The headache of the post transurethral prostate surgery pyuria: Pursuit for evidence.

• Objective To prospectively assess early post-TUPS (transurethral prostate surgery) urinalysis changes and bacteriuria with its clinical relevance. • Methods Patients with BPO enrolled for TUPS were prospectively assessed. Patients were assessed at 2, 4, 8, 12, and 24-weeks postoperatively by DVAS (dysuria-visual-analogue-scale), IPSS-QOL, uroflow, and PVR. Routine urinalysis was performed before discharge and at all visits. MSUC (midstream urine culture) was performed before discharge, 4 and 12-weeks postoperatively. • Results At final analysis 152 patients were evaluable. Significant pyuria was reported in 52%, 96.1%, 94.1%, 71.7%, 78.9% and 52.5% in before discharge, 2-, 4-, 8-, 12-, and 24-weeks urinalysis postoperative respectively. The mean time to non-significant-pyuria (95%CI) was 19.1(17.5-20.7), 20.1(17.3-22.9), 15.8(12.8-18.8) and 14(10.3-17.8) weeks after prostate resection, vaporization, enucleation, and incision respectively, (P0.03). Regardless of the TUPS technique, half of the patients had significant pyuria at 24-weeks postoperative. MSUC was positive in 37/152(24.3%), 3/152(2%), 23/152(15.1%), and 5/152(3.3%) preoperatively, before discharge, 4 and 12-weeks postoperative respectively. Only positive preoperative urine leucocyte esterase independently predicted positive 4-weeks MSUC (OR3.8, 95%CI1.3-11.1, P0.013). No significant correlation was found between IPSS or DVAS and positive MSUC nor between IPSS and postoperative pyuria at different follow-up points (P>0.05). However, the degree of postoperative dysuria was significantly correlated with postoperative pyuria count by urinalysis at 2-Weeks (r0.69, P0.03), 8-Weeks (r0.26, P0.001) and 12-Weeks (r0.23, P0.004). • Conclusion There is a persistent but gradually declining pyuria and microhematuria following TUPS up to 6 months postoperative. An earlier resolution was noted following prostate incision and enucleation. While routine urine analyses screening in these months would be of no clear clinical value, a routine urine culture would be of a reasonable significance at 1 month post-operatively.