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Clinical and Experimental Rheumatology

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https://www.readbyqxmd.com/read/28134076/the-prevalence-of-beh%C3%A3-et-s-disease-in-korea-data-from-health-insurance-review-and-assessment-service-from-2011-to-2015
#1
Ji Na Kim, Sang Gyu Kwak, Jung-Yoon Choe, Seong-Kyu Kim
OBJECTIVES: The aim of this study is to identify the prevalence of Behçet's disease (BD) from data in the Healthcare Bigdata Hub of the Health Insurance Review & Assessment (HIRA) Service from 2011 to 2015 in Korea. METHODS: This study collected information on primary and auxiliary diagnoses of BD (M352) by physicians according to the Korean Standard Classification of Diseases (KCD) codes. The prevalence of BD was assessed on the basis of age, sex, and geographical distribution...
January 30, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28134089/foot-involvement-in-systemic-lupus-erythematosus-more-than-joint-disease
#2
Keith Rome, Nicola Dalbeth, Paul Jarrett, Sunil Kumar, Matthew Carroll, Alhana Clendon, Peter Gow
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January 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28134088/evolving-spectrum-of-lrba-deficiency-associated-chronic-arthritis-is-there-a-causative-role-in-juvenile-idiopathic-arthritis
#3
Sulaiman M Al-Mayouf, Hamzah Naji, Khalid Alismail, Anas M Alazami, Farrukh Sheikh, Walter Conca, Hamoud Al-Mousa
Lipopolysaccharide-responsive, beige-like anchor protein (LRBA) deficiency causes common variable immunodeficiency (CVID) disorders and autoimmunity. LRBA deficiency has become a clinically variable syndrome with a wide spectrum of clinical manifestations. We report a patient with LRBA deficiency associated chronic non-erosive arthritis. This report highlights the spectrum of arthritis in such patients and the potential causative role of LRBA gene in juvenile arthritis.
January 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28134087/henoch-sch%C3%A3-nlein-purpura-iga-vasculitis-the-paradox-of-the-different-incidence-and-clinical-spectrum-in-children-and-adults
#4
EDITORIAL
Miguel A González-Gay, Ricardo Blanco, Santos Castañeda
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January 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28134086/the-spectrum-of-early-rheumatoid-arthritis-practice-across-the-globe-results-from-a-multinational-cross-sectional-survey
#5
Elena Nikiphorou, James Galloway, Piet van Riel, Yusuf Yazici, Glenn Haugeberg, Andrew Ostor, Feride Gogus, Markku Kauppi, Tuulikki Sokka
OBJECTIVES: To explore patterns of real-world early RA (ERA) care across countries. METHODS: An online survey was disseminated to practising rheumatologists across Europe and the US, also made accessible on social media between April and May 2015. Survey questions (n=38) assessed the structure and setting of ERA clinics, times to diagnosis and treatment, patient monitoring, guideline use and data recording. RESULTS: A total of 212 rheumatologists from 39 countries (76% European) completed the survey...
January 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28134084/pneumocystis-jiroveci-pneumonia-in-rheumatic-disease-a-20-year-single-centre-experience
#6
Christopher A Mecoli, Deanna Saylor, Allan C Gelber, Lisa Christopher-Stine
OBJECTIVES: Pneumocystis jiroveci pneumonia (PJP) is an opportunistic infection with high mortality among patients with underlying rheumatologic conditions. Given the paucity of prospective data to guide treatment, clinical guidelines to initiate PJP prophylaxis are based on expert opinion and identify patients on ≥20 mg daily prednisone for ≥4 weeks duration for treatment. Herein we describe the PJP experience in rheumatic disease over a 20-year period at a single academic medical centre to investigate this 20 mg threshold and risk associated with lymphocyte counts, co-existing lung disease and immunosuppressive medications...
January 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28134083/direct-suppression-of-autoaggressive-cd8-t-cells-with-cd80-86-blockade-in-cd8-t-cell-mediated-polymyositis-models-of-mice
#7
Hisanori Hasegawa, Kimito Kawahata, Fumitaka Mizoguchi, Naoko Okiyama, Nobuyuki Miyasaka, Hitoshi Kohsaka
OBJECTIVES: CD80/86 blockade to inhibit CD28 costimulation suppressed alloreactive human and murine CD4+ T cells but not alloreactive CD8+ T cells. In contrast, CD28 costimulation augments CD8+ T cell-mediated cell lysis in antigen-nonspecific stimulation. The present study was conducted to discern whether the CD80/86 blockade exerts therapeutic effects on CD8+ T cell-mediated polymyositis (PM) models of mice and whether the effects could be attributable to direct suppression of autoantigen-specific CD8+ T cells...
January 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28134082/transfusion-related-acute-lung-injury-in-a-patient-with-systemic-lupus-erythematosus
#8
Eleftherios Pelechas, Nafsika Gerolymatou, Paraskevi V Voulgari, Alexandros A Drosos
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January 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28134081/detecting-novel-micro-rnas-in-rheumatoid-arthritis-with-gene-based-association-testing
#9
Aleksander Lenert, David W Fardo
OBJECTIVES: To identify novel risk genes by gene-based association analysis in rheumatoid arthritis (RA). METHODS: We performed gene-based association testing with GATES (Gene-based Association Test using Extended Simes procedure) to augment the power of genomewide-association study (GWAS) results from the largest meta-GWAS by Okada et al. in 14,361 RA cases and 43,923 controls of European ancestry using 8,694,488 SNPs. RESULTS: We identified 115 genes significantly associated with RA by gene-based association testing corresponding to 43 RA risk loci; 23 risk loci contained a single top risk gene, while 20 risk loci contained two or more risk genes...
January 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28134080/enhanced-gut-homing-receptor-expression-of-unswitched-memory-b-cells-in-rheumatoid-arthritis
#10
Yasuo Nagafuchi, Hirofumi Shoda, Shuji Sumitomo, Shinichiro Nakachi, Rika Kato, Yumi Tsuchida, Haruka Tsuchiya, Keiichi Sakurai, Norio Hanata, Shoko Tateishi, Hiroko Kanda, Keishi Fujio, Kazuhiko Yamamoto
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January 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28134079/development-and-validation-of-rheumatoid-arthritis-magnetic-resonance-imaging-inflammation-thresholds-associated-with-lack-of-damage-progression
#11
Joshua F Baker, Mikkel Østergaard, Paul Emery, Daniel G Baker, Philip G Conaghan
OBJECTIVES: To determine thresholds for rheumatoid arthritis (RA) magnetic resonance imaging scores (RAMRIS) associated with a low risk of structural damage progression. METHODS: MRI of the dominant hand was performed and RAMRIS scores determined at weeks 0, 24, and 52. X-rays were performed and van der Heijde-Sharp scores (vdHS) determined. In a development cohort (n=297) the changes in MRI erosion score and vdHS score were determined over the 24-week to 52-week interval and progression was defined as change >0...
January 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28134078/diagnosis-and-treatment-of-rheumatoid-arthritis-in-the-emilia-romagna-region-a-prospective-population-based-study
#12
Olga Addimanda, Massimiliano Marino, Ilaria Farina, Marica Trevisani, Eugenio Arrigoni, Federica Lumetti, Filippo Crescentini, Paola Sambo, Alessandra Bezzi, Marco Bruschi, Daniele Santilli, Massimo Reta, Simona Bosi, Giovanni Delsante, Francesco Girelli, Luca Montaguti, Riccardo Meliconi, Marco Sebastiani, Clodoveo Ferri, Nazzarena Malavolta, Marcello Govoni, Susanna Trombetti, Rossana De Palma, Carlo Salvarani
OBJECTIVES: To perform a population-based study in rheumatoid arthritis (RA) patients, in order to evaluate the efficacy and safety of pharmacologic treatments. METHODS: 1087 patients with RA were enrolled; inclusion criteria were: newly diagnosed RA, already diagnosed RA with high disease activity (HDA) (DAS28≥4.2) starting biologic DMARDs (bDMARDs), already diagnosed RA with HDA continuing with conventional DMARDs (cDMARDs). The following data were collected: demographics, clinical and laboratory features, imaging and prescribed drugs...
January 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28134077/dual-endothelin-receptor-antagonists-contrast-the-effects-induced-by-endothelin-1-on-cultured-human-microvascular-endothelial-cells
#13
Stefano Soldano, Sabrina Paolino, Carmen Pizzorni, Amelia Chiara Trombetta, Paola Montagna, Renata Brizzolara, Claudio Corallo, Nicola Giordano, Alberto Sulli, Maurizio Cutolo
OBJECTIVES: To evaluate the ability of dual endothelin (ET) receptor antagonists (ETA/ETB -ETA/BRAs) to contrast the ET-1-induced effects on cultured human microvascular endothelial cells (HMVECs). METHODS: Some cultured HMVECs were untreated, or treated with ET-1 (100nM) or transforming growth factor β1 (TGFβ1, 10ng/mL) alone for 6 days, in order to induce the endothelial-to-mesenchymal transition (EndoMT). Other cultured HMVECs were pre-treated for 1hr with ETA/BRAs bosentan (10μM) or macitentan (1μM, 10μM) before the stimulation with ET-1 for 6 days...
January 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28134085/digenic-mefv-tnfrsf1a-autoinflammatory-syndrome-with-relapsing-aseptic-neutrophilic-meningitis-and-chronic-myelitis
#14
Anne Murarasu, Catherine Dodé, Guillaume Sarrabay, Isabelle Klein, Thomas Papo, Karim Sacré
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January 26, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28134075/cyclophosphamide-followed-by-rituximab-for-aggressive-multiple-relapsing-antineutrophil-cytoplasmic-antibody-associated-vasculitis
#15
Sophia Lionaki, George E Fragoulis, Aliki Venetsanopoulou, Panagiotis Vlachoyiannopoulos, John N Boletis, Athanasios G Tzioufas
OBJECTIVES: To evaluate the long term outcomes of patients with multi-relapsing antineutrophil cytoplasmic antibody-associated vasculitis (AAV), who received sequentially therapy with cyclophosphamide and rituximab, upon new onset of aggressive vasculitis. METHODS: We retrospectively studied patients with multiple-relapsing AAV, who were treated with the standard regimen plus rituximab, given in sequence, upon a major relapse, compared to historical patients, who had been treated with the standard regimen alone in the same setting...
January 25, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28134073/long-term-continuation-of-methotrexate-therapy-in-giant-cell-arteritis-patients-in-clinical-practice
#16
Leticia Leon, Luis Rodriguez-Rodriguez, Dalifer Freites, Lucia Arietti, Inmaculada Morado, Cristina Vadillo, José Ramón Lamas, Benjamin Fernandez, Juan Angel Jover, Lydia Abasolo
OBJECTIVES: To assess the long-term continuation of MTX in a cohort of patients with GCA in daily clinical practice. Factors associated with its discontinuation rate were also investigated. METHODS: A longitudinal study from 1991-2014, was performed. GCA patients with MTX and followed-up in a rheumatology outpatient clinic of Madrid during the study period were included. PRIMARY OUTCOME: discontinuation of MTX due to: adverse drug reaction (ADR moderate and severe); inefficacy; sustained clinical response; patient decision...
January 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28134074/chest-and-renal-involvements-birmingham-vascular-activity-score-more-than-13-5-and-five-factor-score-1996-more-than-1-at-diagnosis-are-significant-predictors-of-relapse-of-microscopic-polyangiitis
#17
Yoon-Jeong Oh, Sung Soo Ahn, Eun Seong Park, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
OBJECTIVES: We investigated whether specified organ involvements, antineutrophil cytoplasmic antibody (ANCA) positivity, Birmingham vasculitis activity score (BVAS) and five factor scores (FFS) at diagnosis could predict relapse of microscopic polyangiitis (MPA). METHODS: We reviewed the medical records of 90 patients with MPA. We collected clinical and prognostic data, (MPO)-ANCA and proteinase 3 (PR3)-ANCA, BVAS and FFS at diagnosis, and we compared them between the two groups...
January 19, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28094760/treat-to-target-biologic-therapy-in-patients-with-rheumatoid-arthritis-is-more-efficacious-and-safe-compared-to-delayed-initiation-of-biologics-a-real-world-study
#18
Christos E Lampropoulos, Philippos Orfanos, Menelaos N Manoussakis, Athanasios G Tzioufas, Haralampos M Moutsopoulos, Panayiotis G Vlachoyiannopoulos
OBJECTIVES: Rheumatoid arthritis (RA) is a chronic, devastating disease. Treat-to-target strategy (T2T) more than the usual care, reduces disease activity by using aggressively all therapeutic options. The aim of the study was to evaluate our hypothesis that T2T strategy using biologic disease-modifying anti-rheumatic drugs (bDMARDs), when needed, is also safer than the usual care characterised by delayed initiation of bDMARDs. METHODS: Disease activity was regularly measured by DAS-28 until the end of treatment with the first bDMARD...
January 16, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28094757/which-joints-and-why-do-rheumatologists-scan-in-rheumatoid-arthritis-by-ultrasonography-a-real-life-experience
#19
Sibel Zehra Aydin, Salih Pay, Nevsun Inanc, Sevil Kamali, Omer Karadag, Paul Emery, Maria-Antonietta D'Agostino
OBJECTIVES: Ultrasonography (US) has been demonstrated to improve assessment of synovitis and disease activity in rheumatoid arthritis (RA). However, the utility and feasibility of US in RA in clinical practice in real life is not known. We aimed to investigate: i) the indications for performing US in RA in daily practice; and ii) whether the number of scanned joints varies according to the purpose. METHODS: Consecutive patients who had a US scan either for diagnosis or follow-up for RA from 5 centres were recruited...
January 15, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28094756/treatment-modifying-factors-of-biologics-for-psoriatic-arthritis-a-systematic-review-and-bayesian-meta-regression
#20
REVIEW
Eric Druyts, Jacqueline B Palmer, Chakrapani Balijepalli, Keith Chan, Mir Sohail Fazeli, Vivian Herrera, Jeroen P Jansen, Jay J H Park, Steve Kanters, Andreas Reimold
OBJECTIVES: The aim of this study was to explore factors that modify treatment effects of non-conventional biologics versus placebo in patients with psoriatic arthritis. METHODS: A systematic literature review and meta-regression was conducted. The biologics included etanercept, infliximab, adalimumab, golimumab, certolizumab, ustekinumab, tocilizumab, anakinra, abatacept, rituximab, and secukinumab. Outcomes included American College of Rheumatology (ACR) 20 and 50, Psoriasis Area Severity Index (PASI) 75, and 36-Item Short Form Health Survey (SF-36) Physical and Mental Component Summaries (PCS and MCS)...
January 15, 2017: Clinical and Experimental Rheumatology
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