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International Journal of Neuroscience

Daisuke Ishii, Daisuke Matsuzawa, Shingo Matsuda, Haruna Tomizawa-Shinohara, Chihiro Sutoh, Eiji Shimizu
Adolescence is a vulnerable period for developing anxiety-related mental disorders such as post-traumatic stress disorder (PTSD), which requires a long-term course of therapy when a traumatic event has been experienced during childhood. However, the biological mechanism underlying these age-dependent characteristics remains unclear. In the present study, we used early adolescent, late adolescent and adult (4-, 8-, and 15- week-old) male mice to examine age differences in fear memory, fear extinction, and spontaneous recovery of fear...
July 16, 2018: International Journal of Neuroscience
Archana Verma, Kiran K, Alok Kumar
AIM: This study was aimed to assess belief in medication and non adherence to antiepileptic drugs (AEDs) in people with epilepsy (PWE) from rural India. And furthermore to study the demographic and seizure attributes influencing the adherence. METHOD: Present cross-sectional study included two hundred and thirty adult PWE. Adherence level was assessed by using validated Morisky-Green Test and patient's beliefs towards usage of AEDs by utilizing Beliefs about Medicine Questionnaire (BMQ)...
July 16, 2018: International Journal of Neuroscience
Hai-Jiao Wang, Ge Tan, Li-Na Zhu, Deng Chen, Da Xu, Shan-Shan Chu, Liu Ling
Objective To evaluate the efficacy of repetitive transcranial magnetic stimulation for Parkinson disease (PD) patients with depression. Methods A meta-analysis was performed using relevant randomized controlled trials (RCTs) from online databases such as PubMed, Embase, Cochrane Online Library, and Studies were selected according to pre-defined inclusion and exclusion criteria, and the quality of the studies was evaluated using the Jadad Scale. All data were pooled by RevMan 5.2 software for meta-analysis...
July 9, 2018: International Journal of Neuroscience
Sanjeet S Grewal, Andrea C Adams, Jamie J Van Gompel
INTRODUCTION: Hiccups are common and typically resolve spontaneously. However, in rare cases, they can continue for days, weeks or even years, causing significant morbidity and discomfort in patients. In the setting of intractable hiccups, vagal nerve stimulation has been reported in two cases. OBJECTIVES: This is a case report and review of the literature regarding the use of vagal nerve stimulators for intractable hiccups. Specifically, this report highlights a case where this therapy was not effective, as two prior case reports have reported positive results...
July 3, 2018: International Journal of Neuroscience
Tuğba Korkmaz, Aysin Kisabay, Zeliha Hekimsoy, Emel Senol, Deniz Selçuki
PURPOSE: There are many studies on degeneration of the ganglion cells using visual evoked potential (VEP) in Diabetes mellitus (DM). The present study intended to investigate whether the retinopathy findings would be helpful for detecting the degeneration to develop or not in retinal ganglion cells with the VEP test before being detectable in ophthalmoscopic examination on prediabetic patients. MATERIALS AND METHODS: The present study was conducted prospectively after obtaining approval from the Ethics Committee...
July 2, 2018: International Journal of Neuroscience
Qin Sun, Ling-Ling Wei, Min Zhang, Ting-Xin Li, Chun Yang, Shao-Ping Deng, Qing-Cui Zeng
BACKGROUND: Type 2 diabetes mellitus (T2DM) is strongly correlated with Alzheimer's disease (AD). Rapamycin has important uses in oncology, cardiology, and transplantation medicine. This study aims to investigate effects of rapamycin on AD in hippocampus of T2DM rat by AMPK/mTOR signaling pathway. METHODS: Morris water maze test was applied to evaluate the learning and memory abilities. The fasting plasma glucose (FBG), glycosylated hemoglobin, total cholesterol, triglyceride and serum insulin level were measured...
July 2, 2018: International Journal of Neuroscience
Yuan Cheng, Yu-Tao Liu, Zhi-Hua Yang, Jing Yang, Chang-He Shi, Yu-Ming Xu
Pantothenate-kinase-associated neurodegeneration (PKAN), which is characterized by iron accumulation in the basal ganglia, is a rare autosomal recessive neurodegenerative disorder caused by pantothenate kinase (PANK2) gene mutations. The PANK2 gene is located on chromosome 20p13 and encodes pantothenate kinase. Herein, we identified one patient with PKAN who had mutations in the PANK2 gene. We performed clinical and radiographic investigations, and diagnosed this disease at the clinical and genetic levels. It is worth mentioning that the patient displayed an eye-of-the-tiger sign...
July 2, 2018: International Journal of Neuroscience
Rafey A Feroze, Nitin Agarwal, Raymond F Sekula
OBJECTIVE: We have previously documented the utility of calcium phosphate cement cranioplasty following retromastoid craniectomy. In this study, we aimed to demonstrate its efficacy following a supraorbital approach for tumor resection. METHODS: A retrospective analysis of a prospectively maintained database was conducted of 8 bpatients (7 female, 1 male) with anterior cranial fossa meningiomas resected via a supraorbital approach followed by cranioplasty involving adjunctive or sole use of calcium phosphate cement...
June 28, 2018: International Journal of Neuroscience
Leila Elyasi, Seyed Hassan Eftekhar-Vaghefi, Majid Asadi-Shekaaria, Saeed Esmaeili-Mahani
PURPOSE: Parkinson's disease is a progressive neurodegenerative disease characterized by progressive and selective death of dopaminergic neurons. It has been reported that nicotine and morphine have protective roles during neuronal damage in Parkinson's disease. In addition, the induction of cross-tolerance between their biological effects has been shown in numerous reports. METHODS: Here, we investigated the effects of nicotine and morphine on 6-OHDA-induced neurotoxicity in human neuroblastoma SH-SY5Y cell line as an in vitro model of Parkinson's disease...
June 27, 2018: International Journal of Neuroscience
Yuan Fan, Yan Chen, Se Zhang, Mengbing Huang, Shengdong Wang, Ye Li, Jie Bai
Parkinson's disease (PD) is a neurodegenerative disorder. It is caused by the degeneration of dopaminergic neurons and the dopamine (DA) deletion in the substantia nigra pars compacta (SNpc). Morphine elevates the level of dopamine in the mesolimbic dopamine system and plays a role in alleviating PD symptoms. However, the molecular mechanism is still unclear. In present study, we found that morphine increased the cell viability in PC12 cells. 1-methyl-4-phenylpyridinium (MPP+ ) reduced the cell viability and tyrosine hydroxylase (TH) expression, which were reversed by morphine...
June 25, 2018: International Journal of Neuroscience
Chae Young Lee, Jung Han Yoon, Jeong-Ho Park, JinYong Hong, Mun Kyung Sunwoo, Suk Yun Kang
BACKGROUND: Essential tremor (ET) is very common, but characterization is difficult because of its heterogeneity. Neuropathology is important to elucidate the characteristics of neurological disorders. However, pathological findings in ET have been inconsistent among studies. Uric acid (UA) is a strong antioxidant and might be a biomarker in neurodegenerative process. We hypothesized that UA level would be reduced if ET is a neurodegenerative disease. Our aim was to compare UA level between ET patients and healthy individuals...
June 25, 2018: International Journal of Neuroscience
Kaline Rocha, Victor Marinho, Francisco Magalhães, Jéssica Ribeiro, Thomaz Oliveira, Daya S Gupta, Fernanda Chaves, Bruna Velasques, Pedro Ribeiro, Mauricio Cagy, Gildário Lima, Silmar Teixeira
Previous studies have shown that several cortical regions are involved in temporal tasks in multiple time-scales. But the hemispheric predominance of the dorsolateral prefrontal cortex (DLPFC) during time reproduction after repetitive low-frequency transcranial magnetic stimulation (rTMS) is relatively unexplored. Here, we study the effects of 1Hz rTMS and sham stimulation applied medially over the SPC (superior parietal cortex) on the DLPFC alpha and beta band asymmetry and on time reproduction. For this purpose, we have combined rTMS with electroencephalography in 20 healthy subjects who performed the time reproduction task in two conditions (sham and 1Hz)...
June 18, 2018: International Journal of Neuroscience
Emilia Gatto, Virginia Parisi, Gabriel Persi, Estela Fernandez Rey, Martin Cesarini, José Luis Etcheverry, Pablo Rivera, Ferdinando Squitieri
BACKGROUND: Huntington's disease (HD) is a genetic, rare and progressive neurodegenerative disorder that causes motor and cognitive impairment in midlife patients. Although retinal damage was observed in animal HD models and in patients with other neurodegenerative diseases, we still need confirmation of impairment in HD patients. Optical Coherence Tomography (OCT) is a non-invasive methodology that analyzes the retinal nerve fiber layers (RNFL) and could reflect processes of neurodegeneration...
June 18, 2018: International Journal of Neuroscience
Somayeh Sadat Hashemi Kamangar, Zahra Moradimanesh, Setareh Mokhtari, Fatemeh Bakouie
A developmental process can be described as changes through time within a complex dynamic system. The self-organized changes and emergent behaviour during development can be described and modeled as a dynamical system. We propose a dynamical system approach to answer the main question in human cognitive development i.e. the changes during development happens continuously or in discontinuous stages. Within this approach there is a concept; the size of time scales, which can be used to address the aforementioned question...
June 11, 2018: International Journal of Neuroscience
Sara Ganaha, Sanjeet S Grewal, William P Cheshire, Ronald Reimer, Alfredo Quiñones-Hinojosa, Robert E Wharen
Glossopharyngeal neuralgia (GPN) is a condition characterized by sudden, severe pain in the distribution of the glossopharyngeal nerve. It can be triggered by talking, yawning, coughing, and swallowing. Classically, patients experience a unilateral lancinating and excruciating pain described as electrical shock-like pain in the areas around the ear, tongue, or the mandibular angle. Uncommon manifestations include cardiac arrhythmias and syncope during pain episodes. Surgery is indicated in refractory cases...
June 11, 2018: International Journal of Neuroscience
Xiang Yang, Ruofei Liang, Yuekang Zhang
A 29-year-old male exhibited progressive extrusion of the distal end of ventriculoperitoneal(VP) shunt through his urethral orifice within 10 days. The distal end of VP shunt was pulled out from the urethral orifice without bladder repairment, a new VP shunt assisted with ventriculoscope and laparoscope was performed and the distal end of VP shunt was fixd to the suprahepatic space. We firstly report a chronic complication of VP shunt with bladder perforation and extrusion through the urethral orifice in an adult male patient...
June 11, 2018: International Journal of Neuroscience
Elionor Nehme, Sahar Obeid, Souheil Hallit, Chadia Haddad, Wael Salame, Fouad Tahan
OBJECTIVES: To evaluate the effect of psychosis on prognosis as measured by the course of a manic episode, symptoms severity and time to remission and identify existing differences in positive and negative symptoms between psychotic and non-psychotic patients. STUDY DESIGN: 40 bipolar patients presenting with a diagnosis of acute mania were enrolled (18 psychotic patients and 22 non psychotic patients) in this cross-sectional study. Subjects were required to complete two self-reported questionnaires, the Young Mania Rating Scale (YMRS) for manic symptoms, and Positive and Negative Symptoms Scale (PANSS) for psychotic symptoms...
June 11, 2018: International Journal of Neuroscience
Wei Wang, Maode Wang, Zhijin Li, Tuo Wang, Rong Da
PURPOSE: An accurate intracranial pressure (ICP) measurement is vital for patients with hydrocephalus. ICP is generally measured by lumbar puncture opening pressure, which is invasive and has potential adverse side effects. Intraocular pressure (IOP) was investigated to measure ICP indirectly; however, its accuracy was controversial. We conducted this retrospective study to investigate whether IOP can be used as a surrogate for ICP in hydrocephalus patients. METHODS: We performed a retrospective study enrolled 50 cases, including 32 patients with normal pressure hydrocephalus (NPH) and 18 patients with high pressure hydrocephalus (HPH)...
June 8, 2018: International Journal of Neuroscience
Yun Wang, Fei Fei Xia, Wei Wang, Wenli Hu
OBJECTIVE: Despite the availability of highly effective treatments, there is a significant recurrence rate of benign paroxysmal positional vertigo (BPPV). This study is aimed to quantitatively measure sleep quality in BPPV patients and correlate it with the recurrence of BPPV. METHODS: In this longitudinal cohort study, the clinical records of 67 elderly or middle-aged adult patients who were diagnosed with BPPV at Neurology Clinic, Beijing Chaoyang Hospital affiliated to Capital Medical University between 2013 and 2014...
June 8, 2018: International Journal of Neuroscience
William C Hochberger, Jenna L Axelrod, Casey Sarapas, Stewart A Shankman, S Kristian Hill
Research suggests that increasing delays in stimulus read-out can trigger declines in serial order recall accuracy due to increases in cognitive demand imposed by the delay; however, the exact neural mechanisms associated with this decline are unclear. Changes in neural resource allocation present as the ideal target and can easily be monitored by examining changes in the amplitude of an ERP component known as the P3. Changes in P3 amplitude secondary to exogenous pacing of stimulus read-out via increased target-to-target intervals (TTI) during recall could reflect decreased neural resource allocation due to increased cognitive demand...
June 8, 2018: International Journal of Neuroscience
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