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International Journal of Neuroscience

Chao Liu, Kaixuan Liu, Lei Chu, Liang Chen, Zhongliang Deng
of Background Data. The optimal PECD surgical approach for CIVDH remains controversial.
The conventional posterior K-hole approach for PECD leads to damage of facet joint. OBJECTIVES: This paper is to first describe a novel posterior lamina-hole approach of percutaneous endoscopic cervical discectomy for cervical intervertebral disc herniation(CIVDH). To evaluate the feasibility and short-term clinical effect of this approach. METHODS: Single-center retrospective observational study of all patients managed with PPECD using the lamina-hole approach for symptomatic single-level CIVDH between January 2015 and January 2016...
September 21, 2018: International Journal of Neuroscience
Siddika Halicioglu, Sule Aydin Turkoglu
OBJECTIVE: Multiple sclerosis (MS) is a demyelinating autoimmune disease of the central nervous system. T2W-hyperintense demyelinating lesions are detected in cranial magnetic resonance imaging (MRI). Developmental venous anomalies (DVAs) have frequently been detected in enhanced cranial MRI images, and are generally accepted as normal variants of venous development. The aim of the present study was to investigate whether there was an association between demyelinating diseases and venous anomalies...
September 21, 2018: International Journal of Neuroscience
Ioannis Mavroudis, Foivos Petridis, Dimitrios Kazis
BACKGROUND: Sporadic inclusion body myositis is the most common inflammatory myopathy over the age of 50. The aetiopathogenesis of the disease remains unclear and to the day there is no effective treatment. OBJECTIVES: The aim of the present review is to present the latest data on the new insights and developments in the treatment of sporadic inclusion body myositis, focusing on Bimagrumab and Alemtuzumab. METHODS: For the purpose of the review we searched multiple internet databases in order to find the most recent studies and clinical trials on the safety, tolerability and efficacy of Bimagrumab and Alemtuzumab in sporadic inclusion body myositis...
September 21, 2018: International Journal of Neuroscience
Amal Chandra Mondal, Mahino Fatima
Depression is one of the most prevalent, recurrent and life-threatening mental illnesses. However, the precise mechanism underlying the disorder is not understood yet. It is therefore, essential to identify the symptoms and then discover the novel biomarkers which will help in the diagnosis and the development of effective treatment. In this milieu, number of preclinical and clinical studies suggest that several neurotrophic factors, including the brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) play an important role in the pathophysiology of major depression...
September 21, 2018: International Journal of Neuroscience
Xiaoyu Dong, Fang Ba, Ruihua Wang, Dongming Zheng
BACKGROUND: The abuse of nitrous oxide (N2 O) can induce Vitamin B12 deficiency that subsequently leads to central nervous demyelination, myelopathy and peripheral neuropathy. Although myelopathy has been reported in the past, the specific locations and prognosis of the disease are still unclear. METHODS: We report the case of a 22-year-old male who presented with quadriplegia that began after a 3-month history of inhalation of N2 O. We summarized the clinical data of this entity and performed a comprehensive literature review of various presentations and MRI features of myelopathy secondary to N2 O abuse...
September 20, 2018: International Journal of Neuroscience
Ruth T Morin, Bradley N Axelrod, Summar Reslan, Christian Schutte
AIMS: In neuropsychological evaluations, it is often difficult to ascertain whether poor performance on measures of validity is due to poor effort or malingering, or whether there is genuine cognitive impairment. Dunham and Denney [1] created an algorithm to assess this question using the Medical Symptom Validity Test (MSVT). We assessed the ability of their algorithm to detect poor validity vs. probable impairment, and concordance of failure on the MSVT with other freestanding tests of performance validity...
September 20, 2018: International Journal of Neuroscience
Niyousha Alizadeh, Nasim Nosrat, Zohreh Jahani, Abolhassan Ahmadiani, Sareh Asadi, Jamal Shams
OBJECTIVE: There have been controversial results in the literature on the association between HTR1A polymorphisms (rs10042486, C-1019G, and Gly272Asp) and obsessive-compulsive disorder (OCD). Here, the plausibility for such genetic and pharmacogenetic association was investigated by assessing a sample of Iranian OCD patients. METHOD: OCD patients had fulfilled the criteria for DSM-IV-TR with Y-BOCS scores higher than 9. A total of 207 controls and 205 patients' blood samples were genotyped by means of PCR-RFLP...
September 20, 2018: International Journal of Neuroscience
Hirotomo Ten, Koji Adachi, Fumio Yamaguchi, Akira Matsuno, Akira Teramoto, Akio Morita
Schwannoma arising within brain parenchyma is a rare scenario. So far, only 70 cases were reported. We reported a case of intracerebral schwannoma presented with occipital lobe epilepsy, which has never been reported before. A 19-year-old man suffered from intermittent blurred vision and headache. Neuroradiological findings showed a left occipital lesion with cystic and solid components. Histological and electron micrograph features confirmed the diagnosis of schwannoma after the tumor was totally removed. The theories and literature related to this case were reviewed and the possible developmental origin was discussed...
September 20, 2018: International Journal of Neuroscience
Ahmed S Hisab
INTRODUCTION: Elevation in the level of intracellular cAMP is known to induce astrocytic differentiation of C6 glioma cells by unknown mechanisms. METHODS: Therefore, cytoskeletal protein genes (phalloidin) fluorescents to investigate morphological changes, cell proliferation assay, MTT assay, flow cytometry, western blotting, in-cell western, immune-cytochemical (Protein expression and localization) and oxygen electrodes (Oxygen consumption rate) after a treatment with 0...
September 20, 2018: International Journal of Neuroscience
Fan Lou, Ming Li, Na Liu, Xiaohong Li, Yan Ren, Xiaoguang Luo
PURPOSE: To explore the potential association between the single-nucleotide polymorphism of two functional genes (SREBF1gene rs11868035 and USP25 gene rs2823357) and susceptibility to Parkinson's disease (PD) in people of Northeast China. METHODS: 649 cases of Parkinson's disease from consecutive outpatient and inpatient ward of our hospital were included in this retrospective study, and 355 healthy people were also included as control group. The technique of Kompetitive Allele Specific PCR (KASP) was applied to determine the frequency distribution of genotype and allele gene of rs11868035 and rs2823357 in both groups...
September 20, 2018: International Journal of Neuroscience
Bina Kumari Mehta, Kaushal Kumar Singh, Sugato Banerjee
Type 2 Diabetes (T2D) associated cognitive impairment is highly prevalent especially among the geriatric population. Here we investigate the role of exercise in T2D associated cognitive decline in rats. T2D was induced using high fat diet (15 days) followed by low dose STZ (25mg/kg). The T2D animals were subjected to aerobic exercise on running wheel for 6 weeks. Effect of aerobic exercise on cognitive performance of T2D animals was measured using step down and transfer latency tests. This was followed by measurement of reduced glutathione levels in corticohippocampal lysates...
September 19, 2018: International Journal of Neuroscience
Jianati Anniwaer, Meng-Zhuang Liu, Ke-Dong Xue, Abuduzhayier Maimaiti, Aersilan Xiamixiding
PURPOSE: Although hyperhomocysteinemia (Hhcy) is a risk factor for cerebral infarction, its effect on recurrent cerebral infarction is less-defined. We aimed to investigate the association of Hhcy and increased risk of recurrent cerebral infarct. MATERIALS AND METHODS: From 2011-2013, we recruited 231 primary cerebral infarct patients that were divided to a Hhcy group (n = 105) and a control group (n = 126) according to plasma homocysteinemia (Hcy) levels exceeding 15μmol/L...
September 14, 2018: International Journal of Neuroscience
Jolana Markovà, Ute Essner, Bülent Akmaz, Marcella Marinelli, Christiane Trompke, Arnd Lentschat, Carlos Vila
Purpose/aim: To evaluate the efficacy of tetrahydrocannabinol (THC):cannabidiol (CBD) oromucosal spray (Sativex® ) as add-on therapy to optimised standard antispasticity treatment in patients with moderate to severe multiple sclerosis (MS) spasticity. METHODS: Sativex® as add-on therapy vs. further optimised first-line ANTispastics (SAVANT) was a two-phase trial. In Phase A, eligible patients received add-on THC:CBD spray for 4 weeks to identify initial responders [≥20% improvement from baseline in spasticity 0-10 numerical rating scale (NRS) score]...
September 13, 2018: International Journal of Neuroscience
Ning-Ning Hu, Man-Man Zhang, Yan-Yan Chen, Bei-Lei Zhu
Primary central nervous system lymphoma, a rare primary intracranial tumor, is highly malignant and usually associated with poor prognosis. Recent years, owing to the remarkable progress in intervention techniques, survival time reported has been significantly prolonged. Strategies targeting alleviation and remission are primarily depended on the early diagnosis. However, due to the heterogeneity of the clinical symptoms and imaging features, the disease is frequently misdiagnosed especially in the early phase, rendering a delay of optimal treatment...
September 12, 2018: International Journal of Neuroscience
Abhai Kumar, Smita Singh, Anup Singh, Ashish Verma, Vijay Nath Mishra
Mild cognitive impairment (MCI) is an early stage of dementia. The changes in white matter integrity and antioxidant enzymes levels are crucial in onset and progression to Alzheimer's disease (AD). To elucidate the changes in cognitive performance, white matter integrity, oxidative stress marker, for early detection of prodromal state of AD. Fifty cases of MCI and controls (55-75 years) were subjected to Mini Mental State Examination (MMSE), diffusion tensor imaging (DTI) followed by estimation of superoxide dismutase, glutathione peroxidase and lipid peroxidation in serum of MCI and control population...
September 7, 2018: International Journal of Neuroscience
Archana Verma, Kiran K, Alok Kumar
AIM OF THE STUDY: This study was aimed to assess belief in medication and non-adherence to antiepileptic drugs (AEDs) in people with epilepsy (PWE) from rural India. And furthermore to study the demographic and seizure attributes influencing the adherence. MATERIALS AND METHODS: Present cross-sectional study included 230 adult PWE. Adherence level was assessed by using validated Morisky-Green test and patient's beliefs towards usage of AEDs by utilizing Beliefs about Medicine Questionnaire (BMQ)...
September 5, 2018: International Journal of Neuroscience
Leila Elyasi, Seyed Hassan Eftekhar-Vaghefi, Majid Asadi-Shekaari, Saeed Esmaeili-Mahani
PURPOSE: Parkinson's disease is a progressive neurodegenerative disease characterized by progressive and selective death of dopaminergic neurons. It has been reported that nicotine and morphine have protective roles during neuronal damage in Parkinson's disease. In addition, the induction of cross-tolerance between their biological effects has been shown in numerous reports. METHODS: Here, we investigated the effects of nicotine and morphine on 6-OHDA-induced neurotoxicity in human neuroblastoma SH-SY5Y cell line as an in vitro model of Parkinson's disease...
September 5, 2018: International Journal of Neuroscience
Leandro Viçosa Bonetti, Syed A Hassan, Sin-Tung Lau, Luana T Melo, Takako Tanaka, Kara Patterson, W Darlene Reid
The prefrontal cortex (PFC) is involved in higher order cognitive functions. Its activity can be assessed by measuring changes in the concentrations of oxyhemoglobin (O2 Hb) and deoxyhemoglobin (HHb) using functional near infrared spectroscopy (fNIRS). The aim of this study was to synthesize PFC fNIRS outcomes on the effects of cognitive tasks compared to resting/baseline tasks in healthy adults from studies utilizing a pre/post design. Original research studies were searched from seven databases (MEDLINE, EMBASE, CENTRAL, CINAHL, SCOPUS, PEDro and PubMed)...
September 1, 2018: International Journal of Neuroscience
José L Ruiz-Sandoval, Erwin Chiquete, Gustavo Parra-Romero, Karina Carrillo-Loza, Juan D Parada-Garza, Héctor R Pérez-Gómez, Miguel R Ochoa-Plascencia, Leonardo Aguirre-Portillo
BACKGROUND: Hypertension is the main cause of intracerebral hemorrhage with a thalamic location frequency that varies from 6 to 26.5%. OBJECTIVE: We aimed to identify clinical and radiological features that could impact the short-term prognosis in patients with hypertensive thalamic hemorrhage (HTH). METHODS: Consecutive patients presenting to a tertiary referral hospital with HTH were analyzed from 2010 to 2014. Clinical features at emergency department and a thirty-day outcome using the modified Rankin Scale (mRS) were obtained...
August 31, 2018: International Journal of Neuroscience
Daisuke Ishii, Daisuke Matsuzawa, Shingo Matsuda, Haruna Tomizawa-Shinohara, Chihiro Sutoh, Eiji Shimizu
Adolescence is a vulnerable period for developing anxiety-related mental disorders such as post-traumatic stress disorder (PTSD), which requires a long-term course of therapy when a traumatic event has been experienced during childhood. However, the biological mechanism underlying these age-dependent characteristics remains unclear. In the present study, we used early adolescent, late adolescent and adult (4-, 8-, and 15-week old) male mice to examine age differences in fear memory, fear extinction, and spontaneous recovery of fear...
August 31, 2018: International Journal of Neuroscience
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