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International Journal of Obesity: Journal of the International Association for the Study of Obesity

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https://www.readbyqxmd.com/read/27899810/potential-selection-effects-when-estimating-associations-between-the-infancy-peak-or-adiposity-rebound-and-later-body-mass-index-in-children
#1
C Börnhorst, A Siani, M Tornaritis, D Molnár, L Lissner, S Regber, L Reisch, A De Decker, L A Moreno, W Ahrens, I Pigeot
INTRODUCTION: This study aims to evaluate a potential selection effect caused by exclusion of children with non-identifiable infancy peak (IP) and adiposity rebound (AR) when estimating associations between age and BMI at IP and AR and later weight status. SUBJECTS AND METHODS: In 4 744 children with at least 4 repeated measurements of height and weight in the age interval from 0 to 8 years (37 998 measurements) participating in the IDEFICS/I.Family cohort study, fractional polynomial multi-level models were used to derive individual BMI trajectories...
November 30, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27899809/does-vaginal-delivery-mitigate-or-strengthen-the-intergenerational-association-of-overweight-and-obesity-findings-from-the-boston-birth-cohort
#2
N T Mueller, G Mao, W Bennet, S Hourigan, M G Dominguez-Bello, L J Appel, X Wang
BACKGROUND/OBJECTIVES: The intergenerational association of obesity may be driven by mother-to-newborn transmission of microbiota at birth. Yet Cesarean delivery circumvents newborn acquisition of vaginal microbiota, and has been associated with greater childhood adiposity. Here we examined the independent and joint associations of maternal pre-pregnancy BMI (kg/m(2)) and delivery mode with childhood overweight or obesity. SUBJECTS/METHODS: We prospectively followed 1441 racially and ethnically diverse mother-child dyads in the Boston Birth Cohort until age 5y (range 2...
November 30, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27899808/autoimmunity-to-hsp60-during-diet-induced-obesity-in-mice
#3
M E Şelli, G Wick, D C Wraith, A C Newby
Adaptive immunity has been implicated in adipose tissue inflammation, obesity and its adverse metabolic consequences. No obesity-related autoantigen has yet been identified, although heat shock protein 60 (HSP60) has been implicated in other autoimmune diseases. We investigated whether feeding a high fat diet to C57BL/6J mice would cause autoimmunity to HSP60 and whether immunomodulation with peptides from HSP60 would reverse the resulting obesity or metabolic dysfunction. Obese mice had higher circulating levels of HSP60 associated with increased T-lymphocyte proliferation responses and the emergence of circulating IgG1 and IgG2c antibody levels against HSP60...
November 30, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27899807/does-the-incorporation-of-portion-control-strategies-in-a-behavioral-program-improve-weight-loss-in-a-one-year-randomized-controlled-trial
#4
B J Rolls, L S Roe, B L James, C E Sanchez
BACKGROUND/OBJECTIVES: Controlling food portion sizes can help reduce energy intake, but the effect of different portion-control methods on weight management is not known. In a one-year randomized trial, we tested whether the efficacy of a behavioral weight-loss program was improved by incorporating either of two portion-control strategies instead of standard advice about eating less. SUBJECTS/METHODS: The Portion-Control Strategies Trial included 186 women with obesity (81%) or overweight (19%)...
November 30, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27885270/gdp-per-capita-and-obesity-prevalence-worldwide-an-ambiguity-of-effect-modification-response-to-the-comment-by-prof-torsten-j-selck-does-income-positively-affect-obesity-at-the-macro-level
#5
N A Rybnikova, B A Portnov
International Journal of Obesity accepted article preview online, 25 November 2016. doi:10.1038/ijo.2016.215.
November 25, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27881859/friends-and-social-contexts-as-unshared-environments-a-discordant-sibling-analysis-of-obesity-and-health-related-behaviors-in-young-adolescents
#6
S- Salvy, D M Feda, L H Epstein, J N Roemmich
OBJECTIVE: This study examines the contribution of best friends' weight and the peer social context (time spent alone versus with friends) as sources of unshared environment associated with variability in weight and health behaviors among weight-discordant siblings. METHODS: Pairs of same-sex biologic siblings (N=40 pairs; ages 13-17) were originally recruited as part of a study evaluating putative factors contributing to differences in adiposity among weight-discordant siblings...
November 24, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27881858/safety-and-efficacy-of-bariatric-surgery-in-patients-with-advanced-fibrosis-bariatric-surgery-safety-in-advanced-fibrosis
#7
T Singh, G S Kochhar, G B Goh, P Schauer, S Brethauer, M Kroh, A Aminian, R Lopez, S Dasarathy, A J McCullough
BACKGROUND: Bariatric surgery is performed safely in NAFLD patients with minimal fibrosis (stage 1-2). However, the safety and potential benefits of bariatric surgery for NAFLD with advanced fibrosis (stage 3-4) remain unclear. This study was designed to compare the safety and efficacy of bariatric surgery in patients with biopsy proven advanced fibrosis to those with minimal fibrosis. METHODS: All patients who underwent bariatric surgery between 2005-2014 and had evidence of NAFLD with fibrosis score 3-4 (advanced fibrosis) based on the staging system defined by Kleiner et al...
November 24, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27881857/depressive-symptoms-body-composition-and-bone-mass-in-young-adults-a-prospective-cohort-study
#8
K Zhu, K Allen, J Mountain, S Lye, C Pennell, J P Walsh
BACKGROUND: An association between depression and obesity is well recognised, but longitudinal studies of depressive symptoms in adolescents as a predictor of body composition are lacking. OBJECTIVE: We examined depressive symptoms at age 14, 17 and 20 as predictors of lean, fat and bone mass at age 20 in a birth cohort. SUBJECTS/METHODS: In 1161 participants (569 females) in the Western Australia Pregnancy Cohort (Raine) Study, depressive symptoms were assessed using the Beck Depression Inventory for Youth at age 14 and 17, and the Depression, Anxiety and Stress Scale 21 at age 20...
November 24, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27876761/early-infant-adipose-deposition-is-positively-associated-with-the-n-6-to-n-3-fatty-acid-ratio-in-human-milk-independent-of-maternal-bmi
#9
M C Rudolph, B E Young, D J Lemas, C E Palmer, T L Hernandez, L A Barbour, J E Friedman, N F Krebs, P S MacLean
BACKGROUND/OBJECTIVES: Excessive infant weight gain in the first 6-months of life is a powerful predictor of childhood obesity and related health risks. In mice, omega-6 fatty acids (FA) serve as potent ligands driving adipogenesis during early development. The ratio of omega-6 relative to omega-3 (n-6/n-3) FA in human milk (HM) has increased 3-fold over the last 30 years, but the impact of this shift on infant adipose development remains undetermined. This study investigated how maternal obesity and maternal dietary FA (as reflected in maternal red blood cells (RBC) composition) influenced HM n-6 and n-3 FAs, and whether the HM n-6/n-3 ratio was associated with changes in infant adipose deposition between 2-weeks and 4-months postpartum...
November 23, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27867205/interactive-effects-of-obesity-and-physical-fitness-on-risk-of-ischemic-heart-disease
#10
C Crump, J Sundquist, M A Winkleby, K Sundquist
BACKGROUND/OBJECTIVES: Obesity and low physical fitness are known risk factors for ischemic heart disease (IHD), but their interactive effects are unclear. Elucidation of interactions between these common, modifiable risk factors may help inform more effective preventive strategies. We examined interactive effects of obesity, aerobic fitness, and muscular strength in late adolescence on risk of IHD in adulthood in a large national cohort. SUBJECTS/METHODS: We conducted a national cohort study of all 1 547 407 military conscripts in Sweden during 1969-1997 (97-98% of all 18-year-old males each year)...
November 21, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27867204/a-brief-intervention-for-weight-control-based-on-habit-formation-theory-delivered-through-primary-care-results-from-a-randomised-controlled-trial
#11
R J Beeken, B Leurent, V Vickerstaff, R Wilson, H Croker, S Morris, R Z Omar, I Nazareth, J Wardle
BACKGROUND: Primary care is the 'first port of call' for weight control advice, creating a need for simple, effective interventions that can be delivered without specialist skills. Ten Top Tips (10TT) is a leaflet based on habit-formation theory that could fill this gap. The aim of the current study was to test the hypothesis that 10TT can achieve significantly greater weight loss over three months than 'usual care'. METHODS: A two-arm, individually-randomised, controlled trial in primary care...
November 21, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27867203/epac2a-null-mice-exhibit-obesity-prone-nature-more-susceptible-to-leptin-resistance
#12
M Hwang, Y Go, J-H Park, S-K Shin, S E Song, B-C Oh, S-S Im, I Hwang, Y H Jeon, I-K Lee, S Seino, D-K Song
BACKGROUND: The exchange protein directly activated by cAMP (Epac), which is primarily involved in cAMP signaling, has been known to be essential for controlling body energy metabolism. Epac has two isoforms: Epac1 and Epac2. The function of Epac1 on obesity was unveiled using Epac1 knockout (KO) mice. However, the role of Epac2 in obesity remains unclear. METHODS: To evaluate the role of Epac2 in obesity, we used Epac2a KO mice, which is dominantly expressed in neurons and endocrine tissues...
November 21, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27867202/generalization-and-fine-mapping-of-european-ancestry-based-central-adiposity-variants-in-african-ancestry-populations
#13
S Yoneyama, J Yao, X Guo, L Fernandez-Rhodes, U Lim, J Boston, P Buzková, C S Carlson, I Cheng, B Cochran, R Cooper, G Ehret, M Fornage, J Gong, M Gross, C C Gu, J Haessler, C A Haiman, B Henderson, L A Hindorff, D Houston, M R Irvin, R Jackson, L Kuller, M Leppert, C E Lewis, R Li, L Le Marchand, T C Matise, K-Dh Nguyen, A Chakravarti, J S Pankow, N Pankratz, L Pooler, M D Ritchie, S A Bien, C L Wassel, Y-DI Chen, K D Taylor, M Allison, J I Rotter, P J Schreiner, F Schumacher, L Wilkens, E Boerwinkle, C Kooperberg, U Peters, S Buyske, M Graff, K E North
BACKGROUND/OBJECTIVES: Central adiposity measures such as waist circumference (WC) and waist-to-hip ratio (WHR) are associated with cardiometabolic disorders independently of BMI and are gaining clinically utility. Several studies report genetic variants associated with central adiposity, but most utilize only European ancestry populations. Understanding whether the genetic associations discovered among mainly European descendants are shared with African ancestry populations will help elucidate the biological underpinnings of abdominal fat deposition...
November 21, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27867201/does-body-mass-index-modify-the-association-between-physical-activity-and-screen-time-with-cardio-metabolic-risk-factors-in-adolescents-findings-from-a-countrywide-survey
#14
F V Cureau, U Ekelund, K V Bloch, B D Schaan
BACKGROUND: Moderate and vigorous physical activity (MVPA) and screen time (ST) have been associated with cardio-metabolic health in youth. However, previous studies are conflicting whether these associations are independent of each other and it is unknown if they are modified by adiposity. We aimed to examine the independent and joint associations between MVPA and ST with cardio-metabolic risk across BMI categories. METHODS: A total of 36 956 Brazilian adolescents (12-17 years) from Study of Cardiovascular Risks in Adolescents were included...
November 21, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27857136/differentiating-lipedema-and-dercum-s-disease
#15
K Beltran, K L Herbst
BACKGROUND: People with lipedema or Dercum's disease (DD) can have a similar distribution of excess painful nodular subcutaneous adipose tissue (SAT) making them difficult to differentiate. METHODS: Case series of 94 patients with DD, 160 with lipedema and 18 with both diagnoses (Lip+DD) from a single clinic in an academic medical center to improve identification and differentiation of these disorders by comparison of clinical findings, prevalence of type 2 diabetes (DM2), hypermobility by the Beighton score, and assessment of a marker of inflammation, Total complement activity (CH50)...
November 18, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27847388/30-year-trends-in-overweight-obesity-and-waist-to-height-ratio-by-socioeconomic-status-in-australian-children-1985-to-2015
#16
L L Hardy, S Mihrshahi, J Gale, B A Drayton, A Bauman, J Mitchell
BACKGROUND/OBJECTIVE: To report 30-year (1985-2015) prevalence trends in overweight, obesity and abdominal obesity among children by school level and socioeconomic status (SES). SUBJECTS/METHODS: Five cross-sectional, population child surveys (age 4-18 years; n=27 808) conducted in 1985-1997-2004-2010-2015 in New South Wales, Australia. Outcomes were prevalence of measured overweight, obesity, and waist-to-height ratio (WHtR⩾0.5) by sex, school level (children [primary] and adolescents [high]) and SES tertile...
November 16, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27698346/relevance-of-omental-pericellular-adipose-tissue-collagen-in-the-pathophysiology-of-human-abdominal-obesity-and-related-cardiometabolic-risk
#17
A Michaud, J Tordjman, M Pelletier, Y Liu, S Laforest, S Noël, G Le Naour, C Bouchard, K Clément, A Tchernof
BACKGROUND: Adipose tissue fibrosis is a relatively new notion and its relationship with visceral obesity and cardiometabolic alterations remains unclear, particularly in moderate obesity. OBJECTIVE: Our objective was to examine if total and pericellular collagen accumulation are relevant for the pathophysiology of visceral obesity and related cardiometabolic risk. SUBJECTS AND METHODS: Surgical omental (OM) and subcutaneous (SC) fat samples were obtained in 56 women (age: 47...
November 16, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27686524/renal-cell-carcinoma-survival-and-body-mass-index-a-dose-response-meta-analysis-reveals-another-potential-paradox-within-a-paradox
#18
REVIEW
M Bagheri, J R Speakman, F Shemirani, K Djafarian
BACKGROUND: In healthy subjects increasing body mass index (BMI) leads to greater mortality from a range of causes. Following onset of specific diseases, however, the reverse is often found: called the 'obesity paradox'. But we recently observed the phenomenon called the 'paradox within the paradox' for stroke patients. OBJECTIVE: The objective of our study was to examine the effect of each unit increase in BMI on renal cancer-specific survival (CSS), cancer-specific mortality, overall survival (OS) and overall mortality...
November 16, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27677619/differences-in-brain-functional-connectivity-at-resting-state-in-neonates-born-to-healthy-obese-or-normal-weight-mothers
#19
X Li, A Andres, K Shankar, R T Pivik, C M Glasier, R H Ramakrishnaiah, Y Zhang, T M Badger, X Ou
Recent studies have shown associations between maternal obesity at pre- or early pregnancy and long-term neurodevelopment in children, suggesting in utero effects of maternal obesity on offspring brain development. In this study, we examined whether brain functional connectivity to the prefrontal lobe network is different in newborns from normal-weight or obese mothers. Thirty-four full-term healthy infants from uncomplicated pregnancies were included, with 18 born to normal-weight and 16 born to obese mothers...
November 16, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27430877/neighborhood-socioeconomic-disadvantage-modifies-the-relationship-between-weight-status-and-weight-related-satisfaction
#20
X Feng, A Wilson
Are adults living in disadvantaged communities less likely to recognize or be dissatisfied with being overweight than their counterparts in more affluent areas? Multilevel logistic regression was used to analyze a cross-sectional sample of 10 880 people aged 15 years or older selected from the 2009 wave of the 'Household, Income and Labour Dynamics in Australia'. Outcome variables included whether participants perceived themselves as 'overweight' or not, and their self-reported (dis)satisfaction with their weight...
November 16, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
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