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International Journal of Neuroscience

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https://www.readbyqxmd.com/read/28436759/the-roles-of-micrornas-in-spinal-cord-injury
#1
Zhongju Shi, Hengxing Zhou, Lu Lu, Xueying Li, Zheng Fu, Jun Liu, Yi Kang, Zhijian Wei, Bin Pan, Lu Liu, Xiaohong Kong, Shiqing Feng
BACKGROUND AND PURPOSE: Spinal cord injury (SCI) involves serious damage that can result in abnormal or absent motor and sensory functions and a disruption of autonomic function, and a series of pathological reactions occur after the injury. As a type of small non-coding RNA, microRNAs (miRNAs) have been verified to inhibit gene expression via posttranscriptional regulation. This review mainly focuses on recent advances regarding the roles of miRNAs following SCI. METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were adopted...
April 24, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28385058/postural-sway-in-individuals-with-type-2-diabetes-and-concurrent-benign-paroxysmal-positional-vertigo
#2
Linda D'Silva, Patricia M Kluding, Susan L Whitney, Hongying Dai, Marcio Santos
BACKGROUND AND PURPOSE: Diabetes has been shown to affect the peripheral vestibular end organs and is associated with an increase in the frequency of benign paroxysmal positional vertigo (BPPV). People with diabetes have higher postural sway; however, the impact of symptomatic BPPV on postural sway in individuals with diabetes is unclear. The purpose of this cross-sectional study was to examine postural sway in people with type 2 diabetes who have symptomatic, untreated BPPV (BPPVDM)...
April 6, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28140735/risk-factors-affecting-prognosis-in-infantile-spasm
#3
Gulen Gul Mert, Mihriban Ozlem Herguner, Faruk Incecik, Sakir Altunbasak, Duygu Sahan, Ilker Unal
AIM: To assess risk factors that affect epilepsy prognosis and neurodevelopmental outcome and response to treatment in patients diagnosed with infantile spasm. METHODS: In this study, demographics, treatment modalities, etiologies, risk factors affecting neurodevelopmental outcome and epilepsy prognosis were assessed retrospectively at the end of a minimum 24-months follow-up of 104 patients diagnosed with infantile spasm from May 2012 to October 2015. RESULTS: Neonatal seizure during neonatal period, abnormal head circumference, young age at the time of presentation and early gestational age, symptomatic etiology, abnormal initial examination and abnormal development test at the time of diagnosis, consanguinity, the medical center where treatment was started in the second center or beyond and magnetic resonance imaging finding were found to be statistically significant for poor prognosis in terms of neurodevelopment (p < 0...
March 29, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28332424/neuroprotective-effect-of-dl-3-n-butylphthalide-on-patients-with-radiation-induced-brain-injury-a-clinical-retrospective-cohort-study
#4
Xiaoni Zhang, Yi Li, Xiangpen Li, Xiaoming Rong, Yamei Tang, Ying Peng
PURPOSE: To evaluate the neuroprotective effects of Dl-3-n-butylphthalide (NBP) on patients with radiation-induced brain injury, a hospital-based, clinical retrospective cohort study was conducted. PATIENTS AND METHODS: Data was collected on patients diagnosed with radiation-induced brain injury from January 2009 to January 2015 in Department of Neurology, Sun Yat-Sen Memorial Hospital. All patients enrolled have received cranial radiotherapy and were diagnosed with radiation-induced brain injury...
March 23, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28316267/efficacy-of-a-computer-based-cognitive-training-program-in-older-people-with-subjective-memory-complaints-a-randomized-study
#5
Angela J Pereira-Morales, Andrés F Cruz Salinas, Jairo Aponte Melo, Francisco Pereira Manrique
OBJECTIVE: the aim of this study was to investigate the effect of computer-assisted cognitive training in healthy older adults with subjective memory complaints. METHODS: 40 older adults, mean age (standard Deviation) = 66.4 (5.6) with subjective memory complaints, were included in this study. Participants were randomly assigned to an Integrated Psychostimulation Program (IPP) (N = 17), a Computerized Cognitive Training (CCT) (N = 12) or a control group (N = 11)...
March 20, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28288541/risk-of-subsequent-cancer-among-pediatric-adult-and-elderly-patients-following-a-primary-diagnosis-of-glioblastoma-multiforme-a-population-based-study-of-the-seer-database
#6
Xuezhen Li, Yanbin Li, Yang Cao, Li Peiliang, Bo Liang, Jidian Sun, Enshan Feng
Purpose/aim of the study: Our objective was to determine the risk of a subsequent malignancy in patients with glioblastoma multiforme (GBM). MATERIALS AND METHODS: Data of patients with a primary diagnosis of GBM were extracted from the Surveillance, Epidemiology, and End Results database. Patients were divided into 3 age groups: pediatric, ≤ 19 years of age; adult, 20-59 years; elderly, ≥ 60 years. Outcomes were overall survival and incidence of second cancer. RESULTS: A total of 24,348 patients with primary GBM were identified during the period from 2004-2013; 349 pediatric, 9,841 adults, and 14,518 elderly...
March 14, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28281852/the-patterns-of-eeg-changes-in-early-onset-parkinson-s-disease-patients
#7
Xuetao He, Yuhu Zhang, Jieling Chen, Chunge Xie, Rong Gan, Rong Yang, Limin Wang, Kun Nie, Lijuan Wang
The aim of this study was to investigate the patterns of brain activities changes in early-onset parkinson's disease(EOPD) patients and its relationship with the severity of disease and motor deterioration. Electroencephalography (EEG) was performed in a sample of 52 nondemented EOPD patients and 20 healthy controls with similar age. All patients underwent a battery to assess PD severity and motor deterioration. The EEG data were rated by visual and quantitative analyses with the Grant total EEG(GTE) score and NicoletOne Software...
March 10, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28270030/mean-platelet-volume-platelet-count-ratio-as-a-predictor-of-90-day-outcome-in-large-artery-atherosclerosis-stroke-patients
#8
Weiwei Quan, Zhibo Chen, Xuezhi Yang, Jia Li, Xiang Li, Yiyun Weng, Youyu Li, Xu Zhang
OBJECTIVE: Previous studies reported a lower platelet count (PC) level and a higher mean platelet volume (MPV) level in severe ischemic stroke. We define MPV/PC as the platelet ratio (PR). This study investigates the relationship between PR and 90-day outcome of large artery atherosclerosis (LAA) stroke. MATERIALS AND METHODS: A retrospective analysis was conducted on 338 LAA patients in two hospitals by looking up the electronic medical record (EMR). The 90-day functional outcome was divided into good and poor according to the modified Rankin Scale (mRS) score...
March 7, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28117613/relation-between-serum-leptin-levels-lipid-profiles-and-neurocognitive-deficits-in-chinese-osahs-patients
#9
Yating Peng, Li Zhou, Yuping Cao, Ping Chen, Yan Chen, Dandan Zong, Ruoyun Ouyang
OBJECTIVE: The aim of this study was to compare serum leptin, apolipoprotein A1 (ApoA1), apolipoprotein J (ApoJ) and apolipoprotein H (ApoH) levels in males with obstructive sleep apnea and hypopnea syndrome (OSAHS) to those in healthy control subjects and to examine the possible relation between neurocognitive performance and these factors/serum markers in the subjects. METHODS: In this observational, cross-sectional study, a full-night polysomnography and sensitive neuropsychological assessment were performed on 50 newly diagnosed Chinese male patients and 30 healthy subjects...
February 13, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28110588/neuroprotective-effects-of-adjunctive-treatments-for-acute-stroke-thrombolysis-a-review-of-clinical-evidence
#10
Hongxing Zhou, Suyun Huang, Gavin Sunnassee, Weiyu Guo, Jian Chen, Yang Guo, Sheng Tan
The narrow therapeutic time window and risk of intracranial hemorrhage largely restrict the clinical application of thrombolysis in acute ischemic stroke. Adjunctive treatments added to rt-PA may be beneficial to improve the capacity of neural cell to withstand ischemia, and to reduce the hemorrhage risk as well. This review aims to evaluate the neuroprotective effects of adjunctive treatments in combination with thrombolytic therapy for acute ischemic stroke. Relevant studies were searched in the PubMed, Web of Science and EMBASE database...
February 7, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28102719/pregnancy-and-delivery-in-women-with-spinal-muscular-atrophy
#11
Bakri H Elsheikh, Xiaoli Zhang, Kathryn J Swoboda, Sharon Chelnick, Sandra P Reyna, Stephen J Kolb, John T Kissel
OBJECTIVES: To expand the limited available knowledge about pregnancy and delivery in women with spinal muscular atrophy (SMA) using a cohort of genetically proven SMA patients from USA. METHODS: This was a cross-sectional questionnaire-based study. We mailed questionnaires to 58 women with confirmed SMA. RESULTS: Thirty-two women responded, reporting 35 pregnancies, including 19 women with at least one pregnancy. In this cohort, preterm labor and delivery by cesarean section were more common in mothers with SMA particularly SMA type 2...
February 5, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28100092/sample-size-requirements-for-one-year-treatment-effects-using-deep-gray-matter-volume-from-3t-mri-in-progressive-forms-of-multiple-sclerosis
#12
Gloria Kim, Renxin Chu, Fawad Yousuf, Shahamat Tauhid, Lynn Stazzone, Maria K Houtchens, James M Stankiewicz, Christopher Severson, Dorlan Kimbrough, Francisco J Quintana, Tanuja Chitnis, Howard L Weiner, Brian C Healy, Rohit Bakshi
OBJECTIVE: The subcortical deep gray matter (DGM) develops selective, progressive, and clinically relevant atrophy in progressive forms of multiple sclerosis (PMS). This patient population is the target of active neurotherapeutic development, requiring the availability of outcome measures. We tested a fully automated MRI analysis pipeline to assess DGM atrophy in PMS. DESIGN/METHODS: Consistent 3D T1-weighted high-resolution 3T brain MRI was obtained over one year in 19 consecutive patients with PMS [15 secondary progressive, 4 primary progressive, 53% women, age (mean±SD) 50...
February 2, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28052710/depression-after-stroke-at-12-month-follow-up-a-multicenter-study
#13
Patchara Limampai, Wanpen Wongsrithep, Vilai Kuptniratsaikul
PURPOSE: To study the prevalence of depression at 12 months after stroke and to analyze factors associated with depression. METHODS: This prospective cross-sectional study was conducted among nine tertiary hospitals in Thailand. Stroke patients from the Thai Stroke Rehabilitation Registry who were admitted in inpatient rehabilitation wards were recruited for evaluation at the 12-month follow-up time point. Hospital Anxiety and Depression Scale (HADS) was used to evaluate depression in stroke...
February 2, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28042930/three-versus-seven-days-to-return-to-work-after-mild-traumatic-brain-injury-a-randomized-parallel-group-trial-with-neuropsychological-assessment
#14
Aline M Studerus-Germann, Doortje C Engel, Martin N Stienen, Dieter von Ow, Gerhard Hildebrandt, Oliver P Gautschi
Although most patients with a mild traumatic brain injury (mTBI) recover within days to weeks, some experience persistent physical, cognitive and emotional symptoms, often described as post-concussion syndrome (PCS). The optimal recovery time including return-to-work (RTW) after mTBI is unclear. In this single-centre parallel-group trial, patients assigned three days (3D-group) or seven days (7D-group) sick leave were compared with a comprehensive neuropsychological test battery including the Post-Concussion Symptom Scale (PCSS) within one week, after three and 12 months post-injury...
February 2, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28092225/comparison-of-dysphagia-outcomes-between-rostral-and-caudal-lateral-medullary-infarct-patients
#15
Min Ho Chun, Daeha Kim, Min Cheol Chang
OBJECTIVE: A detailed knowledge of dysphagia outcomes in lateral medullary infarct (LMI) patients would enable proper establishment of swallowing therapy goals and strategies. However, little is known about the impact of infarct location on dysphagia outcomes in patients with LMI. METHODS: Twenty patients with rostral LMI (rostral group) and 20 patients with caudal LMI (caudal group) participated in the study. All patients underwent swallowing therapy, which included compensatory treatments and strengthening exercises, for >3 months...
January 31, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27687579/variants-of-the-elastin-eln-gene-and-susceptibility-to-intracranial-aneurysm-a-synthesis-of-genetic-association-studies-using-a-genetic-model-free-approach
#16
Konstantinos Paterakis, Stelios Koutsias, Chrysoula Doxani, Paraskevi Xanthopoulou, Chrysoula Kokkali, Ioanna Mpoulimari, Maria Tziastoudi, Ioannis Karampelas, Efthimios Dardiotis, Georgios Hadjigeorgiou, Alexandros G Brotis, Elias Zintzaras
BACKGROUND: The presence of an intracranial aneurysm (IA) is thought to have a genetic origin. The genetic association studies (GAS) that investigated the association between IA and elastin gene (ELN) variants have produced contradictory or inconclusive results. MATERIALS AND METHODS: In order to decrease the uncertainty of estimated genetic risk effects, a meta-analysis of published GAS-related variants in the ELN gene (ELN INT20 1315T > C, EX20 1264G > A, INT23 1501 + 24T > C and INT4 196 + 71G > A) with susceptibility to IA was conducted using a genetic model-free approach...
July 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27488466/basilar-artery-hypoplasia-associated-with-changes-of-brainstem-potential-transcranial-doppler-and-perfusion-weighted-imaging
#17
Dao Pei Zhang, Suo Yin, Shu Ling Zhang, Jie Wen Zhang, Qian Kun Ma, Gui Feng Lu
OBJECTIVE: The aim of this study was to observe brainstem hemodynamic alterations associated with basilar artery hypoplasia (BAH). METHODS: Nine hundred and fifty-two consecutive patients received emergency multimodal computed tomography; magnetic resonance imaging and magnetic resonance angiogram during the period of January 2011 to December 2014 were included. The vascular risk factors, brainstem auditory evoked potential (BAEP), blink reflex (BR), transcranial Doppler (TCD) and dynamic susceptibility contrast-enhanced perfusion-weighted imaging were completed...
July 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27485272/antioxidant-status-of-serum-bilirubin-and-uric-acid-in-patients-with-polymyositis-and-dermatomyositis
#18
Zhibo Chen, Zhongqian Su, Wanhui Pang, Yuanyuan Huang, Jie Lin, Zhangna Ding, Senmin Wu, Shunyao Xu, Weiwei Quan, Juzeng Zheng, Huale Chen, Zhengzheng Li, Xiang Li, Jia Li, Yiyun Weng, Xu Zhang
OBJECTIVE: Oxidative stress and variations in antioxidant status are implicated in the pathogenesis of inflammatory and autoimmune diseases. Polymyositis and dermatomyositis (PM/DM) are autoimmune diseases with inflammatory cells infiltrating into skeletal muscles, and the antioxidant status is still controversial. The aim of our study was to investigate the correlation between PM/DM and the antioxidant status of serum bilirubin (Tbil, Dbil and Ibil) and uric acid (UA). MATERIALS AND METHODS: We measured serum concentrations of bilirubin (Tbil, Dbil and Ibil) and uric acid in 384 individuals, including 110 PM/DM patients and 274 healthy controls...
July 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27476523/serum-prealbumin-is-a-predictive-biomarker-for-stroke-associated-infection-after-an-ischemic-stroke
#19
Shan Ye, Shao-Peng Lin, Keping Wu, Yongxiang Fan, Miqing Xu
BACKGROUND: Several prior studies have linked serum prealbumin (PA) as a predictor for perioperative infection. However, whether peripheral blood PA levels can be used as an indicator of stroke-associated infection (SAI) is still unclear. In this study, we attempt to find whether serum PA is a meaningful predictor in SAI after an ischemic stroke, so as to provide theoretical basis for clinical treatment. METHODS: Consecutive patients with acute ischemic stroke who were admitted to our hospital were enrolled and serum PA was collected...
July 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27453334/immediate-memory-and-electrophysiologic-effects-of-prefrontal-cortex-transcranial-direct-current-stimulation-on-neurotypical-individuals-and-individuals-with-chronic-traumatic-brain-injury-a-pilot-study
#20
Therese M O'Neil-Pirozzi, Deniz Doruk, Jennifer M Thomson, Felipe Fregni
Purpose/aim: Memory impairment post-TBI is common, frequently persistent, and functionally debilitating. The purposes of this pilot study were to assess and to compare immediate behavioral auditory working memory and electrophysiologic effects of three different, randomized, conditions of left dorsolateral prefrontal cortex (LDLPFC) transcranial direct current stimulation (tDCS) applied to four neurotypical adults and four adults with chronic traumatic brain injury (TBI). MATERIALS/METHODS: Pre- and post-anodal, cathodal, and sham tDCS auditory memory performance, auditory event-related potentials (P300 amplitude and latency) and power of alpha and theta EEG bands were measured across individuals in each group...
July 2017: International Journal of Neuroscience
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