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European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies

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https://www.readbyqxmd.com/read/30489674/autonomic-dysfunction-in-hereditary-spastic-paraplegia-type-4
#1
Carelis González-Salazar, Karen A G Takazaki, Alberto R M Martinez, Luciana R Pimentel-Silva, Laís Alves Jacinto-Scudeiro, Érika Yumi Nakagawa, Camila Emi Fujiwara Murakami, Jonas Alex M Saute, José Luiz Pedroso, Orlando Graziani P Barsottini, Helio Teive, Marcondes C França
INTRODUCTION: SPAST mutations are the most common cause of hereditary spastic paraplegia (SPG4-HSP), which is characterized by progressive lower limb weakness, spasticity and hyperreflexia. There are few studies about non-motor manifestations in this disease and none about autonomic involvement. Therefore, our aim was to determine the frequency and pattern of autonomic complaints in patients with SPG4-HSP, as well as to determine the clinical relevance and the possible factors associated with these manifestations...
November 29, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/30489673/prevalence-and-short-term-changes-of-cognitive-dysfunction-in-young-ischemic-stroke-patients
#2
Daniela Pinter, Christian Enzinger, Thomas Gattringer, Sebastian Eppinger, Kurt Niederkorn, Susanna Horner, Simon Fandler, Markus Kneihsl, Kathrin Krenn, Gerhard Bachmaier, Franz Fazekas
BACKGROUND: Information on the prevalence and course of post-stroke cognitive impairment in young stroke patients is limited. We aimed to assess a consecutive sample of acute young ischemic stroke patients (18 to 55 years) for the presence and development of neuropsychological deficits. METHODS: Patients prospectively underwent a comprehensive clinical and cognitive assessment, examining general cognitive function, processing speed, attention, flexibility/executive function and word fluency within the first three weeks after hospital admission (median assessment at day six) and at a three months follow-up (FU)...
November 29, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/30472778/high-frequency-rtms-and-itbs-for-spasticity-management-in-secondary-progressive-multiple-sclerosis
#3
Julia Korzhova, Ilya Bakulin, Dmitry Sinitsyn, Alexandra Poydasheva, Natalia Suponeva, Maria Zakharova, Michael Piradov
BACKGROUND: The spasticity phenomenon is a significant factor in the development of disability. Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment method for this disorder. AIMS: Our aim was to compare the effects of two protocols of rTMS - the high-frequency (HF) rTMS (20 Hz) and the intermittent theta-burst stimulation (iTBS) - on the level of spasticity and concomitant symptoms in patients with secondary progressive multiple sclerosis (SPMS) with an analysis of the duration of the effects up to 12 weeks after the stimulation course...
November 25, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/30472766/safety-of-urgent-endarterectomy-in-acute-non-disabling-stroke-patients-with-symptomatic-carotid-artery-stenosis-an-international-multicenter-study
#4
Andromachi Roussopoulou, Georgios Tsivgoulis, Christos Krogias, Andreas Lazaris, Konstantinos Moulakakis, George S Georgiadis, Robert Mikulik, John D Kakisis, Christina Zompola, Simon Faissner, Maria Chondrogianni, Chrissoula Liantinioti, Thomas Hummel, Apostolos Safouris, Paraskevi Matsota, Constantinos Voumvourakis, Miltos Lazarides, George Geroulakos, Spyros N Vasdekis
BACKGROUND & PURPOSE: International recommendations advocate that carotid endarterectomy (CEA) should be performed within two weeks from the index event in symptomatic carotid artery stenosis (sCAS) patients. However, there are controversial data regarding the safety of CEA performed during the first two days of ictus. The aim of this international, multicenter study was to prospectively evaluate the safety of urgent (0-2 days) in comparison to early (3-14 days) CEA in patients with sCAS...
November 25, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/30471170/compliance-with-international-guidelines-for-chronic-inflammatory-neuropathies
#5
Yusuf A Rajabally, Peter van den Bergh
ERare diseases' management guidelines are produced with the primary aim of improving practice and standards of care for patients and may represent a useful framework for clinical practice. The EFNS/PNS (European Federation of Neurological Societies/Peripheral Nerve Society) guidelines for CIDP (chronic inflammatory demyelinating polyneuropathy) and MMN (multifocal motor neuropathy) were last published in 2010 (1, 2). Enthusiasm of the audience for whom they are produced, arguably primarily non-sub-specialists, is however largely unexplored...
November 24, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/30471162/-stroke-like-events-after-brain-radiotherapy-a-large-series-with-long-term-follow-up
#6
Anna Luisa Di Stefano, Giulia Berzero, François Ducray, Marica Eoli, Anna Pichiecchio, Lisa Maria Farina, Valeria Cuccarini, Marta Claudia Brunelli, Luca Diamanti, Stéphanie Condette Auliac, Andrea Salmaggi, Antonio Silvani, Bruno Giometto, Andrea Pace, Antonello Vidiri, Frederic Bourdain, Stefano Bastianello, Mauro Ceroni, Enrico Marchioni
BACKGROUND: Patients with history of brain radiotherapy can experience acute "stroke-like" syndromes related to the delayed effects of brain radiation, including "Stroke-like Migraine Attacks after Radiation Therapy (SMART)", "Peri-Ictal Pseudoprogression (PIPG)", and "Acute Late-onset Encephalopathy after Radiation Therapy (ALERT)" syndrome. The aim of this study is to collect evidence on the long-term outcome and treatment of these conditions, whose knowledge is undermined by their rarity and fragmented description...
November 24, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/30431216/diagnostic-usefulness-of-plexus-mri-in-chronic-inflammatory-demyelinating-polyradiculopathy-without-electrodiagnostic-criteria-of-demyelination
#7
Guillaume Fargeot, Karine Viala, Marie Theaudin, Marc-Antoine Labeyrie, Raquel Costa, Jean Marc Léger, David Adams, Christophe Vandendries, Celine Labeyrie
INTRODUCTION: The usefulness of plexus MRI in the diagnosis of chronic inflammatory demyelinating polyradiculopathy (CIDP) without definite EFNS/PNS electrodiagnostic criteria is currently unclear. METHODS: Data from consecutive patients with clinical manifestations suggesting CIDP, with or without (CIDP-D and CIDP-ND, respectively) definite EFNS/PNS electrodiagnostic criteria, and referred for plexus MRI in our imaging center were retrospectively analyzed. An expert committee of neurologists compared the level of suspicion of CIDP in CIDP-ND patients to the blinded/unblinded MRI findings...
November 15, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/30417962/sensitivity-of-mg-adl-for-generalized-weakness-in-myasthenia-gravis
#8
Robert H P de Meel, Wouter F Raadsheer, Erik W van Zwet, Jan J G M Verschuuren, Martijn R Tannemaat
INTRODUCTION: MG-ADL (Myasthenia Gravis Activities of Daily Living) is a commonly used questionnaire in MG trials. To investigate whether MG-ADL is equally sensitive to oculobulbar and generalized weakness, we analyzed its correlation with the oculobulbar and generalized domain of the quantitative myasthenia gravis (QMG) score (QMGob and QMGgen, respectively). To test whether the sensitivity of MG-ADL for generalized weakness could be improved, we investigated whether adding questions on generalized weakness would increase its correlation with QMGgen...
November 12, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/30414315/safety-and-efficacy-of-autologous-hematopoietic-stem-cell-transplantation-following-natalizumab-discontinuation-in-aggressive-multiple-sclerosis
#9
Alice Mariottini, Chiara Innocenti, Benedetta Forci, Eliana Magnani, Claudia Mechi, Alessandro Barilaro, Riccardo Nistri, Arianna Fani, Riccardo Saccardi, Luca Massacesi, Anna Maria Repice
BACKGROUND: Natalizumab (NTZ) is a highly effective treatment for relapsing-remitting multiple sclerosis (RRMS), but its withdrawal is often followed by disease reactivation or rebound, even if other disease-modifying treatments (DMTs) are administered. In this study, for the first time, safety and efficacy of autologous hematopoietic stem cell transplantation (aHSCT) performed following NTZ discontinuation was retrospectively compared with conventional DMTs. METHODS: Patients with RRMS treated with NTZ and who discontinued the drug after at least six administrations and with at least six months of follow-up were included...
November 10, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/30414314/mitochondrial-dna-haplogroups-and-age-at-onset-of-machado-joseph-disease-spinocerebellar-ataxia-type-3-a-study-in-patients-from-multiple-populations
#10
A Ramos, M Planchat, A R Vieira Melo, M Raposo, U Shamim, V Suroliya, A K Srivastava, M Faruq, H Morino, R Ohsawa, H Kawakami, L B Jardim, M L Saraiva-Pereira, J Vasconcelos, C Santos, M Lima
BACKGROUND: Mitochondrial dysfunction has been implicated in the pathogenesis of several neurodegenerative disorders, namely of Machado-Joseph disease, an autosomal dominant late-onset polyglutamine ataxia that results from an unstable expansion of a CAG tract in the ATXN3 gene. The size of the CAG tract only partially explains age at onset, highlighting the existence of disease modifiers. Mitochondrial DNA haplogroups have been associated with clinical presentation in other polyglutamine disorders, constituting potential modifiers of Machado-Joseph disease phenotype...
November 10, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/30414302/hemorrhagic-transformation-after-stroke-interrater-and-intrarater-agreement
#11
Adrien Guenego, Augustin Lecler, Jean Raymond, Candice Sabben, Naim Khoury, Kevin Premat, Daniele Botta, William Boisseau, Benjamin Maïer, Gabriele Ciccio, Hocine Redjem, Stanislas Smajda, Célina Ducroux, Lucas Di Meglio, Vincent Davy, Jean-Marc Olivot, Adrien Wang, Julien Duplantier, Margaux Roques, Sidney Krystal, Patricia Koskas, Adrien Collin, Malek Ben Maacha, Mylène Hamdani, Kevin Zuber, Raphaël Blanc, Michel Piotin, Robert Fahed
BACKGROUND: Hemorrhagic transformation (HT) is a complication of stroke that can occur spontaneously or after treatment. We aimed to assess the interrater and intrarater reliability of HT diagnosis. METHODS: Studies assessing the reliability of the European Cooperative Acute Stroke Study (ECASS) classification of HT or of the presence (yes/no) of HT were systematically reviewed. Eighteen raters independently examined 30 post-thrombectomy computed tomography scans selected from the Aspiration versus Stentriever (ASTER) trial...
November 10, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/30414301/comparing-two-classification-schemes-for-seizures-and-epilepsy-in-rural-china
#12
Feng Wang, Zhibin Chen, Indran Davagnanam, Chandrashekar Hoskote, Ding Ding, Wenzhi Wang, Bin Yang, Yingli Wang, Taiping Wang, Wenling Li, Josemir W Sander, Patrick Kwan
BACKGROUND: The International League Against Epilepsy (ILAE) updated the classifications of seizures and epilepsies in 2017. We compared the 2017 classifications with the 1980's classifications in rural China. METHODS: People with epilepsy were recruited from rural areas in China receiving treatment under the National Epilepsy Control Programme. Their seizures and epileptic syndrome were classified using the 1980's ILAE classification system and then re-classified according the 2017 system...
November 10, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/30414300/sapienza-global-bedside-evaluation-of-swallowing-after-stroke-the-globe-3s-study
#13
Massimiliano Toscano, Alessandro Viganò, Andrea Rea, Angela Verzina, Tullia Sasso D'Elia, Francesca Puledda, Lucia Longo, Valentina Mancini, Marco Ruggiero, Tommaso B Jannini, Giada Giuliani, Francesca Albino, Marta Altieri, Edoardo Vicenzini, Francesco Fattapposta, Flavia Pauri, Patrizia Giacomini, Giovanni Ruoppolo, Vittorio Di Piero
BACKGROUND AND PURPOSE: Dysphagia occurs in up to 50% of all acute stroke patients. There is debate regarding which is the most effective screening tool in identifying aspiration in acute stroke patients. We assessed the accuracy of the Sapienza Global Bedside Evaluation of Swallowing after Stroke (GLOBE-3S), which combines the TOR-BSST© with oxygen desaturation and laryngeal elevation measuring during swallowing. METHODS: We prospectively enrolled consecutive stroke patients within 72 hours of symptom onset...
November 10, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/30414299/clinical-course-of-multiple-sclerosis-and-labor-force-absenteeism-a-longitudinal-population-based-study
#14
Anna Castelo-Branco, Erik Landfeldt, Axel Svedbom, Emil Löfroth, Andrius Kavaliunas, Jan Hillert
BACKGROUND AND PURPOSE: Multiple sclerosis (MS) is a chronic neurological disease associated with substantial disability and morbidity. The objective of our study was to assess long-term consequences of MS clinical course on sick leave and disability pension. METHODS: Patients with relapse-remitting MS (RRMS), secondary progressive MS (SPMS), and primary progressive MS (PPMS) were identified through the Swedish Multiple Sclerosis Registry. We calculated the mean annual prevalence and number of sick leave and disability pension days by clinical course, age, and year pre and post diagnosis, and compared outcomes using Welch's t-tests and analysis-of-variance models, mixed-effects regression, and survival analysis...
November 10, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/30414298/dual-antiplatelet-therapy-reduced-stroke-risk-in-high-risk-transient-ischemic-attack-patients-assessed-by-abcd3-i-score
#15
Bo Song, Lulu Pei, Yuan Cao, Pei Chen, Hui Fang, Shilei Sun, Xiao Wang, Xuan Tian, Yinan Guo, Yuming Xu
BACKGROUND: Several clinical trials demonstrated that dual antiplatelet therapy benefited TIA patients with an ABCD2 score ≥4. The present study aims to investigate whether the ABCD3-I score could be a more appropriate tool for TIA patients' selection to use dual antiplatelet therapy in real-world experience. METHODS: We derived data from the TIA database of the First Affiliated Hospital of Zhengzhou University. The predictive outcome was ischemic stroke at 90-day...
November 10, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/30414297/increased-rate-of-acute-caesarean-sections-in-women-with-epilepsy-results-from-oppland-perinatal-database-in-norway
#16
Anette H Farmen, Jacob H Grundt, Jakob O Nakling, Petter Mowinckel, Karl O Nakken, Morten I Lossius
BACKGROUND: Studies in women with epilepsy (WWE) regarding pregnancy and labour-complications have disclosed contradictory results. Our purpose was to investigate whether WWE have a higher risk of acute caesarean section (CS) or pregnancy complications than women without epilepsy or women with other chronic diseases, and if we found a higher risk, explore potential explanations. METHODS: The study used prospectively registered obstetric data from Oppland Perinatal Database in the period 2001 - 2011, containing information on 18 244 births, including 110 singleton pregnancies in mothers with validated epilepsy...
November 10, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/30414289/association-of-serum-galectin-3-with-risks-of-death-and-vascular-events-in-acute-ischemic-stroke-patients-the-role-of-hyperglycemia
#17
Nimei Zeng, Aili Wang, Chongke Zhong, Xiaowei Zheng, Zhengbao Zhu, Tan Xu, Yanbo Peng, Hao Peng, Qunwei Li, Zhong Ju, Deqin Geng, Yonghong Zhang, Jiang He
OBJECTIVE: Whether the association between galectin-3 and stroke outcome is modified by fasting plasma glucose (FPG) is unknown. We aimed to evaluate the prognostic effect of galectin-3 among ischemic stroke patients stratified by FPG. METHODS: 3082 ischemic stroke patients were included in this study and serum galectin-3 was tested at baseline. The primary outcome was a composite outcome of death and vascular events, and secondary outcomes were death, stroke recurrence and vascular events within one-year after stroke...
November 10, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/30414288/executive-function-subdomains-are-associated-with-poststroke-functional-outcome-and-permanent-institutionalization
#18
Hanna M Laakso, Marja Hietanen, Susanna Melkas, Gerli Sibolt, Sami Curtze, Maarit Virta, Raija Ylikoski, Tarja Pohjasvaara, Markku Kaste, Timo Erkinjuntti, Hanna Jokinen
BACKGROUND: Impairment of executive functions (EFs) is a common cognitive symptom poststroke and affects independence in daily activities. Previous studies have often relied on brief cognitive tests not fully considering the wide spectrum of EF subdomains. We used a detailed assessment of EFs to examine which of the subdomains and tests have the strongest predictive value on poststroke functional outcome and institutionalization in long-term follow-up. METHODS: A subsample of 62 patients from the Helsinki Stroke Aging Memory Study was evaluated with a battery of 7 neuropsychological EF tests 3 months poststroke and compared to 39 healthy control subjects...
November 10, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/30362206/diagnostic-value-of-the-2017-mcdonald-criteria-in-patients-with-a-first-demyelinating-event-suggestive-of-relapsing-remitting-multiple-sclerosis
#19
De-Hyung Lee, Maren Peschke, Kathrin Susanne Utz, Ralf Andreas Linker
BACKGROUND: For the diagnosis of relapsing-remitting multiple sclerosis (RRMS), the revised 2017 McDonald criteria include cerebrospinal fluid (CSF)-specific oligoclonal bands (OCB) as new criterion for dissemination in time (DIT). Among others, one expectation on the new criteria is to marginalize the diagnosis of CIS thus allowing for a faster and at the same time still reliable diagnosis of RRMS. METHODS: In this study, we-re-analyze data from an unselected patient cohort with a typical CIS and DIS at a large German MS Center from 2013-2016 to compare differences in diagnosing RRMS with the 2017 versus 2010 McDonald criteria in everyday practice...
October 26, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/30358915/peri-lead-edema-after-dbs-surgery-for-parkinson-s-disease-a-prospective-mri-study
#20
Linda Borellini, Gianluca Ardolino, Giorgio Carrabba, Marco Locatelli, Paolo Rampini, Sara Sbaraini, Elisa Scola, Sabrina Avignone, Fabio Triulzi, Sergio Barbieri, Filippo Cogiamanian
OBJECTIVE: to define the prevalence and the characteristics of peri-electrode edema in a prospective cohort of patients undergoing deep brain stimulation (DBS) surgery and to correlate it with clinical findings. METHODS: we performed brain MRI between 7 and 20 days after surgery in 19 consecutive patients undergoing DBS surgery for Parkinson's disease. The T2-weighted hyperintensity surrounding DBS leads was characterized and quantified. Any evidence of bleeding around the lead was also evaluated...
October 25, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
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