We have located links that may give you full text access.
Extra-prostatic extension (EPE) grading system: Correlation with MRI features and integration of capsular enhancement sign (CES) for "enhanced" detection of T3a lesions.
British Journal of Radiology 2024 March 28
PURPOSE: This study aims to confirm the diagnostic accuracy of extra-prostatic extension (EPE) grading system and to explore the predictive capabilities of the prostate MRI while considering various MRI features such as lesion location, ADC values and capsular enhancement sign (CES).
MATERIALS AND METHODS: Our monocentric study is based on a retrospective analysis of 99 patients who underwent radical prostatectomy from January 2021 to January 2023. The observers reviewed for each lesion, including location (transitional or peripheral zone, anterior or posterior location), capsular contact length, irregular bulging of the capsule, asymmetry of the neuro-vascular bundle, obliteration of the recto-prostatic angle, macroscopic EPE, ADC value, and CES.
RESULTS: Among 99 patients, 31 patients had EPE. Lesions with EPE have broadercapsule contact (24 mm vs 12 mm) with contact ≥14mm being the optimal cut-off for EPE discrimination.Among the morphological MRI criteria used to determine the EPE, the one with major sensitivity was shown to be bulging (sen 81%), while macroscopic extension had highest specificity (100%).Univariate analysis showed as significative risk factors for EPE: capsular contact ≥14 mm (p < 0.001), ISUP ≥3 (p 0.005), CES (p < 0.001), bulging (p 0.001), neuro-vascular bundle asymmetry (p < 0.001) and EPE score ≥2 (p < 0.001), and in multivariate analysis CES (p 0.001) and EPE score ≥2 (p 0.004) were significant.The AUC of the EPE score was 0.76, raised to 0.83 when combining it with CES (P = 0.11).
CONCLUSION: CES in the setting of multiparametric MRI can increase diagnostic accuracy for the prediction of extra-capsular disease.
ADVANCES IN KNOWLEDGE: This study highlights the potential of contrast media in prostate cancer local staging.
MATERIALS AND METHODS: Our monocentric study is based on a retrospective analysis of 99 patients who underwent radical prostatectomy from January 2021 to January 2023. The observers reviewed for each lesion, including location (transitional or peripheral zone, anterior or posterior location), capsular contact length, irregular bulging of the capsule, asymmetry of the neuro-vascular bundle, obliteration of the recto-prostatic angle, macroscopic EPE, ADC value, and CES.
RESULTS: Among 99 patients, 31 patients had EPE. Lesions with EPE have broadercapsule contact (24 mm vs 12 mm) with contact ≥14mm being the optimal cut-off for EPE discrimination.Among the morphological MRI criteria used to determine the EPE, the one with major sensitivity was shown to be bulging (sen 81%), while macroscopic extension had highest specificity (100%).Univariate analysis showed as significative risk factors for EPE: capsular contact ≥14 mm (p < 0.001), ISUP ≥3 (p 0.005), CES (p < 0.001), bulging (p 0.001), neuro-vascular bundle asymmetry (p < 0.001) and EPE score ≥2 (p < 0.001), and in multivariate analysis CES (p 0.001) and EPE score ≥2 (p 0.004) were significant.The AUC of the EPE score was 0.76, raised to 0.83 when combining it with CES (P = 0.11).
CONCLUSION: CES in the setting of multiparametric MRI can increase diagnostic accuracy for the prediction of extra-capsular disease.
ADVANCES IN KNOWLEDGE: This study highlights the potential of contrast media in prostate cancer local staging.
Full text links
Related Resources
Trending Papers
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
British Society for Rheumatology guideline on management of adult and juvenile onset Sjögren disease.Rheumatology 2024 April 17
Albumin: a comprehensive review and practical guideline for clinical use.European Journal of Clinical Pharmacology 2024 April 13
Renin-Angiotensin-Aldosterone System: From History to Practice of a Secular Topic.International Journal of Molecular Sciences 2024 April 5
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app