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Clinical and Experimental Rheumatology

Eduardo F Santos, Catia M Duarte, Ricardo O Ferreira, Ana M Pinto, Rinie Geenen, José P da Silva
OBJECTIVES: Depressive symptoms are common among patients with rheumatoid arthritis (RA). This study was aimed at developing a multifactorial explanatory model that evaluated the influence of personality traits, disease activity, perceived disease impact, and comorbidities. METHODS: This cross-sectional study used structural equation modelling estimation to analyse the associations between these dimensions, pursuing three hypotheses. Depressive symptoms were assessed using the Hospital Anxiety and Depression Scale, disease impact by the Rheumatoid Arthritis Impact of Disease score, personality by the Ten Item Personality Inventory and the disease activity through the Disease Activity Score 28 joints...
November 12, 2018: Clinical and Experimental Rheumatology
Jacob R Stever, Grant W Cannon, Chia-Chen Teng, Neil A Accortt, David H Collier, Brian C Sauer
OBJECTIVES: To examine factors associated with major therapeutic changes (MTC) among US Veterans with moderate/severe rheumatoid arthritis (RA) based on Disease Activity Score based on 28 joints (DAS28). METHODS: We used data from patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry from 1/1/2006 through 12/31/2014. The index date was a clinic visit with DAS28 >3.2 (moderate/severe disease) following an 18-month pre-index period that included ≥2 DAS28 measurements ≥60 days apart...
November 12, 2018: Clinical and Experimental Rheumatology
Abdulsamet Erden, Ezgi Deniz Batu, Alper Sarı, Hafize Emine Sönmez, Berkan Armagan, Selcan Demir, Esra Fırat, Yelda Bilginer, Sule Apras Bilgen, Ömer Karadağ, Umut Kalyoncu, Sedat Kiraz, Ihsan Ertenli, Seza Özen, Ali Akdogan
OBJECTIVES: Colchicine is the main therapy for familial Mediterranean fever (FMF); however, 5-10% of patients are colchicine-resistant. There is no standard and validated definition for colchicine resistance. We aimed to compare the existing definitions for colchicine resistance in both adult and paediatric FMF patients to find out the best definition to determine colchicine-resistant patients. METHODS: 385 FMF patients were evaluated and patients receiving anti-interleukin-1 treatment were included...
November 12, 2018: Clinical and Experimental Rheumatology
Panagiota Karagianni, Adrianos Nezos, Foteini Ioakeim, Athanasios G Tzioufas, Haralampos M Moutsopoulos
OBJECTIVES: Autoinflammatory diseases are characterised by abnormal hyperactivity of the innate immune system, causing systemic inflammation. The cryopyrin associated periodic syndrome (CAPS), the hyper IgD syndrome (HIDS) and the TNF receptor-associated periodic syndrome (TRAPS), are autoinflammatory conditions associated with mutations in the NLRP3, MVK and TNFRSF1A genes, respectively. We present the experience of our Department with these rare syndromes analysing genetic and clinical data of adult patients encountered between January 2011 and September 2017...
November 9, 2018: Clinical and Experimental Rheumatology
Elizabeth Olivares-Martínez, Diego F Hernández-Ramírez, Carlos A Núñez-Álvarez, Luis Llorente, Gabriela Hernandez-Molina
OBJECTIVES: Although anti-cyclic citrullinated peptides antibodies are specific markers for rheumatoid arthritis (RA), they might be present in other diseases. Our aim was to assess the native or citrullinated antigens recognised by patients with primary Sjögren's syndrome (pSS) and to evaluate their association with clinical and serological features. METHODS: In an initial screening, we assessed the serum reactivity of 12 patients with pSS against native or in vitro citrullinated antigens of HEp-2 cells by immunoblotting...
November 8, 2018: Clinical and Experimental Rheumatology
Santos Castañeda, Sara Remuzgo-Martínez, Raquel López-Mejías, Fernanda Genre, Jaime Calvo-Alén, Irene Llorente, Elena Aurrecoechea, Ana M Ortiz, Ana Triguero, Ricardo Blanco, Javier Llorca, Miguel A González-Gay
OBJECTIVES: In patients with rheumatoid arthritis (RA), insulin resistance (IR), a component of the metabolic syndrome, is closely linked to the systemic inflammation induced by proinflammatory cytokines such as tumor necrosis factor-α and interleukin (IL)-6. In the present study, we aimed to assess if an intravenous administration of the anti-IL-6 receptor tocilizumab may yield a rapid improvement of IR in RA. METHODS: 50 consecutive non-diabetic patients with RA refractory to methotrexate, undergoing periodic treatment with tocilizumab, were studied...
November 7, 2018: Clinical and Experimental Rheumatology
Caroline B McCulley, Jennifer L Barton, Grant W Cannon, Brian C Sauer, Chia Chen Teng, Michael D George, Liron Caplan, Bryant R England, Ted R Mikuls, Joshua F Baker
OBJECTIVES: Obese patients with rheumatoid arthritis (RA) may be more likely to discontinue therapy than non-obese patients, possibly signifying a more refractory phenotype. The purpose of this study was to examine the association between body mass index (BMI) and discontinuation rates for different RA treatments accounting for confounding factors. METHODS: Veterans Affairs administrative databases were used to define initial courses of methotrexate (MTX), hydroxychloroquine, sulfasalazine, prednisone, and self-injectable tumour necrosis factor inhibitors (TNFi)...
November 7, 2018: Clinical and Experimental Rheumatology
Joachim Høg Mortensen, Xiang Guo, Melissa De Los Reyes, Morten Hanefeld Dziegiel, Morten Asser Karsdal, Anne Christine Bay-Jensen, Wendy I White
OBJECTIVES: Macrophages possess widespread pro-inflammatory, destructive, and remodelling capabilities that can critically contribute to acute and chronic diseases, such as rheumatoid arthritis (RA). Continuous monitoring and measurement of selective counteraction of macrophage activity in patients require a sensitivity and non-invasive marker. We characterised the VICM (citrullinated and MMP degraded vimentin fragment) biomarker by investigating the release from in vitro activated macrophages and by monitoring the change in serum levels after treatment with the anti-GM-CSFRα-mAb (mavrilimumab)...
November 7, 2018: Clinical and Experimental Rheumatology
Xue Li, Jingling Sun, Rong Mu, Yuzhou Gan, Guanying Wang, Jing He, Li Yi, Qingwen Wang, Xiaolin Sun, Zhanguo Li
OBJECTIVES: To identify specific cerebrospinal fluid (CSF) biomarkers for the diagnosis and disease severity evaluation of neuropsychiatric systemic lupus erythematosus (NPSLE). METHODS: Patients presented with neuropsychiatric symptoms were recruited and categorised as 36 NPSLE, 19 SLE controls, 4 other connective tissue disease (CTD) controls and 10 nervous system disorder (NSD) controls. The NPSLE group consisted of severe NPSLE (sNPSLE) and mild NPSLE (mNPSLE)...
November 7, 2018: Clinical and Experimental Rheumatology
Emre Ozer, Demet Seker, Emir Taner, Amra Adrovic, Sezgin Sahin, Kenan Barut, Ozgur Kasapcopur
OBJECTIVES: The aim of this study is to evaluate the frequency of juvenile spondyloarthropathies (JSpA) in childhood familial Mediterranean fever (FMF) patients from a single tertiary centre. Additionally, we aimed to investigate the main clinical characteristics of FMF patients with coexistence of JSpA clinical features. METHODS: We evaluated 323 paediatric FMF patients who were followed at our clinic. All of the patients were evaluated by three different investigators (EO, DS, ET) for the presence of JSpA clinical signs, according to the recently proposed JSpA criteria...
November 5, 2018: Clinical and Experimental Rheumatology
Esperanza Naredo, Iolanda Maria Rutigliano, Iustina Janta, Chiara Scirocco, Lara Valor, Fabiana Figus, Luis Carreño, Jesús Garrido, Annamaria Iagnocco
OBJECTIVES: To compare colour Doppler (CD) versus power Doppler (PD) semiquantitative and quantitative scoring of synovial vascularisation and to evaluate the relationship between semiquantitative and quantitative scores in patients with rheumatoid arthritis (RA). METHODS: One hundred RA patients underwent B-mode, PD, and CD assessments of 12 joints at two European centres. Each joint with synovial hypertrophy (SH) detected on B-mode was semiquantitatively scored (0-3) for PD (SPD score) and CD (SCD score) synovial signal...
November 5, 2018: Clinical and Experimental Rheumatology
Anica Nötzel, Kay-Geert Hermann, Eugen Feist, Claudia Kedor, Katharina Ziegeler, Andrea Stroux, Jürgen Mews, Michael Schnorfeil, Bernd Hamm, Torsten Diekhoff
OBJECTIVES: To validate the diagnostic benefit of dual-energy computed tomography (DECT) and synovial fluid aspiration in suspected gout. METHODS: A total of 43 patients with suspected gout underwent aspiration and DECT (320-row CT; Canon Medical Systems, Japan). The patients were assessed (gout vs. non-gout) based on the 2015 ACR/EULAR gout classification criteria using clinical and laboratory findings. The results were analysed by comparing two scenarios using McNemar test: Scenario A: ACR/EULAR criteria, followed by DECT results and aspiration findings...
November 5, 2018: Clinical and Experimental Rheumatology
Hafize Emine Sönmez, Berkan Armağan, Gizem Ayan, Kenan Barut, Ezgi Deniz Batu, Abdulsamet Erden, Serdal Uğurlu, Yelda Bilginer, Özgur Kasapçopur, Ömer Karadağ, Sule Apras Bilgen, Huri Özdoğan, Seza Ozen
OBJECTIVES: Polyarteritis nodosa is a necrotising vasculitis of predominantly medium size vessels. The present study aimed to summarise the characteristics of PAN patients, and also analyse the trend of decreasing PAN frequency in the last 25 years. METHODS: PAN patients followed up between 1990 and 2015 were included. The demographics, clinical findings and outcomes were retrospectively evaluated. RESULTS: One hundred thirty-three patients, including 66 children, were enrolled in the study...
October 30, 2018: Clinical and Experimental Rheumatology
Mustafa Yassin, Amir Oron, Dror Robinson
OBJECTIVES: Low back pain (LBP) occurs in many patients with fibromyalgia (FM). The current study aimed to assess the possible pain and function amelioration associated with medical cannabis therapy (MCT) in this setting. METHODS: 31 patients were involved in an observational cross-over study. The patients were screened, treated with 3 months of standardised analgesic therapy (SAT): 5 mg of oxycodone hydrochloride equivalent to 4.5 mg oxycodone and 2.5 mg naloxone hydrochloride twice a day and duloxetine 30 mg once a day...
October 30, 2018: Clinical and Experimental Rheumatology
Angelo Fassio, Davide Gatti, Maurizio Rossini, Luca Idolazzi, Alessandro Giollo, Giovanni Adami, Paolo Gisondi, Giampiero Girolomoni, Ombretta Viapiana
OBJECTIVES: Interleukin-17 (IL-17) is an important cytokine involved in the pathogenesis of bone lesions of psoriatic arthritis (PsA). The aim of our study was to explore the short-term effects (≤6 months) of secukinumab (an anti-IL-17 antibody) on the serum levels of bone turnover markers (BTMs) and on the inhibitors of the WNT signalling pathway. METHODS: The study sample consisted of patients with PsA starting treatment with secukinumab 150 mg every month, and healthy controls (HCs)...
October 23, 2018: Clinical and Experimental Rheumatology
Lin Cheng, Long Qian, Zhou-Zhou Xu, Yue Tan, Chao-Yin Luo
OBJECTIVES: Epidemiology shows that smoking plays a central role in rheumatoid arthritis (RA). The aim of this study was to evaluate the potential relationship between smoking, aromatic hydrocarbon receptor (AHR) and RA susceptibility. METHODS: We performed a hospital-based, case-control study of patients with RA and healthy controls. Expressions of AHR, cytochrome P4501A1(CYP1A1), aromatic hydrocarbon receptor repressor (AHRR) genes were assessed in peripheral blood mononuclear cells (PBMCs) and cultured cells using real-time PCR...
October 22, 2018: Clinical and Experimental Rheumatology
Fausto Salaffi, Marco Di Carlo, Silvia Arcà, Mauro Galeazzi
OBJECTVES: To establish the cut-off points for disease severity states of two self-administered questionnaires (the revised version of the Fibromyalgia-Impact Questionnaire [FIQR] and the Fibromyalgia Assessment Status [FAS]) designed for the evaluation of multidimensional aspects of fibromyalgia (FM). METHODS: In this cross-sectional study, consecutive FM patients completed both FIQR and FAS. The external criterion for grading disease severity was the item one of the Short Form-36 Health Survey (SF-36)...
October 16, 2018: Clinical and Experimental Rheumatology
Alessia Alunno, Lidia Ibba-Manneschi, Onelia Bistoni, Sabrina Cipriani, Fabiana Topini, Roberto Gerli, Mirko Manetti
OBJECTIVES: The mechanisms underlying increased cardiovascular risk in primary Sjögren's syndrome (pSS) remain unclear. Since the recently discovered angiogenic T cells (Tang) may participate in endothelial repair by cooperating with endothelial progenitor cells (EPC), we aimed at quantifying and characterising Tang in the peripheral blood and minor salivary glands (MSG) of pSS patients. METHODS: Tang (CD3+CD31+CXCR4+) and EPC (CD34+CD133+VEGFR-2+) were quantified by flow cytometry in peripheral blood samples from 36 pSS patients and 20 healthy donors...
October 15, 2018: Clinical and Experimental Rheumatology
Sang-Won Lee, Do Young Kim, Sang Hoon Ahn, Yong-Beom Park, Kwang-Hyub Han, Jun Yong Park
OBJECTIVES: We evaluated the laboratory and radiological data on liver and investigate liver fibrosis induced by hepatic manifestation of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) using the aspartate aminotransferase to platelet ratio index (APRI) and an index of fibrosis (FIB-4) in 136 immunosuppressive drug-naïve patients. METHODS: We retrospectively reviewed the medical records of 136 patients with AAV without chronic liver diseases or autoimmune diseases...
October 11, 2018: Clinical and Experimental Rheumatology
Garifallia Sakellariou, Giovanni Lombardi, Barbara Vitolo, Marta Gomarasca, Martina Faraldi, Roberto Caporali, Giuseppe Banfi, Carlomaurizio Montecucco
OBJECTIVES: We aimed to evaluate the correlation between serum calprotectin and clinical and ultrasonographic (US) variables in early-onset psoriatic arthritis (PsA) and controls with rheumatoid arthritis (RA). METHODS: In a retrospective cross-sectional study, including PsA and matched RA patients, 44 joint counts (TJC, SJC), calprotectin, ESR and CRP were measured. US of wrists and MCPs 1-5 was performed, with grey-scale (GS) and power Doppler (PD) scored 0-3 at each site, summed in a total score...
October 8, 2018: Clinical and Experimental Rheumatology
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