Correlation and Influencing Factors of Neurophysiological Examinations and Serum Uric Acid in Patients with Diabetic Peripheral Neuropathy: An Exploratory Study.

Objective: This study aimed to investigate the correlation and influencing factors between neurophysiological examinations, serum uric acid (SUA), and glucose metabolism in patients with Diabetic Peripheral Neuropathy (DPN). Methods: A total of 114 patients with DPN who received treatment at the Endocrinology Department of our hospital from January 2022 to December 2023 were included. According to the median blood uric acid level, the patients were divided into high SUA group and low SUA group, and the demographic data, blood glucose indexes and sensory nerve electrophysiological examination results of the two groups were compared. Results: The level of FPG and HbA1c was higher in the high SUA group. The sensory nerve latency of the high SUA group was higher, the sensory nerve amplitude and sensory nerve conduction velocity of the high SUA group were lower than those of the low SUA group. The sensory nerve latency of the high SUA group was higher, the sensory nerve amplitude and sensory nerve conduction velocity of the high SUA group were lower than those of the low SUA group. SUA was positively correlated with sensory nerve latency and negatively correlated with sensory nerve amplitude and conduction velocity. Conclusion: In DPN, high SUA levels are associated with poor glycemic control. With the increase in SUA levels, the sensory nerve latency in patients with T2DM is prolonged, and amplitude and conduction velocity decrease, and high SUA is a risk factor and potential predictor of DPN.