journal
MENU ▼
Read by QxMD icon Read
search

Pharmacological Research: the Official Journal of the Italian Pharmacological Society

journal
https://www.readbyqxmd.com/read/30016644/activities-bioavailability-and-metabolism-of-lipids-from-structural-membranes-and-oils-promising-research-on-mild-cognitive-impairment
#1
REVIEW
Antonio Pérez-Gálvez, Manuel Jarén-Galán, Juan Garrido-Fernández, M Visitacion Calvo, Francesco Visioli, Javier Fontecha
Concomitant with increased lifespan, large segments of the population are experiencing cognitive decline, which might progress to Alzheimer's disease (AD). Currently, there is no cure for AD and, once the neurodegenerative disorders are established, patients use pharmacologic therapy to slow the progression of the symptoms and require appropriate care to manage their condition. The preclinical stage of neural degeneration that progress through mild cognitive impairment (MCI) before the onset of AD is when it might be possible to introduce behavioral changes and pharma-nutritional interventions that modify the risk factors of MCI conversion to AD...
July 14, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30009933/extreme-enhancement-or-depletion-of-serotonin-transporter-function-and-serotonin-availability-in-autism-spectrum-disorder
#2
REVIEW
Valentina R Garbarino, T Lee Gilman, Lynette C Daws, Georgianna G Gould
A variety of human and animal studies support the hypothesis that serotonin (5-hydroxytryptamine or 5-HT) system dysfunction is a contributing factor to the development of autism in some patients. However, many questions remain about how developmental manipulation of various components that influence 5-HT signaling (5-HT synthesis, transport, metabolism) persistently impair social behaviors. This review will summarize key aspects of central 5-HT function important for normal brain development, and review evidence implicating perinatal disruptions in 5-HT signaling in the pathophysiology of autism spectrum disorder...
July 13, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29990625/targeting-mtors-by-omega-3-fatty-acids-a-possible-novel-therapeutic-strategy-for-neurodegeneration
#3
REVIEW
Samira Shirooie, Seyed Fazel Nabavi, Ahmad R Dehpour, Tarun Belwal, Solomon Habtemariam, Sandro Argüelles, Antoni Sureda, Maria Daglia, Michał Tomczyk, Eduardo Sobarzo-Sanchez, Suowen Xu, Seyed Mohammad Nabavi
Neurodegenerative diseases (NDs) such as Parkinson's (PD), Alzheimer's (AD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) cause significant world-wide morbidity and mortality. To date, there is no drug of cure for these, mostly age-related diseases, although approaches in delaying the pathology and/or giving patients some symptomatic relief have been adopted for the last few decades. Various studies in recent years have shown the beneficial effects of omega-3 poly unsaturated fatty acids (PUFAs) through diverse mechanisms including anti-inflammatory effects...
July 7, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29990624/the-anti-inflammatory-peptide-ac-sdkp-synthesis-role-in-ace-inhibition-and-its-therapeutic-potential-in-hypertension-and-cardiovascular-diseases
#4
REVIEW
Nitin Kumar, Congcong Yin
Cardiovascular diseases (CVDs) represent ∼31% of all global deaths, and hypertension alone accounts for ∼50% of these cases. Inflammation and subsequent fibrosis in heart, kidney and brain are associated with increased morbidity and mortality in CVD patients. N-Acetyl-Seryl-Aspartyl-Proline (Ac-SDKP) is a naturally occurring immunomodulatory and pro-angiogenic peptide mainly released from its precursor thymosin β4 (Tβ4) via enzymatic hydrolysis involving meprin-α and prolyl-oligopeptidase, while Ac-SDKP degradation is primarily carried out by angiotensin converting enzyme (ACE)...
July 7, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29990623/modifying-exosome-release-in-cancer-therapy-how-can-it-help
#5
REVIEW
Milad Moloudizargari, Mohammad Hossein Asghari, Mohammad Abdollahi
The reciprocal interactions of cancer cells with their microenvironment constitute an inevitable aspect of tumor development, progression and response to treatment in all cancers. Such bilateral transactions also serve as the key scenario underlying the development of drug resistance in many cases finally determining the fate of the disease and survival. In this view, a class of extracellular vesicles (EV) known as exosomes (EX) have been shown in the past few years to be important mediators of local and remote cell-to-cell contact changing the activity of their target cells by introducing their content of proteins, non-coding RNAs, and membrane-associated small molecules...
July 7, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30018026/resveratrol-stimulation-induces-interleukin-8-gene-transcription-via-nf-%C3%AE%C2%BAb
#6
Gerald Thiel, Myriam Ulrich, Naofumi Mukaida, Oliver G Rössler
The polyphenol resveratrol activates stimulus-regulated transcription factors, including activator protein-1 (AP-1). As part of a search for resveratrol-regulated target genes we analyzed the gene encoding the chemokine interleukin-8 (IL-8) which is regulated by AP-1. Here, we show that treatment of HEK293 cells with resveratrol induced the expression of IL-8 and activated transcription of a chromatin-embedded IL-8 promoter-controlled reporter gene. Mutational analysis of the IL-8 promoter revealed that it was not the AP-1 binding site, but rather the NF-κB site that was essential to connect resveratrol stimulation with the transcriptional activation of the IL-8 gene...
July 6, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29981776/protective-roles-of-melatonin-against-the-amyloid-dependent-development-of-alzheimer-s-disease-a-critical-review
#7
REVIEW
Bruno Vincent
Since its discovery almost 60 years ago by Lerner and colleagues, melatonin (N-acetyl-5-metoxytryptamine), a hormone mainly produced in the pineal gland, has been the subject of numerous investigations aimed at establishing its physiological functions. The subsequent seminal observation that melatonin levels decrease during normal aging, combined with the facts that AD patients show melatonin deficits when compared to age-matched controls and that the extent of melatonin loss in the cerebrospinal fluid parallels the progression of the disease, was the starting point of a series of studies, conducted during the past 20 years, aimed at determining whether this non-peptide hormone could reasonably be considered as a possible promising anti-AD compound and at establishing through which mechanisms it can control the time course of the disease...
July 5, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29969666/serotonin-1a-receptor-dependent-modulation-of-pain-and-reward-for-improving-therapy-of-chronic-pain
#8
REVIEW
Jabeen Haleem Darakhshan
Chronic pain conditions such as low back pain and osteoarthritis are the most prominent causes of disability worldwide. Morphine and other opioid drugs are the gold standard treatment for severe pain, including surgical pain, but the use of these drugs for chronic pain is limited largely because long term use of these drugs is associated with drug abuse and hyperalgesia which produces a negative impact on the treatment. Non-addictive treatments for chronic pain are, therefore, highly needed. Commonly used opioid drugs activate mu opioid receptors, resulting in an inhibition of tonic activity of nociceptive neurons...
June 30, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29964161/human-based-systems-mechanistic-nash-modelling-just-around-the-corner
#9
REVIEW
Joost Boeckmans, Alessandra Natale, Karolien Buyl, Vera Rogiers, Joery De Kock, Tamara Vanhaecke, Robim M Rodrigues
Non-alcoholic steatohepatitis (NASH) is a chronic liver disease characterized by excessive triglyceride accumulation in the liver accompanied by inflammation, cell stress and apoptosis. It is the tipping point to the life-threatening stages of non-alcoholic fatty liver disease (NAFLD). Despite the high prevalence of NASH, up to five percent of the global population, there are currently no approved drugs to treat this disease. Animal models, mostly based on specific diets and genetic modifications, are often employed in anti-NASH drug development...
June 29, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29964162/monographic-issue-of-pharmacological-research-on-hypertension
#10
EDITORIAL
Guido Grassi, Giuseppe Mancia
No abstract text is available yet for this article.
June 28, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29959993/label-free-cell-signaling-pathway-deconvolution-of-angiotensin-type-1-receptor-reveals-time-resolved-g-protein-activity-and-distinct-angii-and-angiii-iv-responses
#11
Sandrine Lavenus, Élie Simard, Élie Besserer-Offroy, Ulrike Froehlich, Richard Leduc, Michel Grandbois
Angiotensin II (AngII) type 1 receptor (AT1 R) is a G protein-coupled receptor known for its role in numerous physiological processes and its implication in many vascular diseases. Its functions are mediated through G protein dependent and independent signaling pathways. AT1 R has several endogenous peptidic agonists, all derived from angiotensinogen, as well as several synthetic ligands known to elicit biased signaling responses. Here, surface plasmon resonance (SPR) was used as a cell-based and label-free technique to quantify, in real time, the response of HEK293 cells stably expressing the human AT1 R...
June 27, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29959032/which-is-the-best-combination-of-tace-and-sorafenib-for-advanced-hepatocellular-carcinoma-treatment-a-systematic-review-and-network-meta-analysis
#12
REVIEW
Fan Feng, Qiyu Jiang, Hui Jia, Huiwei Sun, Yantao Chai, Xiaojuan Li, Guanghua Rong, Yingshi Zhang, Zhengping Li
The aim of this study was to assess the comparative efficacy and safety of combination therapy with transarterial chemoembolization (TACE) and Sorafenib for patients with advanced hepatocellular carcinoma (HCC) through a systematic review and network meta-analysis and identify the best combination of TACE and Sorafenib. We searched databases for publications prior to May 2018. The prespecified efficacy outcomes were the objective response rate, overall survival rate, and time to progression. adverse effects included dermatologic, gastrointestinal, and general disorders...
June 26, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29959031/changes-in-left-ventricular-geometry-during-antihypertensive-treatment
#13
REVIEW
Massimo Salvetti, Anna Paini, Fabio Bertacchini, Deborah Stassaldi, Carlo Aggiusti, Claudia Agabiti Rosei, Davide Bassetti, Enrico Agabiti-Rosei, Maria Lorenza Muiesan
The reduction of echocardiographic left ventricular (LV) mass and the change toward a less concentric geometry during antihypertensive treatment are independently associated with a better prognosis. Blood pressure-lowering treatment may reduce cardiac hypertrophy, although different effect on changes of LV mass have been reported among antihypertensive drug classes, while changes in echocardiographic evaluated LV geometry have not been systemically evaluated. It is not yet clear whether antihypertensive drugs may influence LV geometry...
June 26, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29958147/drugs-for-treatment-for-alcohol-use-disorders-expose-to-interactions-with-others-%C3%A2-for-little-benefit-if-any
#14
LETTER
Alain Braillon
No abstract text is available yet for this article.
June 26, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29953944/response-to-drugs-for-treatment-for-alcohol-use-disorders-expose-to-interactions-with-others-%C3%A2-for-little-benefit-if-any
#15
LETTER
Simona Guerzoni, Lanfranco Pellesi, Luigi Alberto Pini, Fabio Caputo
No abstract text is available yet for this article.
June 25, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29953943/beyond-a-neurotransmitter-the-role-of-serotonin-in-inflammation-and-immunity
#16
REVIEW
Hera Wu, Travis H Denna, Jordan N Storkersen, Valerie A Gerriets
Serotonin (5-HT), a well-known neurotransmitter in the brain, also plays an important role in peripheral tissues, including the immune system. There is a growing body of evidence suggesting that many different types of immune cells express the machinery to generate, store, respond to and/or transport serotonin, including T cells, macrophages, mast cells, dendritic cells and platelets. In addition, there is emerging evidence of a possible connection between T cells, serotonin and mood disorders. How 5-HT interacts with the peripheral immune system and if this signaling is associated with behavioral phenotypes found in mood disorders like major depressive disorder (MDD) is not well understood...
June 25, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29944980/changes-in-cell-morphology-guide-identification-of-tubulin-as-the-off-target-for-protein-kinase-inhibitors
#17
Monira Hoque, Ramzi H Abbassi, Danielle Froio, Jennifer Man, Terrance G Johns, Brett W Stringer, Bryan W Day, Marina Pajic, Michael Kassiou, Lenka Munoz
In the field of kinase inhibitors for applications in cancer research, tubulin is emerging as a targeted cellular protein that can significantly contribute to their activities. However, investigation of kinase inhibitors beyond the kinome is an area often neglected. Herein, we describe the results of pharmacological studies using drugs targeting kinases, tubulin or both. A key finding is that if cells are treated with a kinase inhibitor unintentionally targeting tubulin, their characteristic shape will diminish within a short timeframe...
June 23, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29935947/add-on-therapy-with-traditional-chinese-medicine-an-efficacious-approach-for-lipid-metabolism-disorders
#18
REVIEW
Ying Zhang, Hiroko Kishi, Sei Kobayashi
Add-on therapy with traditional Chinese medicine (TCM) has been extensively researched in the intractable diseases, such as asthma, cancer, and Alzheimer's disease. As an entirely new concept, add-on therapy of TCM has been also used to prevent and treat hyperlipidemia via lowering cholesterol level. However, the efficacy of add-on therapy with TCM for mediating lipid metabolism disorders remains controversial. In this review, we summarize and provide strong evidence that add-on therapy of TCM as a novel approach is efficacious and safe for hyperlipidemia associated diseases based on the mediation of lipid metabolism disorders...
June 21, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29935946/what-is-the-role-of-endogenous-gut-serotonin-in-the-control-of-gastrointestinal-motility
#19
REVIEW
Damien J Keating, Nick J Spencer
In recent years, there have been dramatic changes in our understanding of the role of endogenous 5-Hydroxytryptamine (5-HT or serotonin) in the control of gastrointestinal (GI) motility. Whilst it is well accepted that there are numerous types of 5-HT receptors expressed on enteric neurons and that exogenous 5-HT potently stimulates GI-motility, understanding the role of endogenous 5-HT in GI-motility has been substantially more difficult to resolve. Recent studies found 5-HT3 and 5-HT4 antagonists have the same effects on peristalsis in colon preparations depleted of endogenous 5-HT...
June 21, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29935272/microrna-profiles-in-serum-samples-from-patients-with-stable-cirrhosis-and-mirna-21-as-a-predictor-of-transplant-free-survival
#20
Alex Evangelista do Amaral, Michele Patrícia Rode, Julia Cisilotto, Telma Erotides da Silva, Josiane Fischer, Camila Matiollo, Elayne Cristina de Morais Rateke, Janaína Luz Narciso-Schiavon, Leonardo Lucca Schiavon, Tânia Beatriz Creczynski-Pasa
MicroRNAs (miRNAs) have remarkable potential as diagnostic and prognostic markers because of their roles in disease pathogenesis. miRNAs can be released into the bloodstream, where they are sufficiently stable to be detected noninvasively. Here, we prospectively evaluated serum levels of miR-21, miR-34a, miR-122, miR-181b, and miR-885-5p in patients with stable cirrhosis. Total RNA was extracted from the sera of patients with cirrhosis and healthy individuals, and the expression levels of the target miRNAs were analyzed by reverse transcription-quantitative polymerase chain reaction...
June 20, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
journal
journal
30115
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"