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International Journal of Neuroscience

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https://www.readbyqxmd.com/read/28918695/large-animal-models-of-traumatic-brain-injury
#1
Jun-Xi Dai, Yan-Bin Ma, Nan-Yang Le, Jun Cao, Yang Wang
Traumatic brain injury (TBI) is a devastating and common health problem in today's society. Relevant animal models of TBI provide powerful tools to study TBI in a controlled, rigorous and cost-efficient manner. The mostly used animals in TBI studies so far are rodents, however, huge inter-species differences in anatomy, morphology, metabolism, neurobiology, and lifespan between rodents and humans have impeded the translation of research findings from labs to human. Compared with rodents, large animals (eg. swine, rabbit, sheep, ferret) show great advantages in modelling TBI due to the similarity of their brains to human brain...
September 18, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28918694/brain-metabolic-correlates-of-fatigue-in-parkinson-s-disease-a-pet-study
#2
Li Zhang, Tiannv Li, Yongsheng Yuan, Qing Tong, Siming Jiang, Min Wang, Jianwei Wang, Jian Ding, Qinrong Xu, Kezhong Zhang
The neural bases of fatigue in Parkinson's disease (PD) remain uncertain. We aimed to assess the brain metabolic correlates of fatigue in patients with PD. Twenty-seven PD patients without clinically relevant depression (17-item Hamilton Depression Rating Scale [HAMD] score ≥ 14), apathy (Apathy Scale [AS] score ≥ 14) and excessive daytime somnolence (Epworth Sleepiness Scale [ESS] score ≥ 10) were evaluated with Fatigue Severity Scale (FSS). Each patient had an F-18 fluorodeoxyglucose PET (FDG-PET) scan...
September 18, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28918684/differential-induction-of-c-fos-and-phosphorylated-erk-by-a-noxious-stimulus-after-peripheral-nerve-injury
#3
Mitsuyasu Tabata, Ryuji Terayama, Kotaro Maruhama, Seiji Iida, Tomosada Sugimoto
Induction of c-Fos and phosphorylated extracellular signal-regulated kinase (p-ERK) has been demonstrated in spinal dorsal horn neurons by noxious stimuli. In this study, we compared induction of c-Fos and p-ERK in the spinal dorsal horn after peripheral nerve injury. We examined the spinal dorsal horn for noxious heat-induced c-Fos and p-ERK protein-like immunoreactive (c-Fos- and p-ERK-IR) neuron profiles after tibial nerve injury. A large number of c-Fos- and p-ERK-IR neuron profiles were induced by noxious heat stimulation to the hindpaw in sham-operated animals...
September 18, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28918680/transcranial-direct-current-stimulation-in-disorders-of-consciousness-a-review
#4
Ye Zhang, Weiqun Song
It is a challenge to evaluate and treat the patients with disorders of consciousness (DOC) in the clinic. Due to the huge costs of prolonged intensive care, the management of these patients raises great financial strain on families and important ethical questions. To date, several studies have attempted to specifically detect pharmacologic or non-pharmacologic effectiveness, until now there were no evidence-based guidelines about the treatment of patients with DOC. Recently, because of ethical and procedural limitations on the use of invasive stimulation techniques, non-invasive brain stimulation, such as the transcranial direct current stimulation (tDCS), has been investigated for improving the level of consciousness in patients with DOC...
September 18, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28920508/internal-carotid-artery-dissection-among-younger-and-older-patients-with-acute-ischemic-stroke
#5
Y Amsalem, L Porat, M C Javitt, E Sprecher, G Telman
BACKGROUND: Carotid artery dissection (CAD) is a known causative factor in the etiology of acute ischemic stroke in young patients. However, the significance of CAD in older patients with acute ischemic stroke is unclear with only a few prior clinical studies. In order to isolate the influence of CAD as an independent factor, we performed multivariate analysis of common covariables in acute ischemic stroke patients in northern Israel. PATIENTS AND METHODS: 347 consecutive patients who suffered from acute ischemic stroke had initial CT angiography (CTA) ordered from the emergency room...
September 16, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28914566/a-novel-etfdh-mutation-in-an-adult-patient-with-late-onset-riboflavin-responsive-multiple-acyl-coa-dehydrogenase-deficiency
#6
Min Chen, Jing Peng, Wei Wei, Wang, Hongliang Xu, Hongbo Liu
We report a novel mutation in the electron transfer flavoprotein dehydrogenase (ETFDH) gene in an adult patient with late-onset riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency (MADD) characterized by muscle weakness and hypoglycemia as main clinical presentation. At the age of 34 years, the patient experienced progressive muscle weakness and short of breath. Blood creatine kinase level was significantly higher than normal. The blood glucose was significantly lower than normal. The muscle biopsy revealed lipid storage myopathy...
September 15, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28914554/when-cooperation-goes-wrong-brain-and-behavioral-correlates-of-ineffective-joint-strategies-in-dyads
#7
Michela Balconi, Laura Gatti, Maria Elide Vanutelli
Human life is connoted by sophisticated interactions that involve not only single individuals, but larger social groups composed by members interacting each other. Cooperation secures a benefit to all the people engaged as well as important behaviors like helping, sharing, and acting prosocially. But what happens when the joint actions are not effective? In the present study we asked 24 participants paired in 12 dyads to cooperate during an attentional task in a way to synchronize their responses and obtain better outcomes...
September 15, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28911255/downward-finger-displacement-distinguishes-parkinson-disease-dementia-from-alzheimer-disease
#8
Abraham Lieberman, Aman Deep, Jiong Shi, Rohit Dhall, Saulena Shafer, Guillermo Moguel-Cobos, Ravneet Dhillon, Christopher W Frames, Margaret McCauley
Purpose/Aim of the study: To study finger displacement in patients with Parkinson disease dementia (PDD) and in patients with Alzheimer disease (AD). METHODS: We examined 56 patients with PDD and 35 with AD. Patients were examined during their regular outpatient clinic visit. Finger displacement was measured by observers not actively involved in the study using a creative grid ruler for all PDD and AD patients. Finger displacement was examined by asking patients to point their index fingers toward the grid ruler with the nails facing upward...
September 15, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28903615/a-study-of-oxidative-stress-in-migraine-with-special-reference-to-prophylactic-therapy
#9
Gyanesh M Tripathi, Jayantee Kalita, Usha K Misra
OBJECTIVE: This study has been undertaken to evaluate the role of oxidative stress markers in migraine and effect of treatment on these markers. SUBJECT AND METHODS: 150 patients having more than 4 attacks of migraine headache per month were included.Headache severity was determined by Migraine Index (MI) and Frequency of headache was noted. 120 patients received rTMS therapy and 30 patients received AMT daily Recovery was defined by 50% improvement in frequency or severity or reduction in MI...
September 14, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28893124/the-burden-of-non-symptomatic-cerebral-ischemia-on-mri-and-its-effect-on-clinical-outcomes-in-patients-with-first-ever-intracerebral-hemorrhage
#10
Mangmang Xu, Shihong Zhang, Jiaqi Liu, Simiao Wu, Ruozhen Yuan, Ming Liu
PURPOSE: To compare the burden of non-symptomatic cerebral ischemia (NSCI) detected on magnetic resonance imaging (MRI) and computed tomography (CT), and assess the association of MRI-NSCI with clinical outcomes among patients with first-ever intracerebral hemorrhage (ICH). METHODS: 2305 consecutive ICH patients admitted to our institution from May 2012 to October 2015 were retrospectively reviewed. Data on clinical characteristics and MRI/CT scans were collected during hospitalization...
September 12, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28889789/blood-pressure-evolution-in-young-patients-with-acute-ischemic-stroke-a-new-model-for-understanding-the-natural-course-of-spontaneous-hypertension
#11
Pablo Bonardo, Fatima Pantiu, Anibal Chertcoff, Luciana Leon Cejas, Sol Pacha, Claudia Uribe Roca, Glenda Ernst, Manuel Fernandez Pardal, Ricardo Reisin
BACKGROUND: Approximately 80% of patients suffering an acute ischemic stroke develop transient hypertension. The physiopathological mechanism remains unclear. Due to the lack of vascular risk factors, young adults could be a useful model for understanding blood pressure (BP) evolution in this setting. METHODS: Patients between 18-55 years old admitted with an acute ischemic stroke were included. BP was evaluated during the following 48 h. Hypertension was defined as: systolic blood pressure (SBP) ≥ 140 mmHg or diastolic blood pressure (DBP) ≥ 90 mmHg...
September 9, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28882090/stenosis-length-of-middle-cerebral-artery-and-branch-atheromatous-disease-associated-infarct
#12
Jian Wang, Yujie Wang, Zijia Chai, Yue Xin, Jialiang Wang, Jianting Qiu
ABSRACT Background: We analyzed the relationship between the characteristics of branch atheromatous disease associated infarct (BAI) and stenosis length (SL) of relevant middle cerebral artery (MCA) M1 segment. METHODS: 95 patients with BAI were recruited from 1024 consecutive acute ischemic stroke patients. Among them, 59 patients (62.11%) had concurrent relative stenosis of MCA M1 segment. The neurologic deficit severity at admission was assessed by NIHSS and the infarct size by infarct lesion thickness and maximum diameter...
September 8, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28881164/systemic-rosai-dorfman-disease-with-central-nervous-system-involvement
#13
Song Tan, Lunliang Ruan, Kai Jin, Fuchao Wang, Jiamin Mou, Hua Huang, Gang Yang
Rosai-Dorfman disease (RDD) is a rare idiopathic and lymphoproliferative disorder. Central nervous system (CNS) involvement is infrequent and typically manifests as an isolated lesion. In this article we describe an unusual case of RDD with multiple lesions in the CNS, upper respiratory tract, and lymph nodes. A literature review revealed 45 cases (including the one described herein) of systemic RDD with CNS involvement documented to date. Among these cases, 29 (64.4%) presented with intracranial lesions, ten (22...
September 7, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28877638/spinocerebellar-ataxia-a-critical-review-of-cognitive-and-socio-cognitive-deficits
#14
Flora Giocondo, Giuseppe Curcio
The primary aim of this contribution is to provide a critical discussion on cognitive and socio-cognitive implications of spinocerebellar ataxias (SCA) subtypes. The term SCA refers to a group of neurodegenerative disorders that have been increasingly investigated in the last years, sharing the characteristic of progressive ataxia resulting from degeneration of cerebellum and its connections. In past decades only involvement of cerebellum in behaviour and timing have been investigated, bringing to the belief about its central role in timing of movement and sensation, particularly for short intervals of time...
September 7, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28866949/annexin-a10-contributes-to-chronic-constrictive-injury-induced-pain-through-activating-erk1-2-signaling-in-rats
#15
Feng Li, Zhou-Ya Xue, Xiang Liu, Gang Bai, Yuan-Lin Wang
PURPOSE: The current study aims at investigating the downstream targets of spinal Annexin A10 (ANXA10) in modulating neuropathic pain. MATERIALS AND METHODS: Paw withdrawal latency (PWL) and paw withdrawal threshold (PWT) were measured to evaluate the pain-associated behavior in rats. The expression of spinal ANXA10, phosphorylated-extracellular regulated kinase 1/2 (p-ERK1/2), and extracellular regulated kinase (ERK1/2) were detected by western blotting. The level of tumor necrosis factor-α (TNF-α) and Interleukine-1β (IL-1β) was tested by ELISA kits...
September 3, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28858532/tinnitus-still-a-ghost-in-the-machine-or-a-darwinian-survival-phenomenon
#16
Sylvester Fernandes
INTRODUCTION: The causation of tinnitus continues to intrigue. Despite the plethora of publications there is no definitive path available to concentrate our efforts, in alleviating the symptom. Several mechanical theories are available in standard tinnitus literature with varying empiricism. OBJECTIVES: To investigate a possible way forward. MATERIALS AND METHODS: Employing a forensic methodology ("crime scene analysis" technique) and utilising available evidence from the related sciences, inductive and abstract reasoning, a pragmatic model incorporating the known features of tinnitus is available...
August 31, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28849724/molecular-genetic-diagnostics-of-von-hippel-lindau-syndrome-vhl-in-bulgaria-first-complex-mutation-event-in-the-vhl-gene
#17
Maria Glushkova, Petia Dimova, Iglika Yordanova, Tihomir Todorov, Ivan Tourtourikov, Vanyo Mitev, Albena Todorova
Von Hippel-Lindau syndrome (VHL) is an autosomal-dominant disease characterized by the formation of various tumors and cysts in many different parts of the body. VHL is caused by VHL gene mutations leading to production of impaired tumor suppressor VHL protein or its complete absence. We studied five patients with clinically suspected VHL, who were referred for molecular genetic testing. The sequence analysis of the coding regions of the VHL gene revealed five clinically relevant germline mutations. One of the pathogenic variants has not been previously reported...
August 29, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28830290/emergent-loading-dose-of-antiplatelets-for-stenting-after-iv-rt-pa-in-acute-ischemic-stroke-a-feasibility-study
#18
Yun-Fei Han, Qi-Liang Dai, Xiang-Liang Chen, Yun-Yun Xiong, Qin-Yin, Ge-Lin Xu, Wu-Sheng Zhu, Ren-Liang Zhang, Min-Min Ma, Wen-Hua Liu, Xin-Feng Liu
BACKGROUND: A loading dose of antiplatelets reduces in-stent thrombosis after stent implantation. However, whether it is safe in patients undergoing acute stenting after intravenous recombinant tissue plasminogen activator (rt-PA) is unclear. METHODS: A case series of acute ischemic stroke patients treated with intravenous rt-PA followed by emergent stenting were prospectively included in Jinling Hospital Stroke Unit. An emergent loading dose of antiplatelets (aspirin 300mg and clopidogrel 300mg) were administered to all patients through a nasogastric tube immediately before stenting...
August 23, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28803490/parkin-pink1-and-dj1-as-possible-modulators-of-mtor-pathway-in-ganglioglioma
#19
Katarzyna Drapalo, Jaroslaw Jozwiak
Ganglioglioma (GG) is a non-malignant tumor classified as G1 by the WHO. Although we currently know that the neoplasm may result from the hyperactivity of protein kinase B (PKB or Akt) or extracellular-regulated kinase (Erk), which upregulates mammalian target of rapamycin kinase (mTOR) and leads to translation of proteins responsible for cell cycle regulation, there are still many questions to be answered. In the current paper we try to analyze the link between GG formation and activity of three proteins known to play a role in neuroprotection...
August 14, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28803488/clinical-outcome-and-predictive-factors-of-postoperative-myasthenic-crisis-in-173-thymomatous-myasthenia-gravis-patients-myasthenic-crisis-in-thymomatous-patients
#20
Yan Li, Haiyan Wang, Pei Chen, Zhenguang Chen, Chunhua Su, Chuanming Luo, Huiyu Feng, Weibin Liu
PURPOSE: Thymectomy is the first-line therapy for thymomatous myasthenia gravis patients. The aim of this study is to explore the clinical outcome and predictors of postoperative myasthenic crisis (POMC) in these patients. METHOD: Clinical data of 173 thymomatous myasthenia gravis patients undergoing thymectomy from January 2000 to March 2013 were retrospectively reviewed. Variables potentially affecting the occurrence of POMC were evaluated using binary logistic regression analysis...
August 14, 2017: International Journal of Neuroscience
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