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Pharmacological Research: the Official Journal of the Italian Pharmacological Society

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https://www.readbyqxmd.com/read/30414893/negative-regulation-of-angiogenesis-by-novel-micro-rnas
#1
Veronica Sanchez, Flora Golyardi, Dominique Mayaki, Raquel Echavarria, Sharon Harel, Janguo Xia, Sabah N A Hussain
Angiopoietin-1 (Ang-1) is a ligand of Tie-2 receptors that promotes survival, migration, and differentiation of endothelial cells (ECs). Recent studies have identified several microRNA (miRNA) families that either promote or inhibit angiogenesis. To date, the nature and functional importance of miRNAs in Ang-1-induced angiogenesis are unknown. Microarray screening of known miRNAs in human umbilical vein endothelial cells (HUVECs) revealed that the expressions of miR-103b, miR-330-5p, miR-557, miR-575, miR-1287-5p, and miR-1468-5p significantly decrease following exposure to Ang-1 for 24 hr...
November 8, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30414892/decrease-in-14-3-3%C3%AE-protein-levels-is-correlated-with-improvement-in-disease-activity-in-patients-with-rheumatoid-arthritis-treated-with-tofacitinib
#2
O Shovman, B Gilburd, A Watad, H Amital, P Langevitz, N L Bragazzi, M Adawi, D Perez, M Lidar, I Katz, M Blank, N K Biln, A Marotta, Y Shoenfeld
14-3-3η protein is a proinflammatory mediator that may represent a novel diagnostic and prognostic biomarker for rheumatoid arthritis (RA). We assessed the correlation between changes in serum 14-3-3η levels and changes in clinical disease activity measures in RA patients treated with Tofacitinib (TOF). Paired serum samples from 35 patients with RA were obtained at baseline and 5 months after the initiation of treatment with TOF. The levels of 14-3-3η were measured by JOINT stat 14-3-3η ELISA test kits (Augurex Life Sciences Corp...
November 8, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30412733/plant-derived-medicines-for-treatment-of-endometriosis-a-comprehensive-review-of-molecular-mechanisms
#3
REVIEW
Fatemeh Bina, Samaneh Soleymani, Tayebeh Toliat, Mannan Hajimahmoodi, Malihe Tabarrai, Mohammad Abdollahi, Roja Rahimi
Endometriosis is an estrogen-dependent disease with inflammatory lesions at extra-uterine sites, causing pelvic pain and fertility reduction. Conventional therapies primarily focus on reducing systemic levels of estrogens; however, they do not have desirable effectiveness and possess considerable side effects. Therefore, there is a growing interest in the use of herbal medicine for the treatment of endometriosis. In this paper, electronic databases including PubMed, Scopus, Cochrane library and Google Scholar were searched to obtain any studies evaluating any herbal products in the management of endometriosis...
November 6, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30408575/curcumin-in-combination-with-anti-cancer-drugs-a-nanomedicine-review
#4
REVIEW
Harshul Batra, Shrikant Pawar, Dherya Bahl
A huge surge of research is being conducted on combination therapy with anticancer compounds formulated in the form of nanoparticles (NPs). Numerous advantages like dose minimalization and synergism, reversal of multi drug resistance (MDRs), enhanced efficacy have emerged with nanoencapsulation of chemotherapeutic agents with chemo-sensitizing agent like curcumin. Within last couple of years various nano-sized formulations have been designed and tested both in vitro with cell lines for different types of cancers and in vivo with cancer types and drug resistance models...
November 5, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30408574/identification-of-factors-associated-with-first-cycle-drug-approval-rates-and-regulatory-outcomes-for-new-drug-applications
#5
Lin-Chau Chang, Margaret Vanheusen, Xiao Fang, Christopher D Breder
The aims of this study were to identify types of deficiencies resulting in delay of approvals for drugs eventually approved by the US FDA and to search for factors associated with higher first-cycle approval rates. Review documents of New Drug Applications approved between 2008 and 2017 were retrieved from the Drugs@FDA database. Basic characteristics of the applications, regulatory actions, and reasons for non-approvals and/or major amendments after first review cycle were investigated. Of 825 applications studied, 446 (54...
November 5, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30408573/the-effect-of-polypharmacy-on-prefrontal-cortex-activation-during-single-and-dual-task-walking-in-community-dwelling-older-adults
#6
Claudene J George, Joe Verghese, Meltem Izzetoglu, Cuiling Wang, Roee Holtzer
INTRODUCTION: Polypharmacy, defined as the use of 5 or more medications is associated with multiple adverse outcomes in older adults, including falls and slow gait velocity. However, the relationship between polypharmacy and cortical control of locomotion has not been reported. The purpose of this study was to examine the relationship between polypharmacy and activation patterns in the prefrontal cortex (PFC), a brain region involved in higher order control of locomotion during attention-demanding conditions...
November 5, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30408572/long-term-effectiveness-of-bisoprolol-in-patients-with-angina-a-real-world-evidence-study
#7
Sabidó Meritxell, Hohenberger Thilo, Grassi Guido
A cohort analysis using UK Clinical Practice Research Datalink (CPRD) was performed to compare the effects of bisoprolol, other β-blockers, and drugs other than β-blockers on the long-term risk of mortality and cardiovascular events in patients with angina. Adult patients first diagnosed with angina from 2000 to 2014, with ≥365 days of registration to first angina diagnosis and initiating monotherapies of bisoprolol, other β-blockers, or drugs other than β-blockers within 6 months of angina diagnosis were included...
November 5, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30408571/danhong-injection-in-cardiovascular-and-cerebrovascular-diseases-cardiovascular-actions-molecular-mechanisms-and-therapeutic-potential
#8
REVIEW
Xiaojun Feng, Yi Li, Yanan Wang, Lingli Li, Peter J Little, Suo-Wen Xu, Sheng Liu
Cardiovascular and cerebrovascular diseases are the main cause of mortality worldwide, currently with less than optimum therapeutic options. Danhong injection (DHI) is a medicinal preparation based on two eminent Chinese herbal medicines, Salviae Miltiorrhizae (Dan Shen; family: Lamiaceae) and Flos Carthami (Hong Hua; family: Compositae/Asteraceae). DHI has been mainly used in the clinical therapy of cardiovascular (such as acute coronary syndrome and angina pectoris) and cerebrovascular diseases (such as stroke) in China for many years...
November 5, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30395946/salvia-miltiorrhiza-protects-against-diabetic-nephropathy-through-metabolome-regulation-and-wnt-%C3%AE-catenin-and-tgf-%C3%AE-signaling-inhibition
#9
Xiang Xiang, Hong-Die Cai, Shu-Lan Su, Xin-Xin Dai, Yue Zhu, Jian-Ming Guo, Hui Yan, Sheng Guo, Wei Gu, Da-Wei Qian, Zhi-Shu Tang, Jin-Ao Duan
Diabetic nephropathy (DN) is a complication of diabetes that is caused by uncontrolled high blood sugar. It has been reported that Salvia miltiorrhiza (SM) possesses the ability to prevent kidney damage, although the mechanisms remain unclear. The study was to investigate whether and how SM improved DN injury via regulation of metabolome and the molecular mechanisms. In this study, SD rats were fed a high glucose / high fat diet accompanied by 0.5% glucose water. Three weeks later, the rats were given one intraperitoneal injection of 30 mg/kg STZ each day for three days for DN model...
November 3, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30395950/etrolizumab-versus-infliximab-in-the-treatment-of-induction-phase-of-ulcerative-colitis-a-systematic-review-and-indirect-comparison
#10
REVIEW
Ehsan Motaghi, Masoumeh Ghasemi-Pirbaluti, Mohsen Zabihi
OBJECTIVES: There is still a need to develop new effective medications for the treatment of ulcerative colitis, particularly for patients who are intolerant or resistant to first line therapies. This article compared the efficacy and safety of etrolizumab and infliximab in moderate to severe ulcerative colitis. METHODS: This meta-analysis was performed according to the PRISMA statement protocol. A systematic literature search of three major bibliographic databases (Scopus, PubMed, and Cochran) was performed until June 30, 2018...
November 2, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30395949/3d-organ-models-revolution-in-pharmacological-research
#11
REVIEW
Marie Weinhart, Andreas Hocke, Stefan Hippenstiel, Jens Kurreck, Sarah Hedtrich
3D organ models have gained increasing attention as novel preclinical test systems and alternatives to animal testing. Over the years, many excellent in vitro tissue models have been developed. In parallel, microfluidic organ-on-a-chip tissue cultures have gained increasing interest for their ability to house several organ models on a single device and interlink these within a human-like environment. In contrast to these advancements, the development of human disease models is still in its infancy. Although major advances have recently been made, efforts still need to be intensified...
November 2, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30395948/cognition-and-behavior-in-sheep-repetitively-inoculated-with-aluminum-adjuvant-containing-vaccines-or-aluminum-adjuvant-only
#12
Javier Asín, María Pascual-Alonso, Pedro Pinczowski, Marina Gimeno, Marta Pérez, Ana Muniesa, Lorena de Pablo, Ignacio de Blas, Delia Lacasta, Antonio Fernández, Damián de Andrés, Gustavo María, Ramsés Reina, Lluís Luján
Aluminum (Al)-containing vaccines are common in sheep management and they have been associated with the Autoimmune/inflammatory Syndrome Induced by Adjuvants (ASIA syndrome). The aim of this study was to investigate cognitive and behavioral changes in sheep subjected to a protocol of repetitive inoculation with Al-containing products. Twenty-one lambs were assigned to three groups (n = 7 each): A (Control), B (Adjuvant-only), C (Vaccine). Group C was inoculated with commercial Al-containing vaccines; Group B received the equivalent dose of Al only (Alhydrogel® ) and Group A received PBS...
November 2, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30395947/molecular-pharmacology-of-inflammation-medicinal-plants-as-anti-inflammatory-agents
#13
REVIEW
Shumaila Tasneem, Bin Liu, Bin Li, M Iqbal Choudhary, Wei Wang
Except for an essential step for the pathology of multiple diseases including atherosclerosis and rheumatoid arthritis, inflammation is an imperative therapeutic target for developing novel approaches for pharmacological interventions. Thus, molecular understanding of inflammation not only revealed the mechanisms of drug action and their biological targets but also has spawned innovative maneuvers to influence multifaceted biological systems, providing new prospects for drug designing and suggesting important new implications for existing clinical medicine...
November 2, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30391353/the-antidiabetic-drug-metformin-prevents-and-reverses-neuropathic-pain-and-spinal-cord-microglial-activation-in-male-but-not-female-mice
#14
Kufreobong E Inyang, Thomas Szabo-Pardi, Emma Wentworth, Timothy A McDougal, Gregory Dussor, Michael D Burton, Theodore J Price
Metformin is a widely prescribed drug used in the treatment of type II diabetes. While the drug has many mechanisms of action, most of these converge on AMP activated protein kinase (AMPK), which metformin activates. AMPK is a multifunctional kinase that is a negative regulator of mechanistic target of rapamycin (mTOR) and mitogen activated protein kinase (MAPK) signaling. Activation of AMPK decreases the excitability of dorsal root ganglion neurons and AMPK activators are effective in reducing chronic pain in inflammatory, post-surgical and neuropathic rodent models...
November 1, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30391352/painless-nerve-growth-factor-a-trka-biased-agonist-mediating-a-broad-neuroprotection-via-its-actions-on-microglia-cells
#15
REVIEW
Antonino Cattaneo, Simona Capsoni
Nerve Growth Factor (NGF) is a therapeutic candidate for Alzheimer's disease, based on its well known actions on basal forebrain cholinergic neurons. However, because of its pro-nociceptive activity, in current clinical trials NGF has to be administered intraparenchymally into the brain by neurosurgery via cell or gene therapy approaches. To prevent the NGF pain-inducing collateral effects, thus avoiding the necessity for local brain injection, we developed painless NGF (hNGFp), based on the human genetic disease Hereditary Sensory and Autonomic Neuropathy type V (HSAN V)...
November 1, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30391354/pharmacological-inhibition-of-bacterial-%C3%AE-glucuronidase-prevents-irinotecan-induced-diarrhea-without-impairing-its-antitumor-efficacy-in-vivo
#16
Kai-Wen Cheng, Chih-Hua Tseng, Cherng-Chyi Tzeng, Yu-Lin Leu, Ta-Chun Cheng, Jaw-Yuan Wang, Jia-Ming Chang, Yun-Chi Lu, Chiu-Min Cheng, I-Ju Chen, Yi-An Cheng, Yeh-Long Chen, Tian-Lu Cheng
Irinotecan (CPT-11), a first-line chemotherapy for advanced colorectal cancer, causes serious diarrhea in patients receiving treatment. The underlying mechanism has been shown that the active metabolite of CPT-11, SN-38, is metabolized to the inactive metabolite SN-38 glucuronide (SN-38 G) during hepatic glucuronidation, and subsequently is exported into the intestine, where SN-38 G is hydrolyzed by bacterial β-glucuronidase (βG) to be SN-38, thus leading to intestinal toxicity. Thus, inhibition of the intestinal bacterial βG activity is expected to prevent CPT-11-induced diarrhea...
October 31, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30385365/epigenetic-targeting-dnmt1-of-pancreatic-ductal-adenocarcinoma-using-interstitial-control-release-biodegrading-polymer-reduced-tumor-growth-through-hedgehog-pathway-inhibition
#17
Mao-Hsuan Huang, Yi-Wen Chou, Ming-Hsun Li, Tina E Shih, Shinn-Zong Lin, Hong-Meng Chuang, Tzyy-Wen Chiou, Hong-Lin Su, Horng-Jyh Harn
Annually, 48,000 people die from pancreatic ductal adenocarcinoma (PDAC), ranking it the fourth among cancer-related deaths in the United States. Currently, anti-cancer drugs are not effective against PDAC, and only extends survival by 3 months. Aberrant DNA methylation has been shown to play an important role during carcinogenesis in PDAC, with approximately 80% of tumor overexpressing the DNA methyltransferase 1 (DNMT1) protein. In the present study, we used DNMTs as a screening platform to find a new DNMT inhibitor, n-butylidenephthalide (n-BP), which is identified from a Chinese herbal drug...
October 29, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30385364/the-emergence-of-loss-of-efficacy-during-antidepressant-drug-treatment-for-major-depressive-disorder-an-integrative-review-of-evidence-mechanisms-and-clinical-implications
#18
REVIEW
Michele Fornaro, Annalisa Anastasia, Stefano Novello, Andrea Fusco, Riccardo Pariano, Domenico De Berardis, Marco Solmi, Nicola Veronese, Brendon Stubbs, Eduard Vieta, Michael Berk, Andrea de Bartolomeis, André F Carvalho
The re-emergence (i.e. 'breakthrough') of depressive symptoms despite maintenance treatment of depression with antidepressant drugs is a complex clinical phenomenon referred to as tolerance. Herein we critically appraise evidence from both pre-clinical and clinical studies, focusing on putative mechanisms as well as clinical correlates and implications of the emergence tolerance during antidepressant treatment for major depressive disorder (MDD). It is firstly unclear to what extent this phenotype reflects a pharmacological effect of an antidepressant, is driven by non-adherence, is a marker of latent bipolarity or another comorbidity, a marker of neuroprogression of the underlying disorder or the intrusion of the impact of psychosocial variables into the clinical course...
October 29, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30394320/gene-silencing-of-receptor-interacting-protein-2-protects-against-cigarette-smoke-induced-acute-lung-injury
#19
Jinrui Dong, Wupeng Liao, Lay Hong Tan, Amy Yong, Wen Yan Peh, W S Fred Wong
BACKGROUND AND PURPOSE: Chronic obstructive pulmonary disease (COPD) is characterized by progressive alveolar damage and generally irreversible airflow limitation. Nuclear factor-κB (NF-κB) plays a critical role in COPD pathogenesis. Receptor-interacting protein 2 (Rip2), a 60 kDa adaptor protein, is a positive regulator of NF-κB pathway and also an inducible transcriptional product of NF-κB activation. We sought to investigate if Rip2 gene silencing could protect against cigarette smoke (CS)-induced acute lung injury...
October 27, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30394319/post-translational-modifications-of-serotonin-transporter
#20
REVIEW
Anthonya Cooper, Donna Woulfe, Fusun Kilic
The serotonin transporter (SERT) is an oligomeric glycoprotein with two sialic acid residues on each of two complex oligosaccharide molecules. Studies using in vivo and in vitro model systems demonstrated that diverse post-translational modifications, including phosphorylation, glycosylation, serotonylation, and disulfide bond formation, all favorably influences SERT conformation and allows the transporter to function most efficiently. This review discusses the post-translational modifications and their importance on the structure, maturation, and serotonin (5-HT) uptake ability of SERT...
October 27, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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