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European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology

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https://www.readbyqxmd.com/read/30409822/predictors-of-one-year-compliance-with-adaptive-servo-ventilation-in-patients-with-heart-failure-and-sleep-disordered-breathing-preliminary-data-from-the-advent-hf-trial
#1
LETTER
Elisa Perger, Owen D Lyons, Toru Inami, Stephanie Smith, John S Floras, Alexander G Logan, T Douglas Bradley
Peak flow-targeted adaptive servo ventilation (ASVpf) suppresses both obstructive (OSA) and central sleep apnoea (CSA). Although high hours of positive airway pressure (PAP) use improves quality of life, long-term compliance is problematic. We evaluated ASVpf use in patients with heart failure and reduced ejection fraction with either OSA or CSA to determine the short and long-term predictors of ASV pf compliance.Of 177 patients randomised to ASVpf, compliance data were available at one and 12 months post-randomisation in 91 with OSA and 45 with CSA...
November 8, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30409821/treatment-of-latent-tuberculosis-with-12-weeks-isoniazid-rifapentine-in-clinical-practice
#2
LETTER
Gabrielle Fröberg, Lena Jansson, Judith Bruchfeld
No abstract text is available yet for this article.
November 8, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30409820/determinants-of-diagnostic-delay-in-chronic-thromboembolic-pulmonary-hypertension-results-from-the-european-cteph-registry
#3
LETTER
Frederikus A Klok, Stefano Barco, Stavros V Konstantinides, Philippe Dartevelle, Elie Fadel, David Jenkins, Nick H Kim, Michael Madani, Hiromi Matsubara, Eckhard Mayer, Joanna Pepke-Zaba, Marion Delcroix, Irene M Lang
No abstract text is available yet for this article.
November 8, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30409819/digital-technologies-and-adherence-in-respiratory-diseases-the-road-ahead
#4
REVIEW
John D Blakey, Bruce G Bender, Alexandra L Dima, John Weinman, Guilherme Safioti, Richard W Costello
Outcomes for patients with chronic respiratory diseases remain poor despite the development of novel therapies. In part, this reflects the fact that adherence to therapy is low, and clinicians lack accurate methods to assess this issue. Digital technologies hold promise to overcome these barriers to care. For example, algorithmic analysis of large amounts of information collected on health status and treatment use, along with other disease relevant information such as environmental data, can be used to help guide personalised interventions that may have a positive health impact, such as establishing habitual and correct inhaler use...
November 8, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30409818/limitations-of-resting-haemodynamics-in-chronic-thromboembolic-disease-without-pulmonary-hypertension
#5
LETTER
Emilia Maria Swietlik, Alessandro Ruggiero, Andrew J Fletcher, Dolores Taboada, Emily Knightbridge, Louise Harlow, Ian Harvey, Nicholas Screaton, John E Cannon, Karen K K Sheares, Choo Ng, David P Jenkins, Joanna Pepke-Zaba, Mark R Toshner
No abstract text is available yet for this article.
November 8, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30409817/variable-radiologic-lung-nodule-evaluation-leads-to-divergent-management-recommendations
#6
A Nair, E C Bartlett, S L F Walsh, A U Wells, N Navani, G Hardavella, S Bhalla, L Calandriello, A Devaraj, J M Goo, J S Klein, H MacMahon, C Schaefer-Prokop, J B Seo, N Sverzellati, S R Desai
Radiologic evaluation of incidentally-detected lung nodules on computed tomography (CT) influences management. We assessed international radiologic variation in (1) pulmonary nodule characterisation; (2) hypothetical guideline-derived management, and (3) radiologists' management recommendations.107 radiologists from 25 countries evaluated 69 CT-detected nodules, recording: i) first-choice composition (solid, part-solid [PSN] or ground-glass [GGN], with percentage confidence), ii) morphologic features, iii) dimensions, iv) recommended management and (v) decision-influencing factors...
November 8, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30385530/autoimmunity-to-bactericidal-permeability-increasing-protein-in-bronchiectasis-exhibits-a-requirement-for-pseudomonas-aeruginosa-igg-response
#7
LETTER
Sladjana Skopelja-Gardner, Jomkuan Theprungsirikul, Rachel E Meagher, Cathleen M Beliveau, Katherine E Bradley, Meade Avery, Emily Henkle, Sarah Siegel, Alex H Gifford, Kevin L Winthrop, William F C Rigby
No abstract text is available yet for this article.
November 1, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30385529/innate-lymphoid-cells-in-the-upper-airways-importance-of-cd117-and-il-1ri-expression
#8
Koen Van Crombruggen, Sylvie Taveirne, Gabriele Holtappels, Georges Leclercq, Claus Bachert
Although innate lymphoid cells (ILC)1s, ILC2s and ILC3s are emerging as important cell populations regulating tissue homeostasis, remodelling and inflammation, a vast majority of our knowledge stems from in vitro and murine experiments, and requires thorough confirmation in human diseases.Relative levels of ILCs were evaluated by means of flow cytometry in freshly resected human upper airways mucosa of patients with chronic rhinosinusitis (CRS) without nasal polyps (NP) (CRSsNP) and with nasal polyps (CRSwNP), taking into account the patient's clinical parameters and disease comorbidities...
November 1, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30385528/obstructive-sleep-apnoea-and-venous-thromboembolism-pathophysiological-links-and-clinical-implications
#9
REVIEW
Alberto García-Ortega, Eva Mañas, Raquel López-Reyes, María José Selma, Aldara García, Grace Oscullo, David Jiménez, Miguel Ángel Martínez-García
Obstructive sleep apnoea (OSA) and pulmonary embolism (PE) remain a major health issue worldwide. Data from pathophysiological studies suggest that both intermittent hypoxia and sleep fragmentation are associated with increased blood coagulability, endothelial dysfunction and venous stasis. There is growing evidence that OSA is potentially prevalent and a risk factor for PE. Conversely, patients with acute PE have patients with acute PE have two to four times greater risk of moderate-to-severe OSA. The role of continuous positive airway pressure (CPAP) treatment in improving clinically meaningful outcomes in PE patients remains unclear, although some authors have suggested that CPAP could improve the hypercoagulability state and normalise circadian alterations in some of the coagulation molecules, as observed in patients with OSA...
November 1, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30361253/compassionate-use-of-delamanid-in-combination-with-bedaquiline-for-the-treatment-of-mdr-tb
#10
LETTER
Jeffrey Hafkin, Norbert Hittel, Alexandra Martin, Rajesh Gupta
No abstract text is available yet for this article.
October 25, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30361252/ers-statement-on-harmonised-standards-for-lung-cancer-registration-and-lung-cancer-services-in-europe
#11
A L Rich, D R Baldwin, P Beckett, T Berghmans, J Boyd, C Faivre-Finn, F Galateau-Salle, F Gamarra, B Grigoriu, N C Hansen, G Hardavella, E Jakobsen, D Jovanovic, A Konsoulova, G Massard, J McPhelim, A P Meert, R Milroy, L Mutti, M Paesmans, M D Peake, P M Putora, D de Ruysscher, J P Sculier, A Schepereel, D Subotic, P Van Schil, T G Blum
INTRODUCTION: The European Respiratory Society taskforce for harmonised standards for lung cancer registration and lung cancer services in Europe recognised the need to create a single dataset for use in pan-European data collection, and a manual of standards for European lung cancer services. METHODS: Existing national and international datasets were reviewed with the results of a survey of clinical data collection on lung cancer in 35 European countries. These two different sources of evidence were considered by the multidisciplinary taskforce...
October 25, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30361251/estimating-the-prevalence-of-latent-tuberculosis-in-a-low-incidence-setting-australia
#12
K D Dale, J M Trauer, P J Dodd, R M G J Houben, J T Denholm
Migration is a key driver of tuberculosis (TB) in many low incidence settings, with the majority of TB cases attributed to reactivation of latent TB (LTBI) acquired overseas. A greater understanding of LTBI risk in heterogeneous migrant populations would aid health planning. We aimed to estimate the LTBI prevalence and distribution among local and overseas-born Australians.Annual risks of tuberculosis infection estimates were applied to population cohorts (by country of birth, year of arrival and age) in Australian census data in 2006, 2011 and 2016...
October 25, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30361250/sertraline-in-symptomatic-chronic-breathlessness-a-double-blind-randomised-trial
#13
David C Currow, Magnus Ekstrӧm, Sandra Louw, Julie Hill, Belinda Fazekas, Katherine Clark, Patricia M Davidson, Christine McDonald, Dimitar Sajkov, Nikki McCaffrey, Matthew Doogue, Amy P Abernethy, Meera Agar
Does sertraline provide symptomatic relief for chronic breathlessness in people with advanced disease whose underlying cause(s) are optimally treated?Two hundred and twenty three participants with chronic breathlessness (modified Medical Research Council (mMRC) breathlessness scale ≥2) who had optimal treatment of underlying cause(s) were randomised 1:1 to sertraline 25 mg-100 mg (titrated upwards over nine days) or placebo for four weeks. The primary outcome was the proportion who had an improvement in intensity of current breathlessness >15% from baseline on a 100 mm visual analogue scale (VAS)...
October 25, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30361249/ers-technical-standard-on-bronchial-challenge-testing-pathophysiology-and-methodology-of-indirect-airway-challenge-testing
#14
Teal S Hallstrand, Joerg D Leuppi, Guy Joos, Graham L Hall, Kai-Håkon Carlsen, David A Kaminsky, Allan L Coates, Donald W Cockcroft, Bruce H Culver, Zuzana Diamant, Gail M Gauvreau, Ildiko Horvath, F H C de Jongh, Beth L Laube, P J Sterk, Jack Wanger
Recently this international task force reported the general considerations for bronchial challenge testing and the performance of the methacholine challenge test, a "direct" airway challenge test. Here the task force provides an updated description of the pathophysiology and the methods to conduct indirect challenge tests. Because indirect challenge tests trigger airway narrowing through the activation of endogenous pathways that are involved in asthma, indirect challenge tests tend to be specific for asthma and reveal much about the biology of asthma, but may be less sensitive than direct tests for the detection of airway hyperresponsiveness...
October 25, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30361248/benefits-of-supervised-community-physical-activity-in-obstructive-sleep-apnoea
#15
LETTER
Mathieu Berger, Jean-Claude Barthélémy, David Hupin, Jérémy Raffin, Caroline Dupré, Pierre Labeix, Frédéric Costes, Jean-Michel Gaspoz, Frédéric Roche
No abstract text is available yet for this article.
October 25, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30361247/randomised-controlled-trials-in-severe-asthma-selection-by-phenotype-or-stereotype
#16
Thomas Brown, Thomas Jones, Kerry Gove, Clair Barber, Scott Elliott, Anoop Chauhan, Peter Howarth
BACKGROUND: Previous publications have highlighted the disparity between research trial populations and clinical practise but it is not established how this relates to randomised controlled trials (RCTs) of phenotype targeted biological therapies in severe asthma. METHODS: Detailed characterisation data for 342 severe asthma patients within the Wessex Severe Asthma Cohort (WSAC) was compared against comprehensive trial eligibility criteria for published phase IIB and III RCTs evaluating biological therapies in severe asthma since 2000...
October 25, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30361246/high-treatment-success-rate-for-multidrug-resistant-and-extensively-drug-resistant-tuberculosis-using-a-bedaquiline-containing-treatment-regimen
#17
Norbert Ndjeka, Kathryn Schnippel, Iqbal Master, Graeme Meintjes, Gary Maartens, Rodolfo Romero, Xavier Padanilam, Martin Enwerem, Sunitha Chotoo, Nalini Singh, Jennifer Hughes, Ebrahim Variava, Hannetjie Ferreira, Julian Te Riele, Nazir Ismail, Erika Mohr, Nonkqubela Bantubani, Francesca Conradie
Background: South African patients with rifampicin-resistant tuberculosis and resistance to fluoroquinolones and/or injectables (pre/XDR-TB) were granted access to bedaquiline through a Clinical Access Programme with strict inclusion and exclusion criteria. Methods: Pre/XDR-TB and XDR-TB patients were treated with 24 weeks bedaquiline within an optimised, individualised background regimen that could include levofloxacin, linezolid and clofazimine as needed. Results: 200 patients were enrolled: 87 (43.9%) with XDR-TB, 99 (49...
October 25, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30361245/patterns-of-regional-lung-physiology-in-cystic-fibrosis-using-ventilation-mri-and-mbw
#18
Laurie J Smith, Guilhem J Collier, Helen Marshall, Paul J C Hughes, Alberto M Biancardi, Martin Wildman, Ina Aldag, Noreen West, Alex Horsley, Jim M Wild
Hyperpolarised helium-3 (3 He) ventilation MRI and multiple-breath washout (MBW) are sensitive methods for detecting lung disease in cystic fibrosis (CF). We aimed to explore their relationship across a broad range of CF disease severity and patient age, as well as assess the effect of inhaled lung volume on ventilation distribution.32 children and adults with CF underwent MBW and 3 He-MRI at a lung volume of end-inspiratory tidal volume (EIVt). 28 patients also performed 3 He-MRI at total lung capacity (TLC)...
October 25, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30361244/pathological-mucus-and-impaired-mucus-clearance-in-cystic-fibrosis-patients-results-from-increased-concentration-not-altered-ph
#19
David B Hill, Robert F Long, William J Kissner, Eyad Atieh, Ian C Garbarine, Matthew R Markovetz, Nicholas C Fontana, Matthew Christy, Mehdi Habibpour, Robert Tarran, M Gregory Forest, Richard C Boucher, Brian Button
Cystic fibrosis (CF) is a recessive genetic disease that is characterised by airway mucus plugging and reduced mucus clearance. There are currently alternative hypotheses that attempt to describe the abnormally viscous and elastic mucus that is a hallmark of CF airways disease, including: a) loss of cystic fibrosis transmembrane regulator (CFTR)-dependent airway surface volume (water) secretion, producing mucus hyper-concentration-dependent increased viscosity; and b) impaired bicarbonate secretion by CFTR, producing acidification of airway surfaces and increased mucus viscosity...
October 25, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30361243/dramatic-response-of-refractory-sarcoidosis-under-ruxolitinib-in-a-patient-with-associated-jak2-mutated-polycythemia
#20
LETTER
Cécile Rotenberg, Valérie Besnard, Pierre-Yves Brillet, Stéphane Giraudier, Hilario Nunes, Dominique Valeyre
No abstract text is available yet for this article.
October 25, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
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