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Perspectives on topology of the human m 1 A methylome at single nucleotide resolution.
RNA 2018 November
N 1 -methyladenosine was recently reported to be a chemical modification in mRNA. However, while we identified hundreds of m1 A sites in the human transcriptome in a previous work, others have detected only nine sites in cytosolic and mitochondrial mRNAs. Herein, we provide additional evidence that hundreds of m1 A sites are present in the human transcriptome. Moreover, we show that both the improper bioinformatic tools and the poor quality of sequencing data in a previous study led to the failure in identifying the majority of m1 A sites. Our analysis hence provides an explanation of the divergence in the prevalence of this newly discovered mRNA mark.
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