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Clinical and Experimental Rheumatology

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https://www.readbyqxmd.com/read/29352854/fc-gamma-receptor-binding-profile-of-anti-citrullinated-protein-antibodies-in-immune-complexes-suggests-a-role-for-fc%C3%AE-ri-in-the-pathogenesis-of-synovial-inflammation
#1
Ayla C Kempers, M Reza Nejadnik, Yoann Rombouts, Andreea Ioan-Facsinay, Maikel van Oosterhout, Wim Jiskoot, Tom W J Huizinga, René E M Toes, Hans Ulrich Scherer
OBJECTIVES: Anti-citrullinated protein antibodies (ACPA) are highly specific for rheumatoid arthritis (RA). Here, we studied binding of ACPA-IgG immune complexes (IC) to individual Fc gamma receptors (FcγR) to identify potential effector mechanisms by which ACPA could contribute to RA pathogenesis. METHODS: ACPA-IgG1 and control IgG1(IgG1 depleted of ACPA-IgG1) were isolated from plasma and synovial fluid (SF) of RA patients by affinity chromatography using CCP2 peptides...
January 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29352853/interferon-regulatory-factor-5-is-a-potential-target-of-autoimmune-response-triggered-by-epstein-barr-virus-and-mycobacterium-avium-subsp-paratuberculosis-in-rheumatoid-arthritis-investigating-a-mechanism-of-molecular-mimicry
#2
Marco Bo, Gian Luca Erre, Magdalena Niegowska, Marco Piras, Loredana Taras, Maria Giovanna Longu, Giuseppe Passiu, Leonardo A Sechi
OBJECTIVES: Rheumatoid arthritis (RA) is a chronic disease characterised by a pro-inflammatory cytokines linked erosive joint damage and by humoral and cellular response against a broad range of self-peptides. Molecular mimicry between Epstein-Barr virus (EBV), Mycobacterium avium subsp. paratuberculosis (MAP) and host peptides has long been regarded as an RA pathogenetic mechanism. Using bioinformatic analysis we identified high sequence homology among interferon regulatory factor 5 (IRF5), EBV antigen BOLF1 and MAP antigen MAP_4027...
January 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29352852/associations-between-the-slc22a12-gene-and-gout-susceptibility-a-meta-analysis
#3
Yao Zou, Jinfeng Du, Yantong Zhu, Xi Xie, Jinwei Chen, Guanghui Ling
OBJECTIVES: The aim of this study is to explore whether the polymorphisms of rs475688 and rs3825016 in the solute carrier family 22 member 12 (SLC22A12) gene are associated with the susceptibility to gout or hyperuricaemia. METHODS: Relevant studies were enrolled by searching databases systematically. The pooled odds ratios (ORs) with 95% confidence interval (CI) were used to evaluate the associations. Q-test and I2 statistics were used to evaluate the heterogeneity...
January 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29352848/association-between-perceived-level-of-stress-clinical-characteristics-and-psychopathological-symptoms-in-women-with-systemic-lupus-erythematosus
#4
María Isabel Peralta-Ramírez, José Manuel Pérez-Mármol, Margarita Castañeda-Cabestany, Ana María Santos-Ruiz, Eva Montero-López, José Luís Callejas-Rubio, Nuria Navarrete-Navarrete, José Carlos Fernández-Sánchez, Juan Francisco Jiménez-Alonso, Norberto Ortego-Centeno, José Mario Sabio, Marta García-Morales
OBJECTIVES: To evaluate psychopathological status and stress level from a sample with SLE; compare mental functioning and stress levels between women with SLE and healthy women; determine whether disease duration, disease activity, cumulative organ damage and stress have an influence on psychopathological symptoms in SLE patients; and evaluate whether perception of stress is related to SLE severity. METHODS: We conducted a cross-sectional study of 425 participants; 202 women with SLE, with an average age (SD) of 36...
January 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29352847/switching-to-biosimilar-infliximab-real-world-data-in-patients-with-severe-inflammatory-arthritis
#5
Christopher R Holroyd, Lucy M Parker, Sarah Bennett, Jalaa Zarroug, Caron Underhill, Brian Davidson, Ray Armstrong, Nicholas C Harvey, Elaine Dennison, Cyrus Cooper, Christopher J Edwards
No abstract text is available yet for this article.
January 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29352846/the-janus-kinase-inhibitor-tofacitinib-inhibits-tnf-%C3%AE-induced-gliostatin-expression-in-rheumatoid-fibroblast-like-synoviocytes
#6
Yohei Kawaguchi, Yuko Waguri-Nagaya, Naoe Tatematsu, Yusuke Oguri, Masaaki Kobayashi, Masahiro Nozaki, Kiyofumi Asai, Mineyoshi Aoyama, Takanobu Otsuka
OBJECTIVES: Gliostatin (GLS) is known to have angiogenic and arthritogenic activity, and GLS expression levels in serum from patients with rheumatoid arthritis (RA) are significantly correlated with the disease activity. Tofacitinib is a novel oral Janus kinase (JAK) inhibitor and is effective in treating RA. However, the mechanism of action of tofacitinib in fibroblast-like synoviocytes (FLSs) has not been elucidated. The purpose of this study was to investigate the modulatory effects of tofacitinib on serum GLS levels in patients with RA and GLS production in FLSs derived from patients with RA...
January 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29352844/hypoalbuminaemia-in-antineutrophil-cytoplasmic-antibody-associated-vasculitis-incidence-and-significance
#7
Peng-Cheng Xu, Zhi-Ying Tong, Tong Chen, Shan Gao, Shui-Yi Hu, Xiao-Wei Yang, Tie-Kun Yan, Shan Lin
OBJECTIVES: Hypoalbuminaemia has been proved to be a biomarker of poor prognosis in many diseases. The objective of this study was to investigate the significance of hypoalbuminaemia in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). METHODS: Data of 117 AAV patients were analysed retrospectively. The relationship between hypoalbuminaemia and disease severity were studied. The influence of albumin on the pathogenetic role of ANCA was investigated in vitro...
January 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29352843/tocilizumab-after-a-first-line-with-anti-tnf-in-rheumatoid-arthritis-a-cost-consequence-analysis-in-the-italian-setting
#8
Sergio Iannazzo, Maurizio Benucci, Ennio Giulio Favalli
OBJECTIVES: Switching to a different mechanism of action in rheumatoid arthritis (RA) patients after a first anti-TNF-α has proved to be effective. The objective of this study was a health economic assessment in Italy. METHODS: The study was conducted using a pharmacoeconomic model with a 3-year time horizon. Effectiveness was measured as days gained in low disease activity (LDA; DAS28-ESR <3.2) or in remission (DAS28-ESR <2.6). The model simulated the response to treatments, based on the Rotation Or Change (ROC) trial, the probability of discontinuation and switch to a 3rd-line biologic, and the transition to death...
January 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29352842/amylin-in-the-insulin-resistance-of-patients-with-rheumatoid-arthritis
#9
Ivan Ferraz-Amaro, Raquel López-Mejias, Beatriz Tejera-Segura, Antonia M de Vera-González, Begoña Ubilla, Jose M Olmos, José Luis Hernández, Miguel Angel González-Gay
OBJECTIVES: Amylin, which is co-secreted with insulin, plays a role in glycemic regulation and is impaired in type 2 diabetes. In the present study we assess, for the first time, the implication of amylin in the development of insulin resistance (IR) in rheumatoid arthritis (RA). METHODS: This was a cross-sectional study involving 361 non-diabetic individuals, 151 patients with RA and 210 sex-matched controls. Insulin, C-peptide, amylin, lipoprotein serum concentrations, and IR indexes by homeostatic model assessment (HOMA2) were evaluated in patients and controls...
January 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29352841/predict-rheumatoid-arthritis-conversion-from-undifferentiated-arthritis-with-dynamic-contrast-enhanced-mri-and-laboratory-indexes
#10
Xinwei Lei, Huixia Li, Ying Zhan, Jin Qu
OBJECTIVES: To investigate the clinical value of dynamic contrast-enhanced MRI (DCE-MRI) and laboratory indexes in predicting conversion from undifferentiated arthritis (UA) to rheumatoid arthritis (RA). METHODS: A total 81 DMARD-naive UA patients were studied. 37 cases were ultimately diagnosed as RA, 32 cases were diagnosed as other types of arthritis, and the remaining cases were still UA during the 1-year follow-up. The DCE-MRI and laboratory measures were fed into a logistic regression analysis...
January 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29352840/serum-aminoacyl-trna-synthetase-interacting-multifunctional-protein-1-aimp1-a-novel-disease-activity-predictive-biomarker-of-systemic-lupus-erythematosus
#11
Sung Soo Ahn, Shin Hee Hong, Younhee Park, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee, Sang Gyu Park
OBJECTIVES: Secreted aminoacyl-tRNA synthetase-interacting multifunctional protein-1 (AIMP1) has been reported to have pro-inflammatory properties. The aim of this study was to evaluate the clinical significance of serum AIMP1 in patients with systemic lupus erythematosus (SLE). METHODS: Serum levels of AIMP1 were measured in 160 patients with SLE using a human AIMP1 ELISA kit. Eighty patients were classified as active SLE (SLEDAI-2K ≥ 5), and 80 patients were classified as stable SLE...
January 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29352839/the-new-frontier-of-imaging-the-micron
#12
Giacomo Aringhieri, Saverio Vitali, Piercarlo Rossi, Davide Caramella
No abstract text is available yet for this article.
January 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29352838/reduction-or-cessation-of-antiviral-agents-in-hepatitis-b-virus-carriers-treated-with-biologic-agents
#13
Byeongzu Ghang, Danbi Lee, Inseok Hwang, Chang-Keun Lee, Bin Yoo, Yong-Gil Kim
No abstract text is available yet for this article.
January 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29352851/prostate-cancer-associated-polyarteritis-nodosa-improvement-of-clinical-manifestations-after-prostatectomy
#14
Toshiyuki Watanabe, Masatoshi Kanda, Keisuke Kikuchi
No abstract text is available yet for this article.
January 11, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29352850/ultrasound-to-detect-involvement-of-vertebral-artery-in-giant-cell-arteritis
#15
Martin Gehlen, Nikolaus Schaefer, Michael Schwarz-Eywill, A Maier
No abstract text is available yet for this article.
January 11, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29352849/impact-of-vasculitis-on-employment-and-income
#16
Lillian Barra, Renée L Borchin, Cristina Burroughs, George C Casey, Carol A McAlear, Antoine G Sreih, Kalen Young, Peter A Merkel, Christian Pagnoux
OBJECTIVES: Work disability associated with rheumatic diseases accounts for a substantial financial burden. However, few studies have investigated disability among patients with vasculitis. The purpose of this study was to examine the impact of vasculitis on patient employment and income. METHODS: Patients enrolled in the Vasculitis Clinical Research Consortium (VCRC) Patient Contact Registry, living in the USA or Canada, and followed for >1 year post-diagnosis, participated in an online survey-based study...
January 10, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29352845/rapidly-progressive-glomerulonephritis-caused-by-overlap-syndrome-of-igg4-related-tubulointerstitial-nephritis-and-myeloperoxidase-antineutrophil-cytoplasmic-antibody-associated-necrotising-glomerulonephritis
#17
Toshiyuki Watanabe, Masatoshi Kanda, Shinji Fukaya, Yayoi Ogawa, Kazumasa Akikawa
No abstract text is available yet for this article.
January 10, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29303702/comparison-of-the-risks-of-hospitalisation-for-cardiovascular-events-in-patients-with-rheumatoid-arthritis-treated-with-tocilizumab-and-etanercept
#18
Elena Generali, Greta Carrara, Carlo Selmi, Suzanne M M Verstappen, Antonella Zambon, Alessandra Bortoluzzi, Ettore Silvagni, Carlo Alberto Scirè
OBJECTIVES: To verify if tocilizumab (TCZ) is associated with an increased risk of cardiovascular (CV) events compared with etanercept (ETN) in rheumatoid arthritis (RA). METHODS: This is a retrospective cohort study on administrative healthcare databases (AHD) in Italy. Patients were identified using a validated algorithm based on AHD. Exposure to specific drugs was estimated by the drug prescription recorded in the AHD. The occurrence of acute CV events (myocardial infarction, stroke, other CV events) was derived from the hospital discharge forms...
December 28, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29303705/pneumonia-in-children-with-juvenile-idiopathic-arthritis-in-finland-1999-2014-a-nationwide-retrospective-register-linkage-study
#19
Päivi H Salonen, Hanna Säilä, Juha H Salonen, Miika Linna, Mika Helminen, Markku J Kauppi
OBJECTIVES: To compare the incidence of pneumonia in children with juvenile idiopathic arthritis (JIA) to the aged-matched general population and to evaluate the use of anti-rheumatic medication among children with JIA and pneumonia. METHODS: The National Hospital Discharge Register collects data on ICD-diagnoses of hospital patients in Finland. From this register, patients with JIA under 18 years of age with pneumonia from 1999 through 2014 were identified. The control group consisted of age-matched patients derived from the general population with a diagnosis of pneumonia made in the same calendar year as the pneumonia of the JIA patients...
December 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29303701/increased-levels-of-serum-histone-h4-and-activated-protein-c-in-patients-with-active-rheumatoid-arthritis
#20
Wanchan Peng, Xianghui Liang, Yong Zhong, Yaou Zhou, Litao Hu, Wei Wang
OBJECTIVES: We aimed to examine the levels of serum H4 and activated protein C (APC) in rheumatoid arthritis (RA) and other autoimmune conditions, and investigate the associations between H4 or APC levels and disease activity indicators in RA. METHODS: Serum H4 and APC distribution was examined in samples from patients with RA, systemic lupus erythematosus (SLE), polymyositis (PM), and ankylosing spondylitis (AS), as well as in samples from healthy controls, using commercial ELISA kits...
December 27, 2017: Clinical and Experimental Rheumatology
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