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International Journal of Obesity: Journal of the International Association for the Study of Obesity

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https://www.readbyqxmd.com/read/29257801/author-s-response-to-letter-to-the-editor-regression-to-the-mean-apparent-data-errors-and-biologically-extraordinary-results
#1
R Dershem, X Chu, G C Wood, P Benotti, C D Still, D D Rolston
International Journal of Obesity accepted article preview online, 19 December 2017. doi:10.1038/ijo.2017.300.
December 19, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29235554/morning-and-afternoon-appetite-and-gut-hormone-responses-to-meal-and-stress-challenges-in-obese-individuals-with-and-without-binge-eating-disorder
#2
S Carnell, C Grillot, T Ungredda, S Ellis, N Mehta, J Holst, A Geliebter
BACKGROUND: Eating late in the day is common, and stress can induce eating. Little is understood about how time of day and stress interact to affect appetite and thereby body weight. These may be particularly important influences in binge eaters, who tend to binge in the evening, and in response to stress. METHOD: Obese participants with (n=16) and without (n=16) Binge Eating Disorder (BED) participated in two identical test protocols beginning either in the morning or the afternoon (AM condition/PM condition), each following an 8 h fast...
December 13, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29235553/pro-inflammatory-gene-expression-profile-in-obese-adults-with-high-plasma-gip-levels
#3
J Góralska, U Raźny, A Polus, J Stancel-Możwiłło, M Chojnacka, A Gruca, A Zdzienicka, A Dembińska-Kieć, B Kieć-Wilk, B Solnica, M Malczewska-Malec
BACKGROUND: GIP provides a novel link between the immune system and the gut, although results from different experimental and observational studies are contradictory, ranging from anti-inflammatory, through neutral to pro-inflammatory action of GIP. Thus, the aim of this study was to analyze inflammatory pathways on the level of gene expression and circulating inflammatory markers in relation to plasma GIP level. SUBJECTS/METHODS: The study included 128 obese adults...
December 13, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29229970/regression-to-the-mean-apparent-data-errors-and-biologically-extraordinary-results-letter-regarding-changes-in-telomere-length-3-5-years-after-gastric-bypass-surgery
#4
D L Smith, D M Thomas, C O Siu, S Verhulst, D B Allison
International Journal of Obesity accepted article preview online, 12 December 2017. doi:10.1038/ijo.2017.298.
December 12, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29211707/obesity-and-obesogenic-growth-are-both-highly-heritable-and-modified-by-diet-in-a-nonhuman-primate-model-the-african-green-monkey-chlorocebus-aethiops-sabaeus
#5
C A Schmitt, S K Service, A J Jasinska, T D Dyer, M J Jorgensen, R M Cantor, G M Weinstock, J Blangero, J R Kaplan, N B Freimer
OBJECTIVE: In humans, the ontogeny of obesity throughout the life course and the genetics underlying it has been historically difficult to study. We compared, in a non-human primate model, the lifelong growth trajectories of obese and non-obese adults, to assess the heritability of and map potential genomic regions implicated in growth and obesity. STUDY POPULATION: A total of 905 African green monkeys, or vervets (Chlorocebus aethiops sabaeus) (472 females, 433 males) from a pedigreed captive colony...
December 6, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29211706/response-to-jangle-fallacy-epidemic-in-obesity-research-a-comment-on-ruddock-et-al-2017
#6
H K Ruddock, P Christiansen, J C G Halford, C A Hardman
International Journal of Obesity accepted article preview online, 06 December 2017. doi:10.1038/ijo.2017.290.
December 6, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29211705/a-workshop-on-dietary-sweetness-is-it-an-issue
#7
A Wittekind, K Higgins, L McGale, C Schwartz, N S Stamataki, G K Beauchamp, A Bonnema, P Dussort, S Gibson, C de Graaf, J C G Halford, C F M Marsaux, R D Mattes, J McLaughlin, D J Mela, S Nicklaus, P J Rogers, I A Macdonald
This report summarises a workshop convened by ILSI Europe on 3rd and 4th April 2017 to discuss the issue of dietary sweetness. The objectives were to understand the roles of sweetness in the diet; establish whether exposure to sweetness affects diet quality and energy intake; and consider whether sweetness per se affects health. Although there may be evidence for tracking of intake of some sweet components of the diet through childhood, evidence for tracking of whole diet sweetness, or through other stages of maturity are lacking...
December 6, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29203860/adipose-tissue-mitochondrial-capacity-associates-with-long-term-weight-loss-success
#8
R Jokinen, R Rinnankoski-Tuikka, S Kaye, L Saarinen, S Heinonen, M Myöhänen, E Rappou, S Jukarainen, A Rissanen, A Pessia, V Velagapudi, K A Virtanen, E Pirinen, K H Pietiläinen
OBJECTIVES: We investigated whether (1) subcutaneous adipose tissue (SAT) mitochondrial capacity predicts weight loss success and (2) weight loss ameliorates obesity-related SAT mitochondrial abnormalities. METHODS: SAT biopsies were obtained from 19 clinically healthy obese subjects (BMI 34.6±2.7 kg/m2) during a weight-loss intervention (0, 5, and 12 months) and from 19 lean reference subjects (BMI 22.7±1.1 kg/m2) at baseline. Based on one-year weight loss outcome, the subjects were divided into two groups: continuous weight losers (WL, n=6) and weight regainers (WR, n=13)...
December 5, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29188821/response-to-how-much-does-the-addiction-like-eating-behaviour-scale-add-to-the-debate-regarding-food-versus-eating-addictions
#9
H K Ruddock, P Christiansen, J C G Halford, C A Hardman
International Journal of Obesity accepted article preview online, 30 November 2017. doi:10.1038/ijo.2017.291.
November 30, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29188820/identification-of-novel-alleles-associated-with-insulin-resistance-in-childhood-obesity-using-pooled-dna-genome-wide-association-study-approach
#10
P Kotnik, E Knapič, J Kokošar, J Kovač, R Jerala, T Battelino, S Horvat
BACKGROUND: Recently, we witnessed great progress in the discovery of genetic variants associated with obesity and T2D, especially in adults. Much less is known regarding genetic variants associated with insulin resistance (IR). We hypothesized that novel IR genes could be efficiently detected in a population of obese children and adolescents who may not exhibit comorbidities and other confounding factors. OBJECTIVES: This study aimed to determine if a genome wide association study (GWAS), using a DNA pooling approach, could identify novel genes associated with IR...
November 30, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29188819/colonic-bacteroides-are-positively-associated-with-trabecular-bone-structure-and-programmed-by-maternal-vitamin-d-in-male-but-not-female-offspring-in-an-obesogenic-environment
#11
C R Villa, A Taibi, J Chen, W E Ward, E M Comelli
BACKGROUND/OBJECTIVES: The gut microbiota is determined early in life, possibly including pregnancy. Pioneering data suggests vitamin D, a nutrient important for bone health, affects this microbiota. We found that high maternal vitamin D lowered circulating lipopolysaccharide, improved intestinal barrier and bone health in male but not female offspring in an obesogenic environment. This study determined if high maternal dietary vitamin D programs Bacteroides and Prevotella and whether this associates with bone mineral content, density and structure of male and female adult offspring fed an obesogenic diet...
November 30, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29188818/no-evidence-of-white-adipocyte-browning-after-endurance-exercise-training-in-obese-men
#12
T Tsiloulis, A L Carey, J Bayliss, B Canny, R C R Meex, M J Watt
BACKGROUND/OBJECTIVES: The phenomenon of adipocyte 'beiging' involves the conversion of non-classic brown adipocytes to brown-like adipose tissue with thermogenic, fat-burning properties, and this phenomenon has been shown in rodents to slow the progression of obesity-associated metabolic diseases. Rodent studies consistently report adipocyte beiging after endurance exercise training, indicating that increased thermogenic capacity in these adipocytes may underpin the improved health benefits of exercise training...
November 30, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29188817/dietary-sugar-intake-was-associated-with-increased-body-fatness-but-decreased-cardiovascular-mortality-in-chinese-elderly-an-11-year-prospective-study-of-mr-and-ms-os-hong-kong
#13
Z-M Liu, S L A Tse, D Chan, C Wong, Sy-S Wong
BACKGROUND/OBJECTIVES: Epidemiological studies suggest that sugar intake contributes to weight gain and increased risk of cardiovascular diseases (CVD). However, this association is largely undefined in the elderly population. Our aim was to investigate the effect of sugar consumption on the subsequent changes in body fatness and CVD mortality in Chinese elderly. METHODS: A total of 2000 men and 2000 women aged ⩾65 years were recruited from 2001 to 2003. Dietary sugar intake was estimated based on a validated 329-item food frequency questionnaire and a local sugar database...
November 30, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29180723/neuromodulation-of-orexin-neurons-reduces-diet-induced-adiposity
#14
A N Zink, P E Bunney, A A Holm, C J Billington, C M Kotz
BACKGROUND/OBJECTIVES: Low levels of orexin are associated with obesity and reduced physical activity in humans and animals. SUBJECTS/METHODS: Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) selectively activated orexin neurons in mouse lateral hypothalamus (LH) to measure effects on spontaneous physical activity (SPA). DREADD targeting was achieved by stereotaxic injection of AAV vectors into caudal lateral LH of heterozygous orexin Cre or C57/B6J mice...
November 28, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29167556/alterations-in-gut-microbiota-associated-with-a-cafeteria-diet-and-the-physiological-consequences-in-the-host
#15
J M Del Bas, M Guirro, N Boqué, A Cereto, R Ras, A Crescenti, A Caimari, N Canela, L Arola
OBJECTIVE: Gut microbiota have been described as key players in the pathophysiology of obesity and different components of metabolic syndrome (MetS). The cafeteria diet (CAF)-fed rat is a preclinical model that reproduces most of the alterations found in human MetS by simulating a palatable human unbalanced diet. Our objective was to assess the effects of CAF on gut microbiota and their associations with different components of MetS in Wistar rats. METHODS: Animals were fed a standard diet or CAF for 12 weeks...
November 23, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29158543/genetic-predisposition-to-obesity-restrained-eating-and-changes-in-body-weight-a-population-based-prospective-study
#16
H Konttinen, C Llewellyn, K Silventoinen, A Joensuu, S Männistö, V Salomaa, P Jousilahti, J Kaprio, M Perola, A Haukkala
OBJECTIVES: There is no consensus on whether cognitive control over food intake (i.e. restrained eating) is helpful, merely ineffective or actually harmful in weight management. We examined the interplay between genetic risk of obesity, restrained eating and changes in body weight and size. METHODS: Participants were Finnish 25- to 74-year-olds who attended the DILGOM study at baseline in 2007 and follow-up in 2014. At baseline (n=5024), height, weight and waist circumference (WC) were measured in a health examination and participants self-reported their weight at age 20 years...
November 21, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29158542/metabolic-profiling-of-umbilical-cord-blood-in-macrosomia
#17
H Sun, Y Wang, C Wang, X Xu, Y Wang, H Yan, X Yang
BACKGROUND/OBJECTIVE: The term macrosomia is used to describe neonates with a birth weight of 4000 g or more. Macrosomia is a potential risk factor for obesity and metabolic syndromes in postnatal and adult life, yet little is known about its associations with metabolic difference in the early-age. We performed metabolic profiling of umbilical cord blood to discover differential metabolites of macrosomia. METHODS: We conducted a case-control study of full-term singletons with normal maternal glucose tolerance [50 cases (macrosomia, birth weight ⩾4000 g); 50 controls (normal weight, birth weight 2500-3999 g)]...
November 21, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29158541/dysregulation-of-mitochondrial-function-and-biogenesis-modulators-in-adipose-tissue-of-obese-children
#18
R Zamora-Mendoza, H Rosas-Vargas, M T Ramos-Cervantes, P Garcia-Zuniga, H Perez-Lorenzana, P Mendoza-Lorenzo, A Perez-Ortiz, J Estrada, A Miliar-Garcia, E Lara-Padilla, G Ceballos, A Rodriguez, F Villarreal, I Ramirez-Sanchez
BACKGROUND/OBJECTIVES: We aimed to evaluate mitochondrial biogenesis (MB), structure, metabolism, and dysfunction in abdominal adipose tissue from male pediatric patients with obesity. SUBJECTS/METHODS: Samples were collected from five children with obesity (percentile ⩾95) and five eutrophic boys (percentile ⩾5/⩽85) (8-12 years old) following parental informed consent. We analyzed the expression of key genes involved in MB (SIRT1, PPARγ, PGC1α, NRF1, NRF2, and TFAM) and surrogates for mitochondrial function/structure/metabolism (porin, TOMM20, complex I and V, UCP1, UCP2, SIRT3, SOD2) by Western blot...
November 21, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29151597/association-of-plasma-phospholipid-polyunsaturated-and-trans-fatty-acids-with-body-mass-index-results-from-the-multi-ethnic-study-of-atherosclerosis
#19
T A Hastert, M C de Oliveira Otto, F Lê-Scherban, B T Steffen, L M Steffen, M Y Tsai, D R Jacobs, A Baylin
BACKGROUND/OBJECTIVE: Previous research has focused on associations between dietary fat and body mass index (BMI), but the contributions of different types of fat to BMI remain unclear. The purpose of this study is to estimate whether plasma phospholipid omega-3 (n-3), omega-6 (n-6), or trans fatty acids are associated with BMI at baseline and with subsequent BMI changes over time; and whether total phospholipid n-6 or trans fatty acids modify any association between phospholipid n-3 and BMI...
November 20, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29151596/comparison-of-regional-fat-measurements-by-dual-energy-x-ray-absorptiometry-and-conventional-anthropometry-and-their-association-with-markers-of-diabetes-and-cardiovascular-disease-risk
#20
S K Vasan, C Osmond, D Canoy, C Christodoulides, M J Neville, C Di Gravio, C H D Fall, F Karpe
BACKGROUND/OBJECTIVE: Fat distribution is a strong and independent predictor of type 2 diabetes (T2D) and cardiovascular disease (CVD) and is usually determined using conventional anthropometry in epidemiological studies. Dual-energy X-ray absorptiometry (DXA) can measure total and regional adiposity more accurately. Nonetheless, whether DXA provides more precise estimates of cardiovascular risk in relation to total and regional adiposity is not known. We determined the strength of the associations between DXA- and conventional anthropometry determined fat distribution and T2D and CVD risk...
November 20, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
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