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Clinical and Experimental Rheumatology

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https://www.readbyqxmd.com/read/28339366/jaccoud-s-arthropathy-in-systemic-lupus-erythematosus-clinical-laboratory-and-ultrasonographic-features
#1
Fulvia Ceccarelli, Laura Massaro, Carlo Perricone, Monica Pendolino, Enrica Cipriano, Simona Truglia, Francesca Miranda, Francesca Romana Spinelli, Cristiano Alessandri, Guido Valesini, Fabrizio Conti
OBJECTIVES: Jaccoud's arthropathy (JA) is a deforming, non-erosive arthritis, occurring in 2-35% of systemic lupus erythematosus (SLE) patients. We aimed to evaluate JA patients in a wide monocentric SLE cohort in terms of clinical, serological and ultrasonographic features. METHODS: Consecutive SLE patients (ACR criteria 1997) were evaluated. The JA index was applied for patients with reducible deformities. Patients with a JA index ≥5 underwent physical examination, blood testing and ultrasound (US) assessment...
March 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28339365/thresholds-for-the-28-joint-disease-activity-score-das28-using-c-reactive-protein-are-lower-compared-to-das28-using-erythrocyte-sedimentation-rate-in-early-rheumatoid-arthritis
#2
Bindee Kuriya, Orit Schieir, Daming Lin, Juan Xiong, Janet Pope, Gilles Boire, Boulos Haraoui, John Carter Thorne, Diane Tin, Carol Hitchon, Shahin Jamal, Edward Keystone, Vivien P Bykerk
OBJECTIVES: The 28-Joint Disease Activity Score (DAS28) using C-reactive protein (CRP) and DAS28 using erythrocyte sedimentation rate (DAS28-ESR) may not be interchangeable. We sought to compare and estimate optimal thresholds for the DA28-CRP for use in early rheumatoid arthritis (ERA). METHODS: Patients from the Canadian Early Arthritis Cohort with baseline and 12 months' data for both DAS28-ESR and DAS28-CRP were examined for correlations and differences between DAS28-CRP and DAS28-ESR across their range of values...
March 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28339364/clinical-and-prognostic-features-of-korean-patients-with-mpo-anca-pr3-anca-and-anca-negative-vasculitis
#3
Juyoung Yoo, Ho Jae Kim, Sung Soo Ahn, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
OBJECTIVES: We reclassified Korean patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) into 3 categories of AAV including MPO-ANCA, PR3-ANCA and ANCA negative vasculitis, and investigated clinical and prognostic features. METHODS: We reviewed the medical records of 133 patients with microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) and eosinophilic GPA (EGPA), who had having either myeloperoxidase (MPO)-ANCA, proteinase 3 (PR3)-ANCA or no ANCA, and who had ever achieved the first remission...
March 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28339363/proangiogenic-gene-polymorphisms-are-associated-with-susceptibility-to-paget-s-disease-of-bone-and-with-its-clinical-features
#4
Ismael Calero-Paniagua, Ricardo Usategui-Martín, Luís Corral-Gudino, Judit García-Aparicio, Javier Del Pino-Montes, Rogelio González-Sarmiento
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March 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28339360/critical-role-of-stir-mri-in-early-detection-of-post-streptococcal-periostitis-with-dysproteinaemia-goldbloom-s-syndrome
#5
Riccardo Papa, Alessandro Consolaro, Francesca Minoia, Roberta Caorsi, Gianmichele Magnano, Marco Gattorno, Angelo Ravelli, Paolo Picco
OBJECTIVES: In 1966, Goldbloom et al. described two children who developed a peculiar clinical picture characterized by intermittent daily bone pain in the lower limbs, fever spikes, increased acute phase reactants and dysproteinaemia. The syndrome occurred two weeks after a group A β-haemolytic streptococcus infection. So far, only a few cases have been reported in the medical literature in English. METHODS: We report two further cases of Goldbloom's syndrome with a review of the literature in English...
March 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28339358/effectiveness-and-healthcare-costs-among-stabilised-rheumatoid-arthritis-patients-with-dose-reduction-of-adalimumab-or-etanercept-in-real-world
#6
Min Yang, Philip J Galebach, James E Signorovitch, Vishvas Garg
OBJECTIVES: We assessed the level of maintained effectiveness and associated healthcare costs in stabilised rheumatoid arthritis (RA) patients who reduced doses of adalimumab or etanercept. METHODS: Eligible patients were identified from a U.S. commercial insurance database using the following criteria: adults with ≥2 RA diagnoses; effectively treated on standard dose of adalimumab or etanercept for a 6-month baseline period; and ≥3 months of dose reduction within a 6-month assessment period following the index date (date of the first reduced dose)...
March 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28339356/diagnostic-accuracy-of-musculoskeletal-ultrasound-and-conventional-radiography-in-the-assessment-of-the-wrist-triangular-fibrocartilage-complex-in-patients-with-definite-diagnosis-of-calcium-pyrophosphate-dihydrate-deposition-disease
#7
Andrea Di Matteo, Emilio Filippucci, Fausto Salaffi, Marina Carotti, Davide Carboni, Eleonora Di Donato, Walter Grassi
OBJECTIVES: To compare the diagnostic accuracy of musculoskeletal ultrasound (MSUS) and x-ray in evaluating wrist triangular fibrocartilage complex (TFCC) in patients with calcium pyrophosphate dihydrate deposition disease (CPPD) and to investigate the agreement between the extent of the calcium pyrophosphate dihydrate (CPP) crystal deposits assessed by MSUS and the radiographic findings. METHODS: We enrolled 84 patients: 36 patients with "definite" CPPD and 48 controls...
March 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28339355/psychometric-properties-of-sleep-and-coping-numeric-rating-scales-in-rheumatoid-arthritis-a-subanalysis-of-an-etanercept-trial
#8
Pedro Avila-Ribeiro, Yves Brault, Maxime Dougados, Laure Gossec
OBJECTIVES: In rheumatoid arthritis, quality of sleep and ability to cope are important for patients; however their usefulness as outcome measures is not well established. METHODS: Post-hoc analysis of an open-label 12-week trial of etanercept in biologic-naïve rheumatoid arthritis patients with visits at screening, baseline and over 12 weeks. Outcomes measured included Disease Activity Score 28 erythrocyte sedimentation rate (DAS28), numeric rating scales for sleep, coping, patient and physician-global assessment, pain and fatigue, and modified-HAQ...
March 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28339354/the-effects-of-an-educational-meeting-and-subsequent-computer-reminders-on-the-ordering-of-laboratory-tests-by-rheumatologists-an-interrupted-time-series-analysis
#9
Nienke Lesuis, Nathan den Broeder, Nadine Boers, Ester Piek, Steven Teerenstra, Marlies Hulscher, Ronald van Vollenhoven, Alfons A den Broeder
OBJECTIVES: To examine the effects of an educational meeting and subsequent computer reminders on the number of ordered laboratory tests. METHODS: Using interrupted time series analysis we assessed whether trends in the number of laboratory tests ordered by rheumatologists between September 2012 and September 2015 at the Sint Maartenskliniek (the Netherlands) changed following an educational meeting (September 2013) and the introduction of computer reminders into the Computerised Physician Order Entry System (July 2014)...
March 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28339362/diagnostic-performance-of-color-duplex-ultrasonography-along-with-temporal-artery-biopsy-in-suspicion-of-giant-cell-arteritis
#10
Christophe Roncato, Caroline Allix-Béguec, Elisabeth Brottier-Mancini, Bruno Gombert, Guillaume Denis
OBJECTIVES: Giant cell arteritis (GCA) is a vasculitis that occurs in older adults, affecting vessels of medium and large caliber. GCA diagnosis is a challenge for general practitioners and specialists. The aim of this study was to retrospectively analyse performances of temporal artery biopsy (TAB) and color duplex ultrasonography (CDU) for GCA diagnosis. METHODS: All patients with suspicion of GCA and who underwent both TAB and CDU between April 2009 and March 2014 were included in the study...
March 20, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28339359/cardiac-involvement-as-a-presenting-feature-of-eosinophilic-granulomatosis-with-polyangiitis-in-childhood
#11
Timothy D Reynolds, Catherine Armstrong, Athimalaipet V Ramanan
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March 15, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28339357/development-of-a-score-for-assessment-of-radiologic-damage-in-large-vessel-vasculitis-combined-arteritis-damage-score-cards
#12
Daiki Nakagomi, Claire Cousins, Jan Sznajd, Shunsuke Furuta, Aladdin J Mohammad, Raashid Luqmani, David Jayne
OBJECTIVES: Outcome assessment in large-vessel vasculitis (LVV) remains challenging and this impairs patient management and the conduct of clinical studies. Previous proposals for outcome tools have not included imaging. This study aimed to develop an imaging score to quantify damage in LVV and to assess the difference between Takayasu (TAK) and giant cell arteritis (GCA). METHODS: Ninety-six patients (41 TAK, 55 GCA) were identified from local registries at two University Hospitals in the UK...
March 13, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28339361/anti-n-methyl-d-aspartate-receptor-antibodies-are-associated-with-fibromyalgia-in-patients-with-systemic-lupus-erythematosus-a-case-control-study
#13
Dong-Jin Park, Yukitoshi Takahashi, Ji-Hyoun Kang, Yi-Rang Yim, Ji-Eun Kim, Jeong-Won Lee, Kyung-Eun Lee, Jung-Kil Lee, Shin-Seok Lee
OBJECTIVES: The high concordance between systemic lupus erythematosus (SLE) and fibromyalgia (FM) suggests common underlying mechanisms related to pain and distress in both patient groups. Increasing evidence indicates that N-methyl-D-aspartate receptors (NMDARs) play a major role in the induction and maintenance of central sensitisation with chronic pain. In this study, we evaluated the role of anti-NMDAR antibodies in the development of FM in patients with SLE. METHODS: Sera from 104 patients with SLE, 112 patients with FM, and 110 healthy controls were analysed to detect antibodies to the N-terminus of the 2B subunit of NMDARs (GluN2B)...
March 10, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28281457/evaluation-of-the-effect-of-sildenafil-on-the-microvascular-blood-flow-in-patients-with-systemic-sclerosis-a-randomised-double-blind-placebo-controlled-study
#14
Fernando V Andrigueti, Pâmela C C Ebbing, Maria I Arismendi, Cristiane Kayser
OBJECTIVES: To evaluate the effect of sildenafil as add-on therapy on the microvascular blood flow in patients with Raynaud's phenomenon (RP) secondary to systemic sclerosis (SSc). METHODS: In this double-blind, placebo-controlled study, 41 patients with RP secondary to SSc were randomly assigned to receive oral sildenafil 100 mg/day (21 patients, mean age 47.2 years) or placebo (20 patients, mean age 41.6 years) for 8 weeks. Patients were evaluated at baseline, 8 weeks after treatment, and 2 weeks after the end of the treatment...
March 9, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28281455/assessment-of-the-current-inflammatory-back-pain-criteria-in-patients-with-fibromyalgia
#15
Euthalia Roussou, Andreas Georgiou
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March 9, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28281464/decreased-antibodies-against-hepatitis-a-in-previously-vaccinated-treatment-na%C3%A3-ve-juvenile-sle-patients-a-prospective-case-control-study
#16
Despoina N Maritsi, Despina Eleftheriou, Margarita Onoufriou, George Vartzelis
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March 8, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28281461/type-i-interferon-signature-may-influence-the-effect-of-belimumab-on-immunoglobulin-levels-including-rheumatoid-factor-in-sj%C3%A3-gren-s-syndrome
#17
Luca Quartuccio, Clio P Mavragani, Adrianos Nezos, Saviana Gandolfo, Athanasios G Tzioufas, Salvatore De Vita
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March 8, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28281456/insulin-resistance-in-systemic-lupus-erythematosus-patients-contributing-factors-and-relationship-with-subclinical-atherosclerosis
#18
Hiurma Sánchez-Pérez, Beatriz Tejera-Segura, Antonia de Vera-González, Alejandra González-Delgado, José Manuel Olmos, José Luis Hernández, Alfonso Corrales, Raquel López-Mejías, Miguel Angel González-Gay, Iván Ferraz-Amaro
OBJECTIVES: Insulin resistance (IR) plays a role in the increased cardiovascular risk of systemic lupus erythematosus (SLE) patients. This study aimed to determine the potential association of IR with disease activity, drug exposure and subclinical atherosclerosis in patients with SLE. METHODS: This cross-sectional study encompassed 87 non-diabetic SLE patients and 82 sex-matched controls. Insulin and C-peptide serum levels, IR indexes by homeostatic model assessment (HOMA2) (both insulin-based: HOMA2-IR, and with C-peptide: HOMA2-IR-C-peptide) and lipid profiles were assessed in patients and controls...
March 8, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28281454/immune-stimulatory-effects-of-neutrophil-extracellular-traps-in-granulomatosis-with-polyangiitis
#19
Christina Lange, Elena Csernok, Frank Moosig, Julia U Holle
OBJECTIVES: The aim of this study was to analyse the role of netting neutrophils in the pathogenesis of granulomatosis with polyangiitis (GPA), especially their interplay with peripheral blood mononuclear cells (PBMCs). METHODS: The amount of cell-free DNA (cfDNA) was determined in sera from GPA patients (pairs active/inactive state of disease, n=18) and from healthy controls (HCs, n=10). Furthermore, we performed in vitro incubation experiments using PBMCs and NETs from patients and HCs for accessing the effect of NETs on PBMC behaviour...
March 8, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28281452/three-year-trajectories-of-disability-and-fatigue-in-systemic-sclerosis-a-cohort-study
#20
Linda M Willems, Linda Kwakkenbos, Madelon C Vonk, Frank H J van den Hoogen, Theodora P M Vliet Vlieland, Cornelia H M van den Ende
OBJECTIVES: Functional disability and fatigue are important consequences of systemic sclerosis (SSc), but little is known about their course over time. The aim of this study was to identify and characterise homogeneous subgroups with distinct 3-year trajectories of disability and fatigue, separately. METHODS: A 3-year cohort study including 215 patients with SSc was conducted. Functional disability was assessed using the Health Assessment Questionnaire-Disability Index (HAQ-DI)...
March 8, 2017: Clinical and Experimental Rheumatology
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