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International Journal of Neuroscience

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https://www.readbyqxmd.com/read/27875923/age-of-onset-of-mesial-temporal-lobe-epilepsy-with-hippocampal-sclerosis-the-effect-of-apolipoprotein-e-and-febrile-seizures
#1
Bárbara Leal, João Chaves, Cláudia Carvalho, Andreia Bettencourt, Joel Freitas, João Lopes, João Ramalheira, Paulo P Costa, Denisa Mendonça, António M Silva, Berta M Silva
PURPOSE: Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (MTLE-HS) is the most frequent pharmaco-resistant epilepsy. It has been associated with febrile seizures (FS) in childhood. Its aetiology remains unclear but genetic factors are involved. Apolipoprotein E (ApoE) is the main lipoprotein secreted in brain. It has a critical immunomodulatory function, influences neurotransmission and it is involved in repairing damaged neurons. ApoEϵ4 is an isoform of ApoE with altered protein function, previously associated with refractoriness and early onset epilepsy...
November 22, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27871212/contributions-of-triggering-receptor-expressed-on-myeloid-cells-2-to-neurological-diseases
#2
Jie Han, Miaomiao Wang, Manru Ren, Haiyan Lou
Recent laboratory and gene sequencing data suggest that variations in receptors called the "triggering-receptors-expressed-on-myeloid-cells" (TREMs), are implicated in Alzheimer's disease, Parkinson's disease, multiple sclerosis, and frontotemporal lobar degeneration. TREM receptors are thought to play a critical role in regulating the immune system, inflammation, and certain cellular functions. One TREM in particular, TREM2, is highly expressed on cells of the myeloid lineage. The binding of TREM2 to the adapter protein, DNAX activating protein of 12 kD (DAP12), in microglial cells has been shown to modulate phagocytosis within the nervous system...
November 22, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27798970/second-mutation-in-park2-is-absent-in-patients-with-sporadic-parkinson-s-disease-and-heterozygous-exonic-deletions-duplications-in-parkin-gene
#3
Marina V Shulskaya, Maria I Shadrina, Ekaterina Yu Fedotova, Nataliya Yu Abramycheva, Svetlana A Limborska, Sergey N Illarioshkin, Petr A Slominsky
AIM OF THE STUDY: Mutations in PARK2 are one of the causes of Parkinson's disease (PD). Deletions and duplications/triplications of one exon or exon groups account for a large proportion of mutations in the gene. At the present time, it is still not fully clear whether heterozygous mutations cause the development of PD. Our study aimed at conducting screening for mutations in PARK2 in patients with a sporadic form of PD to clarify the role of PARK2 in the development of PD. MATERIALS AND METHODS: The cohort of 327 patients with PD was screened by quantitative real-time polimerase chain reaction (PCR) with subsequent Sanger sequencing...
November 16, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27842450/the-central-cannabinoid-receptor-type-2-cb2-and-chronic-pain
#4
Yuchao Shang, Yuying Tang
Cannabinoid receptor type-2 (CB2, CB2 Receptor, or CB2-R) mediates analgesia, via two mechanisms. CB2 receptors contained in peripheral immune tissue mediates analgesia by altering cytokine profiles, and thus has little adverse effects on central nervous systems. CB2 is also expressed in the neurons and glial cells of the Central Nervous System (CNS). This neuronal expression may also contribute to pain attenuation. The CB2 receptor has been proposed as a potential target in treating chronic pain of several etiologies...
November 15, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27838939/aquaporin-4-antibody-in-neuromyelitis-optica-re-testing-study-in-a-large-population-from-china
#5
Youming Long, Junyan Liang, Rong Zhong, Linzhan Wu, Wei Qiu, Shaopeng Lin, Cong Gao, Xiaohui Chen, Xueping Zheng, Ning Yang, Min Gao, Zhanghang Wang
BACKGROUND: Aquaporin-4 (AQP4) antibody seropositivity is critically important in neuromyelitis optica (NMO). However, the sensitivity of different assays is highly variable. Repeating detection with a highly sensitive assay in a large population is necessary in the case of so-called negative NMO. METHODS: Retrospective analysis where AQP4 antibodies were detected by commercial cell-based assay(CBA), in-house M23-CBA, and in-house M1-CBA. RESULTS: Of the 1011 serum samples, 206 (20...
November 14, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27838946/cerebral-small-vessel-disease-and-post-stroke-cognitive-impairment
#6
Zhenjie Teng, Yanhong Dong, Dandan Zhang, Jin An, Peiyuan Lv
Cerebral small vessel disease (CSVD) refers to a group of pathological processes with multifarious aetiologies that affect the small arteries, arterioles, venules, and capillaries of the brain. Features seen on neuroimaging include white matter hyperintensities, lacunar infarction, cerebral microbleeds, brain atrophy, microinfarcts and enlarged perivascular spaces (EPVS). CSVD gives rise to one in five strokes worldwide and is a leading cause of cognitive impairment and dementia, especially in the elderly. Post-stroke cognitive impairment (PSCI) is one of the most common subtypes of cognitive impairment...
November 13, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27819773/prognosis-of-thymectomy-in-myasthenia-gravis-patients-with-thymus-hyperplasia
#7
Jing Yang, Chanchan Liu, Tao Li, Chengyan Li
PURPOSE: To compare the post-thymectomy prognosis in different conditions of myasthenia gravis (MG) patients with thymus hyperplasia. MATERIALS AND METHODS: Collecting medical record and carrying out the follow-up study of one hundred and twenty three myasthenia gravis patients with thymus hyperplasia who have underwent thymectomy during the period between 2003 and 2013. Dividing into different groups based on gender, age of onset, duration of disease and Myasthenia Gravis Association of America (MGFA) clinical classification to analyze different prognosis in different groups...
November 7, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27819760/reversible-cerebral-vasoconstriction-syndrome-in-association-with-fingolimod-use
#8
Scott Belliston, Jayshree Sundararajan, Kathy Newell, Sharon Lynch
BACKGROUND: Reversible cerebral vasoconstriction syndrome (RCVS), also known as Call-Fleming syndrome, is characterized by thunderclap headaches, non-aneurysmal segmental cerebral vasoconstriction seen on arteriogram, and spontaneously resolves within twelve weeks. Fingolimod has been reported to cause posterior reversible encephalopathy syndrome (PRES) and one case of RCVS. OBJECTIVE: We report a case of RCVS possibly related to fingolimod use, and compare to cases of adverse outcomes in fingolimod use...
November 7, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27819176/determination-of-cd-cr-pb-and-ni-contents-among-parkinson-s-disease-individuals-a-case-control-study
#9
Vineeta Gupta, Nasreen Ghazi Ansari, Ravindra Kumar Garg, Sanjay Khattri
BACKGROUND: Various uses of metals in industries, including the domestic sphere, agriculture, medicine and technology, have led to their wide distribution in the environment. These result in raising concerns over their potential effects on human health and the environment. Because of their high degree of toxicity, Cd, Cr and Pb are some of the priority metals that are of public health significance. The levels of Cd, Cr, Pb and Ni were measured in Parkinson's disease (PD) patients. METHODS: Blood samples were collected from 40 patients and 40 healthy controls, and stored at -80 °C until assayed...
November 6, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27788616/distinctive-characteristics-of-early-onset-and-late-onset-neuromyelitis-optica-spectrum-disorders
#10
Lin-Jie Zhang, Li-Na Yang, Ting Li, Jing Wang, Yuan Qi, Da-Qi Zhang, Chun-Sheng Yang, Li Yang
OBJECTIVES: Little is known about patients with neuromyelitis optica spectrum disorders (NMOSD) as defined by onset age. This study aimed to analyze the different demographic, clinical, laboratory, and magnetic resonance imaging (MRI) characteristics in early-onset (≤ 50 years) NMOSD (EONMOSD) and late-onset (> 50 years) NMOSD (LONMOSD). MATERIALS AND METHODS: We enrolled 142 patients with NMOSD from Tianjin Medical University General Hospital, Tianjin, China, and categorized them into two groups according to the age of onset: EONMOSD and LONMOSD...
October 27, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27788613/susac-s-syndrome-clinical-course-and-epidemiology-in-a-central-european-population
#11
Thomas Seifert-Held, Beate J Langner-Wegscheider, Martina Komposch, Philipp Simschitz, Claudia Franta, Barbara Teuchner, Hans Offenbacher, Ferdinand Otto, Johann Sellner, Helmut Rauschka, Franz Fazekas
OBJECTIVE: Susac's syndrome is characterized by inflammation and occlusion of pre-capillary arterioles with the clinical triad of branch retinal artery occlusion (BRAO), encephalopathy and hearing loss. No epidemiological data is available for the disease. METHODS: All neurology departments in Austria were addressed to report adult patients who were on immunosuppressive treatment for a diagnosis of Susac's syndrome between 1(st) August 2010 and 1(st) August 2015...
October 27, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27780382/corrigendum
#12
(no author information available yet)
No abstract text is available yet for this article.
October 26, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27766907/determination-of-cd-cr-pb-and-ni-contents-among-parkinson-s-disease-individuals-a-case-control-study
#13
Vineeta Gupta, Nasreen Ghazi Ansari, Ravindra Kumar Garg, Sanjay Khattri
BACKGROUND: Various uses of metals in industries, including the domestic sphere, agriculture, medicine, and technology, have led to their wide distribution in the environment. These result in raising concerns over their potential effects on human health and the environment. Because of their high degree of toxicity, Cd, Cr, and Pb are some of the priority metals that are of public health significance. The levels of Cd, Cr, Pb, and Ni were measured in Parkinson's disease patients. METHODS: Blood samples were collected from 40 patients and 40 healthy controls, and stored at -80 °C until assayed...
October 21, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27740882/effects-of-coordination-and-manipulation-therapy-for-patients-with-parkinson-disease
#14
Mingming Zhao, Caiyou Hu, Zhixin Wu, Yu Chen, Zhengming Li, Mingsheng Zhang
PURPOSE: To determine the effects of a new exercise training regimen, i.e. coordination and manipulation therapy (CMT), on motor, balance, and cardiac functions in patients with Parkinson disease (PD). MATERIALS AND METHODS: We divided 36 PD patients into the CMT (n = 22) and control (n = 14) groups. The patients in the CMT group performed dry-land swimming (imitation of the breaststroke) and paraspinal muscle stretching for 30 min/workday for 1 year. The control subjects did not exercise regularly...
November 11, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27680606/monoclonal-antibody-therapy-for-neuromyelitis-optica-spectrum-disorder-current-and-future
#15
Jie Lin, Binbin Xue, Xiang Li, Junhui Xia
Monoclonal-antibody has been used for patients with autoimmune disorders for several years, and efficacy and safety were appreciated for these patients. Neuromyelitis optica specturm disorder (NMOSD) has been defined as an autoimmune demyelination disorder of the central nervous system (CNS) with a course of relapse-remission. Treatment of prevention is important for patients with NMOSD because of the increased disability after several attacks. Multiple factors were involved in the pathogenesis of NMOSD. Currently, targeting specific factor was favored in the research into the treatment for NMOSD...
October 14, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27671515/processes-of-plasma-protein-n-homocysteinylation-in-multiple-sclerosis
#16
A Jamroz-Wiśniewska, J Bełtowski, H Bartosik-Psujek, G Wójcicka, K Rejdak
BACKGROUND: Homocysteine thiolactone (HTL) is a cyclic thioester of homocysteine (Hcy) contributing to the toxicity of this amino acid. HTL spontaneously reacts with protein lysine residues leading to altered properties of target proteins and induction of immune response. HTL is hydrolyzed to Hcy by plasma enzyme, paraoxonase 1 (PON1). Although both Hcy and PON1 may be involved in the pathogenesis of multiple sclerosis (MS), protein modification by HTL in this disease has not been studied so far...
October 14, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27734716/a-review-of-the-role-of-synaptosomal-associated-protein-25-snap-25-in-neurological-disorders
#17
Aneeqa Noor, Saadia Zahid
Synaptosomal-associated protein 25 kDa (SNAP-25) is one of the key proteins involved in formation of neural soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes, which are responsible for the calcium-dependent exocytosis of neurotransmitters - a major step in neurotransmission and the key to normal functioning of brain. Several studies have reported abnormalities in its expression and structure and highlighted it as an important player in pathology of various neurological disorders like Alzheimer's disease, schizophrenia, attention deficient hyperactivity disorder, epilepsy and few others...
October 13, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27647380/association-of-parkinson-s-disease-with-hospitalization-for-traumatic-brain-injury
#18
Kavelin Rumalla, Keerthi T Gondi, Adithi Y Reddy, Manoj K Mittal
PURPOSE: The goal of our study was to determine if patients with Parkinson's disease (PD) are more susceptible to hospitalization for traumatic brain injury (TBI). METHODS: The US Nationwide Inpatient Sample database was queried (2004-2011) to identify cohorts of patients with PD (N = 1 047 656) and without PD (N = 115 95 173). The age range of the study population was 60-89 years. The incidence of TBI among patients with PD was compared to the incidence of TBI in patients without PD...
October 13, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27718773/difference-of-hospital-charges-for-stroke-inpatients-between-hospitals-with-different-levels-and-therapeutic-modes-in-beijing-china
#19
Xiaochuan Huo, Bin Jiang, Zhenghong Chen, Xiaojuan Ru, Haixin Sun, Dongling Sun, Di Li, Wenzhi Wang
OBJECTIVES: The present study analyzed the hospital charges for stroke patients in China and determined the factors associated with hospital costs. METHODS: Medical records of hospitalized patients with a primary diagnosis of acute stroke were collected from 121 hospitals in Beijing (2012). Distribution characteristics of hospital charges for different stroke types, hospital levels and types were studied. Factors influencing total hospital charges were analyzed...
October 8, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27619486/a-novel-tyrosine-hydroxylase-variant-in-a-group-of-chinese-patients-with-dopa-responsive-dystonia
#20
Ya-Ping Yan, Bo Zhang, Yan-Fang Mao, Zhang-Yu Guo, Jun Tian, Guo-Hua Zhao, Jia-Li Pu, Wei Luo, Zhi-Yuan Ouyang, Bao-Rong Zhang
Dopa-responsive dystonia (DRD) comprises a heterogeneous group of movement disorders. A limited number of studies of Chinese patients with DRD have been reported. In the present study, we investigated the clinical and genetic features of 12 Chinese DRD families. Point mutation analysis of the GTP-cyclohydrolase I (GCH1), tyrosine hydroxylase (TH) and sepiapterin reductase (SPR) genes was conducted by direct sequencing. In addition, multiplex ligation-dependent probe amplification targeting GCH1 and TH was performed in "mutation-free" patients...
October 5, 2016: International Journal of Neuroscience
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