectomy was started within 6 hours from onset...
January 21, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29356206/survey-of-diagnostic-and-treatment-practices-for-multiple-sclerosis-in-europe-part-2-progressive-ms-paediatric-ms-pregnancy-and-general-management
#20
Oscar Fernández, Mario Delvecchio, Gilles Edan, Sten Fredrikson, Gavin Giovannoni, Hans-Peter Hartung, Eva Havrdova, Ludwig Kappos, Carlo Pozzilli, Per Soelberg Soerensen, Björn Tackenberg, Patrick Vermersch, Giancarlo Comi
BACKGROUND AND PURPOSE: The European Charcot Foundation supported development of a set of surveys to understand current practice patterns for diagnosis and management of multiple sclerosis (MS) in Europe. Part 2 of the report summarises survey results related to secondary progressive MS (SPMS), primary progressive MS (PPMS), pregnancy, paediatric MS and overall patient management. METHODS: A steering committee of MS neurologists developed case- and practice-based questions for two sequential surveys distributed to MS neurologists throughout Europe...
January 21, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
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