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Clinical and Experimental Rheumatology

Allan Gibofsky, Martha Skup, Min Yang, Manish Mittal, Dendy Macaulay, Arijit Ganguli
OBJECTIVES: To estimate short-term costs associated with non-medical switch (NMS) from originator biologics to biosimilars among stable patients with autoimmune conditions in rheumatology, gastroenterology, and dermatology from a US provider's and third-party payer's perspective. METHODS: An economic model was constructed to estimate switching costs related to physician time and healthcare resource utilisation (HRU) at the initial NMS visit and over 3 months. The proportion of patients with relevant conditions treated with originators and expected NMS rate, physician time, HRU, and payer reimbursement were derived from a physician survey...
June 25, 2018: Clinical and Experimental Rheumatology
Dan Xu, Xiaoyu Liu, Chengyang Lu, Jing Luo, Caihong Wang, Chong Gao, Jianfang Xie, Xiaofeng Li
OBJECTIVES: Little is known about the roles of peripheral immune cell subsets in synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome. Up to now, just a few studies have focused on this issue. We aimed to analyse the distribution and phenotype of T cell subsets and natural killer (NK) cells in the peripheral blood of patients with SAPHO syndrome. METHODS: The proportion and absolute counts of circulating immune cells were assessed in 19 patients diagnosed as SAPHO syndrome and 19 healthy controls...
June 25, 2018: Clinical and Experimental Rheumatology
Harini Bagavant, Micah L Dunkleberger, Nina Wolska, Magdalena Sroka, Astrid Rasmussen, Indra Adrianto, Courtney Montgomery, Kathy Sivils, Joel M Guthridge, Judith A James, Joan T Merrill, Umesh S Deshmukh
OBJECTIVES: Microbial infections and mucosal dysbiosis influence morbidity in patients with systemic lupus erythematosus (SLE). In the oral cavity, periodontal bacteria and subgingival plaque dysbiosis provide persistent inflammatory stimuli at the mucosal surface. This study was undertaken to evaluate whether exposure to periodontal bacteria influences disease parameters in SLE patients. METHODS: Circulating antibodies to specific periodontal bacteria have been used as surrogate markers to determine an ongoing bacterial burden, or as indicators of past exposure to the bacteria...
June 25, 2018: Clinical and Experimental Rheumatology
Giulia Di Benedetto, Laurence Lempereur, Domenico Valle, Emanuela Greco, Renato Bernardini, Andrea Lenzi, Silvia Migliaccio
OBJECTIVES: The aim of our study was to investigate possible interaction of IL-17, TRAIL, and TNF-α in the modulation of osteoblast homeostasis in vitro, using human differentiated osteoblastic Saos-2 cells as in vitro model. METHODS: The effects of these cytokines on osteoblastic cell viability were assessed, by MTT assay, alone or in combination, at different times and concentrations. The effects of IL-17 and TNF-α on the regulatory system of osteoclast activity RANK/RANKL/ OPG were evaluated by Western blot and ELISA techniques in cell culture media...
June 25, 2018: Clinical and Experimental Rheumatology
Valerie Aloush, Iris Dotan, Jacob Nadav Ablin, Ori Elkayam
OBJECTIVES: The presence of serological markers associated with inflammatory bowel disease (IBD) has been studied in spondyloarthritis with conflicting results. The anti-glycan antibodies: anti-laminaribioside, anti-chitobioside, and anti-mannobioside carbohydrate antibodies (ALCA, ACCA, and AMCA) are serological markers previously associated with IBD. We aim to investigate the prevalence of these antibodies in spondyloarthritis in comparison with rheumatoid arthritis (RA) patients. METHODS: Serum samples were obtained from consecutive patients with spondyloarthritis and were compared to RA and healthy controls...
June 25, 2018: Clinical and Experimental Rheumatology
Athanasios G Tzioufas, Andreas V Goules
No abstract text is available yet for this article.
June 21, 2018: Clinical and Experimental Rheumatology
Farhad Shahram, Abdolhadi Nadji, Massoomeh Akhlaghi, Seyyedeh Tahereh Faezi, Cheyda Chams-Davatchi, Hormoz Shams, S Zahra Ghodsi, Fereydoun Davatchi
OBJECTIVES: This study proposed to report the characteristics of paediatric Behçet's disease (PED-BD) in a cohort of patients from Iran's registry and compare them with different reports throughout the world. METHODS: From a cohort of 7504 Iranian patients with Behçet's disease those diagnosed before the age of 16 years were included in this study. Data were collected on a standard protocol comprising 105 items, including demographic features, type of presentation, and different clinical and laboratory findings...
June 19, 2018: Clinical and Experimental Rheumatology
Andrea Picchianti Diamanti, Luca Navarini, Filippo Messina, Milica Markovic, Luisa Arcarese, Fabio Basta, Giorgia Meneguzzi, Paolo Emanuele Domenico Margiotta, Bruno Laganà, Antonella Afeltra, Raffaele D'Amelio, Annamaria Iagnocco
OBJECTIVES: The ability of ultrasound (US) to identify subclinical joint inflammation in rheumatoid arthritis (RA) patients in remission has been already reported. Nonetheless, current studies present a lack of homogeneity in patient's characteristics and number of joints assessed by US. The aim of this study was to identify a reduced set of target joints to be scanned in RA patients in clinical remission in order to detect subclinical synovitis. METHODS: Forty RA patients in clinical remission (DAS28 ≤2...
June 14, 2018: Clinical and Experimental Rheumatology
Cristina Macía-Villa, Sandra Falcao, Marwin Gutierrez, Julio Medina, Hilde Berner Hammer, Eugenio De Miguel
OBJECTIVES: To evaluate by ultrasound (US) the frequency and reliability of peritenon extensor tendon inflammation (PTI) and intra articular synovitis (IAS) in metacarpophalangeal joints (MCPj) of psoriatic arthritis (PsA) patients. METHODS: 27 PsA patients with clinical involvement of MCPj were consecutively included. Presence of PTI and IAS were evaluated by grey-scale (GS) and power Doppler (PD). Longitudinal and transverse 3-5 second videos of US examinations were recorded for reliability assessments by five readers...
June 14, 2018: Clinical and Experimental Rheumatology
Eydis E Runarsdottir, Anna I Gunnarsdottir, Thorvardur J Love, Petur S Gunnarsson, Bjorn Gudbjornsson
OBJECTIVES: To identify the proportion of patients with psoriatic arthritis (PsA) who would meet inclusion criteria of the randomised clinical trials that were performed leading up to registration of the tumour necrosis factor inhibitors (TNFi). METHODS: Data from 329 patients with PsA were obtained from an Icelandic database, ICEBIO, medical records at the University Hospital of Iceland, and the private out-patient clinic Laeknasetrid Ltd. The patients were classified according to whether they met the inclusion criteria of the clinical trials that were performed ahead of the registration of each respective TNFi...
June 14, 2018: Clinical and Experimental Rheumatology
Jie Pan, Ling Lei, Cheng Zhao
OBJECTIVES: Although the efficacy of combined treatment targeting pulmonary arterial hypertension (PAH) has been suggested to be preferable, the comparative efficacy of combination therapy versus monotherapy in connective tissue disease (CTD)-associated PAH (CTD-PAH) remains undetermined. We performed a meta-analysis regarding this topic. METHODS: The Cochrane Library, MEDLINE, PubMed, and EMBASE databases were searched for randomised controlled trials (RCTs) that directly compared the efficacies of combination therapy and monotherapy targeting PAH in patients with CTD-PAH...
June 14, 2018: Clinical and Experimental Rheumatology
Dong-Jin Park, Ji-Hyoun Kang, Kyung-Eun Lee, Sang-Cheol Bae, Won Tae Chung, Jung-Yoon Choe, Sang-Youn Jung, Yun-Sung Kim, Hye-Soon Lee, Jennifer Lee, Yeon-Ah Lee, Sung-Hwan Park, Yune-Jung Park, Chang-Hee Suh, Dae-Hyun Yoo, Shin-Seok Lee
OBJECTIVES: Recent studies have shown that a combination treatment of mycophenolate mofetil (MMF) and tacrolimus (TAC) may be an option for lupus nephritis (LN) patients that do not adequately respond to initial treatment. We evaluated the efficacy and safety of the combination treatment of MMF and TAC in LN patients with suboptimal response to prior MMF or TAC treatments. METHODS: In this multicentre study, we retrospectively enrolled 62 patients with class III, IV, or V LN who inadequately responded to MMF or TAC treatment...
June 14, 2018: Clinical and Experimental Rheumatology
Sami Bahlas, Laila Damiati, Nadia Dandachi, Hesham Sait, Maha Alsefri, Peter N Pushparaj
OBJECTIVES: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease of unknown etiology, characterised by symmetric erosive synovitis, leading inevitably to the destruction of cartilage and bone as well as bursa and tendon sheaths of joints. Our aim of this study was to decipher the differential expression of cytokines, chemokines and growth factors in the plasma of RA patients with active disease, using magnetic bead-based Luminex Multiple Analyte Profiling (xMAP) technology, for precision medicine...
June 14, 2018: Clinical and Experimental Rheumatology
Yujia Yang, Feng Yan, Liyun Wang, Xi Xiang, Yuanjiao Tang, Qiu Li, Lv Xiaoyan
OBJECTIVES: To assess the diagnostic value of shear wave elastography (SWE) quantification in patients with systemic sclerosis (SSc) and healthy controls. METHODS: Skin elastic modulus (E) values and thicknesses were measured at 6 skin sites between the SSc (n=37) and control (n=37) groups. Thickness and E values were converted into T- and E-scores, to allow skin thickness and stiffness of different regions to be quantified based on a single standard. T- and E-scores were compared with the modified Rodnan skin score (mRSS)...
June 11, 2018: Clinical and Experimental Rheumatology
Banu Kara Kivanc, Emel Gönüllü, Olga Meltem Akay, Adem Ertürk, Cengiz Bal, Döndü Üskudar Cansu, Cengiz Korkmaz
OBJECTIVES: To investigate whether there is a difference between male and female patients with Behçet's disease (BD) in terms of hypercoagulability by using modified rotational thromboelastograhic (ROTEM) analysis. METHODS: 126 BD patients (71 male, 55 female; mean age: 41±9 yrs) who met ISSG criteria for BD were included into the study. 23 patients with vasculitis (16 female, 7 male; mean age 49±16 yrs), and 25 healthy individuals (11 female, 14 male; mean age: 37±10 yrs) were included to the study as disease and healthy control (HC) group, respectively...
June 8, 2018: Clinical and Experimental Rheumatology
Julia Goossens, Baptiste Coustet, Elisabeth Palazzo, Philippe Dieudé, Sébastien Ottaviani
OBJECTIVES: Body mass index (BMI) might affect rheumatoid arthritis (RA) outcomes. Clinical assessment of swollen joint count (SJC) might also be affected by obesity in terms of obesity-related excess adipose tissue. In this study, we compared ultrasonography (US) and clinical examination in assessing the effect of BMI on RA disease activity assessment. METHODS: This was a single-centre study including RA (ACR/EULAR criteria) patients. US assessment was performed by one trained rheumatologist blinded to clinical data...
June 7, 2018: Clinical and Experimental Rheumatology
Hongbo Xiao, Ning Wei, Meiling Su, Zuying Xiong
OBJECTIVES: The aim of this study was to explore the value of serum miRNA for evaluating renal tissue activity in patients with class IV lupus nephritis (LN). METHODS: First, we used a microRNA array to identify miRNAs differentially expressed between class IV LN patients and healthy volunteers (n=4/group). Then, we analysed the association between these identified miRNAs and renal tissue activity in class IV LN patients. Finally, to validate the results, 20 class IV LN patients (confirmed by renal biopsy) and 20 healthy control volunteers were further studied...
June 7, 2018: Clinical and Experimental Rheumatology
Ruethairat Apipattarakul, Chingching Foocharoen, Sittichai Netwijitpan, Ajanee Mahakkanukrauh, Siraphop Suwannaroj, Panita Limpawattana, Ratanavadee Nanagara
OBJECTIVES: To identify the clinical differences and mortality rate between adult and elderly onset systemic sclerosis (SSc). METHODS: We conducted a historical cohort study of SSc patients during January 2007-December 2011. The SSc patients were 60 and over classified as elderly onset SSc. Cox regression analysis was used to estimate the probability of survival and for assessing the factors associated with mortality. RESULTS: The medical records of 350 SSc patients were reviewed; 53 (15...
June 7, 2018: Clinical and Experimental Rheumatology
Kirsi Paalanen, Katja Rannio, Tuomas Rannio, Juha Asikainen, Pekka Hannonen, Tuulikki Sokka
OBJECTIVES: To investigate the 10-year clinical course of patients with seronegative arthritis with the emphasis of reclassification of diagnoses when applicable. METHODS: A total of 1030 patients including 435 seronegative cases were classified as early RA in 1997-2005 at Jyväskylä Rheumatology Centre and prospectively scheduled for a ten-year follow-up. Clinical data from the follow-up visits and the case-reports until and including the 10-year visit or death, whichever happened earlier, were retrospectively collected and reviewed with re-classification of the cases when applicable...
June 7, 2018: Clinical and Experimental Rheumatology
Toshiyuki Watanabe, Toshiyuki Hattori, Yayoi Ogawa, Satoshi Jodo
No abstract text is available yet for this article.
June 7, 2018: Clinical and Experimental Rheumatology
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