journal
https://read.qxmd.com/read/38514096/impact-of-obesity-progression-or-regression-on-the-longitudinal-assessment-of-fibrosing-ild
#1
LETTER
Hadeel Alqurashi, Mathieu Marillier, Igor Neder-Serafini, Anne-Catherine Bernard, Onofre Moran-Mendoza, J Alberto Neder
No abstract text is available yet for this article.
March 21, 2024: European Respiratory Journal
https://read.qxmd.com/read/38514095/th2-skewed-peripheral-t-helper-cells-drives-b-cells-in-allergic-bronchopulmonary-aspergillosis
#2
JOURNAL ARTICLE
Rong-Guang Luo, Yi-Fan Wu, Hai-Wen Lu, Dong Weng, Jia-Yan Xu, Le-Le Wang, Li-Sha Zhang, Cai-Qi Zhao, Jian-Xiong Li, Yong Yu, Xin-Ming Jia, Jin-Fu Xu
INTRODUCTION: Patients with allergic bronchopulmonary aspergillosis (ABPA) suffer from repeated exacerbations. However, the involvement of T cell subsets remains unclear. METHODS: We enrolled ABPA patients, asthma patients and healthy controls. Th1, Th2, Th17, Treg and IL-21+ CD4+ T cells in total or sorted subsets of peripheral blood mononuclear cells (PBMCs) and ABPA Bronchoalveolar Lavage fluid (BALF) were analyzed by flow cytometry. RNA sequencing of subsets of CD4+ T cells were done in exacerbated ABPA patients and healthy controls...
March 21, 2024: European Respiratory Journal
https://read.qxmd.com/read/38514094/pulmonary-vascular-phenotype-identified-in-patients-with-gdf2-bmp9-or-bmp10-variants-an-international-multicentre-study
#3
JOURNAL ARTICLE
Julien Grynblat, Harm-Jan Bogaard, Mélanie Eyries, Olivier Meyrignac, Laurent Savale, Xavier Jais, Maria-Rosa Ghigna, Lucas Celant, Lilian Meijboom, Arjan Houweling, Marilyne Levy, Fabrice Antigny, Ari Chaouat, Vincent Cottin, Christophe Guignabert, Florence Coulet, Olivier Sitbon, Damien Bonnet, Marc Humbert, David Montani
BACKGROUND: Bone morphogenetic proteins 9 and 10 (BMP9 and BMP10), encoded by GDF2 and BMP10 , play a pivotal role in pulmonary vascular regulation. GDF2 variants have been reported in pulmonary arterial hypertension (PAH) and hereditary haemorrhagic telangiectasia (HHT). However, the phenotype of GDF2 and BMP10 carriers remains largely unexplored. METHODS: We report the characteristics and outcomes of PAH patients in GDF2 and BMP10 carriers from the French and Dutch PH registry...
March 21, 2024: European Respiratory Journal
https://read.qxmd.com/read/38514093/gasdermin-b-an-asthma-susceptibility-gene-promotes-mavs-tbk1-signaling-and-airway-inflammation
#4
JOURNAL ARTICLE
Tao Liu, Siqi Liu, Xianliang Rui, Ye Cao, Julian Hecker, Feng Guo, Yihan Zhang, Lu Gong, Yihan Zhou, Yuzhen Yu, Nandini Krishnamoorthyni, Samuel Bates, Sung Chun, Nathan Boyer, Shuang Xu, Jin-Ah Park, Mark A Perrella, Bruce D Levy, Scott T Weiss, Hongmei Mou, Benjamin A Raby, Xiaobo Zhou
RATIONALE: Respiratory virus-induced inflammation is the leading cause of asthma exacerbation, frequently accompanied by induction of IFN-stimulated genes (ISGs). How asthma genetic susceptible genes modulate cellular response upon viral infection through fine-tuning ISGs induction and subsequent airway inflammation in genetically susceptible asthmatics remains largely unknown. OBJECTIVES: To decipher the functions of GSDMB in respiratory virus-induced lung inflammation...
March 21, 2024: European Respiratory Journal
https://read.qxmd.com/read/38485151/the-longitudinal-microbial-and-metabolic-landscape-of-infant-cystic-fibrosis-the-gut-lung-axis
#5
JOURNAL ARTICLE
Katherine B Frayman, Matthew Macowan, Jose Caparros-Martin, Sarath C Ranganathan, Benjamin J Marsland
BACKGROUND AND AIM: : In cystic fibrosis (CF), gastrointestinal dysfunction and lower airway infection occur early and are independently associated with poorer outcomes in childhood. This study aimed to define the relationship between the microbiota at each niche during the first 2-years of life, its association with growth and airway inflammation, and explanatory features in the metabolome. MATERIALS AND METHODS: Sixty-seven bronchoalveolar lavage (BAL), 62 plasma and 105 stool samples were collected from 39 infants with CF between 0-24-months who were treated with prophylactic antibiotics...
March 14, 2024: European Respiratory Journal
https://read.qxmd.com/read/38485150/b-cells-in-pulmonary-arterial-hypertension-friend-foe-or-bystander
#6
REVIEW
Sébastien Sanges, Wen Tian, Sylvain Dubucquoi, Jason L Chang, Aurore Collet, David Launay, Mark R Nicolls
There is an unmet need for new therapeutic strategies that target alternative pathways to improve the prognosis of patients with pulmonary arterial hypertension (PAH). As immunity has been involved in the development and progression of vascular lesions in PAH, we review the potential contribution of B cells in its pathogenesis and evaluate the relevance of B cell-targeted therapies. Circulating B cell homeostasis is altered in PAH patients, with total B-cell lymphopenia, abnormal subset distribution (expansion of naïve and antibody-secreting cells, reduction of memory B cells) and chronic activation...
March 14, 2024: European Respiratory Journal
https://read.qxmd.com/read/38485149/ers-ebmt-clinical-practice-guideline-on-treatment-of-pulmonary-chronic-graft-versus-host-disease-in-adults
#7
JOURNAL ARTICLE
Saskia Bos, John Murray, Monia Marchetti, Guang-Shing Cheng, Anne Bergeron, Daniel Wolff, Clare Sander, Akshay Sharma, Sherif M Badawy, Zinaida Peric, Agnieszka Piekarska, Joseph Pidala, Kavita Raj, Olaf Penack, Samar Kulkarni, Molly Beestrum, Andrea Linke, Matthew Rutter, Courtney Coleman, Thomy Tonia, Hélène Schoemans, Daiana Stolz, Robin Vos
Chronic graft- versus -host disease (cGvHD) is a common complication after allogeneic haematopoietic stem cell transplantation, characterised by a broad disease spectrum that can affect virtually any organ. Although pulmonary cGvHD is a less common manifestation, it is of great concern due to its severity and poor prognosis. Optimal management of patients with pulmonary cGvHD is complicated and no standardised approach is available.The purpose of this joint European Respiratory Society and European Society for Blood and Marrow Transplantation Task Force was to develop evidence-based recommendations regarding the treatment of pulmonary cGvHD phenotype bronchiolitis obliterans syndrome in adults...
March 14, 2024: European Respiratory Journal
https://read.qxmd.com/read/38485148/type-2-airway-inflammation-in-chronic-obstructive-pulmonary-disease
#8
JOURNAL ARTICLE
Francesca Polverino, Don D Sin
No abstract text is available yet for this article.
March 14, 2024: European Respiratory Journal
https://read.qxmd.com/read/38485147/precision-medicine-in-cystic-fibrosis-predictive-role-of-forskolin-induced-swelling-assay
#9
LETTER
Eva Furstova, Pavel Drevinek, Stepanka Novotna, Malgorzata Libik, Klara Benesova, Lucie Borek-Dohalska, Kristina Sakmarova, Martin Modrak, Milan Macek, Tereza Dousova
No abstract text is available yet for this article.
March 14, 2024: European Respiratory Journal
https://read.qxmd.com/read/38485146/fev1q-a-race-neutral-approach-to-assessing-lung-function
#10
JOURNAL ARTICLE
Aparna Balasubramanian, Robert A Wise, Sanja Stanojevic, Martin R Miller, Meredith C McCormack
RATIONALE: FEV1Q is a simple approach to spirometry interpretation that compares measured lung function to a lower boundary. This study evaluated how well FEV1Q predicts survival compared to current interpretation methods and whether race impacts FEV1Q. METHODS: White and Black adults with complete spirometry and mortality data from the National Health and Nutrition Examination Survey (NHANES) III and United Network for Organ Sharing (UNOS) database for lung transplant referrals were included...
March 14, 2024: European Respiratory Journal
https://read.qxmd.com/read/38453259/association-between-high-levels-of-nitrogen-dioxide-and-increased-cumulative-incidence-of-lung-cancer-in-patients-with-idiopathic-pulmonary-fibrosis
#11
JOURNAL ARTICLE
Hee-Young Yoon, Sun-Young Kim, Jin Woo Song
BACKGROUND: Lung cancer is a fatal complication of idiopathic pulmonary fibrosis (IPF) with a poor prognosis. However, the association between individual exposure to air pollutants and lung cancer development in patients with IPF is unknown. This study aimed to assess the effect of individual exposure to nitrogen dioxide (NO2 ) on lung cancer development in patients with IPF. METHODS: We enrolled 1085 patients from the IPF cohort (mean age: 65.6 years, male: 80...
March 7, 2024: European Respiratory Journal
https://read.qxmd.com/read/38453258/a-proposed-approach-to-pulmonary-long-covid-a-viewpoint
#12
EDITORIAL
Firoozeh V Gerayeli, Rachel Eddy, Don D Sin
No abstract text is available yet for this article.
March 7, 2024: European Respiratory Journal
https://read.qxmd.com/read/38453257/multi-biobank-summary-data-mendelian-randomisation-does-not-support-a-causal-effect-of-il-6-signalling-on-risk-of-pulmonary-arterial-hypertension
#13
LETTER
Benjamin Woolf, James A Perry, Charles C Hong, Martin R Wilkins, Mark Toshner, Dipender Gill, Stephen Burgess, Christopher J Rhodes
No abstract text is available yet for this article.
March 7, 2024: European Respiratory Journal
https://read.qxmd.com/read/38453256/the-airway-epithelium-an-orchestrator-of-inflammation-a-key-structural-barrier-and-a-therapeutic-target-in-severe-asthma
#14
REVIEW
Richard J Russell, Louis-Philippe Boulet, Christopher E Brightling, Ian D Pavord, Celeste Porsbjerg, Del Dorscheid, Asger Sverrild
Asthma is a disease of heterogeneous pathology, typically characterized by excessive inflammatory and bronchoconstrictor responses to the environment. The clinical expression of the disease is a consequence of the interaction between environmental factors and host factors over time, including genetic susceptibility, immune dysregulation and airway remodelling. As a critical interface between the host and the environment, the airway epithelium plays an important role in maintaining homeostasis in the face of environmental challenges...
March 7, 2024: European Respiratory Journal
https://read.qxmd.com/read/38423624/revised-clinical-practice-guidelines-for-diagnosing-classifying-and-treating-allergic-bronchopulmonary-aspergillosis-mycoses-a-delphi-statement-from-the-isham-abpa-working-group
#15
JOURNAL ARTICLE
Ritesh Agarwal, Inderpaul Singh Sehgal, Valliappan Muthu, David W Denning, Arunaloke Chakrabarti, Kathirvel Soundappan, Mandeep Garg, Shivaprakash M Rudramurthy, Sahajal Dhooria, Darius Armstrong-James, Koichiro Asano, Jean-Pierre Gangneux, Sanjay H Chotirmall, Helmut J F Salzer, James D Chalmers, Cendrine Godet, Marcus Joest, Iain Page, Parameswaran Nair, P Arjun, Raja Dhar, Kana Ram Jat, Geethu Joe, Uma Maheswari Krishnaswamy, Joseph L Mathew, Venkata Nagarjuna Maturu, Anant Mohan, Alok Nath, Dharmesh Patel, Jayanthi Savio, Puneet Saxena, Rajeev Soman, Balamugesh Thangakunam, Caroline G Baxter, Felix Bongomin, William J Calhoun, Oliver A Cornely, Jo A Douglass, Chris Kosmidis, Jacques F Meis, Richard Moss, Alessandro C Pasqualotto, Danila Seidel, Rosanne Sprute, Kuruswamy Thurai Prasad, Ashutosh N Aggarwal
BACKGROUND: The ISHAM working group proposed recommendations for managing allergic bronchopulmonary aspergillosis (ABPA) nearly a decade ago. There is a need to update these recommendations due to advances in diagnostics and therapeutics. METHODS: An international expert group was convened to develop guidelines for managing ABPA (caused by Aspergillus spp.) and allergic bronchopulmonary mycosis (ABPM, fungi other than Aspergillus spp.) in adults and children using a modified Delphi method (two online rounds and one in-person meeting)...
February 29, 2024: European Respiratory Journal
https://read.qxmd.com/read/38423623/the-effect-of-high-altitude-2500%C3%A2-m-on-incremental-cycling-exercise-in-patients-with-pulmonary-arterial-hypertension-and-chronic-thromboembolic-pulmonary-hypertension-a-randomised-controlled-cross-over-trial
#16
JOURNAL ARTICLE
Julian Müller, Anna Titz, Simon R Schneider, Meret Bauer, Laura Mayer, Lea Lüönd, Tanja Ulrich, Michael Furian, Aglaia Forrer, Esther I Schwarz, Konrad E Bloch, Mona Lichtblau, Silvia Ulrich
OBJECTIVE: To investigate the effect of a daylong exposure to high altitude on peak exercise capacity and safety in stable patients with pulmonary arterial and chronic thromboembolic pulmonary hypertension (PAH/CTEPH). METHODS: In a randomised controlled cross-over trial, stable patients with PAH or distal CTEPH without resting hypoxemia at low altitude performed two incremental exercise tests to exhaustion, one after 3-5 h at high (2500 m) and one at low altitude (470 m)...
February 29, 2024: European Respiratory Journal
https://read.qxmd.com/read/38387969/long-term-radiological-and-pulmonary-function-abnormalities-at-3-year-post-covid-19-hospitalization-a-longitudinal-cohort-study
#17
JOURNAL ARTICLE
Xiaoyu Han, Lu Chen, Liyan Guo, Linxia Wu, Osamah Alwalid, Jie Liu, Yuting Zheng, Leqing Chen, Wenlong Wu, Hanting Li, Qinyue Luo, Huangxuan Zhao, Lijie Zhang, Yaowei Bai, Bo Sun, Tao Sun, Yuxi Gui, Tong Nie, Lei Chen, Fan Yang, Yanqing Fan, Heshui Shi, Chuansheng Zheng
BACKGROUND: This study aimed to evaluate the longitudinal progression of residual lung abnormalities (ground-glass opacities, reticulations, and fibrotic-like changes) and pulmonary function, three years following coronavirus disease 2019(COVID-19). METHODS: This prospective, longitudinal cohort study enrolled COVID-19 survivors who exhibited residual lung abnormalities upon discharge from two hospitals. Follow-up assessments were conducted at 6 months, 12 months, 2 years, and 3 years post-discharge, and included pulmonary function tests, 6-minute walk distance (6MWD), chest CT scans, and symptom questionnaires...
February 22, 2024: European Respiratory Journal
https://read.qxmd.com/read/38387968/neutrophil-elastase-dependent-cleavage-of-lta4h-alters-its-aminopeptidase-activity-in-cystic-fibrosis
#18
LETTER
Xin Xu, Jin-Dong Li, Todd J Green, Landon Wilson, Kristopher Genschmer, Derek Russell, J Edwin Blalock, Amit Gaggar
No abstract text is available yet for this article.
February 22, 2024: European Respiratory Journal
https://read.qxmd.com/read/38359963/repositioning-of-ezetimibe-for-the-treatment-of-idiopathic-pulmonary-fibrosis
#19
JOURNAL ARTICLE
Chanho Lee, Se Hyun Kwak, Jisu Han, Ju Hye Shin, Byunghun Yoo, Yu Seol Lee, Jeong Su Park, Beom Jin Lim, Jin Gu Lee, Young Sam Kim, Song Yee Kim, Soo Han Bae
We previously identified ezetimibe, an inhibitor of Niemann-Pick C1-like intracellular cholesterol transporter 1 and European Medicines Agency-approved lipid-lowering agent, as a potent autophagy activator. However, its efficacy against pulmonary fibrosis has not yet been evaluated. This study aimed to determine whether ezetimibe has therapeutic potential against idiopathic pulmonary fibrosis. Primary lung fibroblasts isolated from both humans and mice were employed for mechanistic in vitro experiments. mRNA sequencing of human lung fibroblasts and gene set enrichment analysis were performed to explore the therapeutic mechanism of ezetimibe...
February 22, 2024: European Respiratory Journal
https://read.qxmd.com/read/38359964/hemodynamic-phenotypes-of-pulmonary-hypertension-associated-with-left-heart-disease-a-moving-target
#20
LETTER
Christian Gerges, David Montani, Marc Humbert, Irene M Lang
No abstract text is available yet for this article.
February 15, 2024: European Respiratory Journal
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