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International Journal of Neuroscience

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March 13, 2018: International Journal of Neuroscience
Sun Qifeng, Zhao Dechun, Cheng Shanshan, Hou Xiaorong, Zhao Xing, Tian Yin
Local field potential of a patient with Parkinson's disease often shows abnormal oscillation phenomenon. Extracting and studying this phenomenon and designing adaptive deep brain stimulation control library have great significance in treatment of patients. This paper has designed a feature extraction method based on modified empirical mode decomposition which extracts the abnormal oscillation signal in the time domain to increase the overall performance. The IMF component which contains abnormal oscillation is extracted by using empirical mode decomposition before an intrinsic characteristic of the oscillation signal is obtained...
March 12, 2018: International Journal of Neuroscience
Zhou Zheng, Xinwei He, Min Zhu, Xiaoping Jin, Cai Li, Feng Zhu, Chenling Lv, Weiling Li, Xiaofei Hu, Wanfeng Wang, Feng Wang
Tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of matrix metalloproteinases that are involved in normal cellular processes and in the development and progression of atherosclerosis. Our purpose was to evaluate the polymorphisms of the TIMP-3 genes for their associations with carotid plaques or with serum protein levels in the Han Chinese population. Two promoter variants, -915A/G (rs2234921) and -1296T/C (rs9619311), were genotyped in 548 subjects with no plaques, 462 subjects with echogenic plaques, and 427 subjects with mixture plaques...
March 2, 2018: International Journal of Neuroscience
Hala A Shaheen, Sayed S Sayed, Lamiaa I Daker, Hossam El Din AbdelAziz, Mohamed A Taha
BACKGROUND: It has been suggested that vitamin D influences the immunoregulation and subsequently affects the risk for conversion of clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (MS). There is little information regarding the relationship between levels of vitamin D and CIS conversion to MS in Egyptian patients. OBJECTIVE: is to study contribution of vitamin D deficiency to conversion of CIS to CDMS and correlation of vitamin D level to cognitive and MRI results...
March 1, 2018: International Journal of Neuroscience
Morgana Novaes, Fernanda Palhano-Fontes, Andre Peres, Kelley Mazzetto-Betti, Maristela Pelicioni, Kátia Andrade, Antonio Santos, Octavio Pontes-Neto, Draulio Araujo
BACKGROUND: Mirror therapy (MT) is becoming an alternative rehabilitation strategy for various conditions, including stroke. Although recent studies suggest the positive benefit of MT in chronic stroke motor recovery, little is known about its neural mechanisms. PURPOSE: To identify functional brain changes induced by a single MT intervention in ischemic stroke survivors, assessed by both Transcranial Magnetic Stimulation (TMS) and functional Magnetic Resonance Imaging (fMRI)...
March 1, 2018: International Journal of Neuroscience
Mohd Aizuddin Mohd Lazaldin, Igor Iezhitsa, Renu Agarwal, Nor Salmah Bakar, Puneet Agarwal, Nafeeza Mohd Ismail
Amyloid-beta (Aβ) is known to contribute to the pathophysiology of retinal neurodegenerative diseases such as glaucoma. Effects of intravitreal Aβ(1-42) on retinal and optic nerve morphology in animal models have widely been studied but not those of Aβ(1-40). Hence, we evaluated the time- and dose-related effects of intravitreal Aβ(1-40) on retinal and optic nerve morphology. Since oxidative stress and brain derived neurotrophic factor (BDNF) are associated with Aβ-induced neuronal damage, we also studied dose and time-related effects of Aβ(1-40) on retinal oxidative stress and BDNF levels...
February 28, 2018: International Journal of Neuroscience
Vahid Azizi, Farzin Allahyari, Abdolkarim Hosseini
AIMS: The genus Buxus grows up widespread in Europe and Western Asia. It is an important traditional plant has been used in the treatment of many illnesses. In the present study, the effect of hydroethanolic extract of Buxus hyrcana Pojark (BHP) on the animal model of seizure was studied. MATERIALS AND METHODS: In this experimental study, forty-two male Wistar rats weighing 220-250 g were randomly selected and were divided into experimental and control groups (6 rats per group)...
February 22, 2018: International Journal of Neuroscience
Valencia Fernandes, Dilip Sharma, Kiran Kalia, Vinod Tiwari
Astrogliosis is a key contributor for many neurological disorders involving apoptosis, neuroinflammation and subsequent neuronal death. Silibinin, a polyphenol isolated from milk thistle (Silybum marianum), has been shown to suppress the astrocyte activation in various neurodegenerative disorders and also exhibit a neuroprotective role in neuroinflammation-driven oxidative damage. In the present study, we found that treatment with silibinin significantly attenuates LPS- oxidative-nitrosative stress in C6 astrocytoma cells...
February 21, 2018: International Journal of Neuroscience
Yue Wu, Xiao-Ni Wang, Ningli Wang, Ying Han, Daqing Ma, Yan Lu
Background We investigated the regularity changes of the retinalnerve fiber layer (RNFL) and macular ganglion cell complex (mGCC) of the amnestic Mild Cognitive Impairment (aMCI) patients in this prospective cohort study. Methods Twenty-four aMCI patients and 30 health controls, who are more than 60 years old, were recruited into the study. The RNFL and the mGCC average thickness were measured with fourier-domain optical coherence tomography (FD-OCT). Results Compared with that in the controls, the intraocular pressure (IOP) was significantly lower in the aMCI patients...
February 15, 2018: International Journal of Neuroscience
Neha Singh, Sheekha Vijayanti, Lekha Saha
Epilepsy is a complex, chronic neurological disorder characterized by increased and abnormal synchronization of neuronal electrical activity, which is manifested as seizures. It is associated with many comorbid conditions such as depression, anxiety, sleep disorder, psychiatric disorder etc. which consequently causes higher mortality rate. The understanding of its cellular and molecular mechanism is partial, because of which it remains an ongoing health problem, despite the increasing availability of newer antiepileptic drugs...
February 15, 2018: International Journal of Neuroscience
José Carlos Arévalo-Lorido, Juana Carretero-Gómez, Nicolás Roberto Robles
BACKGROUND: The relationship between serum uric acid (SUA) levels and stroke is controversial. The discrepancies in the results could be due to the uneven setting of comorbidity. It is known that hyperuricaemia increases in parallel with the decline in renal function; however, there are few studies that adjust for renal disease. AIM: To investigate the relationship between SUA levels in the acute phase of ischaemic stroke according to the presence or absence of chronic kidney disease and clinical outcomes during admission...
February 13, 2018: International Journal of Neuroscience
Chunyu Zhang, Yan She, Tian Lan, Baolige Hu, Guohua Zhang, Juan He, Zhiguang Wang, Mingfang Jiang, Riletemuer Hu
OBJECTIVE: To analyze the prevalence of different degrees vascular cognitive impairment (VCI) in stroke and the characteristics of demography distribution in Inner Mongolia. In order to provide reference data and theoretical guidance for the prevention and treatment of VCI after stroke in the area. METHODS: Stratified multi-stage random sampling was used to extract six regions of Inner Mongolia as the first sampling cluster; and then the corresponding banners (counties) were selected randomly as the secondary sampling cluster; according to the number of patient required to investigation, the corresponding number of communities was randomly selected from the secondary sampling cluster...
February 5, 2018: International Journal of Neuroscience
Saad M Al Shareef, Aljohara S Almeneessier, Richard M Smith, Ahmed S BaHammam
PURPOSE: Kleine-Levin syndrome (KLS) is a rare, relapsing-remitting, debilitating sleep disorder. Examining KLS characteristics in different ethnic populations may help elucidate the genetic basis of the disorder. No studies have examined Kleine-Levin syndrome in Arabs. Therefore, we compared the clinical characteristics of Saudi Arabian KLS patients to those in other published cohorts to determine whether Arab patients have a distinct phenotype. METHODS: This study included all patients who were diagnosed with KLS at our center between June 2003 and July 2016 (P=12;6 familial cases)...
February 3, 2018: International Journal of Neuroscience
Hidir Ozer, Huseyin Bozkurt, Gokan Bozkurt, Murat Demirbilek
OBJECTIVES: A number of chemical and biological factors, including mesenchymal stem cells (MSCs), have been developed to enhance nerve regeneration by introduction through a variety of nerve conduits. This study was designed to assess the efficacy of using chitosan-coated poly-3-hydroxybutyrate (PHB) nerve conduits seeded with human bone marrow-derived MSCs (hMSC-bm) to augment repair in an experimental rat model of sciatic nerve injury. METHODS: A total of 30 rats were randomly assigned to one of three groups (n = 10)...
January 31, 2018: International Journal of Neuroscience
Ebtesam Mohamed Fahmy, Nervana Mohamed Elfayoumy, Ahmed Mohamed Abdelalim, Sahar Abdel-Aaty Sharaf, Rania Shehata Ismail, Haidy Elshebawy
BACKGROUND: Hyperhomocysteinemia, vitamin B12 and folate deficiency have been linked to cognitive dysfunction in multiple sclerosis (MS) patients. OBJECTIVE: This study aimed to investigate the relation of serum homocysteine (Hcy), vitamin B12 and folate to cognitive functions in MS patients. SUBJECTS AND METHODS: Forty-five MS patients and twenty matched healthy controls were included. Subjects were submitted to cognitive assessment using a selected psychometric battery and measurement of serum levels of homocysteine, B12 and folic acid...
January 31, 2018: International Journal of Neuroscience
Miyeoun Song, Maeum Han, Yunhee Kim Kwon
Aucubin (ACB) is an iridoid glycoside with various biological activities. Previously it is reported that ACB reduces cell survival and proliferation in many human tumors, whereas it facilitates cell survival and neuroprotection in damaged neuronal cells and disease models. However, its effects on cell survival in the non-proliferating or differentiated neurons are not known. We examined whether ACB facilitated cell survival in differentiating neural precursor cells, HiB5, compared with the proliferating HiB5 cells at various concentrations...
January 31, 2018: International Journal of Neuroscience
Gaigai Li, Yanyan Li, Yang Hu, Qian Wu, Haihan Yu, Hong Deng, Zhouping Tang
Diffuse low-grade gliomas (LGGs) include WHO grade II diffuse astrocytoma, oligodendroglioma, and oligoastrocytoma. Since the neurological symptoms of LGGs are often subtle and deceptive, LGGs are easily overlooked at their early stage. Here, we report a case of a 49-year-old female with symptoms and imaging manifestations mimicking ischemic infarct. After treatments for ischemic stroke, the symptoms initially fluctuating and then aggravated. In addition, we found that the locations of the lesions did not match the vascular distribution and no obvious abnormalities were observed by Computed Tomography Angiography (CTA) and Transcranial Doppler (TCD)...
January 31, 2018: International Journal of Neuroscience
İlhan Elmaci, Ebru Emekli Alturfan, Salih Cengiz, Aysel Ozpinar, Meric A Altinoz
Cardiac glycosides induce a strong immunological cancer cell cytotoxicity, in which the released intracellular components of dying tumor cells (eg. calreticulin, HMGB1 and ATP) stimulate immunity and help in eradicating cancer. Among the cardiac glycosides, oleandrin is an inhibitor of P-glycoprotein expression and exerts excellent penetration through the blood-brain barrier which also harbours neuroprotective and anti-glioma efficacies. Cardiac glycosides also exert neuroprotective activities, one explanation for such an action is the metabolic arrest as a defense strategy against hypoxia...
January 31, 2018: International Journal of Neuroscience
Ying Sun, Xuehua Shen, Qiubo Li, Qingxia Kong
Baraitser-Winter cerebrofrontofacial syndrome (BWCFF) is a rare autosomal dominant genetic disorder involving multiple organ systems and primarily characterized by structural brain abnormalities and a distinctive facial appearance. It was caused by ACTB and ACTG1 mutations. Here, we describe the case of a 5 and a half-year-old boy with cerebral malformations and epilepsy. Together with ACTB mutation, these findings are diagnostic of BWCFF. We discuss the clinical characteristics, gene types and seizures of Baraitser-Winter Brain Bridge Facial Syndrome (BWCFF)...
January 26, 2018: International Journal of Neuroscience
Qi Liu, Hang Zhang, Jian Xu, Dong Zhao
OBJECTIVES: Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Neuritin is a neurotrophic factor that regulates neural growth and development. However, the role of neuritin in alleviating TBI has not been investigated. METHODS: In this study, Sprague Dawley rats (n = 144) weighing 300 ± 50 g were categorized into control, sham, TBI and TBI + neuritin groups. The neurological scores and the ultrastructure of cortical neurons, apoptotic cells and caspase-3 were measured by using Garcia scoring system, transmission electron microscopy, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling, Western blot analysis and real-time RT-PCR at various time points post-TBI...
January 24, 2018: International Journal of Neuroscience
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