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European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology

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https://www.readbyqxmd.com/read/30237306/what-is-a-copd-exacerbation-current-definitions-pitfalls-challenges-and-opportunities-for-improvement
#1
Victor Kim, Shawn D Aaron
Chronic Obstructive Pulmonary Disease (COPD) is a chronic illness that may be periodically punctuated by exacerbations, characterised by acute worsening of dyspnea, and/or cough and sputum production, and/or increased sputum purulence. COPD exacerbations are common and carry with them important clinical and economic consequences including lost work productivity, increased utilisation of health care resources, temporary or permanent reductions in lung function and exercise capacity, hospitalisation, and sometimes death...
September 20, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30237305/safety-of-biweekly-alpha1-antitrypsin-treatment-in-the-rapid-program
#2
LETTER
Timm Greulich, Jan Chlumsky, Marion Wencker, Oliver Vit, Michael Fries, Thomas Chung, Amgad Shebl, Claus Vogelmeier, Kenneth R Chapman, Noel G McElvaney
No abstract text is available yet for this article.
September 20, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30209200/european-union-standard-for-tuberculosis-care-on-treatment-of-multidrug-resistant-tuberculosis-following-publication-of-the-new-world-health-organization-recommendations
#3
LETTER
Giovanni Battista Migliori, Giovanni Sotgiu, Senia Rosales-Klintz, Marieke J van der Werf
No abstract text is available yet for this article.
September 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30209199/the-mechanical-ventilation-respiratory-distress-observation-scale-mv-rdos-as-a-surrogate-of-self-reported-dyspnea-in-intubated-patients
#4
LETTER
Maxens Decavèle, Frédérick Gay, Romain Persichini, Julien Mayaux, Capucine Morélot-Panzini, Thomas Similowski, Alexandre Demoule
No abstract text is available yet for this article.
September 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30209198/whole-genome-sequencing-of-mycobacterium-tuberculosis
#5
Andrea M Cabibbe, Timothy M Walker, Stefan Niemann, Daniela M Cirillo
Next Generation Sequencing (NGS) technologies using massively parallel processing to interrogate pathogen genomes in days are revolutionising the clinical microbiology practice [1]. Whole genome sequencing (WGS) offers unprecedented resolution for genotyping, outbreak investigation and determination of known sequence variants involved in antimicrobial resistance (AMR), which deep sequencing of selected genomic regions (targeted NGS, tNGS) can further illuminate. WGS-based approach has been proposed for surveillance of bacterial pathogens included in the "priority list" by the World Health Organization (WHO) [2]...
September 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30209197/systemic-oxidative-stress-in-the-congenital-central-hypoventilation-syndrome
#6
LETTER
Donatella Degl'Innocenti, Matteo Becatti, Marta Peruzzi, Claudia Fiorillo, Matteo Ramazzotti, Niccolò Nassi, Cinzia Arzilli, Raffaele Piumelli
No abstract text is available yet for this article.
September 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30209196/haemodynamics-and-serial-risk-assessment-in-systemic-sclerosis-associated-pulmonary-arterial-hypertension
#7
Jason Weatherald, Athénaïs Boucly, David Launay, Vincent Cottin, Grégoire Prévot, Delphine Bourlier, Claire Dauphin, Ari Chaouat, Laurent Savale, Xavier Jaïs, Mitja Jevnikar, Julie Traclet, Pascal De Groote, Gérald Simonneau, Eric Hachulla, Luc Mouthon, David Montani, Marc Humbert, Olivier Sitbon
The prognostic importance of follow-up haemodynamics and the validity of multidimensional risk assessment are not well established for systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH).We assessed incident SSc-PAH patients to determine the association between clinical and haemodynamic variables at baseline and first follow-up right heart catheterization (RHC) with transplant-free survival. RHC variables included cardiac index (CI), stroke volume index (SVI), pulmonary arterial compliance (PCa) and pulmonary vascular resistance (PVR)...
September 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30209195/inhaled-corticosteroid-containing-combinations-and-mortality-in-copd
#8
LETTER
Jørgen Vestbo, Leonardo Fabbri, Alberto Papi, Stefano Petruzzelli, Mario Scuri, Alessandro Guasconi, Stefano Vezzoli, Dave Singh
No abstract text is available yet for this article.
September 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30209194/does-early-onset-asthma-increase-childhood-obesity-risk-a-pooled-analysis-of-16-european-cohorts
#9
Zuelma A Contreras, Zhanghua Chen, Theano Roumeliotaki, Isabella Annesi-Maesano, Nour Baïz, Andrea von Berg, Anna Bergström, Sarah Crozier, Liesbeth Duijts, Sandra Ekström, Esben Eller, Maria P Fantini, Henrik Fomsgaard Kjaer, Francesco Forastiere, Beatrix Gerhard, Davide Gori, Margreet W Harskamp-van Ginkel, Joachim Heinrich, Carmen Iñiguez, Hazel Inskip, Thomas Keil, Manolis Kogevinas, Susanne Lau, Irina Lehmann, Dieter Maier, Evelien R van Meel, Monique Mommers, Mario Murcia, Daniela Porta, Henriëtte A Smit, Marie Standl, Nikos Stratakis, Jordi Sunyer, Carel Thijs, Maties Torrent, Tanja Gm Vrijkotte, Alet H Wijga, Kiros Berhane, Frank Gilliland, Leda Chatzi
The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. We examined whether early-onset asthma and related phenotypes are associated with the risk of developing obesity in childhood.This study includes 21 130 children born from 1990 to 2008 in Denmark, France, Germany, Greece, Italy, the Netherlands, Spain, Sweden, and United Kingdom . We followed non-obese children at 3-4 years of age for incident obesity up to 8 years of age...
September 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30190274/consequences-of-long-term-ocs-therapy-and-its-side-effects-in-severe-asthma-in-adults-a-focused-review-of-the-impact-data-in-the-literature
#10
REVIEW
Timm Volmer, Timo Effenberger, Christoph Trautner, Roland Buhl
This review provides an overview of the role of long-term treatment of severe asthma with oral corticosteroids (OCS) and its associated side effects in adults. It is based on a systematic literature search conducted in MEDLINE, EMBASE, and the Cochrane Library to identify relevant studies. After a short overview of severe asthma and its treatment we present studies showing a dose-response relationship in asthmatic patients treated with OCS and then consider by organ systems the undesired effects demonstrated in clinical and epidemiological studies in patients with OCS-dependent asthma...
September 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30139777/air-pollution-exposure-and-lung-function-until-age-16-the-piama-birth-cohort-study
#11
Edith B Milanzi, Gerard H Koppelman, Henriette A Smit, Alet H Wijga, Marieke Oldenwening, Judith M Vonk, Bert Brunekreef, Ulrike Gehring
Evidence for effects of air pollution exposure on lung function growth into adolescence is scarce. We investigated associations of air pollution exposure with lung function and lung function growth until age 16.We conducted longitudinal (N=915) and cross-sectional analyses (N=721) of associations of air pollution exposure with forced expiratory volume in 1 s (FEV1 ) and forced vital capacity (FVC) growth from ages 8 to 16 and FEV1 and FVC at age 16. We estimated residential concentrations of nitrogen dioxide (NO2 ), "soot", and particulate matter with diameters <2...
September 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30190275/pulmonary-function-testing-is-safe-in-patients-with-thoracic-aortic-aneurysms
#12
LETTER
Freddy Frost, Rob Peat, Joan McWean, Matt Shaw, Mark Field, Dilip Nazareth, Martin Walshaw
No abstract text is available yet for this article.
September 6, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30190273/myeloperoxidase-oxidation-of-methionine-associates-with-early-cystic-fibrosis-lung-disease
#13
Joshua D Chandler, Camilla Margaroli, Hamed Horati, Matthew B Kilgore, Mieke Veltman, H Ken Liu, Alexander J Taurone, Limin Peng, Lokesh Guglani, Karan Uppal, Young-Mi Go, Harm A W M Tiddens, Bob J Scholte, Rabindra Tirouvanziam, Dean P Jones, Hettie M Janssens
Rationale: Cystic fibrosis (CF) lung disease progressively worsens from infancy to adulthood. Disease-driven changes in early CF airway fluid metabolites may identify therapeutic targets to curb progression. Methods: CF patients aged 12-38 months (n=24; 3/24 later denoted as CF screen positive, inconclusive diagnosis) received chest computed tomography scans, scored by the PRAGMA-CF method to quantify total lung damage (PRAGMA-%Dis) and components such as bronchiectasis. Small molecules in bronchoalveolar lavage fluid (BALF) were measured with high-resolution, accurate-mass metabolomics...
September 6, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30190272/the-dna-repair-transcriptome-in-severe-copd
#14
Maor Sauler, Maxime Lamontagne, Eric Finnemore, Jose D Herazo-Maya, John Tedrow, Xuchen Zhang, Julia E Morneau, Frank Sciurba, Wim Timens, Peter D Paré, Patty J Lee, Naftali Kaminski, Yohan Bossé, Jose L Gomez
BACKGROUND: Inadequate DNA repair is implicated in the pathogenesis of COPD. However, the mechanisms that underlie inadequate DNA repair in COPD are poorly understood. OBJECTIVES: We applied an integrative genomic approach to identify DNA repair genes and pathways associated with COPD severity. METHODS: We measured the transcriptomic changes of 419 genes involved in DNA repair and DNA damage tolerance that occur with severe COPD in three independent cohorts (n=1129). Differentially expressed genes were confirmed with RNA sequencing and used for patient clustering...
September 6, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30190271/the-one-airway-one-disease-concept-in-light-of-th2-inflammation
#15
Lisa Giovannini-Chami, Agnès Paquet, Céline Sanfiorenzo, Nicolas Pons, Julie Cazareth, Virginie Magnone, Kévin Lebrigand, Benoit Chevalier, Ambre Vallauri, Valérie Julia, Charles-Hugo Marquette, Brice Marcet, Sylvie Leroy, Pascal Barbry
In line with the pathophysiological continuum described between nose and bronchus in allergic respiratory diseases, we assessed whether nasal epithelium could mirror the Th2 status of bronchial epithelium.Nasal and bronchial cells were collected by brushings from patients with allergic rhinitis and asthma (AR, n=12), isolated allergic rhinitis (R, n=14) and healthy controls (C, n=13). Cellular composition was assessed by flow cytometry. Gene expression was analysed by RNA sequencing. Th2, Th17 and interferon signatures were derived from the literature...
September 6, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30190270/detection-of-mild-cognitive-impairment-in-middle-aged-and-older-adults-with-obstructive-sleep-apnea
#16
Katia Gagnon, Andrée-Ann Baril, Jacques Montplaisir, Julie Carrier, Sirin Chami, Serge Gauthier, Chantal Lafond, Jean-François Gagnon, Nadia Gosselin
Obstructive sleep apnea increases the risk for mild cognitive impairment and dementia. The present study aimed at characterising the ability of two cognitive screening tests, the Mini-Mental State Examination and Montreal Cognitive Assessment, to detect mild cognitive impairment in adults aged 55 to 85 years with versus without obstructive sleep apnea.We included 42 subjects with mild and 67 subjects with moderate to severe obstructive sleep apnea. We compared them to 22 control subjects. Mild cognitive impairment was diagnosed with a comprehensive neuropsychological assessment...
September 6, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30190269/inhaled-corticosteroids-in-copd-friend-or-foe
#17
REVIEW
Alvar Agusti, Leonardo M Fabbri, Dave Singh, Jørgen Vestbo, Bartolome Celli, Frits Me Franssen, Klaus F Rabe, Alberto Papi
The efficacy, safety and positioning of inhaled corticosteroids (ICS) in the treatment of patients with chronic obstructive pulmonary disease (COPD) is much debated, since it can result in clear clinical benefits in some patients ("friend") but can be ineffective or even associated with undesired side effects, e.g. pneumonia, in others ("foe"). After critically reviewing the evidence for and against ICS treatment in patients with COPD, we propose that: 1) ICS should not be used as a single, stand-alone therapy in COPD; 2) patients most likely to benefit from the addition of ICS to long-acting bronchodilators include those with history of multiple or severe exacerbations despite appropriate maintenance bronchodilator use, particularly if blood eosinophils are >300 cells·µL-1 , and those with a history of and/or concomitant asthma; and 3) the risk of pneumonia in COPD patients using ICS is higher in those with older age, lower body mass index, greater overall fragility, receiving higher ICS doses and those with blood eosinophils <100 cells·µL-1 All these factors must be carefully considered and balanced in any individual COPD patient before adding ICS to her/his maintenance bronchodilator treatment...
September 6, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30190268/splunc1-degradation-by-the-cystic-fibrosis-mucosal-environment-drives-airway-surface-liquid-dehydration
#18
Megan J Webster, Boris Reidel, Chong D Tan, Arunava Ghosh, Neil E Alexis, Scott H Donaldson, Mehmet Kesimer, Carla M P Ribeiro, Robert Tarran
Mutations in the cystic fibrosis transmembrane regulator ( CFTR ) gene, which lead to diminished transepithelial anion transport, cause the multi-organ disease cystic fibrosis (CF). CF lungs are characterised by airway surface liquid (ASL) dehydration, chronic infection/inflammation and neutrophilia. Dysfunctional CFTR may up-regulate the epithelial Na+ channel (ENaC), further exacerbating dehydration. We previously demonstrated that the short palate lung and nasal epithelial clone 1 (SPLUNC1) negatively regulates ENaC in normal airway epithelia...
September 6, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30166326/the-short-term-bronchodilator-effects-of-the-dual-pde3-and-pde4-inhibitor-rpl554-in-copd
#19
Dave Singh, Katharine Abbott-Banner, Thomas Bengtsson, Kenneth Newman
Introduction: We investigated the short term bronchodilator effects of RPL554 (an inhaled dual phosphodiesterase 3 and 4 inhibitor) combined with other bronchodilators in COPD patients with reversibility (>150 mL to short acting bronchodilators). Methods: Study 1: six way placebo controlled crossover study (n=36) with single doses of RPL554 (6 mg), salbutamol (200 µg), ipratropium (40 µg), RPL554+salbutamol, RPL554+ipratropium and placebo. Study 2: three way crossover study (n=30) of tiotropium (18 µg) combined with RPL554 (1...
August 30, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30166325/evaluating-the-potential-costs-and-impact-of-digital-health-technologies-for-tuberculosis-treatment-support
#20
Ntwali Placide Nsengiyumva, Benjamin Mappin-Kasirer, Olivia Oxlade, Mayara Bastos, Anete Trajman, Dennis Falzon, Kevin Schwartzman
Ensuring adherence and support during treatment of tuberculosis (TB) is a major public health challenge. Digital health technologies could help improve treatment outcomes. We considered their potential cost and impact on treatment for active or latent TB in Brazil.Decision analysis models simulated two adult cohorts with 1) drug-susceptible active TB, and 2) multidrug-resistant TB; and two cohorts treated with isoniazid for latent TB infection (LTBI): 1) close contacts of persons with active TB, and 2) others newly diagnosed with LTBI...
August 30, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
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