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European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies

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https://www.readbyqxmd.com/read/29932266/eanm-ean-recommendations-for-the-use-of-brain-18-f-fluorodeoxyglucose-positron-emission-tomography-fdg-pet-in-neurodegenerative-cognitive-impairment-and-dementia-delphi-consensus
#1
Flavio Nobili, Javier Arbizu, Femke Bouwman, Alexander Drzezga, Federica Agosta, Peter Nestor, Zuzana Walker, Marina Boccardi
BACKGROUND: Recommendations for using FDG-PET to support the diagnosis of dementing neurodegenerative disorders are sparse and poorly structured. METHODS: We defined 21 questions on diagnostic issues and on semi-automated analysis to assist visual reading. Literature was reviewed to assess study design, risk of bias, inconsistency, imprecision, indirectness and effect size. Critical outcomes were sensitivity, specificity, accuracy, positive/negative predictive value, area under the receiving operating characteristic curve, and positive/negative likelihood ratio of FDG-PET in detecting the target conditions...
June 22, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29931723/cognitive-reserve-maps-the-core-loci-of-neurodegeneration-in-corticobasal-degeneration
#2
Valeria Isella, Stefano Giuseppe Grisanti, Francesca Ferri, Sabrina Morzenti, Cinzia Crivellaro, Monica Musarra, Carlo Ferrarese
BACKGROUND: Cognitively stimulating life experiences and activities are deemed to moderate the clinical impact of brain damage progressively building a neural and cognitive reserve (CR). CR has been studied extensively in various neurodegenerative disorders, but not in Corticobasal degeneration (CBD). METHODS: Using SPM8 we correlated years of education, as determinant of cognitive reserve, with tracer uptake on FDG-PET, as marker of neurodegeneration, in 35 patients with various phenotypes of CBD, including a cognitive-motor composite score or symptoms duration as covariates for controlling disease stage...
June 22, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29931718/multiple-sclerosis-and-epilepsy-much-more-than-a-coincidence
#3
Massimiliano Calabrese
Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system. Although inflammatory lesions of the white matter are the hallmark of the disease, several neuropathological and imaging studies have clearly confirmed that the grey matter is not spared by the disease. The most recent data suggest that a chronic meningeal inflammation leads to a subpial demyelination resulting in a surface-in gradient of neuronal loss. This article is protected by copyright. All rights reserved...
June 22, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29924481/mental-versus-physical-fatigue-after-subarachnoid-hemorrhage-differential-associations-with-outcome
#4
Anne M Buunk, Rob J M Groen, Rianne A Wijbenga, Aaltje L Ziengs, Jan D M Metzemaekers, J Marc C van Dijk, Jacoba M Spikman
BACKGROUND: Fatigue is a major consequence of subarachnoid hemorrhage (SAH), but the specific characteristics are unclear. Our objective was to investigate the nature of post-SAH fatigue (mental or physical) and to determine the relationship with functional outcome in the chronic stage. Also, the possible influence of mood disorders and acute SAH-related factors (SAH type and external cerebrospinal fluid (CSF) drainage) on the presence of fatigue was investigated. METHODS: Patients with an aneurysmal SAH (aSAH) or angiographically negative SAH (anSAH) were assessed 3 to 10 years post-SAH (N = 221)...
June 20, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29924461/short-term-external-counterpulsation-augments-cerebral-blood-flow-and-tissue-oxygenation-in-chronic-cerebrovascular-occlusive-disease
#5
Eva E Buschmann, Philipp Hillmeister, Anja Bondke Persson, David S Liebeskind, Lea Schlich, Robert Kamenzky, Andreas Busjahn, Ivo R Buschmann, Peter Bramlage, Andreas Hetzel, Matthias Reinhard
BACKGROUND: External counterpulsation improves cerebral perfusion velocity in acute stroke and may stimulate collateral artery growth. However, whether (non-acute) at-risk patients with high-grade carotid artery disease may benefit from counterpulsation needs to be validated. METHODS: Twenty-eight patients (71±6.5 years, 5 women) with asymptomatic unilateral chronic severe ICA stenosis (>70%) or occlusion were randomized to receive 20 min active counterpulsation followed by sham treatment or vice versa...
June 20, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29924456/hereditary-amyloidosis-related-to-transthyretin-v30m-hattr-v30m-disease-progression-in-treated-and-untreated-patients
#6
Isabel Conceição, Bruno Miranda, José Castro, Mamede de Carvalho
BACKGROUND: Hereditary amyloidosis related to transthyretin V30M (hATTR V30M) is a progressive length-dependent sensory-motor axonal neuropathy. Here, we aim to compare the disease progression of treated (liver transplant or tafamidis) versus untreated patients with hATTR V30M. METHODS: Eighty-one hATTR V30M patients were included: 27 untreated, 25 treated with liver transplantation (LT) and 29 undergoing tafamidis. Neuropathy was assessed at baseline, 12, 24 and 36 months after study entry...
June 20, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29924443/influence-of-lung-function-and-sleep-disordered-breathing-on-stroke-a-community-based-study
#7
Jingjing Zhang, Zhuoqing Gong, Ruohan Li, Ya Gao, Ying Li, Jiamei Li, Bin Yan, Gang Wang
BACKGROUND: Impaired lung function is regarded as a risk factor for stroke in patients with chronic obstructive pulmonary disease. However, the association between reduced lung function and incident stroke in a community-based population with sleep-disordered breathing (SDB) remains unknown. METHODS: We performed a prospective study within the Sleep Heart Health Study cohort. Full montage home sleep testing and spirometry data on 2082 and 2072 individuals with and without SDB, respectively, were analysed...
June 20, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29904974/anti-glycine-receptor-antibody-related-disease-a-case-series-and-literature-review
#8
Andrew Swayne, Linda Tjoa, Simon Broadley, Sasha Dionisio, David Gillis, Leslie Jacobson, Mark R Woodhall, Andrew McNabb, Daniel Schweitzer, Ben Tsang, Angela Vincent, Sarosh R Irani, Richard Wong, Patrick Waters, Stefan Blum
INTRODUCTION: Antibodies to glycine receptors (GlyR-Abs) were first defined in progressive encephalopathy with rigidity and myoclonus (PERM), but subsequently identified in other clinical presentations. We aimed to assess the clinical associations of all patients identified with GlyR-Abs in Queensland, Australia between April 2014 to May 2017, and compared these to cases reported in the literature. METHODS: A literature review identified the clinical features of all published GlyR-Ab positive cases through online databases...
June 15, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29904963/experience-of-a-single-center-in-the-conservative-approach-of-20-consecutive-cases-of-asymptomatic-extracranial-carotid-artery-aneurysms
#9
V E C Pourier, J C Welleweerd, L J Kappelle, G J E Rinkel, Y M Ruigrok, H B van der Worp, T H Lo, M L Bots, F L Moll, Gert J de Borst
BACKGROUND: The clinical course and optimal treatment strategy for asymptomatic aneurysms of the extracranial carotid artery (ECAA) are unknown. We report our single-center experience with conservative management of patients with an asymptomatic ECAA. METHODS: A search in our hospital records from 1998 to 2013 revealed 20 patients (mean age 52 years, SD 12.5) with 23 ECAA, defined as a 150% or more fusiform dilation or any saccular dilatation compared to the healthy internal carotid artery...
June 14, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29855121/efficacy-and-safety-of-dual-antiplatelet-therapy-in-the-elderly-for-stroke-prevention-a-systematic-review-and-meta-analysis
#10
Lingling Ding, Bin Peng
BACKGROUND AND PURPOSE: There is a lack of age-specific evidence regarding the efficacy and safety of dual antiplatelet therapy (DAPT). We conducted a systematic review and meta-analysis for dual versus mono antiplatelet therapy in elderly patients with ischemic stroke (IS) or transient ischemic attack (TIA). METHODS: We searched PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials for relevant studies. Risk ratios (RR) for the outcomes of stroke recurrence, major bleeding and intracranial bleeding were calculated based on the DerSimonian and Laird random effects model...
June 1, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29851435/clinical-activity-after-fingolimod-cessation-disease-reactivation-or-rebound
#11
J Frau, M P Sormani, A Signori, S Realmuto, D Baroncini, P Annovazzi, E Signoriello, G Maniscalco, S La Gioia, C Cordioli, B Frigeni, S Rasia, G Fenu, R Grasso, A Sartori, R Lanzillo, M L Stromillo, S Rossi, B Forci, E Cocco
OBJECTIVE: There is debate as to whether the apparent rebound after fingolimod discontinuation is related to the discontinuation itself, or if it is due to the natural course of highly active multiple sclerosis (MS). We aimed to survey the prevalence of severe reactivation and rebound after discontinuation of fingolimod in a cohort of Italian patients with MS. METHODS: Patients with relapsing-remitting MS (RRMS) who were treated with fingolimod for at least 6 months and who stopped treatment for reasons that were unrelated to inefficacy were included in the analysis...
May 31, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29847005/early-versus-later-treatment-start-in-multiple-sclerosis-a-register-based-cohort-study
#12
T Chalmer, L M Baggesen, M Nørgaard, N Koch-Henriksen, M Magyari, P S Sorensen
OBJECTIVE: To assess long-term treatment effectiveness of disease-modifying therapy (DMT) initiated in early disease course versus later treatment start. METHODS: We included all Danish multiple sclerosis (MS) patients treated with DMT through two nationwide population-based MS registries. Patients were categorized as early treated if treatment started within two years after the first MS symptom (n=2,316) and later treated patients if treatment started between two and eight years after clinical onset (n=1,479)...
May 30, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29806963/neural-correlates-of-gait-variability-in-people-with-multiple-sclerosis-with-fall-history
#13
Alon Kalron, Gilles Allali, Anat Achiron
BACKGROUND AND PURPOSE: Investigate the association between step time variability and related brain structures in accordance with fall status in people with multiple sclerosis (PwMS). METHODS: The study included 225 PwMS. A whole-brain MRI was performed by a high-resolution 3.0-Telsa MR scanner in addition to volumetric analysis based on 3D T1-weighted images using the FreeSurfer image analysis suite. Step time variability was measured by an electronic walkway. Participants were defined as "fallers" (at least two falls during the previous year) and "non-fallers"...
May 28, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29806962/first-comprehensive-tool-for-screening-pain-in-parkinson-s-disease-the-king-s-parkinson-s-disease-pain-questionnaire-kppq
#14
Pablo Martinez-Martin, Alexandra M Rizos, John Wetmore, Angelo Antonini, Per Odin, Suvankar Pal, Rani Sophia, Camille Carroll, Davide Martino, Cristian Falup-Pecurariu, Belinda Kessel, Thomasin Andrews, Dominic Paviour, Claudia Trenkwalder, Kallol Ray Chaudhuri
BACKGROUND: Pain is highly prevalent in Parkinson's disease (PD), impacting patients' ability, mood, and quality of life. Detecting the presence of pain in its multiple modalities is necessary for adequate personalized management of PD. A 14-item, PD-specific, patient-based questionnaire (the King's Parkinson's disease Pain Questionnaire, KPPQ) was designed corresponding to the rater-based KPP Scale (KPPS). The present multi-center study was aimed at testing the validity of this screening tool...
May 28, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29802779/validation-of-a-short-cognitive-battery-to-screen-for-fitness-to-drive-of-persons-with-ms
#15
Abiodun E Akinwuntan, Deborah Backus, James Grayson, Hannes Devos
BACKGROUND: Some symptoms of multiple sclerosis (MS) affect driving. In a recent study, performance on five cognitive tests predicted on-road test performance of individuals with relapsing remitting MS with 91% accuracy, 70% sensitivity, and 97% specificity. However, the accuracy with which the battery will predict driving performance of a different cohort that includes all types of MS is unknown. METHOD: Participants (N=118; 48 ± 9 years; 97 females) performed a comprehensive off-road evaluation that lasted about 3 hours and a standardized on-road test that lasted approximately 45 minutes over a two-day period within the same week...
May 26, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29802670/reliability-and-main-findings-of-the-fees-tensilon-test-in-patients-with-myasthenia-gravis-and-dysphagia
#16
Sun Im, Sonja Suntrup-Krueger, Sigrid Colbow, Sonja Sauer, Inga Claus, Sven G Meuth, Rainer Dziewas, Tobias Warnecke
BACKGROUND AND PURPOSE: Diagnosis of pharyngeal dysphagia caused by myasthenia gravis (MG) based on clinical examination alone is often challenging. Flexible endoscopic evaluation of swallowing (FEES) combined with Tensilon (edrophonium) application, referred to as the FEES-Tensilon Test, was developed to improve diagnostic accuracy and to detect the main symptoms of pharyngeal dysphagia in MG. Here we investigated inter- and intra-rater reliability of the FEES-Tensilon Test and analyzed the main endoscopic findings...
May 26, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29797629/cognitive-impairment-in-early-stages-of-multiple-sclerosis-is-associated-with-high-cerebrospinal-fluid-levels-of-chi3l1-and-nf-l
#17
E Quintana, C Coll, J Salavedra-Pont, M Muñoz-San Martín, R Robles-Cedeño, J Tomàs-Roig, M Buxó, C Matute-Blanch, L M Villar, X Montalban, M Comabella, H Perkal, J Gich, L L Ramió-Torrentà
BACKGROUND/OBJECTIVE: Chitinase 3-like 1 (CHI3L1) and neurofilament light chain (NF-L) are promising biomarkers of disability in multiple sclerosis (MS); however, their role in cognitive dysfunction remains elusive. Here, we aimed to correlate cerebrospinal fluid (CSF) levels of CHI3L1 and NF-L with cognitive status in MS. METHODS/RESULTS: Fifty one recently diagnosed patients were cognitively evaluated and CSF was collected. Levels of CHI3L1 and NF-L were determined by ELISA...
May 24, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29790244/relapsing-acute-disseminated-encephalomyelitis-followed-by-optic-neuritis-in-children-a-clinical-entity-associated-with-anti-mog-antibody
#18
EDITORIAL
F Brilot
No abstract text is available yet for this article.
May 23, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29782693/multidomain-intervention-for-the-prevention-of-cognitive-decline-after-stroke-a-pooled-patient-level-data-analysis
#19
Yvonne Teuschl, Hege Ihle-Hansen, Karl Matz, Alexandra Dachenhausen, Paulina Ratajczak, Jaakko Tuomilehto, Marie Helene Ursin, Guri Hagberg, Bente Thommessen, Anne Rita Øksengård, Michael Brainin
BACKGROUND: The aim of this pooled patient-level data analysis was to test if multidomain interventions, addressing several modifiable vascular risk factors simultaneously, is more effective than usual post-stroke care for the prevention of cognitive decline after stroke. METHODS: This pooled patient-level data analysis includes two randomised controlled trials using a multidomain approach to target vascular risk factors in stroke patients and cognition as primary outcome...
May 21, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29772097/would-intravitreal-bevacizumab-injection-increase-risk-of-cerebral-infarction
#20
Jin-Woo Kwon, Donghyun Jee, Seong Hoon Lim
PURPOSE: Although studies have evaluated the relationship between intravitreal bevacizumab (IVB) injection and cerebral infarction(CI), the effects of IVB on CI are still not clear. The aim of this study was therefore to investigate the effects of IVB injection on CI patients with age-related macular degeneration (AMD). METHODS: We retrospectively reviewed patients with AMD who received IVB injections for 1 year and determined the incidence of CI within 60 days after IVB injection to analyze the possible association between IVB and CI...
May 17, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
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