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European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies

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https://www.readbyqxmd.com/read/29222957/association-between-%C3%AE-cell-function-estimated-by-homa-%C3%AE-and-prognosis-of-nondiabetic-patients-with-ischaemic-stroke
#1
Mengyuan Zhou, Yuesong Pan, Jing Jing, Yongjun Wang, Xingquan Zhao, Liping Liu, Hao Li, Yilong Wang
BACKGROUND AND PURPOSE: Studies showed β-cell dysfunction was associated with increased risk of cardiovascular disease and subclinical carotid atherosclerosis. This study aimed to investigate the association between β-cell function and prognosis of nondiabetic patients with ischaemic stroke. METHODS: Ischaemic stroke patients without diabetes in the Abnormal Glucose Regulation in Patients with Acute Stroke across China registry were included in this analysis. Homeostasis assessment of β-cell function (HOMA-β), was performed and classified it into four groups according to quartiles...
December 9, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29222955/brain-comorbidities-in-normal-pressure-hydrocephalus
#2
Gilles Allali, Magali Laidet, Stéphane Armand, Frédéric Assal
BACKGROUND: This cross-sectional study aims to compare gait changes after CSF tap test between normal pressure hydrocephalus patients with and without brain comorbidities (respectively NPH+ and NPH); and then identify significant contributors to poor CSF tap test among individuals with NPH+. METHODS: Gait changes (during single and dual task of backward counting) were quantified before and 24 hours after CSF tap test with an optoelectronic system in 52 NPH patients (77...
December 9, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29222944/cerebral-microbleeds-an-mri-review-of-common-and-less-common-causes
#3
REVIEW
Dimitri Renard
Cerebral microbleeds (CMB) are small foci of (acute, subacute, or chronic) blood products, best seen using MRI techniques sensitive to iron deposits (i.e. gradient-echo T2*-weighted and susceptibility-weighted imaging), frequently encountered in small vessel disease (SVD, with hypertensive vasculopathy and cerebral amyloid angiopathy as most frequent conditions) and also in other disorders. In this review, we will mainly discuss the MRI characteristics of CMB and the associated MRI abnormalities encountered in common and less common SVD and non-SVD conditions...
December 9, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29218822/european-academy-of-neurology-european-stroke-organisation-consensus-statement-and-practical-guidance-for-pre-hospital-management-of-stroke
#4
A Kobayashi, A Czlonkowska, G A Ford, A C Fonseca, G J Luijckx, J Korv, N Pérez de la Ossa, C Price, D Russell, A Tsiskaridze, M Messmer-Wullen, J De Keyser
Reduction of delay between onset and hospital arrival and adequate pre-hospital care of persons with acute stroke are important for improving chances of a favorable outcome. The objective is to recommend evidence-based practices for the management of patients with suspected stroke in the pre-hospital setting. The GRADE (Grading of Recommendations Assessment, Development and Evaluation) methodology was used to define the key clinical questions. An expert panel then reviewed the literature, established the quality of the evidence, and made recommendations...
December 7, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29218790/embolic-strokes-of-undetermined-source-in-young-adults-baseline-characteristics-and-long-term-outcome
#5
Nicolas Martinez-Majander, Karoliina Aarnio, Jani Pirinen, Tuomas Lumikari, Tuomo Nieminen, Mika Lehto, Juha Sinisalo, Markku Kaste, Turgut Tatlisumak, Jukka Putaala
BACKGROUND: Embolic strokes of undetermined source (ESUS) is a recent entity, not yet thoroughly investigated in young stroke patients. We compared clinical characteristics and long-term risks of vascular events and all-cause mortality between young-onset ESUS and other etiological subgroups. METHODS: Among the 1008 patients aged 15 to 49 years with first-ever ischemic stroke in Helsinki Young Stroke Registry, we identified ESUS patients, and defined primary endpoints as recurrent stroke, composite vascular events, and all-cause mortality...
December 7, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29215769/can-a-cognitive-rehabilitation-program-in-early-stages-of-parkinson-s-disease-improve-cognition-and-apathy-and-brain-functional-connectivity-for-up-to-18-months
#6
Antonio Daniele, Francesco Panza
In patients with Parkinson's disease (PD), management of non-motor symptoms, including cognitive and behavioural symptoms, is still a challenging need [1], which may be approached by various therapeutic strategies. A randomized controlled trial (RCT) in PD patients showed that a 13-week cognitive rehabilitation program training various cognitive functions (attention, memory, language, executive functions, social cognition) may improve cognition and functional disability [2]. Diez-Cirarda et al. [3] report the results obtained in 15 PD patients in early disease stages, as 18-month follow-up study of such RCT [2]...
December 7, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29205701/antibody-response-to-seasonal-influenza-vaccination-in-multiple-sclerosis-patients-receiving-immunomodulatory-therapy
#7
Henning K Olberg, Geir Egil Eide, Rebecca J Cox, Åsne Jul-Larsen, Sarah Larteley Lartey, Christian A Vedeler, Kjell-Morten Myhr
BACKGROUND: We have previously shown that multiple sclerosis patients receiving immunomodulatory treatment have reduced seroprotection rates after influenza immunization. OBJECTIVES: To further investigate the influence of immunomodulatory therapies on the antibody response and seroprotection rates in patients immunized with seasonal influenza vaccine in 2012/2013 compared to healthy controls. METHODS: Ninety patients receiving fingolimod, glatiramer acetate, interferon beta-1a/1b, natalizumab or no therapy were compared to 62 healthy controls...
December 4, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29205690/refinement-of-detecting-atrial-fibrillation-in-stroke-patients-results-from-the-track-af-study
#8
Florian Reinke, Markus Bettin, Linda Sarah Ross, Simon Kochhäuser, Ilka Kleffner, Martin Ritter, Jens Minnerup, Dirk Dechering, Lars Eckardt, Ralf Dittrich
BACKGROUND: Detection of occult atrial fibrillation (AF) is crucial for optimal secondary prevention in stroke patients. We determined the AF detection rate by implantable cardiac monitor (ICM) compared to the prediction rate of the probability of incident AF by software based analysis of continuously monitored ECG at follow up (Stroke risk analysis=SRA) and propose an optimized AF detection algorithm by combining both tools. METHODS: In a monocentric prospective study we investigated 105 out of 389 patients with cryptogenic stroke despite extensive diagnostic workup with two additional cardiac monitoring tools: (a) 20 month monitoring by ICM and (b) SRA during hospitalization at the Stroke Unit...
December 4, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29194869/muscle-strength-and-motor-function-throughout-life-in-a-cross-sectional-cohort-of-180-patients-with-sma-types-1c-4
#9
Renske I Wadman, Camiel A Wijngaarde, Marloes Stam, Bart Bartels, Louise A M Otto, Henny H Lemmink, Marja A G C Schoenmakers, Inge Cuppen, Leonard H van den Berg, W Ludo van der Pol
BACKGROUND: Natural history studies in SMA have primarily focused on infants and children. Natural history studies encompassing all age groups and SMA types are important for the interpretation of treatment effects of recently introduced SMN augmenting therapies. METHODS: We conducted a cross-sectional study to investigate muscle strength, Hammersmith Functional Motor Scale (Expanded) scores and the patterns of muscle weakness in relation to age and SMA type. RESULTS: We included 180 patients with SMA types 1-4 in the age range 1-77...
November 30, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29194859/a-nationwide-epidemiological-study-of-myasthenia-gravis-in-latvia
#10
Anete Zieda, Kristine Ravina, Ieva Glazere, Lelde Pelcere, Maruta S Naudina, Lelde Liepina, Inese Kamsa, Natalja Kurjane, Mark Woodhall, Leslie Jacobson, M Isabel Leite, Kokil Tandon, Viktorija Kenina
BACKGROUND AND PURPOSE: Myasthenia gravis (MG) is an autoimmune disorder characterized by fatigable muscle weakness due to of antibody-mediated impairment of neuromuscular transmission. The aim of this study was to investigate the incidence and prevalence of MG in Latvia, and to characterize this population by well-established clinical parameters such as age at onset, presence of associated antibodies, and thymus pathology. METHODS: cases of patients with known MG or presenting with first MG symptoms within the time period from 1 January 2010 to 31 December 2014 were selected from the database of the Neuromuscular Disease Clinic of Pauls Stradins Clinical University Hospital and Children's Clinical University Hospital...
November 30, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29194856/toronto-clinical-neuropathy-score-is-valid-for-a-wide-spectrum-of-polyneuropathies
#11
Alon Abraham, Carolina Barnett, Hans D Katzberg, Leif E Lovblom, Bruce A Perkins, Vera Bril
BACKGROUND: The Toronto Clinical Neuropathy Score (TCNS) is a valid and reliable scale for the diagnosis and staging of diabetic sensorimotor polyneuropathy. In this study, we aimed to explore the performance of the TCNS in non-diabetic polyneuropathies. METHODS: We performed a prospective study from November 2016 to May 2017 of patients with non-diabetic polyneuropathy. Patients had clinical, electrophysiological and functional assessments of their polyneuropathy, and the findings were correlated with the TCNS...
November 30, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29193488/a-path-to-understanding-autoimmune-gfap-astrocytopathy
#12
Anastasia Zekeridou, Andrew McKeon, Eoin P Flanagan
Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy was first described in humans in 2016 at the Mayo Clinic, USA and has been confirmed independently in Europe and Asia within the last year.[1-4] This disorder manifests as a distinctive corticosteroid-responsive meningoencephalomyelitis or limited form thereof, with lymphocytic pleocytosis often accompanied by a hallmark brain linear perivascular radial gadolinium enhancement.[1-4] It can be accompanied by a neoplasm in 20% (usually teratoma)...
November 29, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29193480/rhabdomyolysis-and-fluctuating-asymptomatic-hyperckemia-associated-with-cacna1s-variant
#13
Charenya Anandan, Mark A Cipriani, Ruple S Laughlin, Zhiyv Niu, Margherita Milone
BACKGROUND AND PURPOSE: CACNA1S encodes Cav 1.1, a voltage sensor for muscle excitation-contraction coupling, which activates the ryanodine receptor 1 (RYR1) leading to calcium release from the sarcoplasmic reticulum. CACNA1S mutations cause hypokalemic periodic paralysis, malignant hyperthermia and congenital myopathy. RYR1 mutations result in congenital myopathy, malignant hyperthermia and rhabdomyolysis. METHODS: To describe a novel phenotype associated with a CACNA1S variant at a site previously linked to hypokalemic periodic paralysis...
November 29, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29193473/autoimmune-glial-fibrillary-acidic-protein-astrocytopathy-in-chinese-patients-a-retrospective-study
#14
Youming Long, Junyan Liang, Huiming Xu, Qingmei Huang, Jie Yang, Cong Gao, Wei Qiu, Shaopeng Lin, Xiaohui Chen
OBJECTIVE: We aimed to describe the clinical, radiological, and pathological features of an autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy. METHODS: Data from 19 patients with positive GFAP-IgG in cerebrospinal fluid (CSF) were retrospectively analyzed. RESULTS: The main disease manifestations included myelitis (68.4%), headache (63.2%), abnormal vision (63.2%), fever (52.6%), ataxia (36.8%), psychosis (31.6%), dyskinesia (15...
November 29, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29193455/the-parkinson-s-disease-composite-scale-results-of-the-first-validation-study
#15
Fabrizio Stocchi, Fabiana G Radicati, K Ray Chaudhuri, Anders Johansson, Chandrasekhara Padmakumar, Cristian Falup-Pecurariu, Pablo Martinez Martin
OBJECTIVE: Validate the Parkinson's disease (PD) composite scale (PDCS). METHODS: The study included One hundred ninety four PD patients in five countries. Investigators completed the following scales: PDCS, MDS-UPDRS, PDSS-2, MoCA, WOK-19, SEND-PD and CISI-PD. For test-retest analysis, a second administration of the PDCS was carried out in 61 stable patients (as per the CISI-PD) in 7 to 14 days after the first evaluation. The PDCS is a novel scale for PD with a total of 17 items divided in 4 domains: motor, non-motor, treatment complication and disability...
November 29, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29193501/subspecialty-preferences-among-neurologists-of-the-future
#16
Panagiotis Zis, Antonella Macerollo, Anna Sauerbier, Viktoria Papp, Lisa Klingelhoefer, Hannah R Cock
INTRODUCTION: In the era of neurological subspecialization, most neurologists will have a field of specialist interest. The aim of this cross-sectional multi-national study was to identify the key areas of interest among trainees or junior specialists, assess the potential influence of an interest in research, and consider the results in light of population needs. METHODS: A total of 300 residents and junior neurologists who received a bursary to attend the European Academy of Neurology conference were invited to participate in this study...
November 28, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29193500/stroke-patients-with-familial-hypercholesterolemia-need-for-detection-and-aggressive-treatment
#17
Haralampos Milionis
Familial hypercholesterolaemia (FH) is an autosomal dominant disorder originating from mutations in genes encoding low density lipoprotein (LDL)-receptor, apolipoprotein B (apoB), or proprotein convertase subtilisin/kexin type 9 (PCSK9), thus resulting in severe elevations of total and LDL cholesterol levels. Heterozygous FH (HeFH) occurs in 1 in 250 people, whereas homozygous FH (HoFH) is very rare, occurring in about 1 in 160,000 to one million people worldwide [1]. Despite the fact that FH is a relatively rare disease, it is of profound medical interest by serving as a model disease for atherosclerosis...
November 28, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29171146/onabotulinumtoxina-in-chronic-migraine-predictors-of-response-a-prospective-multicentre-descriptive-study
#18
Clara Domínguez, Patricia Pozo-Rosich, Marta Torres-Ferrús, Natalia Hernández-Beltrán, Carmen Jurado-Cobo, Carmen González-Oria, Sonia Santos, María José Monzón, Germán Latorre, Luis Carlos Álvaro, Ana Gago, Mercedes Gallego, Vicente Medrano, Mariano Huerta, Jessica García-Alhama, Roberto Belvís, Yago Leira, Rogelio Leira
BACKGROUND: OnabotulinumtoxinA is a treatment specifically approved for the prophylaxis of chronic migraine in adults. The aim of this study was to assess the effectiveness of OnabotulinumtoxinA in chronic migraine after 1 year of treatment in the real-life setting and to identify clinical predictors of outcome. METHODS: We designed a prospective multicentre study performed in 13 Hospitals in Spain. Patients underwent a complete medical history and examination. They received treatment with OnabotulinumtoxinA every 12 weeks over a year...
November 24, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29171132/structured-education-to-improve-primary-care-management-of-headache-how-long-do-the-benefits-last-a-follow-up-observational-study
#19
Mark Braschinsky, Sulev Haldre, Mart Kals, Marge Arge, Bruno Saar, Maris Niibek, Zaza Katsarava, Timothy J Steiner
BACKGROUND: Our earlier study showed that structured education of general practitioners (GPs) improved their practice in headache management. Here we assess duration of this effect. METHODS: In a follow-up observational study in Southern Estonia, subjects were the same six GPs as previously, managing patients presenting with headache as the main complaint. Data reflecting their practice were collected prospectively during a 1-year period commencing 2 years after the educational intervention...
November 24, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29171121/insular-damage-new-onset-atrial-fibrillation-and-outcome-after-acute-intracerebral-hemorrhage
#20
L Prats-Sánchez, D Guisado-Alonso, C Painous, F Fayos, E Pascual-Goñi, R Delgado-Mederos, A Martínez-Domeño, P Camps-Renom, J Martí-Fàbregas
BACKGROUND: Cortical insular damage is associated with cardiac arrhythmias and an increased risk of death. We investigated the influence of insular damage on the outcome of patients with acute intracerebral hemorrhage (ICH) as well as the frequency and predictors of new-onset atrial fibrillation (nAF). METHODS: We studied consecutive patients with ICH from 2013 to 2016. We identified those patients who underwent continuous electrocardiographic monitoring (≥24 hours), known AF and recent ischemic stroke...
November 24, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
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