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Clinical and Experimental Rheumatology

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https://www.readbyqxmd.com/read/29787366/parasympathetic-activity-increases-with-digital-microvascular-damage-and-vascular-endothelial-growth-factor-in-systemic-sclerosis
#1
Antonietta Gigante, Domenico Margiotta, Luca Navarini, Marta Liberatori, Biagio Barbano, Luigi Tubani, Antonella Afeltra, Edoardo Rosato
OBJECTIVES: The imbalance between angiogenic and angiostatic factors with derangement of the microvasculature are hallmarks of systemic sclerosis (SSc). Raynaud's phenomenon in SSc probably is due to the impaired neuroendothelial control mechanisms between vasoconstriction and vasodilatation. The aim of this study is to evaluate autonomic nervous system function using heart rate variability (HRV) analysis and to correlate with vascular endothelial growth factor (VEGF). METHODS: Twenty-seven SSc patients were enrolled...
May 11, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29745886/primary-myelofibrosis-but-not-autoimmune-myelofibrosis-accompanied-by-sj%C3%A3-gren-s-syndrome-and-primary-biliary-cirrhosis-in-a-patient-with-trisomy-8-mosaic-a-case-report-and-literature-review
#2
Chenyang Lu, Xiaoyan Wu, Hongyan Wen, Huiying Gao, Caihong Wang, Bo Yang, Zhipeng Liang, Chong Gao, Xiaofeng Li
Bone marrow fibrosis has been found to be associated with autoimmune disorders, and autoimmune myelofibrosis (AIMF) has been defined. Primary myelofibrosis (PMF), a clonal myeloproliferative disorder, should be distinguished from AIMF which has a good response to steroids, as the former has a high mortality and very bad response to conventional treatment. This case report describes a rare case of PMF accompanied with Sjögren's syndrome (SJS) and primary biliary cirrhosis (PBC), in a patient with trisomy 8 mosaic...
May 10, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29745880/the-role-of-auditory-evoked-potentials-and-otoacoustic-emissions-in-early-detection-of-hearing-abnormalities-in-beh%C3%A3-et-s-disease-patients-a-case-control-study
#3
Doa W Nada, Radwa M El Khouly, Souzan E Gadow, Shymaa A Hablas, Marwa A Aboelhawa, Doaa S Al Ashkar, Amal M El Barbary, Manal S Hussein, Elsayed Rageh, Alaa M Elsalawy, Mohamed H Abo-Zaid, Samah Elshweikh, Amani M El Gharib
OBJECTIVES: To determine the types and to assess the role of auditory evoked potentials and otoacoustic emissions in early detection of hearing abnormalities in Behçet's disease (BD) patients. Their correlations with disease activity were also considered. METHODS: Thirty patients with BD and thirty apparently sex- and age-matched healthy volunteers were included in this study. Auditory evaluation included pure tone audiometry (PTA), otoacoustic emissions (TEOAEs, DPOAE), auditory brainstem response test (ABR) and cortical auditory evoked potentials (tone and speech CAEPs) for all patients and control...
May 10, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29745893/cell-therapies-for-refractory-rheumatoid-arthritis
#4
REVIEW
Rui Liu, Pengfei Zhao, Wenfeng Tan, Miaojia Zhang
Rheumatoid arthritis (RA), an autoimmune disease, is characterised by a persistent synovitis in the joints and systemic inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids and disease-modifying antirheumatic drugs (DMARDs) are widely used to treat RA patients. However, a portion of patients still have inadequate response to traditional medications. Recently, cell-based therapies have become the focus, attracting more attention due to their potential for remission induction. Several immune-regulatory cell types, such as haematopoietic stem cells, mesenchymal stem cells and regulatory T cells have been defined as novel targets...
May 8, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29745892/peripheral-cd4-cd28null-t-cells-as-predictors-of-damage-in-systemic-lupus-erythematosus-patients
#5
Manuel F Ugarte-Gil, César Sánchez-Zúñiga, Rocio V Gamboa-Cardenas, Madeley Aliaga-Zamudio, Francisco Zevallos, Ana Mosqueira-Riveros, Mariela Medina-Chinchón, Giannina Tineo-Pozo, Claudia Elera-Fitzcarrald, Victor Pimentel-Quiroz, Omar Sarmiento-Velasquez, Cristina Reátegui-Sokolova, Jorge M Cucho-Venegas, José Alfaro-Lozano, Zoila Rodriguez-Bellido, César Pastor-Asurza, Graciela S Alarcón, Risto Perich-Campos
OBJECTIVES: To determine whether the CD4+CD28null T-cells subpopulation predicts the occurrence of damage in SLE. METHODS: This longitudinal study was conducted in consecutive SLE patients seen every six months in our Rheumatology Department since 2012. Patients in whom CD4+CD28null T-cells had been measured and who had at least one subsequent visit were included in the study. Survival analyses (univariable and multivariable Cox-regression models) were performed to determine the risk of overall and domain damage (as per the SLICC Damage Index - SDI) as a function of the frequency of this T-cell subpopulation...
May 8, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29745890/pattern-of-muscle-involvement-in-inclusion-body-myositis-a-sonographic-study
#6
Jemima Albayda, Lisa Christopher-Stine, Clifton O Bingham Iii, Julie J Paik, Eleni Tiniakou, Seth Billings, O Manny Uy, Philippe Burlina
OBJECTIVES: Imaging plays a role in myositis assessment by detecting muscle changes indicative of pathology. This study was conducted to determine the ultrasonographic pattern of muscle involvement in patients with inclusion body myositis (IBM) through an assessment of muscle echointensity. METHODS: Sixty-two individuals were consecutively studied, 18 with IBM, 16 with polymyositis or dermatomyositis and 28 normal controls. Standardised scans were completed bilaterally for the deltoids, biceps, flexor digitorum profundus (FDP), flexor carpi ulnaris, rectus femoris, tibialis anterior and gastrocnemius assessing for muscle echointensity changes...
May 8, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29745887/successful-treatment-of-a-patient-with-both-systemic-lupus-erythematosus-and-progressive-hepatitis-c-using-immunosuppressive-therapy-and-interferon-beta
#7
Yusuke Sugimori, Hiroyuki Yamashita, Hideki Yorifuji, Yuko Takahashi, Hiroshi Kaneko, Akio Mimori
No abstract text is available yet for this article.
May 8, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29745885/explorative-analyses-of-protein-biomarkers-in-patients-with-early-rheumatoid-arthritis-achieving-sustained-drug-free-remission-after-treatment-with-tocilizumab-or-methotrexate-based-strategies-from-transcriptomics-to-proteomics
#8
Xavier M Teitsma, Johannes W G Jacobs, Arno N Concepcion, Attila Pethö-Schramm, Michelle E A Borm, Jacob M van Laar, Johannes W J Bijlsma, Floris P J G Lafeber
OBJECTIVES: Previously, we identified networks of co-expressed genes related to achieving sustained drug-free remission (sDFR). The aim of the present exploratory analysis was to identify inflammatory proteins associated with achieving sDFR and their enriched biological pathways, and compare these pathways with those found in the previous transcriptomic analyses. METHODS: Serum samples were used from 60 patients who participated in the U-Act-Early trial and were treated-to-target with tocilizumab plus methotrexate, or tocilizumab or methotrexate; 37 achieved sDFR (≥3 months drug-free) and 23 did not (controls)...
May 8, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29745884/type-iv-collagen-metabolism-is-associated-with-disease-activity-radiographic-progression-and-response-to-tocilizumab-in-rheumatoid-arthritis
#9
Natasja Stæhr Gudmann, Peter Junker, Pernille Juhl, Christian Schneider Thudium, Anne Sofie Siebuhr, Inger Byrjalsen, Morten Asser Karsdal, Anne Christine Bay-Jensen
OBJECTIVES: The expanding spectrum of targeted therapies for rheumatoid arthritis (RA) implies a need for development of precision tools for disease assessment reflecting pathobiologic processes. Type IV collagen is an abundant protein of basement membranes, but is also present in the intercellular matrix of the synovial lining layer. We aimed to investigate the association of type IV collagen turnover with RA disease activity, response to IL-6 inhibition and radiographic progression...
May 8, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29745883/prevalence-and-characteristics-associated-with-dactylitis-in-patients-with-early-spondyloarthritis-results-from-the-esperanza-cohort
#10
Maria Isabel Tévar-Sánchez, Victoria Navarro-Compán, Juan J Aznar, Luis F Linares, Maria C Castro, Eugenio De Miguel
OBJECTIVES: Dactylitis is a typical feature of psoriatic arthritis. However, dactylitis was included as a spondyloarthritis (SpA) feature for both (axial and peripheral) of the ASAS classification criteria, but data about its prevalence are scarce, especially in patients with a recent onset of the disease. Our objective was to determine the prevalence and characteristics associated with dactylitis in patients with early SpA. METHODS: A baseline dataset from the ESPeranza cohort was used...
May 8, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29745878/should-over-treatment-of-axial-spondyloarthritis-with-biologics-remain-a-concern-after-the-issue-of-the-new-asas-criteria-data-from-regisponserbio-spanish-register-of-biological-therapy-in-spondyloarthritides
#11
Mireia Moreno, Jordi Gratacós, Victoria Navarro-Compán, Eugenio de Miguel, Pilar Font, Teresa Clavaguera, Luis Francisco Linares, Beatriz Joven, Xavier Juanola
OBJECTIVES: To study whether disease status at treatment initiation has changed after the issue of the ASAS classification criteria. METHODS: REGISPONSERBIO registers patients with axial spondyloarthritis (axSpA) on biological treatment since 2013. It includes patients starting biological treatment (incident) or already on biological therapies (prevalent). Patients in both groups were compared in terms of: age at disease onset and at treatment start, disease duration, gender, HLA-B27, body mass index (BMI), BASDAI, BASFI, C-reactive protein, ESR, metrological data, ASQoL, WAPAI, extra-articular manifestations, comorbidities, radiological study, type of biological treatment and concomitant treatments...
May 8, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29745875/interstitial-lung-disease-in-patients-with-mixed-connective-tissue-disease-pilot-study-on-predictors-of-lung-involvement
#12
Neha Narula, Tathagat Narula, Isabel Mira-Avendano, Benjamin Wang, Andy Abril
OBJECTIVES: Mixed connective tissue disease (MCTD) is an immune-mediated systemic disorder characterised by serum autoantibodies against U1-ribonucleoprotein and diverse multisystemic clinical manifestations. Approximately 50% of patients with MCTD develop a radiologic pattern of interstitial lung disease (ILD). Our single centre, cross-sectional study sought to identify clinical and serologic associations of ILD in patients with MCTD which may serve as predictors of lung disease and prognosis...
May 8, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29745874/strong-correlation-between-cancer-progression-and-anti-transcription-intermediary-factor-1%C3%AE-antibodies-in-dermatomyositis-patients
#13
Mariko Ogawa-Momohara, Yoshinao Muro, Teruyuki Mitsuma, Masao Katayama, Koichi Yanaba, Mizuho Nara, Masao Kakeda, Michihiro Kono, Masashi Akiyama
OBJECTIVES: Transcription intermediary factor 1γ (ΤΙF1γ) protein is known as a tumour suppressor that promotes cellular differentiation. Autoantibodies to ΤΙF1γ have a strong clinical association with cancers associated with dermatomyositis (DM). This study aims to identify the clinical characteristics of cancers in anti-ΤΙF1γ antibody-positive adult patients with DM. METHODS: This retrospective analysis covered 160 adult DM patients who visited Nagoya University Hospital or collaborating medical centres between 2003 and 2016...
May 8, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29745876/the-presence-of-staphylococcal-superantigens-in-nasal-swabs-and-correlation-with-activity-of-granulomatosis-with-polyangiitis-in-own-material
#14
Justyna Fijołek, Elzbieta Wiatr, Violetta Petroniec, Ewa Augustynowicz-Kopec, Michal Bednarek, Dariusz Gawryluk, Magdalena Maria Martusewicz-Boros, Katarzyna Modrzewska, Elzbieta Radzikowska, Kazimerz Roszkowski-Sliz
OBJECTIVES: Nasal carriage of Staphylococcus aureus and its superantigens (SAg) seem to be a risk factor disease exacerbation in granulomatosis with polyangiitis (GPA). We investigated the association between the presence of SAg in nasal swabs and activity of disease in GPA patients also taking into account correlation with an antimicrobial treatment. METHODS: In a prospective study of a total of 150 GPA patients hospitalised in the period 2009-2016, nasal swabs were examined for the presence of Staphylococcus aureus and SAg...
May 4, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29745872/effects-of-autonomic-dysfunction-on-exercise-tolerance-in-systemic-sclerosis-patients-without-clinical-and-instrumental-evidence-of-cardiac-and-pulmonary-involvement
#15
Marcello Di Paolo, Antonietta Gigante, Marta Liberatori, Liborio Sardo, Paolo Marinelli, Marco Rossetti, Paolo Palange, Luigi Tubani, Edoardo Rosato
OBJECTIVES: Autonomic dysfunction (AD) in systemic sclerosis (SSc) was already confirmed through heart rate variability (HRV) analysis. Cardio-pulmonary exercise testing (CPET) is a useful tool in early detection of exercise tolerance in SSc patients. Aim of the study was to assess the relationships existing between AD and exercise tolerance. METHODS: Thirty-two [4 M, 28 F; median age: 47.5 (20-65) years] consecutive SSc patients were enrolled. All patients underwent pulmonary function testing, incremental symptom-limited CPET and twenty-four hours ECG Holter recording with HRV analysis in time and frequency domain...
May 4, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29745882/the-adenosinergic-system-a-potential-player-in-the-pathogenesis-of-anca-associated-vasculitis
#16
REVIEW
Lovis Kling, Bernhard K Krämer, Benito A Yard, Anna-Isabelle Kälsch
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a potentially lethal autoimmune disease whose pathology comprises disturbed T cell differentiation and functionality accompanied by dysfunctional autoreactive immunoglobulin development, culminating in destructive innate immune response as well. Purines, adenine nucleotides and adenosine in particular, have been elucidated as potent extracellular mediators for fine adjustment of these pivotal processes establishing human immunity. Therefore, the extracellular purinergic microenvironment is under control of ectonucleotidases CD39 and CD73 degrading pro-inflammatory adenosine triphosphate (ATP) to anti-inflammatory adenosine as well as adenosine deaminase bound to CD26 deactivating adenosine...
May 3, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29745881/catastrophic-multiple-arterial-dissections-revealing-concomitant-polyarteritis-nodosa-and-vascular-elhers-danlos-syndrome
#17
Léo Caudrelier, Grégory Pugnet, Léonardo Astudillo, Xavier Delbrel, Alessandra Bura Riviere, Laurent Sailler
No abstract text is available yet for this article.
May 3, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29745871/venous-thrombosis-and-relapses-in-patients-with-beh%C3%A3-et-s-disease-descriptive-analysis-from-spanish-network-of-beh%C3%A3-et-s-disease-regeb-cohort
#18
Monica Rodríguez-Carballeira, Roser Solans, Jose Ramon Larrañaga, Francisco Javier García-Hernández, Raquel Rios-Fernández, Javier Nieto, Xavier Solanich, Ferran Martínez-Valle, Eva Fonseca, Francisco Jose Muñoz, Guadalupe Fraile, Begoña de Escalante, Rafael Boldova, Robert Hurtado, Gerard Espinosa
OBJECTIVES: To describe the characteristics of patients with Behçet's disease (BD) who presented with venous thrombosis. In addition, we identified the factors associated with this venous involvement and those related with recurrent venous thrombosis. METHODS: Up to January 2015, 544 BD patients from 20 Spanish hospitals had been included in the REGEB (REGistro de la Enfermedad de Behçet as Spanish nomenclature). We selected those patients who presented venous thrombosis...
May 3, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29745889/potentially-traumatic-events-ptsd-and-post-traumatic-stress-spectrum-in-patients-with-fibromyalgia
#19
Ciro Conversano, Claudia Carmassi, Carlo A Bertelloni, Laura Marchi, Tommaso Micheloni, Manuel G Carbone, Giovanni Pagni, Claudia Tagliarini, Gabriele Massimetti, Laura M Bazzichi, Liliana Dell'Osso
OBJECTIVES: Fibromyalgia (FM) is defined as a severe, chronic, non-articular rheumatic condition characterised by widespread musculoskeletal pain, hyperalgesia and generalised tender points, in the absence of inflammatory or structural musculoskeletal abnormalities. Pain is the predominant symptom, allodynia and hyperalgesia are common signs. Extreme fatigue, impaired cognition and non-restorative sleeping difficulties coexist in addition to other somatic symptoms. Several studies suggest there is a meaningful relationship between FM and the psychological symptoms of depression and post-traumatic stress disorder (PTSD)...
April 24, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29745888/survival-of-connective-tissue-disease-associated-pulmonary-arterial-hypertension
#20
Ana Paula Luppino Assad, Francisca Gavilanes Oleas, Jose Leonidas Alves, Caio Julio Cesar Dos Santos Fernandes, Percival Degrava Sampaio-Barros, Rogerio Souza
No abstract text is available yet for this article.
April 19, 2018: Clinical and Experimental Rheumatology
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