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International Journal of Neuroscience

Jadranka Miletić, Dunja Drakulić, Snežana Pejić, Marijana Petković, Tihomir V Ilić, Milica Miljković, Aleksandra Stefanović, Milica Prostran, Marina Stojanov
BACKGROUND: Biomarkers of oxidative stress are relevant in the evaluation of the disease status and prooxidant-antioxidant balance, advanced oxidation protein products and lipid peroxidation products (malondialdehyde and 4-hydroxynonenal) are being extensively evaluated regarding their relationship with clinical presentation and disease severity. The aim of study was to evaluate the levels of above mentioned parameters in plasma of 39 men and 17 women with Parkinson's disease, originated from the Republic of Serbia and their relation to clinicopathological characteristics (gender, age at examination, duration of the disease, and Hoehn and Yahr score) and oxidative status...
November 17, 2017: International Journal of Neuroscience
Rosaria De Luca, Margherita Russo, Antonino Naro, Provvidenza Tomasello, Simona Leonardi, Floriana Santamaria, Latella Desireè, Alessia Bramanti, Giuseppe Silvestri, Placido Bramanti, Rocco Salvatore Calabrò
AIM OF THE STUDY: cognitive impairment occurs frequently in post-stroke patients. This study aimed to determine the effects of a virtual reality training (VRT) with BTs-Nirvana (BTsN) on the recovery of cognitive functions in stroke patients, using the Interactive-Semi-Immersive Program (I-SIP). MATERIALS AND METHODS: We enrolled 12 subjects (randomly divided into two groups: experimental group -EG; and control group -CG), who attended the Laboratory of Robotic and Cognitive Rehabilitation of IRCCS Neurolesi of Messina from January to June 2016...
November 17, 2017: International Journal of Neuroscience
Xiaohong Li, Wenchao Li, Xiang Shi, Lijun Mo, Yuzhen Luo, Liuqun Qin, Zheng Yang, Wuning Mo
OBJECTIVE: Our aim was to assess the correlation between serum bilirubin levels and Guillain-Barré Syndrome (GBS). PATIENTS AND METHODS: One hundred and one newly diagnosed patients with GBS and 111 healthy age- and sex-matched individuals in the First Affiliated Hospital of Guangxi Medical University (Guangxi, China) from June 2012 to May 2017 were included in this study. Clinical characteristics and laboratory parameters of GBS patients and healthy controls were retrospectively analysed...
November 13, 2017: International Journal of Neuroscience
Sang-Mi Noh, Hyun Goo Kang
Occipital neuralgia is a common form of headache that is characterized by paroxysmal severe lancinating pain in the occipital nerve distribution. The exact pathophysiology is still not fully understood and occipital neuralgia often develops spontaneously. There are no specific guidelines for evaluation of patients with occipital neuralgia. Cervical spine, spinal cord, and posterior neck muscle lesions can induce occipital neuralgia. Brain and spine imaging may be necessary in some cases, according to the nature of the headache or response to treatment...
November 10, 2017: International Journal of Neuroscience
Cui Wang, Hongliang Xu, Yun Yuan, Yajun Lian, Nanchang Xie, Liang Ming
Kufs disease (KD) type B (also termed CLN13), an adult-onset form of neuronal ceroid lipofuscinosis (NCL), is genetically heterogeneous and challenging to diagnose. Recently, mutations in cathepsin-F (CTSF) have been identified as the causative gene for autosomal recessive KD type B. Here, we report a sporadic case of KD type B with novel compound heterozygous mutations, a novel missense mutation c.977G>T (p.C326F) and a novel nonsense mutation c.416C>A (p.S139X), in the CTSF gene. The magnetic resonance imaging findings were consistent with those demonstrated in adult NCL: diffuse cortical atrophy, mild hyperintensity and reduction of the deep white matter on T2-weighted images...
November 9, 2017: International Journal of Neuroscience
Hai Yuan, Lingling Du, Pingping Ge, Xiaotong Wang, Qing Xia
BACKGROUND: Numerous epidemiological studies were published to investigate the role of Microtubule-Associated Protein Tau (MAPT) gene variations (rs7521G/A, rs242557G/A, rs1467967A/G, rs2471738C/T, and rs3785883G/A) in SAD, and these genetic polymorphisms may be a risk factor for sporadic Alzheimer's disease (SAD). However, controversial results were revealed. METHODS: The MEDLINE, Embase, and HuGEnet databases were searched to identify eligible studies. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the genetic association of MAPT with the risk of SAD...
November 3, 2017: International Journal of Neuroscience
Shewei Guo, Yingwei Zhen, Anran Wang
AIM: Previous studies have demonstrated that geranylgeranylacetone (GGA) exerts neuroprotective effects in experimental ICH. This study is designed to explore the underlying mechanism. MATERIALS AND METHODS: One hundred and eighty male Sprague-Dawley rats were subjected to ICH by stereotactic injection of collagenase and were pretreated without or with different doses of GGA. At 6 h, 24 h, 48 h, 72 h and 7days after the operation, the neurological deficits were examined with the scoring scale method...
November 3, 2017: International Journal of Neuroscience
Lisha Hou, Xudong Du, Longmei Chen, Jijie Li, Peijing Yan, Muke Zhou, Cairong Zhu
BACKGROUND: Quality of life (QoL) post-stroke is an important health outcome. Physical deconditioning and physical inactivity are highly prevalent in stroke survivors. This study aimed to assess the long-term trends in QoL and to explore the effect of exercise on the QoL of ischaemic stroke patients. METHODS: Data for this prospective study were collected at baseline using face-to-face interviews, and telephone follow-ups were completed every 3 months from 2010 through 2014...
November 3, 2017: International Journal of Neuroscience
Eleni de Araújo Sales Castro, Katie Moraes de Almondes
INTRODUCTION: Shift work schedules are biological standpoint worse because compel the body to anticipate periods of wakefulness and sleep and thus eventually cause a disruption of biological rhythms. OBJECTIVE: To evaluate the sleep pattern and decision making in physicians working in mobile units of emergency attention undergoing Day Shift and Rotating Shift. METHODS: The study included 26 physicians. The instruments utilized were a sociodemographic questionnaire, the Pittsburgh Sleep Quality Index (PSQI), the Sleep Habits Questionnaire, the Epworth Sleepiness Scale and Chronotype Identification Questionnaire of Horne-Ostberg, the Iowa Gambling Task (IGT) and hypothetical scenarios of decision-making created according to the Policy-Capturing Technique...
November 3, 2017: International Journal of Neuroscience
Ravinder Bamba, D Colton Riley, Nathaniel D Kelm, Nancy Cardwell, Alonda C Pollins, Ashkan Afshari, Lyly Ngyuen, Richard D Dortch, Wesley P Thayer
BACKGROUND: Conduit-based nerve repairs are commonly used for small nerve gaps, whereas primary repair may be performed if there is no tension on nerve endings. We hypothesize a conduit-based nerve coaptation device will improve nerve repair outcomes by avoiding sutures at the nerve repair site and utilizing the advantages of a conduit-based repair. METHODS: The left sciatic nerves of female Sprague-Dawley rats were transected and repaired using a novel conduit-based device...
November 3, 2017: International Journal of Neuroscience
Jason Gandhi, Janki Shah, Gargi Joshi, Sohrab Vatsia, Andrew DiMatteo, Gunjan Joshi, Noel L Smith, Sardar Ali Khan
Lumbar spinal stenosis (LSS) is characterized by the narrowing of the spinal canal, which subsequently induces impingement of neural elements in the lumbar spine. Thus, symptoms of LSS are typically associated with damage to those neural elements. Herewith, we target the genitourinary symptoms of LSS and the importance of differentiating these symptoms from other genitourinary pathologies, namely benign prostatic hyperplasia. Specifically, we review bladder dysfunction, lower urinary tract symptoms (e.g., urinary incontinence, detrusor overactivity and under-activity, as well as frequent urinary tract infections), renal osteodystrophy, and sexual dysfunction (e...
November 3, 2017: International Journal of Neuroscience
Chih-Tsung Chang, Christina Huang
This paper studies the feasibility of frontal positioning of electrode to detect EEG signals. The proposed method involves placing a reference electrode on the forehead (Fp2) to examine visually evoked potential (VEP) signals instead of the mid-occipital electrode location (Oz) used in the traditional measurement methods. We employed widely used VEP methods, including steady-state VEP (SSVEP), flash VEP (FVEP) and Phase to investigate and compare the brain wave signals from both the Oz and Fp2 position. Traditional measurement at the Oz location are limited because of the interference from human hair, and an additional electrode is required to detect eye movement and filter this Electro-Oculogram (EOG) signal...
November 3, 2017: International Journal of Neuroscience
Yun Zhang, Zhonglun Chen, Yufeng Tang, Wanying Shan, Ling Wang, Jian Shi, Qian Luo, Jinfeng Duan, Gelin Xu
BACKGROUND AND PURPOSES: Procalcitonin has been suggested as a new risk factor in atherosclerotic disease. However, whether procalcitonin levels are associated with the risk of carotid atherosclerosis remains unclear. This study aimed to investigate the relationship between procalcitonin levels and carotid atherosclerosis among patients with first-ever acute ischemic stroke. METHODS: Two hundred and thirty consecutive patients were prospectively enrolled in this study...
November 3, 2017: International Journal of Neuroscience
I Berkiks, H Benmhammed, A Mesfioui, A Elhasnaoui, S Mouden, T Touil, Y Bahbiti, R Nakache, A Ouichou, A El Hessni
Systemic inflammation induced by neonatal infection may result as long-term hyperactivation of microglial cells followed by an overproduction of pro-inflammatory cytokines, such as tumor necrosis factor (TNF-α), nitric oxide (NO), and lipid peroxidation. Those inflammation mediators can trigger behavioral disruption and/or cognitive disorders. The present work aims to evaluate the effect of melatonin (a cytokine release modulator and antioxidant agent) in the reduction of the prefrontal microglia activation and depressive-like behaviors induced by LPS injection in adult rats...
October 27, 2017: International Journal of Neuroscience
Bo Sun, Yifan Li, Lizhi Liu, Zhaohui Chen, Li Ling, Fei Yang, Jiexiao Liu, Hong Liu, Xusheng Huang
INTRODUCTION: To date, there are no validated screening scales for small fiber neuropathy (SFN). This study investigated the Small-Fiber Neuropathy and Symptom Inventory Questionnaire (SFN-SIQ) as well as the Small Fiber Neuropathy Screening List (SFNSL) for SFN diagnosis. METHODS: Fifty-five patients were divided into SFN and mixed fiber damage groups. Relevant scales, nerve conduction studies (NCS) and skin biopsies were performed. Relationships between the intraepidermal nerve fiber density (IENFD) and different scales as well as the diagnostic and cut-off values (score at which Youden's index is largest) were determined...
October 27, 2017: International Journal of Neuroscience
Ye Jiang, Jie Lao
Phrenic nerve transfer has been a well-established procedure for restoring elbow flexion function in patients with brachial plexus avulsion injury. Concerning about probably detrimental respiratory effects brought by the operation, however, stirred up quite a bit of controversy. We present a case report of the successful application of phrenic nerve as donor to reinnervate the biceps in a septuagenarian with brachial plexus avulsion injury, not accompanied with significant clinical respiratory problem.
October 27, 2017: International Journal of Neuroscience
Sutapa Som Chaudhury, Chitrangada Das Mukhopadhyay
Misfolded β-sheet structures of proteins leading to neurodegenerative diseases like Alzheimer's (AD) and Parkinson's diseases (PD) are in the spotlight since long. However, not much was known about the functional amyloids till the last decade. Researchers have become increasingly more concerned with the degree of involvement of these functional amyloids in human physiology. Interestingly, it has been found that the human body is exposed to a tremendous systemic amyloid burden, especially, during aging. Though many findings regarding these functional amyloids come up every day, some questions still remain unanswered like do these functional amyloids directly involve in the fibrillization of Amyloid beta (Aβ) 42 peptide or enhance the Aβ42 aggregation rate; whether functional bacterial amyloids (FuBA) co-localize with the senile plaques of AD or not...
October 27, 2017: International Journal of Neuroscience
Tomoyuki Ueno, Yasushi Hada, Yukiyo Shimizu, Thoru Yamada
PURPOSE: The somatosensory event-related potential N140 is thought to be related to selective attention. This study aimed to compare the somatosensory event-related potential N140 in healthy subjects to that in patients with stroke to determine whether N140 and attentiveness are associated in patients with stroke with or without hemispatial agnosia. MATERIALS AND METHODS: Normal somatosensory event-related potential N140 values were determined using data from ten healthy subjects...
October 27, 2017: International Journal of Neuroscience
Weiwei Quan, Junhui Xia, Qiuling Tong, Jie Lin, Xiaolu Zheng, Xuezhi Yang, Dewei Xie, Yiyun Weng, Xu Zhang
We reported a misdiagnosed case of a 66-year-old man who concomitantly developed chronic inflammatory demyelinating polyneuropathy (CIDP) and myasthenia gravis (MG), which was rarely reported. This man presented with chronic progressive sensory symptoms, flaccid tetraparesis, areflexia and protein-cell dissociation of cerebrospinal fluid. Nerve conduction study was indicative of demyelinating neuropathy. He was suspected as CIDP and treated with high-dose glucocorticoids. However, his condition worsened. Four months later, he was admitted and was diagnosed as combination of CIDP and MG...
October 27, 2017: International Journal of Neuroscience
Kunting Zhu, Qi He, Lingyu Li, Yong Zhao, Jing Zhao
Induction of endogenous antioxidants is one of the key molecular mechanisms of cell resistance to hypoxia/ischemia. Thioredoxin1 (Trx1) is a small multifunctional ubiquitous antioxidant with redox-active dithiol and plays an important role in cell apoptosis through mitochondrial apoptosis pathways. The specific role of Trx1 in ischemia-reperfusion induced astrocyte apoptosis, however, remains unclear. In this study, we investigated the effect of Trx1 on apoptosis of astrocyte using an in vitro oxygen-glucose deprivation/reoxygenation (OGD/R) model which mimics ischemic/reperfusion conditions in vivo...
October 27, 2017: International Journal of Neuroscience
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