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European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology

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https://www.readbyqxmd.com/read/29773692/reduced-neural-gating-of-respiratory-sensations-is-associated-with-increased-dyspnoea-perception
#1
LETTER
Michaela Herzog, Josef Sucec, Ilse Van Diest, Omer Van den Bergh, Pei-Ying Sarah Chan, Paul Davenport, Andreas von Leupoldt
No abstract text is available yet for this article.
May 17, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29773691/prognostic-value-of-cardiovascular-parameters-in-ct-pulmonary-angiography-in-patients-with-acute-pulmonary-embolism
#2
Ludo F M Beenen, Patrick Bossuyt, Jaap Stoker, Saskia Middeldorp
No abstract text is available yet for this article.
May 17, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29773690/prevalence-and-impact-of-who-group-3-pulmonary-hypertension-in-advanced-idiopathic-nonspecific-interstitial-pneumonia
#3
LETTER
Christopher S King, A Whitney Brown, Oksana A Shlobin, Nargues Weir, Matthew Libre, Domingo Franco-Palacios, Shahzad Ahmad, Steven D Nathan
No abstract text is available yet for this article.
May 17, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29773689/risk-factors-for-lung-disease-progression-in-children-with-cystic-fibrosis
#4
Marieke van Horck, Kim van de Kant, Bjorn Winkens, Geertjan Wesseling, Vincent Gulmans, Han Hendriks, Chris van der Grinten, Quirijn Jӧbsis, Edward Dompeling
To identify potential risk factors for lung disease progression in children with cystic fibrosis (CF), we studied the longitudinal data of all children with CF (aged ≥5 years) registered in the Dutch CF Registry (2009-2014). Lung disease progression was expressed as a decline in lung function (FEV1 %pred) and the pulmonary exacerbation rate (PEx). Potential risk factors at baseline included: sex, age, best FEV1%pred, best forced vital capacity (FVC)%pred, genotype, BMI z-score, pancreatic insufficiency, medication use (proton pump inhibitors [PPI], prophylactic antibiotics, and inhaled corticosteroids), CF-related diabetes, allergic bronchopulmonary aspergillosis, and colonisation with Pseudomonas aeruginosa The data of 545 children were analysed...
May 17, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29773688/understanding-patients-perceptions-of-asthma-control-a-qualitative-study
#5
Natalie Bidad, Neil Barnes, Chris Griffiths, Rob Horne
Asthma control is suboptimal for many sufferers despite the existence of effective treatments. Patients' self-management is influenced by their perceptions of asthma and its treatment. This study explored sufferers' perceptions of asthma control and their influence on self-management behaviours.Participants (n=42) recruited from primary and secondary care asthma clinics in London each underwent a qualitative interview exploring perceptions and experiences of asthma control. Purposive sampling ensured variation in disease severity, degree of asthma control, age and socioeconomic status...
May 17, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29748310/do-laboratory-challenge-tests-for-occupational-asthma-represent-what-happens-in-the-workplace
#6
P Sherwood Burge, Vicky C Moore, Alastair S Robertson, Gareth I Walters
INTRODUCTION: Specific inhalation challenge (SIC) is the diagnostic reference standard for occupational asthma, however the significance of a positive test is doubtful unless it can be reproduced by usual work exposures. We have compared the timing and responses during SIC in hospital to Oasys analysis of serial PEF during usual work exposures. METHODS: All workers with a positive SIC to occupational agents between 2006 and 2015 were asked to measure PEF 2-hourly from waking to sleeping for 4 weeks during usual occupational exposures...
May 10, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29748309/the-use-of-whole-genome-sequencing-in-cluster-investigation-of-an-mdr-tb-outbreak
#7
Maeve K Lalor, Nicola Casali, Timothy M Walker, Laura F Anderson, Jennifer A Davidson, Natasha Ratna, Cathy Mullarkey, Mike Gent, Kirsty Foster, Tim Brown, John Magee, Anne Barrett, Derrick W Crook, Francis Drobniewski, H Lucy Thomas, Ibrahim Abubakar
No abstract text is available yet for this article.
May 10, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29748308/fibroblast-growth-factor-23-and-klotho-contribute-to-airway-inflammation
#8
Stefanie Krick, Alexander Grabner, Nathalie Baumlin, Christopher Yanucil, Scott Helton, Astrid Grosche, Juliette Sailland, Patrick Geraghty, Liliana Viera, Derek W Russell, J Michael Wells, Xin Xu, Amit Gaggar, Jarrod Barnes, Gwendalyn D King, Michael Campos, Christian Faul, Matthias Salathe
Circulating levels of fibroblast growth factor (FGF) 23 are associated with systemic inflammation and increased mortality in chronic kidney disease. α-klotho, a co-receptor for FGF23, is downregulated in chronic obstructive pulmonary disease (COPD). However, whether FGF23 and klotho-mediated FGFR activation delineates a pathophysiologic mechanism in COPD remains unclear. We hypothesized that FGF23 can potentiate airway inflammation via klotho independent FGFR4 activation. FGF23 and its effect were studied using plasma and transbronchial biopsies from COPD and control patients and primary human bronchial epithelial cells isolated from COPD patients as well as a murine COPD model...
May 10, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29748307/infant-nasal-no-over-time-natural-evolution-and-impact-of-respiratory-tract-infection
#9
J K Marthin, M C Philipsen, S Rosthoj, K G Nielsen
No abstract text is available yet for this article.
May 10, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29748306/serum-25-hydroxyvitamin-d-levels-and-risk-of-lung-cancer-and-histologic-types-a-mendelian-randomisation-analysis-of-the-hunt-study
#10
Yi-Qian Sun, Ben M Brumpton, Carolina Bonilla, Sarah J Lewis, Stephen Burgess, Frank Skorpen, Yue Chen, Tom Il Nilsen, Pål Richard Romundstad, Xiao-Mei Mai
We aimed to investigate potential causal associations between serum 25-hydroxyvitamin D [25(OH)D] levels and incidence of lung cancer overall and histologic types.We performed a Mendelian randomization (MR) analysis using a prospective cohort study in Norway, including 54 580 individuals and 676 incident lung cancer cases. A 25(OH)D allele score was generated based on vitamin D-increasing alleles of rs2282679, rs12785878 and rs10741657. Hazard ratios (HRs) with 95% confidence intervals (CIs) for incidence of lung cancer and histologic types were estimated in relation to the allele score...
May 10, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29748305/three-month-daily-rifampicin-and-isoniazid-compared-to-six-or-nine-month-isoniazid-for-treating-latent-tuberculosis-infection-in-children-and-adolescents-less-than-15-years-of-age-an-updated-systematic-review
#11
LETTER
Yibeltal Assefa, Yalemzewod Assefa, Solomon Woldeyohannes, Yohhei Hamada, Haileyesus Getahun
No abstract text is available yet for this article.
May 10, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29748304/tobacco-smoke-exposure-in-early-life-and-adolescence-in-relation-to-lung-function
#12
Jesse D Thacher, Erica S Schultz, Jenny Hallberg, Ulrika Hellberg, Inger Kull, Per Thunqvist, Göran Pershagen, Per M Gustafsson, Erik Melén, Anna Bergström
Maternal smoking during pregnancy is associated with impaired lung function among young children, but less is known about long-term effects and the impact of adolescents' own smoking. We investigated the influence of maternal smoking during pregnancy, secondhand smoke exposure, and adolescent smoking on lung function at age 16 years.The BAMSE birth cohort collected information on participant's tobacco smoke exposure through repeated questionnaires, and measured saliva cotinine concentrations at age 16. Participants performed spirometry and impulse oscillometry (IOS) at age 16 (n=2295)...
May 10, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29724923/african-american-race-and-mortality-in-interstitial-lung-disease-a-multicenter-propensity-matched-analysis
#13
Ayodeji Adegunsoye, Justin M Oldham, Shashi K Bellam, Jonathan H Chung, Paul A Chung, Kathleen M Biblowitz, Steven Montner, Cathryn Lee, Scully Hsu, Aliya N Husain, Rekha Vij, Gokhan Mutlu, Imre Noth, Matthew M Churpek, Mary E Strek
No abstract text is available yet for this article.
May 3, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29724922/the-reproducibility-of-copd-blood-eosinophil-counts
#14
LETTER
Thomas Southworth, Gussie Beech, Philip Foden, Umme Kolsum, Dave Singh
No abstract text is available yet for this article.
May 3, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29724921/the-effect-of-anti-acid-therapy-on-survival-in-idiopathic-pulmonary-fibrosis-a-methodological-review-of-observational-studies
#15
Tanja Tran, Samy Suissa
BACKGROUND: International treatment guidelines for idiopathic pulmonary fibrosis (IPF) give a conditional recommendation for anti-acid therapy. As some observational studies reported discrepant findings on the effectiveness of anti-acid therapy on mortality in IPF, we reviewed all studies to evaluate whether immortal time bias explains these discrepancies. METHODS: We searched the EMBASE AND MEDLINE databases until July 2017 for observational studies assessing the effectiveness of anti-acid therapy on mortality in IPF...
May 3, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29724920/delamanid-for-rifampicin-resistant-tuberculosis-a-retrospective-study-from-south-africa
#16
Erika Mohr, Jennifer Hughes, Anja Reuter, Laura Trivino Duran, Gabriella Ferlazzo, Johnny Daniels, Virginia De Avezedo, Yulene Kock, Sarah Jane Steele, Amir Shroufi, Serge Ade, Natavan Alikhanova, Guido Benedetti, Jeffrey Edwards, Helen Cox, Jennifer Furin, Petros Isaakidis
BACKGROUND: Experience with delamanid (Dlm) is limited, particularly among HIV-positive individuals. We describe early efficacy and safety from a programmatic setting in South Africa. METHODS: This was a retrospective cohort study of patients receiving Dlm-containing treatment regimens between November 2015 and August 2017. Twelve-month interim outcomes, sputum culture conversion (SCC) by months-2 and 6, serious adverse events (SAEs), and QTcF data were reported...
May 3, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29724919/trend-of-rifampicin-resistant-mdr-and-xdr-tuberculosis-in-italy-2009-2016
#17
LETTER
Alessandro Mustazzolu, Emanuele Borroni, Daniela Maria Cirillo, Federico Giannoni, Angelo Iacobino, Lanfranco Fattorini
No abstract text is available yet for this article.
May 3, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29724918/management-appropriateness-and-outcomes-of-patients-with-acute-pulmonary-embolism
#18
David Jimenez, Behnood Bikdeli, Deisy Barrios, Raquel Morillo, Rosa Nieto, Ina Guerassimova, Alfonso Muriel, Luis Jara-Palomares, Lisa Moores, Victor Tapson, Roger D Yusen, Manuel Monreal
Background: Studies have not well defined the impact of adherence to published guidelines on the outcomes of patients with acute pulmonary embolism ( PE ). Methods: In this prospective cohort study of patients admitted to a respiratory department (N=2096), we evaluated whether patients with PE had better outcomes if they were acutely managed according to international guidelines. Outcomes consisted of all-cause mortality, PE-related mortality, recurrent venous thromboembolism ( VTE ), and major bleeding events during the first month of follow-up after diagnosis...
May 3, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29724917/reductions-in-dead-space-ventilation-with-nasal-high-flow-depend-on-physiologic-dead-space-volume-metabolic-hood-measurements-during-sleep-in-patients-with-copd-and-controls
#19
Paolo Biselli, Kathrin Fricke, Ludger Grote, Andrew T Braun, Jason Kirkness, Philip Smith, Alan Schwartz, Hartmut Schneider
Background: Nasal high flow (NHF) reduces minute ventilation and ventilatory loads during sleep but mechanisms are not clear. We hypothesized NHF reduces ventilation in proportion of the physiologic but not anatomic dead space. Methods: 11 subjects (5 Controls and 6 COPD) underwent a polysomnography with transcutaneous CO2 (tcCO2 ) monitoring under a metabolic hood. During stable NREM 2 sleep, subjects received NHF (20 L/min) intermittently for periods of 5-10 min. We measured CO2 production and calculated dead space ventilation...
May 3, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29700106/long-term-bedaquiline-related-treatment-outcomes-in-patients-with-extensively-drug-resistant-tuberculosis-from-south-africa
#20
Olatunde Olayanju, Jason Limberis, Aliasgar Esmail, Suzette Oelofse, Phindile Gina, Elize Pietersen, Mohammed Fadul, Rob Warren, Keertan Dheda
No abstract text is available yet for this article.
April 26, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
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