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International Journal of Neuroscience

Guang Fang, Baoyan Shi, Kefeng Wu, Siyu Chen, Xiang Gao, Sa Xiao, Jing X Kang, Wende Li, Ren Huang
OBJECTIVES: The role of n-3 polyunsaturated fatty acid (PUFA) as the main docosahexaenoic acid (DHA) in Alzheimer's disease (AD) remains controversial. Our study aimed to provide detailed information about the role of endogenous n-3 PUFAs in AD. METHODS: Here, we generated a fat-1/tau transgenic mouse AD model by crossing female tau mice with male fat-1 mice to exclude confounding variables associated with the benefit of a DHA diet in these AD mice models. PUFAs presented in these AD models were detected by gas chromatography, and the role of endogenous n-3 PUFAs was assessed by lifespan survival assay, behavioral, pathologic, and molecular biology testing as well as imaging of cerebral vasculature...
November 2, 2018: International Journal of Neuroscience
Lailson Bezerra Lima, Manoel Alves Sobreira-Neto, Pedro Braga-Neto, Paulo Ribeiro Nóbrega
The association between Rosai-Dorfman Disease (RDD) and cancer was reported for the first time in 1984. However, there are still a small number of reports of this association. We describe a 60-year-old woman who presented with a focal onset motor seizure followed by tonic-clonic generalization and persistent headache. Magnetic Resonance Imaging disclosed an irregular hyperintense lesion in T2 and vasogenic edema in the left parietal region. Immunohistochemical analysis of a biopsy fragment was positive for protein S-100 and CD68 and negative for CD1a, compatible with the diagnosis of RDD...
October 31, 2018: International Journal of Neuroscience
Hamdino Attia, Medhat Taha, Ahmed Abdellatif
AIM OF THE STUDY: Cognitive decline due to aging is most probably the result of changes in the white matter in the central nervous system (CNS) and/or demyelination. MATERIAL AND METHODS: We used electron microscopic analysis of the morphological changes in aging rats' optic nerves as an easily accessible part of the CNS. RESULTS: Several age changes were observed in aging rats (36 months) vs. young adult rats (6 months), namely degeneration of axons, decreased packing density and morphological alterations of myelination, including the ballooning of some myelin sheaths, separation of myelin lamellae and degenerative changes in the oligodendrocytes population...
October 31, 2018: International Journal of Neuroscience
Ali Asmail, Anat Kesler, Hadar Kolb, Vivian E Drory, Arnon Karni
BACKGROUND: A tri-modal distribution of age-at-onset emerged among females patients with myasthenia gravis (MG) in our database. This finding may be indicative of different gender-based disease mechanisms. METHODS: We retrospectively reviewed the files of 127 MG patients for the clinical, serology and thymus pathology according to their age at disease onset: ≤40 years (early-onset, EOMG), 40-70 years (intermediate-onset, IOMG) and >70 years (late-onset, LOMG)...
October 31, 2018: International Journal of Neuroscience
Siddika Halicioglu, Sule Aydin Turkoglu
OBJECTIVE: Multiple sclerosis (MS) is a demyelinating autoimmune disease of the central nervous system. T2W-hyperintense demyelinating lesions are detected in cranial magnetic resonance imaging (MRI). Developmental venous anomalies (DVAs) have frequently been detected in enhanced cranial MRI images, and are generally accepted as normal variants of venous development. The aim of the present study was to investigate whether there was an association between demyelinating diseases and venous anomalies...
October 31, 2018: International Journal of Neuroscience
Bina Kumari Mehta, Kaushal Kumar Singh, Sugato Banerjee
OBJECTIVES: Type 2 diabetes (T2D)-associated cognitive impairment is highly prevalent especially among the geriatric population. Here, we investigate the role of exercise in T2D-associated cognitive decline in rats. METHODS: T2D was induced using high-fat diet (15 days) followed by low-dose STZ (25mg/kg). The T2D animals were subjected to aerobic exercise on running wheel for 6 weeks. Effect of aerobic exercise on cognitive performance of T2D animals was measured using step-down and transfer latency tests...
October 31, 2018: International Journal of Neuroscience
Leandro Viçosa Bonetti, Syed A Hassan, Sin-Tung Lau, Luana T Melo, Takako Tanaka, Kara K Patterson, W Darlene Reid
PURPOSE OF THE STUDY: the aim of this study was to synthesize PFC fNIRS outcomes on the effects of cognitive tasks compared to resting/baseline tasks in healthy adults from studies utilizing a pre/post design. MATERIAL AND METHODS: original research studies were searched from seven databases (MEDLINE, EMBASE, CENTRAL, CINAHL, SCOPUS, PEDro and PubMed). Subsequently, two independent reviewers screened the titles and abstracts followed by full-text reviews to assess the studies' eligibility...
October 31, 2018: International Journal of Neuroscience
José L Ruiz-Sandoval, Erwin Chiquete, Gustavo Parra-Romero, Karina Carrillo-Loza, Juan D Parada-Garza, Héctor R Pérez-Gómez, Miguel R Ochoa-Plascencia, Leonardo Aguirre-Portillo
BACKGROUND: Hypertension is the main cause of intracerebral hemorrhage with a thalamic location frequency that varies from 6% to 26.5%. OBJECTIVE: We aimed to identify clinical and radiological features that could impact the short-term prognosis in patients with hypertensive thalamic hemorrhage (HTH). METHODS: Consecutive patients presenting to a tertiary referral hospital with HTH were analyzed from 2010 to 2014. Clinical features at emergency department and a 30-day outcome using the modified Rankin Scale (mRS) were obtained...
October 31, 2018: International Journal of Neuroscience
Ioanna Chalimou, Antonios Krilis, Garifallia G Anastopoulou, Heike Braun, Michael Vikelis, Alexandra Makridou, Nicolaos Makris, Andreas A Argyriou
Purpose/aim: We describe, in detail, the first case of isotretinoin-induced aseptic meningitis. A brief summary of the literature on drug-induced aseptic meningitis (DIAM) is also presented. MATERIALS AND METHODS: A 20-year old female patient with probable (Naranjo adverse reaction probability score of 7) DIAM during treatment with isotretinoin therapy for nodular acne solely, presenting with headache. Pseudotumor cerebri was appropriately ruled-out. RESULTS: Summary of data altogether lead us suggest that isotretinoin triggered DIAM, possible due to a delayed hypersensitivity mechanism type III or IV...
October 31, 2018: International Journal of Neuroscience
Zibao Li, Bo Sun, Mengmeng Gu, Mengmeng Wang, Xi Cheng, Jia Lv, Si Cen, Shuai Zhang, Zhengze Dai, Yongjie Bai, Shun Li, Guiling Wang, Zhiqiang Weng, Yonghui Shi, Zhizhong Zhang, Xinfeng Liu
BACKGROUND: A recent genome-wide association study has identified that rs4376531 variant conferred risk of atherothrombotic stroke (AS) in a Japanese population. This study was to explore the association in Han Chinese population. METHODS: A total of 1036 cases and 643 healthy controls were enrolled. We genotyped rs4376531 variant with SNPscan. Multivariate logistic regression analysis was used to determine the association of genetic variation with risk of AS. Interaction analysis was examined by SNPStats web tool...
October 31, 2018: International Journal of Neuroscience
Qiaowen Tong, Weiwei Xiang, Hua Ye, Hehui Zhang, Yiyi Chen, Weian Chen, Chunfeng Liu
AIM OF THE STUDY: Acute central nervous system viral infections are progressive and inflammatory diseases with inflammatory cells infiltrating into the central nervous system (CNS), and thyroid hormone (TH) level is associated with the oxidative and antioxidant status. Variations in oxidative stress and antioxidant status are related to the pathogenesis of inflammatory diseases. Our study aimed to investigate the possible correlation between viral infections in CNS and TH levels of thyroid stimulating hormone (TSH), free thyroxine (fT4) and free triiodothyronine (fT3)...
October 31, 2018: International Journal of Neuroscience
Hamidreza Jahanbani-Ardakani, Fereshteh Alsahebfosoul, Saeed-Reza Moshfeghi, Behzad Mahaki, Masoud Etemadifar, Seyed-Hossein Abtahi, Mahboobeh Fereidan-Esfahani
No abstract text is available yet for this article.
October 31, 2018: International Journal of Neuroscience
Marina V Shulskaya, Maria I Shadrina, Natalia A Bakilina, Svetlana V Zolotova, Petr A Slominsky
AIM OF THE STUDY: It was found that the mutations in the SDHD gene, encoding one of subunits of the succinate dehydrogenase complex, lead to the development of head and neck paraganglioma (HNPGL). We analyzed this gene in 91 patients with HNPGL from Russia. MATERIALS AND METHODS: DNA was isolated from the whole blood. A screening for mutations was performed by Sanger sequencing. RESULTS: We revealed three missense mutations that have been described previously: p...
October 30, 2018: International Journal of Neuroscience
Longxiao Wei, Kun Guo, Yunbo Li, Zhirui Guo, Chengcheng Gao, Menghui Yuan, Ming Zhang
PURPOSE: To create a standard Western Chinese normal functional brain database for quantitative analysis using 2-deoxy-2-[18F] fluoro-D-glucose (18 F-FDG) positron emission tomography (PET) images and MIMneuro software. METHODS: 78 healthy right-handed Chinese volunteers from Tangdu Hospital were scanned using 18 F-FDG PET to evaluate brain metabolism between March and October 2016. All PET images were processed using MIMneuro software to create a normal database platform...
October 30, 2018: International Journal of Neuroscience
Yunfeng Han, Hongyan Yang, Libo Li, Xiaohui Du, Chao Sun
PURPOSE: Schisanhenol is a compound derived from the fruit of a traditional Chinese herb Schisandra rubriflora. The aim of the present study was to evaluate the effect of Schisanhenol on the cognitive impairment induced by scopolamine. MATERIAL AND METHODS: Male mice were randomly divided into three Schisanhenol groups (10, 30, 100 mg/kg), Galantamine group (3 mg/kg), model group (1mg/kg scopolamine), and vehicle control group (normal saline). The learning and memory ability of mice was monitored by water morris maze...
October 30, 2018: International Journal of Neuroscience
Tuğba Korkmaz, Aysın Kisabay, Zeliha Hekimsoy, Emel Senol, Deniz Selçuki
PURPOSE: There are many studies on degeneration of the ganglion cells using visual evoked potential (VEP) in Diabetes mellitus (DM). The present study intended to investigate whether the retinopathy findings would be helpful for detecting the degeneration to develop or not in retinal ganglion cells with the VEP test before being detectable in ophthalmoscopic examination on prediabetic patients. MATERIALS AND METHODS: The present study was conducted prospectively after obtaining approval from the Ethics Committee...
October 30, 2018: International Journal of Neuroscience
Yuan Fan, Yan Chen, Se Zhang, Mengbing Huang, Shengdong Wang, Ye Li, Jie Bai
AIM OF THE STUDY: Parkinson's disease (PD) is a neurodegenerative disorder. It is caused by the degeneration of dopaminergic neurons and the dopamine (DA) deletion in the substantia nigra pars compacta (SNpc). Morphine elevates the level of dopamine in the mesolimbic dopamine system and plays a role in alleviating PD symptoms. However, the molecular mechanism is still unclear. The aim of the study is to investigate the mechanism on morphine alleviating PD symptoms. MATERIALS AND METHODS: The viability of PC12 cells was measured by using MTT assay...
October 30, 2018: International Journal of Neuroscience
Sara Ganaha, Sanjeet S Grewal, William P Cheshire, Ronald Reimer, Alfredo Quiñones-Hinojosa, Robert E Wharen
Glossopharyngeal neuralgia (GPN) is a condition characterised by sudden, severe pain in the distribution of the glossopharyngeal nerve. It can be triggered by talking, yawning, coughing and swallowing. Classically, patients experience a unilateral lancinating and excruciating pain described as electrical shock-like pain in the areas around the ear, tongue, or the mandibular angle. Uncommon manifestations include cardiac arrhythmias and syncope during pain episodes. Surgery is indicated in refractory cases. Bilateral GPN is rare, and definitive surgical treatment for bilateral GPN has not yet been reported...
October 30, 2018: International Journal of Neuroscience
Di Guo, Yanli Li, Haiyun Wang, Xinyue Wang, Wei Hua, Qingkai Tang, Lumin Miao, Guolin Wang
PURPOSE: Animal studies have demonstrated that propofol post-conditioning produces long-term neuroprotection in focal cerebral ischemia-reperfusion injury. However, whether propofol post-conditioning provides neuroprotection in human beings has never been explored. The aim of this study was to evaluate the role of propofol post-conditioning on oxidative stress and post-operative cognitive function following aneurysm clipping. MATERIALS AND METHODS: Sixty patients undergoing intracranial aneurysm clipping were randomized into a propofol post-conditioning group or a sevoflurane group...
October 30, 2018: International Journal of Neuroscience
Haytham Rizk, Mahmoud Allam, Ahmed Hegazy, Haytham Khalil, Hanan Helmy, Hebatalla Hashem, Foad Abd-Allah
BACKGROUND: This study aims to investigate the relationship between cerebrovascular reserve (CVR) capacity, as measured by single-photon emission computed tomography (SPECT) and collateral blood flow, according to a transcranial colour-coded duplex(TCCD), in patients with symptomatic total carotid occlusion (TCO). Additionally, the study aims to determine whether vascular risk factors have an effect on collateral blood flow, as well as on the CVR. METHODS: Thirty-four patients with chronic TCO, diagnosed by carotid duplex scanning and confirmed by other vascular imaging modalities, who had ischaemic symptoms either as stroke or transient ischaemic attack (TIA), were subjected to clinical assessment, SPECT under dipyridamole stress, and grading of cerebral collateral blood flow using TCCD...
October 29, 2018: International Journal of Neuroscience
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