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European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology

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https://www.readbyqxmd.com/read/28798095/the-art-of-breathing-saturation
#1
Gary P Anderson, Tom Kotsimbos
No abstract text is available yet for this article.
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28798094/immune-checkpoint-inhibitor-associated-interstitial-lung-diseases-some-progress-but-still-many-issues
#2
EDITORIAL
David Montani, Andrei Seferian, Florence Parent, Marc Humbert
No abstract text is available yet for this article.
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28798093/effects-of-sleep-apnoea-therapy-on-blood-pressure-and-metabolism-a-cpap-sex-gap
#3
EDITORIAL
Frédéric Gagnadoux, Pascaline Priou, Nicole Meslier, Wojciech Trzepizur
No abstract text is available yet for this article.
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28798092/the-shorter-multidrug-resistant-tuberculosis-treatment-regimen-in-singapore-are-patients-from-south-east%C3%A2-asia-eligible
#4
LETTER
Cynthia B E Chee, Kyi-Win KhinMar, Li-H Sng, Roland Jureen, Jeffery Cutter, Vernon J M Lee, Yee-Tang Wang
No abstract text is available yet for this article.
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28798091/longitudinal-follow-up-of-quadriceps-strength-and-function-in-a-copd-cohort-after-3-years
#5
LETTER
Sara C Buttery, Divya Mohan, Marie Fisk, Nicholas S Hopkinson, Ruth Tal-Singer, Ian B Wilkinson, Michael I Polkey
No abstract text is available yet for this article.
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28798090/egfr-tyrosine-kinase-inhibitors-versus-chemotherapy-in-egfr-wild-type-pre-treated-advanced-nonsmall-cell-lung-cancer-in%C3%A2-daily-practice
#6
Pascale Tomasini, Solenn Brosseau, Julien Mazières, Jean-Philippe Merlio, Michèle Beau-Faller, Jean Mosser, Marie Wislez, L'Houcine Ouafik, Benjamin Besse, Isabelle Rouquette, Didier Debieuvre, Fabienne Escande, Virginie Westeel, Clarisse Audigier-Valette, Pascale Missy, Alexandra Langlais, Frank Morin, Denis Moro-Sibilot, Gérard Zalcman, Fabrice Barlesi
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are approved for second-line treatment of EGFR wild-type (EGFR-wt) nonsmall cell lung cancer (NSCLC). However, results from randomised trials performed to compare EGFR-TKIs with chemotherapy in this population did not show any survival benefit. In the era of immunotherapy, many drugs are approved for second-line treatment of EGFR-wt NSCLC and there is a need to reassess the role of EGFR-TKIs in this setting.The Biomarkers France study is a large nationwide cohort of NSCLC patients tested for EGFR mutations...
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28798089/effect-of-continuous-positive-airway-pressure-on-blood-pressure-and-metabolic-profile-in-women-with-sleep-apnoea
#7
Francisco Campos-Rodriguez, Monica Gonzalez-Martinez, Angeles Sanchez-Armengol, Bernabe Jurado-Gamez, Jose Cordero-Guevara, Nuria Reyes-Nuñez, Maria F Troncoso, Araceli Abad-Fernandez, Joaquin Teran-Santos, Julian Caballero-Rodriguez, Mercedes Martin-Romero, Ana Encabo-Motiño, Lirios Sacristan-Bou, Javier Navarro-Esteva, Maria Somoza-Gonzalez, Juan F Masa, Maria A Sanchez-Quiroga, Beatriz Jara-Chinarro, Belen Orosa-Bertol, Miguel A Martinez-Garcia
Continuous positive airway pressure (CPAP) reduces blood pressure levels in hypertensive patients with obstructive sleep apnoea (OSA). However, the role of CPAP in blood pressure and the metabolic profile in women has not yet been assessed. In this study we investigated the effect of CPAP on blood pressure levels and the glucose and lipid profile in women with moderate-to-severe OSA.A multicentre, open-label, randomised controlled trial was conducted in 307 women diagnosed with moderate-to-severe OSA (apnoea-hypopnoea index ≥15 events·h(-1)) in 19 Spanish Sleep Units...
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28798088/immune-checkpoint-inhibitors-associated-with-interstitial-lung-disease-in-cancer-patients
#8
Myriam Delaunay, Jacques Cadranel, Amélie Lusque, Nicolas Meyer, Valérie Gounaut, Denis Moro-Sibilot, Jean-Marie Michot, Judith Raimbourg, Nicolas Girard, Florian Guisier, David Planchard, Anne-Cécile Metivier, Pascale Tomasini, Eric Dansin, Maurice Pérol, Marion Campana, Oliver Gautschi, Martin Früh, Jean-David Fumet, Clarisse Audigier-Valette, Sébastien Couraud, Stéphane Dalle, Marie-Thérèse Leccia, Marion Jaffro, Samia Collot, Grégoire Prévot, Julie Milia, Julien Mazieres
Immunotherapy is becoming a standard of care for many cancers. Immune-checkpoint inhibitors (ICI) can generate immune-related adverse events. Interstitial lung disease (ILD) has been identified as a rare but potentially severe event.Between December 2015 and April 2016, we conducted a retrospective study in centres experienced in ICI use. We report the main features of ICI-ILD with a focus on clinical presentation, radiological patterns and therapeutic strategies.We identified 64 (3.5%) out of 1826 cancer patients with ICI-ILD...
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28798087/epidemiology-and-impact-of-chronic-bronchitis-in-chronic-obstructive-pulmonary-disease
#9
Lies Lahousse, Leen J M Seys, Guy F Joos, Oscar H Franco, Bruno H Stricker, Guy G Brusselle
Research on the association between chronic bronchitis and chronic obstructive pulmonary disease (COPD) exacerbations has led to discordant results. Furthermore, the impact of chronic bronchitis on mortality in COPD subjects is unclear.Within the Rotterdam Study, a population-based cohort study of subjects aged ≥45 years, chronic bronchitis was defined as having a productive cough for ≥3 months per year for two consecutive years. Linear, logistic regression and Cox proportional hazard models were adjusted for age, sex and pack-years...
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28775054/licence-to-kill-senescent-cells-in-idiopathic-pulmonary-fibrosis
#10
EDITORIAL
Arnaud A Mailleux, Bruno Crestani
No abstract text is available yet for this article.
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28775053/assessing-risk-in-pulmonary-arterial-hypertension-what-we-know-what-we-don-t
#11
EDITORIAL
Raymond L Benza, Harrison W Farber, Mona Selej, Mardi Gomberg-Maitland
No abstract text is available yet for this article.
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28775052/concern-of-underdiagnosing-asthma-copd-overlap-syndrome-if-age-limit-of-40%C3%A2-years-for-asthma-is-used
#12
LETTER
Don D Sin, Janice M Leung, Michael E Wechsler
No abstract text is available yet for this article.
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28775051/inhibiting-oestrogen-signalling-in-pulmonary-arterial-hypertension-sex-drugs-and-research
#13
EDITORIAL
Tim Lahm, Steven M Kawut
No abstract text is available yet for this article.
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28775050/risk-assessment-prognosis-and-guideline-implementation-in-pulmonary-arterial-hypertension
#14
Athénaïs Boucly, Jason Weatherald, Laurent Savale, Xavier Jaïs, Vincent Cottin, Grégoire Prevot, François Picard, Pascal de Groote, Mitja Jevnikar, Emmanuel Bergot, Ari Chaouat, Céline Chabanne, Arnaud Bourdin, Florence Parent, David Montani, Gérald Simonneau, Marc Humbert, Olivier Sitbon
Current European guidelines recommend periodic risk assessment for patients with pulmonary arterial hypertension (PAH). The aim of our study was to determine the association between the number of low-risk criteria achieved within 1 year of diagnosis and long-term prognosis.Incident patients with idiopathic, heritable and drug-induced PAH between 2006 and 2016 were analysed. The number of low-risk criteria present at diagnosis and at first re-evaluation were assessed: World Health Organization (WHO)/New York Heart Association (NYHA) functional class I or II, 6-min walking distance (6MWD) >440 m, right atrial pressure <8 mmHg and cardiac index ≥2...
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28775049/concern-of-underdiagnosing-asthma-copd-overlap-syndrome-if-age-limit-of-40%C3%A2-years-for-asthma-is-used
#15
LETTER
Minna Tommola, Pinja Ilmarinen, Leena E Tuomisto, Hannu Kankaanranta
No abstract text is available yet for this article.
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28775048/modelling-future-trends-in-cystic-fibrosis-demography-using-the-french-cystic-fibrosis-registry-update-and-sensitivity-analysis
#16
LETTER
Pierre-Régis Burgel, Gil Bellis, J Stuart Elborn
No abstract text is available yet for this article.
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28775047/mortality-in-pulmonary-arterial-hypertension-prediction-by-the-2015-european-pulmonary-hypertension-guidelines-risk-stratification-model
#17
Marius M Hoeper, Tilmann Kramer, Zixuan Pan, Christina A Eichstaedt, Jens Spiesshoefer, Nicola Benjamin, Karen M Olsson, Katrin Meyer, Carmine Dario Vizza, Anton Vonk-Noordegraaf, Oliver Distler, Christian Opitz, J Simon R Gibbs, Marion Delcroix, H Ardeschir Ghofrani, Doerte Huscher, David Pittrow, Stephan Rosenkranz, Ekkehard Grünig
The 2015 European pulmonary hypertension (PH) guidelines propose a risk stratification strategy for patients with pulmonary arterial hypertension (PAH). Low-, intermediate- and high-risk strata are defined by estimated 1-year mortality risks of <5%, 5-10% and >10%, respectively. This risk assessment strategy awaits validation.We analysed data from patients with newly diagnosed PAH enrolled into COMPERA (Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension), a European-based PH registry...
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28775046/more-on-idiopathic-pulmonary-arterial-hypertension-with-a-low-diffusing-capacity
#18
LETTER
Karen M Olsson, Jan Fuge, Katrin Meyer, Tobias Welte, Marius M Hoeper
No abstract text is available yet for this article.
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28775045/prevalence-and-incidence-of-interstitial-lung-diseases-in-a-multi-ethnic-county-of-greater-paris
#19
Boris Duchemann, Isabella Annesi-Maesano, Camille Jacobe de Naurois, Shreosi Sanyal, Pierre-Yves Brillet, Michel Brauner, Marianne Kambouchner, Sophie Huynh, Jean Marc Naccache, Raphael Borie, Jacques Piquet, Arsène Mekinian, Jerôme Virally, Yurdagul Uzunhan, Jacques Cadranel, Bruno Crestani, Olivier Fain, Francois Lhote, Robin Dhote, Nathalie Saidenberg-Kermanac'h, Paul-André Rosental, Dominique Valeyre, Hilario Nunes
The objective of the study was to estimate the prevalence and incidence of interstitial lung diseases (ILDs) in Seine-Saint-Denis, a multi-ethnic county of Greater Paris, France.Patients with ILDs were identified between January and December 2012 by using several sources; all potentially involved medical specialists from public and private hospitals, community-based pulmonologists and general practitioners, and the Social Security system. Diagnoses were validated centrally by an expert multidisciplinary discussion...
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28775044/senolytic-drugs-target%C3%A2-alveolar-epithelial-cell-function-and-attenuate-experimental-lung-fibrosis-ex-vivo
#20
Mareike Lehmann, Martina Korfei, Kathrin Mutze, Stephan Klee, Wioletta Skronska-Wasek, Hani N Alsafadi, Chiharu Ota, Rita Costa, Herbert B Schiller, Michael Lindner, Darcy E Wagner, Andreas Günther, Melanie Königshoff
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with poor prognosis and limited therapeutic options. The incidence of IPF increases with age, and ageing-related mechanisms such as cellular senescence have been proposed as pathogenic drivers. The lung alveolar epithelium represents a major site of tissue injury in IPF and senescence of this cell population is probably detrimental to lung repair. However, the potential pathomechanisms of alveolar epithelial cell senescence and the impact of senolytic drugs on senescent lung cells and fibrosis remain unknown...
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
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