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International Journal of Neuroscience

Shuai Miao, Shaohua Liao, Heng Li, Bing Niu, Huaiqiang Hu, Ying Qian, Hongwei Guo, Bingzhen Cao
OBJECTIVE: To analyze the clinical features, diagnostic strategies and therapeutic methods associated with paraneoplastic neurological syndromes (PNS). METHODS: A retrospective study of PNS was performed at a single center in Shandong, East China. The medical records and follow-up data of 28 PNS patients were intensively reviewed between February 2011 and December 2014. RESULTS: A total of 28 patients diagnosed with PNS were included in this study...
January 22, 2018: International Journal of Neuroscience
Arash Salmaninejad, Saeed Farajzadeh Valilou, Hadi Bayat, Nader Ebadi, Abdolreza Daraei, Meysam Yousefi, Abolfazl Nesaei, Majid Mojarrad
Duchenne muscular dystrophy (DMD) is a lethal progressive pediatric muscle disorder and genetically inherited as an X-linked disease that caused by mutations in the dystrophin gene. DMD leads to progressive muscle weakness, degeneration, and wasting; finally, follows with the premature demise in affected individual's due to respiratory and/or cardiac failure typically by age of 30. For decades, scientists tried massively to find an effective therapy method, but there is no absolute cure currently for patients with DMD, nevertheless, recent advanced progressions on the treatment of DMD will be hopeful in the future...
January 19, 2018: International Journal of Neuroscience
Mark F Lew, Allison Brashear, Khashayar Dashtipour, Stuart Isaacson, Robert A Hauser, Pascal Maisonobe, Daniel Snyder, William Ondo
Purpose/aim: AbobotulinumtoxinA (Dysport®, Ipsen Biopharmaceuticals, Inc., Basking Ridge, NJ, USA) is an acetylcholine release inhibitor and a neuromuscular blocking agent. The United States prescribing information for abobotulinumtoxinA previously indicated only one dilution for cervical dystonia: 500 U/1 mL. Clinical trial data supporting a larger volume with a 500 U/2 mL dilution would offer clinicians flexibility with injection volume to better meet patient needs. MATERIALS AND METHODS: We conducted a 12-week, phase 3b, multicenter, randomized, double-blind, placebo-controlled trial (NCT01753310)...
January 17, 2018: International Journal of Neuroscience
Qi Liu, Hang Zhang, Jian Xu, Dong Zhao
Objectives Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Neuritin is a neurotrophic factor that regulates neural growth and development. However, the role of neuritin in alleviating TBI has not been investigated. Methods In this study, Sprague Dawley rats (n = 144) weighing 300 ± 50 g were categorized into control, sham, TBI, and TBI + neuritin groups. The neurological scores and the ultrastructure of cortical neurons, apoptotic cells, and caspase-3 were measured by using Garcia scoring system, transmission electron microscopy, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling, Western blot analysis, and real-time RT-PCR at various time points post-TBI...
January 15, 2018: International Journal of Neuroscience
Yuichi Kondo, Kazunari Fushimi, Makoto Takasawa, Shigeo Kanamori, Takaki Miyagawa, Kenji Kawashima, Kazutoshi Yokoyama, Haruhiko Akiyama
Intracranial hemorrhage is a rare complication of spinal surgery. Case 1 was a 58-year-old man who underwent cervical laminoplasty. No apparent iatrogenic dural rupture or cerebrospinal fluid leakage was observed. An hour after the surgery, the patient had convulsions and became restless thereafter. CT revealed an intracranial SAH. The patient recovered normal consciousness the next morning. Case 2 was a 68-year-old woman who underwent cervical laminoplasty without postoperative CSF leakage. Six days after the surgery, the patient continued to complain of nausea and headache...
January 12, 2018: International Journal of Neuroscience
Ahad Ashrafi-Asgarabad, Saeid Safiri
No abstract text is available yet for this article.
January 10, 2018: International Journal of Neuroscience
Tao Li, Yu-Tang Li, Di-Yu Song
In this study, we used Anakinra to inhibit the expression of IL-1β based on the model of spinal cord injury in the rat stomach, and explored whether it had a certain neuroprotective effect after spinal cord injury. The spinal cord injury model of 4 segments (T5-T8) was prepared by using vascular clamp. 30 rats were randomized to the control group and the experimental group, and the control group used normal saline while the experimental group used Anakinra after spinal cord injury. The spinal cord tissue was extracted at the 6 h and 24 h after the operation to carry out the histopathological evaluation and to analyze the contents of IL-1β and malondialdehyde and the activities of glutathione peroxidase and superoxide dismutase...
January 8, 2018: International Journal of Neuroscience
Li-Min Li, Hui-Yue Guo, Ning Zhao, Lin-Jie Zhang, Ningnannan Zhang, Jingchun Liu, Li Yang
OBJECTIVES: Olfactory dysfunction (ODF) has been reported in patients with neuromyelitis optica (NMO) and multiple sclerosis (MS). However, the comparison of olfactory function and olfactory-related gray matter (GM) between patients with NMO and MS needed to be further elucidated. MATERIALS AND METHODS: Thirty-seven patients with NMO and 37 with MS were enrolled. Olfactory function was evaluated with a Japanese T&T olfactometer test kit, and the neuroanatomical features of olfactory-related GM were assessed using voxel-based morphometry...
January 3, 2018: International Journal of Neuroscience
Robert Rutkowski, Robert Chrzanowski, Magdalena Trwoga, Jan Kochanowicz, Grzegorz Turek, Zenon Mariak, Joanna Reszeć
OBJECTIVE: To analyze the expression of β-catenin and N-cadherin in large series of meningioma cases and to investigate their correlation with peritumoral brain edema (PTBE). MATERIALS AND METHODS: Study group consists of 154 patients diagnosed with intracranial meningioma divided into: low-grade (G1) and high-grade (G2 or G3) group. PTBE was graded into 4 groups (0,I,II,III) using Steinhoff classification. The expression of N-cadherin, β-catenin was analyzed and graded based on the positive ratio of immunoreactivity...
January 3, 2018: International Journal of Neuroscience
Guohua Zhao, Xiaomin Liu, Qiong Zhang, Kang Wang
PURPOSE OF THE STUDY: Though rare, children are susceptible to paroxysmal dyskinesias (PxDs) such as paroxysmal kinesigenic dyskinesia (PKD), and infantile convulsions and choreoathetosis (ICCA, also termed PKD/IC). PKD is characterized by recurrent attacks of involuntary movements mostly starting around puberty, and PKD/IC also presents with clusters of non-febrile seizures at ages between 3 and 12 months in addition to symptoms of PKD. Recent studies showed that the cause of PKD or PKD/IC could be proline-rich transmembrane protein 2 (PRRT2) gene mutations...
December 29, 2017: International Journal of Neuroscience
Yifan Zhang, Dongmei Guo, Yi Tang
X-linked adrenoleukodystrophy is an inherited disease caused by abnormal accumulation of very long chain fatty acids. The diagnosis of X-linked adrenoleukodystrophy can be confirmed with the mutation of ABCD1 gene. The main symptom of the X-linked adrenoleukodystrophy is spastic paraparesis, and autonomic dysfunction is rare in X-linked adrenoleukodystrophy. Here, we presented an X-ALD case of a 46-year-old Asian male with severe autonomic dysfunction. Impairment of the autonomic nervous system may closely relate to mitochondrial defect...
December 28, 2017: International Journal of Neuroscience
Xiaoling Gao, Shujie Wu, Yanting Dong, Yaqiong Huang, Yan Chen, Yan Qiao, Zhanjun Dou, Bei Wang
This study investigated the effect of rimonabant, a cannabinoid receptor type 1 (CB1) antagonist, on calcium/calmodulin dependent protein kinase II (CaMKII) and CB1 in chronic intermittent hypoxia (CIH). Healthy male rats were divided into the following treatment groups (n = 10/group): control group (CG), intermittent hypoxia group (IH) for 4 or 6 weeks, hypoxic intervention group (HI) that received rimonabant (1 mg/kg/d) prior to exposure to hypoxia and for 4 or 6 weeks. Morphological changes and CaMKII and CB1 expression in cerebral hippocampus cells were determined by hematoxylin-eosin staining (HE) and immunohistochemistry, respectively...
December 21, 2017: International Journal of Neuroscience
Foad Abd-Allah, Eman Khedr, Mohammed I Oraby, Ahmed Safwat Bedair, Shady Samy Georgy, Ramez Reda Moustafa
OBJECTIVES: Accurate data on the epidemiology of stroke in Egypt is scarce. The aim of this review is to address this issue based on available community-based studies and compare the resulting findings to those of other regional and international studies. METHOD: A systematic literature search was conducted to identify population-based epidemiological studies of stroke in Egyptians. Original articles published in English between 1990 and 2016 were included. Five studies from 5 different governorates in southern Egypt fulfilled the study criteria (Qena, Sohag, Assiut, New Valley and Red Sea)...
December 19, 2017: International Journal of Neuroscience
Xin Zhou, Chunrong Wang, Zhao Chen, Yun Peng, Huirong Peng, Xuan Hou, Wei Ye, Rong Qiu, Kun Xia, Beisha Tang, Hong Jiang
BACKGROUND: Recent evidence suggested that several single nucleotide polymorphisms (SNPs) of inflammation-related genes (TNF-α rs1799964, IL-1α rs1800587, IL-1β rs16944, IL-8 rs4073, ICAM-1 rs5498) were associated with multiple system atrophy (MSA). Herein, we conducted this case-control study to evaluate the possible correlation between the five SNPs related to inflammatory and MSA in Chinese Han population. METHODS AND PATIENTS: We recruited 154 sporadic patients with MSA and 223 health controls in this study...
December 18, 2017: International Journal of Neuroscience
Yuanyuan Huang, Zhaojian Ying, Weiwei Quan, Weiwei Xiang, Dewei Xie, Yiyun Weng, Xiang Li, Jia Li, Xu Zhang
BACKGROUND: Guillain-Barré syndrome (GBS) was a severe peripheral nervous disease that leading to muscle weakness and areflexia. We now commonly accept a synthesis that inflammation and immunity play a key role in GBS pathogenesis. Many studies pointed out that neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) are novel promising markers of inflammation or immunity. Our study aimed to evaluate whether the NLR and the MLR were associated to GBS or not. PATIENTS AND METHODS: We measured blood cell count in 334 individuals, including 117 GBS and 217 healthy controls...
December 18, 2017: International Journal of Neuroscience
Ying-Ying Li, Bei Zhang, Ke-Wei Yu, Ce Li, Hong-Yu Xie, Wei-Qi Bao, Yan-Yan Kong, Fang-Yang Jiao, Yi-Hui Guan, Yu-Long Bai
PURPOSE: Constraint-induced movement therapy (CIMT) can improve motor functions in stroke patients and ischemic rats. This study examined the effect of CIMT in ischemic rats using positron emission tomography (PET). METHODS: We used middle cerebral artery occlusion (MCAO) procedure to induce cerebral ischemia in rats. Male rats were divided into a negative control group (Normal, n = 4), a sham-operated group (Sham, n = 6), an ischemic group (Control, n = 6), and an ischemic CIMT-treated group (CIMT, n = 6)...
December 18, 2017: International Journal of Neuroscience
Francesc Valldeoriola, Antonio Salvador, José Maria Gómez-Arguelles, José Marey, Miguel Moya, Ángel Ayuga, Francisco Ramírez
AIM: This study evaluated the effect of ≥6 months of transdermal rotigotine on non-motor and motor symptoms of patients with advanced Parkinson's disease. MATERIALS AND METHODS: The study was conducted in Spain between September 2011 and December 2012 ( NCT01504529). The primary efficacy variable was the change from baseline in non-motor symptoms, as assessed by changes in Parkinson's Disease Non-Motor Symptoms Questionnaire total scores at 6 months...
December 17, 2017: International Journal of Neuroscience
Mehmet Dumlu Aydın, Nazan Aydın, Ayhan Kanat, Nezih Akca, Gizem Ardic, Coskun Yolas, Konca Altınkaynak, Muhammet Calik
AIM: The morphologic mechanism of orgasmic sensation has not yet been understood. Taste roseas may be stimulated by fructose via pudendal nerves, which has not been studied yet. METHODS: In this study, 27 male adult rabbits were used, which were divided into three groups: 5 as control; 5 as SHAM and 17 used as study group. We injected 0.2 cc of distilled water to SHAM and 0.2 cc of fructose solution to the study group of their urethral orifices, and examined the occurrence of penile erection...
December 17, 2017: International Journal of Neuroscience
Nian-Ge Xia, Yan-Yan Chen, Jia Li, Xi Chen, Zu-Sen Ye, Si-Yan Chen, Zhen-Guo Zhu
BACKGROUND: Eight-and-a-half syndrome is caused by a lesion in the dorsal tegmentum of the caudal pons involving parapontine reticular formation (PPRF) and the median longitudinal fasciculus (MLF), as well as the nucleus and/or the fasciculus of the facial nerve. It is characterized by one-and-a-half syndrome and an ipsilateral cranial nerve VII palsy. There are also many variants of eight-and-a-half syndrome has been described, including nine syndrome, thirteen-and-a-half syndrome, and fifteen-and-a-half syndrome...
December 15, 2017: International Journal of Neuroscience
Junzhao Cui, Hui Bu, Junying He, Zeyan Zhao, Weixin Han, Ruiping Gao, Xiaoqing Li, Qing Li, Xiaosu Guo, Yueli Zou
PURPOSE: We report 11 patients diagnosed with GABAB receptor (GABABR) antibodies encephalitis in China and aim to analyze the clinical characteristics, laboratory and imaging findings, therapeutic modalities and outcomes. METHODS: Clinical data from patients diagnosed with anti-GABAB receptor encephalitis in the Second Affiliated Hospital of Hebei Medical University from February 2016 to October 2016 January were retrospectively collected and evaluated. RESULTS: Of the 11 patients, seven were males, and a mean age at presentation of 63 years (range: 47-79 years)...
December 6, 2017: International Journal of Neuroscience
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