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European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies

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https://www.readbyqxmd.com/read/29687559/-no-evidence-of-disease-activity-is-it-an-appropriate-surrogate-in-multiple-sclerosis
#1
Harald Hegen, Gabriel Bsteh, Thomas Berger
The increasing number of disease-modifying treatments available for multiple sclerosis (MS) has broadened treatment options for patients, but also challenges clinicians to select the best therapy for each individual at the appropriate stage of the disease. Early prediction of treatment response still remains one of the main difficulties in the management of MS patients. The concept of "no evidence of disease activity"(NEDA) has been proposed as surrogate for treatment response based on the absence of relapses, disability progression and radiological activity...
April 24, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29687522/scientific-publications-of-european-neurologists-a-survey-commissioned-by-the-european-academy-of-neurology
#2
Giorgio Cruccu, Gűnther Deuschl, Antonio Federico
BACKGROUND: Bibliometric searches may provide an indirect assessment of research in a field or country. The European Academy of Neurology decided to investigate how the article production was developing in European countries, as an indicator of neurological vitality. METHODS: We searched two databases, Scopus and PubMed, for articles published by authors belonging to neurological institutions in all European countries, USA, Brazil, China, and Japan. The search assessed the production in the period between 2000 and 2015...
April 23, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29683546/kappa-free-light-chains-in-cerebrospinal-fluid-to-identify-patients-with-oligoclonal-bands
#3
M Süße, M Hannich, A Petersmann, Stephanie Zylla, M Pietzner, M Nauck, A Dressel
OBJECTIVE: Gold standard for detection of intrathecal immunoglobulin synthesis is the measurement of oligoclonal bands (OCB). In the diagnosis of Multiple Sclerosis the kappa free light chains (KFLC) index has a similar sensitivity and specificity as OCB. This study investigated whether determination of the KFLC index could be used to predict the presence of OCB. METHODS: The KFLC index was determined prospectively from 295 paired serum and cerebrospinal fluid (CSF) samples...
April 23, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29683540/blood-pressure-levels-in-the-acute-phase-after-intracerebral-haemorrhage-are-associated-with-mortality-in-young-adults
#4
Satu Mustanoja, Jukka Putaala, Riku-Jaakko Koivunen, Ida Surakka, Turgut Tatlisumak
BACKGROUND: Blood pressure (BP) levels in acute Intracerebral haemorrhage (ICH) and mortality have not been thoroughly studied in the young. METHODS: The relationship between BP and mortality was assessed in consecutive first-ever, non-traumatic acute ICH patients ≤50 years of age, enrolled in the Helsinki ICH Young Study. BP parameters included systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP) and pulse pressure (SBP-DBP) at admission and 24 hours, and delta (admission-24 hour) BP parameters...
April 23, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29682863/early-management-of-medication-overuse-headache-to-remove-or-to-add-medication
#5
Christofer Lundqvist
Medication-overuse headache (MOH) is a chronic headache that usually develops from migraine or tension-type headache, in parallel with over-use of symptomatic headache medication. Despite the observation that the chronic headache usually resolves once over-use is stopped, it is a much debated entity, and there is no consensus regarding how to stop over-use or, whether the medication over-use is cause or consequence. This article is protected by copyright. All rights reserved.
April 23, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29682860/the-role-of-chronic-kidney-disease-and-atrial-fibrillation-on-outcomes-of-ischaemic-stroke-patients
#6
Ahsan A Khan, Gregory Y H Lip
Stroke is one of the leading causes of morbidity and mortality in the western world. Approximately 85% of strokes are ischaemic, caused by vascular occlusion either due to acute thrombus or emboli often as a result of atrial fibrillation (AF). Other age dependent conditions such as hypertension and diabetes mellitus lead to impairment of renal function and development of chronic kidney disease (CKD). Indeed, CKD is increasingly prevalent in the elderly population and is an independent predictor of stroke recurrence, mortality and poor clinical outcomes after acute ischaemic stroke (1)...
April 23, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29667271/syndrome-and-outcome-of-antibody-negative-limbic-encephalitis
#7
Francesc Graus, Domingo Escudero, Laura Oleaga, Jordi Bruna, Alberto Villarejo-Galende, Jordi Ballabriga, María Inés Barceló, Francisco Gilo, Stoyan Popkirov, Pavel Stourac, Josep Dalmau
OBJECTIVE: To report the clinical characteristics of 12 patients with limbic encephalitis (LE) who were antibody-negative after a comprehensive immunological study. METHODS: Review of clinical records of 163 patients with LE. Immunohistochemistry on rat brain, cultured neurons, and cell-based assays were used to identify neuronal autoantibodies. Patients were included if 1) there was adequate clinical, CSF, and MRI information to classify the syndrome as LE, 2) MRI images were accesible for central review, and 3) serum and CSF were available and confirmed negative for neuronal antibodies...
April 18, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29667266/application-of-the-dawn-clinical-imaging-mismatch-and-defuse-3-selection-criteria-benefit-seems-similar-but-restrictive-volume-cut-offs-might-omit-potential-responders
#8
Célina Ducroux, Naim Khoury, Augustin Lecler, Raphaël Blanc, Annaëlle Chetrit, Hocine Redjem, Gabriele Ciccio, Stanislas Smajda, Simon Escalard, Jean-Philippe Desilles, Mikaël Mazighi, Malek Ben Maacha, Michel Piotin, Robert Fahed
BACKGROUND: We aimed to conduct an external validation of the selection criteria of the diffusion-weighted-imaging or computerized-tomography-perfusion assessment with clinical mismatch in the triage of wake-up and late-presenting strokes undergoing Neurointervention with Trevo (DAWN) and the Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke (DEFUSE3) trials in a cohort of unknown onset stroke (UOS) patients treated with thrombectomy. METHODS: A validation cohort of UOS patients was selected from a prospectively collected thrombectomy database to match the inclusion criteria of DAWN and DEFUSE3...
April 18, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29660221/brainstem-leukoaraiosis-independently-predicts-poor-outcome-after-ischemic-stroke
#9
Eva Giralt-Steinhauer, Santiago Medrano, Carolina Soriano-Tárraga, Marina Mola-Caminal, Raquel Rasal, Elisa Cuadrado-Godia, Ana Rodríguez-Campello, Angel Ois, J Capellades, Jordi Jimenez-Conde, Jaume Roquer
BACKGROUND: Increased supratentorial white matter hyperintensities volume (S-WMHV) has been reported as a predictor of worse outcome in acute ischemic stroke (AIS) patients. However, few studies focus on less common locations such as brainstem-white matter hyperintensities (B-WMH), and their relationship with S-WMHV. This study aimed to examine whether B-WMH affects clinical outcome after AIS or transient ischemic attack (TIA). METHODS: Based on MRI evidence, B-WMH was evaluated in 313 prospectively identified patients with AIS/TIA and registered as absent or present...
April 16, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29633480/therapeutic-cannabinoids-in-multiple-sclerosis-immunomodulation-revisited
#10
Cris S Constantinescu, Pavel Gershkovich
Cannabinoids are compounds with pleiotropic properties that act on the cannabinoid receptors, CB1 and CB2, and are divided into endocannabinoids, the endogenous ligands of these receptors, synthetic cannabinoids and phytocannabinoids. The latter are derived from the plant Cannabis sativa. The therapeutic and psychoactive properties of this plant have been observed and used for centuries. Of the over 60 compounds that are unique to Cannabis sativa, the substances that have been attributed the greatest therapeutic potential are Δ9 - tetrahydrocannabinol (THC) and cannabidiol (CBD), both of which, used alone or combined with each other, have become approved drugs...
April 10, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29617060/a-prospective-real-world-analysis-of-onabotulinumtoxina-in-chronic-migraine-post-nice-u-k-technology-appraisal
#11
Anna P Andreou, Michele Trimboli, Adnan Al-Kaisy, Madeleine Murphy, Stefano Palmisani, Cherylin Fenech, Thomas Smith, Giorgio Lambru
OBJECTIVES: The National Institute for Health and Care Excellence (NICE) in the United Kingdom (UK) recommend the use of OnabotulinumtoxinA (BoNTA, Botox® ) in the management of chronic migraine (CM) following specific guidelines within the National Health Service (NHS). In view of the lack of data on the efficacy of this therapy following implementation of this guidelines in clinical practice and on the evaluation of guidance' compliance, we evaluate the effectiveness and safety of BoNTA in CM patients following the NICE guidelines...
April 4, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29611892/mlc901-neuroaid-ii-%C3%A2-for-cognition-after-traumatic-brain-injury-a-pilot-randomised-clinical-trial
#12
Alice Theadom, Suzanne Barker-Collo, Kelly M Jones, Priya Parmar, Rohit Bhattacharjee, Valery L Feigin
BACKGROUND: Treatments to facilitate recovery after traumatic brain injury (TBI) are urgently needed. To examine the safety and potential effects of herbal supplement MLC901 (NeuroAiD IITM ) on cognitive functioning following TBI, we conducted a nine-month pilot, randomised placebo-controlled clinical trial. METHODS: Adults aged 18-65 years, 1-12-months post-mild or moderate TBI, were randomised to receive MLC901 (0.8g capsules/day) or placebo for 6-months. The primary outcome was cognitive functioning assessed by the CNS-Vital Signs online neuropsychological test...
April 3, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29611888/decreasing-the-risk-of-sudep-structured-communication-of-risk-factors-for-premature-mortality-in-people-with-epilepsy
#13
Rohit Shankar, William Henley, Cailin Boland, Richard Laugharne, Brendan N McLean, Craig Newman, Jane Hanna, Samantha Ashby, Matthew C Walker, Josemir W Sander
BACKGROUND: Good practice guidelines highlight the importance of making people with epilepsy aware of the risk of premature mortality in epilepsy particularly due to Sudden Unexpected Death in Epilepsy (SUDEP). The SUDEP and Seizure Safety Checklist ("Checklist") is a structured risk communication tool used in UK clinics. It is not known if sharing structured information on risk factors allows individuals to reduce SUDEP and premature mortality risks. AIM: To ascertain if the introduction of the Checklist in epilepsy clinics lead to individual risk reduction...
April 3, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29611886/dose-optimisation-of-tacrolimus-with-therapeutic-drug-monitoring-and-cyp3a5-polymorphism-in-myasthenia-gravis-patients
#14
Di Chen, Shifang Hou, Ming Zhao, Xuelin Sun, Hua Zhang, Liping Yang
BACKGROUND AND PURPOSE: Tacrolimus was beneficial for treatment of myasthenia gravis (MG). And it has a narrow therapeutic range, therefore, therapeutic drug monitoring (TDM) is essential for tacrolimus to optimize dosage and prevent adverse reactions. However, no studies have explored the influencing factors of tacrolimus blood concentration in MG patients. Thus, we aimed to analyze the influencing factors and discuss how to optimal tacrolimus dosage for MG treatment. METHODS: The data of clinical characteristics, therapeutic drugs and adverse reactions of patients with MG who received tacrolimus were collected from 2013 to 2015 in Beijing Hospital...
April 3, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29611885/pregnancy-planning-and-outcomes-in-patients-with-multiple-sclerosis-after-mitoxantrone-therapy-a-monocentre-assessment
#15
Jessica Frau, Giancarlo Coghe, Paola Casanova, Claudia Sardu, Lorena Lorefice, Giuseppe Fenu, Maria Giovanna Marrosu, Eleonora Cocco
BACKGROUND: Persons with multiple sclerosis (MS) have many pregnancy-related doubts and fears. Careful counselling is thus important. Mitoxantrone (MITO) is used in patients with aggressive MS and may affect reproductive capacity. AIM: To investigate pregnancy planning and outcomes in MS patients treated with MITO, both before and after the treatment. MATERIALS: Patients with MS previously treated with MITO were recruited. Clinical, demographic, and treatment data were recorded...
April 3, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29604150/neurophysiological-study-of-critical-illness-polyneuropathy-and-myopathy-in-mechanically-ventilated-children-additional-aspect-into-pediatric-critical-illness-comorbidities
#16
Ahmed Thabet Mahmoud, Maha A M Tawfik, Sameh Abdallah Abd El Naby, Wafaa Moustafa M Abo El Fotoh, Nagwan Yossery Saleh, Nahla M Said Abd El Hady
BACKGROUND: Critical illness polyneuropathy and myopathy (CIP/CIM) is being increasingly recognized as a significant clinical problem in critically ill children especially who have spent long periods in the intensive care unit. So we aimed to determine the frequency of CIP/CIM among mechanically ventilated children and to analyze the associated risk factors and drawbacks frequently encountered in this cohort. METHODS: The study included 105 patients admitted to the pediatric intensive care unit and underwent mechanical ventilation for ≥7 days...
March 31, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29603839/humoral-immunity-response-to-herv-k-w-differentiates-between-amyotrophic-lateral-sclerosis-and-other-neurological-diseases
#17
Giannina Arru, Giuseppe Mameli, Giovanni Andrea Deiana, Anna Laura Rassu, Rosanna Piredda, Elia Sechi, Elisa Caggiu, Marco Bo, Enri Nako, Daniele Urso, Sara Mariotto, Sergio Ferrari, Gianluigi Zanusso, Salvatore Monaco, GianPietro Sechi, Leonardo A Sechi
BACKGROUND AND PURPOSE: Human endogenous retroviruses-K/W seem play a role in fostering and exacerbation of some neurological diseases, including amyotrophic lateral sclerosis (ALS). Given these findings, we investigated the immunity response against HERV-K and HERV-W envelope surface (env-su) glycoprotein antigens in serum and cerebrospinal fluid (CSF) of ALS, multiple sclerosis (MS) and Alzheimer's disease (AD) patients, and in healthy controls (HCs). METHODS: Four antigenic peptides derived respectively from HERV-K and HERV-W env surface proteins were studied in twenty-one definite or probable ALS, twenty-six possible or definite relapsing-remitting (RR) MS, eighteen patients with AD and thirty-nine HCs...
March 31, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29603515/cerebral-microbleeds-predict-infectious-intracranial-aneurysm-in-infective-endocarditis
#18
Sung-Min Cho, Robert J Marquardt, Cory J Rice, Andrew B Buletko, Lucy Q Zhang, Jean Khoury, Prateek Thatikunta, Julian Hardman, Dolora Wisco, Ken Uchino
BACKGROUND: MRI features such as cerebral microbleeds and sulcal susceptibility weighted imaging (SWI) or gradient-echo T2* (GRE-T2*) lesions in infective endocarditis (IE) have reported association with the presence of infectious intracranial aneurysm (IIA). We aimed to validate these MRI imaging predictors for IIA in order to better assist in assessing the appropriate indications for DSA. METHODS: The derivation cohort comprised IE patients with neurological evaluation and MRI and digital subtraction angiogram (DSA) at a single tertiary referral center from January 2015 to July 2016...
March 30, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29603513/risk-score-prediction-model-for-dementia-in-patients-with-type-2-diabetes
#19
Chia-Ing Li, Tsai-Chung Li, Chiu-Shong Liu, Li-Na Liao, Wen-Yuan Lin, Chih-Hsueh Lin, Sing-Yu Yang, Jen-Huai Chiang, Cheng-Chieh Lin
BACKGROUND: No study established a prediction dementia model in the Asian populations. This study aims to develop a prediction model for dementia in Chinese type 2 diabetes patients. METHODS: This retrospective cohort study included 27,540 Chinese type 2 diabetes patients (aged 50-94 years) enrolled in Taiwan National Diabetes Care Management Program. Participants were randomly allocated into derivation and validation sets at 2:1 ratio. Cox proportional hazards regression models were used to identify risk factors for dementia in the derivation set...
March 30, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29603501/association-of-serum-cystatin-c-with-neuromyelitis-optica-spectrum-disorders
#20
Yaqing Shu, Lei Zhang, Yanyu Chang, Rui Li, Xiaobo Sun, Jing Li, Haotian Wu, Yu Yang, Lisheng Peng, Zhengqi Lu, Allan G Kermode, Wei Qiu
BACKGROUND: The relationship between Cystatin C (CysC) and neuromyelitis optica spectrum disorders (NMOSD) is unknown. METHODS: Serum CysC levels were measured in 105 Chinese patients with NMOSD (53 in relapse, 52 NMOSD in remission) and 109 healthy controls (HCs). Association of CysC with NMOSD and its clinical and magnetic resonance imaging (MRI) parameters were evaluated. RESULTS: CysC levels were significantly lower in patients with relapsing NMOSD than those in remission (p < 0...
March 30, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
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