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International Journal of Neuroscience

Metin Celiker, Ayhan Kanat, Mehmet Dumlu Aydin, Dogukan Ozdemir, Nazan Aydin, Coskun Yolas, Muhammed Calik, Halil Olgun Peker
OBJECTIVE: The exact mechanism of phonophobia induced by subarachnoid hemorrhage (SAH) has not been understood well. This subject was investigated. MATERIAL AND METHODS: This study was conducted on 25 rabbits. They divided into three groups; Five as control, five as SHAM, twenty as SAH group. All animals objected to 85 dB impulse noise by daily periods and their phonophobic score values were examined by daily periods for twenty days. Their brains, trigeminal ganglia were extracted bilaterally...
January 14, 2019: International Journal of Neuroscience
Calan Savoy, Karen J Mathewson, Louis A Schmidt, Katherine M Morrison, Saroj Saigal, Michael H Boyle, Ryan J Van Lieshout
Purpose/Aim: Antenatal corticosteroid therapy (ACS) has dramatically increased survival rates among extremely low birthweight (ELBW) infants. However, the long term effects of ACS on autonomic nervous system function have not been explored. Using the world's oldest longitudinally followed cohort of ELBW infants we compared respiratory sinus arrhythmia (RSA) among ELBW survivors whose mothers received ACS (ELBW-S), those who did not (ELBW-NS), and normal birth weight (NBW) controls in their 20s and 30s. METHODS: Resting electrogardiogram (ECG) was recorded from ELBW-S (n=28), ELBW-NS (n=36), and matched NBW controls (n=79) at 22-26 years and 29-36 years...
January 11, 2019: International Journal of Neuroscience
Xue Yang, An-Ning Li, Xiu-He Zhao, Xue-Wu Liu, Sheng-Jun Wang
BACKGROUND: Antibodies against leucine-rich glioma inactivated 1 (LGI1) are associated with limbic encephalitis and faciobrachial dystonic seizures (FBDS). We present a large series of Han Chinese patients for further clinical refinement. METHODS: Serum and cerebrospinal fluid samples from patients were tested. Clinical information of patients with serum anti‑LGI1antibody positivity was retrospectively reviewed, and descriptive statistical analysis was performed...
January 9, 2019: International Journal of Neuroscience
Tao Jun, Li Liu, Yang Fan, Mengke Wang, Lin Li, Lifang Zou, Huilong Yuan, Liran Shi, Runan Yang, Shangdong Liang, Shuangmei Liu
AIM OF THE STUDY: The present study investigated whether the neuronal P2X3 receptor in rat dorsal root ganglia (DRG) mediated the effects of hesperidin on neuropathic pain. MATERIALS AND METHODS: The chronic constriction injury (CCI) model was used as a model of neuropathic pain. The mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) were measured. The mRNA and protein expression levels were assayed by real-time RT-PCR and Western blotting...
January 9, 2019: International Journal of Neuroscience
Ronny Grunert, Andre Krause, Silvio Feig, Juergen Meixensberger, Christian Rotsch, Welf-Guntram Drossel, Peter Themann, Dirk Winkler
Background At present, there are no meaningful and sophisticated computer games that simultaneously allow the treatment of movement disorders such as Parkinson's syndrome. In particular, there are no systems to consider the severity of the disease and the physical skills of the patient. Methods A computer game using the Microsoft Kinect as markerless sensor for the 3D recognition of the patient's movement was developed to support the rehabilitation. The scenario of a basketball game was created after determining that the movement like throwing a ball and the correct posture of the body are important...
January 9, 2019: International Journal of Neuroscience
Mariya M Mikhailova, Alexey P Bolshakov, Chaban A Ekaterina, Mikhail A Paltsev, Andrey A Panteleyev
Primary culture is an effective experimental model to study molecular mechanisms that drive axonal regeneration after central nervous system injury. Nevertheless, the culture of spinal cord (SC) cells remains poorly characterized. Here, we have analysed the cell composition of a primary SC culture during its maturation. It was found that β3-tubulin (general neuronal marker) and nestin (a marker of neuronal stem cells) were both expressed at day 2 of culture in vitro. Surprisingly (given the use of differentiation-supporting culture medium), the number of nestin+ cells has significantly increased during the first week of cultivation...
January 9, 2019: International Journal of Neuroscience
Simona Santoro, Viviana Lo Buono, Francesco Corallo, Emanuele Cartella, Katia Micchia, Rosanna Palmeri, Francesca Arcadi, Alessia Bramanti, Silvia Marino
Motor imagery (MI) is the mental representation of a movement without engaging its actual execution. MI shares neuroanatomical correlates with brain motor networks. Neurologic disorders affecting motor skills, such as stroke, have been related to impairments in MI. A descriptive review was conducted to explore the effects of stroke on MI ability and its background mechanisms. We searched on PubMed and Web of Science databases and screening references of included studies and review articles for additional citations...
January 9, 2019: International Journal of Neuroscience
Abdul Qayyum Rana, Abdul Rehman M Qureshi, Syed Fayyaz H Rizvi, Mohammed M Mohiuddin, Bilal Hussain Syed, Zainab Sarfraz, Ruqqiyah Rana
OBJECTIVES: Although there have been numerous studies conducted to better understand Parkinson's disease (PD), the epidemiology of its debilitating non-motor symptoms across different ethnicities remains understudied. Herein we explore the relationship between depression, anxiety and pain in PD patients of Caucasian or Indian ethnicity (PD Caucasians and PD Indians). PATIENTS AND METHODS: All patients and healthy age and gender matched controls were assessed via semi-structured interviews for anxiety, pain, and depression using structured questionnaires...
January 7, 2019: International Journal of Neuroscience
Ju Qiu, Huai-Dong Cheng, Ting Dong, Li Xiang, Min Wang, Lan Xia, Kai Wang
OBJECTIVE: A vast majority of the episodic memory literature in white matter lesions (WML) had focused on "retrospective memory (RM)", little was known about prospective memory (PM) in WML patients. The aim of our study was to investigate the effect of WML patients on event-based prospective memory (EBPM) and time-based prospective memory (TBPM). In addition, our study attempted to understand the possible mechanisms of PM damage in WML patients. METHODS: A total of 42 WML patients and 40 age and education level matched healthy controls were included...
January 7, 2019: International Journal of Neuroscience
Hongzhi Zhou, Xin Wang, Liming Ma, Aiqing Deng, Shouyan Wang, Xia Chen
AIM: Autophagy was activated after cerebral ischemia reperfusion (I/R) injury. However, the molecular mechanisms underlying regulation of autophagy in cerebral I/R injury were not completely understood. Studies reported that Forked-box class O (FoxO) transcription factors involved in autophagy and might be the regulator of autophagy in multiple cells. In this study, we investigated the effects of FoxO3 on regulating autophagy after cerebral I/R injury. MATERIALS AND METHODS: Rats were subjected to MCAO for 2 h and reperfusion for different times, western blot was used to examine the expression of p-FoxO3, FoxO3 and the autophagic marker LC3 and Beclin-1 in penumbral region...
December 31, 2018: International Journal of Neuroscience
Mona Hussein, Wael Fathy, Tamer Nabil, Rehab Abd Elkareemd
INTRODUCTION: There is alarming evidence about the involvement of general anaesthesia in the development of postoperative cognitive dysfunction. AIM: To clarify the impact of general anaesthesia on cognitive function and to study the possible effect of general anaesthesia on serum S100B, the marker of neuronal degeneration. METHODS: This is a prospective randomized controlled study carried out on 50 patients undergoing elective laparoscopic cholecystectomy under conventional general anaesthesia...
December 27, 2018: International Journal of Neuroscience
Chenchen Liu, Jie Cao, Zhuyi Su, Shabei Xu
Posterior reversible encephalopathy syndrome (PRES) is a clinical-radiological syndrome, reversible vasogenic edema predominantly within parieto-occipital regions. However, isolated brainstem involvement in PRES has been rarely reported, little is known about its clinical manifestations, radiological features and outcomes. We reported a case with PRES with only brainstem involvement and performed a systematic review of published cases. Twenty-four cases, together with our case, were included in the analysis...
December 27, 2018: International Journal of Neuroscience
Yagiz Yolcu, Mohammed Alvi, Nathan Wanderman, Bayard Carlson, Arjun Sebastian, Mohamad Bydon, Brett Freedman
Teriparatide (Human recombinant Parathyroid Hormone 1-34) is an anabolic agent that is frequently used in patients with osteoporosis and has been extensively investigated with animal model and clinical studies in current literature. The findings from preclinical studies that have investigated the role of teriparatide in animal models are summarized in presented review. Overall, the studies show an improvement in bone mineral density and increased fusion rates for osteoporotic animals undergoing spine fusion with teriparatide use...
December 27, 2018: International Journal of Neuroscience
Wei Wu, Yanyin Han, Xiaoli Fan, Li Qinghu, Li Sun
The main pathological change of Parkinson's disease (PD) is progressive degeneration and necrosis of dopaminergic neurons in the midbrain, forming a Lewy body in many of the remaining neurons. Studies have found that in transgenic Drosophila, mutations in the PTEN-inducible kinase 1 (PINK1) gene may cause indirect flight muscle defects in Drosophila, and mitochondrial structural dysfunction as well. In this study, Wnt4 gene overexpression and knockdown were performed in PINK1 mutant PD transgenic Drosophila, and the protective effect of Wnt4 gene on PD transgenic Drosophila and its possible mechanism were explored...
December 11, 2018: International Journal of Neuroscience
Vikas K Singh, Shipra Singh, Leela Bhupalam
Oligodendrogliomas are a rare type of primary brain tumor. They are genetically defined as diffuse gliomas carrying mutation in isocitrate dehydrogenase type 1 (IDH1) or type 2 (IDH2) and codeletion of chromosomes 1p and 19q. The WHO grading system distinguishes two histopathologic grades of ODs: grade II (low-grade) and grade III (anaplastic oligodendroglioma or AO). These tumors rarely metastasize outside of central nervous system with only few cases reported in the literature. Here we present a case of an AO, which metastasized to the bone marrow and other sites within a year of diagnosis despite aggressive treatment measures...
December 11, 2018: International Journal of Neuroscience
Melissa Mercadante Santana Cruz, Christiane de Mesquita Barros Almeida Leite, Maria Eliana Madallozzo Schieferdecker, Hélio Afonso Ghizoni Teive, Bruno Dezen Vieira, Adriana Moro
BACKGROUND: neurodegenerative diseases may progress to a level in which patients present spontaneous weight loss, resulting in increased falls and functional disabilities when the disease is associated with muscle mass depletion. OBJECTIVE: evaluate the muscle compartment in patients presenting spinocerebellar ataxia (SCA) type 3 and 10. METHODS: forty-six patients presenting SCA type 3 and 10 were assessed and 76 volunteers were selected to the control group...
December 7, 2018: International Journal of Neuroscience
Mehmet Taşkıran, Abdulkadir Taşdemir, Nusret Ayyıldız, Mustafa Ayyildiz, Erdal Agar
This study was aimed at examining the epileptiform activity of the 5-HT2 serotonin receptor agonist and antagonist, and 5-hydroxytryptophan (5-HTP) in penicillin-induced epilepsy in albino Wistar rats. For this purpose, 90 albino male Wistar rats were used in this study. Epileptiform activity was induced by an injection of penicillin, an agonist of GABAA receptor, (500 IU, ic) into the somatomotor cortex. Thirty minutes after the injection of penicillin, 2,5-dimethoxy-4-iodoamphetamine (DOI, an agonist of 5-HT2 receptor) (0...
December 7, 2018: International Journal of Neuroscience
Zahra Khalesi, Michelle K Jetha, Kristie L Poole, Joel O Goldberg, Ryan J Van Lieshout, Louis A Schmidt
OBJECTIVE: Although individual differences in personality are known to influence quality of life in individuals with schizophrenia, relatively few studies have attempted to identify putative links underlying this relation. METHODS: Here, we examined associations among temperamental shyness, hormones (ie baseline salivary cortisol and testosterone), and quality of life (QoL) measured in 42 stable outpatient adults with schizophrenia. RESULTS: We found that baseline cortisol, but not testosterone, moderated the relation between shyness and QoL (ß = 1...
December 5, 2018: International Journal of Neuroscience
Marta Maschio, Giada Pauletto, Alessia Zarabla, Andrea Maialetti, Tamara Ius, Veronica Villani, Alessandra Fabi, Tatiana Koudriavtseva, Diana Giannarelli
INTRODUCTION: Epilepsy occurs in 35-70% of patients with gliomas; glutamate plays a central role via AMPA-receptor activation, which is involved both in seizure activity and tumor growth. We conducted a retrospective study on brain tumour-related epilepsy patients (BTRE) treated with perampanel in add-on (PER) for 12 months, to evaluate efficacy and tollerability, according to real-life clinical practice. MATERIALS AND METHODS: Medical records of eleven patients (9 males, mean age 54 years) with glioma and epilepsy treated with PER in add-on, for inadequate seizure control or adverse events (AEs) from previous antiepileptic drugs (AEDs) therapy, were reviewed...
December 3, 2018: International Journal of Neuroscience
Hong-Hua Kang, Yong-Qiang Shu, Lin Yang, Pei-Wen Zhu, Dan Li, Qing-Hai Li, You-Lan Min, Lei Ye, Qiong Zhou, Yi Shao
OBJECTIVE: The targets of this study was to access the alternations of spontaneous brain activity in RD patients by amplitude of low-frequency fluctuation (ALFF) method and to explore their relationships with clinical behavioral performance. METHODS: 20 patients with RD (6 males and 14 females), and 20 healthy controls (HCs) (6 males and 14 females) were recruited, and were matched in sex and age. All participants finished the functional magnetic resonance imaging (fMRI) scanning...
November 30, 2018: International Journal of Neuroscience
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