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Clinical and Experimental Rheumatology

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https://www.readbyqxmd.com/read/28770704/undifferentiated-connective-tissue-disease-predictors-of-evolution-into-definite-disease
#1
María García-González, Beatriz Rodríguez-Lozano, Sagrario Bustabad, Ivan Ferraz-Amaro
OBJECTIVES: The natural evolution of undifferentiated connective tissue diseases (UCTD) has not yet been established. The aim of our study was to analyse the clinical outcomes of a cohort of UCTD patients followed in a routine outpatient setting and to establish which clinical, serological or capillaroscopy features are associated with an increased risk of evolution to definite connective tissue disease (CTD). METHODS: Data for this study were collected by a retrospective review of 758 patients referred to our hospital, between 1999 and 2008, with suspected CTD...
August 2, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28770712/two-year-retention-rate-of-golimumab-in-rheumatoid-arthritis-psoriatic-arthritis-and-ankylosing-spondylitis-data-from-the-lorhen-registry
#2
Maria Manara, Roberto Caporali, Ennio G Favalli, Vittorio Grosso, Fabiola Atzeni, Piercarlo Sarzi Puttini, Roberto Gorla, Chiara Bazzani, Enrico Fusaro, Raffaele Pellerito, Pier Andrea Rocchetta, Luigi Sinigaglia
OBJECTIVES: We aimed to provide data on golimumab real-life use in rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) from a multicentre observational registry of Northern Italy. METHODS: We extracted data of patients who started treatment with golimumab from October 2010, and who had at least one follow-up visit. Data were analysed until a maximum follow-up of 24 months. The two-year retention rate in the three diseases was assessed with Kaplan-Meier estimators...
July 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28770702/prevalence-of-anti-dfs70-antibodies-in-patients-with-and-without-systemic-autoimmune-rheumatic-diseases
#3
Ora Shovman, Boris Gilburd, Chen Chayat, Howard Amital, Pnina Langevitz, Abdulla Watad, Adi Guy, Dolores Perez, Danielle Azoulay, Miri Blank, Yael Segal, Chelsea Bentow, Michael Mahler, Yehuda Shoenfeld
OBJECTIVES: Autoantibodies to the dense fine speckled 70 (DFS70) antigen are common among antinuclear antibodies (ANA) positive healthy individuals (HI). We assessed the prevalence of anti-DFS70 antibodies in patients with and without ANA-associated rheumatic diseases (AARDs) by two methods: chemiluminescent immunoassay (CIA) and an indirect immunofluorescence (IIF) assay based on immunoadsorption for DFS70. METHODS: Fifty-one ANA-positive sera samples from patients with confirmed clinical diagnosis of AARD, 92 samples from HI and 85 samples submitted to a reference laboratory for routine ANA testing were evaluated for the presence of anti-DFS70 antibodies...
July 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28770709/timing-of-onset-affects-arthritis-presentation-pattern-in-antisyntethase-syndrome
#4
Miguel A González-Gay, Carlomaurizio Montecucco, Albert Selva-O'Callaghan, Ernesto Trallero-Araguas, Ovynd Molberg, Helena Andersson, Jorge Rojas-Serrano, Diana Isabel Perez-Roman, Jutta Bauhammer, Christoph Fiehn, Rossella Neri, Simone Barsotti, Hannes M Lorenz, Andrea Doria, Anna Ghirardello, Florenzo Iannone, Margherita Giannini, Franco Franceschini, Ilaria Cavazzana, Konstantinos Triantafyllias, Maurizio Benucci, Maria Infantino, Mariangela Manfredi, Fabrizio Conti, Andreas Schwarting, Giandomenico Sebastiani, Annamaria Iuliano, Giacomo Emmi, Elena Silvestri, Marcello Govoni, Carlo Alberto Scirè, Federica Furini, Francisco Javier Lopez-Longo, Julia Martínez-Barrio, Marco Sebastiani, Andreina Manfredi, Javier Bachiller-Corral, Walter Alberto Sifuentes Giraldo, Marco A Cimmino, Claudio Cosso, Alessandro Belotti Masserini, Giovanni Cagnotto, Veronica Codullo, Mariaeva Romano, Giuseppe Paolazzi, Raffaele Pellerito, Lesley Ann Saketkoo, Norberto Ortego-Centeno, Luca Quartuccio, Alberto Batticciotto, Elena Bartoloni Bocci, Roberto Gerli, Christof Specker, Elena Bravi, Carlo Selmi, Simone Parisi, Fausto Salaffi, Federica Meloni, Enrico Marchioni, Alberto Pesci, Giulia Dei, Marco Confalonieri, Paola Tomietto, Laura Nuno, Francesco Bonella, Nicolò Pipitone, Antonio Mera-Valera, Nair Perez-Gomez, Simone Gerzeli, Raquel Lopez-Mejias, Carlo Jorge Matos-Costa, Jose Antonio Pereira da Silva, José Cifrian, Claudia Alpini, Ignazio Olivieri, María Ángeles Blázquez Cañamero, Ana Belén Rodriguez Cambrón, Santos Castañeda, Lorenzo Cavagna
OBJECTIVES: To evaluate if the timing of appearance with respect to disease onset may influence the arthritis presentation pattern in antisynthetase syndrome (ASSD). METHODS: The patients were selected from a retrospective large international cohort of ASSD patients regularly followed-up in centres referring to AENEAS collaborative group. Patients were eligible if they had an antisynthetase antibody testing positive in at least two determinations along with arthritis occurring either at ASSD onset (Group 1) or during the course of the disease (Group 2)...
July 26, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28770706/efficacy-of-belimumab-for-the-long-term-maintenance-therapy-of-thrombocytopenia-in-systemic-lupus-erythematosus
#5
Ginevra De Marchi, Luca Quartuccio, Milena Bond, Salvatore De Vita
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July 26, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28770705/are-the-cutaneous-manifestations-in-patients-with-primary-antiphospholipid-syndrome-a-marker-for-predicting-lung-manifestations
#6
Milica Kontic, Ljudmila Stojanovich, Milena Mijailović-Ivković, Mladen Velinović, Jasminka Srnka, Marija Zdravkovic
OBJECTIVES: The aim of this study was to investigate association between pulmonary and skin manifestations in a large group of patients with primary antiphospholipid syndrome (PAPS) as well as their connection with antiphospholipid antibodies. METHODS: Our prospective study comprises of 390 patients with primary APS. Antiphospholipid antibody (aPL) analysis included detection of aCL (IgG/IgM), ß2GPI (IgG/IgM) and LA. Distinct pulmonary and skin associations were determined, as well as their associations with aPL...
July 17, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28770711/chinese-lupus-treatment-and-research-group-cstar-registry-x-family-history-in-relation-to-lupus-clinical-and-immunological-manifestations
#7
Xiaomei Leng, Mengtao Li, Xiangpei Li, Xiao Zhang, Shengyun Liu, Lijun Wu, Li Ma, Liqi Bi, Xiaoxia Zuo, Lingyun Sun, Cibo Huang, Jiuliang Zhao, Yan Zhao, Xiaofeng Zeng
OBJECTIVES: This study aimed to examine the associations between family history and clinical manifestations and immunologic characteristics of lupus in China. METHODS: Based on their family history, lupus patients from the Chinese lupus treatment and research group (CSTAR) registry were categorised: familial lupus (FL), family history of other rheumatic disorders (RD), and sporadic lupus (SL). Demographic data, clinical manifestations, and laboratory data were compared among these three groups...
July 7, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28770710/olfactory-dysfunction-and-autoimmunity-pathogenesis-and-new-insights
#8
REVIEW
Oded Shamriz, Yehuda Shoenfeld
Olfaction plays an important role in the perception of our environment. Smell impairment is known to be a manifestation of several autoimmune diseases. Similarities between the olfactory and immune systems and previously published human studies and animal models of autoimmune diseases account for the accumulating evidence for this observation. In this review, we will present the current literature concerning olfactory dysfunction in autoimmune diseases, discuss clinical aspects and provide new insights regarding pathogenesis and possible mechanisms...
July 7, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28770708/the-interaction-between-anti-ro-ssa-and-anti-la-ssb-autoantibodies-and-anti-infectious-antibodies-in-a-wide-spectrum-of-auto-immune-diseases-another-angle-of-the-autoimmune-mosaic
#9
Nancy Agmon-Levin, Amir Dagan, Yogev Peri, Juan-Manuel Anaya, Carlo Selmi, Angela Tincani, Nicola Bizzaro, Ljudmila Stojanovich, Jan Damoiseaux, Jan Willem Cohen Tervaert, Marta Mosca, Ricard Cervera, Yehuda Shoenfeld
OBJECTIVES: The presence of anti-Ro/SSA and anti-La/SSB antibodies has been linked with autoimmunity in general and with several autoimmune diseases (AID) in particular. In the current study we evaluated these antibodies in a wide spectrum of AID as well as the links between them and anti-infectious antibodies. METHODS: We examined 2082 sera from patients with 16 different AID compared to 524 sera from geographically-matched healthy controls, for the presence and titres of anti-Ro/SSA and anti-La/SSB...
July 6, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28770707/pro-fibrotic-effect-of-il-6-via-aortic-adventitial-fibroblasts-indicates-il-6-as-a-treatment-target-in-takayasu-arteritis
#10
Xiufang Kong, Lili Ma, Zongfei Ji, Zhihui Dong, Zhigang Zhang, Jun Hou, Si Zhang, Lingying Ma, Lindi Jiang
OBJECTIVES: This study aimed to clarify potential mechanism of IL-6 involved in adventitial fibrosis via adventitial fibroblast in Takayasu arteritis (TAK). METHODS: Immunohistochemistry and double-labelled immunofluorescence were performed on vascular tissue from patients with TAK and controls. Human aorta adventitial fibroblast (AAF) was cultured and stimulated with interleukine 6 (IL-6)/IL-6 receptor (IL-6R). Real-time PCR, western blot, enzyme-linked immunosorbent assays, chromatin immunoprecipitation (ChIP) and reporter assay were conducted in vitro experiments to determine effect of IL-6/IL-6R on AAF...
July 6, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28770703/serum-levels-of-igg-antibodies-against-alpha-enolase-are-increased-in-patients-with-beh%C3%A3-et-s-disease-and-are-associated-with-the-severity-of-oral-ulcer-erythrocyte-sedimentation-rates-and-c-reactive-protein
#11
Shin Eui Kang, Sang Jin Lee, Joo Youn Lee, Hyun Jung Yoo, Jin Kyun Park, Eun Young Lee, Eun Bong Lee, Young Wook Song
OBJECTIVES: Behçet's disease (BD) is a chronic inflammatory disease of unknown etiology, characterised by recurrent oral and genital ulcers, skin lesions, uveitis, and arthritis. It is regarded as vasculitis and anti-endothelial cell antibodies (AECA) are found in patients with BD. One of the endothelial cell antibodies was reported to recognise alpha-enolase. This study aimed to investigate expression of alpha-enolase in the surface of peripheral blood cells and serum anti-alpha-enolase antibody (AEA), and their association with clinical manifestations or disease activity of BD...
July 6, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28664836/the-use-of-hand-perfusion-scintigraphy-to-assess-raynaud-s-phenomenon-associated-with-hand-arm-vibration-syndrome
#12
Kyung-Ann Lee, Hyung Woo Chung, Sang-Heon Lee, Hae-Rim Kim
OBJECTIVES: This study aimed to evaluate the hand perfusion scintigraphic features of hand-arm vibration syndrome (HAVS) and to compare these with the features of primary and secondary Raynaud's phenomenon (RP) associated with systemic sclerosis (SSc). METHODS: Hand perfusion scintigraphy was performed in 57 patients with primary RP, 71 patients with HAVS-related RP, and 15 patients with SSc-related RP. We calculated 6 ratios: chilled to ambient hand and wrist ratios of the first peak height, initial slope, and blood pool uptake...
June 30, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28664835/prevalence-and-significance-of-anti-saccharomyces-cerevisiae-antibodies-in-primary-sj%C3%A3-gren-s-syndrome
#13
Alessia Alunno, Onelia Bistoni, Francesco Carubbi, Valentina Valentini, Giacomo Cafaro, Elena Bartoloni Bocci, Roberto Giacomelli, Roberto Gerli
OBJECTIVES: Saccharomyces cerevisiae is a common yeast used in the food industry. IgG and IgA antibodies against the phosphopeptidomannan of the S. cerevisiae cell wall (ASCA) are a well known marker of disease severity in Crohn's disease. Moreover, a number of studies assessed ASCA in several systemic and organ-specific autoimmune diseases postulating molecular mimicry as a possible link between ASCA and autoimmunity. However, since they have never been tested in primary Sjögren's syndrome (pSS), the purpose of this study was to investigate these antibodies in a large cohort of pSS patients, compared to healthy donors (HD), and their significance as potentially helpful biomarker in a clinical setting...
June 29, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28664834/design-of-a-randomised-placebo-controlled-clinical-trial-of-nintedanib-in-patients-with-systemic-sclerosis-associated-interstitial-lung-disease-senscis%C3%A2
#14
Oliver Distler, Kevin K Brown, Jörg H W Distler, Shervin Assassi, Toby M Maher, Vincent Cottin, John Varga, Carl Coeck, Martina Gahlemann, Wiebke Sauter, Hendrik Schmidt, Kristin B Highland
OBJECTIVES: Nintedanib is a tyrosine kinase inhibitor approved for the treatment of idiopathic pulmonary fibrosis (IPF). The pathological pathways involved in fibrogenesis in IPF and interstitial lung disease associated with systemic sclerosis (SSc-ILD) show commonalities; both involve fibroblast activation, myofibroblast accumulation and deposition of extracellular matrix. The SENSCIS™ trial is a randomised, placebo-controlled Phase III trial that will evaluate the efficacy and safety of nintedanib in patients with SSc-ILD (NCT02597933)...
June 29, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28664831/opioid-use-in-patients-with-polymyalgia-rheumatica
#15
Michael D Richter, Sara J Achenbach, Jorge A Zamora-Legoff, Cynthia S Crowson, Eric L Matteson
OBJECTIVES: To examine the trends of chronic opioid use in patients with polymyalgia rheumatica (PMR) over an 11-year period in Olmsted County, Minnesota, USA and compare use to subjects without the disease. METHODS: Retrospective data on opioid prescriptions were collected from 2005 to 2015 in a population-based incidence cohort of patients meeting the 2012 American College of Rheumatology classification criteria for PMR alongside comparison subjects. Poisson regression methods were used to compare opioid use between these groups...
June 29, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28664830/genome-wide-expression-and-methylation-profiling-reveal-candidate-genes-in-osteoarthritis
#16
Yu Fan, Jun Chen, Yuemei Yang, Jin Lin, Zhihong Wu
OBJECTIVES: Osteoarthritis (OA) is a common degenerative disease of the synovial joints. Although numerous studies have been performed, the aetiology of OA remains unclear. Evidence suggests that DNA methylation plays important roles in OA. METHODS: Integrated analysis of five gene expression and one methylation profilings in OA was performed to identify differentially expressed genes (DEGs) and differentially methylated genes (DMGs), respectively. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment were then conducted to reveal the biological functions of DEGs and DMGs...
June 29, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28664833/significance-of-pentraxin-3-in-patients-with-juvenile-scleroderma
#17
Amra Adrovic, Sezgin Sahin, Kenan Barut, Sinem Durmus, Hafize Uzun, Ozgur Kasapcopur
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June 20, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28664832/clinical-determinants-of-elevated-systolic-pulmonary-artery-pressure-measured-by-transthoracic-doppler-echocardiography-in-early-systemic-sclerosis
#18
Patricia E Carreira, Loreto Carmona, Beatriz E Joven, Estibaliz Loza, Jose Luis Andreu, Gabriela Riemekasten, Serena Vettori, Yannick Allanore, Alexandra Balbir-Gurman, Paolo Airò, Ulrich A Walker, Nemanja Damjanov, Lidia P Ananieva, Simona Rednic, László Czirják, Oliver Distler, Dominique Farge, Roger Hesselstrand, Ada Corrado, Paola Caramaschi, Mohammed Tikly, Marco Matucci-Cerinic
OBJECTIVES: To explore the prevalence and clinical associations of elevated systolic pulmonary artery pressure (sPAP), measured by Transthoracic Doppler-echocardiography (TTE) in patients with early systemic sclerosis (SSc). METHODS: A cross-sectional analysis of the prospective EULAR Scleroderma Trial and Research (EUSTAR) database was performed. SSc patients with <3 years from the first non-Raynaud's phenomenon (RP) symptom at baseline EUSTAR visit, were selected...
June 20, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28628471/haematological-involvement-associated-with-a-mild-autoinflammatory-phenotype-in-two-patients-carrying-the-e250k-mutation-of-pstpip1
#19
Elena Belelli, Chiara Passarelli, Manuela Pardeo, Dirk Holzinger, Fabrizio De Benedetti, Antonella Insalaco
OBJECTIVES: Hyperzincaemia/hypercalprotectinemia (Hz/Hc) syndrome is a recently described condition caused by a specific de novo mutation (E250K) affecting PSTPIP1 gene. It has a phenotype distinct from classical pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome that includes severe systemic and cutaneous inflammation, hepatosplenomegaly, arthritis without sequelae, pancytopenia and failure to thrive. METHODS: We describe an 8-year-old boy who presented recurrent right knee swelling mimicking septic arthritis and persistent bone marrow involvement, without cutaneous involvement...
June 19, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28628466/evaluation-of-cancer-associated-myositis-and-scleroderma-autoantibodies-in-breast-cancer-patients-without-rheumatic-disease
#20
Ami A Shah, Antony Rosen, Laura K Hummers, Betty J May, Alpana Kaushiva, Richard B S Roden, Deborah K Armstrong, Fredrick M Wigley, Livia Casciola-Rosen, Kala Visvanathan
OBJECTIVES: Systemic sclerosis (scleroderma) and dermatomyositis are two prototypic autoimmune diseases that are strongly associated with malignancy. While specific autoantibodies in these diseases are markers of an increased risk of cancer at scleroderma and dermatomyositis onset, it is not known whether these autoantibodies are biomarkers of cancer risk in patients without rheumatic disease. METHODS: In a matched case-control study of women without rheumatic disease, identified from a familial breast cancer cohort, 50 breast cancer cases and 50 controls were assayed for 3 autoantibodies that are known markers of cancer-associated scleroderma and dermatomyositis: anti-RNA polymerase III, anti-NXP2, and anti-TIF1γ...
June 19, 2017: Clinical and Experimental Rheumatology
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