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European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology

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https://www.readbyqxmd.com/read/30002106/is-chronic-breathlessness-less-recognized-and-treated-compared-with-chronic-pain-a-case-based-randomised-controlled-trial
#1
LETTER
Zainab Ahmadi, Jacob Sandberg, Aaron Shannon-Honson, Zac Vandersman, David C Currow, Magnus Ekström
No abstract text is available yet for this article.
July 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30002105/recurrence-rates-in-primary-spontaneous-pneumothorax-a-systematic-review-and-meta-analysis
#2
Steven Walker, Anna Bibby, Paul Halford, Louise Stadon, Paul White, Nick Maskell
Primary Spontaneous Pneumothorax (PSP) recurrence rates vary widely in the published literature, with limited data describing the factors that influence recurrence. The aims of this systematic review were to determine an estimation of PSP recurrence rates and describe risk factors for recurrence.A systematic review was conducted of all studies reporting PSP recurrence. Electronic searches were performed to identify English language publications of randomised trials and observational studies. The population was adults with PSP, who underwent conservative management, pleural aspiration or chest drainage...
July 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30002104/lung-function-trajectories-using-different-reference-equations-in-a-birth-cohort-study-up-to-the-age-of-20-years
#3
LETTER
Christiane Lex, Marvin Reuter, Antje Schuster, Linus Grabenhenrich, Carl-Peter Bauer, Ute Hoffmann, Johannes Forster, Fred Zepp, Ulrich Wahn, Thomas Keil, Susanne Lau, Dirk Schramm
No abstract text is available yet for this article.
July 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30002103/a-systematic-review-on-how-patients-value-chronic-obstructive-pulmonary-disease-outcomes
#4
Yuan Zhang, Rebecca L Morgan, Pablo Alonso-Coello, Wojtek Wiercioch, Małgorzata M Bała, Rafał R Jaeschke, Krzysztof Styczeń, Hector Pardo-Hernandez, Anna Selva, Housne Ara Begum, Gian Paolo Morgano, Marcin Waligóra, Arnav Agarwal, Matthew Ventresca, Karolina Strzebońska, Mateusz T Wasylewski, Lídia Blanco-Silvente, Janna-Lina Kerth, Mengxiao Wang, Yuqing Zhang, Saiprasad Narsingam, Yutong Fei, Gordon Guyatt, Holger J Schünemann
Our objective was to systematically summarize all research evidence related to how patients value outcomes in chronic obstructive pulmonary disease (COPD).We conducted a systematic review (Systematic review registration: CRD42015015206) by searching PubMed, Embase, PsycInfo, and CINAHL, and included reports that assessed the relative importance of outcomes from COPD patients' perspective. Two authors independently determined the eligibility of studies, abstracted the eligible studies and assessed risk of bias...
July 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30002102/the-impact-of-patient-choice-on-survival-in-chronic-thromboembolic-pulmonary-hypertension
#5
S R Quadery, A J Swift, C Billings, Aar Thompson, C A Elliot, J Hurdman, A Charalampopoulos, I Sabroe, I Armstrong, N Hamilton, P Sephton, S Garrod, J Pepke-Zaba, D P Jenkins, N Screaton, A M Rothman, A Lawrie, T Cleveland, S Thomas, S Rajaram, C Hill, C Davies, C S Johns, J M Wild, R Condliffe, D G Kiely
BACKGROUND: Pulmonary endarterectomy (PEA) is the gold standard treatment for operable chronic thromboembolic pulmonary hypertension (CTEPH). However, a proportion of patients with operable disease decline surgery. There are currently no published data on this patient group. The aim of this study was to identify outcomes and prognostic factors in a large cohort of consecutive patients with CTEPH. METHODS: Data were collected for consecutive, treatment-naïve CTEPH patients between 2001-2014 identified from the ASPIRE registry...
July 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29976656/macitentan-reduces-progression-of-tgf-%C3%AE-1-induced-pulmonary-fibrosis-and-pulmonary-hypertension
#6
Pierre-Simon Bellaye, Toyoshi Yanagihara, Elise Granton, Seidai Sato, Chiko Shimbori, Chandak Upagupta, Jewel Imani, Nathan Hambly, Kjetil Ask, Jack Gauldie, Marc Iglarz, Martin Kolb
No abstract text is available yet for this article.
July 5, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29976655/rhinovirus-rv-is-the-most-common-virus-and-rv-c-the-most-common-rv-species-in-paediatric-intensive-care-respiratory-admissions
#7
LETTER
Desmond W Cox, Siew-Kim Khoo, Guicheng Zhang, Katie Lindsay, Anthony D Keil, Geoff Knight, Jim E Gern, Ingrid A Laing, Joelene Bizzintino, Peter N Le Souëf
Respiratory virus infections account for a significant proportion of acute admissions to the paediatric intensive care unit (PICU). Recent studies have shown that rhinoviruses (RV) are the most frequent virus detected in severe cases of acute respiratory illnesses (ARI) admitted to a PICU. The aim of this study was to determine the prevalence of different viruses, in particular RV species, in children with ARI admitted to a tertiary PICU. Nasopharyngeal aspirates (NPA) from 229 children admitted to PICU with an ARI were analysed...
July 5, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29976654/role-of-c1q-binding-anti-hla-antibodies-as-a-predictor-of-lung-allograft-outcome
#8
O Brugière, A Roux, J Le Pavec, D Sroussi, F Parquin, P Pradère, C Dupin, V Bunel, G Mourin, G Jebrak, G Dauriat, Y Castier, P Mordant, B Lortat-Jacob, S Jean-Baptiste, H Mal, C Suberbielle, C Gautreau, S Caillat-Zucman, A Cazes, G Thabut, J L Taupin
Rationale : Presence of anti-HLA donor-specific antibodies (DSAs) is associated with poor outcome after lung transplantation (LTx). DSAs are currently detected by Luminex technique, which may be overly sensitive. The new C1q assay allows for the exclusive detection of complement (C1q)-binding antibodies, involved in antibody-mediated rejection. Objectives: To investigate whether early detection of complement-binding DSAs is associated with chronic lung allograft dysfunction (CLAD) and survival. Methods: From 2009-2012, LTx recipients from 3 transplantation centers were screened for the presence of DSA and their complement-binding capacity during the 6-12 months post-transplantation in stable condition...
July 5, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29976653/rem-associated-sleep-apnoea-prevalence-and-clinical-significance-in-the-hypnolaus-cohort
#9
Patricia Acosta-Castro, Camila Hirotsu, Helena Marti-Soler, Pedro Marques-Vidal, Nadia Tobback, Daniela Andries, Gérard Waeber, Martin Preisig, Peter Vollenweider, José Haba-Rubio, Raphael Heinzer
Study Objectives: This study determined the prevalence of rapid eye movement-related sleep-disordered breathing (REM-SDB) in the general population, and investigated the associations of REM-SDB with hypertension, metabolic syndrome, diabetes and depression. Methods: 2074 home polysomnography (PSG) recordings from the population-based HypnoLaus Sleep Cohort (48.3% men, 57±11 years old) were analysed. The apnoea-hypopnoea index was measured during REM (REM-AHI) and non-REM (NREM-AHI) sleep. Regression models were used to explore the association between REM-SDB and hypertension, diabetes, metabolic syndrome and depression in the entire cohort and in subgroups with NREM-AHI<10/h and total AHI<10/h...
July 5, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29976652/pharmacists-and-medication-adherence-in-asthma-a-systematic-review-and-meta-analysis
#10
REVIEW
Marissa Ayano Mes, Caroline Brigitte Katzer, Amy Hai Yan Chan, Vari Wileman, Stephanie Jane Caroline Taylor, Rob Horne
The Lancet Asthma Commission highlighted that non-adherence remains a persistent barrier within asthma care. Medical consultations remain pivotal in addressing non-adherence, but interest in additional adherence support from pharmacists is increasing. This systematic review and meta-analysis aims to evaluate how effective pharmacist-led interventions are in improving medication adherence in adults with asthma.Studies were included if they had adult participants with asthma, pharmacist-led or collaborative care interventions, randomised controlled trial (RCT) designs comparing interventions with usual pharmacist care, and a medication adherence outcome...
July 5, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29976651/burden-and-risk-factors-for-pseudomonas-aeruginosa-community-acquired-pneumonia-a-multinational-point-prevalence-study-of-hospitalised-patients
#11
Marcos I Restrepo, Bettina L Babu, Luis F Reyes, James D Chalmers, Nilam J Soni, Oriol Sibila, Paola Faverio, Catia Cilloniz, William Rodriguez-Cintron, Stefano Aliberti
Pseudomonas aeruginosa is a challenging bacterium to treat due to its intrinsic antibiotic resistance to the most frequently used antibiotics in patients with community-acquired pneumonia (CAP). Data about the global burden and risk factors associated with P. aeruginosa -CAP are limited. We assessed the multinational burden and specific risk factors associated with P. aeruginosa- CAP.We enrolled 3,193 patients in 54 countries with confirmed diagnosis of CAP that underwent microbiological testing at admission...
July 5, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29976650/dyspnea-in-patients-receiving-noninvasive-ventilation-for-acute-respiratory-failure-prevalence-risk-factors-and-prognostic-impact-a-prospective-observational-study
#12
Laurence Dangers, Claire Montlahuc, Achille Kouatchet, Samir Jaber, Ferhat Meziani, Sébastien Perbet, Thomas Similowski, Matthieu Resche-Rigon, Elie Azoulay, Alexandre Demoule
Dyspnea is a frequent and intense symptom in intubated patients, but little attention has been paid to dyspnea during noninvasive mechanical ventilation (NIV) in the intensive care unit (ICU).The objectives of this study were to quantify the prevalence, intensity and prognostic impact of dyspnea in patients receiving NIV for acute respiratory failure (ARF) based on secondary analysis of a prospective observational cohort study in patients who received ventilatory support for ARF in 54 ICUs in France and Belgium...
July 5, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29976649/non-adherence-with-inhaled-preventer-therapy-in-severe-asthmatic-patients-on-long-term-omalizumab
#13
LETTER
D J Allen, L J Holmes, K A Hince, R Daly, C Ustabashi, G Tavernier
No abstract text is available yet for this article.
July 5, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29976648/effects-of-1-month-of-zopiclone-on-osa-severity-symptoms-a-randomised-controlled-trial
#14
Sophie G Carter, Jayne C Carberry, Garry Cho, Lauren P Fisher, Charlotte M Rollo, David J Stevens, Angela L D'Rozario, David K McKenzie, Ronald R Grunstein, Danny J Eckert
Hypnotic use in obstructive sleep apnoea (OSA) is contraindicated due to safety concerns. Recent studies indicate that single-night hypnotic use worsens hypoxaemia in some and reduces OSA severity in others depending on differences in pathophysiology. However, longer clinical trial data is lacking. This study aimed to determine the effects of 1-month of zopiclone on OSA severity, sleepiness and alertness in patients with low-moderate respiratory arousal thresholds without major overnight hypoxaemia.69 participants completed a physiology screening night with an epiglottic catheter to quantify arousal threshold...
July 5, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29946010/familial-aggregation-and-heritability-of-sarcoidosis-a-swedish-nested-case-control-study
#15
Marios Rossides, Johan Grunewald, Anders Eklund, Susanna Kullberg, Daniela Di Giuseppe, Johan Askling, Elizabeth V Arkema
Sarcoidosis is believed to be caused by both genetic and environmental risk factors, but the proportion of the susceptibility to sarcoidosis which is mediated by genetics remains unknown. We aimed to estimate the familial aggregation and heritability of sarcoidosis using a case-control-family study design and population-based Swedish registers.We identified 23 880 individuals with visits for sarcoidosis in the National Patient Register using ICD codes (1964‒2013). Information Löfgren's syndrome was available for a subset diagnosed at Karolinska University Hospital...
June 25, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29946009/impaired-efferocytosis-and-neutrophil-extracellular-traps-clearance-by-macrophages-in-ards
#16
Murielle Grégoire, Fabrice Uhel, Mathieu Lesouhaitier, Arnaud Gacouin, Marion Guirriec, Frederic Mourcin, Erwan Dumontet, Arnaud Chalin, Michel Samson, Laure-Line Berthelot, Adrien Tissot, Mallorie Kerjouan, Stéphane Jouneau, Yves Le Tulzo, Karin Tarte, Jaroslaw W Zmijewski, Jean-Marc Tadié
Rationale Exaggerated release of neutrophil extracellular traps (NET) along with decreased NET clearance and inability to remove apoptotic cells (efferocytosis) may contribute to sustained inflammation in Acute respiratory distress syndrome (ARDS). Recent studies in experimental models of ARDS have revealed the crosstalk between AMPK and HMGB1 which may contribute to effectiveness of efferocytosis, therefore reducing inflammation and ARDS severity. Methods We investigated neutrophil and NET clearance by macrophages from control and ARDS patients and examined how bronchoalveolar lavage (BAL) fluids from control and ARDS patients could affect NET formation and efferocytosis...
June 25, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29946008/prevalence-characteristics-and-management-of-frequently-exacerbating-asthma-patients-an-observational-study-in-sweden-pacehr
#17
Christer Janson, Karin Lisspers, Björn Ställberg, Gunnar Johansson, Marcus Thuresson, Gunilla Telg, Kjell Larsson
AIM: To investigate prevalence, management and characteristics of asthma patients with frequent exacerbations. METHOD: Data from asthma patients (≥18 years) identified in primary care medical records were linked to national Swedish health registries. Exacerbations defined as hospitalisations, emergency visits and/or collection of oral steroids. Frequent exacerbations defined as ≥2 exacerbations/year during the 3-year observation period. RESULTS: Of 18 724 asthma patients, 81...
June 25, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29946007/stability-or-improvement-in-forced-vital-capacity-with-nintedanib-in-patients-with-ipf
#18
Kevin R Flaherty, Martin Kolb, Carlo Vancheri, Wenbo Tang, Craig S Conoscenti, Luca Richeldi
In the Phase III INPULSIS® trials, nintedanib reduced the annual rate of decline in forced vital capacity (FVC) versus placebo in patients with IPF.We conducted post-hoc analyses of the distribution of changes in FVC in the INPULSIS® trials and FVC changes in the open-label extension trial INPULSIS®-ON in subgroups of patients based on whether patients had shown an improvement/no decline in FVC in INPULSIS®. Analyses were descriptive.Based on annual rate of change in FVC, 158 of 638 patients (24.8%) treated with nintedanib and 38 of 423 patients (9...
June 25, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29946006/serotonergic-antidepressant-use-and-morbidity-and-mortality-among-older-adults-with-copd
#19
Nicholas T Vozoris, Xuesong Wang, Peter C Austin, Anne L Stephenson, Denis E O'Donnell, Andrea S Gershon, Sudeep S Gill, Paula A Rochon
We evaluated the relationship between new selective serotonin reuptake inhibitor (SSRI) or serotonin norepinephrine reuptake inhibitor (SNRI) drug use and respiratory-related morbidity and mortality among older adults with chronic obstructive pulmonary disease (COPD).This was retrospective, population-based, cohort study using Ontario, Canada, heath administrative data. Individuals ages 66 years of age and older, with validated, physician-diagnosed COPD (n=131,718) were included. New SSRI/SNRI users were propensity score matched 1:1 to controls on 40 relevant covariates to minimize potential confounding...
June 25, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29946005/safety-of-nintedanib-added-to-pirfenidone-treatment-for-idiopathic-pulmonary-fibrosis
#20
Kevin R Flaherty, Charlene D Fell, J Terrill Huggins, Hilario Nunes, Robert Sussman, Claudia Valenzuela, Ute Petzinger, John L Stauffer, Frank Gilberg, Monica Bengus, Marlies Wijsenbeek
We assessed safety and tolerability of treatment with pirfenidone (1602-2403 mg/day) and nintedanib (200-300 mg/day) in patients with idiopathic pulmonary fibrosis (IPF).This 24-week, single-arm, open-label Phase IV study (NCT02598193) enrolled patients with IPF with forced vital capacity (FVC) ≥50% and carbon monoxide diffusing capacity (DLco) ≥30%. Before initiating nintedanib, patients had received pirfenidone for ≥16 weeks and tolerated a stable dose of ≥1602 mg/day for ≥28 days. The primary endpoint was proportion of patients who completed 24 weeks of combination treatment on pirfenidone (1602-2403 mg/day) and nintedanib (200-300 mg/day)...
June 25, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
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